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Preoperative Axillary Ultrasound-guided Wire Localization and Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Breast Cancer Patients 乳腺癌前哨淋巴结活检术前腋窝超声引导钢丝定位及淋巴显像
Pub Date : 2021-12-11 DOI: 10.18502/bccr.v12i4.7982
Fezzeh Elyasinia, Homa Hemmasi, K. Toolabi, A. Alikhassi, Mehran Sohrabi Maralani, E. Sadeghian
Background: Breast cancer has the highest incidence and mortality among female malignant tumors. Breast cancer with negative axillary lymph nodes has been diag- nosed mainly at an early stage. Sentinel lymph node biopsy (SLNB) is a standard screening technique for patients with early-stage breast cancer and clinically nega- tive lymph nodes. Lymphoscintigraphy (sentinel lymph node mapping) has been reg- ularly used as the standard method for SLNB. Today, ultrasound-guided wire locali- zation (USGWL) is a well-established technique with superior outcomes. Therefore, we attempted to determine whether preoperative UGWL and lymphoscintigraphy (blue dye and isotope injection) improve SLN detection and false-negative rate in breast cancer patients undergoing SLNB and identify clinical factors that may affect the diagnostic accuracy of axillary ultrasound (AUS). Methods: Between December 2018 and June 2019, 55 patients with clinical T1- 3N0 breast cancer eligible for an SLNB at Imam Khomeini Hospital in Tehran were included in our study. Tumor characteristics and demographic data were collect- ed by reviewing medical records and questionnaires prepared by our surgical team. The day before SLNB, all patients underwent ultrasound-guided wire localization of SLN. Lymphoscintigraphy was performed with an unfiltered 99mTc-labelled sulfur colloid peritumoral injection followed by methylene blue dye injection. The results were analyzed based on the permanent pathology report. Results: Among the 55 patients, 71.8% of SLNs were detected by wire localization, while 57.8% were found by methylene blue mapping and 59.6% by gamma probe detection. Compared with wire localization and isotope injection, the methylene blue dye technique had a low sensitivity (72.2%), while both wire localization and isotope injection reached 77.8%. The sensitivity, specificity, and accuracy of UGWL were 77.8%, 42.1%, and 65.4%, respectively. Otherwise, methylene blue dye and isotope injection accuracy was 47.3% and 50.1%, respectively. Furthermore, there was a significant relationship between BMI, tumor size, laterality, reactive ALN, and the accuracy of preoperative AUS. But there was no significant correlation between age, weight, height, tumor biopsy, tumor location, the time interval between methylene blue dye and isotope injection to surgery, and also the type of surgery to the accuracy of preoperative AUS. Conclusion: Preoperative UGWL can effectively identify SLNs compared to lym- phoscintigraphy (blue dye and isotope injection) in early breast cancer patients un- dergoing SLNB.
背景:乳腺癌是女性恶性肿瘤中发病率和死亡率最高的肿瘤。腋窝淋巴结阴性的乳腺癌主要在早期诊断。前哨淋巴结活检(SLNB)是早期乳腺癌和临床阴性淋巴结患者的标准筛查技术。淋巴显像(前哨淋巴结作图)已被经常用作SLNB的标准方法。目前,超声引导钢丝定位(USGWL)是一种成熟的技术,具有良好的效果。因此,我们试图确定术前UGWL和淋巴显像(蓝色染料和同位素注射)是否能提高乳腺癌SLNB患者SLN的检出率和假阴性率,并确定可能影响腋下超声(AUS)诊断准确性的临床因素。方法:2018年12月至2019年6月,在德黑兰伊玛目霍梅尼医院(Imam Khomeini Hospital)接受SLNB治疗的55例临床T1- 3N0乳腺癌患者纳入我们的研究。肿瘤特征和人口统计数据是通过回顾病历和外科小组准备的问卷收集的。在SLNB的前一天,所有患者都接受了超声引导下的SLN定位。淋巴显像采用未经过滤的99mtc标记的硫胶体瘤周注射,然后注射亚甲基蓝染料。根据永久性病理报告对结果进行分析。结果:55例患者中,钢丝定位检出率为71.8%,亚甲蓝定位检出率为57.8%,伽玛探针检测检出率为59.6%。与线定位和同位素注入技术相比,亚甲基蓝染料技术的灵敏度较低(72.2%),而线定位和同位素注入技术的灵敏度均为77.8%。UGWL的敏感性为77.8%,特异性为42.1%,准确性为65.4%。亚甲基蓝染料和同位素注射精度分别为47.3%和50.1%。此外,BMI、肿瘤大小、侧边性、反应性ALN与术前AUS的准确性之间存在显著关系。但年龄、体重、身高、肿瘤活检、肿瘤位置、亚甲蓝染色与同位素注射时间间隔、手术类型与术前AUS准确性无显著相关性。结论:与lym-光照术(蓝色染料和同位素注射)相比,术前UGWL能有效识别早期乳腺癌SLNB患者的sln。
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引用次数: 0
A Study on the Relationship Between Tumor Size, Tumor Grade and Lymph Node Involvement in Canine Mammary Cancer: Simulation of Tumor Behavior in Human Breast Cancer 犬乳腺癌肿瘤大小、肿瘤分级与淋巴结累及关系的研究:人类乳腺癌肿瘤行为的模拟
Pub Date : 2021-12-11 DOI: 10.18502/bccr.v12i4.7983
Sanaz Rismanchi, P. Mortazavi, S. Muhammadnejad
Background: In the last two decades, canine mammary cancer has played an essential role in human breast cancer research. There are various similarities between biological and clinical features of canine breast cancer and female breast cancer in many cases. Clinical studies and evaluation of prognostic factors in canine mammary cancer can increase reliability in generalizing results to human cancers. This study was performed in the direction of comparative oncology. Methods: We collected clinicopathological data of an invasive type of canine mammary carcinoma from clinical records and pathology reports. Age, tumor laterality, tumor size, lymph node status, and tumor grade were recorded, and the relationships between the parameters were evaluated using linear regression analysis. Results: Ninety-seven patients were included in the study, and the mean age was 10.06 ± 2.73 years. The left mammary gland was involved in 51% of cases, and pT2 was the most common tumor size. Lymph nodes were involved in 27% of patients, and 43% of tumors were grade I. Statistical analysis showed no relationship between tumor size and laterality with other clinicopathological features. However, there was a statistically significant relationship between tumor size and tumor grade, and lymph node status. As the tumor size increased, tumor grade and the risk of lymph node involvement raised. Conclusion: Similar results of this study to breast cancer in women show that canine mammary carcinoma is a suitable model in comparative oncology research. Dogs live shorter than humans so that researchers can get the results of treatment and perform survival rate assessments faster in clinical trials. By considering ethical principles, dogs with breast cancer may replace phases I and II of human clinical trials in some cancer types soon.
背景:在过去的二十年中,犬乳腺癌在人类乳腺癌研究中发挥了重要作用。犬乳腺癌的生物学和临床特征在许多情况下与女性乳腺癌有许多相似之处。犬乳腺癌预后因素的临床研究和评估可以提高将结果推广到人类癌症的可靠性。本研究的方向是比较肿瘤学。方法:我们从临床记录和病理报告中收集了一例浸润型犬乳腺癌的临床病理资料。记录年龄、肿瘤侧边、肿瘤大小、淋巴结状态和肿瘤分级,并利用线性回归分析评估参数之间的关系。结果:纳入97例患者,平均年龄10.06±2.73岁。51%的病例累及左乳腺,pT2是最常见的肿瘤大小。27%的患者有淋巴结累及,43%的肿瘤为i级。统计学分析显示肿瘤的大小和侧边性与其他临床病理特征没有关系。然而,肿瘤大小、肿瘤分级和淋巴结状态之间有统计学意义的关系。随着肿瘤大小的增加,肿瘤分级和累及淋巴结的风险也随之增加。结论:本研究结果与女性乳腺癌相似,表明犬乳腺癌是比较肿瘤学研究的合适模型。狗的寿命比人类短,因此研究人员可以在临床试验中更快地获得治疗结果并进行存活率评估。考虑到伦理原则,患有乳腺癌的狗可能很快就会取代某些癌症类型的人类临床试验的第一和第二阶段。
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引用次数: 0
Prognostic Role of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in the Survival of Patients with Esophageal Cancer 中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值在食管癌患者生存中的预后作用
Pub Date : 2021-12-11 DOI: 10.18502/bccr.v12i4.7981
M. Tajik, Mohammad Shirkhoda, Maryam Hadji, Monireh Sadat Seyyed- salehi, E. Saeidi, K. Zendehdel
Background: Different factors can affect the future of a person with cancer. The patient’s systemic inflammatory response is an important factor. Several inflammatory markers have been evaluated for measuring the patient’s response to cancer. We evaluated neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as prognostic factors for survival in patients with pathologically proven esophageal cancer. Methods: In this retrospective cohort study, patients with pathologically approved esophageal cancer, who underwent surgical treatment in the cancer institute of Iran, were included. Demographic, pathological, and laboratory data of patients were obtained from the archive of medical records. Results: In this study, 135 patients with esophageal cancer with a mean age of 60 were studied. The median time of the follow-up period was 21 months. Mean NLR and PLR were 7.05 and 898, respectively. Patients’ survival had a significant relationship with their age, gender, tumor differentiation, receiving chemotherapy, absolute neutrophil count, total bilirubin, direct bilirubin, and NLR. Conclusion: According to the results, in a multivariable investigation, it was demonstrated that a high NLR has a direct effect on patients’ poor survival.
背景:不同的因素会影响癌症患者的未来。患者的全身炎症反应是一个重要因素。已经评估了几种炎症标记物来衡量患者对癌症的反应。我们评估了中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)作为病理证实的食管癌患者生存的预后因素。方法:在这项回顾性队列研究中,纳入了在伊朗癌症研究所接受手术治疗的病理批准的食管癌患者。患者的人口统计、病理和实验室数据均来自医疗档案。结果:本研究纳入135例食管癌患者,平均年龄60岁。中位随访时间为21个月。平均NLR和PLR分别为7.05和898。患者的生存与年龄、性别、肿瘤分化程度、是否接受化疗、中性粒细胞绝对计数、总胆红素、直接胆红素、NLR有显著关系。结论:根据结果,在一项多变量调查中,高NLR直接影响患者的不良生存。
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引用次数: 0
The Role of Cancer Charities in Breast Cancer Prevention in Iran 癌症慈善机构在伊朗预防乳腺癌中的作用
Pub Date : 2021-12-11 DOI: 10.18502/bccr.v12i4.7984
A. Nahvijou, M. Mohagheghi, Massoumeh Guiti, Afssoun Mahouri, Nafisseh Fathnia Tabari, Fatemeh Raesspour, Roghayeh Abedi, Azin Rabiean, F. Khaleghi, Leili Rezaei, Rana Barazandeh, M. mousavinezhad, Ali Akbar Khazen, Parisa Ahmadian, K. Zendehdel
Background: Cancer is a significant public health problem, and its burden is increasing globally, especially in low- and middle-income countries. Cancer charities, alongside the government, could address health issues based on their goals. We studied the activities of cancer charities related to breast cancer (BC) prevention in Iran. Methods: We designed a situational analysis study. We abstracted the cancer charities’ objectives that were members of the “Iran Cancer National Network of NGOs and Charities (IRCNNC).” We also searched for their international activities. We reviewed the BC prevention programs conducted by Iranian cancer charities and collected their data and information regarding BC awareness and screening. Results: Overall, 43 charities were an active member of the IRCNNC and were engaged in 6 areas, including 1) financial and non-financial supports, 2) providing medical services, 3) providing accommodation to companions of the patients traveling from other cities, 4) supplying infrastructure and medical equipment to cancer hospitals, 5) conducting scientific and research activities, and 6) running educational and awareness campaigns. Most actions were on financial and non-financial supports. Seven charities are a member of the Union for International Cancer Control (UICC). Five charities reported their movement on BC prevention. Conclusion: Most charities did not document their prevention programs and did not follow an organized screening program. Training and capacity building is needed to support the cancer charities for the evidence-based cancer prevention program.
背景:癌症是一个重大的公共卫生问题,其负担正在全球范围内增加,特别是在低收入和中等收入国家。癌症慈善机构和政府可以根据自己的目标来解决健康问题。我们研究了伊朗与乳腺癌(BC)预防有关的癌症慈善活动。方法:设计情境分析研究。我们将“伊朗癌症非政府组织和慈善机构全国网络(IRCNNC)”的成员作为癌症慈善机构的目标进行了抽象。我们还搜索了他们的国际活动。我们审查了伊朗癌症慈善机构开展的BC预防项目,并收集了他们关于BC意识和筛查的数据和信息。结果:总体而言,43家慈善机构是IRCNNC的活跃成员,从事6个领域,包括1)财政和非财政支持,2)提供医疗服务,3)为来自其他城市的患者的同伴提供住宿,4)为癌症医院提供基础设施和医疗设备,5)开展科学研究活动,6)开展教育和宣传活动。大多数行动涉及财政和非财政支助。七个慈善机构是国际癌症控制联盟(UICC)的成员。五个慈善机构报告了他们在预防BC方面的行动。结论:大多数慈善机构没有记录他们的预防项目,也没有遵循有组织的筛查项目。需要培训和能力建设来支持癌症慈善机构以证据为基础的癌症预防项目。
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引用次数: 2
Limitation of Experimental Research on Opium Consumption and Cancer Development in Human: Call for Establishment of an International Consortium 鸦片消费与人类癌症发展实验研究的局限性:建立国际联盟的呼吁
Pub Date : 2021-03-16 DOI: 10.18502/BCCR.V12I3.5772
K. Zendehdel
The article's abstract is not available.
这篇文章的摘要没有。
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引用次数: 0
Giant Cell Variant of Glioblastoma Multiforme: Report of a Rare Variant in a Child 多形性胶质母细胞瘤巨细胞变异:一罕见儿童变异报告
Pub Date : 2021-03-16 DOI: 10.18502/BCCR.V12I3.5771
Zahra Aminparast, M. Ramezani
Malignant glial tumors are rare in children. Giant cell variant is a rare subtype of glioblastoma, accounting for about 0.8% of brain tumors and 5% of glioblastoma tumors. Giant cell glioblastoma is a male predominant tumor in children and adults. Due to the low prevalence of this variant, available information is limited. An 11-year-old female child was referred with a chief complaint of a progressive persistent headache. MRI showed a well-defined cystic lesion with a solid mural component in the right parietal lobe with a compression effect on the ipsilateral ventricular system. Surgery was done. After the pathologist reported glioblastoma multiforme, a giant cell variant, the patient received 30 sessions of radiation therapy. The patient was readmitted 18 months later with a headache, and the pathologist confirmed the recurrence of the tumor. Based on radiology, the giant cell glioblastoma cannot be distinguished from the common subtype glioblastoma. The pathologists must be aware of this entity, and histologic differential diagnoses are warranted for diagnostic, prognostic, and therapeutic purposes.
恶性神经胶质肿瘤在儿童中很少见。巨细胞变异是一种罕见的胶质母细胞瘤亚型,约占脑肿瘤的0.8%,占胶质母细胞瘤的5%。巨细胞胶质母细胞瘤是一种主要发生于儿童和成人的男性肿瘤。由于这种变异的流行率很低,可用的信息有限。一名11岁女童,主诉为进行性持续性头痛。MRI显示右顶叶有明确的囊性病变,伴实性壁壁成分,对同侧心室系统有压迫作用。手术完成了。在病理学家报告多形性胶质母细胞瘤(一种巨细胞变体)后,患者接受了30次放射治疗。患者18个月后因头痛再次入院,病理证实肿瘤复发。基于放射学,巨细胞胶质母细胞瘤不能与普通亚型胶质母细胞瘤区分开来。病理学家必须意识到这个实体,组织学鉴别诊断是诊断、预后和治疗目的的保证。
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引用次数: 0
The Effects of Individual Diet Therapy on Food Intake, Quality of Life, and Related Serum Proteins in Patients with Breast Cancer: A Randomized Clinical Trial 个体化饮食治疗对乳腺癌患者食物摄入、生活质量和相关血清蛋白的影响:一项随机临床试验
Pub Date : 2021-03-16 DOI: 10.18502/BCCR.V12I3.5768
A. Fallah, Kiana Parnian, H. Abdolazimi, Sajjad Tezerji, Z. Mazloom
Background: In cancer patients, weight loss due to malnutrition has a significant impact on the patients’ treatment and quality of life. This study aimed to determine the appropriate therapeutic strategy to control the side effects of chemotherapy in patients with breast cancer to improve their health, quality of life, and nutritional status. Methods: In our prospective study, we examined gastric cancer patients who were Seventy patients undergoing chemotherapy were included and randomly divided into intervention (n=35) and control groups (n=35). The intervention group received an individualized diet according to their nutritional needs for eight weeks, and the control group received dietary advice on the side effects of chemotherapy. Malnutrition, nutritional barriers, and patients’ quality of life were evaluated by PG-SGA, nutritional barriers, and QLQ-C30 questionnaires. Serum proteins were also assessed at the beginning and the end of the study. Results: The patients’ mean age was 50.91±1.72 years in the intervention group and 51±1.35 in the control group. According to the PG-SGA questionnaire classification, 68.5% of patients had malnutrition at baseline. In the intervention group, the mean score of PG-SGA decreased, which indicated an improvement in patients’ nutritional status. Increased scores in the functional section of QLQC30 and a decrease in the symptom section of this questionnaire indicated the improved quality of life in patients undergoing treatment at the end of the intervention. Albumin (P<0.001) and hemoglobin (P<0.001) levels increased in the intervention group, while there were no significant changes in these variables of the control group. Serum levels of ferritin did not show significant changes in either the intervention or the control group. Conclusion: Identifying nutritional barriers in breast cancer patients and individual diet therapy based on these barriers and nutritional needs reduces nutritional barriers. Consequently, malnutrition would decline, and the quality of life may enhance in these patients.
背景:在癌症患者中,营养不良导致的体重下降对患者的治疗和生活质量有显著影响。本研究旨在确定适当的治疗策略,以控制化疗对乳腺癌患者的副作用,以改善其健康、生活质量和营养状况。方法前瞻性研究纳入70例正在接受化疗的胃癌患者,随机分为干预组(n=35)和对照组(n=35)。干预组根据他们的营养需要接受个体化饮食,为期8周,对照组接受关于化疗副作用的饮食建议。采用PG-SGA、营养障碍和QLQ-C30问卷评估营养不良、营养障碍和患者生活质量。在研究开始和结束时也对血清蛋白进行了评估。结果:干预组患者平均年龄为50.91±1.72岁,对照组平均年龄为51±1.35岁。根据PG-SGA问卷分类,68.5%的患者在基线时存在营养不良。干预组PG-SGA平均评分下降,说明患者营养状况有所改善。问卷QLQC30功能部分得分增加,症状部分得分降低,表明干预结束时接受治疗的患者生活质量有所改善。干预组白蛋白(P<0.001)和血红蛋白(P<0.001)水平升高,而对照组这些变量无显著变化。无论是干预组还是对照组,血清铁蛋白水平都没有明显变化。结论:识别乳腺癌患者的营养障碍,并根据这些障碍和营养需求进行个体化饮食治疗,可减少营养障碍。因此,营养不良将会减少,这些患者的生活质量可能会提高。
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引用次数: 1
Evaluation of Different Types of Pain in Patients with Breast Cancer 乳腺癌患者不同类型疼痛的评价
Pub Date : 2021-03-16 DOI: 10.18502/BCCR.V12I3.5769
S. Fakhim, S. Farahani, Hoda Pourkarim, Fateme Mousavi, M. Ahmadi, M. Azad
Background: Cancer, a common disease in the world, is considered the second cause of mortality in developed countries. In the management of symptoms created by breast cancer (BC), pain is the most important. So, this study aimed to evaluate different dimensions of pain in patients using the McGill Pain Questionnaire. In this way, physicians could perform effective treatment for patients.   Methods: This case study was done on BC patients aged 30-60 years old in some specialized cancer hospitals in Tehran. The utilized research instrument in this study was the McGill Pain Questionnaire. Data were analyzed by SPSS Software. Conclusion: According to these results, it is possible to use effective and better treatment to reduce BC patients’ pain.
背景:癌症是世界上常见的疾病,在发达国家被认为是第二大死亡原因。在乳腺癌(BC)症状的治疗中,疼痛是最重要的。因此,本研究旨在使用麦吉尔疼痛问卷评估患者不同维度的疼痛。这样,医生就可以对病人进行有效的治疗。方法:对德黑兰一些肿瘤专科医院的30-60岁BC患者进行病例研究。本研究使用的研究工具为麦吉尔疼痛问卷。数据采用SPSS软件进行分析。结论:根据这些结果,可以采用有效和更好的治疗方法来减轻BC患者的疼痛。
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引用次数: 0
Evaluation of Peritoneal Lavage for Gastric Cancer Staging in Patients Without Ascites Based on Cytology and Carcinoembryonic Antigen 基于细胞学和癌胚抗原的腹腔灌洗对无腹水胃癌分期的评价
Pub Date : 2021-03-16 DOI: 10.18502/BCCR.V12I3.5770
Fezzeh Elyasinia, F. Karimian, F. Samiei, E. Sadeghian
Background: Imaging, cytological examination of ascites (if present), laparosco- py, and peritoneal lavage are performed before surgery for gastric cancer staging. Peritoneal lavage aims to diagnose the microscopic presence of tumor cells on the peritoneal surface. Positive cytology may have a prognostic value that classifies the disorder as stage IV, in which the patient is no longer an elective surgical candidate. Thus, our study was designed to assess the ability of peritoneal lavage to stage gastric cancer in non-ascitic patients based on cytological evaluation and carcinoembryonic antigen (CEA) level measurement. Methods: In our prospective study, we examined gastric cancer patients who were candidates for elective surgery. Upon entering the abdominal cavity and before tu- mor manipulation, normal saline (500 ml) was applied, and the abdominal cavity was thoroughly dispersed. After three minutes, the fluid was drained and addressed to cytological analysis and CEA measurement by radioimmunoassay (RIA). Study var- iables including age, sex, family history, tumor position, pathology, staging, grading, the original tumor size, regional lymph node involvement, and distant metastases were recorded during the pre- and postoperative staging. The association between positive peritoneal lavage cytology and various patients’ characteristics was investigated. Results: In this study, 94 patients were screened. Due to lymphoma and gastrointes- tinal stromal tumor (GIST), two patients were excluded. We examined 92 patients, including 63 males (68.5 %) and 29 females (31.5 %). The mean age of patients was 58.52 ± 11.87 years. The most common tumor location was the esophagogastric junction. Moderately differentiated adenocarcinoma was the most frequent micro- scopic diagnosis. T3 was the most prevalent primary tumor size in 51 patients. Sev- enty-two patients (78.26%) were operable, of whom 18 (19.6 %) were positive for peritoneal lavage cytology. Positive cytology of peritoneal lavage was significantly related to tumor size, tumor grade, serosa/adjacent organ invasion (T4), laparoscopic staging findings, locally advanced disease (R0), and stage of the disease (P < 0.05). In the peritoneal lavage fluid, elevated CEA titers were significantly related to the high-grade tumor (P = 0.012).  Conclusion: Our study demonstrated that positive cytology and high CEA titers in peritoneal lavage fluid of gastric cancer patients without ascites are significantly correlated to the advanced stages.  
背景:胃癌分期术前应进行影像学检查、腹水细胞学检查(如有)、腹腔镜检查和腹腔灌洗。腹膜灌洗的目的是诊断腹膜表面的肿瘤细胞的显微镜存在。细胞学阳性可能具有将疾病分类为IV期的预后价值,其中患者不再是选择性手术候选人。因此,我们的研究旨在通过细胞学评估和癌胚抗原(CEA)水平测定来评估腹膜灌洗对非腹水患者胃癌分期的能力。方法:在我们的前瞻性研究中,我们检查了胃癌患者,他们是择期手术的候选人。在进入腹腔和进一步操作前,应用生理盐水(500 ml),腹腔彻底分散。三分钟后,排出液体,用放射免疫分析法(RIA)进行细胞学分析和CEA测定。研究变量包括年龄,性别,家族史,肿瘤位置,病理,分期,分级,原始肿瘤大小,区域淋巴结受累和远处转移,记录术前和术后分期。探讨腹膜灌洗细胞学阳性与患者各种特征的关系。结果:本研究共筛选94例患者。由于淋巴瘤和胃肠道间质瘤(GIST), 2例患者被排除。我们检查了92例患者,其中男性63例(68.5%),女性29例(31.5%)。患者平均年龄58.52±11.87岁。最常见的肿瘤位置是食管胃交界处。中分化腺癌是显微镜下最常见的诊断。在51例患者中,T3是最常见的原发肿瘤大小。72例(78.26%)可手术,其中18例(19.6%)腹膜灌洗细胞学阳性。腹膜灌洗细胞学阳性与肿瘤大小、肿瘤分级、浆膜/邻近脏器侵犯(T4)、腹腔镜分期、局部进展(R0)、疾病分期相关(P < 0.05)。在腹膜灌洗液中,CEA滴度升高与肿瘤高度相关(P = 0.012)。结论:无腹水的胃癌患者腹膜灌洗液细胞学阳性和CEA滴度高与胃癌的晚期有显著相关性。
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引用次数: 0
Performance Indicators of Breast Cancer Screening program Based on National Screening Guideline in Rural area of Rudsar City in Gilan Province, Iran. 伊朗吉兰省鲁德萨尔市农村地区基于国家筛查指南的乳腺癌筛查项目绩效指标
Pub Date : 2021-03-15 DOI: 10.18502/BCCR.V12I2.5753
F. Pakdaman, Sareh Shakerian
Background: According to the World Health Organization (WHO), the high prevalence of breast cancer mortality in the least developed countries is due to the diagnosis at late phases. Accordingly, cost-effective breast cancer screening plans are the most effective methods to control this cancer and increase women’s survival. Methods: This study aimed to evaluate the performance of the breast cancer screening program based on the guidelines of the Iran Ministry of Health on 14,493 eligible women in rural areas of Rudsar city in 2018-19. We calculated performance indicators such as target coverage, identification of the at-risk population, early diagnosis, referral index, and other statistical using SPSS 22 software. Results: Out of 14493 rural women aged 30-59 referred to health homes, 6992 women underwent breast cancer screening. Coverage of the program in the The target population coverage was estimated at 48%. Most high-risk cases were 46 years and older, and the lowest rate was in women of <35 years. We found Thethat results showed that 0.4% of the cases patients (n=27) were identified as the high-risk, and all (100%) referred to group according to the national guidelines with referral to a specialist for further evaluation. of 100%. All patients cases identified as high-risk groups atin the first phase of screening were found with BIRADS (Breast Imaging Reporting and Data System) 4 and 5 based on biopsy specimens. Conclusion: The low target population coverage and the cases with advanced breast cancer indicated the need for more attention and consideration in implementing programs and policies for preventable cancer by all organizations. In this regard, there is a need for relevant interventions and follow-up by health authorities.
背景:根据世界卫生组织(世卫组织)的资料,最不发达国家乳腺癌死亡率高是由于诊断较晚。因此,具有成本效益的乳腺癌筛查计划是控制这种癌症和提高妇女生存率的最有效方法。方法:本研究旨在评估2018- 2019年鲁德萨尔市农村地区14493名符合条件的妇女根据伊朗卫生部指南开展的乳腺癌筛查项目的效果。我们使用SPSS 22软件计算目标覆盖率、高危人群识别、早期诊断、转诊指数等绩效指标。结果:14493名30-59岁农村妇女转诊到卫生院,6992名妇女接受了乳腺癌筛查。该计划在目标人群中的覆盖率估计为48%。高危病例以46岁及以上的女性居多,<35岁的女性发病率最低。我们发现,结果显示0.4%的病例(n=27)被确定为高危患者,所有(100%)的患者根据国家指南转介给专科医生进行进一步评估。的100%。所有在第一阶段筛查中被确定为高危人群的患者都是根据活检标本使用BIRADS(乳腺成像报告和数据系统)4和5发现的。结论:低目标人群覆盖率和晚期乳腺癌病例表明,各组织在实施可预防癌症的方案和政策时需要更多的关注和考虑。在这方面,卫生当局有必要采取相关干预措施并采取后续行动。
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Basic & Clinical Cancer Research
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