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Silibinin Inhibits TGF-β-induced MMP-2 and MMP-9 Through Smad Signaling Pathway in Colorectal Cancer HT-29 Cells 水飞蓟宾通过Smad信号通路抑制TGF-β诱导的结直肠癌HT-29细胞中的MMP-2和MMP-9
Pub Date : 2021-03-15 DOI: 10.18502/BCCR.V12I2.5752
Z. Zare, Tina Nayerpour dizaj, Armaghan Lohrasbi, Zakieh Sadat Sheikhalishahi, Amirhooman Asadi, Mana Zakeri, F. Hosseinabadi, Omid Abazari, M. Abbasi, Parisa Khanicheragh
Background: Metastasis of cancer cells is the primary responsible for death in patients with colorectal cancer (CRC). Transforming growth factor-β (TGF-β)-induced matrix metalloproteinases (MMPs) are essential for the metastasis process. Silibinin is a natural compound extracted from the Silybum marianum that exhibits anti-neoplastic activity in cancer cell lines. In this study, we evaluated the effects of silibinin on MMP-2 and MMP-9 induced by TGF-β in human HT-29 CRC cell line and the potential mechanism underlying the effects. Methods: The present in vitro study was done on the HT-29 cell line. The HT-29 cell line was cultured in RPMI1640 and exposed to TGFβ (5 ng/ml) in the absence and presence of different concentrations of silibinin (10, 25, 50, and 100 μM). The effect of silibinin on HT-29 cell viability was measured with the MTT assay. A real-time polymerase chain reaction (Real-Time PCR) determined the relative mRNA expression of MMP-2 and MMP-9. Western blotting was employed to examine MMP-2 and MMP 9 protein expression and Smad2 phosphorylation. Results: Silibinin inhibits cell viability of HT-29 cell line at 24 hours in a dose-dependent manner. TGF-β increased the mRNA and protein expression of MMP-2, MMP-9, and phosphorylated Smad2 compared to controls. Pharmacological inhibition with silibinin markedly blocked TGF-β–induced MMP-2 and MMP-9 mRNA and protein expression and Smad2 phosphorylation. Conclusion: Silibinin decreased the cell viability of HT-29 cancer cells in a dose-dependent manner. Silibinin also inhibited TGF-β-stimulated MMP-2 and MMP-9 expression in HT-29 cells, possibly mediated with the Smad2 signaling pathway.
背景:肿瘤细胞转移是导致结直肠癌(CRC)患者死亡的主要原因。转化生长因子-β (TGF-β)诱导的基质金属蛋白酶(MMPs)在转移过程中至关重要。水飞蓟宾是从水飞蓟中提取的一种天然化合物,对癌细胞具有抗肿瘤活性。在本研究中,我们评估水飞蓟宾对TGF-β诱导的人HT-29 CRC细胞株MMP-2和MMP-9的影响及其潜在机制。方法:在HT-29细胞系上进行体外实验。HT-29细胞系在RPMI1640中培养,在不含和存在不同浓度水飞蓟宾(10、25、50和100 μM)的情况下暴露于TGFβ (5 ng/ml)中。MTT法测定水飞蓟宾对HT-29细胞活力的影响。实时聚合酶链反应(real-time PCR)检测MMP-2和MMP-9 mRNA的相对表达量。Western blotting检测MMP-2、MMP- 9蛋白表达及Smad2磷酸化水平。结果:水飞蓟宾对HT-29细胞株24小时细胞活力有一定的抑制作用,且呈剂量依赖性。与对照组相比,TGF-β增加了MMP-2、MMP-9和磷酸化Smad2的mRNA和蛋白表达。水飞蓟宾药理抑制显著阻断TGF-β诱导的MMP-2和MMP-9 mRNA和蛋白表达及Smad2磷酸化。结论:水飞蓟宾降低HT-29癌细胞的细胞活力呈剂量依赖性。水飞蓟宾还能抑制TGF-β刺激的HT-29细胞中MMP-2和MMP-9的表达,可能是通过Smad2信号通路介导的。
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引用次数: 12
Opium Carcinogenicity: A Systematic Review of Experimental Studies 鸦片致癌性:实验研究的系统综述
Pub Date : 2021-03-15 DOI: 10.18502/BCCR.V12I2.5756
Haniyeh Rafipour, E. Mohebbi, K. Zendehdel, S. Muhammadnejad, Paria Akbari, S. Hashemi, Kosar Nouri, F. Moradkhani, Tahereh Barati, S. Amanpour
Several epidemiological studies have reported that regular use of opium can be associated with an increased risk of developing cancers, including oesophageal, laryngeal, bladder, lung, and gastric cancer. In this systematic review, we aimed at investigating whether experimental studies support this finding and, if yes, how opium consumption can cause cancer. Most of the articles that have studied opium or its derivatives have found it as a carcinogen. However, due to the complex composition, different forms, and various ways of opium use, further comprehensive experimental studies are required. Using modern genomic and epigenomic methods seems to help determine the molecular mechanisms underlying opium carcinogenicity.
一些流行病学研究报告说,经常使用鸦片可能与患癌症的风险增加有关,包括食道癌、喉癌、膀胱癌、肺癌和胃癌。在这篇系统综述中,我们旨在调查实验研究是否支持这一发现,如果是的话,鸦片消费是如何导致癌症的。大多数研究鸦片及其衍生物的文章都发现它是一种致癌物质。然而,由于鸦片的成分复杂、形态各异、使用方式多样,需要进一步进行全面的实验研究。使用现代基因组学和表观基因组学方法似乎有助于确定鸦片致癌性的分子机制。
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引用次数: 1
Investigation of MRP1 and ABCG2 Gene Expression in Chronic Myeloid Leukemia (CML) Patients 慢性髓性白血病(CML)患者MRP1和ABCG2基因表达的研究
Pub Date : 2021-03-15 DOI: 10.18502/BCCR.V12I2.5755
Saeed Solali, Masoumeh Fardi, S. Almasi, M. Aliparasti
Background: This study evaluated and compared the quantitative expression of multidrug resistance-associated protein 1 (MRP1) and ATP-binding cassette subfamily G member 2 (ABCG2), two Multidrug Resistance (MDR) related genes, in 30 CML patients and 27 normal subjects. Methods: Total RNA was isolated from peripheral blood mononuclear cells (MNCs) using the Trizol reagent. Then cDNAs were synthesized. Gene expression was quantified using Real-Time PCR System. The relative expression of target genes was calculated using the 2-ΔΔCt method. Results: High expression of MRP1 and ABCG2 mRNAs were detected in the patient group. Intra-group comparisons also revealed increased expression of ABCG2 in Accelerated Phase (AP)-Blastic Crisis (BC) patients compared to Chronic Phase (CP) patients. At the same time, the increased expression of MRP1 in AP-BC patients was not statistically significant. Conclusion: Considering the broad spectrum of ATP Binding Cassette (ABC) transporter superfamily substrates, they can play an essential role in cell fate determination. High expression of MRP1 and ABCG2 genes can result in the efflux of therapeutic agents and subsequent reduction in their intracellular concentration. This mechanism finally protects cells from the therapeutic effects of medications. On the other hand, these transporters can export growth factors out of the cell. Such exported molecules may have a growth-inducing effect on adjacent cells. These are the possible mechanisms for the participation of MRP1 and ABCG2 genes in conferring drug resistance to CML cells.
背景:本研究评估并比较了30例CML患者和27例正常人多药耐药(MDR)相关基因MRP1和atp结合盒亚家族G成员2 ABCG2的定量表达。方法:采用Trizol试剂从外周血单个核细胞(MNCs)中分离总RNA。然后合成cdna。采用Real-Time PCR系统定量检测基因表达。用2-ΔΔCt法计算靶基因的相对表达量。结果:患者组MRP1和ABCG2 mrna高表达。组内比较还显示,与慢性期(CP)患者相比,加速期(AP)-母细胞危象(BC)患者中ABCG2的表达增加。同时,MRP1在AP-BC患者中的表达升高无统计学意义。结论:考虑到ATP Binding Cassette (ABC)转运体超家族底物的广谱性,它们可能在决定细胞命运中发挥重要作用。MRP1和ABCG2基因的高表达可导致治疗剂的外排和随后的细胞内浓度降低。这种机制最终保护细胞不受药物治疗效果的影响。另一方面,这些转运蛋白可以将生长因子输出到细胞外。这种输出的分子可能对邻近细胞有诱导生长的作用。这些都是MRP1和ABCG2基因参与CML细胞耐药的可能机制。
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引用次数: 0
The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line 胡椒碱对乳腺癌MCF-7细胞系中MMP-9、VEGF和E-cadherin表达的影响
Pub Date : 2021-03-15 DOI: 10.18502/BCCR.V12I3.5767
Z. Zare, Tina Nayerpour dizaj, Armaghan Lohrasbi, Zakieh Sadat Sheikhalishahi, Mohammad Panji, F. Hosseinabadi, Vajiheh Najafi, Omid Abazari, M. Abbasi, Parisa Khanicheragh
Background: Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and E-cadherin play a vital role in the behavior of angiogenesis, metastasis, and invasion of breast tumor cells. Piperine, the main component of Piper Nigrum, has shown anti-cancer properties in various malignancies. This Study investigates the potential effect of piperine on MMP-9, E-cadherin, and VEGF expression in breast cancer MCF-7 cell line. Methods: MTT assay was applied to assess the viability of MCF-7 cells. The mRNA levels of MMP-9, VEGF, and E-cadherin were assayed by qRT-PCR. Western blot was performed to identify the protein level of MMP-9. Results: MTT assay results showed that piperine treatment (5, 10, 25, 50, 75, and 100 μM) for 24 hours effectively inhibited cell viability of MCF-7 cells as compared with the control group. Furthermore, the gene expression of VEGF, MMP-9, and E-cadherin was dose-dependently suppressed by piperine treatment (5, 10 and 25 μM) (P<0.05; P<0.01). The results also indicated that piperine (5, 10, and 25 μM) significantly suppressed MMP-9 protein expression after 24 hours of piperine treatment (P<0.01). Conclusion: These results suggest that piperine may prevent angiogenesis, migration, and invasion of MCF-7 cells by suppressing MMP-9 and VEGF, and by inducing E-cadherin expression. Hence, it may be a suitable candidate for designing new drugs in cancer therapy.
背景:血管内皮生长因子(VEGF)、基质金属蛋白酶-9 (MMP-9)和E-cadherin在乳腺肿瘤细胞的血管生成、转移和侵袭行为中起重要作用。胡椒碱是胡椒的主要成分,对多种恶性肿瘤具有抗癌作用。本研究探讨胡椒碱对乳腺癌MCF-7细胞系中MMP-9、E-cadherin和VEGF表达的潜在影响。方法:采用MTT法测定MCF-7细胞活力。采用qRT-PCR检测MMP-9、VEGF、E-cadherin mRNA表达水平。Western blot检测MMP-9蛋白表达水平。结果:MTT实验结果显示,胡椒碱(5、10、25、50、75和100 μM)处理24h后,MCF-7细胞活力明显受到抑制。此外,胡椒碱处理(5、10和25 μM)对VEGF、MMP-9和E-cadherin的基因表达呈剂量依赖性抑制(P<0.05;P < 0.01)。胡椒碱(5 μM、10 μM和25 μM)对MMP-9蛋白的表达有显著抑制作用(P<0.01)。结论:胡椒碱可能通过抑制MMP-9、VEGF及诱导E-cadherin表达抑制MCF-7细胞的血管生成、迁移和侵袭。因此,它可能是设计癌症治疗新药的合适候选者。
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引用次数: 3
Lesson learned from a Pilot Project in Rudsar city in Gilan province for Breast Cancer Screening in Iran 伊朗吉兰省鲁德萨尔市乳腺癌筛查试点项目的经验教训
Pub Date : 2021-03-15 DOI: 10.18502/BCCR.V12I2.5757
K. Zendehdel
The article's abstract is not available.
这篇文章的摘要没有。
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引用次数: 0
Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study 伊朗东北部宫颈癌的主要危险因素:来自病例对照研究的证据
Pub Date : 2021-03-15 DOI: 10.18502/BCCR.V12I2.5754
F. H. Shandiz, Alireza Pasdar, F. Afzaljavan, Zohre Takalluo, M. Mofrad
Background: Cervical cancer is a preventable cancer with various risk factors. In this study, we assessed different risk factors involved in invasive cervical cancer in the Northeast of Iran. Methods: In a case-control study, 99 patients with advanced cervical cancer were compared to 102 healthy, normal women. Cervical cancer risk factors were documented for these groups using a questionnaire and available medical notes. Univariate analysis was done for each risk factor, followed by multivariate regression analysis, to evaluate the most powerful risk factors after adjustment. Results: Multivariate model indicated that sexual transmitted diseases (STD) [p<0.001; OR=7.88, 95% CI (2.59-23.93)], age at first intercourse ≤16 [p=0.048; OR=6.22, 95% CI (1.06-36.51)] and age [p=0.001; OR= 1.11, 95% CI (1.04-1.18)] were independently significant risk factors for cervical cancer. Conclusion: According to this survey, the significant influence of major risk factors, including STD, age at first intercourse, and age itself, has been underlined. Moreover, increasing the social knowledge and educating people to prevent highrisk sexual behaviors, HPV testing, and routine use of HPV vaccine, which is nowadays regarded as a preventive measure in cervical cancer, may also be needed to be implemented in our prevention program.
背景:宫颈癌是一种具有多种危险因素的可预防癌症。在这项研究中,我们评估了伊朗东北部浸润性宫颈癌的不同危险因素。方法:在一项病例对照研究中,99例晚期宫颈癌患者与102例健康正常妇女进行比较。通过问卷调查和现有的医疗记录,记录了这些群体的宫颈癌风险因素。对各危险因素进行单因素分析,再进行多因素回归分析,以评价调整后影响最大的危险因素。结果:多变量模型显示性传播疾病(STD)患病率[p<0.001;OR=7.88, 95% CI(2.59 ~ 23.93)],初次性行为年龄≤16岁[p=0.048;OR=6.22, 95% CI(1.06-36.51)]和年龄[p=0.001;OR= 1.11, 95% CI(1.04-1.18)]是宫颈癌的独立显著危险因素。结论:调查结果显示,性病、初次性行为年龄、年龄本身等主要危险因素对性行为有显著影响。此外,增加社会知识和教育人们预防高危性行为,HPV检测和常规使用HPV疫苗,这是目前被认为是宫颈癌的预防措施,也可能需要在我们的预防计划中实施。
{"title":"Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study","authors":"F. H. Shandiz, Alireza Pasdar, F. Afzaljavan, Zohre Takalluo, M. Mofrad","doi":"10.18502/BCCR.V12I2.5754","DOIUrl":"https://doi.org/10.18502/BCCR.V12I2.5754","url":null,"abstract":"Background: Cervical cancer is a preventable cancer with various risk factors. In this study, we assessed different risk factors involved in invasive cervical cancer in the Northeast of Iran. Methods: In a case-control study, 99 patients with advanced cervical cancer were compared to 102 healthy, normal women. Cervical cancer risk factors were documented for these groups using a questionnaire and available medical notes. Univariate analysis was done for each risk factor, followed by multivariate regression analysis, to evaluate the most powerful risk factors after adjustment. Results: Multivariate model indicated that sexual transmitted diseases (STD) [p<0.001; OR=7.88, 95% CI (2.59-23.93)], age at first intercourse ≤16 [p=0.048; OR=6.22, 95% CI (1.06-36.51)] and age [p=0.001; OR= 1.11, 95% CI (1.04-1.18)] were independently significant risk factors for cervical cancer. Conclusion: According to this survey, the significant influence of major risk factors, including STD, age at first intercourse, and age itself, has been underlined. Moreover, increasing the social knowledge and educating people to prevent highrisk sexual behaviors, HPV testing, and routine use of HPV vaccine, which is nowadays regarded as a preventive measure in cervical cancer, may also be needed to be implemented in our prevention program.","PeriodicalId":8706,"journal":{"name":"Basic & Clinical Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76582226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Water-pipe as a Risk Factor for Genital Warts? A Case Report 水管是生殖器疣的危险因素?病例报告
Pub Date : 2021-03-14 DOI: 10.18502/BCCR.V11I3.5718
Faezeh Ghaemdoust, A. Nahvijou, F. Farzaneh
Background: Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the world. HPV infection can cause some types of cancer including female genital cancers (cervical cancer, vulvar) and male genital cancer as well as oropharyngeal cancers and genital warts. Cigarette smoking is a risk factor of cervical cancer or genital warts. Case presentation: This case report present a young woman who developed extensive genital warts a year after starting water-pipe smoking. These genital warts healed spontaneously after cessation of water-pipe smoking. Conclusion: The primary hypothesis that could be propounded, is that water-pipe smoke plays a role as an independent risk factor in developing genital warts, similar to cigarette smoke. In addition, water pipe smking may transmit different infections, including HPV infection through sharing the mouth tips of the water pipe between
背景:人乳头瘤病毒(HPV)感染是世界上最常见的性传播感染。人乳头瘤病毒感染可导致某些类型的癌症,包括女性生殖器癌症(宫颈癌、外阴)和男性生殖器癌症,以及口咽癌和生殖器疣。吸烟是宫颈癌或生殖器疣的一个危险因素。病例介绍:这个病例报告提出了一个年轻的妇女谁发展广泛的生殖器疣一年后开始吸烟水烟。这些生殖器疣在戒烟后自然愈合。结论:可以提出的主要假设是,与香烟烟雾类似,水烟烟雾在生殖器疣的发生中起着独立的危险因素作用。此外,水管吸烟可能会传播不同的感染,包括HPV感染通过共用水管嘴尖
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引用次数: 5
Cryopreservation Options to Preserve Fertility in Female Cancer Patients: Available Clinical Practice and Investigational Strategies from the Oncology Guidelines Point of View 冷冻保存选择以保持女性癌症患者的生育能力:从肿瘤学指南的角度来看,可用的临床实践和研究策略
Pub Date : 2021-03-14 DOI: 10.18502/BCCR.V12I1.5726
L. Mirzaeian, Haniyeh Rafipour, S. Hashemi, S. Zabihzadeh, S. Amanpour
In recent years, advances in cancer treatment have improved the survival rate of cancer patients significantly. However, destructive damage to ovaries due to the therapies or cancer itself can cause different degrees of infertility in women of reproductive age that can affect their quality of life seriously. In this study, fertility cryopreservation options for female cancer patients in oncology guidelines were reviewed. Cryopreservation methods have a long history in reproductive biology and oncology. However, embryo and oocyte cryopreservation were the eligible restoration strategies in clinical oncology practice. Ovarian tissue cryopreservation (OTC) is the latest option recommended for fertility preservation in pre-pubertal and adult patients who cannot delay their treatment or in whom taking IVF hormones may have adverse effects on their cancer. Reports show that frozen-thawed ovarian tissue transplantation has led to more than 130 live births so far in patients, most of whom were cancer patients. Although OTC is indeed generally recognized as an investigational method, it is recommended in some important guidelines, such as ASCO 2018. Therefore, based on many clinical pieces of evidence , it is predicted that the investigational label will soon be removed, and OTC might be considered as one of the main fertility preservation options for female cancer patients in clinical oncology practice.
近年来,癌症治疗的进步显著提高了癌症患者的生存率。然而,由于治疗或癌症本身对卵巢的破坏性损伤可导致育龄妇女不同程度的不孕症,严重影响她们的生活质量。本研究综述了肿瘤学指南中女性癌症患者生育能力冷冻保存的选择。低温保存方法在生殖生物学和肿瘤学领域有着悠久的历史。然而,胚胎和卵母细胞冷冻保存是临床肿瘤实践中合适的恢复策略。卵巢组织冷冻保存(OTC)是最新推荐的生育能力保存的选择,在青春期前和成年患者不能延迟他们的治疗或服用体外受精激素可能对他们的癌症有不利影响。报告显示,迄今为止,冷冻解冻卵巢组织移植已导致130多名患者活产,其中大多数是癌症患者。虽然OTC确实被普遍认为是一种研究方法,但在一些重要的指南(如ASCO 2018)中推荐使用。因此,基于许多临床证据,我们预测该临床标签将很快被移除,OTC可能被认为是临床肿瘤学实践中女性癌症患者的主要生育能力保存选择之一。
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引用次数: 4
Inutility of IMP3 Marker in Differentiating Hodgkin Lymphoma from Large Cell Lymphoma IMP3标记物在霍奇金淋巴瘤与大细胞淋巴瘤鉴别中的作用
Pub Date : 2021-03-14 DOI: 10.18502/BCCR.V12I1.5730
A. Z. Mehrjerdi, M. Ahmadi
Background: Hodgkin’s lymphoma is one of the most commonly diagnosed lym- phomas in Western society. Today Reed-Sternberg cells are identified by positive staining of several biomarkers. The IMP3 (insulin-like growth factor II m-RNA-bind- ing protein 3) marker is a member of the insulin-like growth factor II mRNA binding protein family that has been suggested as a diagnostic marker in some epithelial malignancies. In this study, we aimed to evaluate the expression profile of IMP3 in Hodgkin’s lymphoma patients and compare it with those with large cell lymphoma. Methods: In this study, patients diagnosed with Hodgkin’s lymphoma between 2016 and 2018 were recruited. For the control group, patients diagnosed with large cell lymphoma were chosen. Paraffin blocks were collected and cut by a microtome machine. Immunohistochemical staining was performed on the slides for the IMP3 marker, using the Envision method. The color intensity was divided into four groups, and data on age, gender, staining intensity, sampling rate, and staining pattern en- tered at the end of the checklists. The collected data were analyzed using SPSS 19 software. The paired t-test has was employed, and a significant statistical level of 0.05 was considered in all tests. Results: In this study, 145 patients in a wide range of 5 to 84 years (the mean age = 41 ± 17 years) were studied. Fifty-three patients were diagnosed with diffuse large B-cell lymphoma (36.6%), 4 cases (2.8%) with anaplastic large cell lymphoma and 88 cases with (60.7%) Hodgkin’s lymphoma. Among 145 patients in the current study, 143 patients (98.6%) were positive for IMP3. IMP3 was positive in all patients with Hodgkin’s lymphoma and anaplastic large cell lymphoma, and only 2 cases of diffuse large B-cell lymphoma were negative for this maker, in whom severe ne- crosis was noted. Consequently, there is not a vivid difference between Hodgkin’s lymphoma and non-Hodgkin’s lymphoma (p-value=0.153) Conclusion: The marker is positive for Hodgkin’s lymphoma with a negative back- ground and may be used as a supplementary marker along with CD15 and CD30 to detect neoplastic cells. However, it cannot help differentiate it from large cell lym- phomas because it is also positive for non-Hodgkin lymphomas.
背景:霍奇金淋巴瘤是西方社会最常见的淋巴瘤之一。今天,Reed-Sternberg细胞是通过几种生物标志物的阳性染色来鉴定的。IMP3(胰岛素样生长因子II m- rna结合蛋白3)标记物是胰岛素样生长因子II mRNA结合蛋白家族的成员,已被认为是一些上皮恶性肿瘤的诊断标记物。在本研究中,我们旨在评估IMP3在霍奇金淋巴瘤患者中的表达谱,并将其与大细胞淋巴瘤患者进行比较。方法:本研究招募2016年至2018年诊断为霍奇金淋巴瘤的患者。对照组选择确诊为大细胞淋巴瘤的患者。石蜡块收集,切片机切割。使用Envision方法对载玻片进行IMP3标记物的免疫组织化学染色。颜色强度分为四组,年龄,性别,染色强度,采样率和染色模式的数据记录在检查表的最后。采用SPSS 19软件对收集的数据进行分析。采用配对t检验,所有检验均考虑0.05的显著性统计水平。结果:本研究纳入145例患者,年龄5 ~ 84岁,平均年龄41±17岁。弥漫性大b细胞淋巴瘤53例(36.6%),间变性大细胞淋巴瘤4例(2.8%),霍奇金淋巴瘤88例(60.7%)。在本研究的145例患者中,143例(98.6%)患者IMP3阳性。所有霍奇金淋巴瘤和间变性大细胞淋巴瘤患者均检测到IMP3阳性,仅2例弥漫性大b细胞淋巴瘤患者检测到该抗原阴性,并伴有严重的坏死。结论:该标志物在背景阴性的霍奇金淋巴瘤中呈阳性,可与CD15、CD30一起作为肿瘤细胞检测的辅助标志物。然而,它不能帮助区分大细胞淋巴瘤,因为它对非霍奇金淋巴瘤也呈阳性。
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引用次数: 1
Application of Mathematical Model of Cancer Treatment by Radiotherapy 肿瘤放疗治疗数学模型的应用
Pub Date : 2021-03-14 DOI: 10.18502/BCCR.V11I3.5716
Seyed Mehdi Hosseini Motlagh, Faeze Lari Motefaker
The aim of this study is achieve an analysis of the mathematical model governing radiotherapy as well as to achieve the concentration of healthy and cancerous cells to reduce the length of treatment and less damage to cancer treatment by this type of therapy. In order to obtain this, we used the latest mathematical radiotherapy model based on the Lotka-Volterra competitive equations and the Adomian decomposition method that is the one of the most advanced analytical solutions to solve differential equations to attain our goal. The calculation of the Adomian decomposition method was applied to the mathematical model governing radiotherapy, and then the concentration of healthy and cancerous cells was achieved with a very good approximation. Comparison of the behavior of healthy and cancerous cells concentrations based on experimental cases and the behavior of healthy and cancerous cells concentrations based on computations express the correctness of the work. ADM indicates the concentration of healthy and cancerous cells during the treatment stage and the no treatment stage can be effective in improving the modeling based on the competitive model of the Lotka-Volterra equations, which results in the reduction of the use of diagnostic devices, less radiation, the faster treatment process and decreasing the cost of treatment for patients and governments.
本研究的目的是实现对控制放射治疗的数学模型的分析,以及实现健康细胞和癌细胞的浓度,以减少治疗时间和减少这种类型治疗对癌症治疗的损害。为了达到这个目的,我们使用了最新的基于Lotka-Volterra竞争方程的放射治疗数学模型和最先进的求解微分方程的解析解之一Adomian分解方法来实现我们的目标。将Adomian分解法的计算应用于控制放射治疗的数学模型中,然后以很好的近似值获得健康细胞和癌细胞的浓度。基于实验案例的健康细胞和癌细胞浓度行为的比较以及基于计算的健康细胞和癌细胞浓度行为的比较表明了工作的正确性。ADM表明,健康细胞和癌细胞在治疗阶段和未治疗阶段的浓度可以有效地改进基于Lotka-Volterra方程的竞争模型的建模,从而减少诊断设备的使用,减少辐射,加快治疗过程,降低患者和政府的治疗成本。
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引用次数: 0
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Basic & Clinical Cancer Research
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