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Forming bootstrap confidence intervals and examining bootstrap distributions of standardized coefficients in structural equation modelling: A simplified workflow using the R package semboottools. 在结构方程建模中形成自举置信区间并检查标准化系数的自举分布:使用R包semboottools的简化工作流。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-16 DOI: 10.3758/s13428-025-02911-z
Wendie Yang, Shu Fai Cheung

Standardized coefficients - including factor loadings, correlations, and indirect effects - are fundamental to interpreting structural equation modeling (SEM) results in psychology. However, they often exhibit skewed sampling distributions in finite samples, which are not captured by conventional symmetric confidence intervals (CIs). Methods such as bootstrap CI that do not impose symmetry are more appropriate for these coefficients. Despite its popularity, the widely used R package lavaan (version 0.6-19 or earlier) provides limited bootstrap support for standardized coefficients. Specifically, its function standardizedSolution() uses the delta method for CIs and lacks bootstrap p values. It provides a flexible and powerful function, bootstrapLavaan(), for bootstrapping, and it can be used to form bootstrap CIs for the standardized coefficients. However, this function requires a certain level of R coding skills. Moreover, no built-in functions are available to inspect bootstrap distributions, which are recommended for assessing the stability of the bootstrap estimates. To address these limitations, we developed the semboottools R package, which provides a simple workflow in SEM to form bootstrap confidence intervals for unstandardized and standardized estimates of model and user-defined parameters. It allows researchers to generate percentile or bias-corrected bootstrap CIs, standard errors, asymmetric p values, compare the bootstrap CIs with other CI methods (e.g., delta method), and visualize the distributions of bootstrap estimates - with minimal coding effort. We believe the tool can facilitate researchers in easily forming bootstrap CIs, comparing different CI methods to assess the need for bootstrapping, and examining the distribution of bootstrap estimates to assess their stability.

标准化系数——包括因素负荷、相关性和间接影响——是解释心理学结构方程建模(SEM)结果的基础。然而,它们通常在有限样本中表现出倾斜的抽样分布,这是传统的对称置信区间(ci)所不能捕获的。不强加对称的方法,如自举CI,更适合这些系数。尽管它很流行,但广泛使用的R包lavaan(版本0.6-19或更早)对标准化系数提供了有限的引导支持。具体来说,它的函数standzedsolution()对ci使用delta方法,并且缺少自举p值。它为自举提供了一个灵活而强大的函数bootstrapLavaan(),它可以用来形成标准化系数的自举ci。然而,这个功能需要一定程度的R编码技能。此外,没有可用于检查引导分布的内置函数,建议使用这些函数来评估引导估计的稳定性。为了解决这些限制,我们开发了semboottools R包,它在SEM中提供了一个简单的工作流,可以为模型和用户定义参数的非标准化和标准化估计形成自引导置信区间。它允许研究人员生成百分位或偏差校正的自举CI,标准误差,不对称p值,将自举CI与其他CI方法(例如,delta方法)进行比较,并可视化自举估计的分布-只需最少的编码工作。我们相信该工具可以帮助研究人员轻松地形成自举CI,比较不同的CI方法来评估自举的必要性,并检查自举估计的分布以评估其稳定性。
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引用次数: 0
Virtual agents as a scalable tool for diverse, robust gesture recognition. 虚拟代理作为一种可扩展的工具,用于各种鲁棒的手势识别。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-16 DOI: 10.3758/s13428-025-02914-w
Lisa Loy, James P Trujillo, Floris Roelofsen

Gesture recognition technology is a popular area of research, offering applications in many fields, including behaviour research, human-computer interaction (HCI), medical research, and surveillance culture, among others. However, the large quantity of data needed to train a recognition algorithm is not always available, and differences between the training set and one's own research data in factors such as recording conditions and participant characteristics may hinder transferability. To address these issues, we propose training and testing recognition algorithms on virtual agents, a tool that has not yet been used for this purpose in multimodal communication research. We provide an example use case with step-by-step instructions, using mocap data to animate a virtual agent and create customised lighting conditions, backgrounds, and camera angles, creating a virtual agent-only dataset to train and test a gesture recognition algorithm. This approach also allows us to assess the impact of particular features, such as background and lighting. Our best-performing model in optimal background and lighting conditions achieved accuracy of 85.9%. When introducing background clutter and reduced lighting, the accuracy dropped to 71.6%. When testing the virtual agent-trained model on images of humans, the accuracy of target handshape classification ranged from 72% to 95%. The results suggest that training an algorithm on artificial data (1) is a resourceful, convenient, and effective way to customise algorithms, (2) potentially addresses issues of data sparsity, and (3) can be used to assess the impact of many contextual and environmental factors that would not be feasible to systematically assess using human data.

手势识别技术是一个受欢迎的研究领域,在许多领域都有应用,包括行为研究、人机交互(HCI)、医学研究和监测文化等。然而,训练识别算法所需的大量数据并不总是可用的,并且训练集与自己的研究数据在记录条件和参与者特征等因素上的差异可能会阻碍可转移性。为了解决这些问题,我们提出了在虚拟代理上训练和测试识别算法,这是一种在多模态通信研究中尚未用于此目的的工具。我们提供了一个示例用例,逐步说明,使用动作捕捉数据来动画虚拟代理,并创建定制的照明条件,背景和相机角度,创建一个虚拟代理专用数据集来训练和测试手势识别算法。这种方法还允许我们评估特定特征的影响,例如背景和照明。在最佳背景和光照条件下,我们表现最好的模型达到了85.9%的准确率。当引入背景杂波和减少照明时,精度下降到71.6%。当在人类图像上测试虚拟智能体训练模型时,目标手型分类的准确率在72%到95%之间。结果表明,在人工数据上训练算法(1)是定制算法的一种资源丰富、方便和有效的方式,(2)潜在地解决了数据稀疏性问题,(3)可用于评估许多上下文和环境因素的影响,这些因素无法使用人类数据进行系统评估。
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引用次数: 0
A mouse-tracking classification task to measure the unhealthy = tasty intuition. 一个追踪老鼠的分类任务来衡量不健康=美味的直觉。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-16 DOI: 10.3758/s13428-025-02927-5
Jonathan D'hondt, Barbara Briers

Understanding food preferences plays a crucial role in addressing both health concerns, such as obesity, and environmental concerns, such as climate change. Recognizing the impact of lay beliefs on food preferences is essential in addressing these challenges. One prevalent belief is the "unhealthy = tasty intuition" (UTI), the belief that taste and health in food do not go together. While self-report scales and behavioral tasks are commonly used to measure such beliefs, they have distinct methodological purposes: scales are better suited for assessing stable, trait-like constructs, whereas tasks capture more dynamic processes and are well suited for experimental manipulation. This paper introduces a mouse-tracking classification task that provides a process-based behavioral index of UTI, providing a novel approach for assessing implicit beliefs about the relationship between taste and health in food. Three studies validate the task, demonstrating correlations between explicit UTI scores and task performance. Additionally, the task predicts actual food consumption and, importantly, exhibits sensitivity to contextual manipulations. Because this task can be adapted to measure other beliefs, it is a valuable tool for researchers working on individual lay beliefs and decision-making processes. To that end, a template of the task is provided to help other researchers build on this work.

了解食物偏好在解决健康问题(如肥胖)和环境问题(如气候变化)方面起着至关重要的作用。认识到世俗信仰对食物偏好的影响对于应对这些挑战至关重要。一种流行的观点是“不健康=美味的直觉”(UTI),认为食物的味道和健康是不相容的。虽然自我报告量表和行为任务通常用于测量这种信念,但它们有不同的方法目的:量表更适合评估稳定的、类似特征的结构,而任务捕捉更多的动态过程,更适合实验操作。本文介绍了一种基于过程的UTI行为指数的小鼠跟踪分类任务,为评估食物中味道与健康关系的内隐信念提供了一种新的方法。三项研究验证了该任务,证明了显式UTI分数与任务绩效之间的相关性。此外,该任务预测实际的食物消耗,重要的是,显示出对上下文操纵的敏感性。因为这项任务可以用来衡量其他信念,所以对于研究个人信念和决策过程的研究人员来说,它是一个有价值的工具。为此,提供了一个任务模板,以帮助其他研究人员在此基础上进行工作。
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引用次数: 0
Bayesian hierarchical cognitive modeling with the EMC2 package. 使用EMC2包的贝叶斯层次认知建模。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-12 DOI: 10.3758/s13428-025-02869-y
Niek Stevenson, Michelle C Donzallaz, Reilly J Innes, Birte U Forstmann, Dora Matzke, Andrew Heathcote

EMC2 is an R package that provides a comprehensive five-phase workflow for Bayesian hierarchical analysis of cognitive models of choice. In the design phase, EMC2 bridges the gap between standard regression analyses and cognitive modeling through linear-model specifications for cognitive-model parameters. In the Bayesian specification and sampling phases, the package provides flexible priors, hierarchical structures, and efficient sampling algorithms, enabling fast, user-friendly estimation of computationally intensive cognitive models. In the final two phases, EMC2 provides a suite of functions for model criticism and inference. Using two leading evidence-accumulation models for illustration, we provide a tutorial on the EMC2-based workflow that eases and guides the process of specifying, evaluating, refining, comparing, and interpreting Bayesian hierarchical cognitive models.

EMC2是一个R包,它为选择的认知模型的贝叶斯层次分析提供了一个全面的五阶段工作流。在设计阶段,EMC2通过认知模型参数的线性模型规范弥合了标准回归分析和认知建模之间的差距。在贝叶斯规范和采样阶段,该包提供了灵活的先验、分层结构和有效的采样算法,实现了对计算密集型认知模型的快速、用户友好的估计。在最后两个阶段,EMC2提供了一套用于模型批评和推理的功能。使用两个领先的证据积累模型进行说明,我们提供了一个关于基于emc2的工作流的教程,该工作流简化并指导了指定、评估、精炼、比较和解释贝叶斯分层认知模型的过程。
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引用次数: 0
Collecting, detecting, and handling non-wear intervals in longitudinal light exposure data. 收集、检测和处理纵向光照数据中的非磨损间隔。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-12 DOI: 10.3758/s13428-025-02823-y
Carolina Guidolin, Johannes Zauner, Steffen Lutz Hartmeyer, Manuel Spitschan

In field studies using wearable light loggers, participants often need to remove the devices, resulting in non-wear intervals of varying and unknown duration. Accurate detection of these intervals is an essential step during data pre-processing. Here, we deployed a multi-modal approach to collect non-wear time during a longitudinal light exposure collection campaign and systematically compare non-wear detection strategies. Healthy participants (n = 26; mean age 28 ± 5 years, 14F) wore a near-corneal plane light logger for 1 week and reported non-wear events in three ways: pressing an "event marker" button on the light logger, placing it in a black bag, and using an app-based Wear log. Wear log entries, checked twice daily, served as ground truth for non-wear detection, showing that non-wear time constituted 5.4 ± 3.8% (mean ± SD) of total participation time. Button presses at the start and end of non-wear intervals were identified in >85.4% of cases when considering time windows beyond 1 min for detection. To detect non-wear intervals based on black bag use and lack of motion, we employed an algorithm that detects clusters of low illuminance and clusters of low activity. Performance was higher for illuminance (F1 = 0.78) than for activity (F1 = 0.52). Light exposure metrics derived from the full dataset, a dataset filtered for non-wear based on self-reports, and a dataset filtered for non-wear using the low illuminance clusters detection algorithm showed minimal differences. Our results highlight that while non-wear detection may be less critical in high-compliance cohorts, systematically collecting and detecting non-wear intervals is feasible and important for ensuring robust data pre-processing.

在使用可穿戴式光记录仪的现场研究中,参与者经常需要移除设备,导致不磨损的时间间隔变化且持续时间未知。准确检测这些区间是数据预处理过程中必不可少的一步。在这里,我们部署了一种多模式方法来收集纵向光暴露收集活动中的非磨损时间,并系统地比较了非磨损检测策略。健康参与者(n = 26,平均年龄28±5岁,14岁)佩戴近角膜平面光记录仪1周,并通过三种方式报告非磨损事件:按下光记录仪上的“事件标记”按钮,将其放入黑色袋子中,并使用基于应用程序的Wear日志。每天检查两次的磨损日志条目作为非磨损检测的基本事实,显示非磨损时间占总参与时间的5.4±3.8% (mean±SD)。当考虑超过1分钟的检测时间窗口时,在非磨损间隔的开始和结束时按下按钮的概率为85.4%。为了检测基于黑袋使用和缺乏运动的非磨损间隔,我们采用了一种检测低照度簇和低活动簇的算法。照度(F1 = 0.78)优于活度(F1 = 0.52)。来自完整数据集的光暴露指标,基于自我报告的非磨损过滤数据集,以及使用低照度簇检测算法过滤的非磨损数据集显示出最小的差异。我们的研究结果强调,虽然非磨损检测在高依从性队列中可能不那么重要,但系统地收集和检测非磨损间隔对于确保稳健的数据预处理是可行的,也是重要的。
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引用次数: 0
HR-ACT (Human-Robot Action) Database: Communicative and noncommunicative action videos featuring a human and a humanoid robot. HR-ACT(人-机器人动作)数据库:具有人类和类人机器人的交流和非交流动作视频。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-12 DOI: 10.3758/s13428-025-02910-0
Tuǧçe Nur Pekçetin, Gaye Aşkın, Şeyda Evsen, Tuvana Dilan Karaduman, Badel Barinal, Jana Tunç, Cengiz Acarturk, Burcu A Urgen

We present the HR-ACT (Human-Robot Action) Database, a comprehensive collection of 80 standardized videos featuring matched communicative and noncommunicative actions performed by both a humanoid robot (Pepper) and a human actor. We describe the creation of 40 action exemplars per agent, with actions executed in a similar manner, timing, and number of repetitions. The database includes detailed normative data collected from 438 participants, providing metrics on action identification, confidence ratings, communicativeness ratings, meaning clusters, and H values (an entropy-based measure reflecting response homogeneity). We provide researchers with controlled yet naturalistic stimuli in multiple formats: videos, image frames, and raw animation files (.qanim). These materials support diverse research applications in human-robot interaction, cognitive psychology, and neuroscience. The database enables systematic investigation of action perception across human and robotic agents, while the inclusion of raw animation files allows researchers using Pepper robots to implement these actions for real-time experiments. The full set of stimuli, along with comprehensive normative data and documentation, is publicly available at https://osf.io/8vsxq/ .

我们介绍了HR-ACT(人-机器人动作)数据库,这是一个全面的80个标准化视频的集合,其中包括由人形机器人(Pepper)和人类演员表演的匹配的交流和非交流动作。我们描述了每个代理40个动作范例的创建,这些动作以相似的方式、时间和重复次数执行。该数据库包括从438名参与者收集的详细规范数据,提供了行动识别、信心评级、沟通评级、意义集群和H值(一种基于熵的反映反应同质性的度量)的指标。我们为研究人员提供多种格式的受控但自然的刺激:视频,图像帧和原始动画文件(.qanim)。这些材料支持在人机交互、认知心理学和神经科学方面的各种研究应用。数据库可以系统地研究人类和机器人代理的动作感知,同时包含原始动画文件,使研究人员可以使用Pepper机器人实现这些实时实验的动作。整套刺激方案以及全面的规范性数据和文件可在https://osf.io/8vsxq/上公开获取。
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引用次数: 0
Speech onset time at home or in the lab: The role of testing environment and experimenter presence. 在家或在实验室的言语开始时间:测试环境和实验者在场的作用。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-09 DOI: 10.3758/s13428-025-02918-6
Giorgio Piazza, Natalia Kartushina, Christoforos Souganidis, James E Flege, Clara D Martin

Psycholinguistic research has become increasingly reliant on online experimentation, making it an attractive approach for studying speech production. However, concerns remain about data quality and participant engagement in online settings. In this preregistered study, we used two tasks-picture naming and reading aloud-to test whether the lexical frequency effect (low-frequency words having shorter speech onset times than high-frequency words) could be reliably detected in the online environment (run at home), both with and without experimenter supervision. Participants completed the same two tasks at home and in the lab. Half of the participants performed both tasks with supervision and the other half unsupervised. In the naming task, all conditions yielded consistent frequency effects (~27-41 ms), comparable to previous online and lab findings. In the reading aloud task, lexical frequency effect emerged in all conditions except for the home-supervised, where the effect was in the expected direction but nonsignificant (~12 ms). Notably, participants were overall faster at home than in the lab (~10 ms), and unsupervised settings yielded the largest effect sizes. This suggests that experimenter presence may inadvertently dampen subtle effects, possibly due to increased self-monitoring or reduced comfort. Such findings indicate the reliability of online platforms for speech production research in psycholinguistics and highlight the nuanced influence of supervision on speech outcomes.

心理语言学研究越来越依赖于在线实验,这使得它成为研究语音产生的一种有吸引力的方法。然而,对数据质量和在线环境中参与者参与度的担忧仍然存在。在这项预先注册的研究中,我们使用了两个任务-图片命名和大声朗读-来测试在有和没有实验者监督的在线环境(在家运行)中是否可以可靠地检测到词汇频率效应(低频词比高频词的语音开始时间短)。参与者在家里和实验室里完成了同样的两项任务。一半的参与者在监督下完成了两项任务,另一半则没有监督。在命名任务中,所有条件都产生了一致的频率效应(~27-41 ms),与之前的在线和实验室研究结果相当。在朗读任务中,除家庭监督外,词汇频率效应在所有条件下都出现,其影响方向与预期一致,但不显著(~12 ms)。值得注意的是,参与者在家里的反应速度总体上比在实验室快(约10毫秒),而无监督的环境产生了最大的效应。这表明实验者的存在可能会无意中抑制微妙的影响,可能是由于自我监控的增加或舒适度的降低。这些发现表明了在线平台在心理语言学中语音产生研究的可靠性,并突出了监督对语音结果的微妙影响。
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引用次数: 0
Comparing aperiodic activity in consumer-grade and research-grade EEG: Reliability and association with mathematical ability. 比较消费级和研究级脑电图的非周期性活动:可靠性和与数学能力的关联。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-06 DOI: 10.3758/s13428-025-02905-x
Nienke E R van Bueren, Anne H van Hoogmoed, Sanne H G van der Ven, Lisa M Jonkman

Electroencephalography (EEG) provides valuable insights into brain development, but collecting high-quality data can be tedious, limiting its usability with children. This study evaluates the feasibility and reliability of EEG data acquisition in children with a wireless consumer-grade EEG headset (EMOTIV EPOC X), by comparing it to a research-grade system (BioSemi ActiveTwo), with a focus on aperiodic brain activity. The portability of the EMOTIV headset allows for EEG data collection in ecologically valid, real-world settings such as schools, enabling novel insights into brain activity during learning. We recorded EEG from 93 children (aged 9-10 years) using the EMOTIV headset, beginning with a 4-min resting-state measurement, followed by assessments of mathematical ability, visuospatial working memory, and verbal working memory, in a classroom environment. Aperiodic activity, thought to reflect fundamental aspects of neural excitability and cognitive processing, was extracted and its reliability compared across the two EEG systems. We further tested whether aperiodic activity recorded with EMOTIV predicts mathematical ability, replicating earlier research using research-grade EEG equipment. Our findings reveal that, similar to earlier findings, lower aperiodic activity was associated with higher math performance, supporting its role as a neural marker of cognitive ability. These results demonstrate the feasibility and reliability of using a consumer-grade mobile EEG headset to investigate individual differences in cognitive development in naturalistic contexts. This work opens up new opportunities for large-scale, school-based neurocognitive assessments and paves the way for personalized educational approaches based on neural profiles.

脑电图(EEG)为大脑发育提供了有价值的见解,但收集高质量的数据可能很繁琐,限制了它在儿童中的可用性。本研究通过与研究级系统(BioSemi ActiveTwo)进行比较,评估了使用无线消费级脑电图耳机(EMOTIV EPOC X)采集儿童脑电图数据的可行性和可靠性,重点关注非周期性脑活动。EMOTIV耳机的便携性允许在生态有效的现实环境(如学校)中收集脑电图数据,从而对学习过程中的大脑活动产生新的见解。我们使用EMOTIV耳机记录了93名儿童(9-10岁)的脑电图,从4分钟的静息状态测量开始,然后在教室环境中评估数学能力、视觉空间工作记忆和语言工作记忆。被认为反映神经兴奋性和认知处理基本方面的非周期性活动被提取出来,并在两个脑电图系统中比较其可靠性。我们进一步测试了EMOTIV记录的非周期性活动是否能预测数学能力,复制了使用研究级脑电图设备的早期研究。我们的研究结果表明,与之前的发现类似,较低的非周期性活动与较高的数学成绩有关,这支持了它作为认知能力的神经标志的作用。这些结果证明了使用消费级移动脑电图耳机来研究自然情境下认知发展的个体差异的可行性和可靠性。这项工作为大规模的、基于学校的神经认知评估开辟了新的机会,并为基于神经概况的个性化教育方法铺平了道路。
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引用次数: 0
PupEyes: An interactive Python library for eye movement data processing. PupEyes:一个用于眼动数据处理的交互式Python库。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-05 DOI: 10.3758/s13428-025-02830-z
Han Zhang, John Jonides

We present PupEyes, an open-source Python package for preprocessing and visualizing pupil size and fixation data. PupEyes supports data collected from EyeLink and Tobii eye-trackers as well as any generic dataset that conforms to minimal formatting standards. Developed with current best practices, PupEyes provides a comprehensive pupil preprocessing pipeline and interactive tools for data exploration and diagnosis. In addition to pupil size data, PupEyes provides interactive tools for visualizing fixation data, drawing areas of interest (AOIs), and computing AOI-based metrics. PupEyes uses the pandas data structure and can work seamlessly with other data analysis packages within the Python ecosystem. Overall, PupEyes (1) ensures that pupil size data are preprocessed in a principled, transparent, and reproducible manner, (2) helps researchers better understand their data through interactive visualizations, and (3) enables flexible extensions for further analysis tailored to specific research goals. To ensure computational reproducibility, we provide detailed, executable tutorials ( https://pupeyes.readthedocs.io/ ) that allow users to reproduce and modify the code examples in a virtual environment.

我们提出PupEyes,一个用于预处理和可视化瞳孔大小和注视数据的开源Python包。PupEyes支持从EyeLink和Tobii眼动仪收集的数据,以及符合最小格式标准的任何通用数据集。根据目前的最佳实践,PupEyes提供了一个全面的瞳孔预处理管道和交互式工具,用于数据探索和诊断。除了瞳孔大小数据,PupEyes还提供交互式工具,用于可视化注视数据、绘制感兴趣区域(aoi)和计算基于aoi的指标。PupEyes使用pandas数据结构,可以与Python生态系统中的其他数据分析包无缝协作。总的来说,PupEyes(1)确保瞳孔大小数据以有原则、透明和可重复的方式进行预处理,(2)通过交互式可视化帮助研究人员更好地理解他们的数据,(3)能够灵活扩展,以针对特定的研究目标进行进一步分析。为了确保计算的再现性,我们提供了详细的、可执行的教程(https://pupeyes.readthedocs.io/),允许用户在虚拟环境中再现和修改代码示例。
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引用次数: 0
Design and analysis of individually randomized multiple baseline factorial trials. 设计和分析单独随机多基线析因试验。
IF 3.9 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL Pub Date : 2026-01-05 DOI: 10.3758/s13428-025-02874-1
Yongdong Ouyang, Maria Laura Avila, Anna Heath

Assessing the effectiveness of behavioral interventions in rare diseases is challenging due to extremely limited sample sizes and ethical challenges with withholding intervention when limited treatment options are available. The multiple baseline design (MBD) is commonly used in behavioral science to assess interventions, while allowing all individuals to receive the intervention. MBD is primarily used to evaluate a single intervention so an alternative strategy is needed when evaluating more than one intervention. In this case, a factorial design may be recommended, but a standard factorial design may not be feasible in rare diseases due to extremely limited sample sizes. To address this challenge, we propose the individually randomized multiple baseline factorial design (MBFD), which requires fewer participants but can attain sufficient statistical power for evaluating at least two interventions and their combinations. Furthermore, by incorporating randomization, we enhance the internal validity of the design. This study describes the design characteristics of a standard MBFD, clarifies estimands, and introduces three statistical models under different assumptions. Through simulations, we analyze data from MBFD using linear mixed effect models (LMM) and generalized estimating equations (GEE) to compare biases, sizes, and power of detecting the main effects from the models. We recommend using GEE to mitigate potential random effect misspecifications and suggest small sample corrections, such as Mancl and DeRouen variance estimator, for sample sizes below 120.

评估罕见病行为干预措施的有效性具有挑战性,因为样本量极其有限,而且在治疗选择有限的情况下不进行干预存在伦理挑战。多基线设计(MBD)在行为科学中通常用于评估干预措施,同时允许所有个体接受干预。MBD主要用于评估单一干预措施,因此在评估多个干预措施时需要另一种策略。在这种情况下,可能建议采用析因设计,但由于样本量极其有限,标准析因设计在罕见病中可能不可行。为了解决这一挑战,我们提出了单独随机的多基线因子设计(MBFD),它需要较少的参与者,但可以获得足够的统计能力来评估至少两种干预措施及其组合。此外,通过纳入随机化,我们增强了设计的内部有效性。本研究描述了标准MBFD的设计特点,明确了估计,并介绍了不同假设下的三种统计模型。通过仿真,我们使用线性混合效应模型(LMM)和广义估计方程(GEE)来分析MBFD的数据,以比较模型中检测主要效应的偏差、大小和能力。我们建议使用GEE来减轻潜在的随机效应错误规范,并建议对样本量低于120的样本进行小样本校正,例如Mancl和DeRouen方差估计。
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引用次数: 0
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Behavior Research Methods
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