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Cholera, Iron and Mental Illness in Nineteenth-Century Saint John, NB 19世纪的霍乱、铁与精神疾病
Pub Date : 2017-04-25 DOI: 10.4172/2155-6180.1000341
Paul Te Cusacki
Saint John has a very high rate of Sz in its mainly Irish population. In this paper I examine the possible cause of iron from cast iron piping along with iron in the diet that lead to a weakened immune system and consequent contagious disease such as Cholera. Cholera may do damage to the DNA of fertile women who pass it on to their offspring.
圣约翰以爱尔兰人为主的人口中有很高的Sz比率。在这篇论文中,我研究了铸铁管道中的铁以及饮食中的铁可能导致免疫系统减弱和霍乱等传染病的原因。霍乱可能会破坏能生育的女性的DNA,并将其传给后代。
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引用次数: 3
More on the Robust Solution for Epidemiology: Nineteenth-CenturyQuebec 更多关于流行病学的有力解决方案:19世纪的魁北克
Pub Date : 2017-04-25 DOI: 10.4172/2155-6180.1000342
Paul Te Cusacki
Here we consider the Robust Solution as applied to the cholera epidemic in Lower Canada (Quebec) in 1832. We find that the mathematics from that procedure provides the mathematical foundation or the study. The rate of growth of the virus must be kept below 14% to terminate the spread of the disease.
在这里,我们考虑稳健解决方案适用于1832年下加拿大(魁北克)的霍乱疫情。我们发现这一过程中的数学为研究提供了数学基础。病毒的生长速度必须保持在14%以下,以终止疾病的传播。
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引用次数: 2
Comparisons of Modeling Approaches for Evaluating the LongitudinalAssociation in a Clustered Healthcare Intervention Study 集群医疗干预研究中评估纵向关联的建模方法的比较
Pub Date : 2017-04-25 DOI: 10.4172/2155-6180.1000340
Yulan Liang
This paper addresses methodology issues related to evidence-based healthcare research, specifically when evaluating and analyzing the hospital practice environments (HPE) impacts on the patient health outcomes are conducted in longitudinal intervention survey studies. HPE include the spatially clustered hospital characteristics, including practice environment scale (PES) measures, hospital facilities, nursing staffing and nursing attributes. The longitudinal associations between HPE and patient smoking cessation counseling (SCC) activities, and patient heart failure (HF) outcomes are examined. Various longitudinal and hierarchical modeling are compared including linear mixed models with restricted maximum likelihood estimation, generalized estimating equations with quasi-likelihood estimation, hierarchical linear regression models with nonparametric generalized least squares estimations, and repeated ANOVA. Moreover, both pre-modeling including the items/dimension reduction issues for longitudinal item-response hospital survey data and post-modeling (the mediation analysis) are discussed and conducted. Results show some methodology and solution differences when including the spatial or temporal correlations of HPE simultaneously for examining the longitudinal effects of HPE on HF core outcome measures adjusted or potentially mediated by SCC and nurse staffing environmental variables. This may have implications and potential impact for healthcare decision-making. Patients can benefit from these research findings.
本文讨论了与循证医疗保健研究相关的方法论问题,特别是在纵向干预调查研究中评估和分析医院实践环境(HPE)对患者健康结果的影响时。HPE包括空间聚集的医院特征,包括实践环境规模(PES)措施、医院设施、护理人员配置和护理属性。研究了HPE与患者戒烟咨询(SCC)活动和患者心力衰竭(HF)结果之间的纵向关联。比较了各种纵向和层次模型,包括具有限制最大似然估计的线性混合模型、具有准似然估计的广义估计方程、具有非参数广义最小二乘估计的层次线性回归模型和重复方差分析。此外,还讨论并进行了包括纵向项目响应医院调查数据的项目/维度缩减问题在内的预建模和后建模(中介分析)。结果显示,在同时包括HPE的空间或时间相关性以检查HPE对HF核心结果测量的纵向影响时,存在一些方法和解决方案差异,这些测量由SCC和护士配置环境变量调整或潜在介导。这可能对医疗保健决策产生影响和潜在影响。患者可以从这些研究结果中受益。
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引用次数: 0
A New Method for Analysis of Biomolecules Using the BSM-SG Atomic Models BSM-SG原子模型分析生物分子的新方法
Pub Date : 2017-04-03 DOI: 10.4172/2155-6180.1000339
S. Sargoytchev
Biomolecules and particularly proteins and DNA exhibit some mysterious features that cannot find satisfactory explanation by quantum mechanical modes of atoms. One of them, known as a Levinthal’s paradox, is the ability to preserve their complex three-dimensional structure in appropriate environments. Another one is that they possess some unknown energy mechanism. The Basic Structures of Matter Supergravitation Unified Theory (BSM-SG) allows uncovering the real physical structures of the elementary particles and their spatial arrangement in atomic nuclei. The resulting physical models of the atoms are characterized by the same interaction energies as the quantum mechanical models, while the structure of the elementary particles influence their spatial arrangement in the nuclei. The resulting atomic models with fully identifiable parameters and angular positions of the quantum orbits permit studying the physical conditions behind the structural and bonding restrictions of the atoms connected in molecules. A new method for a theoretical analysis of biomolecules is proposed. The analysis of a DNA molecule leads to formulation of hypotheses about the energy storage mechanism in DNA and its role in the cell cycle synchronization. This permits shedding a light on the DNA feature known as a C-value paradox. The analysis of a tRNA molecule leads to formulation of a hypothesis about a binary decoding mechanism behind the 20 flavors of the complex aminoacyle-tRNA synthetases - tRNA, known as a paradox.
生物分子,特别是蛋白质和DNA表现出一些神秘的特征,而原子的量子力学模式无法对此做出令人满意的解释。其中之一,被称为莱文塔尔悖论,是在适当的环境中保持其复杂三维结构的能力。另一个原因是它们具有某种未知的能量机制。物质超引力统一理论的基本结构(BSM-SG)允许揭示原子核中基本粒子的真实物理结构及其空间排列。由此产生的原子物理模型的特征是与量子力学模型具有相同的相互作用能量,而基本粒子的结构影响它们在原子核中的空间排列。由此产生的具有完全可识别参数和量子轨道角位置的原子模型允许研究分子中连接的原子的结构和键合限制背后的物理条件。提出了一种新的生物分子理论分析方法。对DNA分子的分析导致了对DNA中能量储存机制及其在细胞周期同步中的作用的假设。这就可以揭示被称为C值悖论的DNA特征。对tRNA分子的分析导致了一个假设,即复杂的氨基酰tRNA合成酶-tRNA的20种风味背后的二元解码机制,这被称为悖论。
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引用次数: 0
On Finding the Upper Confidence Limit for a Binomial Proportion when Zero Successes are Observed 零成功情况下二项比例的置信上限求解
Pub Date : 2017-03-30 DOI: 10.4172/2155-6180.1000338
Courtney E. McCracken, S. Looney
We consider confidence interval estimation for a binomial proportion when the data have already been observed and x, the observed number of successes in a sample of size n, is zero. In this case, the main objective of the investigator is usually to obtain a reasonable upper bound for the true probability of success, i.e., the upper limit of a one-sided confidence interval. In this article, we use observed interval length and p-confidence to evaluate eight methods for finding the upper limit of a confidence interval for a binomial proportion when x is known to be zero. Long-run properties such as expected interval length and coverage probability are not applicable because the sample data have already been observed. We show that many popular approximate methods that are known to have good long-run properties in the general setting perform poorly when x=0 and recommend that the Clopper-Pearson exact method be used instead.
我们考虑二项比例的置信区间估计,当数据已经被观察到,并且在大小为n的样本中观察到的成功数x为零。在这种情况下,研究者的主要目标通常是获得真实成功概率的合理上界,即单侧置信区间的上限。在本文中,我们使用观察到的区间长度和p置信度来评估当x已知为零时寻找二项式比例置信区间上限的八种方法。长期运行的属性,如预期的间隔长度和覆盖概率不适用,因为样本数据已经被观察到。我们表明,当x=0时,许多已知在一般设置中具有良好长期性能的流行近似方法表现不佳,并建议使用Clopper-Pearson精确方法代替。
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引用次数: 11
Comparison of the Hemoglobin Amount between Old and Young Persons in Bosnia and Herzegovina 波斯尼亚和黑塞哥维那老年人和青年人血红蛋白含量的比较
Pub Date : 2017-03-21 DOI: 10.4172/2155-6180.1000337
Senol Dogan, Esra Mermer
Hemoglobin is a unique protein, which is responsible for oxygen and carbon dioxide transportation all the body. The protein location is inside the erythrocytes and the special oval shape makes it easily pass through blood walls to supply oxygen to the tissues and organs. It is supposed that the hemoglobin amount could change depending on the person`s age, gender or nationality. We designed a research to see the molecular differences among Bosnian and Turkish young person`s whose age interval is 18-23 and old person`s age interval is 43-65. Totally 300 person`s, 50 from each Bosnian/ Turkish Female/Male and 50 old male and 50 old female were selected for the research. The students` the hemoglobin amount has been recorded individually and presented in a table. As a result of the measurement, The Turkish females average has the lowest hemoglobin Turkish males average shows the maximum amount of hemoglobin, 12.01 g/dl and 14.65 g/dl respectively. When the female gets older their the hemoglobin amount increase in their blood, 7.3% in Bosnian and 12.2% in Turkish. On the other side, the male blood the hemoglobin amount is almost similar by aging, Bosnian male hemoglobin just increase 0.74%, but in Turkish male 1.3% decrease. The result shows that female the hemoglobin amount is affected by age more than male.
血红蛋白是一种独特的蛋白质,负责全身的氧气和二氧化碳运输。蛋白质位于红细胞内部,特殊的椭圆形使其易于穿过血壁,为组织和器官提供氧气。据推测,血红蛋白的含量可能会随着年龄、性别或国籍的不同而变化。我们设计了一项研究来观察波斯尼亚和土耳其年轻人的分子差异,他们的年龄间隔为18-23岁,而老年人的年龄间隔是43-65岁。共选择300人进行研究,其中波斯尼亚/土耳其女性/男性各50人,男性50人,女性50人。学生们的血红蛋白量已经单独记录下来,并在表格中列出。测量结果显示,土耳其女性平均血红蛋白最低。土耳其男性平均血红蛋白含量最高,分别为12.01g/dl和14.65g/dl。当女性年龄增长时,她们血液中的血红蛋白含量会增加,波斯尼亚人为7.3%,土耳其语为12.2%。另一方面,男性血液中的血红蛋白含量随着年龄的增长几乎相似,波斯尼亚男性血红蛋白仅增加0.74%,而土耳其男性则减少1.3%。结果表明,女性血红蛋白含量受年龄的影响大于男性。
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引用次数: 3
Misconceptions and Perceptions on Breast Cancer Risk in Kilifi SouthSubcounty 基利菲南亚县对乳腺癌风险的误解和认识
Pub Date : 2017-02-24 DOI: 10.4172/2155-6180.1000336
L. Alii
The objective was to find out the misconceptions and perceptions associated with breast cancer in Kilifi south subcounty. A survey was conducted on a random sample of women in Kilifi South with no history of breast cancer. The Survey instrument were questionnaires which included measures of perceptions and misconceptions of breast cancer for themselves and for the average woman, perceptions of risk factors that influenced their risk and the average woman’s risk for breast cancer. Descriptive statistics, chi-square tests and spearman’s correlations were used to analyze the data. A spearman’s correlation coefficient showed that, women’s perceptions on Witchcraft as a cause for cancer were related to Cancer being a curse. The correlation was statistically significant at 5% level of significance, (R=0. 5182, S=4462.4, p=0.0003016). A Pearson’s chi-square test also confirmed this (χ2=47.407, P-value=0.000). This probably explains why the uptake of screening services provided by the government in the health centers across the counties has not been effective.
目的是找出与基利菲南亚县乳腺癌有关的误解和看法。对基利菲南部没有乳腺癌病史的妇女进行了一项随机抽样调查。调查工具是调查表,其中包括测量她们自己和一般妇女对乳腺癌的看法和误解、对影响她们患乳腺癌风险的风险因素的看法以及一般妇女患乳腺癌的风险。采用描述性统计、卡方检验和spearman相关分析数据。矛侠相关系数显示,女性认为巫术是癌症的原因,而癌症是一种诅咒。相关性在5%显著水平上有统计学意义(R=0)。5182, S=4462.4, p=0.0003016)。皮尔逊卡方检验也证实了这一点(χ2=47.407, p值=0.000)。这可能解释了为什么政府在各县的卫生中心提供的筛查服务没有得到有效的利用。
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引用次数: 0
Methods for Analysis of Pre-Post Data in Clinical Research: A Comparison of Five Common Methods. 临床研究前后数据分析的方法:五种常用方法的比较。
Pub Date : 2017-02-24 DOI: 10.4172/2155-6180.1000334
Nathaniel S O'Connell, Lin Dai, Yunyun Jiang, Jaime L Speiser, Ralph Ward, Wei Wei, Rachel Carroll, Mulugeta Gebregziabher

Often repeated measures data are summarized into pre-post-treatment measurements. Various methods exist in the literature for estimating and testing treatment effect, including ANOVA, analysis of covariance (ANCOVA), and linear mixed modeling (LMM). Under the first two methods, outcomes can either be modeled as the post treatment measurement (ANOVA-POST or ANCOVA-POST), or a change score between pre and post measurements (ANOVA-CHANGE, ANCOVA-CHANGE). In LMM, the outcome is modeled as a vector of responses with or without Kenward-Rogers adjustment. We consider five methods common in the literature, and discuss them in terms of supporting simulations and theoretical derivations of variance. Consistent with existing literature, our results demonstrate that each method leads to unbiased treatment effect estimates, and based on precision of estimates, 95% coverage probability, and power, ANCOVA modeling of either change scores or post-treatment score as the outcome, prove to be the most effective. We further demonstrate each method in terms of a real data example to exemplify comparisons in real clinical context.

通常重复测量的数据被总结为预处理后测量。文献中存在多种估计和检验治疗效果的方法,包括方差分析(ANOVA)、协方差分析(ANCOVA)和线性混合模型(LMM)。在前两种方法下,结果既可以建模为治疗后测量(ANOVA-POST或ANCOVA-POST),也可以建模为治疗前后测量之间的变化评分(ANOVA-CHANGE, ANCOVA-CHANGE)。在LMM中,结果被建模为有或没有Kenward-Rogers调整的响应向量。我们考虑了文献中常见的五种方法,并从支持模拟和方差的理论推导方面对它们进行了讨论。与现有文献一致,我们的研究结果表明,每种方法都可以得出无偏的治疗效果估计,并且基于估计的精度、95%的覆盖概率和功率,以改变评分或治疗后评分为结果的ANCOVA模型被证明是最有效的。我们进一步展示了每个方法在一个真实的数据例子,以举例比较在真实的临床环境。
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引用次数: 106
On the Relation between the Comprehension Ability and the NeocortexVerbal Areas 论理解能力与新语言领域的关系
Pub Date : 2017-01-30 DOI: 10.4172/2155-6180.1000331
A. Michaud
General description of the human neocortex verbal areas and exploration of the manner in which the synaptic neurolinguistic structure that develops in these areas after birth establishes our comprehension ability. Description of the manner in which the neurolinguistic subjective model of reality that develops in these areas can be made to evolve towards objective representation.
对人类新皮层言语区域的一般描述,以及对出生后在这些区域发展的突触神经语言结构建立我们理解能力的方式的探索。描述在这些领域发展起来的神经语言学主观现实模型可以朝着客观表征的方向发展的方式。
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引用次数: 1
Relative Biochemical Basis of Susceptibility in Commercial WheatVarieties against Angoumois Grain Moth, Sitotroga cerealella (Olivier) andConstruction of its Life Table 商品小麦品种对安谷蛾、西氏灰蛾敏感性的相对生化基础及其生命表的构建
Pub Date : 2017-01-30 DOI: 10.4172/2155-6180.1000333
M. SafianMurad, Z. Batool
A study was conducted to evaluate the relative biochemical basis of susceptibility of six commercial wheat varieties grown in Khyber Pakhtunkhwa, Pakistan, against angoumois grain moth, Sitotroga cerealella (Olivier) (Lepidoptera: Gelechiidae) and construction of its life table at 28 ± 1°C, 65 ± 5 R.H.% and L:D 16:8 hours under laboratory environment. The results were evaluated on the basis of mean pest S. cerealella emergence, percent damage, and percent weight loss, male and female emerged along susceptibility index, 1000 grains weight, hardness and chemical composition of test wheat materials. Life table parameters of S. cerealella on highly susceptible and least susceptible wheat varieties were compared. On the basis of susceptibility index, variety Sirin (5.002) was recorded least susceptible and variety Pirsbak-2005 (7.832) recorded as highly susceptible. The chemical composition based on protein and carbohydrate contents (11.15%, 72.54%) revealed that the variety Sirin was recorded least susceptible, while variety Pirsabak-2005 (12.68%, 75.00%) was noted as highly susceptible. On the basis of life table, the net reproductive rate (10.9) on variety Pirsabak-2005 was higher than variety Sirin (9.4), and the intrinsic rate of increase was also higher on Pirsabak-2005 (30.7) than Sirin (15.9). With respect to doubling time being index of resistance, this time in Pirsabak-2005 was almost half (0.01 days) of the Sirin (0.02 days), which means that S. cerealella can develop more quickly on Pirsabak-2005 germplasm. In summation, relatively least susceptible wheat variety Sirin can be used to increase the level and diversify the basis of resistance to S. cerealella in the resistance breeding programs.
研究了巴基斯坦开伯尔-普赫图赫瓦地区6个商品小麦品种在实验室环境下28±1°C、65±5 R.H.%和L:D 16:8小时对安哥拉谷蛾(Lepidoptera:Gelechidae)易感性的相对生化基础及其生命表的构建。根据试验小麦材料的平均羽化率、受害率和失重率、雄、雌羽化率以及感病指数、1000粒重、硬度和化学成分对试验结果进行了评价。比较了高感和低感小麦品种蜡状芽孢杆菌的生命表参数。根据感病指数,品种Sirin(5.002)为最不感病品种,品种Pirsbak-2005(7.832)为高度感病品种。基于蛋白质和碳水化合物含量的化学成分(11.15%,72.54%)显示,Sirin品种被记录为最不易感,而Pirsabak-2005品种(12.68%,75.00%)被记录为高度易感。根据寿命表,Pirsabak-2005品种的净繁殖率(10.9)高于Sirin品种(9.4),其内在增长率也高于Sirin(15.9),这意味着蜡状芽孢杆菌在Pirsabak-2005种质上可以更快地发育。总之,在抗性育种计划中,相对不易感的小麦品种Sirin可用于提高对蜡状芽孢杆菌的抗性水平并使其基础多样化。
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引用次数: 2
期刊
Journal of biometrics & biostatistics
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