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Rhesus monkeys with damage to amygdala or orbitofrontal cortex perform well on novelty-based memory tasks. 杏仁核或眶额皮层受损的恒河猴在新奇记忆任务中表现良好。
IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2023-02-01 Epub Date: 2022-09-08 DOI: 10.1037/bne0000525
Joshua L Krasney, Joseph R Manns, Andrew M Kazama, Jocelyne Bachevalier

The amygdala and orbitofrontal cortex (OFC) are interconnected regions that serve as key nodes in brain circuits supporting social and affective behaviors. An important question that has come into focus is whether these regions also play a fundamental role in responding to novelty. One possibility is that these regions are important for discriminating novel from familiar stimuli. An alternative possibility is that these regions contribute to affective responses to stimuli in novelty-based tasks. For example, the amygdala and OFC could contribute to assessing novel stimuli as being threatening or previously selected stimuli as having reward value. The present study tested rhesus macaque monkeys with damage to the amygdala or OFC, along with sham-operated control monkeys, across six variants of novelty-based memory tasks. The results showed that monkeys with damage to the amygdala or OFC performed better overall than control monkeys across the tasks. The results indicated that neither region was essential for discriminating novel from familiar stimuli. Instead, the findings suggested that the improved performance observed in novelty-based tasks following damage to these regions was more likely attributable to influences on affect. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

杏仁核(amygdala)和眶额皮层(orbitofrontal cortex,OFC)是相互关联的区域,是支持社交和情感行为的大脑回路的关键节点。一个备受关注的重要问题是,这些区域是否也在对新奇事物做出反应方面扮演着重要角色。一种可能是,这些区域对于辨别新奇刺激和熟悉刺激非常重要。另一种可能是,这些区域有助于在基于新奇的任务中对刺激做出情感反应。例如,杏仁核和大脑后视丘可能有助于评估新奇刺激是否具有威胁性或先前选择的刺激是否具有奖励价值。本研究对杏仁核或OFC受损的猕猴以及假手术对照组猕猴进行了六种新奇记忆任务的测试。结果表明,杏仁核或脑外叶受损的猴子在这些任务中的总体表现优于对照组猴子。结果表明,这两个区域对于辨别新奇刺激和熟悉刺激都不是至关重要的。相反,研究结果表明,这些区域受损后在新奇任务中表现的提高更可能是由于情感的影响。(PsycInfo Database Record (c) 2023 APA, 版权所有)。
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引用次数: 0
Divergent effects of oral cannabis oil extracts marketed as C. indica or C. sativa on exertion of cognitive effort in rats. 口服大麻油提取物对大鼠认知能力的不同影响。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2023-02-01 DOI: 10.1037/bne0000535
Hannah G Brodie, Brett A Hathaway, Andrew Li, Samantha L Baglot, Sukhbir Kaur, Matthew N Hill, Catharine A Winstanley

The main psychoactive compound within the cannabis plant, Δ9-tetrahydrocannabinol (THC), is thought to drive both the sensation of "high" and the cognitive impairments associated with cannabis consumption. Researchers keen to understand how cannabis impairs cognition have, therefore, studied the behavioral effects of systemic injections of THC in animal models. However, cannabis contains multiple other cannabinoids which may critically modulate the resulting cognitive effects. Users also typically eat or smoke cannabis, leading to concern over the translational validity of pure THC injections. We, therefore, tested whether acute oral administration of two different commercially available cannabis extracts, marketed as C. indica or C. sativa, decreased male Long-Evans rats' willingness to exert greater cognitive effort in order to maximize reward earned, as expected from previous experiments using injected THC. Both oils were matched for THC and cannabidiol content. While both cannabis products slowed response times at higher doses, only C. indica oil at the highest dose administered (10 mg/kg THC) decreased the number of trials on which rats chose to complete high-effort/high-reward trials. Repeated dosing with a medium dose of either cannabinoid product (3 mg/kg THC) did not influence choice. Ex vivo analyses confirmed comparable levels of brain THC after C. indica or C. sativa administration. Although controversial in the field, these results support the suggestion that products marketed as different cannabis cultivars have dissociable cognitive effects that may not resemble pure THC and emphasize the importance of the route of administration in experimental design. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

大麻植物中主要的精神活性化合物Δ9-tetrahydrocannabinol(四氢大麻酚)被认为既会导致“兴奋”的感觉,也会导致与大麻消费相关的认知障碍。因此,渴望了解大麻如何损害认知的研究人员在动物模型中研究了全身注射四氢大麻酚的行为影响。然而,大麻含有多种其他大麻素,可能会严重调节由此产生的认知效果。使用者通常还会食用或吸食大麻,这引发了对纯四氢大麻酚注射转化有效性的担忧。因此,我们测试了急性口服两种不同的市售大麻提取物(以C. indica或C. sativa销售)是否会降低雄性Long-Evans大鼠为获得最大奖励而付出更大认知努力的意愿,正如之前使用注射四氢大麻酚的实验所预期的那样。两种油的四氢大麻酚和大麻二酚含量相匹配。虽然两种大麻产品在高剂量下都减慢了反应时间,但只有最高剂量(10毫克/公斤四氢大麻酚)的印度大麻油减少了大鼠选择完成高努力/高回报试验的次数。重复使用中剂量的大麻素产品(3mg /kg THC)不影响选择。离体分析证实了给药后脑内四氢大麻酚水平相当。尽管在该领域存在争议,但这些结果支持了以下建议:作为不同大麻品种销售的产品具有可分离的认知效应,可能与纯四氢大麻酚不同,并强调了实验设计中给药途径的重要性。(PsycInfo数据库记录(c) 2023 APA,版权所有)。
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引用次数: 0
Choice-confirmation bias and gradual perseveration in human reinforcement learning. 人类强化学习中的选择确认偏差和逐步坚持。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2023-02-01 Epub Date: 2022-11-17 DOI: 10.1037/bne0000541
Stefano Palminteri

Do we preferentially learn from outcomes that confirm our choices? In recent years, we investigated this question in a series of studies implementing increasingly complex behavioral protocols. The learning rates fitted in experiments featuring partial or complete feedback, as well as free and forced choices, were systematically found to be consistent with a choice-confirmation bias. One of the prominent behavioral consequences of the confirmatory learning rate pattern is choice hysteresis: that is, the tendency of repeating previous choices, despite contradictory evidence. However, choice-confirmatory pattern of learning rates may spuriously arise from not taking into consideration an explicit choice (gradual) perseveration term in the model. In the present study, we reanalyze data from four published papers (nine experiments; 363 subjects; 126,192 trials), originally included in the studies demonstrating or criticizing the choice-confirmation bias in human participants. We fitted two models: one featured valence-specific updates (i.e., different learning rates for confirmatory and disconfirmatory outcomes) and one additionally including gradual perseveration. Our analysis confirms that the inclusion of the gradual perseveration process in the model significantly reduces the estimated choice-confirmation bias. However, in all considered experiments, the choice-confirmation bias remains present at the meta-analytical level, and significantly different from zero in most experiments. Our results demonstrate that the choice-confirmation bias resists the inclusion of a gradual perseveration term, thus proving to be a robust feature of human reinforcement learning. We conclude by pointing to additional computational processes that may play an important role in estimating and interpreting the computational biases under scrutiny. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

我们是否优先从确认我们选择的结果中学习?近年来,我们在一系列实施越来越复杂的行为协议的研究中调查了这个问题。系统地发现,以部分或完全反馈以及自由和强迫选择为特征的实验中的学习率与选择确认偏差一致。验证性学习率模式的一个突出行为后果是选择滞后:即,尽管有相互矛盾的证据,但仍有重复先前选择的倾向。然而,学习率的选择确认模式可能是由于在模型中没有考虑明确的选择(渐进)持续术语而产生的。在本研究中,我们重新分析了四篇已发表论文(9个实验;363名受试者;126192项试验)的数据,这些论文最初包括在证明或批评人类参与者的选择确认偏见的研究中。我们拟合了两个模型:一个模型以效价特异性更新为特征(即确认和非确认结果的不同学习率),另一个模型还包括逐渐坚持。我们的分析证实,在模型中加入逐步坚持过程显著降低了估计的选择确认偏差。然而,在所有考虑的实验中,选择确认偏差仍然存在于荟萃分析水平,并且在大多数实验中与零显著不同。我们的研究结果表明,选择确认偏差抵制了逐渐坚持项的加入,因此被证明是人类强化学习的一个强大特征。最后,我们指出了额外的计算过程,这些过程可能在估计和解释仔细审查的计算偏差方面发挥重要作用。(PsycInfo数据库记录(c)2023 APA,保留所有权利)。
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引用次数: 0
Acute gut microbiome changes after traumatic brain injury are associated with chronic deficits in decision-making and impulsivity in male rats. 创伤性脑损伤后急性肠道微生物群变化与雄性大鼠决策和冲动能力的慢性缺陷有关。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2023-02-01 Epub Date: 2022-07-28 DOI: 10.1037/bne0000532
Michelle A Frankot, Christopher M O'Hearn, Alyssa M Blancke, Bryan Rodriguez, Kristen M Pechacek, Jasleen Gandhi, Gangqing Hu, Kris M Martens, Cole Vonder Haar

The mechanisms underlying chronic psychiatric-like impairments after traumatic brain injury (TBI) are currently unknown. The goal of the present study was to assess the role of diet and the gut microbiome in psychiatric symptoms after TBI. Rats were randomly assigned to receive a high-fat diet (HFD) or calorie-matched low-fat diet (LFD). After 2 weeks of free access, rats began training on the rodent gambling task (RGT), a measure of risky decision-making and motor impulsivity. After training, rats received a bilateral frontal TBI or a sham procedure and continued postinjury testing for 10 weeks. Fecal samples were collected before injury and 3-, 30-, and 60 days postinjury to evaluate the gut microbiome. HFD altered the microbiome, but ultimately had low-magnitude effects on behavior and did not modify functional outcomes after TBI. Injury-induced functional deficits were far more robust; TBI substantially decreased optimal choice and increased suboptimal choice and motor impulsivity on the RGT. TBI also affected the microbiome, and a model comparison approach revealed that bacterial diversity measured 3 days postinjury was predictive of chronic psychiatric-like deficits on the RGT. A functional metagenomic analysis identified changes to dopamine and serotonin synthesis pathways as a potential candidate mechanism. Thus, the gut may be a potential acute treatment target for psychiatric symptoms after TBI, as well as a biomarker for injury and deficit severity. However, further research will be needed to confirm and extend these findings. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

创伤性脑损伤(TBI)后出现慢性精神损伤的机制目前尚不清楚。本研究旨在评估饮食和肠道微生物组在创伤性脑损伤后精神症状中的作用。大鼠被随机分配接受高脂饮食(HFD)或热量匹配的低脂饮食(LFD)。经过2周的自由饮食后,大鼠开始接受啮齿动物赌博任务(RGT)的训练,该任务是对风险决策和运动冲动性的一种测量。训练结束后,对大鼠进行双侧额叶创伤性脑损伤或假性脑损伤,并继续进行为期 10 周的伤后测试。在受伤前和受伤后 3 天、30 天和 60 天收集粪便样本,以评估肠道微生物组。HFD改变了微生物组,但最终对行为的影响不大,也没有改变创伤性脑损伤后的功能结果。损伤引起的功能障碍要严重得多;创伤性脑损伤大大降低了最佳选择率,增加了次优选择率和RGT运动冲动性。创伤性脑损伤还影响了微生物组,模型比较法显示,伤后3天测量的细菌多样性可预测RGT上类似精神疾病的慢性缺陷。功能元基因组分析发现,多巴胺和血清素合成途径的变化是一种潜在的候选机制。因此,肠道可能是治疗创伤性脑损伤后精神症状的潜在急性治疗目标,也是损伤和缺损严重程度的生物标志物。然而,还需要进一步的研究来证实和扩展这些发现。(PsycInfo Database Record (c) 2023 APA, 版权所有)。
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引用次数: 0
Cognitive and arginine metabolic correlates of temporal dysfunction in the MIA rat model of schizophrenia risk. 认知和精氨酸代谢与MIA大鼠精神分裂症风险模型的颞功能障碍相关。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2023-02-01 DOI: 10.1037/bne0000540
Ashley R Deane, Yu Jing, Reza Shoorangiz, Ping Liu, Ryan D Ward

As a hallmark characteristic of schizophrenia, abnormal perception of time is thought to arise from cognitive impairment; however, the absence of translational models indexing this pathological relationship creates barriers to understanding the functional and biological bases of timing impairments. Here, we investigate the relationship between timing and cognition using the maternal immune activation (MIA) rat model of schizophrenia. We additionally investigate the role of prefrontal cortex L-arginine metabolism in these processes via high-performance liquid chromatography and liquid chromatography/mass spectrometry. Results revealed that MIA rats exhibit greater underestimation of interval durations (2-8 s); greater underestimation corresponded with declines in sustained attention capacity. Working memory impairments were not found to contribute to timing deficits. These findings represent the first direct identification of a timing-attention relationship within rodents and are discussed with respect to the dopamine hypothesis of temporal pace. We also found that MIA exposure altered aspects of arginine metabolism as observed in schizophrenia, and we present preliminary evidence suggesting that these changes have functional consequences for cognition. These findings support the MIA rat model as a valuable tool for future investigations exploring the biological instantiation of interrelated timing and cognitive deficits in schizophrenia. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

作为精神分裂症的一个标志性特征,异常的时间感知被认为是由认知障碍引起的;然而,缺乏对这种病理关系进行索引的翻译模型为理解时间障碍的功能和生物学基础造成了障碍。在此,我们利用母体免疫激活(MIA)精神分裂症大鼠模型来研究时间与认知之间的关系。此外,我们通过高效液相色谱法和液相色谱/质谱法研究了前额叶皮层l -精氨酸代谢在这些过程中的作用。结果显示,MIA大鼠对间隔时间(2 ~ 8 s)有较大的低估;更严重的低估与持续注意能力的下降相对应。工作记忆障碍并未被发现与时间缺陷有关。这些发现代表了啮齿动物中时间-注意力关系的第一个直接识别,并就多巴胺的时间节奏假说进行了讨论。我们还发现,MIA暴露改变了精神分裂症患者精氨酸代谢的各个方面,我们提出了初步证据,表明这些变化对认知功能有影响。这些发现支持MIA大鼠模型作为未来研究探索精神分裂症相关时间和认知缺陷的生物学实例的有价值的工具。(PsycInfo数据库记录(c) 2023 APA,版权所有)。
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引用次数: 0
Supplemental Material for Effect of Striatal Dopamine on Pavlovian Bias. A Large [18F]-DOPA PET Study 纹状体多巴胺对巴甫洛夫偏向影响的补充材料。一项大型[18F]多巴PET研究
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2023-01-09 DOI: 10.1037/bne0000547.supp
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引用次数: 0
Supplemental Material for The Effects of Time Horizon and Guided Choices on Explore–Exploit Decisions in Rodents 时间范围和引导选择对啮齿动物探索-开发决策的影响补充材料
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2023-01-09 DOI: 10.1037/bne0000549.supp
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引用次数: 1
Lack of robust associations between prepandemic coping strategies and frontolimbic circuitry with depression and anxiety symptoms during the COVID-19 pandemic: A preregistered longitudinal study. 在COVID-19大流行期间,大流行前应对策略与前额叶回路与抑郁和焦虑症状之间缺乏强有力的关联:一项预注册的纵向研究。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-12-01 DOI: 10.1037/bne0000534
Bailey Holt-Gosselin, Emily M Cohodes, Sarah McCauley, Jordan C Foster, Paola Odriozola, Sadie J Zacharek, Sahana Kribakaran, Jason T Haberman, H R Hodges, Dylan G Gee

The COVID-19 pandemic is an ongoing stressor that has resulted in the exacerbation of mental health problems worldwide. However, longitudinal studies that identify preexisting behavioral and neurobiological factors associated with mental health outcomes during the pandemic are lacking. Here, we examined associations between prepandemic coping strategy engagement and frontolimbic circuitry with internalizing symptoms during the pandemic. In 85 adults (71.8% female; age 18-30 years), we assessed prototypically adaptive coping strategies (Connor-Davidson Resilience Scale), resting-state functional magnetic resonance imaging functional connectivity (FC) of frontolimbic circuitry, and depression and anxiety symptoms (Beck Depression Inventory, Screen for Child Anxiety-Related Emotional Disorders-Adult, respectively). We conducted general linear models to test preregistered hypotheses that (1) lower coping engagement prepandemic and (2) weaker frontolimbic FC prepandemic would predict elevated symptoms during the pandemic; and (3) coping would interact with FC to predict symptoms during the pandemic. Depression and anxiety symptoms worsened during the pandemic (ps < .001). Prepandemic adaptive coping engagement and frontolimbic FC were not associated with depression or anxiety symptoms during the pandemic (uncorrected ps > .05). Coping interacted with insula-rostral anterior cingulate cortex (ACC) FC (p = .003, pFDR = .014) and with insula-ventral ACC FC (p < .001, pFDR < .001) to predict depression symptoms, but these findings did not survive FDR correction after removal of outliers. Findings from our preregistered study suggest that specific prepandemic factors, particularly adaptive coping and frontolimbic circuitry, are not robustly associated with emotional responses to the pandemic. Additional studies that identify preexisting neurobehavioral factors implicated in mental health outcomes during global health crises are needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

2019冠状病毒病大流行是一个持续的压力源,导致全球精神卫生问题加剧。然而,缺乏确定大流行期间与心理健康结果相关的先前存在的行为和神经生物学因素的纵向研究。在这里,我们研究了大流行前应对策略参与与大流行期间内化症状的额叶边缘回路之间的关系。85例成人(71.8%为女性;年龄18-30岁),我们评估了原型适应性应对策略(康纳-戴维森弹性量表),静息状态功能磁共振成像功能连通性(FC)额叶边缘电路,抑郁和焦虑症状(贝克抑郁量表,儿童焦虑相关情绪障碍筛查-成人)。我们进行了一般线性模型来检验预先登记的假设,即:(1)大流行前较低的应对参与度和(2)大流行前较弱的额叶皮质区可以预测大流行期间症状的升高;(3)应对将与FC相互作用,以预测大流行期间的症状。大流行期间抑郁和焦虑症状加重(ps < 0.001)。大流行前的适应性应对参与和额叶边缘FC与大流行期间的抑郁或焦虑症状无关(未校正的ps > 0.05)。应对与岛吻侧前扣带皮层(ACC) FC (p = 0.003, pFDR = 0.014)和岛腹侧前扣带皮层FC (p < 0.001, pFDR < 0.001)相互作用,预测抑郁症状,但在去除异常值后,这些发现无法在FDR校正后存活。我们预先登记的研究结果表明,特定的大流行前因素,特别是适应性应对和额叶边缘电路,与对大流行的情绪反应没有密切联系。需要进行进一步的研究,以确定在全球健康危机期间与心理健康结果有关的预先存在的神经行为因素。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 0
Chemogenetic inhibition of corticotropin-releasing factor neurons in the central amygdala alters binge-like ethanol consumption in male mice. 中央杏仁核促肾上腺皮质激素释放因子神经元的化学发生抑制改变了雄性小鼠的狂饮样乙醇消耗。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-12-01 Epub Date: 2022-06-30 DOI: 10.1037/bne0000522
S Alex Marshall, Stacey L Robinson, Suzahn E Ebert, Michel A Companion, Todd E Thiele

Repetitive bouts of binge drinking can lead to neuroplastic events that alter ethanol's pharmacologic effects and perpetuate excessive consumption. The corticotropin-releasing factor (CRF) system is an example of ethanol-induced neuroadaptations that drive excessive ethanol consumption. Our laboratory has previously shown that CRF antagonist, when infused into the central amygdala (CeA), reduces binge-like ethanol consumption. The present study extends this research by assessing the effects of silencing CRF-producing neurons in CeA on binge-like ethanol drinking stemming from "Drinking in the Dark" (DID) procedures. CRF-ires-Cre mice underwent surgery to infuse Gi/o-coupled Designer Receptors Exclusively Activated by Designer Drugs (DREADD) virus or a control virus into either the CeA or basolateral amygdala (BLA). Gi/o-DREADD-induced CRF-neuronal inhibition in the CeA resulted in a 33% decrease in binge-like ethanol consumption. However, no effect on ethanol consumption was seen after DREADD manipulation in the BLA. Moreover, CeA CRF-neuronal inhibition had no effect on sucrose consumption. The effects of silencing CRF neurons in the CeA on ethanol consumption are not secondary to changes in motor function or anxiety-like behaviors as assessed in the open-field test (OFT). Finally, the DREADD construct's functional ability to inhibit CRF-neuronal activity was demonstrated by reduced ethanol-induced c-Fos following DREADD activation. Together, these data suggest that the CRF neurons in the CeA play an important role in binge ethanol consumption and that inhibition of the CRF-signaling pathway remains a viable target for manipulating binge-like ethanol consumption. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

反复的酗酒会导致神经可塑性事件,从而改变乙醇的药理作用,使过量饮酒永续下去。促肾上腺皮质激素释放因子(CRF)系统是乙醇诱导的神经适应驱动过量乙醇消耗的一个例子。我们的实验室之前已经证明,当注入中央杏仁核(CeA)时,CRF拮抗剂可以减少酗酒样的乙醇消耗。本研究通过评估沉默CeA中产生crf的神经元对“在黑暗中饮酒”(DID)过程中产生的酗酒样酒精饮酒的影响,扩展了这一研究。CRF-ires-Cre小鼠接受手术,将设计药物特异性激活的Gi/o偶联设计器受体(DREADD)病毒或对照病毒注入CeA或基底外侧杏仁核(BLA)。Gi/o- dreadd诱导的CeA中crf神经元抑制导致狂饮样乙醇消耗减少33%。然而,在BLA中进行DREADD操作后,对乙醇消耗量没有影响。此外,CeA crf神经元抑制对蔗糖消耗没有影响。在开放场试验(OFT)中评估,沉默CeA中CRF神经元对乙醇消耗的影响并非继发于运动功能或焦虑样行为的改变。最后,在DREADD激活后,通过减少乙醇诱导的c-Fos,证明了DREADD结构抑制crf神经元活性的功能能力。综上所述,这些数据表明,CeA中的CRF神经元在狂饮乙醇消费中起着重要作用,抑制CRF信号通路仍然是操纵狂饮乙醇消费的可行靶点。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 1
Differential effects in young and aged rats' navigational accuracy following instantaneous rotation of environmental cues. 环境线索瞬时旋转对年轻和年老大鼠导航精度的不同影响。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-12-01 DOI: 10.1037/bne0000536
Adam W Lester, Gianna A Jordan, Colton J Blum, Zachary P Philpot, Carol A Barnes

Successful navigation depends critically upon two broad categories of spatial navigation strategies that include allocentric and egocentric reference frames, relying on external or internal spatial information, respectively. As with older adults, aged rats show robust impairments on a number of different spatial navigation tasks. There is some evidence that these navigation impairments are accompanied by a bias toward relying on egocentric over allocentric navigation strategies. To test the degree to which young and aged animals utilize these two navigation approaches, a novel behavioral arena was used in which rats are trained to traverse a circular track and to stop at a learned goal location that is fixed with respect to a panorama of visual cues projected onto the surrounding walls. By instantaneously rotating the cues, allocentric and egocentric reference frames were put in direct and immediate conflict and goal navigation performance was assessed with respect to how accurately young and aged animals were able to utilize the rotated cues. Behavioral data collected from nine young and eight aged animals revealed that both age groups were able to update their navigation performance following cue rotation. Contrary to what was expected, however, aged animals showed more accurate overall goal navigation performance, stronger allocentric strategy use, and more evident changes in behavior in response to cue rotation compared to younger animals. The young rats appeared to mix egocentric and allocentric strategies for ICR task solution. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

成功的导航主要依赖于两大类空间导航策略,分别依赖于外部或内部空间信息,包括非中心和自我中心参考框架。与老年人一样,老年大鼠在许多不同的空间导航任务上表现出明显的损伤。有一些证据表明,这些导航障碍伴随着依赖自我中心而不是非中心导航策略的偏见。为了测试幼龄和老年动物利用这两种导航方法的程度,研究人员使用了一个新的行为竞技场,在这个竞技场中,老鼠被训练穿过一个圆形轨道,并在一个习得的目标位置停下来,这个目标位置与投射到周围墙壁上的视觉线索的全景有关。通过即时旋转线索,将非中心和自我中心的参考框架置于直接和即时冲突中,并评估幼鼠和老年鼠利用旋转线索的准确程度。从9只年幼和8只年老的动物身上收集的行为数据显示,这两个年龄组都能够在线索旋转后更新他们的导航表现。然而,与预期相反,与年轻动物相比,老年动物表现出更准确的总体目标导航性能,更强的异中心策略使用,以及更明显的响应线索旋转的行为变化。年轻大鼠在ICR任务解决中表现出自我中心和非中心混合策略。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 0
期刊
Behavioral neuroscience
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