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Effects of a cue associated with cocaine or food reinforcers on extinction and postextinction return of behavior. 与可卡因或食物强化物相关的线索对灭绝和灭绝后行为恢复的影响。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-08-01 DOI: 10.1037/bne0000519
David S Jacobs, Leah N Hitchcock, Rapheal G Williams, K Matthew Lattal

Studies of instrumental responding often include the delivery of a cue that is coincident with the delivery of the reinforcer. One purpose of this is for the cue to be removed during extinction and then presented later to assess whether responding returns (cue-induced reinstatement). In two experiments, we examined the effects of having a cue associated with reinforcement present or absent during extinction. In Experiment 1, the cue was associated with fixed ratio responding for intravenous cocaine or food pellets in one context (Context A), followed by extinction in another context (Context B), where responding produced the cue in one group but did not produce the cue in the other group. Afterward, contextual renewal was assessed with and without the cue in Context A. During extinction, a cue previously associated with cocaine reinforcement caused an increase in responding initially (an extinction burst) and throughout 16 2-hr extinction sessions, as well as weakened contextual renewal when animals were tested with the cue in Context A. In contrast, there were few detectable effects of the cue on extinction and contextual renewal when food pellets were the reinforcer. In Experiment 2, effects of a cue during extinction of progressive ratio responding were revealed with food pellets when animals showed weakened responding on the initial trials of postextinction reacquisition sessions. These experiments demonstrate that the presence of a cue associated with reinforcement during extinction may prolong responding in the short term while creating a more persistent form of extinction that resists relapse. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

工具性反应的研究通常包括提示的传递与强化物的传递是一致的。这样做的一个目的是在消失过程中删除提示,然后稍后呈现以评估是否有响应返回(提示诱导恢复)。在两个实验中,我们检查了在消失过程中存在或不存在与强化相关的线索的影响。在实验1中,线索在一个情境(情境A)中与静脉注射可卡因或食物颗粒的固定比例反应相关,随后在另一个情境(情境B)中消失,其中一组的反应产生线索,而另一组不产生线索。在灭绝期间,先前与可卡因强化相关的线索在最初(灭绝爆发)和16个2小时的灭绝过程中引起了反应的增加,并且当动物在背景a中使用线索进行测试时,背景更新被削弱。相比之下,当食物颗粒作为强化物时,线索对灭绝和背景更新的影响几乎没有可检测到的。在实验2中,当动物在灭绝后再习得的初始试验中表现出较弱的反应时,食物颗粒提示对递进比反应消失的影响。这些实验表明,在消退过程中与强化相关的线索的存在可能会在短期内延长反应,同时创造一种更持久的消退形式,以抵抗复发。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 2
Hormonal contraceptives alter amphetamine place preference and responsivity in the intact female rat. 激素避孕药改变安非他明在完整雌性大鼠的位置偏好和反应性。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-08-01 DOI: 10.1037/bne0000520
Emily N Hilz, Marcelle E Olvera, Dohyun Jun, Megha Chadha, Ross Gillette, Marie-H Monfils, Andrea C Gore, Hongjoo J Lee

Hormonal contraceptives (HCs) containing synthetic ovarian hormones are commonly used among reproductive aged women; HCs alter the physiological state of the user by interfering with endogenous hormone concentrations and their actions on the reproductive tract. As ovarian hormones modulate the incidence of substance abuse disorders in women, this experiment explores how modulating female rat ovarian hormonal states with an HC containing the synthetic progestin levonorgestrel influences measures of drug preference and responsivity. First, rats underwent food-light Pavlovian conditioning to measure conditioned orienting, a known predictor of amphetamine (AMP) place preference. Then, rats were conditioned and tested for AMP place preference with either an HC implant or during estrous cycle stages associated with opposing ovarian hormone levels, that is, proestrus (P) or metestrus/diestrus (M/D), while recording ultrasonic vocalizations (USVs) as an index of he donic drug responsivity. Because of dopamine's (DA's) role in reward learning and memory, DA cell number and activity were examined using tyrosine hydroxylase and FOS immunohistochemistry after a final AMP challenge. Conditioned orienting did not differ between cycling and HC-implanted rats. HC rats emitted fewer USVs in response to AMP, showed marginally less AMP place preference, and had lower DA cell activity in the substantia nigra after AMP compared to P rats. M/D rats showed a similar behavioral profile and neural response as HC rats. This experiment suggests ovarian hormones affect drug preference and responsivity, while providing novel insight into how hormone-altering contraceptives may reduce these measures. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

含有合成卵巢激素的激素避孕药(HCs)通常用于育龄妇女;HCs通过干扰内源性激素浓度及其对生殖道的作用来改变使用者的生理状态。由于卵巢激素调节女性药物滥用障碍的发生率,本实验探讨了含有合成孕激素左炔诺孕酮的HC如何调节雌性大鼠卵巢激素状态影响药物偏好和反应性的测量。首先,大鼠接受了食物轻的巴甫洛夫条件反射来测量条件定向,这是一种已知的安非他明(AMP)位置偏好的预测因子。然后,用HC植入大鼠或在与卵巢激素水平相反的发情周期阶段(即发情前期(P)或初潮/初潮(M/D))对大鼠进行AMP位置偏好的条件反射和测试,同时记录超声发声(USVs)作为药物反应性的指标。由于多巴胺(DA)在奖励学习和记忆中的作用,在最后一次AMP刺激后,使用酪氨酸羟化酶和FOS免疫组织化学检测DA细胞的数量和活性。条件定向在循环大鼠和hc植入大鼠之间没有差异。与P大鼠相比,HC大鼠对AMP的反应释放出更少的usv, AMP的位置偏好略低,AMP后黑质DA细胞活性较低。M/D大鼠表现出与HC大鼠相似的行为特征和神经反应。该实验表明卵巢激素影响药物偏好和反应性,同时为改变激素的避孕药如何减少这些措施提供了新的见解。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 1
Surprise-induced enhancements in the associability of Pavlovian cues facilitate learning across behavior systems. 惊喜引起的巴甫洛夫线索联想性的增强促进了跨行为系统的学习。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-08-01 DOI: 10.1037/bne0000505
Inmaculada Márquez, Gabriel Loewinger, Juan Pedro Vargas, Juan Carlos López, Estrella Díaz, Guillem R Esber

Surprising violations of outcome expectancies have long been known to enhance the associability of Pavlovian cues; that is, the rate at which the cue enters into further associations. The adaptive value of such enhancements resides in promoting new learning in the face of uncertainty. However, it is unclear whether associability enhancements reflect increased associative plasticity within a particular behavior system, or whether they can facilitate learning between a cue and any arbitrary outcome, as suggested by attentional models of conditioning. Here, we show evidence consistent with the latter hypothesis. Violating the outcome expectancies generated by a cue in an appetitive setting (feeding behavior system) facilitated subsequent learning about the cue in an aversive setting (defense behavior system). In addition to shedding light on the nature of associability enhancements, our findings offer the neuroscientist a behavioral tool to dissociate their neural substrates from those of other, behavior system- or valence-specific changes. Moreover, our results present an opportunity to utilize associability enhancements to the advantage of counterconditioning procedures in therapeutic contexts. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

人们早就知道出人意料地违反结果预期会增强巴甫洛夫线索的联想性;也就是说,线索进入进一步联想的速度。这种增强的适应价值在于在面对不确定性时促进新的学习。然而,目前尚不清楚联想性增强是否反映了特定行为系统中联想可塑性的增加,或者它们是否可以促进线索和任意结果之间的学习,正如条件作用的注意模型所表明的那样。在这里,我们展示了与后一种假设一致的证据。违反食欲环境(进食行为系统)中线索产生的结果预期,促进了随后在厌恶环境(防御行为系统)中对线索的学习。除了揭示联想性增强的本质,我们的发现还为神经科学家提供了一种行为工具,将他们的神经基质与其他行为系统或价特异性变化的神经基质分离开来。此外,我们的结果提供了一个机会,利用联想性增强的优势,在治疗背景下对抗条件作用程序。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 0
Time to contrast models of timing: The structure of temporal memory. 时间与时间模型的对比:时间记忆的结构。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-06-02 DOI: 10.1037/bne0000521
A. Machado, Marilia Pinheiro de Carvalho, Marco Vasconcelos
In the study of animal timing over the last 100 years, we identify three different periods, each characterized by a distinct activity. In the first period, researchers brought timing into the laboratory and explored its multiple expressions empirically. In the second period, the growing body of empirical findings inspired researchers to develop a plethora of timing models that vary in theoretical orientation, scope, depth, and quantitative explicitness. We argue that it is now the time to advance towards a third period, wherein researchers select models by comparing them with one another and with data. We make our case by contrasting how the scalar expectancy theory and the learning-to-time model conceive of temporal memory and learning both in concurrent timing tasks and in retrospective timing tasks. We identify four problems related to the structure of temporal memory and to the rules of temporal learning that challenge these models and that should drive the next steps in modeling the timing abilities of animals. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
在对过去100年动物时间的研究中,我们确定了三个不同的时期,每个时期都有一个不同的活动特征。第一个阶段,研究者将时间引入实验室,并从实证角度探索其多重表现形式。在第二个时期,越来越多的实证研究结果激发了研究人员开发了大量的时间模型,这些模型在理论取向、范围、深度和定量清晰度方面各不相同。我们认为,现在是时候向第三个阶段迈进了,在这个阶段,研究人员通过相互比较和与数据比较来选择模型。我们通过对比标量期望理论和学习-时间模型如何理解并发计时任务和回顾性计时任务中的时间记忆和学习来证明我们的观点。我们确定了与时间记忆结构和时间学习规则相关的四个问题,这些问题挑战了这些模型,并且应该推动动物计时能力建模的下一步。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 1
Delayed but not immediate effects of estrogen curtail gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell. 雌激素延迟但不是立即的影响减少-氨基丁酸介导的喂养反应引起的伏隔核壳。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-06-01 DOI: 10.1037/bne0000511
Julio C Diaz, Kate Dunaway, Elizabeth Sheil, Ken Sadeghian, Anthony Auger, Brian A Baldo

The present study investigated immediate versus delayed effects of estrogen replacement in ovariectomized (OVX) rats on hyperphagia elicited by gamma-aminobutyric acid (GABA)-A-agonist (muscimol) infusions into the nucleus accumbens shell (AcbSh). First, because intra-AcbSh muscimol-induced feeding has never been explored in OVX rats, a dose-effect curve was generated and compared to sham-operated males, the current point of reference in the literature. Muscimol (5, 10, 25, and 50 ng) increased food intake in both sexes, and both sexes reached the same asymptotic level of intake. Nevertheless, slopes of the linearized dose-effect functions for males and OVX females differed significantly, with females starting at a lower baseline and exhibiting a steeper slope. Next, the behavioral profiles of a behaviorally active, but nonmaximal intra-AcbSh muscimol dose (25 ng), were examined in a separate group of OVX females at two time-points: immediately after injecting 17β-estradiol 3-benzoate (EB) subcutaneously (5 μg), and 24 hr post-EB. Delayed, but not immediate, EB pretreatment suppressed, but did not eliminate, muscimol-driven food intake. However, EB did not change nonfood-directed behaviors such as locomotion or rearing. These results demonstrate that feeding mediated by intra-AcbSh GABA-A receptors is delimited by delayed, but not rapid, effects of estradiol. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

本研究研究了卵巢切除(OVX)大鼠对γ -氨基丁酸(GABA)- a激动剂(muscimol)输注到伏隔核壳(AcbSh)引起的贪食症的雌激素替代的即时和延迟效应。首先,由于从未在OVX大鼠中探索过acbsh内肌醇诱导的喂养,因此生成了剂量效应曲线,并与假手术的雄性进行了比较,这是目前文献中的参考点。Muscimol(5、10、25和50 ng)增加了两性的食物摄入量,两性的摄入量达到相同的渐近水平。然而,雄性和OVX雌性的线性化剂量效应函数的斜率明显不同,雌性从较低的基线开始,呈现出更陡的斜率。接下来,在另一组OVX雌性小鼠中,在两个时间点(即皮下注射17β-雌二醇- 3-苯甲酸酯(EB)后(5 μg)和注射后24小时),研究了行为活跃但非最大剂量的acbsh muscimol (25 ng)的行为特征。延迟,但不是立即,EB预处理抑制,但没有消除,肌肉驱动的食物摄入。然而,EB并没有改变非食物导向的行为,如运动或饲养。这些结果表明,由acbsh内GABA-A受体介导的摄食被雌二醇的延迟而非快速作用所限制。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 1
Chronic cocaine causes age-dependent increases in risky choice in both males and females. 慢性可卡因导致男性和女性的风险选择随年龄增长而增加。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-06-01 DOI: 10.1037/bne0000509
Shelby L Blaes, Kristy G Shimp, Sara M Betzhold, Barry Setlow, Caitlin A Orsini

Individuals who use cocaine exhibit maladaptive decision-making, overweighting rewards, and underweighting potential risks. We previously showed that chronic cocaine self-administration in young adult male rats causes long-lasting increases in risk taking. The present study expanded upon these findings to determine whether effects of cocaine on risk taking depend on the route of cocaine administration and extend to females. To address the former question, rats in Experiment 1 were trained on the Risky Decision-making Task (RDT), received passively administered cocaine, and were retested in the RDT. Surprisingly, passive cocaine had no effect on risk taking. Experiment 2 determined whether cocaine self-administration increases risk taking in females in a manner comparable to males. Males and females were trained in the RDT, underwent cocaine self-administration, and were retested in the RDT. Unexpectedly, cocaine self-administration had no effect on risk taking in either sex. Because Experiments 1 and 2 involved cocaine exposure at a considerably older age than in previous work, Experiments 3 and 4 determined if cocaine effects on risk taking depend on the age of exposure. Rats began cocaine self-administration at postnatal (PN) day 77 (Experiment 3) or passive cocaine injections starting on PN day 63 (Experiment 4) and were tested in the RDT 3 weeks after cocaine cessation. In these experiments, cocaine increased risk taking in both sexes. These results reveal a limited time window during young adulthood of vulnerability to the effects of chronic cocaine on risk taking. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

使用可卡因的人表现出决策不适应,高估回报,低估潜在风险。我们之前的研究表明,年轻成年雄性大鼠长期自我服用可卡因会导致冒险行为的长期增加。本研究扩大了这些发现,以确定可卡因对风险承担的影响是否取决于可卡因给药途径并延伸到女性。为了解决前一个问题,实验1的大鼠接受了风险决策任务(RDT)的训练,被动给药可卡因,并在RDT中进行了重新测试。令人惊讶的是,被动可卡因对冒险行为没有影响。实验2确定了自我服用可卡因是否会以与男性相当的方式增加女性的风险。男性和女性接受RDT训练,接受可卡因自我给药,并在RDT中重新测试。出乎意料的是,自我服用可卡因对男性和女性的风险承担都没有影响。由于实验1和2涉及的可卡因暴露年龄比之前的研究大得多,实验3和4确定了可卡因对风险承担的影响是否取决于暴露年龄。大鼠在产后第77天(实验3)开始可卡因自我给药,或在产后第63天(实验4)开始被动注射可卡因,并在停止可卡因后3周的RDT中进行测试。在这些实验中,可卡因增加了两性的风险。这些结果揭示了一个有限的时间窗口,在年轻的成年易受慢性可卡因对冒险的影响。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 5
Are observed effects of movement simulated during motor imagery performance? 在运动图像表现过程中,观察到的运动效果是否模拟?
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-06-01 DOI: 10.1037/bne0000517
Jack P. Solomon, A. Hurst, JungWoo Lee, S. Boe
Motor learning relies on adjusting the performance of movements via error detection and correction. How motor learning proceeds via motor imagery, the imagination of movement, is not understood. Motor imagery-based learning is thought to rely on comparing the predicted effect of movement, resulting from the forward model, against its intended effect. Whether motor imagery-based learning uses the observed effect of movement, simulated in motor imagery, to make comparisons to the intended effect to permit error detection and correction, is an open question. To address this, transcranial magnetic stimulation was used to inhibit the left inferior parietal lobe (L_IPL) after each trial of a task requiring participants to reproduce complex trajectories via motor imagery. From past work, we speculated the L_IPL was a candidate for integrating simulated feedback about task performance (simulated observed effects), hypothesizing inhibition of the L_IPL would impair learning, suggesting simulated observed effects of movement are used in motor imagery-based learning. Participants received stimulation to the L_IPL or over the vertex of the head after each trial. Learning was defined as reduced error on a repeated trajectory in comparison to randomly generated trajectories. Regardless of group participants learned, a finding countering our hypothesis, suggesting (a) observed effects of movement are not simulated in motor imagery; (b) the L_IPL is not involved in integrating simulated observed effects of movement; or (c) the timing of the stimulation did not align with the speculated role of the L_IPL. Results encourage further research probing simulated feedback in motor imagery and its neural correlates. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
运动学习依赖于通过错误检测和纠正来调整运动的表现。运动学习是如何通过运动意象,即对运动的想象来进行的,目前还不清楚。基于运动图像的学习被认为依赖于将前向模型产生的运动的预测效果与其预期效果进行比较。基于运动图像的学习是否使用在运动图像中模拟的观察到的运动效果来与预期效果进行比较,以允许错误检测和纠正,这是一个悬而未决的问题。为了解决这一问题,在每次要求参与者通过运动图像再现复杂轨迹的任务试验后,都使用经颅磁刺激来抑制左下顶叶(L_IPL)。根据过去的工作,我们推测L_IPL是整合关于任务表现的模拟反馈(模拟观察效果)的候选者,假设L_IPL的抑制会损害学习,这表明模拟观察到的运动效果用于基于运动图像的学习。每次试验后,参与者接受L_IPL或头顶的刺激。学习被定义为与随机生成的轨迹相比,重复轨迹上的误差减少。无论小组参与者学习了什么,这一发现都与我们的假设相反,表明(a)运动图像中没有模拟观察到的运动效果;(b) L_ IPL不参与整合模拟观察到的运动效果;或(c)刺激的时间与L_ IPL的推测作用不一致。研究结果鼓励进一步研究运动图像中的模拟反馈及其神经相关性。(PsycInfo数据库记录(c)2022 APA,保留所有权利)。
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引用次数: 2
Delay discounting in aging: The influence of cognitive and psychological variables. 衰老中的延迟贴现:认知和心理变量的影响。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-05-23 DOI: 10.1037/bne0000518
I. Macedo, C. Fernandes, F. Barbosa, J. Marques-Teixeira
Delay discounting (or temporal discounting) refers to the decrease of the subjective value of a reward as the time interval for receiving that reward increases. A recent meta-analysis showed that delay discounting appears to be similar across the lifespan as younger, middle-aged, and older adults prefer sooner rewards, despite smaller, over later rewards, even if larger. However further investigation is needed to understand the potential role of individual factors in delay discounting across the lifespan. The present study aimed to contribute to this debate, by investigating the influence of sociodemographic, neurocognitive, and psychological variables on delay discounting. For this purpose, 88 participants (30 younger, 30 middle-aged, and 28 older adults) aged between 19 and 73 years old completed the Monetary Choice Questionnaire (MCQ), a comprehensive battery of neurocognitive tests, and self-report measures of psychopathology. Results revealed no group differences in the rate of discounting. A well-established effect of the amount of the delayed reward was replicated, showing that medium rewards were less discounted than smaller rewards, and larger rewards had lower discounting rates than smaller and medium rewards-the magnitude effect. Regarding the influence of neurocognitive and psychological factors on delay discounting, better working memory, as assessed by the Corsi block-tapping task, significantly predicted larger magnitude effects. The findings of the current work are consistent with the results of previous studies, suggesting that temporal discounting is a stable function across the adult life span. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
延迟折扣(或时间折扣)是指随着获得奖励的时间间隔的增加,奖励的主观价值会降低。最近的一项荟萃分析显示,延迟折扣似乎在整个生命周期中都是相似的,年轻人、中年人和老年人更喜欢更早的奖励(尽管较小),而不是更晚的奖励(即使较大)。然而,需要进一步的研究来了解个体因素在整个生命周期中延迟折扣的潜在作用。本研究旨在通过调查社会人口学、神经认知和心理变量对延迟折扣的影响,为这一争论做出贡献。为此,年龄在19至73岁之间的88名参与者(30名年轻人,30名中年人和28名老年人)完成了货币选择问卷(MCQ),这是一项全面的神经认知测试和精神病理学自我报告测量。结果显示各组在折扣率上没有差异。一个关于延迟奖励数量的既定效应被复制了,显示中等奖励比较小奖励的折扣率更低,而较大奖励的折扣率比较小和中等奖励的折扣率更低——大小效应。在神经认知和心理因素对延迟贴现的影响方面,Corsi块敲击任务评估的较好的工作记忆显著预测了更大的量级效应。目前的研究结果与之前的研究结果一致,表明时间折扣是一个稳定的功能,贯穿成年人的整个生命周期。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 2
Supplemental Material for Delay Discounting in Aging: The Influence of Cognitive and Psychological Variables 衰老延迟折扣的补充材料:认知和心理变量的影响
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-05-05 DOI: 10.1037/bne0000518.supp
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引用次数: 0
Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory. 量化倒U:前额叶多巴胺、D1受体和工作记忆的荟萃分析。
IF 1.9 4区 医学 Q3 BEHAVIORAL SCIENCES Pub Date : 2022-04-07 DOI: 10.1037/bne0000512
Matthew A Weber, Mackenzie M Conlon, Hannah R Stutt, Linder Wendt, Patrick Ten Eyck, Nandakumar S Narayanan
Dopamine in the prefrontal cortex can be disrupted in human disorders that affect cognitive function such as Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), and schizophrenia. Dopamine has a powerful effect on prefrontal circuits via the D1-type dopamine receptor (D1DR). It has been proposed that prefrontal dopamine has "inverted U-shaped" dynamics, with optimal dopamine and D1DR signaling required for peak cognitive function. However, the quantitative relationship between prefrontal dopamine and cognitive function is not clear. Here, we conducted a meta-analysis of published manipulations of prefrontal dopamine and the effects on working memory, a high-level executive function in humans, primates, and rodents that involves maintaining and manipulating information over seconds to minutes. We reviewed 646 articles and found that 75 studies met criteria for inclusion. Our quantification of effect sizes for dopamine, D1DRs, and behavior revealed a negative quadratic slope. This is consistent with the proposed inverted U-shape of prefrontal dopamine and D1DRs and working memory performance, explaining 10% of the variance. Of note, the inverted quadratic fit was much stronger for prefrontal D1DRs alone, explaining 26% of the variance, compared to prefrontal dopamine alone, explaining 10% of the variance. Taken together, these data, derived from a variety of manipulations and systems, demonstrate that optimal prefrontal dopamine signaling is linked with higher cognitive function. Our results provide insight into the fundamental dynamics of prefrontal dopamine, which could be useful for pharmacological interventions targeting prefrontal dopaminergic circuits, and into the pathophysiology of human brain disease. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
前额叶皮层中的多巴胺可能会在影响认知功能的人类疾病中被破坏,比如帕金森病(PD)、注意力缺陷多动障碍(ADHD)和精神分裂症。多巴胺通过d1型多巴胺受体(D1DR)对前额叶回路有强大的影响。有人提出,前额叶多巴胺具有“倒u型”动态,认知功能峰值需要最佳多巴胺和D1DR信号。然而,前额叶多巴胺与认知功能之间的定量关系尚不清楚。在这里,我们对已发表的前额叶多巴胺的操纵及其对工作记忆的影响进行了meta分析。工作记忆是人类、灵长类动物和啮齿动物的一种高级执行功能,涉及在几秒到几分钟内维持和操纵信息。我们回顾了646篇文章,发现75篇研究符合纳入标准。我们对多巴胺、D1DRs和行为的效应量的量化显示为负二次斜率。这与提出的前额叶多巴胺、d1dr和工作记忆表现的倒u形一致,解释了10%的差异。值得注意的是,与单独的前额叶多巴胺相比,前额叶d1dr的倒二次拟合更强,解释了26%的方差,而前额叶多巴胺单独解释了10%的方差。综上所述,这些来自各种操作和系统的数据表明,最佳的前额叶多巴胺信号与更高的认知功能有关。我们的研究结果提供了对前额叶多巴胺基本动态的深入了解,这可能有助于针对前额叶多巴胺能回路的药物干预,以及人类大脑疾病的病理生理学。(PsycInfo Database Record (c) 2022 APA,版权所有)。
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引用次数: 0
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Behavioral neuroscience
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