Pub Date : 2023-10-21DOI: 10.21608/bjas.2023.241783.1267
AbdElAziz El Taweel, Rehab Salem, O. El-Shimi, Fatma Abdalla
Background: Androgenic Up to half of men and females are susceptible to androgenetic alopecia (AGA), a genetically determined condition caused by an overreaction to androgens. The loss of scalp hair in male-pattern baldness is related to androgen metabolism and the hair development cycle, both of which insulin is thought to regulate (Nabaie et al., 2009). We found significant differences in insulin, glucose, and HOMA-IR between the patients and controls when we defined hyperinsulinaemia as a fasting serum insulin level of > 10 U/mL. Androgenic alopecia patients had elevated insulin, glucose, and HOMA-IR compared to healthy individuals. This shows that individuals with androgenic alopecia may have unique metabolic profiles, which points to possible underlying mechanisms in the aetiology and evolution of AGA. Based on our findings, we know that HOMA-IR is positively correlated with insulin levels, and that a higher HOMA-IR is strongly linked to being female.
{"title":"Insulin Resistance in Patients with Androgenic Alpoecia”","authors":"AbdElAziz El Taweel, Rehab Salem, O. El-Shimi, Fatma Abdalla","doi":"10.21608/bjas.2023.241783.1267","DOIUrl":"https://doi.org/10.21608/bjas.2023.241783.1267","url":null,"abstract":"Background: Androgenic Up to half of men and females are susceptible to androgenetic alopecia (AGA), a genetically determined condition caused by an overreaction to androgens. The loss of scalp hair in male-pattern baldness is related to androgen metabolism and the hair development cycle, both of which insulin is thought to regulate (Nabaie et al., 2009). We found significant differences in insulin, glucose, and HOMA-IR between the patients and controls when we defined hyperinsulinaemia as a fasting serum insulin level of > 10 U/mL. Androgenic alopecia patients had elevated insulin, glucose, and HOMA-IR compared to healthy individuals. This shows that individuals with androgenic alopecia may have unique metabolic profiles, which points to possible underlying mechanisms in the aetiology and evolution of AGA. Based on our findings, we know that HOMA-IR is positively correlated with insulin levels, and that a higher HOMA-IR is strongly linked to being female.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.21608/bjas.2023.232964.1239
Emad Esmat, Eslam Tabl, Samir Monib, Ahmed EL DIN
Background: Base Surgery for metacarpal fractures is complicated by the wide variety of treatment options. This research fills a gap in the literature by contrasting the two treatment options for unstable base metacarpal fractures: fixation and temporary arthrodesis. Methods Patients with closed metacarpal fractures who satisfied certain criteria participated in this randomised experiment at a university hospital. Subjects were randomly allocated to either Group A (fixation methods) or Group B. (temporary arthrodesis). Information about the patients' demographics, preoperative evaluations, surgical procedures, and recovery schedules were documented. Subjective and objective ratings, imaging studies, and objective assessments of function all contributed to the final tally. FindingsFifteen participants were included in the research overall. The two groups were similar to one another demographically. Differences emerged between the groups with respect to the length of the operation, the quantity of C-arm pictures, and the time it took to achieve union. Total Active Motion (TAM) and other objective evaluation indicators showed that both groups performed similarly. The occurrence of complications was similar across the two groups. Results from treating unstable base metacarpal fractures with either fixation or temporary arthrodesis were positive, the authors write. The two groups were comparable in terms of demographics, postoperative functional evaluations, and complication rates.roups.
背景：掌骨骨折的基底手术因治疗方案的多样性而变得复杂。本研究通过对比不稳定基底掌骨骨折的两种治疗方案：固定术和临时关节置换术，填补了文献空白。方法 符合特定标准的闭合性掌骨骨折患者参加了在一家大学医院进行的随机实验。受试者被随机分配到 A 组（固定方法）或 B 组（临时关节置换术）。实验记录了患者的人口统计学信息、术前评估、手术过程和恢复时间表。主观和客观评分、影像学检查和对功能的客观评估都有助于得出最终结果。研究结果共有 15 人参与了研究。从人口统计学角度来看，两组参与者的情况相似。两组在手术时间长短、C型臂照片数量以及达到结合所需的时间方面存在差异。总活动度（TAM）和其他客观评价指标显示，两组的表现相似。两组的并发症发生率相似。作者写道，采用固定或临时关节置换术治疗不稳定基底掌骨骨折的结果是积极的。两组在人口统计学、术后功能评估和并发症发生率方面具有可比性。
{"title":"Preliminary Outcomes of Base Metacarpal Fractures Surgical Management","authors":"Emad Esmat, Eslam Tabl, Samir Monib, Ahmed EL DIN","doi":"10.21608/bjas.2023.232964.1239","DOIUrl":"https://doi.org/10.21608/bjas.2023.232964.1239","url":null,"abstract":"Background: Base Surgery for metacarpal fractures is complicated by the wide variety of treatment options. This research fills a gap in the literature by contrasting the two treatment options for unstable base metacarpal fractures: fixation and temporary arthrodesis. Methods Patients with closed metacarpal fractures who satisfied certain criteria participated in this randomised experiment at a university hospital. Subjects were randomly allocated to either Group A (fixation methods) or Group B. (temporary arthrodesis). Information about the patients' demographics, preoperative evaluations, surgical procedures, and recovery schedules were documented. Subjective and objective ratings, imaging studies, and objective assessments of function all contributed to the final tally. FindingsFifteen participants were included in the research overall. The two groups were similar to one another demographically. Differences emerged between the groups with respect to the length of the operation, the quantity of C-arm pictures, and the time it took to achieve union. Total Active Motion (TAM) and other objective evaluation indicators showed that both groups performed similarly. The occurrence of complications was similar across the two groups. Results from treating unstable base metacarpal fractures with either fixation or temporary arthrodesis were positive, the authors write. The two groups were comparable in terms of demographics, postoperative functional evaluations, and complication rates.roups.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.21608/bjas.2023.237325.1255
Ahmed Hamed, Ghada Mohamed, Hend Nasr, Eman Abdulaziz
{"title":"Serum Clusterin Level in with Post Adolescent Acne","authors":"Ahmed Hamed, Ghada Mohamed, Hend Nasr, Eman Abdulaziz","doi":"10.21608/bjas.2023.237325.1255","DOIUrl":"https://doi.org/10.21608/bjas.2023.237325.1255","url":null,"abstract":"","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139330151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.21608/bjas.2023.234076.1241
Ahmed Abdallah, Hesham khaled, Al-Shimaa Mohamed, Basant Mohammad
The Worldwide rates of obesity, particularly among children and young adults, are Increasing. Heart failure, coronary disease, and peripheral vascular disease have all been linked to obesity, and the incidence of their consequences has also been found to fluctuate accordingly. Obese patients often exhibit early signs of heart failure, including subclinical left ventricular dysfunction.The aim of this study was to determine the effect of early age obesity on left and right ventricular functions using echocardiography. 75 healthy volunteers were included in our study who presented to Department of cardiovascular medicine at benha university hospitals in the period between July 2022 to May 2023. All volunteers were evaluated using Echocardiography at Benha University Hospital's Cardiology department and divided into two groups. Group I (control) consisted of participants with a body mass index (BMI) of 25 or less (non-obese), while Group 2 (Case) consisted of participants with a BMI of 30 or more (Obese). Heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) showed no statistically significant differences between the groups. There were no statistically significant variations in PWTd across the groups. Mitral E wave velocity, Mitral A wave velocity, and the E/A ratio showed no statistically significant differences between groups. Obese group had a greater IVSd than the control group.
{"title":"Impact of Early Adulthood Obesity on Left and Right Ventricular Function (An Echocardiographic Study)”","authors":"Ahmed Abdallah, Hesham khaled, Al-Shimaa Mohamed, Basant Mohammad","doi":"10.21608/bjas.2023.234076.1241","DOIUrl":"https://doi.org/10.21608/bjas.2023.234076.1241","url":null,"abstract":"The Worldwide rates of obesity, particularly among children and young adults, are Increasing. Heart failure, coronary disease, and peripheral vascular disease have all been linked to obesity, and the incidence of their consequences has also been found to fluctuate accordingly. Obese patients often exhibit early signs of heart failure, including subclinical left ventricular dysfunction.The aim of this study was to determine the effect of early age obesity on left and right ventricular functions using echocardiography. 75 healthy volunteers were included in our study who presented to Department of cardiovascular medicine at benha university hospitals in the period between July 2022 to May 2023. All volunteers were evaluated using Echocardiography at Benha University Hospital's Cardiology department and divided into two groups. Group I (control) consisted of participants with a body mass index (BMI) of 25 or less (non-obese), while Group 2 (Case) consisted of participants with a BMI of 30 or more (Obese). Heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) showed no statistically significant differences between the groups. There were no statistically significant variations in PWTd across the groups. Mitral E wave velocity, Mitral A wave velocity, and the E/A ratio showed no statistically significant differences between groups. Obese group had a greater IVSd than the control group.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.21608/bjas.2023.233859.1242
rania anwar, Nancy W. Mikhael, Ghada M. Abdel-Khalek, Inas A. Elsayed
Objectives: assessment the concentration of calprotectin in the saliva of patients with oral lichen planus compared to healthy individuals and its relation with severity of the disease . Background: Calprotectin, a calcium-binding protein, is a key player in the pathogenesis of numerous inflammatory diseases, such as psoriasis and acne vulgaris. However, it has not been well studied in patients with oral lichen planus. Data Sources: By searching and reviewing Medline databases (Pub Med and Medscape) and looking for studies that examined the possible role of calprotectin in patients with oral lichen planus available till 2022. Study Selection: We independently reviewed all studies to determine if they met our criteria for inclusion. We included studies that met the following criteria;1.Written and published in English language. 2. Published in peer-reviewed journals.3.Explain how the level of salivary calprotectin may be linked to oral lichen planus and how it may affect severity of the disease . Data Extraction: Studies that did not meet our criteria were excluded from our review. We assessed the quality of the studies based on whether they had ethical approval, specified eligibility criteria, used appropriate controls, and provided adequate information and well-defined evaluation measures. We used a data collection form to independently extract data from each eligible study, focusing on the outcomes that were relevant to our study. Conclusions: Salivary calprotectin level is increased in patients with oral lichen planus compared to healthy control subjects
目的：评估与健康人相比，口腔扁平苔藓患者唾液中钙蛋白的浓度及其与疾病严重程度的关系。背景：钙粘蛋白是一种钙结合蛋白：钙粘蛋白是一种钙结合蛋白，在银屑病和寻常痤疮等多种炎症性疾病的发病机制中起着关键作用。然而，对口腔扁平苔藓患者的研究却不多。数据来源：通过搜索和查阅 Medline 数据库（Pub Med 和 Medscape），寻找 2022 年之前对钙粘蛋白在口腔扁平苔藓患者中可能发挥的作用进行研究的结果。研究筛选：我们对所有研究进行了独立审查，以确定它们是否符合我们的纳入标准。我们纳入了符合以下标准的研究：1.用英语撰写和发表。2.3.解释唾液钙粘蛋白水平如何与口腔扁平苔藓相关联，以及如何影响疾病的严重程度。数据提取：我们将不符合标准的研究排除在综述之外。我们评估研究质量的依据是这些研究是否获得了伦理批准、是否明确规定了资格标准、是否使用了适当的对照组、是否提供了充足的信息和定义明确的评估措施。我们使用数据收集表从每项符合条件的研究中独立提取数据，重点关注与我们的研究相关的结果。研究结论与健康对照组相比，口腔扁平苔藓患者唾液钙蛋白水平升高
{"title":"salivary calprotectin level in patients with oral lichen planus","authors":"rania anwar, Nancy W. Mikhael, Ghada M. Abdel-Khalek, Inas A. Elsayed","doi":"10.21608/bjas.2023.233859.1242","DOIUrl":"https://doi.org/10.21608/bjas.2023.233859.1242","url":null,"abstract":"Objectives: assessment the concentration of calprotectin in the saliva of patients with oral lichen planus compared to healthy individuals and its relation with severity of the disease . Background: Calprotectin, a calcium-binding protein, is a key player in the pathogenesis of numerous inflammatory diseases, such as psoriasis and acne vulgaris. However, it has not been well studied in patients with oral lichen planus. Data Sources: By searching and reviewing Medline databases (Pub Med and Medscape) and looking for studies that examined the possible role of calprotectin in patients with oral lichen planus available till 2022. Study Selection: We independently reviewed all studies to determine if they met our criteria for inclusion. We included studies that met the following criteria;1.Written and published in English language. 2. Published in peer-reviewed journals.3.Explain how the level of salivary calprotectin may be linked to oral lichen planus and how it may affect severity of the disease . Data Extraction: Studies that did not meet our criteria were excluded from our review. We assessed the quality of the studies based on whether they had ethical approval, specified eligibility criteria, used appropriate controls, and provided adequate information and well-defined evaluation measures. We used a data collection form to independently extract data from each eligible study, focusing on the outcomes that were relevant to our study. Conclusions: Salivary calprotectin level is increased in patients with oral lichen planus compared to healthy control subjects","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139331626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.21608/bjas.2023.232705.1238
M. Hegazy, Ahmed R. Zakaria, Mohamed Mounir
Background: Trimalleolar fractures are often referred to as posterior malleolar fractures and have been the subject of continuing interest for a long time as one of the most controversial issues of the treatment of ankle injuries. The aim of this work was to evaluate the effect of posterior malleolus fractures direct reduction and internal fixation on syndesmotic injuries reduction, compared to the direct syndesmotic fixation in trimalleolar ankle fractures, on the functional and short radiological outcomes. Methods: This was a prospective randomized comparative study on the effect of posterior malleolus fractures reduction and internal fixation on syndesmotic injuries reduction, compared to the direct syndesmotic fixation in trimalleolar ankle fractures, on the functional and short radiological outcomes. Patients were divided into two equal groups: Group A: 15 patients with Posterior malleolar fracture left with no direct reduction and internal fixation and group B: 15 patients with posterior malleolar fragment that was fixed directly by screw or plate and screw. 1 case was excluded from group due to open syndesmosis during cotton test intraoperatively during fixing of posterior malleolus, so the patient needed trans syndesmotic screw. Results: Operative duration was significantly lower in group A than group B (p <0.001). Regarding the potential complications of procedures in groups A and B, infection occurred in only 1 (6.67%) patient in group B and didn’t occur in group A, and mechanical irritation occurred in only 1 (6.67%) patient in group A and didn’t occur in
背景：三踝骨折通常被称为后踝骨骨折，作为踝关节损伤治疗中最具争议的问题之一，长期以来一直是人们持续关注的话题。这项研究的目的是评估后踝骨折直接切开复位和韧带损伤切开复位内固定与三踝骨折直接韧带固定相比，对功能和短期放射学结果的影响。方法：这是一项前瞻性随机对比研究，研究对象是后踝骨折复位内固定与三极踝骨折直接韧带内固定相比，对韧带损伤复位的影响，以及对功能和短期影像学结果的影响。患者被平均分为两组：A 组：15 例后踝骨折患者，未进行直接复位和内固定；B 组：15 例后踝骨折患者，直接用螺钉或钢板和螺钉固定。1例患者因术中在固定后臼骨时棉花试验导致巩膜开放而被排除在该组之外，因此该患者需要使用经巩膜螺钉固定。结果A 组的手术时间明显少于 B 组（P <0.001）。关于 A 组和 B 组手术的潜在并发症，B 组仅有 1 例（6.67%）患者发生感染，A 组未发生感染；A 组仅有 1 例（6.67%）患者发生机械刺激，A 组未发生机械刺激。
{"title":"Tri-malleolar Ankle Fractures: Trans-syndesmotic Versus Posterior Malleolar Fixation","authors":"M. Hegazy, Ahmed R. Zakaria, Mohamed Mounir","doi":"10.21608/bjas.2023.232705.1238","DOIUrl":"https://doi.org/10.21608/bjas.2023.232705.1238","url":null,"abstract":"Background: Trimalleolar fractures are often referred to as posterior malleolar fractures and have been the subject of continuing interest for a long time as one of the most controversial issues of the treatment of ankle injuries. The aim of this work was to evaluate the effect of posterior malleolus fractures direct reduction and internal fixation on syndesmotic injuries reduction, compared to the direct syndesmotic fixation in trimalleolar ankle fractures, on the functional and short radiological outcomes. Methods: This was a prospective randomized comparative study on the effect of posterior malleolus fractures reduction and internal fixation on syndesmotic injuries reduction, compared to the direct syndesmotic fixation in trimalleolar ankle fractures, on the functional and short radiological outcomes. Patients were divided into two equal groups: Group A: 15 patients with Posterior malleolar fracture left with no direct reduction and internal fixation and group B: 15 patients with posterior malleolar fragment that was fixed directly by screw or plate and screw. 1 case was excluded from group due to open syndesmosis during cotton test intraoperatively during fixing of posterior malleolus, so the patient needed trans syndesmotic screw. Results: Operative duration was significantly lower in group A than group B (p <0.001). Regarding the potential complications of procedures in groups A and B, infection occurred in only 1 (6.67%) patient in group B and didn’t occur in group A, and mechanical irritation occurred in only 1 (6.67%) patient in group A and didn’t occur in","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139331781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-28DOI: 10.21608/bjas.2023.232642.1237
Adel Adawy, Mohamed Meselhy, Abdallah Eliwa
Background: Genu varum, a common juvenile orthopaedic disease, may cause gait problems and functional difficulties. Hemiepiphysiodesis using an 8-shaped plate is a new technique, although its clinical and radiological results need study. This research examined the clinical and radiological outcomes of hemiepiphysiodesis with 8-shaped plate for juvenile genu varum. Methods: Thirty children aged 3–15 with genu varum were investigated antegrade and retrogradely. The patients had clinical, radiological, and laboratory tests before surgery. Under general anaesthesia, patients were examined for operation time, intraoperative and postoperative problems, radiological follow-up, and hospital stay. Final follow-up was six months following surgery. Results: The research group had a mean age of 6.6 years and 43 percent females and 57 percent men. Correction was done bilaterally (7%), left (10%), and right (13%), targeting femur and tibia (50%) or femur just (10%) or tibia only (40 percent ). Mean hospitalisation was 0.8 days, and average correction was 10.6 months. Surface infections (7%), LIMITED ROM (10%), and damaged screws (3%) were the only difficulties, with 80% with no issues. Rebound correlates with complications. Intercondylar distance, mechanical axis deviation, proximal tibial angle, and distal femoral angle improved significantly. Logistic regression did not find rebound or complications risk variables. Conclusions: 8-plate insertion is a successful therapy for genu varum in children, although rebound and complications must be monitored.ssary.
{"title":"Treatment of pediatric genu varum by temporary hemiepiphysiodesis using 8-shaped plate","authors":"Adel Adawy, Mohamed Meselhy, Abdallah Eliwa","doi":"10.21608/bjas.2023.232642.1237","DOIUrl":"https://doi.org/10.21608/bjas.2023.232642.1237","url":null,"abstract":"Background: Genu varum, a common juvenile orthopaedic disease, may cause gait problems and functional difficulties. Hemiepiphysiodesis using an 8-shaped plate is a new technique, although its clinical and radiological results need study. This research examined the clinical and radiological outcomes of hemiepiphysiodesis with 8-shaped plate for juvenile genu varum. Methods: Thirty children aged 3–15 with genu varum were investigated antegrade and retrogradely. The patients had clinical, radiological, and laboratory tests before surgery. Under general anaesthesia, patients were examined for operation time, intraoperative and postoperative problems, radiological follow-up, and hospital stay. Final follow-up was six months following surgery. Results: The research group had a mean age of 6.6 years and 43 percent females and 57 percent men. Correction was done bilaterally (7%), left (10%), and right (13%), targeting femur and tibia (50%) or femur just (10%) or tibia only (40 percent ). Mean hospitalisation was 0.8 days, and average correction was 10.6 months. Surface infections (7%), LIMITED ROM (10%), and damaged screws (3%) were the only difficulties, with 80% with no issues. Rebound correlates with complications. Intercondylar distance, mechanical axis deviation, proximal tibial angle, and distal femoral angle improved significantly. Logistic regression did not find rebound or complications risk variables. Conclusions: 8-plate insertion is a successful therapy for genu varum in children, although rebound and complications must be monitored.ssary.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-28DOI: 10.21608/bjas.2023.234112.1243
Sherine Ahmed, Ghada Mohamed, Amira Abd El-Ghafar, Hanaa Taha
Background: Acne vulgaris is a prevalent skin disorder characterized by various inflammatory lesions. The pathogenesis of acne involves complex interplays of multiple factors, including increased sebum production, inflammation, and immune responses. Urocortin 3 (UCN 3), a neuropeptide with diverse physiological functions, has been implicated in skin barrier function and immune modulation. However, its role in acne vulgaris remains poorly understood. Objective: This descriptive review aims to provide an overview of UCN 3, explore its known physiological functions, elucidate the pathogenesis of acne vulgaris, and discuss the multifactorial nature of acne development, considering genetic, environmental, and lifestyle factors. Conclusions: The reviewed literature indicates that Urocortin 3 (UCN 3) holds potential implications in acne pathogenesis, as evidenced by its presence in acne-affected skin and altered serum levels in acne patients. Its known physiological functions in stress regulation, inflammation, and immune responses suggest possible roles in acne development and severity. While specific mechanisms remain unclear, exploring UCN 3's interactions with known acne-related pathways may unveil novel therapeutic targets for acne management.
{"title":"Evaluation of Serum Urocortin 3 in acne vulgaris patients","authors":"Sherine Ahmed, Ghada Mohamed, Amira Abd El-Ghafar, Hanaa Taha","doi":"10.21608/bjas.2023.234112.1243","DOIUrl":"https://doi.org/10.21608/bjas.2023.234112.1243","url":null,"abstract":"Background: Acne vulgaris is a prevalent skin disorder characterized by various inflammatory lesions. The pathogenesis of acne involves complex interplays of multiple factors, including increased sebum production, inflammation, and immune responses. Urocortin 3 (UCN 3), a neuropeptide with diverse physiological functions, has been implicated in skin barrier function and immune modulation. However, its role in acne vulgaris remains poorly understood. Objective: This descriptive review aims to provide an overview of UCN 3, explore its known physiological functions, elucidate the pathogenesis of acne vulgaris, and discuss the multifactorial nature of acne development, considering genetic, environmental, and lifestyle factors. Conclusions: The reviewed literature indicates that Urocortin 3 (UCN 3) holds potential implications in acne pathogenesis, as evidenced by its presence in acne-affected skin and altered serum levels in acne patients. Its known physiological functions in stress regulation, inflammation, and immune responses suggest possible roles in acne development and severity. While specific mechanisms remain unclear, exploring UCN 3's interactions with known acne-related pathways may unveil novel therapeutic targets for acne management.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-28DOI: 10.21608/bjas.2023.231186.1234
Ehab Afifi, Amany Fekry, Soaad Abo El-Wafa
Background: Confusion, a One of the most prevalent issues in medicine is a mental and behavioural condition of diminished understanding, coherence, and ability for reason. The acute confusional condition known as delirium continues to be a leading cause of morbidity and death worldwide. There may be neurological predisposing variables when some older persons of the same age have the same procedure and others do not suffer postoperative delirium. Objectives: The purpose of this research was to evaluate the impact of anaesthesia on cognitive function in elderly individuals with femoral neck fracture. Conclusions: Delirium after hip fracture surgery is a frequent but dangerous complication. Metabolic dysfunction, drug-related issues, stress reactions, and anaesthetic type are all possible contributors. Interventions like anxiety reduction and pharmaceutical medications may be useful, but there is no one-size-fits-all approach to prevention.
{"title":"Postoperative confusion after anasthesia in elderly patients with femoral neck fracture","authors":"Ehab Afifi, Amany Fekry, Soaad Abo El-Wafa","doi":"10.21608/bjas.2023.231186.1234","DOIUrl":"https://doi.org/10.21608/bjas.2023.231186.1234","url":null,"abstract":"Background: Confusion, a One of the most prevalent issues in medicine is a mental and behavioural condition of diminished understanding, coherence, and ability for reason. The acute confusional condition known as delirium continues to be a leading cause of morbidity and death worldwide. There may be neurological predisposing variables when some older persons of the same age have the same procedure and others do not suffer postoperative delirium. Objectives: The purpose of this research was to evaluate the impact of anaesthesia on cognitive function in elderly individuals with femoral neck fracture. Conclusions: Delirium after hip fracture surgery is a frequent but dangerous complication. Metabolic dysfunction, drug-related issues, stress reactions, and anaesthetic type are all possible contributors. Interventions like anxiety reduction and pharmaceutical medications may be useful, but there is no one-size-fits-all approach to prevention.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.21608/bjas.2023.234348.1244
Hana Omar, Mohamed Abdelbaki, Houda Rabbany
Background: Neonatal Acute Kidney Injury (AKI) is a critical concern in neonatal intensive care units (NICUs), impacting morbidity and mortality. Early identification of AKI and its risk factors is crucial for improved neonatal care. This study aimed to identify the incidence, predisposing factors, clinical features of AKI in neonates admitted in NICU. Methods: A total of 200 neonates out of 570 cases attending the outpatient clinic were enrolled in the study. Clinical information, maternal medical history, examination findings, laboratory parameters, and medication exposures were collected and analyzed. The KDIGO workgroup definition was adapted to define neonatal AKI. Results : Among neonates, 45.0% developed AKI. Gender and gestational age showed no significant differences between AKI and non-AKI groups. Birth weight below 1000g was associated with AKI (p = 0.03). Neonates with AKI were more likely to receive aminoglycosides and vancomycin (p < 0.001), exhibit oliguric urine output (p < 0.001), and have hypertensive blood pressure levels (p < 0.001). Higher CRP levels (p = 0.002), total leukocyte count (TLC) (p = 0.002), and hemoglobin levels (p = 0.04) were observed in the AKI group. Additionally, sodium and potassium imbalances (p < 0.001) and metabolic acidosis (p < 0.001) were prevalent in AKI cases. Conclusion: This study showed the effect of birth weight, medication exposure, and clinical markers on AKI development. Elevated C-reactive protein levels and blood parameter imbalances serve as important risk indicators
背景：新生儿急性肾损伤（AKI）是新生儿重症监护病房（NICU）的一个重要问题，影响发病率和死亡率。早期识别 AKI 及其风险因素对于改善新生儿护理至关重要。本研究旨在确定新生儿重症监护室收治的新生儿 AKI 的发病率、诱发因素和临床特征。研究方法在门诊就诊的 570 例新生儿中，共有 200 例被纳入研究。收集并分析了临床信息、母亲病史、检查结果、实验室参数和药物接触情况。新生儿 AKI 的定义采用了 KDIGO 工作组的定义。结果：45.0%的新生儿出现了AKI。AKI组和非AKI组的性别和胎龄无明显差异。出生体重低于1000克与AKI有关（p = 0.03）。患有 AKI 的新生儿更有可能使用氨基糖苷类药物和万古霉素（p < 0.001），尿量更少（p < 0.001），血压更高（p < 0.001）。在 AKI 组中观察到较高的 CRP 水平（p = 0.002）、白细胞总数（TLC）（p = 0.002）和血红蛋白水平（p = 0.04）。此外，AKI 病例中普遍存在钠钾失衡（p < 0.001）和代谢性酸中毒（p < 0.001）。结论本研究显示了出生体重、药物接触和临床指标对 AKI 发生的影响。C 反应蛋白水平升高和血液参数失衡是重要的风险指标。
{"title":"Incidence of Early Onset Neonatal Acute Kidney Injury in the NICU of Benha University hospital","authors":"Hana Omar, Mohamed Abdelbaki, Houda Rabbany","doi":"10.21608/bjas.2023.234348.1244","DOIUrl":"https://doi.org/10.21608/bjas.2023.234348.1244","url":null,"abstract":"Background: Neonatal Acute Kidney Injury (AKI) is a critical concern in neonatal intensive care units (NICUs), impacting morbidity and mortality. Early identification of AKI and its risk factors is crucial for improved neonatal care. This study aimed to identify the incidence, predisposing factors, clinical features of AKI in neonates admitted in NICU. Methods: A total of 200 neonates out of 570 cases attending the outpatient clinic were enrolled in the study. Clinical information, maternal medical history, examination findings, laboratory parameters, and medication exposures were collected and analyzed. The KDIGO workgroup definition was adapted to define neonatal AKI. Results : Among neonates, 45.0% developed AKI. Gender and gestational age showed no significant differences between AKI and non-AKI groups. Birth weight below 1000g was associated with AKI (p = 0.03). Neonates with AKI were more likely to receive aminoglycosides and vancomycin (p < 0.001), exhibit oliguric urine output (p < 0.001), and have hypertensive blood pressure levels (p < 0.001). Higher CRP levels (p = 0.002), total leukocyte count (TLC) (p = 0.002), and hemoglobin levels (p = 0.04) were observed in the AKI group. Additionally, sodium and potassium imbalances (p < 0.001) and metabolic acidosis (p < 0.001) were prevalent in AKI cases. Conclusion: This study showed the effect of birth weight, medication exposure, and clinical markers on AKI development. Elevated C-reactive protein levels and blood parameter imbalances serve as important risk indicators","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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