Pub Date : 2023-08-29DOI: 10.21608/bjas.2023.228234.1225
Ehab Abd El-Rahman, Ahmed Elnoury, Abd El-Rahman Fayyad
.
.
{"title":"Evaluation of The Efficacy of Ondansetron in preventing post spinal Anesthesia Hypotension in Cesarean Sections","authors":"Ehab Abd El-Rahman, Ahmed Elnoury, Abd El-Rahman Fayyad","doi":"10.21608/bjas.2023.228234.1225","DOIUrl":"https://doi.org/10.21608/bjas.2023.228234.1225","url":null,"abstract":".","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.21608/bjas.2023.227673.1222
Essam Aql, Omnia Abdallah, G.M .Abdel Khalik, Asmaa Mohammed
Background: Vitiligo is an acquired autoimmune disorder characterized by patchy depigmentation in the skin and hair. Dysregulation of lipid metabolism and immune dysregulation are key factors in the pathogenesis of vitiligo. Apolipoprotein E4 (ApoE4), a protein involved in lipid metabolism, has been implicated in various health conditions. Assessing serum levels of ApoE4 in patients with vitiligo may provide insights into the disease process and clinical implications. Objective: The review aims to explore the potential role of ApoE4 in vitiligo pathogenesis, its association with lipid metabolism and immune dysregulation, and the clinical implications of altered ApoE4 levels. Conclusions: In conclusion, the assessment of serum levels of Apolipoprotein E4 (ApoE4) in patients with vitiligo holds promise as a potential avenue for understanding the disease and its clinical implications.
{"title":"Assessment of Serum level of Apolipoprotein E4 in Patients with Vitiligo: A Comparative Review","authors":"Essam Aql, Omnia Abdallah, G.M .Abdel Khalik, Asmaa Mohammed","doi":"10.21608/bjas.2023.227673.1222","DOIUrl":"https://doi.org/10.21608/bjas.2023.227673.1222","url":null,"abstract":"Background: Vitiligo is an acquired autoimmune disorder characterized by patchy depigmentation in the skin and hair. Dysregulation of lipid metabolism and immune dysregulation are key factors in the pathogenesis of vitiligo. Apolipoprotein E4 (ApoE4), a protein involved in lipid metabolism, has been implicated in various health conditions. Assessing serum levels of ApoE4 in patients with vitiligo may provide insights into the disease process and clinical implications. Objective: The review aims to explore the potential role of ApoE4 in vitiligo pathogenesis, its association with lipid metabolism and immune dysregulation, and the clinical implications of altered ApoE4 levels. Conclusions: In conclusion, the assessment of serum levels of Apolipoprotein E4 (ApoE4) in patients with vitiligo holds promise as a potential avenue for understanding the disease and its clinical implications.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.21608/bjas.2023.224991.1213
A. Bendary, Mohamed Salem, Amr El-Sayed, Haitham Al-Kady, Ayman Khamis, Hany Ebaid
Background: When the TIMI flow is less than 3 or, in the instance of a flow of 3, when the MBG is 0 or 1, no reflow is detected (in the absence of evident vessel dissection, obstruction or distal vessel embolic cutoff). According to the TIMI flow count, the flow in the coronaries may be graded as 0 (no flow), 1 (penetration without perfusion), 2, or 3 (partial perfusion) (complete perfusion). Grade 0 indicates that there is no myocardial blush (or contrast density), while grade 1 indicates that there is continuing blush (staining) Grade 1 indicates the least amount of myocardial blush, grade 2 indicates significant myocardial blush (or contrast density), but less than that seen during angiography of a non-infarct-related coronary artery on the ipsilateral or contralateral side, and grade 3 indicates typical blush. Patients and Methods: This research included 128 individuals who had acute ST elevation myocardial infarction during the first 24 hours of experiencing symptoms and were treated at Wadi El-Nile and Ain Shams university hospitals between the years 2022 and 2023. In order to avoid STEMI patients from having no reflow during PPCI, the research compared the safety and effectiveness of intracoronary injections of epinephrine, verapamil, or adenosine against the control group. Aiming to evaluate TIMI flow grade, MBG, TIMI thrombus grade, ST segment resolution >70%, occurrence of no reflow, EF, LV diameters, and MACE status within 3 months, the study was conducted through 4 groups: group 1 received epinephrine, group 2 received adenosine, group 3 received verapamil, and group 4 did not receive pretreatment. Results: The epinephrine group, followed by the verapamil group, followed by the adenosine group, followed by the control group, had the best TIMI flow grade and MBG scores. After taking the medicines, there was no significant difference in the TIMI thrombus grade across the 4 groups. ST segment resolution varied quantitatively across the 4 groups, but there was no statistically significant difference. The three drugs—Epinephrine, Verapamil, and Adenosine—were all more successful than the control group when it came to preventing no reflow than they were individually. Between the 4 groups, there was no statistically significant difference in the EF and LV diameters. Within a 3-month period, there was no difference in the MACE status across the 4 groups. Conclusion: According to the available data, epinephrine, verapamil, and adenosine are safe and efficient in avoiding no-reflow in patients with ST Elevation Myocardial Infarction during PPCI, with epinephrine performing best, followed by verapamil, then adenosine. To verify these results, more research with a bigger sample size and a longer follow-up period is needed.
{"title":"Intracoronary Pharmacotherapy (Verapamil-Epinephrine-Adenosine) for Prevention of No Reflow during Primary Percutaneous Coronary Intervention in Patients with ST Elevation Myocardial Infarction","authors":"A. Bendary, Mohamed Salem, Amr El-Sayed, Haitham Al-Kady, Ayman Khamis, Hany Ebaid","doi":"10.21608/bjas.2023.224991.1213","DOIUrl":"https://doi.org/10.21608/bjas.2023.224991.1213","url":null,"abstract":"Background: When the TIMI flow is less than 3 or, in the instance of a flow of 3, when the MBG is 0 or 1, no reflow is detected (in the absence of evident vessel dissection, obstruction or distal vessel embolic cutoff). According to the TIMI flow count, the flow in the coronaries may be graded as 0 (no flow), 1 (penetration without perfusion), 2, or 3 (partial perfusion) (complete perfusion). Grade 0 indicates that there is no myocardial blush (or contrast density), while grade 1 indicates that there is continuing blush (staining) Grade 1 indicates the least amount of myocardial blush, grade 2 indicates significant myocardial blush (or contrast density), but less than that seen during angiography of a non-infarct-related coronary artery on the ipsilateral or contralateral side, and grade 3 indicates typical blush. Patients and Methods: This research included 128 individuals who had acute ST elevation myocardial infarction during the first 24 hours of experiencing symptoms and were treated at Wadi El-Nile and Ain Shams university hospitals between the years 2022 and 2023. In order to avoid STEMI patients from having no reflow during PPCI, the research compared the safety and effectiveness of intracoronary injections of epinephrine, verapamil, or adenosine against the control group. Aiming to evaluate TIMI flow grade, MBG, TIMI thrombus grade, ST segment resolution >70%, occurrence of no reflow, EF, LV diameters, and MACE status within 3 months, the study was conducted through 4 groups: group 1 received epinephrine, group 2 received adenosine, group 3 received verapamil, and group 4 did not receive pretreatment. Results: The epinephrine group, followed by the verapamil group, followed by the adenosine group, followed by the control group, had the best TIMI flow grade and MBG scores. After taking the medicines, there was no significant difference in the TIMI thrombus grade across the 4 groups. ST segment resolution varied quantitatively across the 4 groups, but there was no statistically significant difference. The three drugs—Epinephrine, Verapamil, and Adenosine—were all more successful than the control group when it came to preventing no reflow than they were individually. Between the 4 groups, there was no statistically significant difference in the EF and LV diameters. Within a 3-month period, there was no difference in the MACE status across the 4 groups. Conclusion: According to the available data, epinephrine, verapamil, and adenosine are safe and efficient in avoiding no-reflow in patients with ST Elevation Myocardial Infarction during PPCI, with epinephrine performing best, followed by verapamil, then adenosine. To verify these results, more research with a bigger sample size and a longer follow-up period is needed.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.21608/bjas.2023.219408.1199
Sherif Easa El-Sharkawy, Sherif M. El-Sharkawy, Mohsen A. Mashhour, M. Zahed, Abdelsamie M. Halawa, Shareef Al Traigy
Background: Fixed flexion deformity (FFD) is a common manifestation of knee osteoarthritis (OA) that significantly impacts patients' functional abilities and quality of life. Surgical correction of FFD during total knee arthroplasty (TKA) aims to restore joint alignment and improve range of motion. However, a comprehensive understanding of the outcomes and factors influencing the success of this procedure is essential. Objectives: This review article aims to provide a comprehensive overview of the results of surgical correction of FFD during TKA in patients with knee OA. It examines the surgical techniques used, evaluates functional outcomes, pain relief, and range of motion improvements, and assesses the reported rates of complications. Additionally, the durability of the correction and its impact on patient satisfaction and quality of life are explored. Factors influencing long-term success or failure of the procedure are identified. Conclusions: Surgical correction of FFD during TKA has shown promising results in terms of functional improvements, pain relief, and range of motion. Patients experience enhanced functional abilities and improved quality of life following surgery. While complications can occur, meticulous surgical techniques, proper patient selection, and adherence to best practices can help minimize their occurrence. Factors such as surgical technique, patient compliance with rehabilitation, implant selection, and patient-specific characteristics influence the long-term success of the procedure.
背景：固定屈曲畸形（FFD）是膝关节骨性关节炎（OA）的常见表现，严重影响患者的功能能力和生活质量。在全膝关节置换术（TKA）中对固定屈曲畸形进行手术矫正的目的是恢复关节对齐并改善活动范围。然而，全面了解疗效和影响手术成功的因素至关重要。目的：这篇综述文章旨在全面概述膝关节 OA 患者在 TKA 期间进行 FFD 手术矫正的结果。文章探讨了所使用的手术技术，评估了功能效果、疼痛缓解和活动范围的改善，并评估了所报告的并发症发生率。此外，还探讨了矫正的持久性及其对患者满意度和生活质量的影响。还确定了影响手术长期成功或失败的因素。结论：在全膝关节置换术中对 FFD 进行手术矫正在功能改善、疼痛缓解和活动范围方面显示出良好的效果。术后患者的功能得到增强，生活质量得到提高。虽然可能会出现并发症，但细致的手术技术、正确的患者选择和最佳实践的坚持有助于最大限度地减少并发症的发生。手术技巧、患者对康复的依从性、植入物的选择以及患者的具体特征等因素都会影响手术的长期成功。
{"title":"Results of Surgical Correction of Fixed Flexion Deformity during Total Knee Arthroplasty in Patient of Knee Osteoarthritis: A Comprehensive Review","authors":"Sherif Easa El-Sharkawy, Sherif M. El-Sharkawy, Mohsen A. Mashhour, M. Zahed, Abdelsamie M. Halawa, Shareef Al Traigy","doi":"10.21608/bjas.2023.219408.1199","DOIUrl":"https://doi.org/10.21608/bjas.2023.219408.1199","url":null,"abstract":"Background: Fixed flexion deformity (FFD) is a common manifestation of knee osteoarthritis (OA) that significantly impacts patients' functional abilities and quality of life. Surgical correction of FFD during total knee arthroplasty (TKA) aims to restore joint alignment and improve range of motion. However, a comprehensive understanding of the outcomes and factors influencing the success of this procedure is essential. Objectives: This review article aims to provide a comprehensive overview of the results of surgical correction of FFD during TKA in patients with knee OA. It examines the surgical techniques used, evaluates functional outcomes, pain relief, and range of motion improvements, and assesses the reported rates of complications. Additionally, the durability of the correction and its impact on patient satisfaction and quality of life are explored. Factors influencing long-term success or failure of the procedure are identified. Conclusions: Surgical correction of FFD during TKA has shown promising results in terms of functional improvements, pain relief, and range of motion. Patients experience enhanced functional abilities and improved quality of life following surgery. While complications can occur, meticulous surgical techniques, proper patient selection, and adherence to best practices can help minimize their occurrence. Factors such as surgical technique, patient compliance with rehabilitation, implant selection, and patient-specific characteristics influence the long-term success of the procedure.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.21608/bjas.2023.229030.1226
M. El-karamany, Ashraf Bakr, Mostafa Saad, Mohamed Shabanah
The thoracic and lumbar areas account for over 90% of all traumatic spine injuries. The thoracolumbar region, located between the more stiff thoracic and the more flexible lumbar spines, is especially vulnerable to injury.o injury. The purpose of this research was to foresee the long-term effects of these fixations on patients in terms of pain, deformity, motor deficit, and handicap, as well as to identify the functional stability of the vertebral column following fixation. Twenty people participated in our research. Patients had their histories taken, were examined physically and neurologically, and had imaging studies such x-rays and CT scans of the spine and MRIs of the spine performed if needed. What we learn from the research is, Group A had a mean age of 34.8 while Group B had a mean age of 30.10. Males were impacted more severely than females. The thoracolumbar spine is the most often broken in falls from height, followed by car accidents (RTA). Most patients just had thoracolumbar fractures and no other concomitant injuries. On admission, L1 and L3 levels were the most prevalent neurological findings (30%), followed by L2 levels (50%). (25 percent ). Clinically stable thoracolumbar spine fractures often presented with back discomfort at first.. No neurological deficit was reported in group A compared to 30% in group B. The median cobb's angle in group A was 9, ranging from 4 to 18, while in group B, the median cob's angle was 12, ranging from 2 to 35. About 85% of patients had minimal disability during follow up. The long segment and short segment fixation of thoracolumbar burst fractures are both applicable, reproducible techniques of surgical management with similar comparable results regarding postoperative pain rehabilitation, spinal mobility and cobbs angle. But long segment fixation gives more stability specially in multilevel fractures with minimal acceptable sacrifice of spine mobility.
{"title":"Short vs long segment fixation of dorsolumbar burst fracture","authors":"M. El-karamany, Ashraf Bakr, Mostafa Saad, Mohamed Shabanah","doi":"10.21608/bjas.2023.229030.1226","DOIUrl":"https://doi.org/10.21608/bjas.2023.229030.1226","url":null,"abstract":"The thoracic and lumbar areas account for over 90% of all traumatic spine injuries. The thoracolumbar region, located between the more stiff thoracic and the more flexible lumbar spines, is especially vulnerable to injury.o injury. The purpose of this research was to foresee the long-term effects of these fixations on patients in terms of pain, deformity, motor deficit, and handicap, as well as to identify the functional stability of the vertebral column following fixation. Twenty people participated in our research. Patients had their histories taken, were examined physically and neurologically, and had imaging studies such x-rays and CT scans of the spine and MRIs of the spine performed if needed. What we learn from the research is, Group A had a mean age of 34.8 while Group B had a mean age of 30.10. Males were impacted more severely than females. The thoracolumbar spine is the most often broken in falls from height, followed by car accidents (RTA). Most patients just had thoracolumbar fractures and no other concomitant injuries. On admission, L1 and L3 levels were the most prevalent neurological findings (30%), followed by L2 levels (50%). (25 percent ). Clinically stable thoracolumbar spine fractures often presented with back discomfort at first.. No neurological deficit was reported in group A compared to 30% in group B. The median cobb's angle in group A was 9, ranging from 4 to 18, while in group B, the median cob's angle was 12, ranging from 2 to 35. About 85% of patients had minimal disability during follow up. The long segment and short segment fixation of thoracolumbar burst fractures are both applicable, reproducible techniques of surgical management with similar comparable results regarding postoperative pain rehabilitation, spinal mobility and cobbs angle. But long segment fixation gives more stability specially in multilevel fractures with minimal acceptable sacrifice of spine mobility.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-27DOI: 10.21608/bjas.2023.224794.1212
Ahmed Said-Elnaby, Samy Abdelazeem Saad, Tamer Mahmoud Assar, Sara Taha Mostafa
Background: The COVID-19 pandemic has raised concerns about the impact of SARS-CoV-2 infection on pregnant women and their unborn babies. Understanding the clinical characteristics, laboratory findings, and outcomes of COVID-19 in pregnancy is crucial for providing appropriate management and care. This study aimed to describe clinical, laboratory characteristics and maternal and fetal outcomes of third trimesteric pregnant women confirmed to have SARS-CoV-2 infection. Methods: This prospective clinical study included 50 pregnant women aged 20 to 40 years, with gestational age ranging from 28 to 40 weeks. Results: The study population had a mean age of 29.74 years, with a majority being multipara. The most common clinical manifestations were fever (44 %), cough (64%), shortness of breath (32%), ICU admission in (22%) of cases in which (16%) needed mechanical ventilation, and (10%) were shocked. Laboratory findings revealed hematological abnormalities such as leukocytosis (52%), lymphopenia (60%), neutrophilia (52%), and thrombocytopenia (36%). Pregnancy outcome was bad in (8%) of cases with (2%) maternal mortality and (6%) neonatal mortality. As regard neonatal mortality statistics, according to UNICEF, it was 18 deaths per 1,000 live births in 2021(1.8%). As regarded maternal mortality statistics, according to UNICEF, it was 223 deaths per 100,000 live births at 2020 (0.233%). Conclusions: COVID-19 infection during pregnancy has a negative effect on maternal and neonatal outcome regarding both mortality and morbidity concerns.
{"title":"Effect of COVID-19 Infection on Pregnancy","authors":"Ahmed Said-Elnaby, Samy Abdelazeem Saad, Tamer Mahmoud Assar, Sara Taha Mostafa","doi":"10.21608/bjas.2023.224794.1212","DOIUrl":"https://doi.org/10.21608/bjas.2023.224794.1212","url":null,"abstract":"Background: The COVID-19 pandemic has raised concerns about the impact of SARS-CoV-2 infection on pregnant women and their unborn babies. Understanding the clinical characteristics, laboratory findings, and outcomes of COVID-19 in pregnancy is crucial for providing appropriate management and care. This study aimed to describe clinical, laboratory characteristics and maternal and fetal outcomes of third trimesteric pregnant women confirmed to have SARS-CoV-2 infection. Methods: This prospective clinical study included 50 pregnant women aged 20 to 40 years, with gestational age ranging from 28 to 40 weeks. Results: The study population had a mean age of 29.74 years, with a majority being multipara. The most common clinical manifestations were fever (44 %), cough (64%), shortness of breath (32%), ICU admission in (22%) of cases in which (16%) needed mechanical ventilation, and (10%) were shocked. Laboratory findings revealed hematological abnormalities such as leukocytosis (52%), lymphopenia (60%), neutrophilia (52%), and thrombocytopenia (36%). Pregnancy outcome was bad in (8%) of cases with (2%) maternal mortality and (6%) neonatal mortality. As regard neonatal mortality statistics, according to UNICEF, it was 18 deaths per 1,000 live births in 2021(1.8%). As regarded maternal mortality statistics, according to UNICEF, it was 223 deaths per 100,000 live births at 2020 (0.233%). Conclusions: COVID-19 infection during pregnancy has a negative effect on maternal and neonatal outcome regarding both mortality and morbidity concerns.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-27DOI: 10.21608/bjas.2023.229729.1230
Mostafa Mostafa, S. Abdelmaksoud, Osama Kotb
Objectives : to evaluate neonatal transport service in Benha city to assess the outcome of transported newborn and the risk factors of poor outcome. Study Design: prospective observational study. Results: The inter-facility transport of critically ill newborns is an important part of regionalised perinatal care. It enables ill or preterm neonates to receive the best possible care from medical staff with an appropriate level of expertise. The median age on admission was 3 days, ranging from 0.1 to 25 days. The mean gestational age was 35 ±3. Regarding gender, about two-thirds were males (61%). The median birth weight was 2.4 kg, ranging from 1 – 4.6 kg. The most frequent mode of delivery was cesarean section (91%). The median transport duration was 12 minutes, ranging from 5 – 70 minutes. About two-thirds were accompanied by paramedical personnel only. Conclusion Interhospital transport of very low birth weight (VLBW) infants may cause deterioration in their physiologic status, the likelihood of which is increased with longer duration of transport. Better temperature regulation during interhospital transport may decrease the chances of deterioration in physiological status of low birth weight infants.
{"title":"Assessment of The Neonatal Transport Service in Benha","authors":"Mostafa Mostafa, S. Abdelmaksoud, Osama Kotb","doi":"10.21608/bjas.2023.229729.1230","DOIUrl":"https://doi.org/10.21608/bjas.2023.229729.1230","url":null,"abstract":"Objectives : to evaluate neonatal transport service in Benha city to assess the outcome of transported newborn and the risk factors of poor outcome. Study Design: prospective observational study. Results: The inter-facility transport of critically ill newborns is an important part of regionalised perinatal care. It enables ill or preterm neonates to receive the best possible care from medical staff with an appropriate level of expertise. The median age on admission was 3 days, ranging from 0.1 to 25 days. The mean gestational age was 35 ±3. Regarding gender, about two-thirds were males (61%). The median birth weight was 2.4 kg, ranging from 1 – 4.6 kg. The most frequent mode of delivery was cesarean section (91%). The median transport duration was 12 minutes, ranging from 5 – 70 minutes. About two-thirds were accompanied by paramedical personnel only. Conclusion Interhospital transport of very low birth weight (VLBW) infants may cause deterioration in their physiologic status, the likelihood of which is increased with longer duration of transport. Better temperature regulation during interhospital transport may decrease the chances of deterioration in physiological status of low birth weight infants.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-27DOI: 10.21608/bjas.2023.227984.1224
Osama Alkady, Shymaa Rezk, Aya Abd elmonam
Background: Scar development is a typical consequence of skin injuries and surgical procedures, causing functional and aesthetic issues. Current approaches for scar care have limits, necessitating the investigation of alternative therapies. In addition to its well-known function in glucose metabolism, insulin has demonstrated promise as an anti-scar agent due to its effects on wound healing and tissue remodelling. Objectives: The purpose of this review is to investigate the role of Insulin and its mechanisms of action in scar reduction, evaluate the results of clinical trials, and address the problems and future directions of this field. Conclusions: Insulin exerts its anti-scar actions via multiple pathways, such as fibroblast proliferation, extracellular matrix remodelling, and regulation of scar-related gene expression. In vitro and animal research have shown good results, supporting insulin's potential as an efficient scar-reduction treatment. Nevertheless, obstacles pertaining to dosage determination, administration techniques, and potential adverse effects must be solved.
{"title":"Insulin as Anti-Scar Treatment: A Comprehensive Review","authors":"Osama Alkady, Shymaa Rezk, Aya Abd elmonam","doi":"10.21608/bjas.2023.227984.1224","DOIUrl":"https://doi.org/10.21608/bjas.2023.227984.1224","url":null,"abstract":"Background: Scar development is a typical consequence of skin injuries and surgical procedures, causing functional and aesthetic issues. Current approaches for scar care have limits, necessitating the investigation of alternative therapies. In addition to its well-known function in glucose metabolism, insulin has demonstrated promise as an anti-scar agent due to its effects on wound healing and tissue remodelling. Objectives: The purpose of this review is to investigate the role of Insulin and its mechanisms of action in scar reduction, evaluate the results of clinical trials, and address the problems and future directions of this field. Conclusions: Insulin exerts its anti-scar actions via multiple pathways, such as fibroblast proliferation, extracellular matrix remodelling, and regulation of scar-related gene expression. In vitro and animal research have shown good results, supporting insulin's potential as an efficient scar-reduction treatment. Nevertheless, obstacles pertaining to dosage determination, administration techniques, and potential adverse effects must be solved.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.21608/bjas.2023.229085.1227
Mohammed Elashhab, Mamdouh Elkaramany, Hossam Saad
Background: Spinal infections exhibit a wide range of clinical signs. The clinical effects can encompass the vertebral bodies, spinal canal, intervertebral discs, and adjacent paravertebral structures. Surgical treatment becomes necessary when there's a presence of neurological deficits, epidural abscess, or the development of kyphotic deformity. The approach involving anterior debridement and fusion has demonstrated its efficacy in managing pyogenic spondylodiscitis. This method facilitates direct reach to the infected disc, allowing thorough debridement and proper placement of bone graft to ensure adequate stabilization. On the other hand, the posterior approach is more proficient in correcting kyphosis. Aim: The aim of this thesis is to conduct a comprehensive comparison of the clinical, radiological, and functional outcomes between the surgical approaches of anterior and posterior methods in the treatment of spondylodiscitis. Patients and methods: A prospective cohort study was conducted in Benha university hospital including thirty patients with dorsolumber spondylodiscitis were admitted and managed operatively between May 2020 and June 2023. Patients were divided into two groups. Group (A): 15 patients (50%) were operated via anterior approach and group (B): 15 patients (50%) were operated via posterior approach. The diagnosis was confirmed through a combination of clinical presentation, laboratory analyses, and radiological evaluations. The study involved a 12-week follow-up period to assess the progression and outcomes of the condition. Results: The mean age of patients of group A was 52 ±8 and group B was 52 ±7. The most frequent site in group A was lumbar (46.7%), followed by thoracolumbar (40%) and thoracic (13.3%), while in group B, the most frequent was lumbar (40%), followed by thoracic (33.35) and thoracolumbar (26.7%). Functional outcome (regarding Oswestry disability index) was improved from 84% and 82% preoperatively to 28% and 30% postoperatively in Group A and Group B respectively. Regarding Local Kyphotic Angle, group B demonstrated significantly higher correction degrees than the anterior approach group A. Regarding hospital stay in our study, Group B demonstrated significantly higher hospital stay than group A. Also, Posterior group exhibited significantly higher operative time and blood loss. Conclusion: Both the anterior and posterior approaches are effective in accomplishing the objectives of surgical intervention for thoracic and lumbar Spondylodiscitis. However, the posterior approach provides notably superior correction of the kyphotic angle, albeit at the cost of increased operative time, prolonged hospital stay, and greater blood loss.
{"title":"Anterior versus Posterior Approach in Surgical Treatment of Dorsolumber Spondylodiscitis","authors":"Mohammed Elashhab, Mamdouh Elkaramany, Hossam Saad","doi":"10.21608/bjas.2023.229085.1227","DOIUrl":"https://doi.org/10.21608/bjas.2023.229085.1227","url":null,"abstract":"Background: Spinal infections exhibit a wide range of clinical signs. The clinical effects can encompass the vertebral bodies, spinal canal, intervertebral discs, and adjacent paravertebral structures. Surgical treatment becomes necessary when there's a presence of neurological deficits, epidural abscess, or the development of kyphotic deformity. The approach involving anterior debridement and fusion has demonstrated its efficacy in managing pyogenic spondylodiscitis. This method facilitates direct reach to the infected disc, allowing thorough debridement and proper placement of bone graft to ensure adequate stabilization. On the other hand, the posterior approach is more proficient in correcting kyphosis. Aim: The aim of this thesis is to conduct a comprehensive comparison of the clinical, radiological, and functional outcomes between the surgical approaches of anterior and posterior methods in the treatment of spondylodiscitis. Patients and methods: A prospective cohort study was conducted in Benha university hospital including thirty patients with dorsolumber spondylodiscitis were admitted and managed operatively between May 2020 and June 2023. Patients were divided into two groups. Group (A): 15 patients (50%) were operated via anterior approach and group (B): 15 patients (50%) were operated via posterior approach. The diagnosis was confirmed through a combination of clinical presentation, laboratory analyses, and radiological evaluations. The study involved a 12-week follow-up period to assess the progression and outcomes of the condition. Results: The mean age of patients of group A was 52 ±8 and group B was 52 ±7. The most frequent site in group A was lumbar (46.7%), followed by thoracolumbar (40%) and thoracic (13.3%), while in group B, the most frequent was lumbar (40%), followed by thoracic (33.35) and thoracolumbar (26.7%). Functional outcome (regarding Oswestry disability index) was improved from 84% and 82% preoperatively to 28% and 30% postoperatively in Group A and Group B respectively. Regarding Local Kyphotic Angle, group B demonstrated significantly higher correction degrees than the anterior approach group A. Regarding hospital stay in our study, Group B demonstrated significantly higher hospital stay than group A. Also, Posterior group exhibited significantly higher operative time and blood loss. Conclusion: Both the anterior and posterior approaches are effective in accomplishing the objectives of surgical intervention for thoracic and lumbar Spondylodiscitis. However, the posterior approach provides notably superior correction of the kyphotic angle, albeit at the cost of increased operative time, prolonged hospital stay, and greater blood loss.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.21608/bjas.2023.227664.1221
Hamdy Elgazzar, Mohamed El-mohamdy, A. Abdelshafy, Amr Abd- Elkareem Abd-Elattif
Background: Diabetic macular edema (DME) is a leading cause for loss of central vision in diabetics with retinopathy. Treatment approaches for DME have shifted away from Laser therapy as the first line of therapy for DME. Aim and objectives: to investigate the changes in Optical coherence tomography angiography (OCT-A) after suprachoroidal injection of triamcinolone acetonide (SCTA) in patients with diabetic macular edema. Patients and Methods: This a prospective case series study that was conducted on twenty eyes with refractory diabetic macular edema who treated with single suprachoroidal injection of triamcinolone acetonide. All patients underwent history taking, ocular examination and optical coherence tomography angiography (OCT-Angiography). Results: there was no statistically significant difference between the studied groups as regard (Relation between baseline, third month and sixth month LogMAR BCVA), (Relation between baseline, third month and sixth month CFT (Central foveal thickness)), (Relation between baseline, third month, sixth month SVD (superficial vessel density) and sixth month DVD (Deep vessel density)), (Relation between baseline, third month and sixth month FAZ (Foveal avascular zone) in mm) and (Correlation between BCVA at six month and (CFT, SVD, DVD, FAZ) at six months). Conclusion: our findings suggest that SCTA may be an effective treatment option for diabetic macular edema, improving visual outcomes and reducing retinal thickness.
{"title":"Changes in Optical Coherence Tomography Angiography after Suprachoroidal Triamcinolone Acetonide injection in Diabetic patients","authors":"Hamdy Elgazzar, Mohamed El-mohamdy, A. Abdelshafy, Amr Abd- Elkareem Abd-Elattif","doi":"10.21608/bjas.2023.227664.1221","DOIUrl":"https://doi.org/10.21608/bjas.2023.227664.1221","url":null,"abstract":"Background: Diabetic macular edema (DME) is a leading cause for loss of central vision in diabetics with retinopathy. Treatment approaches for DME have shifted away from Laser therapy as the first line of therapy for DME. Aim and objectives: to investigate the changes in Optical coherence tomography angiography (OCT-A) after suprachoroidal injection of triamcinolone acetonide (SCTA) in patients with diabetic macular edema. Patients and Methods: This a prospective case series study that was conducted on twenty eyes with refractory diabetic macular edema who treated with single suprachoroidal injection of triamcinolone acetonide. All patients underwent history taking, ocular examination and optical coherence tomography angiography (OCT-Angiography). Results: there was no statistically significant difference between the studied groups as regard (Relation between baseline, third month and sixth month LogMAR BCVA), (Relation between baseline, third month and sixth month CFT (Central foveal thickness)), (Relation between baseline, third month, sixth month SVD (superficial vessel density) and sixth month DVD (Deep vessel density)), (Relation between baseline, third month and sixth month FAZ (Foveal avascular zone) in mm) and (Correlation between BCVA at six month and (CFT, SVD, DVD, FAZ) at six months). Conclusion: our findings suggest that SCTA may be an effective treatment option for diabetic macular edema, improving visual outcomes and reducing retinal thickness.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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