Background: This study aimed to develop a novel drug formulation using polybutylcyanoacrylate (PBCA) nanoparticles to deliver cisplatin, a commonly used chemotherapeutic agent for breast cancer treatment.Materials and Methods: PBCA nanoparticles were synthesized using a mini-emulsion polymerization method, and the resulting NPs were comprehensively characterized for their physical properties, such as size, size distribution, zeta potential, drug loading, and encapsulation efficiency. In addition, the cytotoxicity of the NPs was assessed, along with their ability to release the entrapped drugs over time. Results: The results showed that the PBCA nanoparticles had a mean size of 457 ± 7.4 nm, a size distribution of 0.253±0.011 and a negative zeta potential of -12.3 ± 1.3 mV. The drug encapsulation efficiency and loading capacity of cisplatin-PBCA were found to be 45.6 ± 2.7% and 3.5 ±0.8%, respectively; The release of the drug from the PBCA was estimated to be approximately 12.2±1.1% after 45 hours. The cytotoxic effects of the nanoparticle formulation were significantly enhanced compared to the free drug. The cytotoxicity of cisplatin-PBCA was evaluated in the T-47D breast cancer cell line, showing promising results as a potential drug formulation for breast cancer therapy. Conclusions: These findings suggest that cisplatin-PBCA may offer advantages over traditional cisplatin formulations, potentially improving the efficacy and reducing the toxicity of breast cancer treatment.
{"title":"Investigating the Properties and Cytotoxicity of Cisplatin-Loaded Nano-Polybutylcyanoacrylate on Breast Cancer Cells","authors":"Amirsasan Gorgzadeh, Ali Hheidari, Parizad Ghanbarikondori, Mahshid Arastonejad, Tayebeh Ghasemi Goki, Mehrad Aria, Ahmadreza Allahyartorkaman, Farimah Moazzam","doi":"10.31557/apjcb.2023.8.4.345-350","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.345-350","url":null,"abstract":"Background: This study aimed to develop a novel drug formulation using polybutylcyanoacrylate (PBCA) nanoparticles to deliver cisplatin, a commonly used chemotherapeutic agent for breast cancer treatment.Materials and Methods: PBCA nanoparticles were synthesized using a mini-emulsion polymerization method, and the resulting NPs were comprehensively characterized for their physical properties, such as size, size distribution, zeta potential, drug loading, and encapsulation efficiency. In addition, the cytotoxicity of the NPs was assessed, along with their ability to release the entrapped drugs over time. Results: The results showed that the PBCA nanoparticles had a mean size of 457 ± 7.4 nm, a size distribution of 0.253±0.011 and a negative zeta potential of -12.3 ± 1.3 mV. The drug encapsulation efficiency and loading capacity of cisplatin-PBCA were found to be 45.6 ± 2.7% and 3.5 ±0.8%, respectively; The release of the drug from the PBCA was estimated to be approximately 12.2±1.1% after 45 hours. The cytotoxic effects of the nanoparticle formulation were significantly enhanced compared to the free drug. The cytotoxicity of cisplatin-PBCA was evaluated in the T-47D breast cancer cell line, showing promising results as a potential drug formulation for breast cancer therapy. Conclusions: These findings suggest that cisplatin-PBCA may offer advantages over traditional cisplatin formulations, potentially improving the efficacy and reducing the toxicity of breast cancer treatment.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139287780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-28DOI: 10.31557/apjcb.2023.8.4.387-393
Haniye Jafari, Mojtaba Esmailpour Roshan
Skin is the most important part of the human body, protecting the muscles, bones and the entire body. One of the most common diseases affecting many people today is cancer, and skin cancer is one of the most common cancers known to man. As one of the deadliest cancers, skin cancer requires special attention. Skin cancer is caused by genetic defects or mutations caused by unreduced deoxyribonucleic acid in skin cells. One of the most dangerous types of skin cancer is melanoma, which has a high survival rate if detected early. Accordingly, early detection of melanoma is very important. To this end, this paper presents a computer-aided method that uses image processing tools to detect skin cancer, especially melanoma. This system takes an image of a skin lesion and uses new image processing techniques to determine the presence of skin cancer. The lesion image analysis tool evaluates various features of melanoma, including asymmetry, contour, color, diameter (ABCD), and more. Then these extracted parameters are used to classify the images as benign or malignant lesions. This article describes methods and approaches for automatic skin cancer detection. This article provides researchers with useful information about the methods, databases, and procedures required for early detection of skin cancer.
{"title":"Review on Automated Skin Cancer Detection Using Image Processing Techniques","authors":"Haniye Jafari, Mojtaba Esmailpour Roshan","doi":"10.31557/apjcb.2023.8.4.387-393","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.387-393","url":null,"abstract":"Skin is the most important part of the human body, protecting the muscles, bones and the entire body. One of the most common diseases affecting many people today is cancer, and skin cancer is one of the most common cancers known to man. As one of the deadliest cancers, skin cancer requires special attention. Skin cancer is caused by genetic defects or mutations caused by unreduced deoxyribonucleic acid in skin cells. One of the most dangerous types of skin cancer is melanoma, which has a high survival rate if detected early. Accordingly, early detection of melanoma is very important. To this end, this paper presents a computer-aided method that uses image processing tools to detect skin cancer, especially melanoma. This system takes an image of a skin lesion and uses new image processing techniques to determine the presence of skin cancer. The lesion image analysis tool evaluates various features of melanoma, including asymmetry, contour, color, diameter (ABCD), and more. Then these extracted parameters are used to classify the images as benign or malignant lesions. This article describes methods and approaches for automatic skin cancer detection. This article provides researchers with useful information about the methods, databases, and procedures required for early detection of skin cancer.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-28DOI: 10.31557/apjcb.2023.8.4.407-408
N. Agarwal, Dhirendra Nath Choudhury, Akshit Minocha
Colorectal adenomas are polyps that develop from the mucosa and exhibit neoplastic characteristics. Adenomas’ increasing dysplasia and malignant potential are connected to their size, villous content, and patient’s age. An anorectal emergency is definitely a possibility when there are large villous polyps in the rectum. They could be involved in rectal bleeding, blockage, prolapse, or imprisonment. We describe a 53-year-old female who was treated successfully for giant tubulovillous rectal adenoma that was prolapsed through anal opening. The patient’s clinical symptoms and signs were mistaken for prolapsed hemorrhoids.
{"title":"Rectal Polyp Prolapse: A Case Report","authors":"N. Agarwal, Dhirendra Nath Choudhury, Akshit Minocha","doi":"10.31557/apjcb.2023.8.4.407-408","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.407-408","url":null,"abstract":"Colorectal adenomas are polyps that develop from the mucosa and exhibit neoplastic characteristics. Adenomas’ increasing dysplasia and malignant potential are connected to their size, villous content, and patient’s age. An anorectal emergency is definitely a possibility when there are large villous polyps in the rectum. They could be involved in rectal bleeding, blockage, prolapse, or imprisonment. We describe a 53-year-old female who was treated successfully for giant tubulovillous rectal adenoma that was prolapsed through anal opening. The patient’s clinical symptoms and signs were mistaken for prolapsed hemorrhoids.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-28DOI: 10.31557/apjcb.2023.8.4.339-343
Shridhar C. Ghagane, Rangrez Shadab, R. Nerli, Shreyas Rai, Madhukar L. Thakur, L. Gomella
Introduction: Prostate cancer (PCa) cells are known to be shed into the prostatic urethra and thus can be collected through a voided urine sample. In this preliminary prospective study, we have assessed the feasibility of detecting cancer of the prostate using a voided urine sample and targeting the genomic VPAC receptors in patients with lower urinary tract symptoms and a serum PSA ranging between 2.6 to 10 ng/mL. Materials & Methods: Patients ≥40 years old, with lower urinary tract symptoms and serum prostate-specific antigen (PSA) ranging between 2.6 - 10 ng/mL formed the study group. The voided urine sample was collected from all these patients for biomarker testing. All patients underwent a standard 12-core prostate biopsy. The results of the histopathological studies were then compared to the results of the urine biomarker. Results: A total of 76 male subjects presented to our hospital with lower urinary tract symptoms and a serum PSA ≥ 2.6 and ≤ 10 ng/mL. The voided urine sample was positive for malignant cells in 24/25 (96%) patients with PCa. There was one case of a false negative in this group. Histopathological examination of the core biopsy specimens was positive for malignancy in 23 (92%) cases of PCa. Conclusions: Voided urine samples can be used to diagnose PCa by targeting the VPAC receptors that are expressed on malignant cells. This test is highly sensitive and serum PSA levels or Gleason’s score have no impact on the sensitivity of this test.
{"title":"Voided Urine Sample in the Diagnosis of Prostate Cancer in Patients with Serum PSA Ranging between 2.6 to 10 ng/mL","authors":"Shridhar C. Ghagane, Rangrez Shadab, R. Nerli, Shreyas Rai, Madhukar L. Thakur, L. Gomella","doi":"10.31557/apjcb.2023.8.4.339-343","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.339-343","url":null,"abstract":"Introduction: Prostate cancer (PCa) cells are known to be shed into the prostatic urethra and thus can be collected through a voided urine sample. In this preliminary prospective study, we have assessed the feasibility of detecting cancer of the prostate using a voided urine sample and targeting the genomic VPAC receptors in patients with lower urinary tract symptoms and a serum PSA ranging between 2.6 to 10 ng/mL. Materials & Methods: Patients ≥40 years old, with lower urinary tract symptoms and serum prostate-specific antigen (PSA) ranging between 2.6 - 10 ng/mL formed the study group. The voided urine sample was collected from all these patients for biomarker testing. All patients underwent a standard 12-core prostate biopsy. The results of the histopathological studies were then compared to the results of the urine biomarker. Results: A total of 76 male subjects presented to our hospital with lower urinary tract symptoms and a serum PSA ≥ 2.6 and ≤ 10 ng/mL. The voided urine sample was positive for malignant cells in 24/25 (96%) patients with PCa. There was one case of a false negative in this group. Histopathological examination of the core biopsy specimens was positive for malignancy in 23 (92%) cases of PCa. Conclusions: Voided urine samples can be used to diagnose PCa by targeting the VPAC receptors that are expressed on malignant cells. This test is highly sensitive and serum PSA levels or Gleason’s score have no impact on the sensitivity of this test.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-22DOI: 10.31557/apjcb.2023.8.4.379-386
Elham Saberian, Andrej Jenča, A. Petrášová, J. Jenčová, Reza Atazadegan Jahromi, Rahman Seiffadini
Overview: This review aims to serve as a comprehensive resource for healthcare professionals, researchers, and students interested in oral cancer, providing them with up-to-date information and insights into the current state of knowledge and practice in the field. Oral cancer, also known as mouth cancer, is a type of cancer that affects the mouth, tongue, lips, or throat. It is a common form of cancer worldwide, and its incidence is increasing annually. Oral cancer can be life-threatening if not detected early and treated promptly. Methods: We searched the PubMed database, Web of Science (WOS), Google Scholar, Scopus, and selected studies by predefined eligibility criteria. This review aims to provide an overview of oral cancer, including its causes, risk factors, signs and symptoms, diagnosis, treatment options, and prevention strategies. Result: Oral cancer is a preventable disease, and ongoing research is providing valuable insights into its risk factors and development. With this increasing knowledge, healthcare professionals have the opportunity to improve clinical outcomes by developing better early detection and treatment strategies. By staying up-to-date with the latest advancements in biomedical sciences and dentistry, they can make a significant impact on patient outcomes and save lives. Conclusion: summarizing the key points discussed in the review and highlighting the significance of continued research and awareness efforts to combat this complex and aggressive disease.
概述：本综述旨在为对口腔癌感兴趣的医疗保健专业人员、研究人员和学生提供全面的资源，为他们提供最新的信息以及对该领域知识和实践现状的见解。口腔癌又称口腔癌，是一种影响口腔、舌头、嘴唇或咽喉的癌症。它是全球常见的一种癌症，发病率逐年上升。如果不及早发现和及时治疗，口腔癌可能会危及生命。研究方法我们检索了 PubMed 数据库、Web of Science (WOS)、Google Scholar、Scopus，并按照预先确定的资格标准筛选了一些研究。本综述旨在概述口腔癌，包括其病因、风险因素、体征和症状、诊断、治疗方案和预防策略。结果：口腔癌是一种可预防的疾病，正在进行的研究对其风险因素和发展提供了宝贵的见解。随着知识的增长，医疗保健专业人员有机会通过制定更好的早期检测和治疗策略来改善临床效果。通过了解生物医学和牙科领域的最新进展，他们可以对患者的治疗效果和挽救生命产生重大影响。结语：总结综述中讨论的要点，并强调继续开展研究和提高认识的努力对于防治这种复杂且具有侵袭性的疾病具有重要意义。
{"title":"Oral Cancer at a Glance","authors":"Elham Saberian, Andrej Jenča, A. Petrášová, J. Jenčová, Reza Atazadegan Jahromi, Rahman Seiffadini","doi":"10.31557/apjcb.2023.8.4.379-386","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.379-386","url":null,"abstract":"Overview: This review aims to serve as a comprehensive resource for healthcare professionals, researchers, and students interested in oral cancer, providing them with up-to-date information and insights into the current state of knowledge and practice in the field. Oral cancer, also known as mouth cancer, is a type of cancer that affects the mouth, tongue, lips, or throat. It is a common form of cancer worldwide, and its incidence is increasing annually. Oral cancer can be life-threatening if not detected early and treated promptly. Methods: We searched the PubMed database, Web of Science (WOS), Google Scholar, Scopus, and selected studies by predefined eligibility criteria. This review aims to provide an overview of oral cancer, including its causes, risk factors, signs and symptoms, diagnosis, treatment options, and prevention strategies. Result: Oral cancer is a preventable disease, and ongoing research is providing valuable insights into its risk factors and development. With this increasing knowledge, healthcare professionals have the opportunity to improve clinical outcomes by developing better early detection and treatment strategies. By staying up-to-date with the latest advancements in biomedical sciences and dentistry, they can make a significant impact on patient outcomes and save lives. Conclusion: summarizing the key points discussed in the review and highlighting the significance of continued research and awareness efforts to combat this complex and aggressive disease.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"268 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcb.2023.8.4.335-338
Anak Agung Ayu Niti Wedayani, Abdul Qadar Punagi, Nova Audrey, Husni Cangara, David Giffard Kawi Junior, Ricky Setiadi Yusuf
Background: Formaldehyde is known as a chemical substance that may induce structural cell changes in several organs, especially the respiratory system. Different concentrations of exposure may result in different degrees of severity in histopathology. Method: Twenty male Wistar rats were divided into 4 groups. Inhalation of 10% formaldehyde exposure in 6 hours per day over 16 weeks was done. Nasopharyngeal and lung tissues were taken with hematoxylin-eosin (H&E) staining to see histopathology structural changes and degree of severity. Bivariate analysis was conducted to find the correlation coefficient. Results: This experimental study found that severe dysplasia is correlated with long exposure. A strong correlation is found between concentrations and dysplasia (r=0.682), and a moderate correlation between duration of exposure and dysplasia (r=0.488).Discussion: Dysplasia of nasopharyngeal and lung tissue are in line with exposure of formaldehyde in rats. Formaldehyde exposure with 10 ppm and 15 ppm may lead to structural cell changes such as vacuolar degeneration, cell necrosis, epithelial exfoliation, and erosion in nasal passage. Also, longer exposure increases the severity of dysplasia. Squamous metaplasia was found in 20 ppm of formaldehyde over 2 weeks of exposure, in the epithelial respiratory system. Conclusion: The severity of dysplasia in rats is in line with the duration and concentrations of formaldehyde exposure. Long exposure will increase the severity of dysplasia and, similarly, high concentration of formaldehyde exposure increases the severity of dysplasia.
{"title":"Differences in Nasopharyngeal and Lung Histopathology in Wistar Rats (Rattus norvegicus) Given Inhaled Formaldehyde Exposure with Doses of 20, 30, and 40 ppm","authors":"Anak Agung Ayu Niti Wedayani, Abdul Qadar Punagi, Nova Audrey, Husni Cangara, David Giffard Kawi Junior, Ricky Setiadi Yusuf","doi":"10.31557/apjcb.2023.8.4.335-338","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.335-338","url":null,"abstract":"Background: Formaldehyde is known as a chemical substance that may induce structural cell changes in several organs, especially the respiratory system. Different concentrations of exposure may result in different degrees of severity in histopathology. Method: Twenty male Wistar rats were divided into 4 groups. Inhalation of 10% formaldehyde exposure in 6 hours per day over 16 weeks was done. Nasopharyngeal and lung tissues were taken with hematoxylin-eosin (H&E) staining to see histopathology structural changes and degree of severity. Bivariate analysis was conducted to find the correlation coefficient. Results: This experimental study found that severe dysplasia is correlated with long exposure. A strong correlation is found between concentrations and dysplasia (r=0.682), and a moderate correlation between duration of exposure and dysplasia (r=0.488).Discussion: Dysplasia of nasopharyngeal and lung tissue are in line with exposure of formaldehyde in rats. Formaldehyde exposure with 10 ppm and 15 ppm may lead to structural cell changes such as vacuolar degeneration, cell necrosis, epithelial exfoliation, and erosion in nasal passage. Also, longer exposure increases the severity of dysplasia. Squamous metaplasia was found in 20 ppm of formaldehyde over 2 weeks of exposure, in the epithelial respiratory system. Conclusion: The severity of dysplasia in rats is in line with the duration and concentrations of formaldehyde exposure. Long exposure will increase the severity of dysplasia and, similarly, high concentration of formaldehyde exposure increases the severity of dysplasia.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-07DOI: 10.31557/apjcb.2023.8.4.417-421
Eman Al-Balushi, Amina Al-Marzouqi, Shima Tavoosi, Amir Hossein Baghsheikhi, Arash Sadri, Leyla Sharifi Aliabadi, Mohammad-Mahdi Salarabedi, Syed Azizur Rahman, Nabeel Al-Yateem, Alizera Mosavi Jarrahi, Aram Halimi, Mohammad Ahmadvand, Wael M Abdel-Rahman
Background: This systematic review aims to comprehensively assess and synthesize the current body of evidence regarding the role of ubiquitin-specific peptidases in colorectal cancer. Methods: This protocol adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) and was officially registered with the International Prospective Register for Systematic Reviews (PROSPERO) under the registration number CRD42022348183. Results: This study will provide a concise summary of the synthesized data from the included studies and will synthesize key findings, explore clinical and therapeutic implications, address limitations and gaps in knowledge, and propose avenues for future research.Conclusion: This section will conclude by summarizing the key takeaways from the systematic review and emphasizing the relevance of the findings in advancing our knowledge of the role of USPs in colorectal cancer. It will also underscore the potential implications for clinical practice and future research directions.
{"title":"The Role of Ubiquitin-specific Peptidases in Colorectal Cancer: A Systematic Review Protocol","authors":"Eman Al-Balushi, Amina Al-Marzouqi, Shima Tavoosi, Amir Hossein Baghsheikhi, Arash Sadri, Leyla Sharifi Aliabadi, Mohammad-Mahdi Salarabedi, Syed Azizur Rahman, Nabeel Al-Yateem, Alizera Mosavi Jarrahi, Aram Halimi, Mohammad Ahmadvand, Wael M Abdel-Rahman","doi":"10.31557/apjcb.2023.8.4.417-421","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.417-421","url":null,"abstract":"Background: This systematic review aims to comprehensively assess and synthesize the current body of evidence regarding the role of ubiquitin-specific peptidases in colorectal cancer. Methods: This protocol adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) and was officially registered with the International Prospective Register for Systematic Reviews (PROSPERO) under the registration number CRD42022348183. Results: This study will provide a concise summary of the synthesized data from the included studies and will synthesize key findings, explore clinical and therapeutic implications, address limitations and gaps in knowledge, and propose avenues for future research.Conclusion: This section will conclude by summarizing the key takeaways from the systematic review and emphasizing the relevance of the findings in advancing our knowledge of the role of USPs in colorectal cancer. It will also underscore the potential implications for clinical practice and future research directions.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"298 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135254002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-07DOI: 10.31557/apjcb.2023.8.4.319-325
P. Bhati, Saumya Gupta, Monal Garg, N. Puthenveettil, Indu R. Nair, A. Rajanbabu
Objective: To determine the detection rates and location of sentinel nodes as well as to determine intraoperative and postoperative surgico-pathological outcomes in endometrial cancer patients who underwent laparoscopic staging with sentinel node biopsy using ICG dye. Materials and Methods: This retrospective study was conducted in a tertiary care oncology centre, Amrita Institute of medical sciences, Kochi from April 2021 to March 2023. All cases of biopsy proven early stage endometrial carcinoma that underwent laparoscopic staging with SLN mapping using the ICG dye were included. All histological types were included, as long as the disease was confined to the uterus, clinically and on MRI. Results: A total of 80 patients were found eligible for the study. Only the patients with apparent uterine confined disease on preoperative MRI were selected for sentinel mapping, 80 % of whom had IA disease on MRI, and 20 % had IB, 13.5 % were high grade histology.The overall SLN detection rate was 93.75%, and bilateral detection rate was 92.5 %. Most common location was external iliac in 40.8% cases. Only 1 patient was found to harbour nodal micro metastasis on ultrastaging. Final histopathology identified stage IA in 63 (78.75%) patients, IB in 14 (17.5%), Stage II in 2 (2.5%) and Stage IIIC1 in 1 (1.25%) patient. Conclusion: Laparoscopic staging with SLNB using ICG is a practicable approach for uterine limited disease on preoperative evaluation. It extends the benefits of minimally invasive surgery to these patients, while overcoming the limitations of prohibitive cost or availability of expensive robotic equipment.
{"title":"Laparoscopic Sentinel Lymph Node Mapping Using NIR Fluorescence with ICG in Early Endometrial Cancer: Experience at a Tertiary Care Oncology Centre","authors":"P. Bhati, Saumya Gupta, Monal Garg, N. Puthenveettil, Indu R. Nair, A. Rajanbabu","doi":"10.31557/apjcb.2023.8.4.319-325","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.319-325","url":null,"abstract":"Objective: To determine the detection rates and location of sentinel nodes as well as to determine intraoperative and postoperative surgico-pathological outcomes in endometrial cancer patients who underwent laparoscopic staging with sentinel node biopsy using ICG dye. Materials and Methods: This retrospective study was conducted in a tertiary care oncology centre, Amrita Institute of medical sciences, Kochi from April 2021 to March 2023. All cases of biopsy proven early stage endometrial carcinoma that underwent laparoscopic staging with SLN mapping using the ICG dye were included. All histological types were included, as long as the disease was confined to the uterus, clinically and on MRI. Results: A total of 80 patients were found eligible for the study. Only the patients with apparent uterine confined disease on preoperative MRI were selected for sentinel mapping, 80 % of whom had IA disease on MRI, and 20 % had IB, 13.5 % were high grade histology.The overall SLN detection rate was 93.75%, and bilateral detection rate was 92.5 %. Most common location was external iliac in 40.8% cases. Only 1 patient was found to harbour nodal micro metastasis on ultrastaging. Final histopathology identified stage IA in 63 (78.75%) patients, IB in 14 (17.5%), Stage II in 2 (2.5%) and Stage IIIC1 in 1 (1.25%) patient. Conclusion: Laparoscopic staging with SLNB using ICG is a practicable approach for uterine limited disease on preoperative evaluation. It extends the benefits of minimally invasive surgery to these patients, while overcoming the limitations of prohibitive cost or availability of expensive robotic equipment.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139322053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-07DOI: 10.31557/apjcb.2023.8.4.327-333
U. Sarma, Purashree Sarma, Dhanashri Rabha
Background: Various non-neoplastic and neoplastic lesions occur in cervix. HPV infection plays a major role in genesis of cervical lesions. Although most HPV infections are cleared out, infections with high risk HPVs may persist resulting in cervical dysplastic lesions. Using p16, a surrogate marker for HPV infection and Ki-67, a proliferation marker, along with histopathology, help improve the diagnostic accuracy of these lesions. The aim of the study was to evaluate the expression of p16 and Ki-67 in cervical lesions and association of their staining intensity with the histologic grading. Also to determine the predictive value of these markers in association with the cervical lesions. Methodology: A cross sectional study was carried out in 122 cases which were diagnosed histopathologically and then evaluated for the immunohistochemical expression of p16 and Ki-67 and their staining intensities. Results: The dysplastic lesions comprised of 83.7% cases [29.5% LSIL, 5.7% HSIL, 43.5% SCC and 4.9% adenocarcinoma] and 16.3% had non dysplastic lesions. p16 and Ki-67 expression were seen in 64.7% and 68% cases respectively. The intensity of p16 and Ki-67 expression was scored according to Galgano et al (2010). An increasing intensity of p16 and Ki-67 expression with higher grades of the cervical lesions was noted and this association was found to be statistically significant. (χ2 = 43.46 and p value < 0.0001). Conclusion: Though histopathology is the gold standard, the role of p16 and Ki-67 have emerged as useful adjuncts in detecting the true nature of the cervical lesions. They aid in the proper diagnosis, classification and distinction from non-dysplastic lesions, helping the clinicians in taking prompt action for management of the cases.
{"title":"Staining Intensity of P16INK4a and Ki-67 Determine the Grade of Cervical Lesion: An Experience from Single Tertiary Care Centre","authors":"U. Sarma, Purashree Sarma, Dhanashri Rabha","doi":"10.31557/apjcb.2023.8.4.327-333","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.327-333","url":null,"abstract":"Background: Various non-neoplastic and neoplastic lesions occur in cervix. HPV infection plays a major role in genesis of cervical lesions. Although most HPV infections are cleared out, infections with high risk HPVs may persist resulting in cervical dysplastic lesions. Using p16, a surrogate marker for HPV infection and Ki-67, a proliferation marker, along with histopathology, help improve the diagnostic accuracy of these lesions. The aim of the study was to evaluate the expression of p16 and Ki-67 in cervical lesions and association of their staining intensity with the histologic grading. Also to determine the predictive value of these markers in association with the cervical lesions. Methodology: A cross sectional study was carried out in 122 cases which were diagnosed histopathologically and then evaluated for the immunohistochemical expression of p16 and Ki-67 and their staining intensities. Results: The dysplastic lesions comprised of 83.7% cases [29.5% LSIL, 5.7% HSIL, 43.5% SCC and 4.9% adenocarcinoma] and 16.3% had non dysplastic lesions. p16 and Ki-67 expression were seen in 64.7% and 68% cases respectively. The intensity of p16 and Ki-67 expression was scored according to Galgano et al (2010). An increasing intensity of p16 and Ki-67 expression with higher grades of the cervical lesions was noted and this association was found to be statistically significant. (χ2 = 43.46 and p value < 0.0001). Conclusion: Though histopathology is the gold standard, the role of p16 and Ki-67 have emerged as useful adjuncts in detecting the true nature of the cervical lesions. They aid in the proper diagnosis, classification and distinction from non-dysplastic lesions, helping the clinicians in taking prompt action for management of the cases.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139322014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-07DOI: 10.31557/apjcb.2023.8.4.403-405
K. Akhtar, A. Abrari, RachelCynthia Tirkey
Pseudo-invasive, vasculocentric adenomyosis is a rare benign lesion of the uterus, characterized by the aberrant, pathological presence of variable sized, non-neoplastic endometrial glands and surrounded by endometrial stroma deep within the myometrial blood vessels. This condition usually affects multiparous women in their fourth and fifth decades, with other risk factors being prior caesarian surgery or uterine surgery. Mostly the patients present with abnormal uterine bleeding, pelvic pain, dysmenorrhea, dyspareunia, or infertility while a third of them may be asymptomatic. Microscopic examination of hysterectomy specimens remains the gold standard to make a definitive diagnosis. Herein we present a rare case of Pseudo-invasive, vasculocentric Adenomyosis in a 47 year old multigravida female, who presented with a history of chronic pelvic pain with menorrhagia, dyspareunia and excessive menstrual bleeding for the past four months, with a history of lower uterine caesarean section a decade ago.
{"title":"Pseudo-invasive Vasculocentric Adenomyosis- A Diagnostic Dilemma","authors":"K. Akhtar, A. Abrari, RachelCynthia Tirkey","doi":"10.31557/apjcb.2023.8.4.403-405","DOIUrl":"https://doi.org/10.31557/apjcb.2023.8.4.403-405","url":null,"abstract":"Pseudo-invasive, vasculocentric adenomyosis is a rare benign lesion of the uterus, characterized by the aberrant, pathological presence of variable sized, non-neoplastic endometrial glands and surrounded by endometrial stroma deep within the myometrial blood vessels. This condition usually affects multiparous women in their fourth and fifth decades, with other risk factors being prior caesarian surgery or uterine surgery. Mostly the patients present with abnormal uterine bleeding, pelvic pain, dysmenorrhea, dyspareunia, or infertility while a third of them may be asymptomatic. Microscopic examination of hysterectomy specimens remains the gold standard to make a definitive diagnosis. Herein we present a rare case of Pseudo-invasive, vasculocentric Adenomyosis in a 47 year old multigravida female, who presented with a history of chronic pelvic pain with menorrhagia, dyspareunia and excessive menstrual bleeding for the past four months, with a history of lower uterine caesarean section a decade ago.","PeriodicalId":8848,"journal":{"name":"Asian Pacific Journal of Cancer Biology","volume":"238 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139322012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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