Pub Date : 2026-03-21DOI: 10.1186/s12896-026-01124-2
Mohamed K Y Soliman, Mai M El-Ashmony, Hager A Bendary, Fatma Rasslan, Salem S Salem
{"title":"Phyto mediated synthesis of copper oxide nanoparticles with Zingiber officinale: comprehensive bioactivity assessment against bacterial pathogens, cancer, and viruses.","authors":"Mohamed K Y Soliman, Mai M El-Ashmony, Hager A Bendary, Fatma Rasslan, Salem S Salem","doi":"10.1186/s12896-026-01124-2","DOIUrl":"https://doi.org/10.1186/s12896-026-01124-2","url":null,"abstract":"","PeriodicalId":8905,"journal":{"name":"BMC Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1186/s12896-026-01131-3
Yunhee Chang, Jun-Young Park, Dasom Hwang, Min Tae Kim, Seyeon Yoon, Seung-Hak Cho
{"title":"A novel method to encapsulate polydeoxyribonucleotides extracted from trout into exosomes and applications in skin recovery.","authors":"Yunhee Chang, Jun-Young Park, Dasom Hwang, Min Tae Kim, Seyeon Yoon, Seung-Hak Cho","doi":"10.1186/s12896-026-01131-3","DOIUrl":"https://doi.org/10.1186/s12896-026-01131-3","url":null,"abstract":"","PeriodicalId":8905,"journal":{"name":"BMC Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1186/s12896-026-01134-0
Li Zhang, Juan Luo, Chuanguang Zhang, Hong Wang, Mingjie Yan, Naiming Zhang, Yunsheng Xia, Xianrong Yue
{"title":"Sustainable utilization of phosphogypsum in agriculture enhanced by mycorrhizal organisms: a new perspective.","authors":"Li Zhang, Juan Luo, Chuanguang Zhang, Hong Wang, Mingjie Yan, Naiming Zhang, Yunsheng Xia, Xianrong Yue","doi":"10.1186/s12896-026-01134-0","DOIUrl":"https://doi.org/10.1186/s12896-026-01134-0","url":null,"abstract":"","PeriodicalId":8905,"journal":{"name":"BMC Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1186/s12896-026-01123-3
Wenting Xing, Dongmei Huang, Bin Wu, Funing Ma, Haijie Huang, Shun Song, Yi Xu
{"title":"Breaking the barrier of interspecific recalcitrance: a unified and efficient in vitro conservation system for Passiflora germplasm.","authors":"Wenting Xing, Dongmei Huang, Bin Wu, Funing Ma, Haijie Huang, Shun Song, Yi Xu","doi":"10.1186/s12896-026-01123-3","DOIUrl":"https://doi.org/10.1186/s12896-026-01123-3","url":null,"abstract":"","PeriodicalId":8905,"journal":{"name":"BMC Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1186/s12896-026-01119-z
Jannatul Firdous Siddique, G R Shree Kumari, Sudarshana Deepa Vijay Kumar, C Subathra Devi, Mohanasrinivasan Vaithilingam
{"title":"p53 mediated cell cytotoxicity and DNA damage in lung cancer cell line A549 triggered by a small peptide extracted from a probiotic strain Lacticaseibacillus casei.","authors":"Jannatul Firdous Siddique, G R Shree Kumari, Sudarshana Deepa Vijay Kumar, C Subathra Devi, Mohanasrinivasan Vaithilingam","doi":"10.1186/s12896-026-01119-z","DOIUrl":"https://doi.org/10.1186/s12896-026-01119-z","url":null,"abstract":"","PeriodicalId":8905,"journal":{"name":"BMC Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1186/s12896-026-01108-2
Mohamed Abdelraof, Ghada S A Abdel Karim, Alshaimaa M Elsayed, Abdelmageed M Othman
Background: Biological approaches, which involve applying the entire microbial cell or its released enzymes, provide an effective substitute for traditional techniques. By employing statistical optimization methodologies, key fermentation parameters can be precisely tuned to maximize enzyme yield.
Results: Penicillium commune S6, a fungal isolate useful for laccase synthesis in solid-state fermentation employing a variety of phenolic-rich agri-food wastes, was identified by 18 S rRNA sequencing. By applying potato peel waste as solid-state fermentation substrate for 30 days of incubation at 30 °C, pH 8.0, 60% moisture content, and 4 mM CuSO4 using the inoculum size of 7.5%, P. commune S6 reached its maximal laccase production level, as determined by the one factor at a time (OFAT) technique. Laccase production would reach 6.20 U/gds at 2.71 mM CuSO4, 46 days of incubation, 12.64 g/flask of PPW content, and pH 9.13, according to response surface methodology (RSM) results. The laccase production levels predicted by the model and the actual experimental data showed a very good agreement, as indicated by the ANOVA analysis. P. commune S6 laccase was evaluated as a green alternative in dye decolorization, where it was found to be able to decolorize the Acid Dye Lanapel Red BM 143-PL at concentrations of 10, 25, and 50 mg L- 1 by 100, 64.08, and 36.86% after 120 min, which suggest that P. commune S6 laccase is likely useful in the biotechnological and industrial uses under milder circumstances.
Conclusion: The integrated approach not only valorizes low-cost agro-industrial byproducts but also provides a robust, eco-friendly biocatalyst for wastewater treatment, highlighting a promising circular economy strategy for textile effluent detoxification.
背景：生物学方法，包括应用整个微生物细胞或其释放的酶，是传统技术的有效替代品。通过采用统计优化方法，关键发酵参数可以精确调整，以最大限度地提高酶产量。结果：通过18s rRNA测序鉴定出了一株可用于利用多种富含酚的农业食品废弃物进行固态发酵合成漆酶的真菌分离株青霉菌公社S6。以马铃薯皮渣为固体发酵底物，在30℃、pH 8.0、60%含水率、4 mM CuSO4、7.5%接种量条件下培养30天，经一次一因子法（OFAT）测定，P. commune S6达到了最大漆酶产量。根据响应面法（RSM）结果，在2.71 mM CuSO4、培养46 d、PPW含量12.64 g/flask、pH 9.13条件下，漆酶产量可达6.20 U/gds。方差分析表明，模型预测的漆酶产量水平与实际实验数据吻合良好。P. commune S6漆酶被评价为染料脱色的绿色替代品，在浓度为10、25和50 mg L- 1的情况下，120分钟后，它对酸性染料Lanapel Red BM 143-PL的脱色率分别为100、64.08和36.86%，这表明P. commune S6漆酶可能在较温和的环境下用于生物技术和工业用途。结论：综合方法不仅可以降低农业工业副产品的成本，而且为废水处理提供了一种强大的、环保的生物催化剂，突出了纺织废水解毒的循环经济策略。
{"title":"Boosting laccase production by Penicillium commune s6 via solid-state fermentation on phenolic agri-wastes: statistical enhancement and bioremediation application in dye decolorization.","authors":"Mohamed Abdelraof, Ghada S A Abdel Karim, Alshaimaa M Elsayed, Abdelmageed M Othman","doi":"10.1186/s12896-026-01108-2","DOIUrl":"https://doi.org/10.1186/s12896-026-01108-2","url":null,"abstract":"<p><strong>Background: </strong>Biological approaches, which involve applying the entire microbial cell or its released enzymes, provide an effective substitute for traditional techniques. By employing statistical optimization methodologies, key fermentation parameters can be precisely tuned to maximize enzyme yield.</p><p><strong>Results: </strong>Penicillium commune S6, a fungal isolate useful for laccase synthesis in solid-state fermentation employing a variety of phenolic-rich agri-food wastes, was identified by 18 S rRNA sequencing. By applying potato peel waste as solid-state fermentation substrate for 30 days of incubation at 30 °C, pH 8.0, 60% moisture content, and 4 mM CuSO<sub>4</sub> using the inoculum size of 7.5%, P. commune S6 reached its maximal laccase production level, as determined by the one factor at a time (OFAT) technique. Laccase production would reach 6.20 U/gds at 2.71 mM CuSO<sub>4</sub>, 46 days of incubation, 12.64 g/flask of PPW content, and pH 9.13, according to response surface methodology (RSM) results. The laccase production levels predicted by the model and the actual experimental data showed a very good agreement, as indicated by the ANOVA analysis. P. commune S6 laccase was evaluated as a green alternative in dye decolorization, where it was found to be able to decolorize the Acid Dye Lanapel Red BM 143-PL at concentrations of 10, 25, and 50 mg L<sup>- 1</sup> by 100, 64.08, and 36.86% after 120 min, which suggest that P. commune S6 laccase is likely useful in the biotechnological and industrial uses under milder circumstances.</p><p><strong>Conclusion: </strong>The integrated approach not only valorizes low-cost agro-industrial byproducts but also provides a robust, eco-friendly biocatalyst for wastewater treatment, highlighting a promising circular economy strategy for textile effluent detoxification.</p>","PeriodicalId":8905,"journal":{"name":"BMC Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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