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Sigma-1 receptors: a new pathway for the modulation of store-operated calcium entry. Sigma-1受体:调节储存操作钙离子进入的新途径。
Pub Date : 2016-02-01 DOI: 10.1042/BJ20151144
Juan A Rosado

SOCE (store-operated Ca(2+) entry) is a ubiquitous mechanism for Ca(2+) influx in animal cells. In a recent issue of the Biochemical Journal, Brailoiu and colleagues reported that cocaine attenuates SOCE in rat brain microvascular endothelial cells, via a mechanism that requires the expression and activation of the sigma-1 receptor, a chaperone located in the endoplasmic reticulum-mitochondrion interface that modulates intracellular Ca(2+) homoeostasis and cell survival. This study envisages a pathway through which cocaine modulates endothelial function via regulation of SOCE. The regulation of SOCE by sigma-1 receptors provides a novel and important pathway in Ca(2+) signalling.

SOCE(贮存操作的 Ca(2+) 进入)是动物细胞中一种普遍存在的 Ca(2+) 流入机制。在最近一期《生化杂志》上,Brailoiu 及其同事报告说,可卡因通过一种需要 sigma-1 受体表达和激活的机制,减弱了大鼠脑微血管内皮细胞中的 SOCE,sigma-1 受体是一种位于内质网-线粒体界面的伴侣蛋白,可调节细胞内 Ca(2+) 的平衡和细胞存活。本研究设想了可卡因通过调节 SOCE 来调节内皮功能的途径。sigma-1 受体对 SOCE 的调控为 Ca(2+) 信号传导提供了一个新的重要途径。
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引用次数: 5
High Dimensional Regression on Serum Analytes 血清分析物的高维回归
Pub Date : 2012-12-31 DOI: 10.2427/8672
Yuanzhang Li, E. Schwarz, S. Bahn, R. Yolken, D. Niebuhr
Regression of high dimensional data is particularly difficult when the number of observations is limited. Principal Component Analysis, canonical correlation analysis and factor analysis are commonly used methods to reduce data dimensions, but usually cannot find the most significant linear combination. The goal is usually to find a particular partition of the space X consisting of all independent factors. In this paper, we propose an approach to high dimensional regression for applications where N>K or N
当观测值有限时,高维数据的回归尤其困难。主成分分析、典型相关分析和因子分析是常用的数据降维方法,但往往找不到最显著的线性组合。目标通常是找到由所有独立因子组成的空间X的特定分区。本文针对N>K或N
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引用次数: 2
Time to revisit Geoffrey Rose: strategies for prevention in the genomic era? 是时候重温杰弗里·罗斯:基因组时代的预防策略了?
Pub Date : 2012-12-21 DOI: 10.2427/8665
H. Burton, G. Sagoo, P. Pharoah, R. Zimmern
Geoffrey Rose, in his article “Sick individuals and sick populations” highlighted the need to distinguish between prevention for populations and prevention for high risk individuals. In this article we revisit some of these concepts in light of the burgeoning literature on “personalised medicine” and of findings from our investigations into personalised cancer prevention as part of an EU research gene-environment study on hormone related cancers, the Collaborative Oncological Gene- environment Study (COGS). We suggest that Rose’s high risk strategy may be modified by segmenting the population by risk (in our example genetic risk) into a number of individual strata, to each of which differential interventions may be applied. We call this “stratified prevention”, and argue that such an approach will lead to consequential advantages in efficiency, effectiveness and harm minimisation.
Geoffrey Rose在他的文章“患病个体和患病人群”中强调,需要区分针对人群的预防和针对高危人群的预防。在这篇文章中,我们根据新兴的“个体化医学”文献,以及我们对个体化癌症预防的调查结果,重新审视了其中的一些概念。个体化癌症预防是欧盟研究激素相关癌症的基因环境研究的一部分,即肿瘤基因环境研究(COGS)。我们建议,罗斯的高风险策略可以通过根据风险(在我们的例子中是遗传风险)将人群划分为许多单独的阶层来修改,每个阶层都可以应用不同的干预措施。我们称之为“分层预防”,并认为这种方法将在效率、有效性和危害最小化方面带来相应的优势。
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引用次数: 29
Female genital mutilation of minors in Italy: is a harmless and symbolic alternative justified? 意大利未成年女性生殖器切割:一种无害且象征性的替代方法是合理的吗?
Pub Date : 2012-09-13 DOI: 10.2427/7533
M. Pietro, A. A. Teleman, M. Faggioni
In 2004, Omar Abdulcadir - a gynecologist of the Centre for the prevention and therapy of female genital mutilation (FMG) at the Careggi Hospital (Florence) - proposed a “harmless and symbolic” alternative to FMG, which consists in the puncture of the clitoris under local anesthesia, in order to allow the outflow of some drops of blood (1). The intention behind the symbolic alternative is to avoid more severe forms of FGM while respecting cultural heritage. The proposal of this alternative procedure, which was sustained by the leaders of 10 local African immigrant communities, has encountered ample criticism (1). However, the question is: is the puncture of the clitoris prohibited by the Italian Law n. 7/2006? If it is not, could it be considered a method of reducing health risks caused by the more invasive forms of FGM (2)? Or could it culturally legitimize FGM, causing a greater difficulty in the attempts to prevent and eradicate FGM in Italy?
2004年,佛罗伦萨Careggi医院切割女性生殖器官预防和治疗中心的妇科医生Omar Abdulcadir提出了一种“无害和象征性”的替代方法,即在局部麻醉下刺穿阴蒂,以便流出几滴血(1)。这种象征性替代方法的意图是在尊重文化遗产的同时避免更严重的切割女性生殖器官形式。这个由10个当地非洲移民社区的领导人支持的替代程序的提议遭到了大量的批评(1)。然而,问题是:意大利7/2006号法律禁止刺穿阴蒂吗?如果不是,它是否可以被认为是一种减少更具侵入性形式的女性生殖器切割造成的健康风险的方法(2)?或者它会使女性生殖器切割在文化上合法化,从而给意大利预防和根除女性生殖器切割的努力带来更大的困难?
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引用次数: 2
Body mass index and factors associated with overweight and obesity: a crosssectional in a small city of Western Sicily (Italy) 身体质量指数及与超重和肥胖相关的因素:西西里岛西部一个小城市的横断面调查(意大利)
Pub Date : 2012-09-13 DOI: 10.2427/7539
G. Calamusa, E. Amodio, C. Costantino, M. D. Pasquale, Viviana Gelsomino, M. Morici, Angelo Palmeri, Sabrina Maria Termini, A. Firenze, M. F. Massenti, F. Vitale
Background : although the epidemiological features of overweight and obesity have been well described, especially for very populous urban areas, less evidences are available for small urban areas. The aim of the present work was to assess BMI and factors associated with overweight and obesity in a representative sample of general population of a small city of Western Sicily (Italy). Methods : four hundred and eleven randomly selected adult subjects from general population living in a small Sicilian city with 7 144 inhabitants were interviewed by a standardized questionnaire investigating life-styles, eating habits, anthropometric measurements (weight, height and BMI) and socio-economic deprivation. Results : the standardized prevalence of overweight and obesity were 43.8% and 18.3%, respectively. The multivariate analysis has indicated an increased risk of BMI≥25 in subjects 40-59 years old (OR=2.3; 95% CI=1.2-4.4) in comparison with 18-39 years old, in males (OR=2.8; 95% CI=1.6-4.7) in comparison with females, and in participants who had a higher socio-economic deprivation (OR=1.3; 95% CI=1.1-1.7). Conclusions : in small urban areas some demographic factors and socio-economic deprivation can be considered important risk factors for increased BMI also after controlling for the most common confounding factors.
背景:虽然超重和肥胖的流行病学特征已经得到很好的描述,特别是在人口稠密的城市地区,但在小城市地区的证据较少。本研究的目的是评估西西里岛西部(意大利)一个小城市普通人群的代表性样本中体重指数和与超重和肥胖相关的因素。方法:采用标准化问卷对西西里某小城市7144名居民的生活方式、饮食习惯、人体测量(体重、身高、BMI)和社会经济剥夺等方面进行调查,随机抽取411名成年被试。结果:超重和肥胖标准化患病率分别为43.8%和18.3%。多因素分析表明,40-59岁受试者BMI≥25的风险增加(OR=2.3;95% CI=1.2-4.4),与18-39岁男性相比(OR=2.8;95% CI=1.6-4.7),与女性相比,社会经济剥夺程度较高的参与者(OR=1.3;95% CI = 1.1 - -1.7)。结论:在小城市地区,在控制了最常见的混杂因素后,一些人口因素和社会经济剥夺也可以被认为是BMI升高的重要危险因素。
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引用次数: 3
Health status of internationally adopted children. The experience of an Italian “GLNBI” paediatric centre 国际收养儿童的健康状况。意大利“GLNBI”儿科中心的经验
Pub Date : 2012-09-13 DOI: 10.2427/7527
P. Valentini, L. Gargiullo, M. Ceccarelli, O. Ranno
Background : according to ISTAT (National Institute of Statistics-Italy), in 2011 20.7% of the foreign population in Italy is composed by children, either coming along with their families or alone, like in international adoptions. Immigrant children have some peculiarities related to their previous living conditions, although there are no significant differences between immigrant and native children’ diseases. Methods : in 3.5 years we evaluated every adoptee that reached our university centre, by using GLNBI (Gruppo di Lavoro Nazionale del Bambino Immigrato) diagnostic – aiding protocol, in order to assess infectious diseases, nutritional deficiencies, immunization status, intestinal parasitosis or other pathologies; this protocol is actually applied only in research centres. Results : we evaluated 358 international adoptees from 4 different Zones of the world; average age at first visit was approximately 5 years. Health certifications concerning vaccination history records were considered “valid” in 59.2% (212/358), 49.5% (105/212) of which had a complete panel of immunization. QuantiFERON®_TB Gold In-Tube (QTF) test resulted negative in 94.0% cases (313/333) and positive in 6.0% (20/333). HIV, HCV and Syphilis tests resulted in 0.3% positive test for each serology (1/358). Cysticercosis’ serology was positive in 8.9% (32/358) using immunoenzymatic assay (not confirmed by immunoblotting) and Toxocariasis in 13.1% (47/358). Parasitological investigation of faeces were found positive on 42.7% (153/358) children, throat swabs in 11.5% (41/358) children. There were 82.4% (295/358) abnormal blood count, 41.9% (150/358) low ferritin, 89.9% (322/358) endocrine abnormalities and 20.4% (73/358) various pathologies evaluated by specialists. Conclusions : pathologies affecting our study group are the same affecting other categories of immigrant children, because they often share similar living conditions as orphanage or crowded residencies, low and poor intake of appropriate nutrients for growing ages, leading to malnutrition, vitamin D deficiency, iron deficiency anaemia and intestinal parasitosis. Vaccination records are often not available or reliable. A similar protocol could therefore be helpfully used as an initial management of children coming from a different setting.
背景:根据意大利国家统计局(ISTAT)的数据,2011年,意大利20.7%的外国人口由儿童组成,要么与家人一起来,要么独自来,就像国际收养一样。尽管移民儿童与本土儿童的疾病没有显著差异,但移民儿童与他们以前的生活条件有一些特殊性。方法:在3.5年的时间里,我们采用GLNBI(国家儿童移民组织)诊断辅助方案,对每一位来到我们大学中心的被收养者进行评估,以评估传染病、营养缺乏、免疫状况、肠道寄生虫病或其他病理;这项协议实际上只适用于研究中心。结果:我们评估了来自世界4个不同地区的358名国际被收养者;初次就诊的平均年龄约为5岁。59.2%(212/358)的人认为疫苗接种史记录的健康证明是“有效的”,其中49.5%(105/212)的人有完整的免疫接种小组。QuantiFERON®_TB金管(QTF)检测结果为94.0%(313/333)为阴性,6.0%(20/333)为阳性。HIV、HCV和梅毒检测各血清学阳性0.3%(1/358)。采用免疫酶分析(未通过免疫印迹法证实),囊虫病血清学阳性率为8.9%(32/358),弓形虫病血清学阳性率为13.1%(47/358)。42.7%(153/358)患儿粪便、11.5%(41/358)患儿咽拭子检出阳性。血球计数异常占82.4%(295/358),低铁蛋白占41.9%(150/358),内分泌异常占89.9%(322/358),经专科鉴定的各种病理占20.4%(73/358)。结论:影响本研究组的病理与影响其他类别移民儿童的病理相同,因为他们往往与孤儿院或拥挤的住所有着相似的生活条件,生长年龄所需营养摄入不足,导致营养不良,维生素D缺乏症,缺铁性贫血和肠道寄生虫病。疫苗接种记录往往是不可获得或不可靠的。因此,类似的协议可以作为来自不同环境的儿童的初步管理。
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引用次数: 11
Association between smoking habits and acne vulgaris. A case-control study 吸烟习惯与寻常痤疮之间的关系。病例对照研究
Pub Date : 2012-09-13 DOI: 10.2427/7536
A. Mannocci, L. Semyonov, R. Saulle, N. Skroza, C. Potenza, A. Boccia, G. Torre
Background : acne vulgaris, is one of the most common skin disorder. Previous studies about the role of smoke in the pathogenesis of acne reported contradictory results. The aim of this study was to conduct a case-control study investigating the relationship between tobacco smoking and acne. Methods : a case-control study was performed during the period September 2009 - February 2010. A questionnaire was administrated to each participant, to assess the association acne - smoke. Cases were outpatients of the Dermatologic Ambulatory of the “Fiorini” Hospital, Sapienza University of Rome (Italy). Controls were age and gender-matched to the cases. The ratio cases-controls was 1:2. A univariate and a multiple logistic regression analysis were conducted; Odds Ratio (OR ) and the relative 95% confidence interval (95%CI) were assessed. The statistical significance was set at p < 0.05. Results : crude OR for the association acne - smoke was 7.26 (IC=2.27-23.18); adjusted OR for sex and age was 5.47 (IC=1.67-17.97). Of 93 cases, 6 had a severe grade of acne (6.5%), 19 had an intermediate grade of acne (20.4%), and 68 had a mild grade of acne (73.1%). No one of the smokers had a severe grade of acne, one had an intermediate grade of acne and 11 had mild acne; these differences are not statistically significant. Conclusions : the association between acne and smoke shows an increased risk (OR=7.26) with a statistically significant CI. Moreover, people ≥ 18 years of age have twice the risk compared to persons < 18 years of age (OR=2.31).
背景:寻常性痤疮,是最常见的皮肤病之一。以前关于烟雾在痤疮发病机制中的作用的研究报告了相互矛盾的结果。本研究的目的是进行一项病例对照研究,调查吸烟与痤疮之间的关系。方法:2009年9月- 2010年2月进行病例对照研究。对每个参与者进行问卷调查,以评估痤疮与吸烟的关系。病例为罗马(意大利)Sapienza大学" Fiorini "医院皮肤科门诊患者。对照组的年龄和性别与病例相匹配。病例与对照组的比例为1:2。进行单因素和多元logistic回归分析;评估优势比(OR)和相对95%置信区间(95% ci)。p < 0.05为差异有统计学意义。结果:痤疮-吸烟相关性的粗OR为7.26 (IC=2.27 ~ 23.18);性别和年龄校正OR为5.47 (IC=1.67-17.97)。93例中,重度痤疮6例(6.5%),中度痤疮19例(20.4%),轻度痤疮68例(73.1%)。没有一个吸烟者有严重的痤疮,一个有中度的痤疮,11个有轻度的痤疮;这些差异在统计上并不显著。结论:痤疮和吸烟之间的关联显示风险增加(OR=7.26),具有统计学意义的CI。此外,年龄≥18岁者的风险是年龄< 18岁者的两倍(OR=2.31)。
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引用次数: 2
Right to health of immigrant minors in Italy and Europe 意大利和欧洲移民未成年人的健康权
Pub Date : 2012-09-13 DOI: 10.2427/7526
M. Sisto, L. Gargiullo, O. Ranno, P. Valentini
Undermined survival is usually the reason to migrate: wars, persecutions, famines, natural calamities are just few examples, as well as cultural, economic, social or religious issues. The diversity of these reasons thus correlates with the extreme variability of migrants typologies and their origin countries. Nowadays it has been reached a sufficient stability of the phenomenon, also testified by the growing number of family unities in Italy and all over the Europe, and by the birth of several children in the welcoming country.
破坏生存通常是移民的原因:战争、迫害、饥荒、自然灾害只是几个例子,还有文化、经济、社会或宗教问题。因此,这些原因的多样性与移民类型及其原籍国的极端可变性有关。如今,这一现象已经达到了足够的稳定性,这也证明了意大利和整个欧洲越来越多的家庭团聚,以及在欢迎国家出生的几个孩子。
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引用次数: 1
Work-related health problems among resident immigrant workers in Italy and Spain 意大利和西班牙移民工人的工作相关健康问题
Pub Date : 2012-09-13 DOI: 10.2427/7528
A. Rosano, E. Ronda, F. Benavides, L. Cacciani, G. Baglio, A. Spagnolo
Background : in both Spain and Italy the number of immigrants has strongly increased in the last 20 years, currently representing more than the 10% of workforce in each country. The segregation of immigrants into unskilled or risky jobs brings negative consequences for their health. The objective of this study is to compare prevalence of work-related health problems between immigrants and native workers in Italy and Spain. Methods : data come from the Italian Labour Force Survey (n=65 779) and Spanish Working Conditions Survey (n=11 019), both conducted in 2007. We analyzed merged datasets to evaluate whether interviewees, both natives and migrants, judge their health being affected by their work conditions and, if so, which specific diseases. For migrants, we considered those coming from countries with a value of the Human Development Index lower than 0.85. Logistic regression models were used, including gender, age, and education as adjusting factors. Results : migrants reported skin diseases (Mantel-Haenszel pooled OR=1.49; 95%CI: 0.59-3.74) and musculoskeletal problems among those employed in agricultural sector (Mantel-Haenszel pooled OR=1.16; 95%CI: 0.69-1.96) more frequently than natives; country-specific analysis showed higher risks of musculoskeletal problems among migrants compared to the non-migrant population in Italy (OR=1.17; 95% CI: 0.48-1.59) and of respiratory problems in Spain (OR=2.02; 95%CI: 1.02-4.0). In both countries the risk of psychological stress was predominant among national workers. Conclusions : this collaborative study allows to strength the evidence concerning the health of migrant workers in Southern European countries.
背景:在过去的20年里,西班牙和意大利的移民数量都有了显著的增长,目前占到两国劳动力的10%以上。将移民隔离在非技术性或高风险的工作岗位上,给他们的健康带来负面影响。本研究的目的是比较意大利和西班牙移民和本地工人之间与工作有关的健康问题的患病率。方法:数据来自意大利劳动力调查(n= 65779)和西班牙工作条件调查(n= 11019),均于2007年进行。我们分析了合并的数据集,以评估受访者(无论是本地人还是移民)是否判断自己的健康受到工作条件的影响,如果是的话,是哪种具体疾病。对于移民,我们考虑了那些来自人类发展指数低于0.85的国家的移民。采用Logistic回归模型,以性别、年龄、教育程度为调整因素。结果:移民报告皮肤疾病(Mantel-Haenszel合并OR=1.49;95%CI: 0.59-3.74)和肌肉骨骼问题(Mantel-Haenszel合并OR=1.16;95%CI: 0.69-1.96)比本地人更频繁;具体国家的分析显示,与意大利的非移民人口相比,移民中肌肉骨骼问题的风险更高(OR=1.17;95% CI: 0.48-1.59)和西班牙呼吸系统疾病(OR=2.02;95%置信区间:1.02—-4.0)。在这两个国家,心理压力的风险在本国工人中占主导地位。结论:这项合作研究加强了有关南欧国家移徙工人健康的证据。
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引用次数: 13
Midwives unable to overcome language barriers in prenatal care 助产士在产前护理中无法克服语言障碍
Pub Date : 2012-09-13 DOI: 10.2427/7531
M. Fransen, H. Wildschut, J. Mackenbach, E. Steegers, M. Essink‐bot
Background : the present study aims to explore to what extent midwives experience barriers in providing information about prenatal screening for Down syndrome to women from diverse ethnic backgrounds, and to assess their competences to overcome these barriers. Methods : midwives from 24 Dutch midwifery practices in Rotterdam completed a structured webbased questionnaire (n=57). Data were obtained on perceived ethnic-related differences and barriers in providing information on prenatal screening, preparedness to provide cultural competent care, and the use of translated materials and professional translators. A group interview was conducted to further explore the results emerging from the questionnaire (n=23). Results : almost all midwives (95%) experienced barriers in informing women from non-Western ethnic backgrounds about prenatal screening. Midwives especially felt incompetent to provide information to pregnant women that hardly speak and understand Dutch. In total 58% of the midwives reported that they never used translated information materials and 88% never used professional interpreters in providing information on prenatal screening. The main reasons for this underutilization were unawareness of the availability of translated materials and unfamiliarity with the use of professional interpreters. Conclusions : although language barriers were reported to be the main difficulty in providing cultural competent care to patients from diverse ethnic backgrounds, only a minority of the midwives used translated materials or professional interpreters. In order to enable all pregnant women to make an informed decision whether or not to participate in prenatal screening, midwives’ competences to address language barriers should be increased.
背景:本研究旨在探讨助产士在向不同种族背景的妇女提供唐氏综合症产前筛查信息方面遇到的障碍程度,并评估她们克服这些障碍的能力。方法:来自鹿特丹24家荷兰助产机构的助产士完成了一份结构化的基于网络的问卷调查(n=57)。在提供产前筛查信息、准备提供符合文化要求的护理以及使用翻译材料和专业翻译人员方面,获得了与种族有关的感知差异和障碍的数据。通过小组访谈进一步探讨问卷调查的结果(n=23)。结果:几乎所有的助产士(95%)在告知非西方种族背景的妇女产前筛查时遇到障碍。助产士尤其感到没有能力向几乎不会说也听不懂荷兰语的孕妇提供信息。总共58%的助产士报告说,他们从未使用过翻译的信息材料,88%的助产士从未使用过专业口译员提供产前筛查信息。这种利用不足的主要原因是不知道有翻译材料和不熟悉使用专业口译员。结论:尽管据报道,语言障碍是向来自不同种族背景的患者提供文化合格护理的主要困难,但只有少数助产士使用翻译材料或专业口译员。为了使所有孕妇都能在知情的情况下决定是否参加产前筛查,助产士应对语言障碍的能力应得到提高。
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引用次数: 10
期刊
Italian journal of public health
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