Pub Date : 2026-01-31DOI: 10.1016/j.biotechadv.2026.108813
Robin B. Gasser
{"title":"Biotechnology advances and the parasitology paradigm: From genomes to multi-omics and translation","authors":"Robin B. Gasser","doi":"10.1016/j.biotechadv.2026.108813","DOIUrl":"https://doi.org/10.1016/j.biotechadv.2026.108813","url":null,"abstract":"","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"74 1","pages":""},"PeriodicalIF":16.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1016/j.biotechadv.2026.108817
Mruthula Rammohan, Kevin V. Solomon
{"title":"Strategies for controlled assembly of rod-shaped viral particles","authors":"Mruthula Rammohan, Kevin V. Solomon","doi":"10.1016/j.biotechadv.2026.108817","DOIUrl":"https://doi.org/10.1016/j.biotechadv.2026.108817","url":null,"abstract":"","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"7 1","pages":""},"PeriodicalIF":16.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.biotechadv.2026.108816
Duodong Wang, Na Wang, Houhui Song, Chenggang Xu
{"title":"Corrigendum to “Precise control of transcriptional stoichiometry in bacteria: From mechanisms to synthetic biology applications” [Biotechnology Advances 86 (2026) 108748]","authors":"Duodong Wang, Na Wang, Houhui Song, Chenggang Xu","doi":"10.1016/j.biotechadv.2026.108816","DOIUrl":"https://doi.org/10.1016/j.biotechadv.2026.108816","url":null,"abstract":"","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"43 1","pages":""},"PeriodicalIF":16.0,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.biotechadv.2026.108812
Xuenan Shui , Chen Deng , Xiaoman He , Daolun Liang , Dekui Shen , Wangbiao Guo , Wenlei Zhu , Xue Ning , Richen Lin
Semi-artificial photosynthesis, integrating biocatalysts with photosensitive materials to enable self-photosensitization in non-photosynthetic microorganisms, is a rapidly evolving interdisciplinary field for solar-driven energy and chemical production using air, water, and sunlight. However, the efficiency of such constructed biocatalysts is often impeded by the limited biocompatibility, prevalent biotoxicity, and narrow spectral response associated with photosensitive materials. Quantum dots (QDs), zero-dimensional crystals, exhibit favorable photoexcitation properties and enhanced biocompatibility, providing essential reducing equivalents for microbial metabolisms. This review examines recent advances in semi-artificial photosynthesis, focusing on the self-assembly of microorganisms in conjunction with QDs. It highlights the biocompatible, directional design of QDs and explores the underlying mechanisms of electron and energy transfer within the microbe-QDs complexes. By leveraging the synergies of solar absorption and biocatalytic activity, this review discusses the future trajectory and potential improvements in semi-artificial photosynthesis, offering a paradigm-shifting approach to sustainable solar energy utilization. The solar-powered QDs-biocatalyst biohybrids for semi-artificial photosynthesis are projected to emerge as a transformative technology in advanced energy production.
{"title":"Solar-powered quantum dot-biocatalyst biohybrids for semi-artificial photosynthesis: Advances in interfacial design and energy-mass transfer optimisation","authors":"Xuenan Shui , Chen Deng , Xiaoman He , Daolun Liang , Dekui Shen , Wangbiao Guo , Wenlei Zhu , Xue Ning , Richen Lin","doi":"10.1016/j.biotechadv.2026.108812","DOIUrl":"10.1016/j.biotechadv.2026.108812","url":null,"abstract":"<div><div>Semi-artificial photosynthesis, integrating biocatalysts with photosensitive materials to enable self-photosensitization in non-photosynthetic microorganisms, is a rapidly evolving interdisciplinary field for solar-driven energy and chemical production using air, water, and sunlight. However, the efficiency of such constructed biocatalysts is often impeded by the limited biocompatibility, prevalent biotoxicity, and narrow spectral response associated with photosensitive materials. Quantum dots (QDs), zero-dimensional crystals, exhibit favorable photoexcitation properties and enhanced biocompatibility, providing essential reducing equivalents for microbial metabolisms. This review examines recent advances in semi-artificial photosynthesis, focusing on the self-assembly of microorganisms in conjunction with QDs. It highlights the biocompatible, directional design of QDs and explores the underlying mechanisms of electron and energy transfer within the microbe-QDs complexes. By leveraging the synergies of solar absorption and biocatalytic activity, this review discusses the future trajectory and potential improvements in semi-artificial photosynthesis, offering a paradigm-shifting approach to sustainable solar energy utilization. The solar-powered QDs-biocatalyst biohybrids for semi-artificial photosynthesis are projected to emerge as a transformative technology in advanced energy production.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108812"},"PeriodicalIF":12.5,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1016/j.biotechadv.2026.108810
Shu-Tong Wu , Xiao-Chuan Zheng , Chuan Chen , Zhong-Fang Sun , Kai-Kai Wu , De-Feng Xing , Shan-Shan Yang , Ai-Jie Wang , Nan-Qi Ren , Lei Zhao
The bioconversion of carbon dioxide (CO2) into polyhydroxyalkanoates (PHAs) represents a transformative paradigm at the nexus of climate mitigation and sustainable manufacturing, offering a route to valorize a greenhouse gas (GHG) liability into high-value, biodegradable polymers. This critical review provides a systematic analysis of the technological landscape for CO2-to-PHA bioconversion, comparing the two dominant strategies: direct, single-organism autotrophic routes and modular, two-step hybrid systems that couple abiotic CO2 reduction with microbial fermentation. While direct autotrophic processes offer conceptual simplicity, they exhibit a wide performance gap: photoautotrophs are typically constrained by low volumetric productivities (<10 mg L−1 h−1) due to light limitation, whereas optimized chemoautotrophic systems (e.g., Cupriavidus necator) can achieve significantly higher rates of up to 1.55 g L−1 h−1. In contrast, two-step hybrid systems show promise for modularity by decoupling CO2 activation from biosynthesis. However, current integrated platforms generally demonstrate productivities in the milligram range (e.g., <25 mg L−1 h−1). Critical bottlenecks, specifically inefficient gas-liquid mass transfer (low kLa), catalyst instability (<100 h lifetime), and the high energy penalty of downstream separation, persist across all platforms. Currently keeping production costs ($3–8/kg) well above the economic threshold. The path forward requires a strategic roadmap focused on three pillars: dynamic metabolic control via synthetic biology, process intensification using advanced reactor engineering, and holistic system integration. The successful convergence of these disciplines, supported by robust techno-economic frameworks and life-cycle assessments, is critical to transforming CO2-to-PHA bioconversion from a promising concept into a cornerstone technology for the circular bioeconomy.
{"title":"Biomanufacturing polyhydroxyalkanoates from CO2: A critical review of advances, challenges, and solutions for autotrophic and hybrid systems","authors":"Shu-Tong Wu , Xiao-Chuan Zheng , Chuan Chen , Zhong-Fang Sun , Kai-Kai Wu , De-Feng Xing , Shan-Shan Yang , Ai-Jie Wang , Nan-Qi Ren , Lei Zhao","doi":"10.1016/j.biotechadv.2026.108810","DOIUrl":"10.1016/j.biotechadv.2026.108810","url":null,"abstract":"<div><div>The bioconversion of carbon dioxide (CO<sub>2</sub>) into polyhydroxyalkanoates (PHAs) represents a transformative paradigm at the nexus of climate mitigation and sustainable manufacturing, offering a route to valorize a greenhouse gas (GHG) liability into high-value, biodegradable polymers. This critical review provides a systematic analysis of the technological landscape for CO<sub>2</sub>-to-PHA bioconversion, comparing the two dominant strategies: direct, single-organism autotrophic routes and modular, two-step hybrid systems that couple abiotic CO<sub>2</sub> reduction with microbial fermentation. While direct autotrophic processes offer conceptual simplicity, they exhibit a wide performance gap: photoautotrophs are typically constrained by low volumetric productivities (<10 mg L<sup>−1</sup> h<sup>−1</sup>) due to light limitation, whereas optimized chemoautotrophic systems (e.g., <em>Cupriavidus necator</em>) can achieve significantly higher rates of up to 1.55 g L<sup>−1</sup> h<sup>−1</sup>. In contrast, two-step hybrid systems show promise for modularity by decoupling CO<sub>2</sub> activation from biosynthesis. However, current integrated platforms generally demonstrate productivities in the milligram range (e.g., <25 mg L<sup>−1</sup> h<sup>−1</sup>). Critical bottlenecks, specifically inefficient gas-liquid mass transfer (low <em>k</em><sub>L</sub><em>a</em>), catalyst instability (<100 h lifetime), and the high energy penalty of downstream separation, persist across all platforms. Currently keeping production costs ($3–8/kg) well above the economic threshold. The path forward requires a strategic roadmap focused on three pillars: dynamic metabolic control via synthetic biology, process intensification using advanced reactor engineering, and holistic system integration. The successful convergence of these disciplines, supported by robust techno-economic frameworks and life-cycle assessments, is critical to transforming CO<sub>2</sub>-to-PHA bioconversion from a promising concept into a cornerstone technology for the circular bioeconomy.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108810"},"PeriodicalIF":12.5,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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