Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.08.235
E. Kose, N. Yasuno
The relationship between polypharmacy and malnutrition is based on several mechanisms. Long-term abuse of multiple drugs results in anorexia, which generally causes minor or more serious impairment of the digestive tract. Conversely, malnutrition often decreases the biological availability of drugs and changes their pharmacokinetic and pharmacodynamic properties. Polypharmacy and malnutrition are significant geriatric syndromes that need to be assessed and treated in all older adults; furthermore, they must be evaluated together rather than separately. Practitioners should be aware of the potential impact of individual medication classes as well as extreme polypharmacy on nutritional status and work to reduce the impact through targeted interventions.
{"title":"Drug-Induced Nutrient Deficiencies Among Older Adults","authors":"E. Kose, N. Yasuno","doi":"10.35248/2329-8847.20.08.235","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.235","url":null,"abstract":"The relationship between polypharmacy and malnutrition is based on several mechanisms. Long-term abuse of multiple drugs results in anorexia, which generally causes minor or more serious impairment of the digestive tract. Conversely, malnutrition often decreases the biological availability of drugs and changes their pharmacokinetic and pharmacodynamic properties. Polypharmacy and malnutrition are significant geriatric syndromes that need to be assessed and treated in all older adults; furthermore, they must be evaluated together rather than separately. Practitioners should be aware of the potential impact of individual medication classes as well as extreme polypharmacy on nutritional status and work to reduce the impact through targeted interventions.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70003680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.8.E225
Rajajeyakumar Manivel
EDITORIAL Aging Science deals with the stages that an individual face during late phase of his life. Journal of Aging Science is an open access peer review publisher which completed 8 years of publication. During this period we achieved in disclosing all the quality articles to the public where we can help researchers, scientists, professors etc. in updating the information every now and then. During the year 2019, we have published articles related to sedentary behavior, Centenarians, Older adults memory, bereavement in geriatrics, frailty among surgical patients and many more. The research article of Volume 7 issue 2 of Karlin NJ, et al. developed a typology towards understanding the cultural uniformity and components relayted aging which resulted in developing aging perception measure (questionnaire). This helps in investigating aging process world wide [1]. The review article of Scher LML, et al. summarized that there is an association between physical disability and sedenatry time in older adults [2].
编辑老化科学处理的阶段，一个人面对在他的生命的后期阶段。Journal of Aging Science是一家开放获取的同行评审出版商，已经出版了8年。在此期间，我们实现了向公众披露所有优质文章，我们可以帮助研究人员，科学家，教授等随时更新信息。在2019年，我们发表了有关久坐行为、百岁老人、老年人记忆、老年病学丧亲之痛、手术患者虚弱等方面的文章。Karlin NJ等人的第7卷第2期的研究文章开发了一种类型学来理解与衰老相关的文化统一性和组成部分，从而开发了衰老感知测量(问卷)。这有助于研究世界范围内的老化过程。Scher LML等人的综述文章总结了老年人身体残疾与久坐时间之间的关联[10]。
{"title":"Aging Science: New Stage of Growing Old","authors":"Rajajeyakumar Manivel","doi":"10.35248/2329-8847.20.8.E225","DOIUrl":"https://doi.org/10.35248/2329-8847.20.8.E225","url":null,"abstract":"EDITORIAL Aging Science deals with the stages that an individual face during late phase of his life. Journal of Aging Science is an open access peer review publisher which completed 8 years of publication. During this period we achieved in disclosing all the quality articles to the public where we can help researchers, scientists, professors etc. in updating the information every now and then. During the year 2019, we have published articles related to sedentary behavior, Centenarians, Older adults memory, bereavement in geriatrics, frailty among surgical patients and many more. The research article of Volume 7 issue 2 of Karlin NJ, et al. developed a typology towards understanding the cultural uniformity and components relayted aging which resulted in developing aging perception measure (questionnaire). This helps in investigating aging process world wide [1]. The review article of Scher LML, et al. summarized that there is an association between physical disability and sedenatry time in older adults [2].","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70004214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging Science deals with the stages that an individual face during late phase of his life. Journal of Aging Science is an open access peer review publisher which completed 8 years of publication. During this period we achieved in disclosing all the quality articles to the public where we can help researchers, scientists, professors etc. in updating the information every now and then. During the year 2019, we have published articles related to sedentary behavior, Centenarians, Older adults memory, bereavement in geriatrics, frailty among surgical patients and many more. In 2020, we have published nearly 2 issues containing 7-8 articles.
衰老科学研究的是一个人在他生命的晚期所面临的阶段。Journal of Aging Science是一家开放获取的同行评审出版商，已经出版了8年。在此期间，我们实现了向公众披露所有优质文章，我们可以帮助研究人员，科学家，教授等随时更新信息。在2019年，我们发表了有关久坐行为、百岁老人、老年人记忆、老年病学丧亲之痛、手术患者虚弱等方面的文章。2020年共出版近2期，刊载文章7-8篇。
{"title":"Aging: Ongoing Process of Life","authors":"Rajajeyakumar Manivel","doi":"10.35248/2329","DOIUrl":"https://doi.org/10.35248/2329","url":null,"abstract":"Aging Science deals with the stages that an individual face during late phase of his life. Journal of Aging Science is an open access peer review publisher which completed 8 years of publication. During this period we achieved in disclosing all the quality articles to the public where we can help researchers, scientists, professors etc. in updating the information every now and then. During the year 2019, we have published articles related to sedentary behavior, Centenarians, Older adults memory, bereavement in geriatrics, frailty among surgical patients and many more. In 2020, we have published nearly 2 issues containing 7-8 articles.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69998462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.08.227
E. Evangelou
The promotion of healthy and active ageing is nowadays a global challenge. This project explored several QoL domains of men and women over 60 yrs old, residents of Southern Attica, users of the Local Open Care Centre (LOCC) for older adults. It examined as well, the views of care staff about what are the wider determinants that affect QoL of older adults. Main objective of the study was to investigate the impact of the LOCC activities to the users’ well-being, as well as, to explore several life domains, such as, family and social relations, living conditions, finance, health status and leisure and their level of satisfaction from these domains. Results indicated that the views of the professionals and those of the LOCC users were compatible, in terms of life domains which have a positive impact to older people ’ s well-being. This commentary is part of a bigger project which aims at examining the ways of responding to local citizens’ complex needs, as they get older, so that they can enjoy a longer and healthier life.
{"title":"Exploring the Views of Care Staff and of the Members of a Local Open Care Centre About Quality of Life (QoL) and Active Healthy Ageing","authors":"E. Evangelou","doi":"10.35248/2329-8847.20.08.227","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.227","url":null,"abstract":"The promotion of healthy and active ageing is nowadays a global challenge. This project explored several QoL domains of men and women over 60 yrs old, residents of Southern Attica, users of the Local Open Care Centre (LOCC) for older adults. It examined as well, the views of care staff about what are the wider determinants that affect QoL of older adults. Main objective of the study was to investigate the impact of the LOCC activities to the users’ well-being, as well as, to explore several life domains, such as, family and social relations, living conditions, finance, health status and leisure and their level of satisfaction from these domains. Results indicated that the views of the professionals and those of the LOCC users were compatible, in terms of life domains which have a positive impact to older people ’ s well-being. This commentary is part of a bigger project which aims at examining the ways of responding to local citizens’ complex needs, as they get older, so that they can enjoy a longer and healthier life.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70002999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.08.221
Ueberberg Bianca, Assion Hans-Joerg
Schizoaffective Disorder (SAD) is a mental disorder characterized by symptoms of schizophrenia and affective disorder like depression and/or mania, which occur simultaneously or alternately. In the international classification of mental disorders, ICD-10, it is subsumed under the spectrum of schizophrenia, schizotypal and delusional disorders. However, the available research results do not allow a final decision whether SAD is more appropriate classified in the affective disorder chapter [1].
{"title":"Schizoaffective Disorder: A Challenge","authors":"Ueberberg Bianca, Assion Hans-Joerg","doi":"10.35248/2329-8847.20.08.221","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.221","url":null,"abstract":"Schizoaffective Disorder (SAD) is a mental disorder characterized by symptoms of schizophrenia and affective disorder like depression and/or mania, which occur simultaneously or alternately. In the international classification of mental disorders, ICD-10, it is subsumed under the spectrum of schizophrenia, schizotypal and delusional disorders. However, the available research results do not allow a final decision whether SAD is more appropriate classified in the affective disorder chapter [1].","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70002783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.08.233
Mehdi Kushkestani, Mohsen Parvani, Ki, okhtMoradi, M. Moghadassi
Background: The last studies have shown that aging is associated with an increase in the risk of malnutrition and related complications. The aim of this study was to investigate the relationship between malnutrition and cognitive function, tiredness and sleep quality in the elderly living in nursing home. Methods: The subjects of this study were 119 elderly people over the age of 65 living in nursing homes in Tehran. The demographic characteristics of the subjects were collected and recorded. Then, body composition and anthropometric indices including weight, body mass index [BMI], height and calf circumferences [CC], waist circumferences [WC] and hip circumferences were measured using a digital scale of OMRON and meter tape. nutritional status, cognitive function, sleep quality and level of tiredness were measured by Mini Nutritional Status, Mini-Mental State Examination, Pittsburgh Sleep Quality Index and FACIT-Fatigue scale, respectively. Results: The results of statistical analysis of the data showed a positive relationship between malnutrition with dementia [p<0.024],fatigue [p<0.000] and sleep quality [p<0.008]. Conclusion: Taken together, the use of strategies to improve the nutritional status of the elderly in nursing homes can play an important role in preventing the symptoms of geriatric syndrome and increasing the level of health in the elderly.
背景:最近的研究表明，衰老与营养不良及相关并发症的风险增加有关。摘要本研究旨在探讨营养不良与老年人认知功能、疲劳及睡眠质量的关系。方法:本研究的对象为119名居住在德黑兰养老院的65岁以上老年人。收集并记录受试者的人口统计学特征。然后，使用欧姆龙数字秤和米卷尺测量身体组成和人体测量指标，包括体重、体重指数(BMI)、身高和小腿围(CC)、腰围(WC)和臀围(臀围)。采用Mini nutrition status、Mini mental State Examination、Pittsburgh sleep quality Index和FACIT-Fatigue量表分别测量营养状况、认知功能、睡眠质量和疲劳程度。结果:数据统计分析结果显示，营养不良与痴呆[p<0.024]、疲劳[p<0.000]、睡眠质量[p<0.008]呈正相关。结论:综上所述，利用策略改善养老院老年人的营养状况，对预防老年综合征的症状，提高老年人的健康水平具有重要作用。
{"title":"Malnutrition is Associated with Cognitive Function, Tiredness and Sleep Quality in Elderly Living Nursing Home","authors":"Mehdi Kushkestani, Mohsen Parvani, Ki, okhtMoradi, M. Moghadassi","doi":"10.35248/2329-8847.20.08.233","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.233","url":null,"abstract":"Background: The last studies have shown that aging is associated with an increase in the risk of malnutrition and related complications. The aim of this study was to investigate the relationship between malnutrition and cognitive function, tiredness and sleep quality in the elderly living in nursing home. Methods: The subjects of this study were 119 elderly people over the age of 65 living in nursing homes in Tehran. The demographic characteristics of the subjects were collected and recorded. Then, body composition and anthropometric indices including weight, body mass index [BMI], height and calf circumferences [CC], waist circumferences [WC] and hip circumferences were measured using a digital scale of OMRON and meter tape. nutritional status, cognitive function, sleep quality and level of tiredness were measured by Mini Nutritional Status, Mini-Mental State Examination, Pittsburgh Sleep Quality Index and FACIT-Fatigue scale, respectively. Results: The results of statistical analysis of the data showed a positive relationship between malnutrition with dementia [p<0.024],fatigue [p<0.000] and sleep quality [p<0.008]. Conclusion: Taken together, the use of strategies to improve the nutritional status of the elderly in nursing homes can play an important role in preventing the symptoms of geriatric syndrome and increasing the level of health in the elderly.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70003603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.08.228
Zhiliang Huang, Yu Gao, Dianchen Hua
Objective: To explore the relationship between TGF-beta signaling pathway and atrial fibrillation in patients with mitral valve disease, and reveal the mechanism of TGF-beta signaling pathway in development of atrial fibrillation. Methods: Firstly, the fibrosis extent of right atrial appendage tissues were tested by Masson’s trichrome staining. Secondly, the protein expression of TGF-beta1, TGF-beta RI, RII, RIII, P-Smad2/3, Smad2/3, Smad4, Smad7, TAK1, p38, ATF-2 were tested by Western blot. Results: There were significant difference between atrial fibrillation group and control group in fibrosis extent and the diameter of left atria (p0.05). The patients with atrial fibrillation are associated with the more serious fibrosis and larger diameter of left atria. For further study, the Western bolt results reveal that protein expression of TGF-beta1 and Smad4 were significant higher in atrial fibrillation and sever fibrosis group, other factors were no difference between trial and control group. Conclusion: There are severing atrial fibrosis in atrial fibrillation patients with mitral valve diseases. The over expression of TGF-beta1 and Smad4 maybe is an important reason that induces atrial fibrosis in atrial fibrillation, and the atrial fibrosis appears to play a role in the development of atrial fibrillation. Fibrosis response by TGF-beta1 initiating maybe only depends on mutations of the TGF-beta Smad signaling pathway.
{"title":"TGF-Beta Signaling Pathways in the Study of Expression in Patients with Atrial Fibrillation Atrial Tissue","authors":"Zhiliang Huang, Yu Gao, Dianchen Hua","doi":"10.35248/2329-8847.20.08.228","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.228","url":null,"abstract":"Objective: To explore the relationship between TGF-beta signaling pathway and atrial fibrillation in patients with mitral valve disease, and reveal the mechanism of TGF-beta signaling pathway in development of atrial fibrillation. Methods: Firstly, the fibrosis extent of right atrial appendage tissues were tested by Masson’s trichrome staining. Secondly, the protein expression of TGF-beta1, TGF-beta RI, RII, RIII, P-Smad2/3, Smad2/3, Smad4, Smad7, TAK1, p38, ATF-2 were tested by Western blot. Results: There were significant difference between atrial fibrillation group and control group in fibrosis extent and the diameter of left atria (p0.05). The patients with atrial fibrillation are associated with the more serious fibrosis and larger diameter of left atria. For further study, the Western bolt results reveal that protein expression of TGF-beta1 and Smad4 were significant higher in atrial fibrillation and sever fibrosis group, other factors were no difference between trial and control group. Conclusion: There are severing atrial fibrosis in atrial fibrillation patients with mitral valve diseases. The over expression of TGF-beta1 and Smad4 maybe is an important reason that induces atrial fibrosis in atrial fibrillation, and the atrial fibrosis appears to play a role in the development of atrial fibrillation. Fibrosis response by TGF-beta1 initiating maybe only depends on mutations of the TGF-beta Smad signaling pathway.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"42 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70002796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.08.231
I. Sindhuja
DESCRIPTION Aging is a physiological deterioration in physiological functions that results in age related frailty, disability and disease leading ultimately to death. Aging causes increase in age specific death rate. Such aging process is widespread among all species. Some organisms like Hydra showed no signs of aging at all. Understanding of aging tells us about why and how aging evolved.Unknowing view is that aging is driven by genetic programme directly leading to decline of the body. Advantages of the aging is that it worn outs aged individuals from the competing resources with their progeny. Firstly evidence from natural populations proves that aging is a significant contribution to mortality in the wild. So with no doubts an individual lives long to experience senescence more vulnerable to predators.Wild populations indicate that mortality during the early and middle periods of life is usually so that only a small fraction of individuals survives loud enough
{"title":"Age Related Physiological and Psychological Behavior","authors":"I. Sindhuja","doi":"10.35248/2329-8847.20.08.231","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.231","url":null,"abstract":"DESCRIPTION Aging is a physiological deterioration in physiological functions that results in age related frailty, disability and disease leading ultimately to death. Aging causes increase in age specific death rate. Such aging process is widespread among all species. Some organisms like Hydra showed no signs of aging at all. Understanding of aging tells us about why and how aging evolved.Unknowing view is that aging is driven by genetic programme directly leading to decline of the body. Advantages of the aging is that it worn outs aged individuals from the competing resources with their progeny. Firstly evidence from natural populations proves that aging is a significant contribution to mortality in the wild. So with no doubts an individual lives long to experience senescence more vulnerable to predators.Wild populations indicate that mortality during the early and middle periods of life is usually so that only a small fraction of individuals survives loud enough","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70003433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.08.223
M. Hachisu, M. Obayashi, M. Kogo, K. Ihara
The elderly population of people aged > 65 years is rapidly growing up in developed countries, including Japan, and becoming a burden by increasing caregiving and social security costs. Prolonging a healthy life span without caregiver help would reduce the social burden. Frailty in elderly people can cause accidental falls causing them to be bed ridden, but constant exercise could help prevent such accidents. Various exercises enhance the synthesis and release of neurotrophic factors such as IGF-1 and BDNF; these neurotrophic factors enhance neuronal growth and survival in the brain prevent muscle atrophy and sometimes contribute to muscle hypertrophy in elderly people. These exercise-induced neurotrophic factors can thereby help prevent the lowering of cognitive performance, processing speed and mood in elderly people including those with Alzheimer’s disease or Parkinson’s disease. In this review, we emphasize that IGF-1 and BDNF work as anabolic growth factors for skeletal muscle, play a role in the neurogenesis, synaptogenesis, and neuronal survival in the brain, ameliorate cognition, and stabilize psychiatric mood. IGF-1, further, has activities in the elimination of amyloid-β protein by activating protein transportation at the choroid plexus and angiogenesis acting on brain vessels. Thus, elderly people are recommended to exercise regularly for their health and avoid the condition of frailty.
{"title":"Psychosomatic Health in Elderly People for Preventing Frailty: The role of IGF-1 and BDNF in the Muscle and the Brain","authors":"M. Hachisu, M. Obayashi, M. Kogo, K. Ihara","doi":"10.35248/2329-8847.20.08.223","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.223","url":null,"abstract":"The elderly population of people aged > 65 years is rapidly growing up in developed countries, including Japan, and becoming a burden by increasing caregiving and social security costs. Prolonging a healthy life span without caregiver help would reduce the social burden. Frailty in elderly people can cause accidental falls causing them to be bed ridden, but constant exercise could help prevent such accidents. Various exercises enhance the synthesis and release of neurotrophic factors such as IGF-1 and BDNF; these neurotrophic factors enhance neuronal growth and survival in the brain prevent muscle atrophy and sometimes contribute to muscle hypertrophy in elderly people. These exercise-induced neurotrophic factors can thereby help prevent the lowering of cognitive performance, processing speed and mood in elderly people including those with Alzheimer’s disease or Parkinson’s disease. In this review, we emphasize that IGF-1 and BDNF work as anabolic growth factors for skeletal muscle, play a role in the neurogenesis, synaptogenesis, and neuronal survival in the brain, ameliorate cognition, and stabilize psychiatric mood. IGF-1, further, has activities in the elimination of amyloid-β protein by activating protein transportation at the choroid plexus and angiogenesis acting on brain vessels. Thus, elderly people are recommended to exercise regularly for their health and avoid the condition of frailty.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70002846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2329-8847.20.08.229
Andrei Buciuta, Vinasi Rc, H. Coman
Introduction: Alzheimer's Dementia (AD) is a neurodegenerative disease characterized by progressive cognitive decline. Neuropsychiatric symptoms (NPS) are frequently described in AD. Among the non-cognitive symptoms that can occur in AD, depression is the most common one. Objective: The aim was to review published studies in order to examine the efficacy and safety of antidepressant medication for depression in AD. Methods: An electronic database search was performed using the keywords: ” antidepressant ” , “ randomized controlled trial (RCT)”, “depression”, “dementia”, ”Alzheimer’s disease”. For the evaluation of efficacy, the reduction of scores on the evaluation scales of depression and the rate of response or remission were used and for the safety evaluation the rate of dropout and the rate of adverse effects were considered. The effect of antidepressant therapy on cognitive performances was also tracked. Results: According to inclusion criteria, 14 RCT studies that aimed at assessing the efficacy and safety of an antidepressant in the treatment of AD associated depression have been selected, as well as 6 additional studies that use two or more antidepressants. The results show a debatable efficacy of these treatments. Among the included antidepressants, selective serotonin reuptake inhibitors (SSRIs) have proven to be most tolerated and without negative effects on cognition. Conclusions: The available evidence does not provide sufficient support to uphold the efficacy and safety of antidepressant in the treatment of AD associated depression
{"title":"Antidepressant Treatment for Depression in Alzheimerandrsquo;s Dementia: Systematic Review Article","authors":"Andrei Buciuta, Vinasi Rc, H. Coman","doi":"10.35248/2329-8847.20.08.229","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.229","url":null,"abstract":"Introduction: Alzheimer's Dementia (AD) is a neurodegenerative disease characterized by progressive cognitive decline. Neuropsychiatric symptoms (NPS) are frequently described in AD. Among the non-cognitive symptoms that can occur in AD, depression is the most common one. Objective: The aim was to review published studies in order to examine the efficacy and safety of antidepressant medication for depression in AD. Methods: An electronic database search was performed using the keywords: ” antidepressant ” , “ randomized controlled trial (RCT)”, “depression”, “dementia”, ”Alzheimer’s disease”. For the evaluation of efficacy, the reduction of scores on the evaluation scales of depression and the rate of response or remission were used and for the safety evaluation the rate of dropout and the rate of adverse effects were considered. The effect of antidepressant therapy on cognitive performances was also tracked. Results: According to inclusion criteria, 14 RCT studies that aimed at assessing the efficacy and safety of an antidepressant in the treatment of AD associated depression have been selected, as well as 6 additional studies that use two or more antidepressants. The results show a debatable efficacy of these treatments. Among the included antidepressants, selective serotonin reuptake inhibitors (SSRIs) have proven to be most tolerated and without negative effects on cognition. Conclusions: The available evidence does not provide sufficient support to uphold the efficacy and safety of antidepressant in the treatment of AD associated depression","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70002950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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