Pub Date : 2016-12-09DOI: 10.15406/MOJI.2016.04.00139
C. Valverde, Karen López Miguel, J. A. Sánchez-Villanueva, Alej, R. Lambert, Tania Carmenate Portilla, María del Carmen Arango Prado
Background: Ovarian carcinoma (OC) is one of the most severe and lethal cancers in women. Regulatory T (Treg) cells may participate in mediating a suppressive microenvironment in tumor tissue and contribute to tumor evasion from immune response. Specifically, some studies have indicated that Treg cell infiltration in malignant ascites and peripheral blood has been associated with poor clinical outcome. Methods: The number of CD4+, CD25+, forkhead box p3+ (Foxp3+) lymphocytes was assessed via flow cytometry in ascites and peripheral blood from 24 women with epithelial ovarian cancer (EOC). Overall survival was associated with Treg levels. Results: The study indicated an increase in the Treg cell subset from peripheral blood of EOC patients compared with those in healthy controls. Treg infiltration in ascites was higher than in blood into EOC patients. The patients with high infiltration of Treg in blood revealed less overall survival compared to a counterpart with normal levels of Treg. Regarding the association between patients with increased levels of Treg in ascites with overall survival there was no disadvantage found, compared to ascites from patients with normal levels of Treg. Conclusion: Study suggests that Treg lymphocytes were increased in ascites and peripheral blood in EOC patients and could be associated with diminished overall survival, via impairment antitumor immune response.
{"title":"Infiltration of Regulatory T Lymphocytes Impair Clinical Outcome in Ovarian Cancer Patients","authors":"C. Valverde, Karen López Miguel, J. A. Sánchez-Villanueva, Alej, R. Lambert, Tania Carmenate Portilla, María del Carmen Arango Prado","doi":"10.15406/MOJI.2016.04.00139","DOIUrl":"https://doi.org/10.15406/MOJI.2016.04.00139","url":null,"abstract":"Background: Ovarian carcinoma (OC) is one of the most severe and lethal cancers in women. Regulatory T (Treg) cells may participate in mediating a suppressive microenvironment in tumor tissue and contribute to tumor evasion from immune response. Specifically, some studies have indicated that Treg cell infiltration in malignant ascites and peripheral blood has been associated with poor clinical outcome. \u0000 Methods: The number of CD4+, CD25+, forkhead box p3+ (Foxp3+) lymphocytes was assessed via flow cytometry in ascites and peripheral blood from 24 women with epithelial ovarian cancer (EOC). Overall survival was associated with Treg levels. \u0000 Results: The study indicated an increase in the Treg cell subset from peripheral blood of EOC patients compared with those in healthy controls. Treg infiltration in ascites was higher than in blood into EOC patients. The patients with high infiltration of Treg in blood revealed less overall survival compared to a counterpart with normal levels of Treg. Regarding the association between patients with increased levels of Treg in ascites with overall survival there was no disadvantage found, compared to ascites from patients with normal levels of Treg. \u0000 Conclusion: Study suggests that Treg lymphocytes were increased in ascites and peripheral blood in EOC patients and could be associated with diminished overall survival, via impairment antitumor immune response.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"12373 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-05DOI: 10.15406/MOJI.2016.04.00137
J. Fabre, Y. Merrouche, Bensussan
Submit Manuscript | http://medcraveonline.com The inflammation created by the streptococcus infection attracts and stimulates leucocytes in the tumor microenvironment, which ultimately leads to tumor elimination [5,6]. Recently, it has been demonstrated that malignant cells could build upon inflammation and detour it to their own profit, in reprogramming T helpers lymphocytes on an immunosuppressive mode by interacting with checkpoint proteins pathways like PD1/PD-L1 [7]. Therefore tumor microenvironment elements have been more closely investigated especially pro-inflammatory cytokines. Among them, the interleukin 17 family members, that include IL-17A secreted by Th17 lymphocytes, have shown interesting properties though conflicting [8]. While some authors have reported anti-tumor qualities, other teams like ours have observed proliferation, invasion and chemotherapy resistance enhancing effects [9-11]. Knowledge in the fields of immunology is rapidly improving, particularly in oncology, but not only, and almost every medical specialty has benefited of these discoveries in the past 20 years. In their quest for progress, physicians and researchers must remember that the immune system is multifaceted, having positive effects and their opposite at the same time, balanced by complex mechanisms. That is why advances in immunology can only be reached with hard work, perseverance, and an open mind.
{"title":"The Multifaceted Immune System","authors":"J. Fabre, Y. Merrouche, Bensussan","doi":"10.15406/MOJI.2016.04.00137","DOIUrl":"https://doi.org/10.15406/MOJI.2016.04.00137","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com The inflammation created by the streptococcus infection attracts and stimulates leucocytes in the tumor microenvironment, which ultimately leads to tumor elimination [5,6]. Recently, it has been demonstrated that malignant cells could build upon inflammation and detour it to their own profit, in reprogramming T helpers lymphocytes on an immunosuppressive mode by interacting with checkpoint proteins pathways like PD1/PD-L1 [7]. Therefore tumor microenvironment elements have been more closely investigated especially pro-inflammatory cytokines. Among them, the interleukin 17 family members, that include IL-17A secreted by Th17 lymphocytes, have shown interesting properties though conflicting [8]. While some authors have reported anti-tumor qualities, other teams like ours have observed proliferation, invasion and chemotherapy resistance enhancing effects [9-11]. Knowledge in the fields of immunology is rapidly improving, particularly in oncology, but not only, and almost every medical specialty has benefited of these discoveries in the past 20 years. In their quest for progress, physicians and researchers must remember that the immune system is multifaceted, having positive effects and their opposite at the same time, balanced by complex mechanisms. That is why advances in immunology can only be reached with hard work, perseverance, and an open mind.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-02DOI: 10.15406/MOJI.2016.04.00136
A. Alunno, R. Cardinali, O. Bistoni, S. Caterbi, A. deCosmo, A. Dalbosco, C. Castellini, R. Gerli
In order to investigate the effects of some dietary phytoderivates (Origanum vulgare L. and Rosmarinus officinalis L.) on rabbit immune system, 100 New Zealand mixed-sex rabbits weaned at 30 days of age were split into homogeneous groups submitted to the following dietary treatments: 1) Standard diet (C); 2) C +150 ppm Vit E (E); 3) C +0.2% oregano (O); 4) C +0.2% rosemary (R) and 5) C +0.1% oregano + 0.1% rosemary (OR). Blood samples were drawn from rabbits at 30 and 90 days of age (ten rabbits/diet group at Time 0 and 1, respectively) to investigate the blood lymphocyte subset evolution, the in vitrolymphocyte proliferation (in presence or absence of mitogens) responses and the Immunoglobulin M(IgM) concentration in the supernatants of lymphocyte cultures. A diet effect was observed in the O and OR groups, where the lymphocytes proliferation responses to pokeweed mitogen (PWM; ***P<0.001, in the O group) or the interleukin-2 production (IL-2; ***P<0.001, for both groups) at Time 1 were significantly higher. The IgM levels were systematically higher in the O, OR and E cells culture supernatants (**P<0.01). Age did not affect the rabbit lymphocyte subset evolution nor the in vitrolymphocyte proliferation. Data obtained in the present study show that rabbit’s dietary supplementation with oregano elicits positive effects on the adaptive immune response.
为研究饲粮中植物衍生物(土豆泥和迷迭香)对家兔免疫系统的影响，将100只30日龄断奶新西兰杂交兔分成均匀组，分别饲喂以下饲粮:1)标准饲粮(C);2) C + 150ppm Vit E (E);3) C +0.2%牛至(O);4) C +0.2%迷迭香(R)和5)C +0.1%牛至+0.1%迷迭香(OR)。分别于30日龄和90日龄(10只/日粮组，时间0和1)采血，观察淋巴细胞亚群进化、淋巴细胞增殖(有无丝裂原)反应和淋巴细胞培养上清液中免疫球蛋白M(IgM)浓度。在O和OR组观察到饮食效应，其中淋巴细胞增殖对美洲商陆有丝分裂原(PWM)的反应;***P<0.001，在O组)或白细胞介素-2产生(IL-2;***P<0.001，两组均有统计学差异)。O、OR和E细胞培养上清液中IgM水平均有系统升高(**P<0.01)。年龄对兔淋巴细胞亚群进化和体外淋巴细胞增殖无明显影响。本研究获得的数据表明，家兔日粮中添加牛至对适应性免疫反应有积极的影响。
{"title":"Effects of Oregano (Origanum vulgare L) and Rosemary (Rosmarinus officinalis L) Aqueous Extracts On in vitro Rabbit Immune Responses","authors":"A. Alunno, R. Cardinali, O. Bistoni, S. Caterbi, A. deCosmo, A. Dalbosco, C. Castellini, R. Gerli","doi":"10.15406/MOJI.2016.04.00136","DOIUrl":"https://doi.org/10.15406/MOJI.2016.04.00136","url":null,"abstract":"In order to investigate the effects of some dietary phytoderivates (Origanum vulgare L. and Rosmarinus officinalis L.) on rabbit immune system, 100 New Zealand mixed-sex rabbits weaned at 30 days of age were split into homogeneous groups submitted to the following dietary treatments: 1) Standard diet (C); 2) C +150 ppm Vit E (E); 3) C +0.2% oregano (O); 4) C +0.2% rosemary (R) and 5) C +0.1% oregano + 0.1% rosemary (OR). Blood samples were drawn from rabbits at 30 and 90 days of age (ten rabbits/diet group at Time 0 and 1, respectively) to investigate the blood lymphocyte subset evolution, the in vitrolymphocyte proliferation (in presence or absence of mitogens) responses and the Immunoglobulin M(IgM) concentration in the supernatants of lymphocyte cultures. A diet effect was observed in the O and OR groups, where the lymphocytes proliferation responses to pokeweed mitogen (PWM; ***P<0.001, in the O group) or the interleukin-2 production (IL-2; ***P<0.001, for both groups) at Time 1 were significantly higher. The IgM levels were systematically higher in the O, OR and E cells culture supernatants (**P<0.01). Age did not affect the rabbit lymphocyte subset evolution nor the in vitrolymphocyte proliferation. Data obtained in the present study show that rabbit’s dietary supplementation with oregano elicits positive effects on the adaptive immune response.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"4 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-29DOI: 10.15406/MOJI.2016.04.00135
S. Antwi-Baffour, R. Kyeremeh, J. Adjei, Claudia Aryeh, G. Kpentey, P. Ayeh-Kumi
Background: Acute promyelocytic leukaemia (APL) represents 5-15% of all adult leukaemias. One of the approaches to treat APL is differentiation therapy which works by inducing differentiation of leukaemic promonocytes into mature non-replicative cell types that eventually undergo apoptosis. Plasma Membrane-derived Vesicles, (PMVs) are a heterogeneous group of small, membrane-coated vesicles with phospholipid rich particles, membrane receptors as well as other proteins inherent in their parental cells. There is evidence that PMVs are involved in differentiation in the hematopoietic environment in the bone marrow which suggests a possible involvement in leukaemia myeloid development, and possibly monocytic haematopoiesis. This work aimed to show principally whether PMVs can initiate differentiation/stop proliferation in HL-60 cells (promonocytes) and cause their differentiation into macrophages. This way, PMVs can be considered for differentiation therapy. Methods: PMVs were induced from cells using differential centrifugation. We also employed flow cytometry, ELISA, fluorescent microscopy analysis, SDS-PAGE, western blotting, growth inhibition & differentiation assays, nitroblue tetrazolium assay and cell cycle analysis to conduct our experiments. Results: HL-60 cells treated with PMVs showed a dose-dependent increase in adherence and increased expression of CD11b and CD14 as a sign of differentiation. Morphological changes were induced in HL-60 as well as phosphorylation of the TGF-?/Smad signaling pathway upon treatment with PMVs. Again, TGF-?1-bearing PMVs reduced the proliferation of HL-60 cells and caused them to exit the cell cycle at G0/G1. It was also shown that PMVs from HL60 or THP-1 cells but not from MCF-7 cells significantly reduce the growth rate of HL-60 cells and the reduction in proliferation was dependent on TGF-?1 delivered by the PMVs. Conclusion: This work showed that PMVs (isolated from HL-60 and THP-1 cells) carry TGF-β1 on their membrane surface. These TGF-β1-bearing PMVs can modulate the growth rate of HL-60 promonocytes without inducing apoptosis, the cells exiting the cell cycle at G0/G1. In addition, dramatic changes in the morphology of PMV-treated cells were observed as they became increasingly irregular in shape with membrane extensions resembling pseudopodia. It might therefore be prudent to look at PMV-releasing agents, as potential alternative drugs in differentiation therapy against APL. Background: Acute promyelocytic leukaemia (APL) represents 5-15% of all adult leukaemias. One of the approaches to treat APL is differentiation therapy which works by inducing differentiation of leukaemic promonocytes into mature non-replicative cell types that eventually undergo apoptosis. Plasma Membrane-derived Vesicles, (PMVs) are a heterogeneous group of small, membrane-coated vesicles with phospholipid rich particles, membrane receptors as well as other proteins inherent in their parental cells. There is e
{"title":"Plasma Membrane- Derived Vesicles Shows Effects on the Induction of Differentiation of Promonocytes into Macrophages: A Possible Cancer Therapy","authors":"S. Antwi-Baffour, R. Kyeremeh, J. Adjei, Claudia Aryeh, G. Kpentey, P. Ayeh-Kumi","doi":"10.15406/MOJI.2016.04.00135","DOIUrl":"https://doi.org/10.15406/MOJI.2016.04.00135","url":null,"abstract":"Background: Acute promyelocytic leukaemia (APL) represents 5-15% of all adult leukaemias. One of the approaches to treat APL is differentiation therapy which works by inducing differentiation of leukaemic promonocytes into mature non-replicative cell types that eventually undergo apoptosis. Plasma Membrane-derived Vesicles, (PMVs) are a heterogeneous group of small, membrane-coated vesicles with phospholipid rich particles, membrane receptors as well as other proteins inherent in their parental cells. There is evidence that PMVs are involved in differentiation in the hematopoietic environment in the bone marrow which suggests a possible involvement in leukaemia myeloid development, and possibly monocytic haematopoiesis. This work aimed to show principally whether PMVs can initiate differentiation/stop proliferation in HL-60 cells (promonocytes) and cause their differentiation into macrophages. This way, PMVs can be considered for differentiation therapy. \u0000 \u0000 Methods: PMVs were induced from cells using differential centrifugation. We also employed flow cytometry, ELISA, fluorescent microscopy analysis, SDS-PAGE, western blotting, growth inhibition & differentiation assays, nitroblue tetrazolium assay and cell cycle analysis to conduct our experiments. \u0000 \u0000 Results: HL-60 cells treated with PMVs showed a dose-dependent increase in adherence and increased expression of CD11b and CD14 as a sign of differentiation. Morphological changes were induced in HL-60 as well as phosphorylation of the TGF-?/Smad signaling pathway upon treatment with PMVs. Again, TGF-?1-bearing PMVs reduced the proliferation of HL-60 cells and caused them to exit the cell cycle at G0/G1. It was also shown that PMVs from HL60 or THP-1 cells but not from MCF-7 cells significantly reduce the growth rate of HL-60 cells and the reduction in proliferation was dependent on TGF-?1 delivered by the PMVs. \u0000 \u0000 Conclusion: This work showed that PMVs (isolated from HL-60 and THP-1 cells) carry TGF-β1 on their membrane surface. These TGF-β1-bearing PMVs can modulate the growth rate of HL-60 promonocytes without inducing apoptosis, the cells exiting the cell cycle at G0/G1. In addition, dramatic changes in the morphology of PMV-treated cells were observed as they became increasingly irregular in shape with membrane extensions resembling pseudopodia. It might therefore be prudent to look at PMV-releasing agents, as potential alternative drugs in differentiation therapy against APL. \u0000 \u0000 \u0000 Background: Acute promyelocytic leukaemia (APL) represents 5-15% of all adult leukaemias. One of the approaches to treat APL is differentiation therapy which works by inducing differentiation of leukaemic promonocytes into mature non-replicative cell types that eventually undergo apoptosis. Plasma Membrane-derived Vesicles, (PMVs) are a heterogeneous group of small, membrane-coated vesicles with phospholipid rich particles, membrane receptors as well as other proteins inherent in their parental cells. There is e","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"4 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2016-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-28DOI: 10.15406/MOJI.2016.04.00134
J. Mulry
{"title":"Unique Features of the Muse Auto CD4/CD4% System","authors":"J. Mulry","doi":"10.15406/MOJI.2016.04.00134","DOIUrl":"https://doi.org/10.15406/MOJI.2016.04.00134","url":null,"abstract":"","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-25DOI: 10.15406/MOJI.2016.04.00132
Iravathy Goud, Kavitha Matam, R. Vempati, Abdullah A. Alyousef, K. Alharbi, I. Khan
Oligodendroglial tumors represent approximately 4-7% of all gliomas. The discovery of 1p and 19q chromosomal arms deletion in glial tumour influence the diagnosis and more accurate prediction of chemotherapy response. As a result, an attempt has been made to detect deletion using fluorescent insitu hybridization (FISH) and to determine its prognostic value in a cohort of glial tumour patients from Hyderabad population. The FISH analysis was carried out on 90 FFPE tissue sections by using Vysis LSI 1p36/LSI 1q25 and LSI 19p13/LSI 19q13 dual colored FISH probe sets. Signals were scored from 150-250 non-overlapping, intact nuclei. The analysis for 1p and 19q deletions was observed in (21/35) 60% of oligodendroglyomas which included (8/21) 38.1% of grade II and (13/21) 61.9% of grade III. Isolated 19q deletion was seen in (1/21) 4.7% & lone 1p loss was not observed in oligodendroglyomas. In mixed oligoastrocytomas combined 1p/19q loss was observed in (7/16) 43.75% cases, including one grade II and 6 grade III tumors and 1/16 (6.25%) showed isolated 1p loss & 19q deletion. This disorder was not observed in astrocytomas. The oligodendroglial phenotype was found to be significantly associated with a loss of 1p (p< 0.05), a loss of 19q (p<0.05) and a combined loss of 1p and 19q (p< 0.05). Frontal location of a tumor occurred to be a statistically significant factor unfavorable for prognosis, p<0.05. The result of our study concludes 1p/19q deletions have prognostic significance and determines deletion 1p/19q by FISH into diagnostic and treatment algorithm in gliomas.
{"title":"Screening of Glioma Patients for 1p/19q Region with Fluorescent Probes","authors":"Iravathy Goud, Kavitha Matam, R. Vempati, Abdullah A. Alyousef, K. Alharbi, I. Khan","doi":"10.15406/MOJI.2016.04.00132","DOIUrl":"https://doi.org/10.15406/MOJI.2016.04.00132","url":null,"abstract":"Oligodendroglial tumors represent approximately 4-7% of all gliomas. The discovery of 1p and 19q chromosomal arms deletion in glial tumour influence the diagnosis and more accurate prediction of chemotherapy response. As a result, an attempt has been made to detect deletion using fluorescent insitu hybridization (FISH) and to determine its prognostic value in a cohort of glial tumour patients from Hyderabad population. The FISH analysis was carried out on 90 FFPE tissue sections by using Vysis LSI 1p36/LSI 1q25 and LSI 19p13/LSI 19q13 dual colored FISH probe sets. Signals were scored from 150-250 non-overlapping, intact nuclei. The analysis for 1p and 19q deletions was observed in (21/35) 60% of oligodendroglyomas which included (8/21) 38.1% of grade II and (13/21) 61.9% of grade III. Isolated 19q deletion was seen in (1/21) 4.7% & lone 1p loss was not observed in oligodendroglyomas. In mixed oligoastrocytomas combined 1p/19q loss was observed in (7/16) 43.75% cases, including one grade II and 6 grade III tumors and 1/16 (6.25%) showed isolated 1p loss & 19q deletion. This disorder was not observed in astrocytomas. The oligodendroglial phenotype was found to be significantly associated with a loss of 1p (p< 0.05), a loss of 19q (p<0.05) and a combined loss of 1p and 19q (p< 0.05). Frontal location of a tumor occurred to be a statistically significant factor unfavorable for prognosis, p<0.05. The result of our study concludes 1p/19q deletions have prognostic significance and determines deletion 1p/19q by FISH into diagnostic and treatment algorithm in gliomas.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-25DOI: 10.15406/moji.2016.04.00133
P. Terlika, it Sood
The focus of this review is to discuss the role of eosinophils in cancer. A study published in the Journal of Clinical Oncology examined the relationship between eosinophils in peripheral blood and the incidence of colorectal cancer [2]. The researchers found that a higher number of peripheral blood eosinophils were associated with a reduced risk of dying from colorectal cancer, especially in patients who never smoked and in males. Although the study could not identify the mechanism to explain this relationship, one plausible theory is that a more active immune system reduces the risk of developing colorectal cancer. Another study published in the journal Modern Pathology in 2016. Prizement et al. [3] looked at how eosinophils might predict outcomes for patients with colorectal cancer. Taghizadeh et al. [4] found no associations between objective allergy markers and cancer in a total population but reported positivity and a high number of eosinophils with association to reduced risk to die of cancer in specific subgroups. Although staging of colorectal cancer typically is based on information about the tumor itself, lymph node involvement, and the presence of metastases (cancer spread to other sites), often two patients with the same staging will have dramatically different outcome. The authors of this study examined whether eosinophils levels in or around a colorectal tumor helps predict outcome. They concluded that a higher numbers of eosinophils around the primary colorectal tumor were associated with an improved patient outcome, and that they should be routinely counted during tumor examination, it was found that the infiltration of tumors with eosinophils, especially in stromal tissue, may be an important prognostic factor in colorectal cancer.
{"title":"Eosinophils and Cancer – Mini Review","authors":"P. Terlika, it Sood","doi":"10.15406/moji.2016.04.00133","DOIUrl":"https://doi.org/10.15406/moji.2016.04.00133","url":null,"abstract":"The focus of this review is to discuss the role of eosinophils in cancer. A study published in the Journal of Clinical Oncology examined the relationship between eosinophils in peripheral blood and the incidence of colorectal cancer [2]. The researchers found that a higher number of peripheral blood eosinophils were associated with a reduced risk of dying from colorectal cancer, especially in patients who never smoked and in males. Although the study could not identify the mechanism to explain this relationship, one plausible theory is that a more active immune system reduces the risk of developing colorectal cancer. Another study published in the journal Modern Pathology in 2016. Prizement et al. [3] looked at how eosinophils might predict outcomes for patients with colorectal cancer. Taghizadeh et al. [4] found no associations between objective allergy markers and cancer in a total population but reported positivity and a high number of eosinophils with association to reduced risk to die of cancer in specific subgroups. Although staging of colorectal cancer typically is based on information about the tumor itself, lymph node involvement, and the presence of metastases (cancer spread to other sites), often two patients with the same staging will have dramatically different outcome. The authors of this study examined whether eosinophils levels in or around a colorectal tumor helps predict outcome. They concluded that a higher numbers of eosinophils around the primary colorectal tumor were associated with an improved patient outcome, and that they should be routinely counted during tumor examination, it was found that the infiltration of tumors with eosinophils, especially in stromal tissue, may be an important prognostic factor in colorectal cancer.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-18DOI: 10.15406/MOJI.2016.04.00130
M. Khalil
DES are clearly used by most of practicing interventional cardiologists for the management of CAD, particularly, in acute coronary syndromes (ACS) based on current guidelines based on mount evidence of clinical trials comparing different DES to BMS with clear superiority in favor of DES [1-16]. CAD is prevalent worldwide with variable presentations necessitating appropriate management guidelines that supported that superiority is convincing justification of the high price of DES [17-28].
{"title":"The Doctor the Surgeon and the Device Installer: Nor Stent #EscCongress 2016 Rome","authors":"M. Khalil","doi":"10.15406/MOJI.2016.04.00130","DOIUrl":"https://doi.org/10.15406/MOJI.2016.04.00130","url":null,"abstract":"DES are clearly used by most of practicing interventional cardiologists for the management of CAD, particularly, in acute coronary syndromes (ACS) based on current guidelines based on mount evidence of clinical trials comparing different DES to BMS with clear superiority in favor of DES [1-16]. CAD is prevalent worldwide with variable presentations necessitating appropriate management guidelines that supported that superiority is convincing justification of the high price of DES [17-28].","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-18DOI: 10.15406/moji.2016.04.00128
A. LigiaARodríguez
{"title":"Sensitization to Anisakis Simplex in Atopics Patients and its Relation with Reactivity to Mites, Cockroach, Seafood and Fish","authors":"A. LigiaARodríguez","doi":"10.15406/moji.2016.04.00128","DOIUrl":"https://doi.org/10.15406/moji.2016.04.00128","url":null,"abstract":"","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67085443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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