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Rapidly degradable konjac glucomannan hydrogels cross-linked with olsalazine for colonic drug release. 与奥萨拉嗪交联的可快速降解魔芋葡甘露聚糖水凝胶用于结肠药物释放。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230066
Qiao Zhang, Huili Fu, Yunfei Zhang, Liang Li, Guoping Yan

Background: Polysaccharide hydrogel is one of the most important materials for the colon target drug release system. However, the degradation time of polysaccharide hydrogel is much longer than the retention time in the colon. The drugs are expelled from the body before being released.

Objective: In order to match the degradation of drug carriers and their retention time in the colon, a rapidly degradable konjac glucomannan (KGM) hydrogel was designed for colon target drug release.

Methods: A crosslinker containing azo bond, olsalazine, was used to prepare the rapidly degradable KGM hydrogel. The degradation and drug release of the hydrogels with different crosslinking densities in the normal buffer and the human fecal medium were studied to evaluate the efficiency of colon drug release.

Results: More than 50% of the KGM hydrogel by weight was degraded and more than 60% of the 5-fluorouracil (5-Fu) was released within 48 h in 5% w/v human fecal medium.

Conclusion: The drug was released more rapidly in a simulated colon environment than in a normal buffer. Furthermore, the drug release was controlled by the degradation of the hydrogel. The KGM hydrogel containing azo crosslinker has great potential for colon drug release.

背景:多糖水凝胶是结肠靶向药物释放系统最重要的材料之一。然而,多糖水凝胶的降解时间远远长于药物在结肠中的滞留时间。因此,药物在释放前会被排出体外:为了使药物载体的降解和在结肠中的保留时间相匹配,我们设计了一种可快速降解的魔芋葡甘露聚糖(KGM)水凝胶,用于结肠靶向药物释放:方法:使用含偶氮键的交联剂奥萨拉嗪制备可快速降解的魔芋葡甘露聚糖(KGM)水凝胶。研究了不同交联密度的水凝胶在正常缓冲液和人体粪便培养基中的降解和药物释放情况,以评估结肠药物释放的效率:以重量计,超过50%的KGM水凝胶在5% w/v的人类粪便培养基中降解,超过60%的5-氟尿嘧啶(5-Fu)在48小时内释放:结论:与普通缓冲液相比,药物在模拟结肠环境中的释放速度更快。此外,药物的释放受水凝胶降解的控制。含有偶氮交联剂的 KGM 水凝胶在结肠药物释放方面具有很大的潜力。
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引用次数: 0
Spatial preference behavior of robo-pigeons induced by electrical stimulus targeting fear nuclei. 以恐惧核为目标的电刺激诱发机器人鸽的空间偏好行为
IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-01-01 DOI: 10.3233/BME-240048
Yanna Ping, Huanhuan Peng, Yongjun Zhu, Yuhao Feng, Yexin Zhang, Xiaomin Qi, Xinyu Liu

Background: Numerous studies have confirmed that stimulating the mid-brain motor nuclei can regulate movement forcibly for robo-pigeons, but research on behavior modulation using non-motor nuclei is scarce.

Objective: In this study, we constructed a spatial preference behavior by stimulating the stratum griseum periventriculare (SGP), a nucleus correlated with fear and escape, for robo-pigeons.

Methods: The study was carried out in a square-enclosed experimental field, with a designated box serving as the 'safe' area for the robo-pigeons. If the robo-pigeon exits this area, the SGP will be stimulated. After a brief training period, the robo-pigeons will have a clear spatial preference for the box.

Results: The result from five pigeons has shown that, after simple training, the animals develop a spatial preference for the box. They can quickly return to the box in any situation when the SGP is stimulated, with a success rate exceeding 80% (89.0 ± 6.5%). Moreover, this behavior is highly stable and remains consistent, unaffected by changes in the location of the box or the interference box.

Conclusion: The results prove that using the electrical stimulus could enable animals to accomplish more complex tasks. It may offer a novel approach to regulating pigeon behavior and further advance the study of cyborg animals.

背景:大量研究证实,刺激中脑运动核团可以强制调节机器鸽的运动,但利用非运动核团调节行为的研究却很少:本研究中,我们通过刺激与恐惧和逃跑相关的脑室周围灰质层(SGP),为机器鸽构建了一种空间偏好行为:研究在一个方形封闭的实验场地中进行,实验场地中有一个指定的盒子作为机器鸽的 "安全 "区域。如果机器鸽离开这个区域,SGP 就会受到刺激。经过短暂的训练后,机器鸽会对盒子产生明显的空间偏好:五只鸽子的训练结果表明,经过简单的训练后,鸽子会对盒子产生空间偏好。在任何情况下,当刺激 SGP 时,它们都能迅速返回盒子,成功率超过 80%(89.0 ± 6.5%)。此外,这种行为还具有高度稳定性和连贯性,不受盒子位置或干扰盒变化的影响:结果证明,使用电刺激可以使动物完成更复杂的任务。这可能为调节鸽子行为提供了一种新方法,并进一步推动了对半机械动物的研究。
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引用次数: 0
Aloe vera mucilage loaded gelatin electrospun fibers contained in polylactic acid coaxial system and polylactic acid and poly(e-caprolactone) tri-layer membranes for tissue engineering. 用于组织工程的聚乳酸同轴系统和聚乳酸与聚(e-己内酯)三层膜所含的芦荟粘液负载明胶电纺纤维。
IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-01-01 DOI: 10.3233/BME-240050
María Mónica Castillo Ortega, Jesús Manuel Quiroz Castillo, Teresa Del Castillo Castro, Dora Evelia Rodriguez Felix, Hisila Del Carmen Santacruz Ortega, Octavio Manero, Karla Alejandra Lopez Gastelum, Lerma Hanaiy Chan Chan, Diego Hernandez Martinez, Jose Agustin Tapia Hernández, Damian Francisco Plascencia Martínez

Background: Polymeric electrospun mats have been used as scaffolds in tissue engineering for the development of novel materials due to its characteristics. The usage of synthetic materials has gone in decline due to environmental problems associated with their synthesis and waste disposal. Biomaterials such as biopolymers have been used recently due to good compatibility on biological applications and sustainability.

Objective: The purpose of this work is to obtain novel materials based on synthetic and natural polymers for applications on tissue engineering.

Methods: Aloe vera mucilage was obtained, chemically characterized, and used as an active compound contained in electrospun mats. Polymeric scaffolds were obtained in single, coaxial and tri-layer structures, characterized and evaluated in cell culture.

Results: Mucilage loaded electrospun fibers showed good compatibility due to formation of hydrogen bonds between polymers and biomolecules from its structure, evidenced by FTIR spectra and thermal properties. Cell viability test showed that most of the obtained mats result on viability higher than 75%, resulting in nontoxic materials, ready to be used on scaffolding applications.

Conclusion: Mucilage containing fibers resulted on materials with potential use on scaffolding applications due to their mechanical performance and cell viability results.

背景:聚合物电纺垫因其特性被用作组织工程中的支架,用于开发新型材料。由于合成材料的合成和废物处理所带来的环境问题,合成材料的使用已日渐减少。生物材料(如生物聚合物)由于在生物应用方面具有良好的兼容性和可持续性,最近得到了广泛应用:这项工作的目的是获得基于合成和天然聚合物的新型材料,用于组织工程:方法:获得芦荟粘液,对其进行化学表征,并将其用作电纺垫中的活性化合物。获得了单层、同轴和三层结构的聚合物支架,并对其进行了表征和细胞培养评估:傅立叶变换红外光谱和热性能表明,由于聚合物和生物大分子之间形成氢键,粘液负载电纺纤维显示出良好的兼容性。细胞存活率测试表明,获得的大多数纤维毡的存活率高于 75%,因此是无毒材料,可用于支架应用:结论:由于其机械性能和细胞存活率结果,含黏液纤维的材料具有支架应用的潜力。
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引用次数: 0
Enhanced mechanic properties of calcium phosphate cements via mussel-inspired adhesive as bone substitute: Highlights of their interactions. 通过贻贝启发粘合剂作为骨替代物增强磷酸钙水门汀的力学性能:它们之间相互作用的亮点。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230017
Rupan Yuan, Sijie Zhou, Xiong Xiong, Dan Yang, Donghu Lin, Taiyi Li, Bin He, Guihua Wei, Shuxin Qu

Background: Inspired by natural bones, many organic components were added to Calcium Phosphate Cements (CPCs) to improve their mechanical strength. However, the strength of these composite CPCs is limited by the low strength of organic components itself and the weak interaction between organic components and CPCs.

Objective: Firstly, a composite CPC containing mussel-inspired adhesive, Poly-(Dopamine Methacrylamide-co-2-methoxy Ethylacrylate) (pDM) was developed. Secondly, the interactions between pDM and CPC and their effect on mechanical properties were investigated.

Methods: The interactions between pDM and CPC were performed by Nuclear Magnetic Resonance, Laser Raman, X-ray Photoelectron Spectroscopy, Fourier Transform-Infrared Spectroscopy and X-ray Diffraction Analysis.

Results: The toughness and compressive strength of pDM-CPC scaffold were both significantly enhanced, because of the enhanced interface binding strength among CPC and pDM due to their interaction and the improved mechanical strength of pDM owing to its self-oxidation cross-linking. The toughness of pDM-CPC scaffolds increased with the increased contents of pDM, while pDM-CPC scaffold containing 35 wt.% pDM had the highest compressive strength of all, which the latter was more than five times compared to that of CPC.

Conclusion: The mechanically strong pDM-CPC scaffolds has potential application in bone regeneration as well as in craniofacial and orthopedic repair.

背景:受天然骨骼的启发,许多有机成分被添加到磷酸钙水泥(CPC)中,以提高其机械强度。然而,这些复合 CPC 的强度受到有机成分本身强度低以及有机成分与 CPC 之间相互作用弱的限制:首先,开发了一种含有贻贝启发粘合剂聚多巴胺甲基丙烯酰胺-2-甲氧基乙基丙烯酸酯(pDM)的复合 CPC。其次,研究了 pDM 与 CPC 之间的相互作用及其对机械性能的影响:方法:采用核磁共振、激光拉曼、X 射线光电子能谱、傅立叶变换红外光谱和 X 射线衍射分析法研究 pDM 与 CPC 之间的相互作用:结果:pDM-CPC 支架的韧性和抗压强度均显著提高,这是由于 CPC 和 pDM 之间的相互作用增强了界面结合强度,而 pDM 的自氧化交联又提高了机械强度。pDM-CPC 支架的韧性随着 pDM 含量的增加而增加,而含有 35 wt.% pDM 的 pDM-CPC 支架的抗压强度最高,是 CPC 支架的五倍多:结论:机械强度高的 pDM-CPC 支架在骨再生以及颅面和骨科修复中具有潜在的应用价值。
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引用次数: 0
Evaluating the efficacy of the punch-out technique in systemic-to-pulmonary shunts: A computational fluid dynamics approach. 评估全身-肺分流术中打孔技术的功效:计算流体动力学方法。
IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-01-01 DOI: 10.3233/BME-240022
Shiho Yamazaki, Ryosuke Kowatari, Tetsuya Yano, Hanae Sasaki, Kazuyuki Daitoku, Masahito Minakawa

Background: Systemic-to-pulmonary shunt is a palliative procedure used to decrease pulmonary blood flow in congenital heart diseases. Shunt stenosis or occlusion has been reported to be associated with mortality; therefore, the management of thrombotic complications remains a challenge for most congenital cardiovascular surgeons. Despite its importance, the optimal method for shunt anastomosis remains unclear.

Objective: The study investigates the clinical benefits of the punch-out technique over conventional methods in the anastomosis process of Systemic-to-pulmonary shunt, focusing on its potential to reduce shunt-related complications.

Methods: Anastomotic models were created by two different surgeons employing both traditional slit and innovative punch-out techniques. Computational tomography was performed to construct three-dimensional models for computational fluid dynamics (CFD) analysis. We assessed the flow pattern, helicity, magnitude of wall shear stress, and its gradient.

Results: The anastomotic flow area was larger in the model using the punch-out technique than in the slit model. In CFD simulation, we found that using the punch-out technique decreases the likelihood of establishing a high wall shear stress distribution around the anastomosis line in the model.

Conclusion: The punch-out technique emerges as a promising method in SPS anastomosis, offering a reproducible and less skill-dependent alternative that potentially diminishes the risk of shunt occlusion, thereby enhancing patient outcomes.

背景:全身-肺分流术是一种用于减少先天性心脏病肺血流量的姑息性手术。据报道,分流管狭窄或闭塞与死亡率有关;因此,血栓并发症的处理仍然是大多数先天性心血管外科医生面临的挑战。尽管分流吻合术非常重要,但其最佳方法仍不明确:本研究探讨了在系统-肺分流术吻合过程中,打孔技术相对于传统方法的临床优势,重点关注其减少分流术相关并发症的潜力:方法:两位不同的外科医生采用传统的缝合技术和创新的打孔技术制作了吻合口模型。方法:两位不同的外科医生分别采用传统的缝合技术和创新的打孔技术制作了吻合口模型,并通过计算断层扫描技术构建了用于计算流体动力学(CFD)分析的三维模型。我们评估了流动模式、螺旋度、壁剪应力大小及其梯度:结果:与狭缝模型相比,采用打孔技术的模型吻合口血流面积更大。在 CFD 模拟中,我们发现使用打孔技术降低了在模型吻合口周围形成高壁剪应力分布的可能性:结论:打孔技术在 SPS 吻合术中是一种很有前途的方法,它提供了一种可重复性强、对技术依赖性较低的替代方法,有可能降低分流管闭塞的风险,从而改善患者的预后。
{"title":"Evaluating the efficacy of the punch-out technique in systemic-to-pulmonary shunts: A computational fluid dynamics approach.","authors":"Shiho Yamazaki, Ryosuke Kowatari, Tetsuya Yano, Hanae Sasaki, Kazuyuki Daitoku, Masahito Minakawa","doi":"10.3233/BME-240022","DOIUrl":"10.3233/BME-240022","url":null,"abstract":"<p><strong>Background: </strong>Systemic-to-pulmonary shunt is a palliative procedure used to decrease pulmonary blood flow in congenital heart diseases. Shunt stenosis or occlusion has been reported to be associated with mortality; therefore, the management of thrombotic complications remains a challenge for most congenital cardiovascular surgeons. Despite its importance, the optimal method for shunt anastomosis remains unclear.</p><p><strong>Objective: </strong>The study investigates the clinical benefits of the punch-out technique over conventional methods in the anastomosis process of Systemic-to-pulmonary shunt, focusing on its potential to reduce shunt-related complications.</p><p><strong>Methods: </strong>Anastomotic models were created by two different surgeons employing both traditional slit and innovative punch-out techniques. Computational tomography was performed to construct three-dimensional models for computational fluid dynamics (CFD) analysis. We assessed the flow pattern, helicity, magnitude of wall shear stress, and its gradient.</p><p><strong>Results: </strong>The anastomotic flow area was larger in the model using the punch-out technique than in the slit model. In CFD simulation, we found that using the punch-out technique decreases the likelihood of establishing a high wall shear stress distribution around the anastomosis line in the model.</p><p><strong>Conclusion: </strong>The punch-out technique emerges as a promising method in SPS anastomosis, offering a reproducible and less skill-dependent alternative that potentially diminishes the risk of shunt occlusion, thereby enhancing patient outcomes.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"425-437"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcutaneous tissue reaction to a novel nano zinc oxide eugenol dental cement. 新型纳米氧化锌丁香酚牙水泥的皮下组织反应。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230118
Rohmat Nursin, Masitah Hayati Harun, Dasmawati Mohamad, Siti Khadijah Mohd Bakhori, Shahrom Mahmud

Background: Zinc oxide eugenol (ZOE) cement is a popular dental material due mainly to its analgesic, antibacterial and anti-inflammatory effects. The formulation of ZOE cement from nano particle-sized zinc oxide (ZnO) has the potential to increase these properties as well as reduce its adverse effects to the surrounding tissues.

Objective: This study evaluated the subcutaneous tissue response towards nano ZOE cements (ZOE-A and ZOE-B) in comparison to conventional ZOE (ZOE-K).

Methods: Test materials were implanted into 15 New Zealand white rabbits. Tissue samples were obtained after 7, 14, and 30 days (n = 5 per period) for histopathological evaluation of inflammatory cell infiltrate, fibrous tissue condensation, and abscess formation.

Results: ZOE-A showed the lowest score for the variable macrophage and lymphocyte at day 7. Both ZOE-A and ZOE-B presented lower fibrous tissue condensation and abscess formation compared to conventional ZOE-K. By day 30, ZOE-A exhibited less lymphocytic and neutrophilic infiltrate compared to the other materials, while ZOE-B had the lowest score for macrophages. ZOE-K exerted higher inflammatory cell response at almost all of the experimental periods. All of the materials resulted in thin fiber condensation after 30 days.

Conclusions: Rabbit tissue implanted with ZOE-A and ZOE-B showed better response compared to ZOE-K.

背景:氧化锌丁香酚(ZOE)水泥是一种流行的牙科材料,主要是因为它具有镇痛、抗菌和抗炎的作用。由纳米颗粒大小的氧化锌(ZnO)制成的ZOE水泥有可能增加这些性能,并减少其对周围组织的不利影响。目的:本研究评估纳米ZOE胶合剂(ZOE- a和ZOE- b)与常规ZOE胶合剂(ZOE- k)的皮下组织反应。方法:将实验材料植入15只新西兰大白兔体内。在第7、14和30天(每个周期n = 5)后获得组织样本,用于炎症细胞浸润、纤维组织凝结和脓肿形成的组织病理学评估。结果:ZOE-A在第7天表现为可变巨噬细胞和淋巴细胞评分最低。与传统的ZOE-K相比,ZOE-A和ZOE-B的纤维组织凝结和脓肿形成都较低。第30天,与其他材料相比,ZOE-A的淋巴细胞和中性粒细胞浸润较少,而ZOE-B的巨噬细胞评分最低。ZOE-K几乎在所有实验期间都表现出较高的炎症细胞反应。所有材料在30天后都出现了薄纤维凝结。结论:与ZOE-K相比,植入ZOE-A和ZOE-B的兔组织有更好的应答。
{"title":"Subcutaneous tissue reaction to a novel nano zinc oxide eugenol dental cement.","authors":"Rohmat Nursin, Masitah Hayati Harun, Dasmawati Mohamad, Siti Khadijah Mohd Bakhori, Shahrom Mahmud","doi":"10.3233/BME-230118","DOIUrl":"10.3233/BME-230118","url":null,"abstract":"<p><strong>Background: </strong>Zinc oxide eugenol (ZOE) cement is a popular dental material due mainly to its analgesic, antibacterial and anti-inflammatory effects. The formulation of ZOE cement from nano particle-sized zinc oxide (ZnO) has the potential to increase these properties as well as reduce its adverse effects to the surrounding tissues.</p><p><strong>Objective: </strong>This study evaluated the subcutaneous tissue response towards nano ZOE cements (ZOE-A and ZOE-B) in comparison to conventional ZOE (ZOE-K).</p><p><strong>Methods: </strong>Test materials were implanted into 15 New Zealand white rabbits. Tissue samples were obtained after 7, 14, and 30 days (n = 5 per period) for histopathological evaluation of inflammatory cell infiltrate, fibrous tissue condensation, and abscess formation.</p><p><strong>Results: </strong>ZOE-A showed the lowest score for the variable macrophage and lymphocyte at day 7. Both ZOE-A and ZOE-B presented lower fibrous tissue condensation and abscess formation compared to conventional ZOE-K. By day 30, ZOE-A exhibited less lymphocytic and neutrophilic infiltrate compared to the other materials, while ZOE-B had the lowest score for macrophages. ZOE-K exerted higher inflammatory cell response at almost all of the experimental periods. All of the materials resulted in thin fiber condensation after 30 days.</p><p><strong>Conclusions: </strong>Rabbit tissue implanted with ZOE-A and ZOE-B showed better response compared to ZOE-K.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"139-151"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Varus/valgus stability in imageless robotic-assisted total knee arthroplasty applying three-dimensional assessment of varus/valgus stress X-rays. 应用内翻/外翻应力x射线三维评估在无图像机器人辅助全膝关节置换术中的内翻/外翻稳定性。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230146
Hiroki Hijikata, Tomoharu Mochizuki, Keisuku Maeda, Osamu Tanifuji, Go Omori, Noriaki Yamamoto, Hiroyuki Kawashima

Background: The postoperative varus/valgus stability assessment in stress X-rays has been established as an evaluation index. However, it is performed by the two-dimensional (2D) method rather than the three-dimensional (3D) method.

Objective: This study aimed to identify the precision and reproducibility of measuring varus/valgus stress X-rays three-dimensionally and to examine varus/valgus stability under anesthesia in imageless robotic assisted total knee arthroplasty (rTKA).

Methods: This prospective study analyzed 52 consecutive rTKAs (five males, 67 ± 5.3 years; 47 females, 74 ± 5.9 years). Postoperative varus/valgus stress X-rays in knee extension under anesthesia at manual maximum stress were three-dimensionally assessed by 2D-3D image matching technique using the 3D bone and component models. Varus/valgus angle between components (VV angle) in no stress, valgus stress, varus stress, medial joint opening (MJO), and lateral joint opening (LJO) were evaluated, clarifying this method's precision and reproducibility and valgus/varus stability.

Results: All parameters' precision and reproducibility had <1° mean differences and high intra- and inter-class correlation coefficients. Bland-Altman plots showed no fixed and proportional bias. Non-stress VV angle, valgus VV angle, varus VV angle, MJO, and LJO were 3.6 ± 1.2°, 1.0 ± 1.4°, 7.1 ± 1.9°, 1.5 ± 1.0 mm, and 2.8 ± 2.7 mm, respectively.

Conclusion: This prospective study demonstrated that (1) the three-dimensional measurement method provided sufficient precision and reproducibility, and (2) the rTKAs could achieve good postoperative varus/valgus stability with a small standard deviation.

背景:已经建立了应力x线术后内翻/外翻稳定性评价作为一种评价指标。然而,它是通过二维(2D)方法而不是三维(3D)方法来执行的。目的:研究机器人辅助全膝关节置换术(rTKA)中三维测量内翻/外翻应力x线的准确性和重复性,并检查麻醉下内翻/外翻的稳定性。方法:本前瞻性研究分析了52例连续rtka患者(男性5例,67±5.3岁;女性47例,74±5.9岁)。采用3D骨和部件模型,采用2D-3D图像匹配技术,对麻醉下人工最大应力下膝关节伸展术后内翻/外翻应力x线进行三维评估。对无应力、外翻应力、内翻应力、内侧关节开口(MJO)和外侧关节开口(LJO)情况下各组件间内翻角(VV角)进行了评价,阐明了该方法的精确性、重复性和外翻稳定性。结论:本前瞻性研究表明:(1)三维测量方法具有足够的精度和重复性;(2)rtka可实现良好的术后内翻/外翻稳定性,标准偏差小。
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引用次数: 0
Surface hardening of Ti-Al-V superalloy spinal implant by using the boronization method. 使用硼化方法对 Ti-Al-V 超合金脊柱植入物进行表面硬化。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230033
Mehdi Hekimoğlu, Hıdır Özer, Kamil Kiraz, Ceylan Onursal, Ferit Siyahcan, Ali Fahir Özer

Background: We compared the raw Ti-Al-V super alloy transpedicular implant screws with boronized and surface-hardened transpedicular implant screws.

Objective: To improve patients' postoperative prognosis with the production of harder and less fragile screws.

Methods: Surface hardening was achieved by applying green-body encapsulation of the specimen with elemental boron paste which is sintered at elevated temperatures to ensure the boron-metal diffusion. Boron transported into the Ti-Al-V super alloy matrix gradually while suppressing aluminum and a homogeneously boronized surface with a thickness of ∼15 microns was obtained. The uniform external shell was enriched with TiB2, which is one of the hardest ceramics. The Ti-Al-V core material, where boron penetration diminishes, shows cohesive transition and ensures intact core-surface structure.

Results: Scanning electron microscope images confirmed a complete homogeneous, uniform and non-laminating surface formation. Energy-dispersive X-ray monitored the elemental structural mapping and proved the replacement of the aluminum sites on the surface with boron ending up the TiB2. The procedure was 8.6 fold improved the hardness and the mechanical resistance of the tools.

Conclusions: Surface-hardened, boronized pedicular screws can positively affect the prognosis. In vivo studies are needed to prove the safety of use.

背景:我们比较了未加工的 Ti-Al-V 超级合金经关节植入螺钉与硼化和表面硬化的经关节植入螺钉:目的:生产硬度更高、更不易碎的螺钉,改善患者的术后预后:方法:用元素硼浆对试样进行绿体封装,在高温下烧结以确保硼金属扩散,从而实现表面硬化。硼逐渐向 Ti-Al-V 超级合金基体中迁移,同时抑制铝的迁移,从而获得厚度为 15 微米的均匀硼化表面。均匀的外部外壳富含最坚硬的陶瓷之一 TiB2。硼渗透减少的 Ti-Al-V 核心材料显示出内聚过渡,确保了完整的核心-表面结构:结果:扫描电子显微镜图像证实了完全均匀、一致和无层压的表面形成。能量色散 X 射线监测了元素结构图,证明硼取代了表面的铝位点,最终形成了 TiB2。该工艺将工具的硬度和机械阻力提高了 8.6 倍:结论:表面硬化、硼化的足弓螺钉可对预后产生积极影响。要证明使用的安全性,还需要进行体内研究。
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引用次数: 0
Experimental characterization of motion resistance of the sacroiliac joint. 骶髂关节运动阻力的实验特征。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230041
Ryota Toyohara, Niels Hammer, Toshiro Ohashi

Background: The human sacroiliac joint (SIJ) in vivo is exposed to compressive and shearing stress environment, given the joint lines are almost parallel to the direction of gravity. The SIJ supports efficient bipedal walking. Unexpected or unphysiological, repeated impacts are believed to cause joint misalignment and result in SIJ pain. In the anterior compartment of the SIJ being synovial, the articular surface presents fine irregularities, potentially restricting the motion of the joints.

Objective: To clarify how the SIJ articular surface affects the resistance of the motion under physiological loading.

Methods: SIJ surface models were created based on computed tomography data of three patients and subsequently 3D printed. Shear resistance was measured in four directions and three combined positions using a customized setup. In addition, repositionability of SIJs was investigated by unloading a shear force.

Results: Shear resistance of the SIJ was the highest in the inferior direction. It changed depending on the direction of the shear and the alignment position of the articular surface.

Conclusion: SIJ articular surface morphology is likely designed to accommodate upright bipedal walking. Joint misalignment may in consequence increase the risk of subluxation.

背景:人体骶髂关节(SIJ)的关节线几乎与重力方向平行,因此在体内暴露于压缩和剪切应力环境中。骶髂关节支持有效的双足行走。人们认为,意外或非生理性的反复撞击会造成关节错位,导致 SIJ 疼痛。在滑膜的 SIJ 前腔,关节表面呈现细微的不规则,可能会限制关节的运动:阐明在生理负荷下,SIJ 关节面如何影响运动阻力:方法:根据三名患者的计算机断层扫描数据创建 SIJ 表面模型,随后进行 3D 打印。使用定制装置测量了四个方向和三个组合位置的剪切阻力。此外,还通过卸载剪切力研究了 SIJ 的重新定位能力:结果:SIJ 下方向的剪切阻力最大。结论:结论:SIJ关节表面形态的设计可能是为了适应直立双足行走。因此,关节错位可能会增加半脱位的风险。
{"title":"Experimental characterization of motion resistance of the sacroiliac joint.","authors":"Ryota Toyohara, Niels Hammer, Toshiro Ohashi","doi":"10.3233/BME-230041","DOIUrl":"10.3233/BME-230041","url":null,"abstract":"<p><strong>Background: </strong>The human sacroiliac joint (SIJ) in vivo is exposed to compressive and shearing stress environment, given the joint lines are almost parallel to the direction of gravity. The SIJ supports efficient bipedal walking. Unexpected or unphysiological, repeated impacts are believed to cause joint misalignment and result in SIJ pain. In the anterior compartment of the SIJ being synovial, the articular surface presents fine irregularities, potentially restricting the motion of the joints.</p><p><strong>Objective: </strong>To clarify how the SIJ articular surface affects the resistance of the motion under physiological loading.</p><p><strong>Methods: </strong>SIJ surface models were created based on computed tomography data of three patients and subsequently 3D printed. Shear resistance was measured in four directions and three combined positions using a customized setup. In addition, repositionability of SIJs was investigated by unloading a shear force.</p><p><strong>Results: </strong>Shear resistance of the SIJ was the highest in the inferior direction. It changed depending on the direction of the shear and the alignment position of the articular surface.</p><p><strong>Conclusion: </strong>SIJ articular surface morphology is likely designed to accommodate upright bipedal walking. Joint misalignment may in consequence increase the risk of subluxation.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"53-63"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability and validity of estimated angles information assessed using inertial measurement unit-based motion sensors. 使用基于惯性测量单元的运动传感器评估估计角度信息的可靠性和有效性。
IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-01-01 DOI: 10.3233/BME-240031
Taiki Morikawa, Nariyuki Mura, Toshiaki Sato, Hiroshi Katoh

Background: Inertial measurement unit (IMU)-based motion sensors are affordable, and their use is appropriate for rehabilitation. However, regarding the accuracy of estimated angle information obtained from this sensor, it is reported that it is likely affected by velocity.

Objective: The present study investigated the reliability and validity of the angle information obtained using IMU-based sensors compared with a three-dimensional (3D) motion analyzer.

Methods: The Euler angle obtained using the 3D motion analyzer and the angle obtained using the IMU-based sensor (IMU angle) were compared. Reliability was assessed by comparing the Bland-Altman analysis, intra-class correlation coefficient (ICC) (1,1), and cross-correlation function. The root mean square (RMS) error, ICC (2,1), and cross-correlation function were used to compare data on the Euler and IMU angles to evaluate the validity.

Results: Regarding reliability, the Bland-Atman analysis indicated no fixed or proportional bias in the angle measurements. The measurement errors ranged from 0.2° to 3.2°. In the validity, the RMS error ranged from 0.3° to 2.2°. The ICCs (2,1) were 0.9. The cross-correlation functions were >0.9, which indicated a high degree of agreement.

Conclusion: The IMU-based sensor had a high reliability and validity. The IMU angle may be used in rehabilitation.

背景:基于惯性测量单元(IMU)的运动传感器价格低廉,适合用于康复训练。然而,据报道,从这种传感器获得的估计角度信息的准确性很可能受到速度的影响:本研究对使用基于 IMU 的传感器和三维(3D)运动分析仪获得的角度信息的可靠性和有效性进行了比较:方法:比较使用三维运动分析仪获得的欧拉角和使用基于 IMU 的传感器获得的角度(IMU 角度)。通过比较 Bland-Altman 分析、类内相关系数 (ICC) (1,1) 和交叉相关函数来评估可靠性。均方根误差、ICC (2,1) 和交叉相关函数用于比较欧拉角和 IMU 角的数据,以评估有效性:关于可靠性,布兰德-阿特曼分析表明角度测量没有固定或比例偏差。测量误差在 0.2° 至 3.2° 之间。在有效性方面,均方根误差介于 0.3°至 2.2°之间。ICCs (2,1) 为 0.9。交叉相关函数大于 0.9,表明一致性很高:基于 IMU 的传感器具有很高的可靠性和有效性。结论:基于 IMU 的传感器具有较高的可靠性和有效性,IMU 角度可用于康复治疗。
{"title":"Reliability and validity of estimated angles information assessed using inertial measurement unit-based motion sensors.","authors":"Taiki Morikawa, Nariyuki Mura, Toshiaki Sato, Hiroshi Katoh","doi":"10.3233/BME-240031","DOIUrl":"10.3233/BME-240031","url":null,"abstract":"<p><strong>Background: </strong>Inertial measurement unit (IMU)-based motion sensors are affordable, and their use is appropriate for rehabilitation. However, regarding the accuracy of estimated angle information obtained from this sensor, it is reported that it is likely affected by velocity.</p><p><strong>Objective: </strong>The present study investigated the reliability and validity of the angle information obtained using IMU-based sensors compared with a three-dimensional (3D) motion analyzer.</p><p><strong>Methods: </strong>The Euler angle obtained using the 3D motion analyzer and the angle obtained using the IMU-based sensor (IMU angle) were compared. Reliability was assessed by comparing the Bland-Altman analysis, intra-class correlation coefficient (ICC) (1,1), and cross-correlation function. The root mean square (RMS) error, ICC (2,1), and cross-correlation function were used to compare data on the Euler and IMU angles to evaluate the validity.</p><p><strong>Results: </strong>Regarding reliability, the Bland-Atman analysis indicated no fixed or proportional bias in the angle measurements. The measurement errors ranged from 0.2° to 3.2°. In the validity, the RMS error ranged from 0.3° to 2.2°. The ICCs (2,1) were 0.9. The cross-correlation functions were >0.9, which indicated a high degree of agreement.</p><p><strong>Conclusion: </strong>The IMU-based sensor had a high reliability and validity. The IMU angle may be used in rehabilitation.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"439-450"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Bio-medical materials and engineering
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