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Simulation-guided development of advanced PID control algorithm for skin cooling in radiofrequency lipolysis 射频溶脂中皮肤冷却高级 PID 控制算法的模拟指导开发
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-02-21 DOI: 10.3233/bme-230185
Binyu Wang, Lianru Zang, Yingxi Lu, Mengying Zhan, Tingting Sun, Yu Zhou, Chengli Song
BACKGROUND:The clinical outcomes of bipolar radiofrequency (RF) lipolysis, a prevalent non-invasive fat reduction procedure, hinge on the delicate balance between effective lipolysis and patient safety, with skin overheating and subsequent tissue damage as primary concerns. OBJECTIVE:This study aimed to investigate a novel bipolar radiofrequency lipolysis technique, safeguarding the skin through an innovative PID temperature control algorithm. METHODS:Utilizing COMSOL Multiphysics simulation software, a two-dimensional fat and skin tissue model was established, simulating various PID temperature control schemes. The crux of the simulation involved a comparative analysis of different PID temperatures at 45 °C, 50 °C, and 55 °C and constant power strategies, assessing their implications on skin temperature. Concurrently, a custom bipolar radiofrequency lipolysis device was developed, with ex vivo experiments conducted using porcine tissue for empirical validation. RESULTS:The findings indicated that with PID settings of Kp = 7, Ki = 2, and Kd = 0, and skin temperature control at 45 °C or 50 °C, the innovative PID-based epidermal temperature control strategy successfully maintained the epidermal temperature within a safe range. This maintenance was achieved without compromising the effectiveness of RF lipolysis, significantly reducing the risk of thermal damage to the skin layers. CONCLUSION:Our research confirms the substantial practical utility of this advanced PID-based bipolar RF lipolysis technique in clinical aesthetic procedures, enhancing patient safety during adipose tissue ablation therapies.
背景:双极射频溶脂是一种流行的非侵入性减脂手术,其临床效果取决于有效溶脂和患者安全之间的微妙平衡,其中皮肤过热和随后的组织损伤是主要问题。目的:本研究旨在探讨一种新型双极射频溶脂技术,通过创新的 PID 温度控制算法保护皮肤。方法:利用 COMSOL Multiphysics 仿真软件,建立了一个二维脂肪和皮肤组织模型,模拟了各种 PID 温度控制方案。模拟的关键是对 45 ℃、50 ℃ 和 55 ℃ 的不同 PID 温度和恒定功率策略进行比较分析,评估它们对皮肤温度的影响。同时,还开发了一种定制的双极射频溶脂设备,并使用猪组织进行了体外实验,以进行经验验证。结果:研究结果表明,当 PID 设置为 Kp = 7、Ki = 2 和 Kd = 0,皮肤温度控制在 45 °C 或 50 °C 时,基于 PID 的创新表皮温度控制策略成功地将表皮温度控制在安全范围内。在保持温度的同时,不会影响射频溶脂的效果,大大降低了对皮肤层造成热损伤的风险。结论:我们的研究证实了这种先进的基于 PID 的双极射频溶脂技术在临床美容手术中的巨大实用价值,提高了脂肪组织消融治疗过程中的患者安全性。
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引用次数: 0
Lipid index to quantify the absorbed lipids in retrieved UHMWPE components of joint arthroplasty 用于量化关节成形术中超高分子量聚乙烯回收组件中吸收的脂质的脂质指数
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-24 DOI: 10.3233/bme-230183
Hideyuki Sakoda, Yusuke Tsuboko, Yoshihiro Okamoto, Eiichi Yamamoto, Takashi Imagama, Takashi Sakai, Hidetoshi Hamada, Nobuhiko Sugano
BACKGROUND:The ultra-high molecular weight polyethylene (UHMWPE) component of artificial joints is one of the most important factors affecting the clinical outcomes of joint arthroplasty. Although the possibility of in vivo UHMWPE degradation caused by absorbed lipids has been reported, a quantitative evaluation of this phenomenon has not yet been performed. OBJECTIVE:This study aimed to establish the lipid index (LI) as a quantitative indicator of the amount of absorbed lipids and the first step to quantify their effects on UHMWPE. METHODS:The LI was defined using the infrared spectrum obtained with a Fourier-transform infrared spectrophotometer and verified using the retrieved UHMWPE components. RESULTS:The LI was consistent with the amount of extract recovered in reflux extraction with hexane. In addition, the LI could replace lipid extraction for calculating the oxidation index (OI) because the value obtained by subtracting the LI from the OI showed good agreement with the OI obtained after lipid extraction. CONCLUSION:The LI represents the amount of lipids absorbed by UHMWPE and is useful for quantitatively evaluating the effects of lipids on UHMWPE. In addition, the LI enables OI measurements that are unaffected by absorbed lipids without requiring troublesome lipid-extraction procedures.
背景:人工关节的超高分子量聚乙烯(UHMWPE)组件是影响关节置换术临床效果的最重要因素之一。虽然有报道称吸收的脂质可能导致体内超高分子量聚乙烯降解,但尚未对这一现象进行定量评估。目的:本研究旨在确定脂质指数(LI),作为吸收脂质量的定量指标和量化脂质对超高分子量聚乙烯影响的第一步。方法:使用傅立叶变换红外分光光度计获得的红外光谱来定义脂质指数,并使用回收的超高分子量聚乙烯成分进行验证。结果:LI 与正己烷回流提取中回收的提取物量一致。此外,LI 可以代替脂质萃取来计算氧化指数(OI),因为从 OI 中减去 LI 后得到的值与脂质萃取后得到的 OI 非常一致。结论:LI 表示超高分子量聚乙烯吸收的脂质量,有助于定量评估脂质对超高分子量聚乙烯的影响。此外,LI 还能测量不受吸收脂质影响的 OI,而无需麻烦的脂质提取程序。
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引用次数: 0
Polyvinylpyrrolidone hydrogel coating for ureteral stent: Safety and performance evaluation 用于输尿管支架的聚乙烯吡咯烷酮水凝胶涂层:安全性和性能评估
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-23 DOI: 10.3233/bme-230179
Haibin Tang, Dimeng Wu, Zheng Liu, Xi Liu, Heng Yuan, Xiaosong Jin, Shuai Gao, Gang Chen
BACKGROUND:Ureteral stents are commonly used in urology. However, complications such as encrustation and infection on the surface of the stent, and injury to the ureteral mucosa can occur after implantation, causing discomfort for patients. OBJECTIVE:We intend to confirm the biosafety of polyvinylpyrrolidone (PVP) hydrophilic coating and its lubrication properties for surface modification of ureteral stents to reduce friction and improve patient comfort. METHODS:Based on our previous studies, we have developed a PVP hydrophilic coating for surface modification of ureteral stents. We firstly investigated the cytotoxicity, intradermal irritation, delayed type hypersensitivity, and acute systemic reactions of stent coating extracts. We further characterized the break strength, retention strength, and dynamic friction of the stent. RESULTS:The cell survival rate of all experimental groups was greater than 70%. No hypersensitivity reaction, systemic toxicity reaction, or obvious intradermal reaction were observed. The above results indicate that the test results of the modified stent meet the requirements of ISO 10993-5: 2009 (Cytotoxicity); ISO 10993-10:2021 (Sensitization and Irritation); ISO 10993-11:2017 (Acute Systemic Toxicity). After soaking in artificial urine for an extended period, there was no obvious change in its super-slip performance. CONCLUSION:Our results confirm the safety and lubrication characteristics of PVP hydrophilic coating for ureteral stent surface modification. The performance of this coating has the potential to reduce complications after stent implantation, thereby improving patient comfort, reducing medical burden, and has a good clinical application prospect.
背景:输尿管支架常用于泌尿外科。然而,植入后可能会出现支架表面结壳和感染、输尿管粘膜损伤等并发症,给患者带来不适。目的:我们打算证实聚乙烯吡咯烷酮(PVP)亲水涂层的生物安全性及其润滑特性,用于输尿管支架的表面改性,以减少摩擦,提高患者的舒适度。方法:在以往研究的基础上,我们开发了一种用于输尿管支架表面改性的 PVP 亲水涂层。我们首先研究了支架涂层提取物的细胞毒性、皮内刺激性、迟发型超敏反应和急性全身反应。我们还进一步测定了支架的断裂强度、保持强度和动态摩擦力。结果:所有实验组的细胞存活率均大于 70%。未观察到超敏反应、全身毒性反应或明显的皮内反应。上述结果表明,改良支架的测试结果符合 ISO 10993-5:2009(细胞毒性)、ISO 10993-10:2021(致敏性和刺激性)、ISO 10993-11:2017(急性全身毒性)的要求。在人工尿液中长时间浸泡后,超滑性能没有明显变化。结论:我们的研究结果证实了用于输尿管支架表面改性的 PVP 亲水涂层的安全性和润滑特性。该涂层的性能有望减少支架植入后的并发症,从而提高患者的舒适度,减轻医疗负担,具有良好的临床应用前景。
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引用次数: 0
Customized design and biomechanical property analysis of 3D-printed tantalum intervertebral cages 3D 打印钽椎间笼的定制设计和生物力学特性分析
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-10 DOI: 10.3233/bme-230154
Yutao Zhang, Shu Du, Wurikaixi Aiyiti, Yong Teng, Ru Jia, Houfeng Jiang
BACKGROUND:Intervertebral cages used in clinical applications were often general products with standard specifications, which were challenging to match with the cervical vertebra and prone to cause stress shielding and subsidence. OBJECTIVE:To design and fabricate customized tantalum (Ta) intervertebral fusion cages that meets the biomechanical requirements of the cervical segment. METHODS:The lattice intervertebral cages were customized designed and fabricated by the selective laser melting. The joint and muscle forces of the cervical segment under different movements were analyzed using reverse dynamics method. The stress characteristics of cage, plate, screws and vertebral endplate were analyzed by finite element analysis. The fluid flow behaviors and permeability of three lattice structures were simulated by computational fluid dynamics. Compression tests were executed to investigate the biomechanical properties of the cages. RESULTS:Compared with the solid cages, the lattice-filled structures significantly reduced the stress of cages and anterior fixation system. In comparison to the octahedroid and quaddiametral lattice-filled cages, the bitriangle lattice-filled cage had a lower stress shielding rate, higher permeability, and superior subsidence resistance ability. CONCLUSION:The inverse dynamics simulation combined with finite element analysis is an effective method to investigate the biomechanical properties of the cervical vertebra during movements.
背景:临床应用中使用的椎间融合保持架通常是标准规格的普通产品,与颈椎匹配具有挑战性,容易造成应力屏蔽和下沉。目的:设计和制造符合颈椎段生物力学要求的定制钽(Ta)椎间融合保持架。方法:通过选择性激光熔化技术设计并制造出定制的钽(Ta)椎间融合保持架。采用反向动力学方法分析了不同运动下颈椎节段的关节力和肌肉力。采用有限元分析方法分析了椎体笼、椎板、螺钉和椎体终板的应力特性。通过计算流体动力学模拟了三种晶格结构的流体流动行为和渗透性。通过压缩试验研究了椎体保持架的生物力学特性。结果:与实心保持架相比,格状填充结构大大降低了保持架和前固定系统的应力。与八面体和四面体格状填充保持架相比,位三角形格状填充保持架的应力屏蔽率更低,渗透性更高,抗下沉能力更强。结论:反动力学模拟结合有限元分析是研究颈椎运动时生物力学特性的有效方法。
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引用次数: 0
Antibacterial effect of Ag-containing hydroxyapatite thin film fabricated by sputtering 用溅射法制造的含银羟基磷灰石薄膜的抗菌效果
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-04 DOI: 10.3233/bme-230131
K. Ozeki, Y. Nakajima
BACKGROUND:Infections related to joint prosthesis are still a major concern for orthopedic surgeons. Hydroxyapatite (HA) is a useful biocompatible material because of its good osteocompatibility. Antibacterial HA coatings have been fabricated with addition of antibacterial agents such as Ag to HA using the plasma spraying method. However, the plasma-sprayed HA coating suffers from fractures at large thicknesses. The sputter-coated HA thin film has a high density, and has been applied clinically for dental implants. However, there are no extensive studies on Ag-containing HA thin films. OBJECTIVE:The aim of this study was to prepare an Ag-containing HA thin film by sputtering, and evaluate its antibacterial effect and cytotoxicity. METHODS:The Ag-containing HA thin films were prepared by radio-frequency magnetron sputtering. The films were characterized using X-ray photoelectron spectroscopy, X-ray diffractometry, and scanning electron microscopy (SEM). The antibacterial activities and cytotoxicities of the films were also evaluated. RESULTS:The Ag/Ca molar ratio of the films increased with the Ag ratio in the target. The SEM observation of the hydrothermally treated films showed surfaces covered with globular particles. All Ag-containing HA films exhibited an antibacterial effect against E. Coli. The number of cells of the films decreased with the Ag ratio. The films subjected to the hydrothermal treatment exhibited a higher number of cells than the as-sputtered films. CONCLUSION:The Ag-containing HA thin film was effective in terms of antibacterial effect, and had a low cytotoxicity in the proliferation of osteoblast cells at a low Ag ratio in the target.
背景:与关节假体有关的感染仍是整形外科医生关注的主要问题。羟基磷灰石(HA)具有良好的骨相容性,是一种有用的生物相容性材料。抗菌 HA 涂层是利用等离子喷涂法在 HA 中添加 Ag 等抗菌剂制成的。然而,等离子喷涂的 HA 涂层在厚度较大时会出现断裂。溅射涂层的 HA 薄膜具有高密度,已被临床应用于牙科植入物。然而,目前还没有关于含银 HA 薄膜的广泛研究。目的:本研究旨在通过溅射法制备含Ag的HA薄膜,并评估其抗菌效果和细胞毒性。方法:采用射频磁控溅射法制备含Ag的HA薄膜。利用 X 射线光电子能谱、X 射线衍射仪和扫描电子显微镜(SEM)对薄膜进行了表征。此外,还对薄膜的抗菌活性和细胞毒性进行了评估。结果:薄膜的Ag/Ca摩尔比随着靶材中Ag比例的增加而增加。水热处理薄膜的扫描电镜观察结果表明,薄膜表面覆盖着球状颗粒。所有含银的 HA 薄膜都对大肠杆菌有抗菌作用。薄膜上的细胞数量随含银量的增加而减少。经过水热处理的薄膜的细胞数要高于溅射薄膜。结论:含Ag的HA薄膜具有有效的抗菌效果,并且在低Ag比例的靶材中对成骨细胞的增殖具有较低的细胞毒性。
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引用次数: 0
Analysis of transjugular intrahepatic portosystemic shunt by hemodynamic simulation. 通过血液动力学模拟分析经颈静脉肝内门体分流术。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230020
Junjie Cao, Zhichao Yao, Guijun Huo, Zhanao Liu, Yao Tang, Jian Huang, Minxin Chen, Rui Ding, Liming Shen, Dayong Zhou

Background: Transjugular intrahepatic portosystemic shunt (TIPS), which artificially creates a portocaval shunt to reduce portal venous pressure, has gradually become the primary treatment for portal hypertension (PH). However, there is no prefect shunting scheme in TIPS to balance the occurrence of postoperative complications and effective haemostasis.

Objective: To construct cirrhotic PH models and compare different shunting schemes in TIPS.

Methods: Three cases of cirrhotic PH with different liver volumes were selected for enhanced computed tomography scanning. The models for different shunting schemes were created using Mimics software, and following FLUENT calculation, all the models were imported into the software computational fluid dynamic-post for processing. In each shunting scheme, the differences in portal vein pressure, hepatic blood perfusion and blood flow from the superior mesenteric vein in the shunt tract were compared. The coefficient G was adapted to evaluate the advantages and disadvantages.

Results: (1) Concerning the precise location of the shunt tract, the wider the diameter of the shunt tract, the lower the pressure of the portal vein and the lesser the hepatic blood perfusion. Meanwhile, the pressure drop objective was not achieved with the 6 mm-diameter shunting scheme. (2) The 8 mm-diameter shunting scheme through the left portal vein (LPV) had the highest coefficient G.

Conclusion: The 8 mm-diameter shunting scheme through the LPV may demonstrate a superior effect and prognosis in TIPS procedures.

背景:经颈静脉肝内门体分流术(TIPS)通过人工建立门腔分流以降低门静脉压力,已逐渐成为门静脉高压症(PH)的主要治疗方法。然而,TIPS尚无完美的分流方案来平衡术后并发症的发生和有效止血:构建肝硬化 PH 模型并比较 TIPS 的不同分流方案:方法:选择三例肝脏体积不同的肝硬化 PH 病例进行增强计算机断层扫描。使用 Mimics 软件创建不同分流方案的模型,经过 FLUENT 计算后,将所有模型导入计算流体力学-后处理软件进行处理。在每种分流方案中,比较了门静脉压力、肝血流灌注和分流道中肠系膜上静脉血流的差异。结果:(1) 关于分流道的精确位置,分流道直径越宽,门静脉压力越低,肝血流灌注越少。同时,直径为 6 毫米的分流方案无法实现压降目标。(2) 通过左门静脉(LPV)的 8 毫米直径分流方案的 G 系数最高:结论:通过 LPV 的 8 毫米直径分流方案在 TIPS 手术中可能显示出更优越的效果和预后。
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引用次数: 0
Rapidly degradable konjac glucomannan hydrogels cross-linked with olsalazine for colonic drug release. 与奥萨拉嗪交联的可快速降解魔芋葡甘露聚糖水凝胶用于结肠药物释放。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230066
Qiao Zhang, Huili Fu, Yunfei Zhang, Liang Li, Guoping Yan

Background: Polysaccharide hydrogel is one of the most important materials for the colon target drug release system. However, the degradation time of polysaccharide hydrogel is much longer than the retention time in the colon. The drugs are expelled from the body before being released.

Objective: In order to match the degradation of drug carriers and their retention time in the colon, a rapidly degradable konjac glucomannan (KGM) hydrogel was designed for colon target drug release.

Methods: A crosslinker containing azo bond, olsalazine, was used to prepare the rapidly degradable KGM hydrogel. The degradation and drug release of the hydrogels with different crosslinking densities in the normal buffer and the human fecal medium were studied to evaluate the efficiency of colon drug release.

Results: More than 50% of the KGM hydrogel by weight was degraded and more than 60% of the 5-fluorouracil (5-Fu) was released within 48 h in 5% w/v human fecal medium.

Conclusion: The drug was released more rapidly in a simulated colon environment than in a normal buffer. Furthermore, the drug release was controlled by the degradation of the hydrogel. The KGM hydrogel containing azo crosslinker has great potential for colon drug release.

背景:多糖水凝胶是结肠靶向药物释放系统最重要的材料之一。然而,多糖水凝胶的降解时间远远长于药物在结肠中的滞留时间。因此,药物在释放前会被排出体外:为了使药物载体的降解和在结肠中的保留时间相匹配,我们设计了一种可快速降解的魔芋葡甘露聚糖(KGM)水凝胶,用于结肠靶向药物释放:方法:使用含偶氮键的交联剂奥萨拉嗪制备可快速降解的魔芋葡甘露聚糖(KGM)水凝胶。研究了不同交联密度的水凝胶在正常缓冲液和人体粪便培养基中的降解和药物释放情况,以评估结肠药物释放的效率:以重量计,超过50%的KGM水凝胶在5% w/v的人类粪便培养基中降解,超过60%的5-氟尿嘧啶(5-Fu)在48小时内释放:结论:与普通缓冲液相比,药物在模拟结肠环境中的释放速度更快。此外,药物的释放受水凝胶降解的控制。含有偶氮交联剂的 KGM 水凝胶在结肠药物释放方面具有很大的潜力。
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引用次数: 0
Spatial preference behavior of robo-pigeons induced by electrical stimulus targeting fear nuclei. 以恐惧核为目标的电刺激诱发机器人鸽的空间偏好行为
IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-01-01 DOI: 10.3233/BME-240048
Yanna Ping, Huanhuan Peng, Yongjun Zhu, Yuhao Feng, Yexin Zhang, Xiaomin Qi, Xinyu Liu

Background: Numerous studies have confirmed that stimulating the mid-brain motor nuclei can regulate movement forcibly for robo-pigeons, but research on behavior modulation using non-motor nuclei is scarce.

Objective: In this study, we constructed a spatial preference behavior by stimulating the stratum griseum periventriculare (SGP), a nucleus correlated with fear and escape, for robo-pigeons.

Methods: The study was carried out in a square-enclosed experimental field, with a designated box serving as the 'safe' area for the robo-pigeons. If the robo-pigeon exits this area, the SGP will be stimulated. After a brief training period, the robo-pigeons will have a clear spatial preference for the box.

Results: The result from five pigeons has shown that, after simple training, the animals develop a spatial preference for the box. They can quickly return to the box in any situation when the SGP is stimulated, with a success rate exceeding 80% (89.0 ± 6.5%). Moreover, this behavior is highly stable and remains consistent, unaffected by changes in the location of the box or the interference box.

Conclusion: The results prove that using the electrical stimulus could enable animals to accomplish more complex tasks. It may offer a novel approach to regulating pigeon behavior and further advance the study of cyborg animals.

背景:大量研究证实,刺激中脑运动核团可以强制调节机器鸽的运动,但利用非运动核团调节行为的研究却很少:本研究中,我们通过刺激与恐惧和逃跑相关的脑室周围灰质层(SGP),为机器鸽构建了一种空间偏好行为:研究在一个方形封闭的实验场地中进行,实验场地中有一个指定的盒子作为机器鸽的 "安全 "区域。如果机器鸽离开这个区域,SGP 就会受到刺激。经过短暂的训练后,机器鸽会对盒子产生明显的空间偏好:五只鸽子的训练结果表明,经过简单的训练后,鸽子会对盒子产生空间偏好。在任何情况下,当刺激 SGP 时,它们都能迅速返回盒子,成功率超过 80%(89.0 ± 6.5%)。此外,这种行为还具有高度稳定性和连贯性,不受盒子位置或干扰盒变化的影响:结果证明,使用电刺激可以使动物完成更复杂的任务。这可能为调节鸽子行为提供了一种新方法,并进一步推动了对半机械动物的研究。
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引用次数: 0
Aloe vera mucilage loaded gelatin electrospun fibers contained in polylactic acid coaxial system and polylactic acid and poly(e-caprolactone) tri-layer membranes for tissue engineering. 用于组织工程的聚乳酸同轴系统和聚乳酸与聚(e-己内酯)三层膜所含的芦荟粘液负载明胶电纺纤维。
IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2024-01-01 DOI: 10.3233/BME-240050
María Mónica Castillo Ortega, Jesús Manuel Quiroz Castillo, Teresa Del Castillo Castro, Dora Evelia Rodriguez Felix, Hisila Del Carmen Santacruz Ortega, Octavio Manero, Karla Alejandra Lopez Gastelum, Lerma Hanaiy Chan Chan, Diego Hernandez Martinez, Jose Agustin Tapia Hernández, Damian Francisco Plascencia Martínez

Background: Polymeric electrospun mats have been used as scaffolds in tissue engineering for the development of novel materials due to its characteristics. The usage of synthetic materials has gone in decline due to environmental problems associated with their synthesis and waste disposal. Biomaterials such as biopolymers have been used recently due to good compatibility on biological applications and sustainability.

Objective: The purpose of this work is to obtain novel materials based on synthetic and natural polymers for applications on tissue engineering.

Methods: Aloe vera mucilage was obtained, chemically characterized, and used as an active compound contained in electrospun mats. Polymeric scaffolds were obtained in single, coaxial and tri-layer structures, characterized and evaluated in cell culture.

Results: Mucilage loaded electrospun fibers showed good compatibility due to formation of hydrogen bonds between polymers and biomolecules from its structure, evidenced by FTIR spectra and thermal properties. Cell viability test showed that most of the obtained mats result on viability higher than 75%, resulting in nontoxic materials, ready to be used on scaffolding applications.

Conclusion: Mucilage containing fibers resulted on materials with potential use on scaffolding applications due to their mechanical performance and cell viability results.

背景:聚合物电纺垫因其特性被用作组织工程中的支架,用于开发新型材料。由于合成材料的合成和废物处理所带来的环境问题,合成材料的使用已日渐减少。生物材料(如生物聚合物)由于在生物应用方面具有良好的兼容性和可持续性,最近得到了广泛应用:这项工作的目的是获得基于合成和天然聚合物的新型材料,用于组织工程:方法:获得芦荟粘液,对其进行化学表征,并将其用作电纺垫中的活性化合物。获得了单层、同轴和三层结构的聚合物支架,并对其进行了表征和细胞培养评估:傅立叶变换红外光谱和热性能表明,由于聚合物和生物大分子之间形成氢键,粘液负载电纺纤维显示出良好的兼容性。细胞存活率测试表明,获得的大多数纤维毡的存活率高于 75%,因此是无毒材料,可用于支架应用:结论:由于其机械性能和细胞存活率结果,含黏液纤维的材料具有支架应用的潜力。
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引用次数: 0
Enhanced mechanic properties of calcium phosphate cements via mussel-inspired adhesive as bone substitute: Highlights of their interactions. 通过贻贝启发粘合剂作为骨替代物增强磷酸钙水门汀的力学性能:它们之间相互作用的亮点。
IF 1 4区 医学 Q3 Engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230017
Rupan Yuan, Sijie Zhou, Xiong Xiong, Dan Yang, Donghu Lin, Taiyi Li, Bin He, Guihua Wei, Shuxin Qu

Background: Inspired by natural bones, many organic components were added to Calcium Phosphate Cements (CPCs) to improve their mechanical strength. However, the strength of these composite CPCs is limited by the low strength of organic components itself and the weak interaction between organic components and CPCs.

Objective: Firstly, a composite CPC containing mussel-inspired adhesive, Poly-(Dopamine Methacrylamide-co-2-methoxy Ethylacrylate) (pDM) was developed. Secondly, the interactions between pDM and CPC and their effect on mechanical properties were investigated.

Methods: The interactions between pDM and CPC were performed by Nuclear Magnetic Resonance, Laser Raman, X-ray Photoelectron Spectroscopy, Fourier Transform-Infrared Spectroscopy and X-ray Diffraction Analysis.

Results: The toughness and compressive strength of pDM-CPC scaffold were both significantly enhanced, because of the enhanced interface binding strength among CPC and pDM due to their interaction and the improved mechanical strength of pDM owing to its self-oxidation cross-linking. The toughness of pDM-CPC scaffolds increased with the increased contents of pDM, while pDM-CPC scaffold containing 35 wt.% pDM had the highest compressive strength of all, which the latter was more than five times compared to that of CPC.

Conclusion: The mechanically strong pDM-CPC scaffolds has potential application in bone regeneration as well as in craniofacial and orthopedic repair.

背景:受天然骨骼的启发,许多有机成分被添加到磷酸钙水泥(CPC)中,以提高其机械强度。然而,这些复合 CPC 的强度受到有机成分本身强度低以及有机成分与 CPC 之间相互作用弱的限制:首先,开发了一种含有贻贝启发粘合剂聚多巴胺甲基丙烯酰胺-2-甲氧基乙基丙烯酸酯(pDM)的复合 CPC。其次,研究了 pDM 与 CPC 之间的相互作用及其对机械性能的影响:方法:采用核磁共振、激光拉曼、X 射线光电子能谱、傅立叶变换红外光谱和 X 射线衍射分析法研究 pDM 与 CPC 之间的相互作用:结果:pDM-CPC 支架的韧性和抗压强度均显著提高,这是由于 CPC 和 pDM 之间的相互作用增强了界面结合强度,而 pDM 的自氧化交联又提高了机械强度。pDM-CPC 支架的韧性随着 pDM 含量的增加而增加,而含有 35 wt.% pDM 的 pDM-CPC 支架的抗压强度最高,是 CPC 支架的五倍多:结论:机械强度高的 pDM-CPC 支架在骨再生以及颅面和骨科修复中具有潜在的应用价值。
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引用次数: 0
期刊
Bio-medical materials and engineering
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