Collagen is an essential protein in connective tissue, widely used as a bioactive. Raw collagen is obtained from cattle, buffalo, and pigs with problems spreading infectious animal diseases. Collagen can be obtained from waste milkfish (Chanos chanos) scales as an alternative source of mammal raw materials. This study aims to determine the acetic acid's most effective concentration and maceration time in isolating collagen from milkfish scales based on the preservative and emulsifying determination. This research is quasi-experimental design by testing the isolated collagen against collagen yield, proximate analysis of collagen, pH test, preservative test, and analysis of emulsifier substances. The results of the isolation of collagen in all treatment groups had emulsifying and preservative abilities, where a concentration of 0.5 M acetic acid with a maceration time of 72 hours produced the most effective collagen as an emulsifier based on the results of the emulsion stability test and emulsion layer boundary test, as well as at the concentration of 0, acetic acid 5 M with variations in maceration time of 48 hours and 72 hours produced the most effective collagen as a preservative.
{"title":"Development Of Raw Collagen From Waste Mılkfısh (Chanos chanos) Scales As A Preservatıve And Emulsıfyıng Agents","authors":"Sudrajat Sugiharta, Euis Prihatini, Iin Lidia Putama Mursal","doi":"10.57174/jborn.v3i1.75","DOIUrl":"https://doi.org/10.57174/jborn.v3i1.75","url":null,"abstract":"Collagen is an essential protein in connective tissue, widely used as a bioactive. Raw collagen is obtained from cattle, buffalo, and pigs with problems spreading infectious animal diseases. Collagen can be obtained from waste milkfish (Chanos chanos) scales as an alternative source of mammal raw materials. This study aims to determine the acetic acid's most effective concentration and maceration time in isolating collagen from milkfish scales based on the preservative and emulsifying determination. This research is quasi-experimental design by testing the isolated collagen against collagen yield, proximate analysis of collagen, pH test, preservative test, and analysis of emulsifier substances. The results of the isolation of collagen in all treatment groups had emulsifying and preservative abilities, where a concentration of 0.5 M acetic acid with a maceration time of 72 hours produced the most effective collagen as an emulsifier based on the results of the emulsion stability test and emulsion layer boundary test, as well as at the concentration of 0, acetic acid 5 M with variations in maceration time of 48 hours and 72 hours produced the most effective collagen as a preservative.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85896033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension is a global health problem often encountered, and the appropriate use of antihypertensive drugs is very important for optimal blood pressure control. Therefore, it is necessary to research the description of the use of antihypertensive drugs in various health facilities. The purpose of this study was to describe the prescription of antihypertensive drugs in patients at "X" hospital in the outpatient department. The research data obtained were digital data from prescription services from January-December 2022. This study used retrospective data by accessing computer service data at the "X" hospital outpatient pharmacy to track the history of past hypertensive patients’ treatment. The sampling technique used is total sampling. The results showed that the most prescribed antihypertensive drugs were amlodipine, with 13,203 prescription items. Bisoprolol with 10,704 prescription items, and candesartan with 9,885 prescription items. The frequency of prescribing the antihypertensive drug class the most was calcium channel blockers, as much as 13,784 (23.41%), while for the drug class which was the least prescribed, namely alpha-2 agonists, there were 68 drugs (0.12%). Based on the study results, it can be concluded that the most widely prescribed antihypertensive drugs at the outpatient pharmacy at "X" hospital are amlodipine, bisoprolol, and candesartan.
{"title":"An Overview of the Use of Antihypertensive Drugs at the Outpatient Pharmacy of Tarakan \"X\" Hospital in 2022","authors":"Benyamin, S. Syuhada, Benazir Evita Rukaya","doi":"10.57174/j.born.v3i1.81","DOIUrl":"https://doi.org/10.57174/j.born.v3i1.81","url":null,"abstract":"Hypertension is a global health problem often encountered, and the appropriate use of antihypertensive drugs is very important for optimal blood pressure control. Therefore, it is necessary to research the description of the use of antihypertensive drugs in various health facilities. The purpose of this study was to describe the prescription of antihypertensive drugs in patients at \"X\" hospital in the outpatient department. The research data obtained were digital data from prescription services from January-December 2022. This study used retrospective data by accessing computer service data at the \"X\" hospital outpatient pharmacy to track the history of past hypertensive patients’ treatment. The sampling technique used is total sampling. The results showed that the most prescribed antihypertensive drugs were amlodipine, with 13,203 prescription items. Bisoprolol with 10,704 prescription items, and candesartan with 9,885 prescription items. The frequency of prescribing the antihypertensive drug class the most was calcium channel blockers, as much as 13,784 (23.41%), while for the drug class which was the least prescribed, namely alpha-2 agonists, there were 68 drugs (0.12%). Based on the study results, it can be concluded that the most widely prescribed antihypertensive drugs at the outpatient pharmacy at \"X\" hospital are amlodipine, bisoprolol, and candesartan.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81378590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sriargianti amir Argi, Apriorita Apriorita, Rohandi Baharuddin, Satria Hanggara Putra
Perawatan payudara merupakan suatu intervensi yang penting dilakukan pada masa kehamilan sebagai persiapan dalam proses menyusui setelah melahirkan. Berdasarkan hasil studi pendahuluan bahwa sebagian ibu kurang mengetahui tentang cara perawatan payudara. Tujuan penelitian ini adalah untuk mengetahui gambaran pengetahuan ibu hamil tentang perawatan payudara selama kehamilan. Metode penelitian ini merupakan metode penelitian deskriptif, pengambilan sampel secara non-probability sampling menggunakan teknik accindental sampling dengan jumlah sampel 50 yang sesuai dengan kriteria inklusi dan eksklusi. Teknik pengumpulan data menggunakan kuesioner yang berkaitan dengan pengetahuan perawatan payudara. Hasil penelitian menunjukkan karakteristik responden berdasarkan usia tertinggi yaitu usia 20-35 tahun sebanyak 25 (50,0%) responden, berdasarkan pekerjaan terbanyak didapatkan IRT sebanyak 31 (62,0%) responden, berdasarkan paritas didapatkan jumlah tertinggi dan multipara sebanyak 28 (56,0%) responden, berdasarkan pendidikan didapatkan hasil terbanyak yaitu SMA sebanyak 22 (44,0%), berdasarkan pengetahuan didapatkan hasil pengetahuan baik sebanyak 6 (12,0%), cukup sebanyak 16 (32,0%), dan kurang sebanyak 28 (56,0%) responden. Kesimpulan penelitian ini menunjukkan sebagian besar ibu menyusui di Puskesmas Karang Rejo kota Tarakan adalah berpengetahuan kurang terkait perawatan payudara selama kehamilan.
{"title":"Gambaran Pengetahuan Ibu Hamil tentang Perawatan Payudara Selama Kehamilan di Puskesmas Karang Rejo Tarakan","authors":"Sriargianti amir Argi, Apriorita Apriorita, Rohandi Baharuddin, Satria Hanggara Putra","doi":"10.57174/jborn.v3i1.64","DOIUrl":"https://doi.org/10.57174/jborn.v3i1.64","url":null,"abstract":"Perawatan payudara merupakan suatu intervensi yang penting dilakukan pada masa kehamilan sebagai persiapan dalam proses menyusui setelah melahirkan. Berdasarkan hasil studi pendahuluan bahwa sebagian ibu kurang mengetahui tentang cara perawatan payudara. Tujuan penelitian ini adalah untuk mengetahui gambaran pengetahuan ibu hamil tentang perawatan payudara selama kehamilan. Metode penelitian ini merupakan metode penelitian deskriptif, pengambilan sampel secara non-probability sampling menggunakan teknik accindental sampling dengan jumlah sampel 50 yang sesuai dengan kriteria inklusi dan eksklusi. Teknik pengumpulan data menggunakan kuesioner yang berkaitan dengan pengetahuan perawatan payudara. Hasil penelitian menunjukkan karakteristik responden berdasarkan usia tertinggi yaitu usia 20-35 tahun sebanyak 25 (50,0%) responden, berdasarkan pekerjaan terbanyak didapatkan IRT sebanyak 31 (62,0%) responden, berdasarkan paritas didapatkan jumlah tertinggi dan multipara sebanyak 28 (56,0%) responden, berdasarkan pendidikan didapatkan hasil terbanyak yaitu SMA sebanyak 22 (44,0%), berdasarkan pengetahuan didapatkan hasil pengetahuan baik sebanyak 6 (12,0%), cukup sebanyak 16 (32,0%), dan kurang sebanyak 28 (56,0%) responden. Kesimpulan penelitian ini menunjukkan sebagian besar ibu menyusui di Puskesmas Karang Rejo kota Tarakan adalah berpengetahuan kurang terkait perawatan payudara selama kehamilan.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82961370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Induksi anestesi setiap pasien bisa mendapatkan premedikasi yang bervariasi. Pemilihan obat anestesi sebaiknya berdasarkan karakteristik pasien dan kondisi yang berhubungan dengan operasi dan biaya. Penelitian ini bertujuan untuk mendeskripsikan penggunaan obat anestesi di Instalasi Bedah RSI PKU Muhammadiyah Pekajangan pada periode bulan Mei-Juli 2022. Metode yang digunakan dalam penelitian ini yaitu deskriptif observasional. Dari hasil penelitian menunjukkan penggunaan fentanyl 100 mcg/2mL 130 (27,43%), recofol-N 10 mg/mL 101 (21,31%), KTM 100 mg/mL 89 (18,78%), sevodex 250 mL 50 (10,55%), sedacum 5 mg/5mL 39 (8,23%), tramus 25 mg 38 (8,02%), tramus 50 mg 14 (2,95%), dan isorane/isoflurane 250 mL 13 (2,74%). Sehingga dapat disimpulkan penggunaan obat anestesi umum yang paling banyak digunakan adalah fentanyl 100 mcg/2mL sebesar 27,43%.
{"title":"Gambaran Penggunaan Obat Anestesi di Instalasi Bedah RSI PKU Muhammadiyah Pekajangan","authors":"Musa Fitri Fatkhiya, Nitya Rofiana Arrizka","doi":"10.57174/jborn.v3i1.71","DOIUrl":"https://doi.org/10.57174/jborn.v3i1.71","url":null,"abstract":"Induksi anestesi setiap pasien bisa mendapatkan premedikasi yang bervariasi. Pemilihan obat anestesi sebaiknya berdasarkan karakteristik pasien dan kondisi yang berhubungan dengan operasi dan biaya. Penelitian ini bertujuan untuk mendeskripsikan penggunaan obat anestesi di Instalasi Bedah RSI PKU Muhammadiyah Pekajangan pada periode bulan Mei-Juli 2022. Metode yang digunakan dalam penelitian ini yaitu deskriptif observasional. Dari hasil penelitian menunjukkan penggunaan fentanyl 100 mcg/2mL 130 (27,43%), recofol-N 10 mg/mL 101 (21,31%), KTM 100 mg/mL 89 (18,78%), sevodex 250 mL 50 (10,55%), sedacum 5 mg/5mL 39 (8,23%), tramus 25 mg 38 (8,02%), tramus 50 mg 14 (2,95%), dan isorane/isoflurane 250 mL 13 (2,74%). Sehingga dapat disimpulkan penggunaan obat anestesi umum yang paling banyak digunakan adalah fentanyl 100 mcg/2mL sebesar 27,43%.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90621305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salah satu kebutuhan penting bagi seorang wanita adalah kosmetik. Salah satu jenis kosmetik yang sering digunakan oleh remaja ataupun wanita dewasa ialah perona pipi (blush on). Perona pipi tersedia dalam berbagai macam warna, dan warna yang paling populer adalah warna merah. Beberepa produk kosmetik dikhawatirkan dapat mengandung zat pewarna merah yang membahayakan seperti rhodamin B. Adapun tujuan dari penelitian ini adalah untuk mengidentifikasi kandungan senyawa rhodamin B pada produk perona pipi yang beredar di Pasar Tradisional kota Tarakan. Metode penelitian ini adalah analisis kualitatif kandungan senyawa rhodamin B pada sampel dengan menggunakan Rapid Test Kit rhodamin B. Hasil penelitian menunjukkan dari 9 sampel perona pipi yang beredar di Pasar Tradisional kota Tarakan didapatkan 4 sampel perona pipi yang positif mengandung Rhodamin B, dari ke-4 sampel yang positif tersebut terdapat 2 sampel yang terdaftar dalam BPOM.
女人最需要的是化妆品。青少年或成年妇女最常用的化妆品之一是腮红。胭脂有很多种颜色，最受欢迎的颜色是红色。此外，这项研究的目的是确定市面上常用的腮红产品中存在的化合物含量。rhodamin化合物含量的定性研究方法是分析在用快速测试套件rhodamin样本中B B . 9胭脂样本的研究结果显示市场上流通的传统城市塔拉坎得到B 4含有rhodamin胭脂的样本呈阳性,阳性的样本第四BPOM中列出的两个样本。
{"title":"Analisis Kandungan Rhodamin B pada Produk Perona Pipi (Blush On) yang Beredar di Pasar Tradisional Kota Tarakan","authors":"P. Annisa, Irma Novrianti, Heriani Heriani","doi":"10.57174/j.born.v3i1.80","DOIUrl":"https://doi.org/10.57174/j.born.v3i1.80","url":null,"abstract":"Salah satu kebutuhan penting bagi seorang wanita adalah kosmetik. Salah satu jenis kosmetik yang sering digunakan oleh remaja ataupun wanita dewasa ialah perona pipi (blush on). Perona pipi tersedia dalam berbagai macam warna, dan warna yang paling populer adalah warna merah. Beberepa produk kosmetik dikhawatirkan dapat mengandung zat pewarna merah yang membahayakan seperti rhodamin B. Adapun tujuan dari penelitian ini adalah untuk mengidentifikasi kandungan senyawa rhodamin B pada produk perona pipi yang beredar di Pasar Tradisional kota Tarakan. Metode penelitian ini adalah analisis kualitatif kandungan senyawa rhodamin B pada sampel dengan menggunakan Rapid Test Kit rhodamin B. Hasil penelitian menunjukkan dari 9 sampel perona pipi yang beredar di Pasar Tradisional kota Tarakan didapatkan 4 sampel perona pipi yang positif mengandung Rhodamin B, dari ke-4 sampel yang positif tersebut terdapat 2 sampel yang terdaftar dalam BPOM.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84679849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agus Amanda Defi Rahayu, Jufri Ubrusun, Irma Novrianti
Jajanan “tusuk-tusuk” merupakan salah satu makanan yang digemari oleh semua kalangan, dengan rasa yang enak dan biasanya disajikan dengan menambahkan saus. Rhodamin B salah satu zat pewarna sintetik yang digunakan ada industri tekstil. Sering kali pedagang nakal menggunakan Rhodamin B pada makanan yang dijual untuk mempercantik warna makanan tersebut. Seperti yang diketahui Rhodamin B dapat menyebabkan iritasi pada mata, saluran pencernaan dan pernapasan. Penelitian ini bermaksud untuk meneliti ada atau tidak adanya identifikasi bahan berbahaya Rhodamin B dalam saus tomat jajanan “tusuk-tusuk” yang beredar di taman Berlabuh dan taman Oval kota Tarakan. Saus masing-masing diperoleh dari jajanan “tusuk-tusuk” yang beredar di taman Berlabuh dan Taman Oval Tarakan. Penelitian yang dilakukan dan diperoleh 10 sampel yang beredar di taman Berlabuh dan Taman Oval, lalu setiap sampel ditimbang sebanyak 25 gram dan dilarutkan sampel tersebut dengan aquadest yang telah dipanaskan. Setelah itu sampel diuji dengan menggunakan metode uji cepat (Rapid test kit). Hasil penelitian ini menunjukkan bahwa dari 10 sampel saus jajanan “tusuk-tusuk” di Taman Berlabuh dan Taman Oval kota Tarakan tidak mengandung Rhodamin B.
{"title":"Ujı Kualıtatıf Rhodamın B pada Saus Jajanan \"Tusuk-Tusuk\" dı Taman Berlabuh dan Taman Oval kota Tarakan","authors":"Agus Amanda Defi Rahayu, Jufri Ubrusun, Irma Novrianti","doi":"10.57174/jborn.v3i1.79","DOIUrl":"https://doi.org/10.57174/jborn.v3i1.79","url":null,"abstract":"Jajanan “tusuk-tusuk” merupakan salah satu makanan yang digemari oleh semua kalangan, dengan rasa yang enak dan biasanya disajikan dengan menambahkan saus. Rhodamin B salah satu zat pewarna sintetik yang digunakan ada industri tekstil. Sering kali pedagang nakal menggunakan Rhodamin B pada makanan yang dijual untuk mempercantik warna makanan tersebut. Seperti yang diketahui Rhodamin B dapat menyebabkan iritasi pada mata, saluran pencernaan dan pernapasan. Penelitian ini bermaksud untuk meneliti ada atau tidak adanya identifikasi bahan berbahaya Rhodamin B dalam saus tomat jajanan “tusuk-tusuk” yang beredar di taman Berlabuh dan taman Oval kota Tarakan. Saus masing-masing diperoleh dari jajanan “tusuk-tusuk” yang beredar di taman Berlabuh dan Taman Oval Tarakan. Penelitian yang dilakukan dan diperoleh 10 sampel yang beredar di taman Berlabuh dan Taman Oval, lalu setiap sampel ditimbang sebanyak 25 gram dan dilarutkan sampel tersebut dengan aquadest yang telah dipanaskan. Setelah itu sampel diuji dengan menggunakan metode uji cepat (Rapid test kit). Hasil penelitian ini menunjukkan bahwa dari 10 sampel saus jajanan “tusuk-tusuk” di Taman Berlabuh dan Taman Oval kota Tarakan tidak mengandung Rhodamin B.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78725489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Rahmawati, Bayu Putra, L. Wiyani, Andi Maulana Kamri, S. Azahra
Diabetes mellitus is a metabolic disease characterized by increased blood glucose levels. Currently, the treatment of diabetes mellitus uses synthetic or chemical drugs and natural ingredients such as virgin coconut oil. Virgin coconut oil (VCO) is extracted with minimal heating and no chemical purification process. This study aims to obtain data on the impact of VCO as an antidiabetic obtained from several research journals. This literature study uses a narrative review method obtained from the Google Scholar, Pubmed, and Science Direct databases. The results of this study indicate that VCO can be used as an alternative to lowering blood glucose levels because it has antidiabetic activity. Medium-chain fatty acid (MCFA) lauric acid in VCO can stimulate insulin production in pancreatic beta cells. This study concludes that virgin coconut oil can potentially reduce blood sugar levels.
{"title":"Anti-diabetic Activity of Virgin Coconut Oil (VCO): Review","authors":"R. Rahmawati, Bayu Putra, L. Wiyani, Andi Maulana Kamri, S. Azahra","doi":"10.57174/j.born.v3i1.73","DOIUrl":"https://doi.org/10.57174/j.born.v3i1.73","url":null,"abstract":"Diabetes mellitus is a metabolic disease characterized by increased blood glucose levels. Currently, the treatment of diabetes mellitus uses synthetic or chemical drugs and natural ingredients such as virgin coconut oil. Virgin coconut oil (VCO) is extracted with minimal heating and no chemical purification process. This study aims to obtain data on the impact of VCO as an antidiabetic obtained from several research journals. This literature study uses a narrative review method obtained from the Google Scholar, Pubmed, and Science Direct databases. The results of this study indicate that VCO can be used as an alternative to lowering blood glucose levels because it has antidiabetic activity. Medium-chain fatty acid (MCFA) lauric acid in VCO can stimulate insulin production in pancreatic beta cells. This study concludes that virgin coconut oil can potentially reduce blood sugar levels.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87461944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Available synthetic antioxidants have been reported to have mutagenic and toxic effects. On the other hand, natural antioxidants show their superiority as they are not or less toxic. Passiflora foetida has the potential as an antioxidant, but the investigation of the antioxidant activity of the P. foetida chromatography column fraction has not been reported. This studied aims to investigate the antioxidant activity of the column chromatographic fractions of P. foetida leaves. An antioxidant assay using the DPPH and FRAP methods. The extraction was carried out by graded maceration, then fractionation using column chromatography. The antioxidant activity test was carried out using the DPPH and FRAP methods. Thin Layer Chromatography analysis was performed to determine the chromatogram pattern. The EC50 using DPPH method from n-hexane extract: 129.035 µg/mL, ethyl acetate extract: 206.398 µg/mL, methanol extract: 97.453 µg/mL, while the EC50 using FRAP method from n-hexane extract: 67.851 µg/mL, ethyl acetate extract : 68.981 µg/mL, and methanol extract: 58.787 µg/mL. Column chromatography fractions have antioxidant activity, with FMetPF6 as the fraction with the best activity, with percent inhibition 41.85±1.96 at concentration 25 µg/mL (DPPH), and with percent antioxidant activity 26.03±0.84 at concentration 9 µg/mL (FRAP). Passiflora foetida leaves have great potential as an antioxidant; both the extract and its fractions have antioxidant activity. The FMetPF6 has the best activity compare to other extracts and fractions. Further analysis to determine the various compounds in FMetPF6 using LC-MS/MS will facilitate the active compound's isolation.
{"title":"Column Chromatography Fractionation and Antioxidant Activity of Passiflora foetida Leaves","authors":"Nita Triadisti, I. Zamzani","doi":"10.33084/bjop.v6i1.1830","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.1830","url":null,"abstract":"Available synthetic antioxidants have been reported to have mutagenic and toxic effects. On the other hand, natural antioxidants show their superiority as they are not or less toxic. Passiflora foetida has the potential as an antioxidant, but the investigation of the antioxidant activity of the P. foetida chromatography column fraction has not been reported. This studied aims to investigate the antioxidant activity of the column chromatographic fractions of P. foetida leaves. An antioxidant assay using the DPPH and FRAP methods. The extraction was carried out by graded maceration, then fractionation using column chromatography. The antioxidant activity test was carried out using the DPPH and FRAP methods. Thin Layer Chromatography analysis was performed to determine the chromatogram pattern. The EC50 using DPPH method from n-hexane extract: 129.035 µg/mL, ethyl acetate extract: 206.398 µg/mL, methanol extract: 97.453 µg/mL, while the EC50 using FRAP method from n-hexane extract: 67.851 µg/mL, ethyl acetate extract : 68.981 µg/mL, and methanol extract: 58.787 µg/mL. Column chromatography fractions have antioxidant activity, with FMetPF6 as the fraction with the best activity, with percent inhibition 41.85±1.96 at concentration 25 µg/mL (DPPH), and with percent antioxidant activity 26.03±0.84 at concentration 9 µg/mL (FRAP). Passiflora foetida leaves have great potential as an antioxidant; both the extract and its fractions have antioxidant activity. The FMetPF6 has the best activity compare to other extracts and fractions. Further analysis to determine the various compounds in FMetPF6 using LC-MS/MS will facilitate the active compound's isolation.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76577176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. A. Ugbe, G. Shallangwa, A. Uzairu, I. Abdulkadir
Onchocerciasis is one of the major neglected tropical diseases caused by the filarial worm (Onchocerca volvulus), affecting an estimated population of about 37 million people living predominantly in tropical Africa. The major treatment approach has been based on the use of Ivermectin, which kills the microfilariae or the less effective Doxycycline targeting Wolbachia, endosymbiont of filarial nematodes. Flubendazole (FBZ) has proved effective in treating adult worms but with threatening adverse effects. Against this backdrop, therefore, a combined molecular docking study and pharmacokinetic screening were conducted on a series of benzimidazole-benzoxaborole hybrids to find more potent analogs with attributes that address the limitations of existing therapies. All the nineteen analogs were found to possess better docking scores than the reference drug (FBZ, Moldock scores = -120.466 and -125.359). The results of pharmacokinetic testing suggest that four molecules (14, 16, 19, and 20) are orally bioavailable and showed better ADMET properties than FBZ. These molecules and FBZ showed good binding interactions with the receptors’ active sites. Also, the molecular dynamic simulation performed on the docked complexes of 20 and FBZ confirmed the rigidity and stability of their interactions. Based on the results of this study, the selected molecules (especially 20) could be considered superior drug candidates for the treatment of Onchocerciasis.
{"title":"Molecular Docking Investigation, Pharmacokinetic Analysis, and Molecular Dynamic Simulation of Some Benzoxaborole-Benzimidazole Hybrids: An Approach to Identifying Superior Onchocerca Inhibitors","authors":"F. A. Ugbe, G. Shallangwa, A. Uzairu, I. Abdulkadir","doi":"10.33084/bjop.v6i1.3876","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.3876","url":null,"abstract":"Onchocerciasis is one of the major neglected tropical diseases caused by the filarial worm (Onchocerca volvulus), affecting an estimated population of about 37 million people living predominantly in tropical Africa. The major treatment approach has been based on the use of Ivermectin, which kills the microfilariae or the less effective Doxycycline targeting Wolbachia, endosymbiont of filarial nematodes. Flubendazole (FBZ) has proved effective in treating adult worms but with threatening adverse effects. Against this backdrop, therefore, a combined molecular docking study and pharmacokinetic screening were conducted on a series of benzimidazole-benzoxaborole hybrids to find more potent analogs with attributes that address the limitations of existing therapies. All the nineteen analogs were found to possess better docking scores than the reference drug (FBZ, Moldock scores = -120.466 and -125.359). The results of pharmacokinetic testing suggest that four molecules (14, 16, 19, and 20) are orally bioavailable and showed better ADMET properties than FBZ. These molecules and FBZ showed good binding interactions with the receptors’ active sites. Also, the molecular dynamic simulation performed on the docked complexes of 20 and FBZ confirmed the rigidity and stability of their interactions. Based on the results of this study, the selected molecules (especially 20) could be considered superior drug candidates for the treatment of Onchocerciasis.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84193991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Complex morphological and micromorphological studies have been made about bootjack bur (Bidens frondosa) growing on the territory of the Krasnodar region. The lamina is of dorsoventral type. The conduction system has fasciations, three closed collateral bundles, are present near the vein. The leaf is of amphistomatic type, stomatic apparats are present in a small amount. Anticlinical walls of the main cells of the epidermis are strongly flexuose. The lower epidermis if compared to the upper one has a large number of stomatic apparatus of anisocytic type. The trichomes are leggy, represented by multicellular hairs of different shapes and lengths. Micromorphological capabilities of bootjack bur’s transverse section of the caulis and leafstalk have been studied. Received micromorphological data is a fragment of complex pharmacognostic studies of the Bidens kind. For acquiring the anti-allergic medication in the future, it is necessary to make pharma-technological studies and come up with the necessary medical form in the shape of thick extract and also make pharmacological studies in acquiring this medical form.
{"title":"Morphological and Micromorphological Investigations of Bidens frondosa L. from Flora of Krasnodar Region, Russia","authors":"V. Zinchenko, Фатима Казбековна Серебряная","doi":"10.33084/bjop.v6i1.1554","DOIUrl":"https://doi.org/10.33084/bjop.v6i1.1554","url":null,"abstract":"Complex morphological and micromorphological studies have been made about bootjack bur (Bidens frondosa) growing on the territory of the Krasnodar region. The lamina is of dorsoventral type. The conduction system has fasciations, three closed collateral bundles, are present near the vein. The leaf is of amphistomatic type, stomatic apparats are present in a small amount. Anticlinical walls of the main cells of the epidermis are strongly flexuose. The lower epidermis if compared to the upper one has a large number of stomatic apparatus of anisocytic type. The trichomes are leggy, represented by multicellular hairs of different shapes and lengths. Micromorphological capabilities of bootjack bur’s transverse section of the caulis and leafstalk have been studied. Received micromorphological data is a fragment of complex pharmacognostic studies of the Bidens kind. For acquiring the anti-allergic medication in the future, it is necessary to make pharma-technological studies and come up with the necessary medical form in the shape of thick extract and also make pharmacological studies in acquiring this medical form.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83100389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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