Hyperlipidemia is a non-communicable disease (NCD) caused by several factors, such as a person's socioeconomic status, culture, customs, habits, and lifestyle. Through user interaction on social media, we can discover the model anti-hyperlipidemia by extracting information, complaints, suggestions, and calls for help about the treatment, which will play a role as an intervention to reduce hyperlipidemia in Indonesia. This study aimed to identify factors influencing perceptions of hyperlipidemia drugs and resulting sentiment on the social media platform Twitter. This study used user-uploaded tweet data to compare perceptions of hyperlipidemia drugs in 2020 and keywords for hyperlipidemia terms and medicine. Tweets related to anti-hyperlipidemia were extracted by issuing tweets containing advertisements, news, re-tweet, and content outside of health. The tweet data obtained was then carried out through content analysis, including point of view, theme, and sentiment analysis, to identify whether the resulting tweets are positive, neutral, or negative using the Support Vector Machine (SVM) method. We identified 1572 hyperlipidemia-related tweets and 153 specific tweets describing hyperlipidemia medications. Tweets about anti-hyperlipidemia showed 99 tweets from the first-person perspective, 23 from the second-person perspective, 22 from healthcare professionals, and nine unidentifiable (other). Sixty-three tweets talked about the benefits of lipid-lowering drugs, 17 complaint tweets, 49 suggestion tweets, 17 question tweets, and two side effect tweets. Assessing public perceptions and sentiment toward hyperlipidemia treatment can be used to develop strategies to increase treatment adherence, improve treatment outcomes, and target health promotion efforts.
{"title":"Public Perspective on Hyperlipidemia Drugs and Sentiments About Hyperlipidemia on Twitter","authors":"Murojil Hasan, Chairun Wiedyaningsih, Nanang Munif Yasin","doi":"10.33084/bjop.v6i3.4936","DOIUrl":"https://doi.org/10.33084/bjop.v6i3.4936","url":null,"abstract":"Hyperlipidemia is a non-communicable disease (NCD) caused by several factors, such as a person's socioeconomic status, culture, customs, habits, and lifestyle. Through user interaction on social media, we can discover the model anti-hyperlipidemia by extracting information, complaints, suggestions, and calls for help about the treatment, which will play a role as an intervention to reduce hyperlipidemia in Indonesia. This study aimed to identify factors influencing perceptions of hyperlipidemia drugs and resulting sentiment on the social media platform Twitter. This study used user-uploaded tweet data to compare perceptions of hyperlipidemia drugs in 2020 and keywords for hyperlipidemia terms and medicine. Tweets related to anti-hyperlipidemia were extracted by issuing tweets containing advertisements, news, re-tweet, and content outside of health. The tweet data obtained was then carried out through content analysis, including point of view, theme, and sentiment analysis, to identify whether the resulting tweets are positive, neutral, or negative using the Support Vector Machine (SVM) method. We identified 1572 hyperlipidemia-related tweets and 153 specific tweets describing hyperlipidemia medications. Tweets about anti-hyperlipidemia showed 99 tweets from the first-person perspective, 23 from the second-person perspective, 22 from healthcare professionals, and nine unidentifiable (other). Sixty-three tweets talked about the benefits of lipid-lowering drugs, 17 complaint tweets, 49 suggestion tweets, 17 question tweets, and two side effect tweets. Assessing public perceptions and sentiment toward hyperlipidemia treatment can be used to develop strategies to increase treatment adherence, improve treatment outcomes, and target health promotion efforts.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136242067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sri Mulyaningsih, Arya Guna Ramadhan, Widyasari Putranti
Acne vulgaris is a dermatological disease whose pathogenesis is due to high sebum secretion, hyperkeratinization, hormonal changes, or bacterial infections. Staphylococcus epidermidis and Staphylococcus aureus are bacteria that can induce inflammation in acne. Cinnamomum burmannii and Cymbopogon nardus essential oils have been reported to have antibacterial activity against S. epidermidis and S. aureus. This study aimed to obtain the type of interaction of a combination of C. burmannii and C. nardus oils in inhibiting bacteria associated with acne. Essential oil components were identified using gas chromatography-mass spectrometry (GCMS). Optimize the combination of C. burmannii and C. nardus oils using the checkerboard method. Furthermore, the Fractional Inhibitory Concentration Index (FICI) value is calculated to determine the effect of a combination that is synergistic, additive, not different or antagonistic. The main components of C. burmannii oil identified are cinnamaldehyde, eucalyptol, cinnamyl acetate, α-limonene, and α-terpineol. While C. nardus oil contains the five largest components: geraniol, citronellal, citronellol, citral, and geranyl acetate. Cinnamomum burmannii oil yielded 0.28%, with a refractive index of 1.5237. Meanwhile, the yield of C. nardus oil was 0.26%, with a refractive index of 1.4667. The combination of both oils yielded a FICI value of 1.5. The conclusion of this study shows that the combination of the two essential oils produces an indifferent effect against both S. epidermidis and S. aureus.
{"title":"Antibacterial Effect of Cinnamon and Citronella Oils Combination Against Acne-Related Bacteria","authors":"Sri Mulyaningsih, Arya Guna Ramadhan, Widyasari Putranti","doi":"10.33084/bjop.v6i3.4735","DOIUrl":"https://doi.org/10.33084/bjop.v6i3.4735","url":null,"abstract":"Acne vulgaris is a dermatological disease whose pathogenesis is due to high sebum secretion, hyperkeratinization, hormonal changes, or bacterial infections. Staphylococcus epidermidis and Staphylococcus aureus are bacteria that can induce inflammation in acne. Cinnamomum burmannii and Cymbopogon nardus essential oils have been reported to have antibacterial activity against S. epidermidis and S. aureus. This study aimed to obtain the type of interaction of a combination of C. burmannii and C. nardus oils in inhibiting bacteria associated with acne. Essential oil components were identified using gas chromatography-mass spectrometry (GCMS). Optimize the combination of C. burmannii and C. nardus oils using the checkerboard method. Furthermore, the Fractional Inhibitory Concentration Index (FICI) value is calculated to determine the effect of a combination that is synergistic, additive, not different or antagonistic. The main components of C. burmannii oil identified are cinnamaldehyde, eucalyptol, cinnamyl acetate, α-limonene, and α-terpineol. While C. nardus oil contains the five largest components: geraniol, citronellal, citronellol, citral, and geranyl acetate. Cinnamomum burmannii oil yielded 0.28%, with a refractive index of 1.5237. Meanwhile, the yield of C. nardus oil was 0.26%, with a refractive index of 1.4667. The combination of both oils yielded a FICI value of 1.5. The conclusion of this study shows that the combination of the two essential oils produces an indifferent effect against both S. epidermidis and S. aureus.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136242073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.57174/j.born.v3i2.102
W. Dharma, Cinthia Cristiana
Pengelolaan dan penyimpanan obat adalah aspek yang sangat penting, maka dari itu pengelolaan dan penyimpanan obat perlu dilaksanakan sebaik mungkin untuk mencegah terjadinya kerusakan pada obat. Penelitian ini bertujuan untuk mengevaluasi pengelolaan obat di Puskesmas Tampang Tumbang Anjir, Kecamatan Tampang Tumbang Anjir, Kabupaten Gunung Mas Kalimantan Tengah. Penelitian ini menggunakan metode observasional non eksperimental yang memiliki sifat deskriptif kuantitatif. Data pada penelitian ini diambil secara concurrent dari lembar resep, kartu stok, pelabelan dan waktu tunggu pelayanan resep. Penelitian ini memperoleh hasil persentase nilai barang rusak atau kedaluwarsa (18,09%), tingkat ketersediaan 1 bulan (1,3 bulan), jumlah item obat per resep (0,37%), kecepatan pelayanan resep non racikan memiliki rata-rata waktu (1,52 menit), kecepatan pelayanan resep racikan memiliki rata-rata waktu (1,01 menit), serta pada pelabelan obat memiliki persentase (0%). Sehingga didapatkan kesimpulan bahwa pengelolaan obat di Puskesmas Tampang Tumbang Anjir Kabupaten Gunung Mas Kalimantan Tengah belum memenuhi standar peraturan yang berlaku yakni Formularium Nasional (FORNAS) dan DOEN.
{"title":"Evaluasi Pengelolaan Obat dı Puskesmas Tampang Tumbang Anjir Kuala Kurun Kabupaten Gunung Mas Kalimantan Tengah Perıode Tahun 2022","authors":"W. Dharma, Cinthia Cristiana","doi":"10.57174/j.born.v3i2.102","DOIUrl":"https://doi.org/10.57174/j.born.v3i2.102","url":null,"abstract":"Pengelolaan dan penyimpanan obat adalah aspek yang sangat penting, maka dari itu pengelolaan dan penyimpanan obat perlu dilaksanakan sebaik mungkin untuk mencegah terjadinya kerusakan pada obat. Penelitian ini bertujuan untuk mengevaluasi pengelolaan obat di Puskesmas Tampang Tumbang Anjir, Kecamatan Tampang Tumbang Anjir, Kabupaten Gunung Mas Kalimantan Tengah. Penelitian ini menggunakan metode observasional non eksperimental yang memiliki sifat deskriptif kuantitatif. Data pada penelitian ini diambil secara concurrent dari lembar resep, kartu stok, pelabelan dan waktu tunggu pelayanan resep. Penelitian ini memperoleh hasil persentase nilai barang rusak atau kedaluwarsa (18,09%), tingkat ketersediaan 1 bulan (1,3 bulan), jumlah item obat per resep (0,37%), kecepatan pelayanan resep non racikan memiliki rata-rata waktu (1,52 menit), kecepatan pelayanan resep racikan memiliki rata-rata waktu (1,01 menit), serta pada pelabelan obat memiliki persentase (0%). Sehingga didapatkan kesimpulan bahwa pengelolaan obat di Puskesmas Tampang Tumbang Anjir Kabupaten Gunung Mas Kalimantan Tengah belum memenuhi standar peraturan yang berlaku yakni Formularium Nasional (FORNAS) dan DOEN.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90473431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Penyakit Jantung Koroner (PJK) terjadi ketika arteri koroner menyempit oleh penumpukan ateroma dan bahan berlemak di dalam dinding. Pemasangan stent dilakukan untuk mengobati arteri koroner yang menyempit dan menjadi pilihan jika penderita telah mencoba pengobatan atau perubahan gaya hidup tetapi tidak meningkatkan kesehatan jantung serta terdapat penyumbatan di arteri. Penelitian ini bertujuan mengevaluasi 4 ketepatan penggunaan obat, mengetahui karakteristik dan profil penggunaan obat pasien PJK pasca pemasangan stent di RSPAD Gatot Soebroto. Penelitian ini dilakukan secara deskriptif analitik dan pengambilan data secara retrospektif melalui rekam medik periode 2021. Sampel yang digunakan sebanyak 83 pasien. Hasil penelitian berdasarkan karakteristik bahwa pasien PJK pasca pemasangan stent terbanyak pada usia <65 tahun sebanyak 57 pasien (68,68%), komorbiditas terbanyak yaitu Hipertensi sebanyak 26 pasien (31,32%). Obat yang banyak digunakan pada pasien PJK pasca pemasangan stent yaitu kombinasi Aspirin dan Clopidogrel sebanyak 70 pasien (83,34%). Parameter ketepatan obat yang digunakan, yaitu tepat indikasi, tepat obat, tepat dosis, dan tepat pasien menunjukkan hasil 100% bahwa pasien mendapatkan kesesuaian penggunaan obat. Hasil hubungan variabel dengan penggunaan obat melalui SPSS, bahwa jenis kelamin memiliki nilai sig 0.051 (>0,05), usia memiliki nilai sig 0.544 (>0,05), dan faktor resiko memiliki nilai sig. 0.167 (>0,05) artinya tidak ada hubungan dalam penggunaan obat.
{"title":"Evaluası Penggunaan Obat Pasıen Penyakıt Jantung Koroner Pasca Pemasangan Stent dı RSPAD Gatot Soebroto","authors":"Alika Khansa Adita, W. Dharma","doi":"10.57174/j.born.v3i2.97","DOIUrl":"https://doi.org/10.57174/j.born.v3i2.97","url":null,"abstract":"Penyakit Jantung Koroner (PJK) terjadi ketika arteri koroner menyempit oleh penumpukan ateroma dan bahan berlemak di dalam dinding. Pemasangan stent dilakukan untuk mengobati arteri koroner yang menyempit dan menjadi pilihan jika penderita telah mencoba pengobatan atau perubahan gaya hidup tetapi tidak meningkatkan kesehatan jantung serta terdapat penyumbatan di arteri. Penelitian ini bertujuan mengevaluasi 4 ketepatan penggunaan obat, mengetahui karakteristik dan profil penggunaan obat pasien PJK pasca pemasangan stent di RSPAD Gatot Soebroto. Penelitian ini dilakukan secara deskriptif analitik dan pengambilan data secara retrospektif melalui rekam medik periode 2021. Sampel yang digunakan sebanyak 83 pasien. Hasil penelitian berdasarkan karakteristik bahwa pasien PJK pasca pemasangan stent terbanyak pada usia <65 tahun sebanyak 57 pasien (68,68%), komorbiditas terbanyak yaitu Hipertensi sebanyak 26 pasien (31,32%). Obat yang banyak digunakan pada pasien PJK pasca pemasangan stent yaitu kombinasi Aspirin dan Clopidogrel sebanyak 70 pasien (83,34%). Parameter ketepatan obat yang digunakan, yaitu tepat indikasi, tepat obat, tepat dosis, dan tepat pasien menunjukkan hasil 100% bahwa pasien mendapatkan kesesuaian penggunaan obat. Hasil hubungan variabel dengan penggunaan obat melalui SPSS, bahwa jenis kelamin memiliki nilai sig 0.051 (>0,05), usia memiliki nilai sig 0.544 (>0,05), dan faktor resiko memiliki nilai sig. 0.167 (>0,05) artinya tidak ada hubungan dalam penggunaan obat.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73497773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. I. Armadany, La Ode Muhammad Fitrawan, Fitri Rahmadani Saputri, Vica Aspadiah, Henny Kasmawati
Burns result from exposure to heat sources like fire, chemicals, or radiation and can lead to tissue loss or damage. Traditional healing of burns often involves using herbal remedies like gotu kola and coconut, typically oil extracts. This study aims to identify the healing effects of burns by administering a combination of ethyl acetate extract of gotu kola herb and virgin coconut oil (VCO) to mice. The mice were divided into 7 groups, namely negative control (K(-)) was given tween 20; positive control (K(+)): burn topical medicine on the market, P1: 10% Ethylacetate extract in tween 20; P2: VCO; P3: Ethyl acetate extract 10% and VCO 50% in tween 20; P4: 5% Ethyl acetate extract in VCO; P5: extract 10% Ethyl acetate in VCO and treated for 21 consecutive days with a frequency of twice a day. The results showed that the combination of 10% ethyl acetate extract of gotu kola herb in VCO exhibited the highest healing activity for burns, comparable to the positive control (K(+)) topical medicine on the market. The higher the extract concentration and VCO, the better the healing activity of burns.
{"title":"Combination of Gotu Kola (Centella asiatica (L.)) Ethyl Acetate Extract and Virgin Coconut Oil (VCO) as Burn Healing","authors":"F. I. Armadany, La Ode Muhammad Fitrawan, Fitri Rahmadani Saputri, Vica Aspadiah, Henny Kasmawati","doi":"10.57174/j.born.v3i2.89","DOIUrl":"https://doi.org/10.57174/j.born.v3i2.89","url":null,"abstract":"Burns result from exposure to heat sources like fire, chemicals, or radiation and can lead to tissue loss or damage. Traditional healing of burns often involves using herbal remedies like gotu kola and coconut, typically oil extracts. This study aims to identify the healing effects of burns by administering a combination of ethyl acetate extract of gotu kola herb and virgin coconut oil (VCO) to mice. The mice were divided into 7 groups, namely negative control (K(-)) was given tween 20; positive control (K(+)): burn topical medicine on the market, P1: 10% Ethylacetate extract in tween 20; P2: VCO; P3: Ethyl acetate extract 10% and VCO 50% in tween 20; P4: 5% Ethyl acetate extract in VCO; P5: extract 10% Ethyl acetate in VCO and treated for 21 consecutive days with a frequency of twice a day. The results showed that the combination of 10% ethyl acetate extract of gotu kola herb in VCO exhibited the highest healing activity for burns, comparable to the positive control (K(+)) topical medicine on the market. The higher the extract concentration and VCO, the better the healing activity of burns.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83665577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kayu bidara Laut (Strychnos ligustrina) telah dimanfaatkan secara turun-temurun oleh penduduk Nusa Tenggara Barat dan Bali sebagai obat tradisional untuk penyakit malaria. Tujuan penelitian ini adalah untuk mengidentifikasi kandungan senyawa kimia golongan alkaloid yang terkandung dalam ekstrak etanol kulit kayu bidara laut. Metode ekstraksi yang digunakan dalam penelitian ini adalah maserasi dengan menggunakan pelarut etanol 70%. Identifikasi kandungan alkaloid pada ekstrak kulit kayu bidara laut dilakukan dengan menggunakan instrumen LC-MS. Elusi gradien dilakukan selama 16 menit pada kolom fase balik dengan fase gerak yang digunakan adalah asam asetonitril dan asam format. Berdasarkan hasil analisis teridentifikasi lima senyawa alkaloid yaitu senyawa 3-iso-ajmalicine pada m/z 353.1847, dan waktu retensi 4.26 menit, senyawa brucine pada m/z 395.1953, dan waktu retensi 5.06 menit, serta molekul C24H28N2O4, C22H24N2O3, C11H17NO6 yang terkonfirmasi pada m/z masing – masing 409.2107, 365.1848, 260.1116, dan waktu retensi berturut – turut 4,90 menit, 5,35 menit, dan 1,32 menit. 3-iso-ajmalicine baru terkonfirmasi ada pada ekstrak kulit kayu bidara laut.
远洋莲木(Strychnos ligustrina)被西努萨人和巴厘岛人作为疟疾的传统药物传统使用。本研究的目的是确定含有在海洋莲花皮乙醇提取物中发现的生物碱化合物的含量。这项研究使用的提取方法是用70%的乙醇溶剂进行体外受精。在海中提取的皮中识别生物碱的成分使用了LC-MS仪器。梯形梯形在相位纵列中以16分钟的时间进行，并列使用的运动阶段是丙酮酸和酸性格式。根据分析的结果确认五生物碱化合物即3-iso-ajmalicine化合物在m - z 353。1847年,保留4 . 26分钟395 brucine化合物在m - z。1953年,保留5 . 6分钟C24H28N2O4分子、C22H24N2O3 C11H17NO6 m - z的确认对方——409 2107 365。1848年,260。是的,连续时间保留——有助于4,90 5.35分钟,1,32分钟。目前已确认为莲花皮质提取物。
{"title":"Identifikasi Senyawa Alkaloid dari Ekstrak Etanol Kulit Batang Strychnos ligustrina Menggunakan Liquid Chromatography-Mass Spectrometry (LC-MS)","authors":"S. Nurwanti, Andriningrum Sarnoko, A. Wulandari","doi":"10.57174/j.born.v3i2.82","DOIUrl":"https://doi.org/10.57174/j.born.v3i2.82","url":null,"abstract":"Kayu bidara Laut (Strychnos ligustrina) telah dimanfaatkan secara turun-temurun oleh penduduk Nusa Tenggara Barat dan Bali sebagai obat tradisional untuk penyakit malaria. Tujuan penelitian ini adalah untuk mengidentifikasi kandungan senyawa kimia golongan alkaloid yang terkandung dalam ekstrak etanol kulit kayu bidara laut. Metode ekstraksi yang digunakan dalam penelitian ini adalah maserasi dengan menggunakan pelarut etanol 70%. Identifikasi kandungan alkaloid pada ekstrak kulit kayu bidara laut dilakukan dengan menggunakan instrumen LC-MS. Elusi gradien dilakukan selama 16 menit pada kolom fase balik dengan fase gerak yang digunakan adalah asam asetonitril dan asam format. Berdasarkan hasil analisis teridentifikasi lima senyawa alkaloid yaitu senyawa 3-iso-ajmalicine pada m/z 353.1847, dan waktu retensi 4.26 menit, senyawa brucine pada m/z 395.1953, dan waktu retensi 5.06 menit, serta molekul C24H28N2O4, C22H24N2O3, C11H17NO6 yang terkonfirmasi pada m/z masing – masing 409.2107, 365.1848, 260.1116, dan waktu retensi berturut – turut 4,90 menit, 5,35 menit, dan 1,32 menit. 3-iso-ajmalicine baru terkonfirmasi ada pada ekstrak kulit kayu bidara laut.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91094722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bunga telang (Clitoria ternatea L.) memiliki efek antioksidan karena mengandung senyawa seperti fenol, antosianin, glikosida flavonol, glikosida kenferol, terpenoid, steroid, flavonoid, dan tanin. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol bunga telang memiliki aktivitas antioksidan, mengetahui apakah salep ekstrak etanol bunga telang dapat menyembuhkan luka sayat pada kelinci dan mengetahui konsentrasi efektif salep ekstrak etanol pada bunga telang untuk penyembuhan luka sayat pada kelinci. Penelitian ini menggunakan ekstrak bunga telang yang dimaserasi dengan etanol 70%. Konsentrasi ekstrak dibuat sebanyak 3 yaitu 0,1%, 0,2%, 0,4 %. Ekstrak diuji aktivitas antioksidan menggunakan metode DPPH. Ekstrak yang sudah diuji lalu dibuat salep dan diaplikasikan pada punggung kelinci, kemudian diamati kesembuhan luka. Berdasarkan hasil uji statistik menggunakan SPSS® variasi konsentrasi ekstrak etanol bunga telang berpengaruh terhadap aktivitas antioskidan. Konsentrasi 0,2% memberikan perbedaan yang signifikan dibandingkan dengan konsentrasi 0,1% dan 0,4%. Salep ekstrak etanol bunga telang dapat menyembuhkan luka sayat pada punggung kelinci. Berdasarkan hasil uji statistik menggunakan SPSS® terhadap penyembuhan luka sayat pada kelinci menunjukkan perbedaan yang signifikan. Konsentrasi 0,2% berbeda signifikan dengan konsentrasi 0,4% dimana waktu yang diperlukan konsentrasi 0,2% lebih cepat dibandingkan dengan konsentrasi 0,4%.
{"title":"Uji Antioksidan Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) dan Formulasi Salep pada Penyembuhan Luka Sayat Punggung Kelinci Putih New Zealand","authors":"Khusnul Hotimah, I. Iswandi, Jena Hayu Widyasti","doi":"10.57174/j.born.v3i2.85","DOIUrl":"https://doi.org/10.57174/j.born.v3i2.85","url":null,"abstract":"Bunga telang (Clitoria ternatea L.) memiliki efek antioksidan karena mengandung senyawa seperti fenol, antosianin, glikosida flavonol, glikosida kenferol, terpenoid, steroid, flavonoid, dan tanin. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol bunga telang memiliki aktivitas antioksidan, mengetahui apakah salep ekstrak etanol bunga telang dapat menyembuhkan luka sayat pada kelinci dan mengetahui konsentrasi efektif salep ekstrak etanol pada bunga telang untuk penyembuhan luka sayat pada kelinci. Penelitian ini menggunakan ekstrak bunga telang yang dimaserasi dengan etanol 70%. Konsentrasi ekstrak dibuat sebanyak 3 yaitu 0,1%, 0,2%, 0,4 %. Ekstrak diuji aktivitas antioksidan menggunakan metode DPPH. Ekstrak yang sudah diuji lalu dibuat salep dan diaplikasikan pada punggung kelinci, kemudian diamati kesembuhan luka. Berdasarkan hasil uji statistik menggunakan SPSS® variasi konsentrasi ekstrak etanol bunga telang berpengaruh terhadap aktivitas antioskidan. Konsentrasi 0,2% memberikan perbedaan yang signifikan dibandingkan dengan konsentrasi 0,1% dan 0,4%. Salep ekstrak etanol bunga telang dapat menyembuhkan luka sayat pada punggung kelinci. Berdasarkan hasil uji statistik menggunakan SPSS® terhadap penyembuhan luka sayat pada kelinci menunjukkan perbedaan yang signifikan. Konsentrasi 0,2% berbeda signifikan dengan konsentrasi 0,4% dimana waktu yang diperlukan konsentrasi 0,2% lebih cepat dibandingkan dengan konsentrasi 0,4%.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77530946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nyeri merupakan kondisi yang menandakan tubuh sedang mengalami kerusakan jaringan dan peradangan. Nyeri dapat diatasi dengan analgesik. Salah satu tanaman yang diduga mempunyai efek analgesik adalah daun matoa (Pometia pinnata J.R. Forst & G. Forst). Penelitian ini merupakan penelitian eksperimental menggunakan mencit putih jantan yang dibagi menjadi 5 kelompok perlakuan, yaitu kelompok I diberikan NaCMC sebagai kontrol negatif, kelompok II diberikan ibuprofen sebagai kontrol positif, serta kelompok III, IV, dan V diberikan EEDM dengan dosis berturut-turut 200 mg/kgBB, 400 mg/kgBB, dan 800 mg/kgBB. Hewan uji diinduksi dengan asam asetat 1% secara intraperitoneal setelah 30 menit pemberian sediaan uji secara oral. Pengamatan dilakukan dengan menghitung respon nyeri yang ditandai dengan geliat selama 180 menit dengan interval waktu 10 menit. Data penelitian diolah secara statistik menggunakan uji One Way ANOVA dan uji lanjutan LSD. Kelompok kontrol positif terhadap kelompok EEDM dosis 200 mg/kgBB, 400 mg/kgBB, dan 800 mg/kgBB menunjukkan hasil yang tidak berbeda nyata dengan nilai P>0,05. Dari hasil penelitian dapat di simpulkan bahwa EEDM memiiki efek sebagai analgesik pada mencit putih jantan dengan dosis efektif adalah 800 mg/kgBB.
{"title":"Uji Efek Analgesik Ekstrak Etanol Daun Matoa (Pometia pinnata J.R. Forst & G. Forst) pada Mencit Putih (Mus musculus) Jantan","authors":"Irma Santi, Bayu Putra, Fitka Ulfa Rahman","doi":"10.57174/j.born.v3i2.88","DOIUrl":"https://doi.org/10.57174/j.born.v3i2.88","url":null,"abstract":"Nyeri merupakan kondisi yang menandakan tubuh sedang mengalami kerusakan jaringan dan peradangan. Nyeri dapat diatasi dengan analgesik. Salah satu tanaman yang diduga mempunyai efek analgesik adalah daun matoa (Pometia pinnata J.R. Forst & G. Forst). Penelitian ini merupakan penelitian eksperimental menggunakan mencit putih jantan yang dibagi menjadi 5 kelompok perlakuan, yaitu kelompok I diberikan NaCMC sebagai kontrol negatif, kelompok II diberikan ibuprofen sebagai kontrol positif, serta kelompok III, IV, dan V diberikan EEDM dengan dosis berturut-turut 200 mg/kgBB, 400 mg/kgBB, dan 800 mg/kgBB. Hewan uji diinduksi dengan asam asetat 1% secara intraperitoneal setelah 30 menit pemberian sediaan uji secara oral. Pengamatan dilakukan dengan menghitung respon nyeri yang ditandai dengan geliat selama 180 menit dengan interval waktu 10 menit. Data penelitian diolah secara statistik menggunakan uji One Way ANOVA dan uji lanjutan LSD. Kelompok kontrol positif terhadap kelompok EEDM dosis 200 mg/kgBB, 400 mg/kgBB, dan 800 mg/kgBB menunjukkan hasil yang tidak berbeda nyata dengan nilai P>0,05. Dari hasil penelitian dapat di simpulkan bahwa EEDM memiiki efek sebagai analgesik pada mencit putih jantan dengan dosis efektif adalah 800 mg/kgBB.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88892037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inventory control is important in managerial activities because it involves investment and is hospitals' most significant expenditure component. The Aisyiyah Bojonegoro Hospital requires a logistics management system that can maintain the safety and effectiveness of the use of drugs for the smooth running of hospital pharmaceutical services in the long term. This analytical observational study analyzes management elements in controlling antibiotic inventory by simulating the Economic Order Quantity (EOQ) and Minimum-Maximum Stock Level (MMSL) methods. Determination of the sample purposively, i.e., 17 types of antibiotic drugs category A from the results of the ABC analysis, with the inclusion criteria being high cost, high volume, clinically important drugs for antibiotic drugs that are included in the 2020 Hospital Formulary and the exclusion criteria are drugs with inadequate supply. The analysis technique used the Mann-Whitney test and the Kruskal-Wallis test. Based on the results of the study, it was concluded that. Applying the EOQ and MMSL methods has been proven to increase the efficiency and effectiveness of the supply of category A antibiotics at Aisyiyah Bojonegoro Hospital.
{"title":"Analysis of Management Elements in Antibiotic Inventory Control with EOQ and MMSL Methods at Aisyiyah Bojonegoro Hospital","authors":"Pramono Apriawan Wijayanto, A. Sriatmi, S. Jati","doi":"10.33084/bjop.v6i2.3494","DOIUrl":"https://doi.org/10.33084/bjop.v6i2.3494","url":null,"abstract":"Inventory control is important in managerial activities because it involves investment and is hospitals' most significant expenditure component. The Aisyiyah Bojonegoro Hospital requires a logistics management system that can maintain the safety and effectiveness of the use of drugs for the smooth running of hospital pharmaceutical services in the long term. This analytical observational study analyzes management elements in controlling antibiotic inventory by simulating the Economic Order Quantity (EOQ) and Minimum-Maximum Stock Level (MMSL) methods. Determination of the sample purposively, i.e., 17 types of antibiotic drugs category A from the results of the ABC analysis, with the inclusion criteria being high cost, high volume, clinically important drugs for antibiotic drugs that are included in the 2020 Hospital Formulary and the exclusion criteria are drugs with inadequate supply. The analysis technique used the Mann-Whitney test and the Kruskal-Wallis test. Based on the results of the study, it was concluded that. Applying the EOQ and MMSL methods has been proven to increase the efficiency and effectiveness of the supply of category A antibiotics at Aisyiyah Bojonegoro Hospital.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82502396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stress can occur due to a person's inability to respond to a stressor, resulting in bodily or mental disorders. Anxiety can be characterized by increased levels of cortisol, which is regulated by the Hypothalamus-Pituitary-Adrenaline (HPA-axis). Aromatherapy is a therapy using essential oils that give a distinctive aroma to plant parts such as flowers, roots, leaves, and stems. Aromatherapy can be done through a reed diffuser. The frangipani (Plumeria alba) is one of the plants in Indonesia that has a particular scent in its flowers. This study aims to determine the effect of prolonged exposure to P. alba essential oil reed diffuser on cortisol levels in rats. Twenty-four rats were divided into four groups: the control group without exposure to a reed diffuser for 5 and 10 days and the other group with exposure for 5 and 10 days. Each blood was drawn through the retro-orbital, centrifuged to obtain serum, and tested using LC-MS to determine cortisol levels. The group with ten days of essential oil exposure showed lower cortisol levels. It can be concluded that the duration of aromatherapy exposure is connected to cortisol levels and that aromatherapy can be utilized as a stress-reduction therapy.
{"title":"The Effect of Long Exposure Reed Diffuser Essential Oil Plumeria alba on Cortisol Levels of Male Wistar Rats","authors":"S. Siska, T. Bariroh, S. Supandi","doi":"10.33084/bjop.v6i2.4387","DOIUrl":"https://doi.org/10.33084/bjop.v6i2.4387","url":null,"abstract":"Stress can occur due to a person's inability to respond to a stressor, resulting in bodily or mental disorders. Anxiety can be characterized by increased levels of cortisol, which is regulated by the Hypothalamus-Pituitary-Adrenaline (HPA-axis). Aromatherapy is a therapy using essential oils that give a distinctive aroma to plant parts such as flowers, roots, leaves, and stems. Aromatherapy can be done through a reed diffuser. The frangipani (Plumeria alba) is one of the plants in Indonesia that has a particular scent in its flowers. This study aims to determine the effect of prolonged exposure to P. alba essential oil reed diffuser on cortisol levels in rats. Twenty-four rats were divided into four groups: the control group without exposure to a reed diffuser for 5 and 10 days and the other group with exposure for 5 and 10 days. Each blood was drawn through the retro-orbital, centrifuged to obtain serum, and tested using LC-MS to determine cortisol levels. The group with ten days of essential oil exposure showed lower cortisol levels. It can be concluded that the duration of aromatherapy exposure is connected to cortisol levels and that aromatherapy can be utilized as a stress-reduction therapy.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74129161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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