N. M. D. Sandhiutami, S. Khairani, R. S. Dewi, Zainur Rahman Hakim, Anita Rahmi Pradani
Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inflammatory test, respectively, was 51.35%, 74.15%, and 74.01%. The results of the percentage inhibition of the analgesic test in mice for groups II, III, IV, and V were 55.25%, 38.52%, 44.53%, and 49.31%, and the percentage of effectiveness for the analgesic test, respectively, followed by 69.71%, 80.59%, and 89.24%. Based on the results, it can be concluded that the decoction of the MBP has an anti-inflammatory and analgesic effect.
{"title":"Anti-Inflammatory and Analgesic Activity of Musa balbisiana Peels In Vivo","authors":"N. M. D. Sandhiutami, S. Khairani, R. S. Dewi, Zainur Rahman Hakim, Anita Rahmi Pradani","doi":"10.33084/bjop.v5i2.3169","DOIUrl":"https://doi.org/10.33084/bjop.v5i2.3169","url":null,"abstract":"Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inflammatory test, respectively, was 51.35%, 74.15%, and 74.01%. The results of the percentage inhibition of the analgesic test in mice for groups II, III, IV, and V were 55.25%, 38.52%, 44.53%, and 49.31%, and the percentage of effectiveness for the analgesic test, respectively, followed by 69.71%, 80.59%, and 89.24%. Based on the results, it can be concluded that the decoction of the MBP has an anti-inflammatory and analgesic effect.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89396441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Lailaturrahmi, Fuji Araswati, A. Armenia, Rahmi Yosmar
Type 2 diabetes mellitus (T2DM) has been a health burden worldwide, including Indonesia. However, T2DM therapy needs a long and complex process, which patients often do not favor, thus making them does not take medications as instructed and negatively affecting clinical outcomes. This study aimed to understand the effect of Drug Information Service provision on the clinical outcome of T2DM patients. This quasi-experimental study was conducted using one group pre-post-test design. As the clinical outcome, the fasting blood glucose levels were measured before and after the intervention. A drug information service was provided through direct explanation to the patients. Sociodemographic data were analyzed descriptively. The difference in fasting blood glucose before and after the intervention was assessed using Wilcoxon signed-rank test. Forty patients participated in this study. Most participants are female (N=34; 85%) and receive two-drugs combination therapy of metformin and sulfonylureas (N=32; 77.5%). Although there is a decrease in mean fasting blood glucose level after intervention (174.92±59.561 vs. 184.20±49.768), there is no significant difference between fasting blood glucose levels pre-intervention and post-intervention (p>0.05). It is concluded that despite the noticeable decline of blood glucose level after drug information service, its effect on blood glucose control is not significant.
2型糖尿病(T2DM)一直是世界范围内的健康负担，包括印度尼西亚。然而，T2DM治疗需要一个漫长而复杂的过程，患者往往不赞成，从而使他们不按指示服药，对临床结果产生负面影响。本研究旨在了解药物信息服务对2型糖尿病患者临床转归的影响。本准实验研究采用一组前-后测试设计。作为临床结果，测量干预前后的空腹血糖水平。通过对患者的直接讲解，为患者提供药品信息服务。对社会人口统计数据进行描述性分析。采用Wilcoxon sign -rank检验评估干预前后空腹血糖的差异。40名患者参与了这项研究。大多数参与者为女性(N=34;85%)，并接受二甲双胍和磺脲类双药联合治疗(N=32;77.5%)。虽然干预后空腹血糖水平有所下降(174.92±59.561 vs 184.20±49.768)，但干预前与干预后空腹血糖水平无显著差异(p < 0.05)。综上所述，药物信息服务后患者血糖水平虽有明显下降，但对血糖控制的作用并不显著。
{"title":"Effect of Drug Information Service on Clinical Outcome of Patients with Type 2 Diabetes Mellitus in Padang, Indonesia","authors":"L. Lailaturrahmi, Fuji Araswati, A. Armenia, Rahmi Yosmar","doi":"10.33084/bjop.v5i2.3301","DOIUrl":"https://doi.org/10.33084/bjop.v5i2.3301","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) has been a health burden worldwide, including Indonesia. However, T2DM therapy needs a long and complex process, which patients often do not favor, thus making them does not take medications as instructed and negatively affecting clinical outcomes. This study aimed to understand the effect of Drug Information Service provision on the clinical outcome of T2DM patients. This quasi-experimental study was conducted using one group pre-post-test design. As the clinical outcome, the fasting blood glucose levels were measured before and after the intervention. A drug information service was provided through direct explanation to the patients. Sociodemographic data were analyzed descriptively. The difference in fasting blood glucose before and after the intervention was assessed using Wilcoxon signed-rank test. Forty patients participated in this study. Most participants are female (N=34; 85%) and receive two-drugs combination therapy of metformin and sulfonylureas (N=32; 77.5%). Although there is a decrease in mean fasting blood glucose level after intervention (174.92±59.561 vs. 184.20±49.768), there is no significant difference between fasting blood glucose levels pre-intervention and post-intervention (p>0.05). It is concluded that despite the noticeable decline of blood glucose level after drug information service, its effect on blood glucose control is not significant.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77269462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Quercetin is a flavonoid from a group of polyphenolic flavonoid compounds. Quercetin can be used as an alternative to acne treatment, predominantly triggered by Propionibacterium acnes. This study aimed to determine the effect and proportion of carbopol 940, propylene glycol, and glycerin on the physical quality of quercetin gel, the ability of the optimum formula in an antibacterial test, and its diffusion using Franz diffusion. This study uses the factorial design method for formula optimization. Optimization was carried out with the parameters of the physical quality of the gel tested, including viscosity, dispersibility, antibacterial, and Franz diffusion. The combination of carbopol 940, glycerin, and propylene glycol affected the physical quality test of quercetin gel, carbopol and glycerin significantly affected viscosity. In contrast, glycerin and propylene glycol significantly affected Franz's dispersion, antibacterial, and diffusion properties. The optimum proportion of the combination of carbopol 940, glycerin, and propylene glycol in the manufacture of quercetin gel using the factorial design method obtained a concentration of carbopol 940 of 0.5%, glycerin of 15%, and propylene glycol of 10%. The optimum formula ability in the antibacterial test was 22.20 mm, and the cumulative percent of quercetin penetrated was 97.91%.
{"title":"Optimization of Quercetin Gel Formulation using Factorial Design Method and Antibacterial Test against Propionibacterium acnes","authors":"M. Chandra, I. Kuncahyo, A. Indrayati","doi":"10.33084/bjop.v5i2.3321","DOIUrl":"https://doi.org/10.33084/bjop.v5i2.3321","url":null,"abstract":"Quercetin is a flavonoid from a group of polyphenolic flavonoid compounds. Quercetin can be used as an alternative to acne treatment, predominantly triggered by Propionibacterium acnes. This study aimed to determine the effect and proportion of carbopol 940, propylene glycol, and glycerin on the physical quality of quercetin gel, the ability of the optimum formula in an antibacterial test, and its diffusion using Franz diffusion. This study uses the factorial design method for formula optimization. Optimization was carried out with the parameters of the physical quality of the gel tested, including viscosity, dispersibility, antibacterial, and Franz diffusion. The combination of carbopol 940, glycerin, and propylene glycol affected the physical quality test of quercetin gel, carbopol and glycerin significantly affected viscosity. In contrast, glycerin and propylene glycol significantly affected Franz's dispersion, antibacterial, and diffusion properties. The optimum proportion of the combination of carbopol 940, glycerin, and propylene glycol in the manufacture of quercetin gel using the factorial design method obtained a concentration of carbopol 940 of 0.5%, glycerin of 15%, and propylene glycol of 10%. The optimum formula ability in the antibacterial test was 22.20 mm, and the cumulative percent of quercetin penetrated was 97.91%.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79241289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Covid-19 has spread globally and causes severe acute respiratory syndrome. The symptoms of covid-19 have similarities with influenza, such as cough, fever, runny nose, and sore throat. Therefore, the internet sources tend to have an increasing search related to influenza symptoms drugs. This study aims to assess the search trend of influenza symptoms drugs using google trend analysis in Indonesia. We explore google trend analysis using search terms in the Indonesian language related to influenza symptoms drugs from December 6th, 2020 to November 30th, 2021. The positive confirmed cases were obtained from the Indonesian government website https://covid19.go.id/. Our results demonstrated the increasing search terms related to influenza drug symptoms during July and August. The highest term search was “obat batuk”. The positive covid-19 confirmed cases in Indonesia increased during July and August. During the peak of the covid-19 outbreak in Indonesia in July-August 2021, there was an increase in google trends searching related to influenza’s drug symptoms.
{"title":"Trends of Influenza’s Symptoms Drug Search Terms in Indonesian-Language using Google Trends in the Covid-19 Pandemic","authors":"N. Syifa, Nurul Purborini","doi":"10.33084/bjop.v5i2.2997","DOIUrl":"https://doi.org/10.33084/bjop.v5i2.2997","url":null,"abstract":"Covid-19 has spread globally and causes severe acute respiratory syndrome. The symptoms of covid-19 have similarities with influenza, such as cough, fever, runny nose, and sore throat. Therefore, the internet sources tend to have an increasing search related to influenza symptoms drugs. This study aims to assess the search trend of influenza symptoms drugs using google trend analysis in Indonesia. We explore google trend analysis using search terms in the Indonesian language related to influenza symptoms drugs from December 6th, 2020 to November 30th, 2021. The positive confirmed cases were obtained from the Indonesian government website https://covid19.go.id/. Our results demonstrated the increasing search terms related to influenza drug symptoms during July and August. The highest term search was “obat batuk”. The positive covid-19 confirmed cases in Indonesia increased during July and August. During the peak of the covid-19 outbreak in Indonesia in July-August 2021, there was an increase in google trends searching related to influenza’s drug symptoms.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72943973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Assalamu’alaikum Wr. Wb. Alhamdulillahirabbil ‘alamin. The next edition of the Borneo Journal of Pharmacy (Borneo J Pharm) has been published in May 2022. This edition contains ten articles consisting of Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Microbiology Pharmacy, Natural Product Development, and Clinical-Community Pharmacy. This edition includes writings from four countries, including India, Indonesia, Nigeria, and Sri Lanka. The authors come from several institutions, including Universitas Pancasila, University of Jaffna, Universitas Muhammadiyah Prof. Dr. HAMKA, Universitas Setia Budi, Federal University Birnin Kebbi, Kano State Polytechnic, Universitas Muhammadiyah Palangkaraya, Prathima Institute of Medical Sciences, Bhaskar Pharmacy College, Ganapathy Degree College, Universitas Muhammadiyah Malang, Universitas Muhammadiyah Magelang, and Universitas Andalas. Editorial boards are fully aware that there is still room for improvement in this edition, hence with all humility, willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors, could re-participate for publication in the next edition in August 2022. Wassalamu’alaikum Wr. Wb.
{"title":"Cover, Content, and Editorial Note from Borneo J Pharm Vol. 5 No. 2 May 2022","authors":"C. E. O. Borneo J Pharm","doi":"10.33084/bjop.v5i2.3762","DOIUrl":"https://doi.org/10.33084/bjop.v5i2.3762","url":null,"abstract":"Assalamu’alaikum Wr. Wb. \u0000Alhamdulillahirabbil ‘alamin. The next edition of the Borneo Journal of Pharmacy (Borneo J Pharm) has been published in May 2022. This edition contains ten articles consisting of Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Microbiology Pharmacy, Natural Product Development, and Clinical-Community Pharmacy. This edition includes writings from four countries, including India, Indonesia, Nigeria, and Sri Lanka. The authors come from several institutions, including Universitas Pancasila, University of Jaffna, Universitas Muhammadiyah Prof. Dr. HAMKA, Universitas Setia Budi, Federal University Birnin Kebbi, Kano State Polytechnic, Universitas Muhammadiyah Palangkaraya, Prathima Institute of Medical Sciences, Bhaskar Pharmacy College, Ganapathy Degree College, Universitas Muhammadiyah Malang, Universitas Muhammadiyah Magelang, and Universitas Andalas. \u0000Editorial boards are fully aware that there is still room for improvement in this edition, hence with all humility, willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors, could re-participate for publication in the next edition in August 2022. \u0000Wassalamu’alaikum Wr. Wb.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79854542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Susi Novaryatiin, Nursheilla Rizky Amalia, S. Ardhany
Bawang dayak (Eleutherine bulbosa (Mill.) Urb is one of the notable Iridaceae family, originating from Central Kalimantan, Indonesia. Previous studies have reported that E. bulbosa ethanol extract and its cream preparation have antibacterial properties that can inhibit the growth of acne-causing bacteria and cause no significant skin adverse reaction. This study aimed to make a loose powder preparation from E. bulbosa ethanol extract and determine its physical evaluation and antibacterial activity. Loose powder formulation was made with various concentrations of E. bulbosa ethanol extract, F0 (0%), F1 (5%), F2 (10%), and F3 (15%). Loose powder evaluates for organoleptic, homogeneity, and antibacterial activity by the disc diffusion method. The results show that E. bulbosa ethanol extract can produce a loose powder formulation. The color of the formula is rather yellow (F0), brown-ash (F1), and light brown (F2 and F3), which has a typical mint odor, smooth texture, and homogeneous. All formulations inhibited the growth of Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus. This present study showed the potential of Formula 3 (F3) as an anti-acne loose powder due to its organoleptic properties, homogeneity, and antibacterial activity, which has the largest inhibition zone diameter of 17.6 ± 3.1 mm.
{"title":"Formulation of Anti Acne Loose Powder of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Ethanol Extract","authors":"Susi Novaryatiin, Nursheilla Rizky Amalia, S. Ardhany","doi":"10.33084/bjop.v5i2.3153","DOIUrl":"https://doi.org/10.33084/bjop.v5i2.3153","url":null,"abstract":"Bawang dayak (Eleutherine bulbosa (Mill.) Urb is one of the notable Iridaceae family, originating from Central Kalimantan, Indonesia. Previous studies have reported that E. bulbosa ethanol extract and its cream preparation have antibacterial properties that can inhibit the growth of acne-causing bacteria and cause no significant skin adverse reaction. This study aimed to make a loose powder preparation from E. bulbosa ethanol extract and determine its physical evaluation and antibacterial activity. Loose powder formulation was made with various concentrations of E. bulbosa ethanol extract, F0 (0%), F1 (5%), F2 (10%), and F3 (15%). Loose powder evaluates for organoleptic, homogeneity, and antibacterial activity by the disc diffusion method. The results show that E. bulbosa ethanol extract can produce a loose powder formulation. The color of the formula is rather yellow (F0), brown-ash (F1), and light brown (F2 and F3), which has a typical mint odor, smooth texture, and homogeneous. All formulations inhibited the growth of Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus. This present study showed the potential of Formula 3 (F3) as an anti-acne loose powder due to its organoleptic properties, homogeneity, and antibacterial activity, which has the largest inhibition zone diameter of 17.6 ± 3.1 mm.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81466705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Campylobacter species continue to remain critical pathogens of public health interest. They are responsible for approximately 500 million cases of gastroenteritis per year worldwide. Infection occurs through the consumption of contaminated food and water. Microbial risk assessment and source tracking are crucial epidemiological strategies to monitor the outbreak of campylobacteriosis effectively. Various methods have been proposed for microbial source tracking and risk assessment, most of which rely on conventional microbiological techniques such as detecting fecal indicator organisms and other novel microbial source tracking methods, including library-dependent microbial source tracking and library-independent source tracking approaches. However, both the traditional and novel methods have their setbacks. For example, while the conventional techniques are associated with a poor correlation between indicator organism and pathogen presence, on the other hand, it is impractical to interpret qPCR-generated markers to establish the exact human health risks even though it can give information regarding the potential source and relative human risk. Therefore, this article provides up-to-date information on campylobacteriosis, various approaches for source attribution, and risk assessment of bacterial pathogens, including next-generation sequencing approaches such as shotgun metagenomics, which effectively answer the questions of potential pathogens are there and in what quantities.
{"title":"Campylobacter Species, Microbiological Source Tracking and Risk Assessment of Bacterial pathogens","authors":"B. Gulumbe, A. Bazata, M. A. Bagwai","doi":"10.33084/bjop.v5i2.3363","DOIUrl":"https://doi.org/10.33084/bjop.v5i2.3363","url":null,"abstract":"Campylobacter species continue to remain critical pathogens of public health interest. They are responsible for approximately 500 million cases of gastroenteritis per year worldwide. Infection occurs through the consumption of contaminated food and water. Microbial risk assessment and source tracking are crucial epidemiological strategies to monitor the outbreak of campylobacteriosis effectively. Various methods have been proposed for microbial source tracking and risk assessment, most of which rely on conventional microbiological techniques such as detecting fecal indicator organisms and other novel microbial source tracking methods, including library-dependent microbial source tracking and library-independent source tracking approaches. However, both the traditional and novel methods have their setbacks. For example, while the conventional techniques are associated with a poor correlation between indicator organism and pathogen presence, on the other hand, it is impractical to interpret qPCR-generated markers to establish the exact human health risks even though it can give information regarding the potential source and relative human risk. Therefore, this article provides up-to-date information on campylobacteriosis, various approaches for source attribution, and risk assessment of bacterial pathogens, including next-generation sequencing approaches such as shotgun metagenomics, which effectively answer the questions of potential pathogens are there and in what quantities.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76163315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the era of emerging microbial and non-communicable diseases and re-emerging microbial infections, the medical fraternity and the public are plagued by under-preparedness. It is evident by the severity of the Coronavirus disease (COVID-19) pandemic that novel microbial diseases are a challenge and are challenging to control. This is mainly attributed to the lack of complete knowledge of the novel microbe’s biology and pathogenesis and the unavailability of therapeutic drugs and vaccines to treat and control the disease. Clinical research is the only answer utilizing which can handle most of these circumstances. In this review, we highlight the importance of computer-assisted drug designing (CADD) and the aspects of molecular docking, molecular superimposition, 3D-pharmacophore technology, ethics, and good clinical practice (GCP) for the development of therapeutic drugs, devices, and vaccines.
{"title":"The Current Perspectives in Clinical Research: Computer-Assisted Drug Designing, Ethics, and Good Clinical Practice","authors":"V. Kandi, Anusha Vundecode, Tanmai Reddy Godalwar, Sindhusree Dasari, Sabitha Vadakedath, Vikram Godishala","doi":"10.33084/bjop.v5i2.3013","DOIUrl":"https://doi.org/10.33084/bjop.v5i2.3013","url":null,"abstract":"In the era of emerging microbial and non-communicable diseases and re-emerging microbial infections, the medical fraternity and the public are plagued by under-preparedness. It is evident by the severity of the Coronavirus disease (COVID-19) pandemic that novel microbial diseases are a challenge and are challenging to control. This is mainly attributed to the lack of complete knowledge of the novel microbe’s biology and pathogenesis and the unavailability of therapeutic drugs and vaccines to treat and control the disease. Clinical research is the only answer utilizing which can handle most of these circumstances. In this review, we highlight the importance of computer-assisted drug designing (CADD) and the aspects of molecular docking, molecular superimposition, 3D-pharmacophore technology, ethics, and good clinical practice (GCP) for the development of therapeutic drugs, devices, and vaccines.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82623940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Metadon merupakan jenis narkotika sintetik yang digunakan sebagai terapi substitusi pada Program Terapi Rumatan Metadon (PTRM). Oleh sebab itu, metadon harus diperlakukan sebagaimana narkotika pada umumnya. Tenaga kefarmasian dalam PTRM mempunyai tanggung jawab terhadap pengelolaan metadon. Penelitian ini bertujuan untuk mengevaluasi kesesuaian pengelolaan sediaan metadon di satelit pelayanan PTRM di provinsi Daerah Istimewa Yogyakarta (DIY) berdasarkan pedoman PTRM yang dikeluarkan oleh kemenkes yang meliputi permintaan, penyimpanan, dispensing, dan pelaporan penggunaan metadon. Penelitian ini merupakan penelitian mixed-methods (kualitatif dan kuantitatif) dengan pengambilan data secara prospektif. Instrumen pengukuran kuantitatif dalam penelitian berupa tabel checklist keseuaian pengelolaan metadon berdasarkan pedoman yang berlaku. Data kualitatif bersumber dari hasil wawancara dengan petugas PTRM. Hasil penelitian ini menunjukan bahwa permintaan, penyimpanan, dan pelaporan penggunaan metadon sudah sesuai dengan pedoman pelayanan PTRM. Namun untuk dispensing metadon di satelit pelayanan PTRM masih ada yang dilakukan oleh selain tenaga kefarmasian.
{"title":"Pengelolaan sedıaan metadon pada Program Terapı Rumatan Metadon (PTRM) dı satelıt pelayanan PTRM","authors":"Julaeha Julaeha, Nunung Priyatni, R. Rustamaji","doi":"10.57174/jborn.v2i1.17","DOIUrl":"https://doi.org/10.57174/jborn.v2i1.17","url":null,"abstract":"Metadon merupakan jenis narkotika sintetik yang digunakan sebagai terapi substitusi pada Program Terapi Rumatan Metadon (PTRM). Oleh sebab itu, metadon harus diperlakukan sebagaimana narkotika pada umumnya. Tenaga kefarmasian dalam PTRM mempunyai tanggung jawab terhadap pengelolaan metadon. Penelitian ini bertujuan untuk mengevaluasi kesesuaian pengelolaan sediaan metadon di satelit pelayanan PTRM di provinsi Daerah Istimewa Yogyakarta (DIY) berdasarkan pedoman PTRM yang dikeluarkan oleh kemenkes yang meliputi permintaan, penyimpanan, dispensing, dan pelaporan penggunaan metadon. Penelitian ini merupakan penelitian mixed-methods (kualitatif dan kuantitatif) dengan pengambilan data secara prospektif. Instrumen pengukuran kuantitatif dalam penelitian berupa tabel checklist keseuaian pengelolaan metadon berdasarkan pedoman yang berlaku. Data kualitatif bersumber dari hasil wawancara dengan petugas PTRM. Hasil penelitian ini menunjukan bahwa permintaan, penyimpanan, dan pelaporan penggunaan metadon sudah sesuai dengan pedoman pelayanan PTRM. Namun untuk dispensing metadon di satelit pelayanan PTRM masih ada yang dilakukan oleh selain tenaga kefarmasian.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73077586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Penyakit jantung koroner merupakan salah satu penyakit penyebab kematian terbanyak. ST-segment elevation myocardial infarction (STEMI) salah satu klasifikasi dari Infark Miokard Akut (IMA). IMA timbul dari kerusakan permanen pada otot jantung karena suplai oksigen yang tidak mencukupi. Adanya IMA dapat merusak fungsi sistol dan diastol, serta menambah kejadian yang tidak diharapkan seperti aritmia pada pasien. Tujuan dari penelitian ini adalah melihat penggunaan antikoagulan pada pasien STEMI yang menggunakan terapi fibrinolitik. Penelitian ini bersifat deskriptif yang dilakukan secara retrospektif dengan melihat catatan medis pasien STEMI yang menjalani rawat inap di RS “X” kota Tarakan periode 2017-2018. Hasil penelitian menunjukan bahwa semua pasien STEMI menerima terapi antikoagulan. Sebanyak 92,31 % menggunakan enoxaparin dan 7,69 % pasien menggunaan fondaparinux dengan karakteristik pasien sebanyak 12 penyakit penyerta. Pemberian antikoagulan pada pasien STEMI membantu menjaga kondisi arteri setelah proses reperfusi ketika telah diberikan fibrinolitik sehingga tidak menyebabkan terjadinya reoklusi.
{"title":"Gambaran penggunaan antikoagulan pada pasien ST-Elevatıon Myocardıal Infarctıon (STEMI)","authors":"Rizqa Aulia Rahmah, Irma Novrianti, Syuhada Syuhada","doi":"10.57174/jborn.v2i1.15","DOIUrl":"https://doi.org/10.57174/jborn.v2i1.15","url":null,"abstract":"Penyakit jantung koroner merupakan salah satu penyakit penyebab kematian terbanyak. ST-segment elevation myocardial infarction (STEMI) salah satu klasifikasi dari Infark Miokard Akut (IMA). IMA timbul dari kerusakan permanen pada otot jantung karena suplai oksigen yang tidak mencukupi. Adanya IMA dapat merusak fungsi sistol dan diastol, serta menambah kejadian yang tidak diharapkan seperti aritmia pada pasien. Tujuan dari penelitian ini adalah melihat penggunaan antikoagulan pada pasien STEMI yang menggunakan terapi fibrinolitik. Penelitian ini bersifat deskriptif yang dilakukan secara retrospektif dengan melihat catatan medis pasien STEMI yang menjalani rawat inap di RS “X” kota Tarakan periode 2017-2018. Hasil penelitian menunjukan bahwa semua pasien STEMI menerima terapi antikoagulan. Sebanyak 92,31 % menggunakan enoxaparin dan 7,69 % pasien menggunaan fondaparinux dengan karakteristik pasien sebanyak 12 penyakit penyerta. Pemberian antikoagulan pada pasien STEMI membantu menjaga kondisi arteri setelah proses reperfusi ketika telah diberikan fibrinolitik sehingga tidak menyebabkan terjadinya reoklusi.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73164609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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