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Analysis of the efficacy of different amounts of parathyroid grafts in the treatment of secondary hyperparathyroidism. 分析不同数量的甲状旁腺移植物在治疗继发性甲状旁腺功能亢进症中的疗效。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-12 DOI: 10.1186/s12902-024-01777-0
Wentan Chen, Ge Zhou

Purpose: This study compares the efficacy of two different ranges of parathyroid transplantation weights with the aim of determining a preferable range for transplantation weight.

Methods: From May 2018 to June 2023, 79 patients underwent total parathyroidectomy with autotransplantation. Demographic data, symptoms, and pre- or postoperative biochemical indicators were compared between two different ranges of parathyroid transplantation weights.

Results: All 79 surgeries were successful, with a total of 316 parathyroid glands reported among the patients. The patients were diagnosed with parathyroid hyperplasia. Postoperatively, itching, bone pain, and muscle weakness disappeared, while serum parathyroid hormone and phosphate levels significantly decreased. With an average follow-up of 12 months, no transplant-dependent recurrence was observed.

Conclusion: Parathyroid transplantation with a weight of 30-50 mg is a feasible, safe, and effective surgical approach.

目的:本研究比较了两种不同范围的甲状旁腺移植重量的疗效,旨在确定移植重量的优选范围:2018年5月至2023年6月,79名患者接受了甲状旁腺全切除术并进行了自体移植。比较了两种不同范围的甲状旁腺移植重量的人口统计学数据、症状和术前或术后生化指标:79例手术全部成功,患者共报告了316个甲状旁腺。患者被诊断为甲状旁腺增生症。术后,瘙痒、骨痛和肌肉无力症状消失,血清甲状旁腺激素和磷酸盐水平显著下降。平均随访12个月,未发现移植依赖性复发:结论:重量为30-50毫克的甲状旁腺移植是一种可行、安全且有效的手术方法。
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引用次数: 0
Association of time in range with cognitive impairment in middle-aged type 2 diabetic patients. 中年 2 型糖尿病患者的认知障碍与在量程范围内的时间有关。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-08 DOI: 10.1186/s12902-024-01772-5
Yanting Liu, Yanlan Liu, Huina Qiu, Nahal Haghbin, Jingbo Li, Yaoshuang Li, Weiran Jiang, Longfei Xia, Fan Wu, Chenying Lin, Jingna Lin, Chunjun Li

Objective: This study investigated the association of Time In Range (TIR) obtained from Blood Glucose Monitoring (BGM) with Cognitive Impairment (CI) inpatients with middle-aged Type 2 Diabetes Mellitus (T2DM) and further explored whether a TIR goal for T2DM in adults with > 70% possess a protective effect on cognitive function.

Research design and methods: A total of 274 inpatients with T2DM aged 40-64 years, who underwent seven-point BGM ( pre meals and 120 min post meals and at bedtime) were recruited in this cross-sectional study. TIR was defined as the percentage of blood glucose within the target range of 3.9-10.0mmol/L. Subjects were divided into Normal Cognitive Function (NCF) (n = 160) and CI (n = 114) groups according to the results of the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). The association of TIR and other glycemic metrics, calculated from seven-point BGM data, with cognitive dysfunction was analyzed.

Results: The prevalence of CI was 41.6% in patients with middle-aged T2DM (median age 58 years). TIR was lower in CI group than in NCF group (28.6% vs. 42.9%, P = 0.004). The prevalence of CI decreased with ascending tertiles of TIR (p for trend < 0.05). Binary logistic regression analysis showed a significant association between TIR and CI (odds ratio [OR] = 0.84, p < 0.001) after adjusting for confounders (age, education, marital status, age at Diabetes Mellitus (DM) onset, cerebrovascular disease). Further adjustment of Standard Deviation (SD)(OR = 0.84, p = 0.001) or Coefficient of Variation (CV)(OR = 0.83, p < 0.001), TIR was still associated with CI. While a TIR goal of > 70% probably possessed independent protective effect on cognitive function (OR = 0.25, p = 0.001) after controlling for confounders above.

Conclusions: TIR obtained from BGM was related to CI in middle-aged T2DM individuals and a TIR goal of > 70% probably possessed a protective effect on cognitive function for middle-aged T2DM .

研究目的本研究调查了中年2型糖尿病(T2DM)患者通过血糖监测(BGM)获得的 "在量程内时间"(TIR)与认知功能障碍(CI)之间的关系,并进一步探讨了TIR>70%的T2DM患者是否对认知功能具有保护作用:这项横断面研究共招募了274名年龄在40-64岁之间的T2DM住院患者,他们均接受了七点血糖监测(餐前、餐后120分钟和睡前)。TIR定义为血糖在3.9-10.0mmol/L目标范围内的百分比。根据蒙特利尔认知评估(MoCA)和迷你精神状态检查(MMSE)的结果,受试者被分为认知功能正常组(NCF,n = 160)和认知功能障碍组(CI,n = 114)。根据七点血糖监测数据计算出的 TIR 和其他血糖指标与认知功能障碍的关联进行了分析:在中年 T2DM 患者(中位年龄 58 岁)中,CI 患病率为 41.6%。CI 组的 TIR 低于 NCF 组(28.6% 对 42.9%,P = 0.004)。在控制了上述混杂因素后,CI 的患病率随 TIR 值的递增而降低(P 为趋势的 70%),可能对认知功能具有独立的保护作用(OR = 0.25,P = 0.001):中年 T2DM 患者从血糖仪获得的 TIR 与 CI 有关,TIR > 70% 的目标可能对中年 T2DM 患者的认知功能具有保护作用。
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引用次数: 0
Relationship of serum iron and thyroid hormone in obesity and after laparoscopic sleeve gastrectomy. 肥胖症和腹腔镜袖带胃切除术后血清铁和甲状腺激素的关系。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-07 DOI: 10.1186/s12902-024-01753-8
Xingchun Wang, Yaling Fang, Xiu Huang, Lei Du, Hui Ren, Chunjun Sheng, Peng Yang, Yueye Huang, Shen Qu

Background: Iron is an essential element for thyroid function. However, no study focuses on the association between iron and thyroid in individuals with obesity. Our research aimed to investigate the iron status in relation to baseline thyroid hormone levels and after laparoscopic sleeve gastrectomy (LSG).

Methods: A total of 216 subjects with obesity were enrolled and divided into low and high iron groups depending on the median value. The association between iron and thyroid hormone was analyzed and compared before and after LSG at the 6-month follow-up in patients who underwent LSG.

Results: 1) In all, Total Triiodothyronine (TT3) was significantly higher in high iron than low iron group (P = 0.008). TT3 and thyroid stimulating hormone (TSH) were significantly higher in high iron than low iron group (1.92 ± 0.61 vs. 1.69 ± 0.28 nmol/l, P = 0.029; 2.93 ± 1.66 vs. 1.88 ± 1.03 mU/l, P = 0.002) in females while not in males (all P > 0.05). 2) Iron was significantly positively associated with free triiodothyronine (FT3), free thyroxine (FT4), TT3 and TSH (all P < 0.05). Adjusted for body mass index (BMI), total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), fasting insulin (FINS) and homeostatic model assessment of insulin resistance (HOMA-IR), FT3, FT4 and TSH were still significantly associated with iron (all P < 0.05). 3). Regression analysis showed that iron was significantly associated with FT4 (β = 0.338, P = 0.038). 3) LSG led to decreased FT3, FT3, TT3, total thyroxine (TT4) and TSH at 6 months follow-up (all P < 0.05). Changed FT4 was significantly associated with changed iron (r = 0.520, P = 0.009). Subjects with iron decreased had more significant decreased TT4 than subjects without iron decreased (P = 0.021).

Conclusion: Serum iron overload is significantly associated with impaired thyroid function in subjects with obesity. LSG led to improved thyroid function which is associated with a change in iron.

Trial registration: NCT04548232 registration date is on October 9, 2022, registered in https://register.

Clinicaltrials: gov/ .

背景:铁是甲状腺功能所必需的元素。然而,还没有研究关注肥胖症患者体内铁与甲状腺之间的关系。我们的研究旨在调查铁的状态与基线甲状腺激素水平以及腹腔镜袖带胃切除术(LSG)后的关系:方法:我们共招募了 216 名肥胖症患者,并根据中位值将其分为低铁组和高铁组。方法:共招募了 216 名肥胖症患者,根据中位值将其分为低铁组和高铁组,并在 6 个月的随访中分析和比较了 LSG 前后铁与甲状腺激素之间的关系:1)总三碘甲状腺原氨酸(TT3)在高铁组明显高于低铁组(P = 0.008)。高铁组女性的总三碘甲状腺原氨酸(TT3)和促甲状腺激素(TSH)明显高于低铁组(1.92 ± 0.61 vs. 1.69 ± 0.28 nmol/l,P = 0.029;2.93 ± 1.66 vs. 1.88 ± 1.03 mU/l,P = 0.002),而男性则没有差异(均 P > 0.05)。2)铁与游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、TT3 和促甲状腺激素呈明显正相关(均为 P 结论:血清铁超载与肥胖症患者甲状腺功能受损密切相关。LSG可改善甲状腺功能,而甲状腺功能的改善与铁的变化有关:NCT04548232注册日期为2022年10月9日,注册网址为https://register.Clinicaltrials: gov/ .
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引用次数: 0
Relationship of different metabolic obesity phenotypes with reflux esophagitis: a propensity score matching analysis. 不同代谢性肥胖表型与反流性食管炎的关系:倾向得分匹配分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-07 DOI: 10.1186/s12902-024-01771-6
Tao He, Peng Wang, Li-Xia Wang, Meng-Han Tong, Zhi-Jun Duan

Background: Obesity is associated with an increased risk of reflux esophagitis (RE). Metabolic abnormalities have been implicated in the pathogenesis of RE. However, the role of metabolic status in the risk of RE among individuals with varying degrees of obesity remains unclear. Therefore, our study aimed to assess the association between metabolic obesity phenotypes and the risk of RE.

Methods: This study included a cohort of 24,368 participants aged 18 years and older who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital of Dalian Medical University during health checkups between January 1, 2008, and December 31, 2021. Among these participants, a total of 9,947 individuals were classified into four groups based on their obesity phenotype: metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO). To account for potential confounding factors, multivariate logistic regression analysis was applied to examine the association between metabolic obesity phenotypes and the risk of RE, with stratification by sex and age.

Results: Among all participants, the MUNW, MHO, and MUO groups demonstrated a higher risk of RE when compared to the MHNW group. After controlling for all confounding factors, the MUO group exhibited the highest risk, with an odds ratio (OR) of 3.723 (95% CI: 2.751-5.040) in males and 5.482 (95% CI: 4.080-7.367) in females. The prevalence of RE increased in proportion to the number of metabolic risk factors. Subgroup analyses, which accounted for all confounders, revealed that the MHO, MUNW, and MUO phenotypes were associated with an elevated risk of RE in individuals under 60 years old as well as those over 60 years old. Interestingly, a more comprehensive analysis indicated that obesity may have a greater effect on the risk of RE than metabolic disorders.

Conclusions: Both metabolic disorders and obesity were associated with an increased risk of RE. The effect of obesity on RE prevalence may be stronger than that of metabolic disorders, emphasizing the significance of obesity regardless of metabolic health status. Clinical interventions should address not only obesity but also metabolic disorders in order to reduce the risk of RE.

背景:肥胖与反流性食管炎(RE)风险增加有关。代谢异常与反流性食管炎的发病机制有关。然而,新陈代谢状况在不同肥胖程度的人中发生反流性食管炎的风险中所起的作用仍不清楚。因此,我们的研究旨在评估代谢性肥胖表型与RE风险之间的关联:本研究纳入了2008年1月1日至2021年12月31日期间在大连医科大学附属第一医院健康体检期间接受上消化道内镜检查的24368名18岁及以上参与者。根据肥胖表型将其中的9947人分为四组:代谢健康正常体重组(MHNW)、代谢健康肥胖组(MHO)、代谢不健康正常体重组(MUNW)和代谢不健康肥胖组(MUO)。为了考虑潜在的混杂因素,研究人员采用了多变量逻辑回归分析来研究代谢性肥胖表型与RE风险之间的关系,并按性别和年龄进行了分层:在所有参与者中,MUNW、MHO和MUO组的RE风险高于MHNW组。在控制了所有干扰因素后,MUO 组的风险最高,男性的几率比(OR)为 3.723(95% CI:2.751-5.040),女性的几率比(OR)为 5.482(95% CI:4.080-7.367)。RE发病率的增加与代谢风险因素的数量成正比。考虑了所有混杂因素的分组分析显示,MHO、MUNW 和 MUO 表型与 60 岁以下和 60 岁以上人群的 RE 风险升高有关。有趣的是,一项更全面的分析表明,肥胖对RE风险的影响可能大于代谢紊乱:结论:代谢紊乱和肥胖都与RE风险增加有关。肥胖对 RE 患病率的影响可能比代谢紊乱的影响更大,这强调了肥胖的重要性,无论代谢健康状况如何。临床干预措施不仅应针对肥胖,还应针对代谢紊乱,以降低RE的风险。
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引用次数: 0
Assessing the validity of METS-IR for predicting the future onset of diabetes: an analysis using time-dependent receiver operating characteristics. 评估 METS-IR 预测未来糖尿病发病的有效性:使用时间依赖性接收器操作特征进行分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-07 DOI: 10.1186/s12902-024-01769-0
Jiajun Qiu, Shiming He, Changhui Yu, Ruijuan Yang, Maobin Kuang, Guotai Sheng, Yang Zou

Background: The Metabolic Insulin Resistance Score (METS-IR) is a non-invasive proxy for insulin resistance (IR) that has been newly developed in recent years and has been shown to be associated with diabetes risk. Our aim was to assess the predictive value of METS-IR for the future development of diabetes and its temporal differences in people of different sex, age, and body mass index (BMI).

Methods: The current study included 15,453 baseline non-diabetic subjects in the NAGALA cohort and then grouped according to the World Health Organization's (WHO) recommended criteria for age and BMI. Multivariate Cox regression and time-dependent receiver operator characteristics (ROC) curves were used to analyze the value of METS-IR in assessing and predicting the risk of diabetes in people of different sexes, ages, and BMIs.

Results: 373 individuals developed diabetes during the observation period. By multivariate COX regression analysis, the development of future diabetes was significantly associated with increased METS-IR, and this positive association was stronger in women than in men and in individuals < 45 years than in individuals ≥ 45 years; while no significant differences were observed between non-obese and overweight/obesity individuals. Using time-dependent ROC analysis we also assessed the predictive value of METS-IR for future diabetes at a total of 11-time points between 2 and 12 years. The results showed that METS-IR had a higher predictive value for the future development of diabetes in women or individuals < 45 years of age compared to men or individuals ≥ 45 years of age for almost the entire follow-up period. Furthermore, across different BMI categories, we also found that in the short term (3-5 years), METS-IR had a higher predictive value for the development of diabetes in individuals with overweight/obesity, while in the medium to long term (6-12 years), METS-IR was more accurate in predicting the development of diabetes in non-obese individuals.

Conclusions: Our study showed that METS-IR was independently associated with the development of future diabetes in a non-diabetic population. METS-IR was a good predictor of diabetes, especially for women and individuals < 45 years old for predicting the future risk of developing diabetes at all times.

背景:代谢胰岛素抵抗评分(METS-IR)是近年来新开发的胰岛素抵抗(IR)的无创替代指标,已被证明与糖尿病风险有关。我们的目的是评估 METS-IR 对未来糖尿病发展的预测价值及其在不同性别、年龄和体重指数(BMI)人群中的时间差异:本研究纳入了 NAGALA 队列中的 15,453 名基线非糖尿病受试者,然后根据世界卫生组织(WHO)推荐的年龄和体重指数标准进行分组。采用多变量 Cox 回归和时间依赖性接收器运算特性曲线(ROC)来分析 METS-IR 在评估和预测不同性别、年龄和体重指数人群罹患糖尿病风险方面的价值:结果:观察期间有 373 人罹患糖尿病。通过多变量 COX 回归分析,未来糖尿病的发生与 METS-IR 的增加显著相关,而且这种正相关性在女性和个体中均强于男性:我们的研究表明,在非糖尿病人群中,METS-IR 与未来糖尿病的发生有独立关联。METS-IR 是糖尿病的良好预测指标,尤其是对女性和个体而言。
{"title":"Assessing the validity of METS-IR for predicting the future onset of diabetes: an analysis using time-dependent receiver operating characteristics.","authors":"Jiajun Qiu, Shiming He, Changhui Yu, Ruijuan Yang, Maobin Kuang, Guotai Sheng, Yang Zou","doi":"10.1186/s12902-024-01769-0","DOIUrl":"10.1186/s12902-024-01769-0","url":null,"abstract":"<p><strong>Background: </strong>The Metabolic Insulin Resistance Score (METS-IR) is a non-invasive proxy for insulin resistance (IR) that has been newly developed in recent years and has been shown to be associated with diabetes risk. Our aim was to assess the predictive value of METS-IR for the future development of diabetes and its temporal differences in people of different sex, age, and body mass index (BMI).</p><p><strong>Methods: </strong>The current study included 15,453 baseline non-diabetic subjects in the NAGALA cohort and then grouped according to the World Health Organization's (WHO) recommended criteria for age and BMI. Multivariate Cox regression and time-dependent receiver operator characteristics (ROC) curves were used to analyze the value of METS-IR in assessing and predicting the risk of diabetes in people of different sexes, ages, and BMIs.</p><p><strong>Results: </strong>373 individuals developed diabetes during the observation period. By multivariate COX regression analysis, the development of future diabetes was significantly associated with increased METS-IR, and this positive association was stronger in women than in men and in individuals < 45 years than in individuals ≥ 45 years; while no significant differences were observed between non-obese and overweight/obesity individuals. Using time-dependent ROC analysis we also assessed the predictive value of METS-IR for future diabetes at a total of 11-time points between 2 and 12 years. The results showed that METS-IR had a higher predictive value for the future development of diabetes in women or individuals < 45 years of age compared to men or individuals ≥ 45 years of age for almost the entire follow-up period. Furthermore, across different BMI categories, we also found that in the short term (3-5 years), METS-IR had a higher predictive value for the development of diabetes in individuals with overweight/obesity, while in the medium to long term (6-12 years), METS-IR was more accurate in predicting the development of diabetes in non-obese individuals.</p><p><strong>Conclusions: </strong>Our study showed that METS-IR was independently associated with the development of future diabetes in a non-diabetic population. METS-IR was a good predictor of diabetes, especially for women and individuals < 45 years old for predicting the future risk of developing diabetes at all times.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"238"},"PeriodicalIF":2.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study. BCAA 与 2 型糖尿病患者内脏脂肪面积的关系比皮下脂肪面积更密切:一项横断面研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-06 DOI: 10.1186/s12902-024-01768-1
Xinghua Cai, Wenmin Li, Liang Wang, Yingying Shi, Jie Gao, Hongping Wang, Tao Lei, Jun Lu

Background: Branched-chain amino acid (BCAA) has been reported to be associated with obesity, the association of BCAA with visceral fat area (VFA) and subcutaneous fat area (SFA) remained unclear in patients with type 2 diabetes.

Methods: This cross-sectional study was conducted in 284 patients with type 2 diabetes mellitus. Enzyme-linked immunospecific assay was used to measure levels of serum BCAA and branched-chain keto acid (BCKA). VFA and SFA were measured with bio-impedance analysis method. The association between BCAA and VFA was calculated using Pearson correlation and multivariable linear regression analysis.

Results: There were significant differences in the means of body mass index, waist circumstance, SFA and VFA among the three groups divided by total BCAA tertiles (all p < 0.05). Compared to patients with lower levels of serum BCAA (the lower tertile group), the means of VFA and SFA were significantly larger in the middle and upper tertile groups (all p < 0.05). However, the differences in above obesity parameters were nonsignificant according to various BCKA tertiles. Pearson correlation analysis also demonstrated that BCAA levels were positive associated with each obesity parameter (p < 0.05). Nevertheless, multivariable linear regression analysis showed that levels of serum BCAA were correlated with VFA, BMI and WC (all p < 0.05) rather than SFA after adjusted for other confounders.

Conclusions: levels of serum BCAA were more closely correlated with VFA than SFA, prospective studies should be warranted to further explore the mechanism mediating BCAA and visceral fat accumulation in Human beings.

Clinical trial number: Not applicable.

背景:有报道称支链氨基酸(BCAA)与肥胖有关,但在2型糖尿病患者中,BCAA与内脏脂肪面积(VFA)和皮下脂肪面积(SFA)的关系仍不清楚:这项横断面研究在 284 名 2 型糖尿病患者中进行。采用酶联免疫特异性测定法测量血清 BCAA 和支链酮酸 (BCKA) 的水平。用生物阻抗分析方法测量了VFA和SFA。采用皮尔逊相关分析和多变量线性回归分析计算了 BCAA 和 VFA 之间的关系:结论:血清 BCAA 水平与 VFA 的相关性比与 SFA 的相关性更密切,应开展前瞻性研究,进一步探讨 BCAA 与人类内脏脂肪堆积的中介机制:不适用。
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引用次数: 0
Investigation of homocysteine level after bariatric metabolic surgery, effect on vitamin B12 and folate levels. 调查减肥代谢手术后的同型半胱氨酸水平,以及对维生素 B12 和叶酸水平的影响。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-06 DOI: 10.1186/s12902-024-01773-4
Çağlar Şahin, Yunushan Furkan Aydoğdu, Çağrı Büyükkasap, Kürşat Dikmen, Aydın Dalgıç

Background: Obesity is a serious health problem with increasing incidence. worldwide and remains one of the most important causes of preventable deaths. We aimed to examine the relationship between Vitamin B12 and Folic acid, which have an important role for human life, and homocysteine is widely recognized for its association with the development of cardiovascular disease, although its role as an independent risk factor remains a topic of ongoing debate.

Materials and methods: We evaluated 126 patients who underwent bariatric metabolic surgery between September 2019-September 2020. In addition to demographic characteristics of the patients, weight, Vitamin B12, folate, HbA1c, cholesterol, triglyceride, ferritin, serum iron, albumin levels at preoperative, postoperative 1st month, 6th month, 12th month follow-ups were analyzed.

Results: Patients with the desired biochemical parameters at the determined follow-up points were identified and two groups were formed as RYGB(n = 43) and SG(n = 7) patients. When biochemical parameters were analyzed between the groups, homocysteine, HbA1c, HDL Cholesterol, VLDL Cholesterol, Total Cholesterol, Triglycerides, Ferritin, Serum Iron levels showed a statistical difference (p < 0.001). Folate (p = 0.064) and albumin (p = 0.257) did not show a significant difference over time. The change in vitamin B12 (p = 0.409) over time was not significant in the SG group, whereas a significant difference was observed in the RYGB group (p < 0.001). When we established a marginal model to determine the factors affecting the change in homocysteine over time, vitamin B12 and folate values.

Conclusions: The relationship between Vitamin B12, folate and homocysteine is important in order to better understand the complications that develop in bariatric metabolic surgery patients, to prevent possible complications and to better manage the process.

背景:肥胖症是一个严重的健康问题,其发病率在全球范围内不断上升,并且仍然是导致可预防死亡的最重要原因之一。我们旨在研究维生素 B12 和叶酸与同型半胱氨酸之间的关系,维生素 B12 和叶酸对人类生命具有重要作用,而同型半胱氨酸因其与心血管疾病的发生相关而被广泛认可,尽管其作为独立风险因素的作用仍是一个持续争论的话题:我们对 2019 年 9 月至 2020 年 9 月期间接受减肥代谢手术的 126 名患者进行了评估。除了患者的人口统计学特征外,还分析了术前、术后第 1 个月、第 6 个月、第 12 个月随访时的体重、维生素 B12、叶酸、HbA1c、胆固醇、甘油三酯、铁蛋白、血清铁、白蛋白水平:结果:在确定的随访时间点,确定了具有理想生化指标的患者,并将其分为两组,即 RYGB(43 例)和 SG(7 例)患者。在对两组患者的生化指标进行分析时,同型半胱氨酸、HbA1c、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、铁蛋白、血清铁水平均显示出统计学差异(P 结论:维生素 B12 和叶酸之间的关系是有统计学意义的:维生素 B12、叶酸和同型半胱氨酸之间的关系对于更好地了解减肥代谢手术患者出现的并发症、预防可能出现的并发症和更好地管理手术过程非常重要。
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引用次数: 0
Increased risk of vascular complications in patients with type 2 diabetes and fatty liver disease. 2 型糖尿病和脂肪肝患者出现血管并发症的风险增加。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-05 DOI: 10.1186/s12902-024-01766-3
Weixia Sun, Dechen Liu, Ting Yang, Ziwei Zhou, Dan Li, Zhuoxiao Zhao, Xuan Zhang, Liyun Wang, Ling Li

Background: The prevalence of steatotic liver disease (SLD) in patients with type 2 diabetes (T2DM) exceeds 50%. This study aimed to investigate the clinical characteristics of SLD and liver fibrosis in Chinese patients with T2DM.

Methods: Inpatients from 2021 to 2023 were included in the study. Fatty liver index (FLI) and fibrosis-4 (FIB-4) were calculated to assess hepatic steatosis and fibrosis respectively. Statistical analysis was completed by SPSS v25 and GraphPad Prism v8.0.1.

Results: Of the 1466 participants, about one-third of the patients in T2DM-SLD group were diagnosed with liver fibrosis (LF), and the percentage of patients over 50 years old was 85.9%. Patients with SLD had higher levels of BMI, blood pressure, liver enzymes, fasting blood glucose (FBG), HbA1c, C-peptide, total cholesterol (TC) and triglyceride (TG) (P<0.05 for all). Patients with liver fibrosis had lower TC, TG, hemoglobin (Hb), erythrocyte count (RBC), leukocyte count (WBC) and platelet (PLT) levels (P<0.05 for all). Compared with simple T2DM and SLD-NLF (non-liver fibrosis) groups, for patients over 50 years old, the prevalence of coronary heart disease, stroke, tumor, and diabetic nephropathy was higher in patients with liver fibrosis. Liver fibrosis might be the risk factor of arterial stiffness, stroke, coronary heart disease and numbness based on multivariable logistic regression analysis.

Conclusion: Hepatic steatosis and fibrosis were common in patients with T2DM. Liver fibrosis was relevant to many macrovascular and microvascular diabetic complications.

背景:2型糖尿病(T2DM)患者中脂肪性肝病(SLD)的发病率超过50%。本研究旨在调查中国 T2DM 患者脂肪肝和肝纤维化的临床特征:研究纳入了 2021 年至 2023 年的住院患者。脂肪肝指数(FLI)和肝纤维化-4(FIB-4)分别用于评估肝脏脂肪变性和肝纤维化。统计分析由 SPSS v25 和 GraphPad Prism v8.0.1 完成:在1466名参与者中,T2DM-SLD组约三分之一的患者被诊断为肝纤维化(LF),50岁以上的患者占85.9%。SLD患者的体重指数(BMI)、血压、肝酶、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、C肽、总胆固醇(TC)和甘油三酯(TG)水平均较高:肝脏脂肪变性和纤维化在 T2DM 患者中很常见。肝纤维化与许多糖尿病大血管和微血管并发症有关。
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引用次数: 0
The association between triglyceride-glucose index combined with obesity indicators and stroke risk: A longitudinal study based on CHARLS data. 甘油三酯-葡萄糖指数结合肥胖指标与中风风险之间的关系:基于 CHARLS 数据的纵向研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-01 DOI: 10.1186/s12902-024-01729-8
Weicai Liang, Haichun Ouyang

Background and objective: The triglyceride-glucose (TyG) index, a surrogate marker for insulin resistance, has been proposed as a predictor of cardiovascular events. However, the combined impact of the TyG index and obesity indicators, such as body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), on stroke risk was not fully understood. This study aimed to investigate the association between the TyG index combined with these obesity indicators and stroke risk in the Chinese population.

Materials and methods: Data on 17,708 participants aged 45 years or older for this study were collected from the China Health and Retirement Longitudinal Study (CHARLS) from baseline (2011) to the Wave 5 follow-up (2020). Cox proportional hazards model, restricted cubic spline (RCS) and receiver operating characteristic (ROC) analysis were employed to examine the association between the TyG index and its combined obesity-related indicators with stroke. Mediation analysis was conducted to explore the mutual potential mediating role of TyG and obesity indicators in the above relationships.

Results: A total of 8,207 participants with an average age of 58.2 years were investigated, of which 11.0% were stroke individuals, 44.80% were men and 84.6% were from rural areas. TyG, TyG-BMI, TyG-WHtR, TyG-WC were significantly higher in stroke subjects than in the non-stroke subjects (P < 0.001), and were significantly and positively associated with stroke in all 3 models (P < 0.05). Restricted cubic spline models revealed nonlinear associations between TyG and TyG-BMI with stroke (P-overall < 0.001, P-nonlinear = 0.003 for TyG, and P-overall < 0.001, P-nonlinear = 0.028 for TyG-BMI), while TyG-WC and TyG-WHtR (P-overall < 0.001 and P-nonlinear > 0.05) demonstrated linear associations with stroke after adjusting for covariates. TyG-WHtR, TyG-BMI and TyG-WC had more robust predictive power than TyG for risk of stroke. TyG-WHtR or TyG-WC had the highest predictive power for stroke (AUC:0.696, 95% CI 0.677-0.715), slightly higher than the other indicators. Associations between TyG, TyG-WC, TyG-WHtR, and TyG-BMI with stroke were found to be stronger among individuals who were ≥ 55 years of age, male. The relationship between TyG and stroke was significantly mediated by BMI, WHtR and WC (15.79%, 21.72%, and 24.06% respectively), while the relationship between these obesity measures and stroke was significantly mediated by TyG (18.48%, 14.45%, and 14.70% respectively).

Conclusion: The combination of TyG and obesity-related indicators was significantly associated with stroke risk, and could improve predictive power for stroke compared to the single TyG. Obesity indicators and TyG mediated each other in their respective associations with stroke risk.

背景和目的:甘油三酯-葡萄糖(TyG)指数是胰岛素抵抗的替代指标,已被提出作为心血管事件的预测指标。然而,TyG 指数和肥胖指标(如体重指数 (BMI)、腰围 (WC) 和腰围身高比 (WHtR))对卒中风险的综合影响尚未完全明了。本研究旨在调查中国人群中 TyG 指数与这些肥胖指标之间的关系:中国健康与退休纵向研究(CHARLS)从基线(2011 年)到第五波随访(2020 年)收集了 17708 名 45 岁及以上参与者的数据。采用 Cox 比例危险度模型、限制性立方样条曲线(RCS)和接收者操作特征(ROC)分析来研究 TyG 指数及其肥胖相关综合指标与脑卒中的关系。研究还进行了中介分析,以探讨TyG和肥胖指标在上述关系中的潜在中介作用:共调查了 8207 名参与者,平均年龄为 58.2 岁,其中 11.0% 为脑卒中患者,44.80% 为男性,84.6% 来自农村地区。中风受试者的 TyG、TyG-BMI、TyG-WHtR、TyG-WC 显著高于非中风受试者(P 0.05),在调整协变量后显示出与中风的线性相关。与 TyG 相比,TyG-WHtR、TyG-BMI 和 TyG-WC 对中风风险的预测能力更强。TyG-WHtR或TyG-WC对卒中的预测能力最高(AUC:0.696,95% CI 0.677-0.715),略高于其他指标。TyG、TyG-WC、TyG-WHtR 和 TyG-BMI 与脑卒中的关系在年龄≥ 55 岁的男性中更为密切。TyG与脑卒中之间的关系受BMI、WHtR和WC的显著介导(分别为15.79%、21.72%和24.06%),而这些肥胖指标与脑卒中之间的关系受TyG的显著介导(分别为18.48%、14.45%和14.70%):结论:TyG 和肥胖相关指标的组合与脑卒中风险显著相关,与单一 TyG 相比,可提高对脑卒中的预测能力。肥胖指标和TyG在各自与脑卒中风险的关联中起着相互中介的作用。
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引用次数: 0
The association between parity and type 2 diabetes mellitus: a cross-sectional, community-based study. 奇偶性与 2 型糖尿病之间的关系:一项基于社区的横断面研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-31 DOI: 10.1186/s12902-024-01767-2
Imad R Musa, Osman E Osman, Ishag Adam

Background: Limited published data exist on the association between parity (number of deliveries) and diabetes mellitus (DM). This study was conducted to evaluate the association between parity and type 2 DM (T2DM) among Sudanese women.

Method: A multistage sampling survey was conducted in four villages in the River Nile State, Sudan, between July and September 2022. The World Health Organization's three-level stepwise questionnaire was adopted to collect women's sociodemographic characteristics (age, sex, height, weight, marital status, parity, education level, occupation, detailed obstetric history, and family history of T2DM). Multivariate analyses were performed.

Results: A total of 397 women were recruited. Their median (interquartile range) age was 45.0 (33.0‒55.7) years. A total of 154 women (38.8%) were nulliparous, whereas 93 (23.4%), 70 (17.6%), and 80 (20.2%) had para 1‒3, 4 or 5, and more than 5, respectively. A total of 112 (28.2%) women had T2DM. In multivariate analysis, older age (adjusted odds ratio, AOR, 1.04, 95%, confidence interval, CI, 1.02‒1.06), high parity (AOR, 1.1, 95% C, 1.01‒1.20), and a family history of DM (AOR, 3.26, 95% CI, 1.98‒5.38) were associated with T2DM. Compared with the nulliparity, para 1‒3 (AOR, 2.33; 95% CI, 1.17‒4.61), para 4 or 5 (AOR, 2.12; 95% CI, 1.04‒4.30), and para > 5 (AOR, 2.16; 95% CI, 1.09‒4.27) were at higher risk of T2DM. In women aged < 50 years, high parity (AOR, 1.22; 95% CI, 1.06‒1.44) was associated with T2DM. Compared with the nulliparous women, para 4 or 5 (AOR, 3.47; 95% CI, 1.16‒10.34) and para > 5 (AOR, 4.63; 95% CI, 1.54‒13.87) were associated with T2DM, whereas para 1‒3 was not associated with T2DM. In the women aged ≥ 50 years, parity and parity groups were not associated with T2DM.

Conclusion: There is a high prevalence of T2DM among Sudanese women. Parity and high parity are significant predictors of T2DM among these women in this part of Sudan.

背景:已发表的关于准妈妈(分娩次数)与糖尿病(DM)之间关系的数据有限。本研究旨在评估苏丹妇女的奇偶性与 2 型糖尿病(T2DM)之间的关系:方法:2022 年 7 月至 9 月期间,在苏丹尼罗河州的四个村庄进行了多阶段抽样调查。采用世界卫生组织的三级递进式问卷调查法收集妇女的社会人口学特征(年龄、性别、身高、体重、婚姻状况、胎次、教育程度、职业、详细的产科病史和 T2DM 家族史)。进行了多变量分析:结果:共招募了 397 名妇女。结果:共招募了 397 名妇女,其年龄中位数(四分位数间距)为 45.0(33.0-55.7)岁。共有 154 名妇女(38.8%)为空腹,93 名(23.4%)、70 名(17.6%)和 80 名(20.2%)分别有 1-3 段、4 或 5 段和 5 段以上。共有 112 名(28.2%)妇女患有 T2DM。在多变量分析中,年龄较大(调整后的几率比,AOR,1.04,95% 置信区间,CI,1.02-1.06)、高妊娠率(AOR,1.1,95% C,1.01-1.20)和糖尿病家族史(AOR,3.26,95% CI,1.98-5.38)与 T2DM 相关。与无生育史的妇女相比,1-3 段(AOR,2.33;95% CI,1.17-4.61)、4 或 5 段(AOR,2.12;95% CI,1.04-4.30)和 5 段以上(AOR,2.16;95% CI,1.09-4.27)的妇女患 T2DM 的风险更高。5 岁(AOR,4.63;95% CI,1.54-13.87)的妇女与 T2DM 有关,而 1-3 岁与 T2DM 无关。结论:在年龄≥50 岁的妇女中,准妈妈和准妈妈组与 T2DM 无关:结论:苏丹妇女的 T2DM 患病率很高。结论:苏丹妇女中 T2DM 的发病率很高,而在苏丹的这一地区,妇女患 T2DM 的一个重要预测因素是孕妇足月和高足月。
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BMC Endocrine Disorders
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