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Lipids as the link between central obesity and diabetes: perspectives from mediation analysis. 血脂是中心性肥胖与糖尿病之间的联系:中介分析的视角。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-28 DOI: 10.1186/s12902-024-01764-5
Song Lu, Maobin Kuang, Jiajun Qiu, Wenjuan Li, Min Zhang, Guotai Sheng, Yang Zou, Xiaoping Peng

Background: Central obesity is a well-recognized risk factor for diabetes, yet the potential role of lipids in the diabetes risk associated with central obesity remains unclear. This study aimed to explore the possible mediating role of 11 lipid parameters [high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), non-high-density lipoprotein cholesterol (Non-HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), remnant cholesterol (RC), and ratios of Non-HDL-C/HDL-C, RC/HDL-C, LDL/HDL-C, TG/HDL-C, TC/HDL-C] in the association of central obesity with diabetes risk.

Methods: We utilized data from 15,453 participants in the NAGALA longitudinal cohort to assess the association of baseline central obesity indicators [waist-height ratio (WHtR), waist circumference (WC)] and the 11 lipid parameters with diabetes risk. Mediation analysis models were constructed to explore the mediating role of lipid parameters in the association of WC/WHtR with diabetes.

Results: Confirmatory associative analysis using multivariable Cox regression showed that, except for Non-HDL-C, TC and LD-C, the remaining eight lipid parameters were significantly associated with WC/WHtR and diabetes risk. Mediation analysis indicated that TG, RC, HDL-C, and lipid ratios such as Non-HDL-C/HDL-C ratio, RC/HDL-C ratio, TG/HDL-C ratio, TC/HDL-C ratio and LDL/HDL-C ratio are potential lipids affecting the diabetes risk related to central obesity. Among these, the RC/HDL-C ratio seemed to contribute the most in the WC/WHtR-related diabetes risk association, with a mediation percentage of about 37%. Additionally, lipid ratio parameters appeared to play a more mediating role in the association of central obesity-related diabetes risk than individual lipids.

Conclusions: In central obesity-related diabetes risk, most lipids, especially lipid ratio parameters, play a significant mediating role. Given these findings, we advocate for increased efforts in multifactorial risk monitoring and joint management of diabetes. The evaluation of lipids, particularly lipid ratio parameters, may be holds substantial value in the prevention and management of diabetes risk under close monitoring of central obesity.

背景:中心性肥胖是公认的糖尿病风险因素,但血脂在与中心性肥胖相关的糖尿病风险中的潜在作用仍不清楚。本研究旨在探讨 11 种血脂参数(高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、非高密度脂蛋白胆固醇(Non-HDL-C)低密度脂蛋白胆固醇 (LDL-C)、甘油三酯 (TG)、残余胆固醇 (RC) 以及非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇、RC/高密度脂蛋白胆固醇、低密度脂蛋白/高密度脂蛋白胆固醇、TG/高密度脂蛋白胆固醇、TC/高密度脂蛋白胆固醇的比率]等 11 项血脂参数在中心性肥胖与糖尿病风险的关联中的作用。方法:我们利用 NAGALA 纵向队列中 15,453 名参与者的数据,评估了基线中心性肥胖指标[腰高比(WHtR)、腰围(WC)]和 11 项血脂参数与糖尿病风险的关系。建立了中介分析模型,以探讨血脂参数在腰围/腰围比与糖尿病的关联中的中介作用:结果:使用多变量考克斯回归进行的确证关联分析表明,除非高密度脂蛋白胆固醇(Non-HDL-C)、总胆固醇(TC)和低密度脂蛋白胆固醇(LD-C)外,其余8个血脂参数与体重/体重指数和糖尿病风险显著相关。中介分析表明,TG、RC、HDL-C 以及非 HDL-C/HDL-C 比值、RC/HDL-C 比值、TG/HDL-C 比值、TC/HDL-C 比值和 LDL/HDL-C 比值等血脂比率是影响中心性肥胖相关糖尿病风险的潜在血脂参数。其中,RC/HDL-C 比值似乎在与 WC/WHtR 相关的糖尿病风险关联中贡献最大,调解比例约为 37%。此外,与单个血脂相比,血脂比率参数似乎在中心性肥胖相关糖尿病风险关联中发挥着更大的中介作用:结论:在中枢性肥胖相关糖尿病风险中,大多数血脂,尤其是血脂比率参数,起着重要的中介作用。鉴于这些发现,我们主张加大多因素风险监测和糖尿病联合管理的力度。在密切监测中心性肥胖的情况下,评估血脂,尤其是血脂比率参数,对预防和管理糖尿病风险具有重要价值。
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引用次数: 0
To analyse the correlation between UAER and eGFR and the risk factors for reducing eGFR in patients with type 2 diabetes. 分析 2 型糖尿病患者的 UAER 和 eGFR 之间的相关性,以及降低 eGFR 的风险因素。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-28 DOI: 10.1186/s12902-024-01761-8
Haihui Li, Lanwen Han, Xia Gao

Objective: To analyse the correlation between urinary albumin excretion rate (UAER) and estimated glomerular filtration rate (eGFR) and the risk factors for reducing eGFR in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 431 T2DM patients admitted between January 2019 and March 2020 were selected and divided into two groups according to eGFR level. Comparing the differences between baseline data and clinical indicators, multivariate logistic regression was used to analyse the risk factors of eGFR reduction and to analyse the association between UAER and eGFR.

Results: In total, 167 patients were included in the study group and 264 patients were included in the conventional group. The study group participants were older, had longer diabetes duration, and had higher fatty liver, peripheral vascular disease (PVD), hypertension prevalence, and mean body mass index (P < 0.05). The levels of various indicators were lower than those of the conventional group (P < 0. 05). Additionally, PVD, nocturnal systolic blood pressure, fatty liver, and beta-2-microglobulin (β 2-MG) were independent risk factors for eGFR decline, with high density lipoprotein (HDL) and fasting C-peptide (CP) as protective factors. There was no obvious correlation between UAER and eGFR.

Conclusion: Peripheral vascular disease, systolic blood pressure, fatty liver, and beta-2-microglobulin are risk factors for decreased eGFR levels in patients with T2DM, which should be applied for control DKD. HDL and fasting CP have important effects on maintaining eGFR, and blood pressure and fasting CP can be used as new targets for subsequent diabetic kidney disease treatment.

目的分析2型糖尿病(T2DM)患者尿白蛋白排泄率(UAER)与估计肾小球滤过率(eGFR)之间的相关性以及降低eGFR的风险因素:选取2019年1月至2020年3月期间收治的431名T2DM患者,根据eGFR水平分为两组。比较基线数据与临床指标之间的差异,采用多变量逻辑回归分析 eGFR 降低的风险因素,并分析 UAER 与 eGFR 之间的关联:研究组共纳入 167 名患者,常规组共纳入 264 名患者。外周血管疾病、收缩压、脂肪肝和β-2-微球蛋白是导致T2DM患者eGFR水平下降的危险因素,因此应控制DKD。高密度脂蛋白和空腹血脂对维持 eGFR 有重要影响,血压和空腹血脂可作为后续糖尿病肾病治疗的新目标。
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引用次数: 0
Red cell distribution width/albumin ratio as a marker for metabolic syndrome: findings from a cross-sectional study. 作为代谢综合征标志物的红细胞分布宽度/白蛋白比率:一项横断面研究的结果。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-25 DOI: 10.1186/s12902-024-01762-7
Hao Guo, Yu Wang, Ying Miao, Qiang Lin

Background: Metabolic syndrome (MetS) imposes a significant health burden on patients globally. Chronic low-grade inflammation is pivotal in the onset and progression of this condition. However, the role of the novel inflammatory marker, red cell distribution width to albumin ratio (RAR), in the development of MetS remains unclear.

Methods: This population-based cross-sectional study utilized data from the 2011-2020 National Health and Nutrition Examination Survey (NHANES). Participants included individuals over 18 years old with complete data on serum albumin concentration, red cell distribution, and MetS and its components. MetS was defined using the criteria established by the National Cholesterol Education Program Adult Treatment Panel III. The calculation formula for RAR is: RAR = Red cell distribution width (%)/serum albumin (g/dL). Study participants were stratified into four quartiles based on RAR levels. Logistic regression analysis and subgroup analysis were employed to explore the independent interaction between RAR and MetS, as well as investigate the relationship between RAR levels and the specific components of MetS. Finally, the receiver operating characteristic (ROC) curve was used to assess the predictive efficacy of RAR for MetS.

Results: A total of 4899 participants were included in this study, comprising 2450 males and 2449 females; 1715 individuals (35.01%) were diagnosed with MetS. As the quartile of RAR increased, the proportion of individuals with MetS also increased. Spearman correlation analysis indicated a positive correlation between RAR and the insulin resistance index HOMA-IR. Logistic regression analysis, adjusting for multiple confounding factors, showed that each standard deviation increase in RAR was associated with a significant 1.665-fold increase (95% CI, 1.404-1.975; P < 0.001) in the odds of MetS prevalence. In logistic regression analysis stratified by quartiles of RAR, the risks of MetS in Q1-Q4 were 1.372 (95% CI, 1.105-1.704; P = 0.004), 1.783 (95% CI, 1.434-2.216; P < 0.001), and 2.173 (95% CI, 1.729-2.732; P < 0.001), respectively. Subgroup analyses and interaction tests demonstrated that gender, age, race, education, smoking status, and physical activity modified the positive association between RAR and MetS (p for interaction < 0.05). Additionally, analysis of the area under the receiver operating characteristic (ROC) curve showed that the optimal cutoff value for predicting MetS using RAR was 3.1348 (sensitivity: 59.9%; specificity: 60.6%; and AUC: 0.628).

Conclusions: Increasing RAR levels are associated with a higher risk of MetS. Therefore, greater attention should be given to patients with high RAR levels for improved prevention and treatment of MetS.

背景:代谢综合征(MetS代谢综合征(MetS)给全球患者带来了巨大的健康负担。慢性低度炎症是该病症发病和发展的关键因素。然而,新型炎症标志物--红细胞分布宽度与白蛋白比值(RAR)在代谢综合征发病中的作用仍不清楚:这项基于人群的横断面研究利用了 2011-2020 年美国国家健康与营养调查(NHANES)的数据。研究对象包括 18 岁以上、血清白蛋白浓度、红细胞分布、MetS 及其组成部分数据完整的个体。MetS 的定义采用美国国家胆固醇教育计划成人治疗小组 III 制定的标准。RAR 的计算公式为RAR = 红细胞分布宽度(%)/血清白蛋白(克/分升)。研究参与者根据 RAR 水平被分为四个四分位数。采用逻辑回归分析和亚组分析来探讨 RAR 与 MetS 之间的独立交互作用,并研究 RAR 水平与 MetS 特定成分之间的关系。最后,采用接收者操作特征曲线(ROC)评估 RAR 对 MetS 的预测效果:本研究共纳入 4899 名参与者,其中男性 2450 人,女性 2449 人;1715 人(35.01%)被诊断为 MetS。随着 RAR 四分位数的增加,MetS 患者的比例也在增加。斯皮尔曼相关分析表明,RAR 与胰岛素抵抗指数 HOMA-IR 呈正相关。调整多种混杂因素的逻辑回归分析表明,RAR 每增加一个标准差,MetS 患者的比例就会显著增加 1.665 倍(95% CI,1.404-1.975;P 结论:RAR 水平的增加与胰岛素抵抗指数 HOMA-IR 呈正相关:RAR 水平的升高与 MetS 风险的升高有关。因此,应更加关注 RAR 水平高的患者,以改善 MetS 的预防和治疗。
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引用次数: 0
The change in thyroid function categories with time in patients with subclinical hypothyroidism: a systematic review and meta-analysis. 亚临床甲减患者甲状腺功能分类随时间的变化:系统综述和荟萃分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-25 DOI: 10.1186/s12902-024-01754-7
Xueqi Zhang, Guofeng Zhang, Songwen Wang, Jing Jin, Shimiao Zhang, Xiaochun Teng

Background: Subclinical hypothyroidism (SCH) is characterized by elevated levels of thyroid hormone (TSH) and normal levels of free thyroxine (FT4). The outcomes of SCH patients are crucial for determining treatment plans; therefore, our aim is to summarize the existing prospective studies to understand the changes in thyroid function over time in SCH patients and the factors influencing these changes, providing references for clinical diagnosis and treatment.

Methods: We searched PubMed, Embase, Cochrane Library, and Web of Science for prospective follow-up studies on natural outcomes of SCH published until September 2024. Results are presented as the overall risk ratio (RR) and 95% confidence intervals (CI).

Results: We reviewed 8 prospective follow-up studies involving 1,859 individuals and extracted data from them for a meta-analysis. We found that when TSH levels are ≥ 10 mU/L, patients with SCH are more likely to progress to overt hypothyroidism (OH) (RR11.38, 95%CI 4.98-26.03, P<0.001) and were less likely to return to normal TSH levels (RR 0.20, 95%CI 0.09-0.42, P<0.001) compared to patients with TSH between 4.5 and 9.9 mU/L. In addition, patients who test positive for thyroid peroxidase antibodies (TPOAb) are more likely to progress to OH (RR 2.53, 95% CI 1.86-3.44, P < 0.001) and less likely to return to euthyroidism (RR 0.68, 95% CI 0.60-0.76, P < 0.001) compared to TPOAb-negative patients.

Conclusion: The results indicated that a large proportion of patients diagnosed with SCH will return to normal TSH levels or maintain SCH. Additionally, patients with TSH levels ≥ 10 mU/L or positive for TPOAb are more likely to experience progression and should be closely monitored. However, we did not find any gender differences in the natural outcome of SCH.

背景:亚临床甲状腺功能减退症(SCH)的特点是甲状腺激素(TSH)水平升高而游离甲状腺素(FT4)水平正常。SCH患者的治疗结果对于确定治疗方案至关重要;因此,我们的目的是总结现有的前瞻性研究,以了解SCH患者甲状腺功能随时间的变化以及影响这些变化的因素,为临床诊断和治疗提供参考:我们检索了PubMed、Embase、Cochrane Library和Web of Science上截至2024年9月发表的有关SCH自然结果的前瞻性随访研究。结果显示为总风险比(RR)和 95% 置信区间(CI):我们回顾了涉及 1859 人的 8 项前瞻性随访研究,并从中提取数据进行了荟萃分析。我们发现,当TSH水平≥10 mU/L时,SCH患者更有可能发展为明显甲状腺功能减退症(OH)(RR11.38,95%CI 4.98-26.03,PC结论:结果表明,大部分确诊为SCH的患者TSH水平将恢复正常或保持SCH。此外,TSH 水平≥ 10 mU/L 或 TPOAb 阳性的患者更有可能病情恶化,应密切监测。不过,我们并未发现SCH的自然结果存在性别差异。
{"title":"The change in thyroid function categories with time in patients with subclinical hypothyroidism: a systematic review and meta-analysis.","authors":"Xueqi Zhang, Guofeng Zhang, Songwen Wang, Jing Jin, Shimiao Zhang, Xiaochun Teng","doi":"10.1186/s12902-024-01754-7","DOIUrl":"10.1186/s12902-024-01754-7","url":null,"abstract":"<p><strong>Background: </strong>Subclinical hypothyroidism (SCH) is characterized by elevated levels of thyroid hormone (TSH) and normal levels of free thyroxine (FT4). The outcomes of SCH patients are crucial for determining treatment plans; therefore, our aim is to summarize the existing prospective studies to understand the changes in thyroid function over time in SCH patients and the factors influencing these changes, providing references for clinical diagnosis and treatment.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Cochrane Library, and Web of Science for prospective follow-up studies on natural outcomes of SCH published until September 2024. Results are presented as the overall risk ratio (RR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>We reviewed 8 prospective follow-up studies involving 1,859 individuals and extracted data from them for a meta-analysis. We found that when TSH levels are ≥ 10 mU/L, patients with SCH are more likely to progress to overt hypothyroidism (OH) (RR11.38, 95%CI 4.98-26.03, P<0.001) and were less likely to return to normal TSH levels (RR 0.20, 95%CI 0.09-0.42, P<0.001) compared to patients with TSH between 4.5 and 9.9 mU/L. In addition, patients who test positive for thyroid peroxidase antibodies (TPOAb) are more likely to progress to OH (RR 2.53, 95% CI 1.86-3.44, P < 0.001) and less likely to return to euthyroidism (RR 0.68, 95% CI 0.60-0.76, P < 0.001) compared to TPOAb-negative patients.</p><p><strong>Conclusion: </strong>The results indicated that a large proportion of patients diagnosed with SCH will return to normal TSH levels or maintain SCH. Additionally, patients with TSH levels ≥ 10 mU/L or positive for TPOAb are more likely to experience progression and should be closely monitored. However, we did not find any gender differences in the natural outcome of SCH.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance of circulating long non-coding RNA SNHG1 in type 2 diabetes mellitus and its association with cell proliferation of pancreatic β-cell. 循环长非编码 RNA SNHG1 在 2 型糖尿病中的临床意义及其与胰腺 β 细胞增殖的关系
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-25 DOI: 10.1186/s12902-024-01755-6
Tianxiang Xu, Tuwang Shen, Song Yang, Yuan Li, Li Liu, Lili Du

Background: To explore the association of long non-coding RNA (lncRNA) SNHG1/ miR-195 axis with type 2 diabetes mellitus (T2DM) and islet function.

Methods: The expression of SNHG1 and miR-195 was measured in T2DM patients and in healthy subjects. Correlation between indciators was evaluated using Pearson correlation analysis. INS-1 cells were used to perform the cell function assays. Insulin secretion by INS-1 was detected using ELISA. Cell counting kit-8 (CCK-8) and flow cytometry was used to detect cell proliferation and apoptosis. Luciferase report assay was to used to verify the target of SNHG1.

Results: The expression of SNHG1 was increased and miR-195 level was decreased in the serum of T2DM patients. Both SNHG1 and miR-195 could be biomarkers for T2DM diagnosis. The fasting plasma glucose (FPG) and HbA1c were positively related to SNHG1 and negatively related to miR-195. SNHG1 inhibited insulin secretion, and cell proliferation and promoted apoptosis of INS-1 cells via binding to miR-195.

Conclusions: Detection of SNHG1 and miR-195 might predict T2DM. SNHG1 could suppress proliferation and insulin secretion, but promote apoptosis of INS-1 cells via sponging miR-195.

背景:探讨长非编码RNA(lncRNA)SNHG1/ miR-195轴与2型糖尿病(T2DM)和胰岛功能的关系:探讨长非编码RNA(lncRNA)SNHG1/ miR-195轴与2型糖尿病(T2DM)和胰岛功能的关系:方法:测定T2DM患者和健康人体内SNHG1和miR-195的表达。采用皮尔逊相关分析评估指标之间的相关性。INS-1 细胞用于进行细胞功能测定。使用 ELISA 检测 INS-1 细胞分泌胰岛素的情况。细胞计数试剂盒-8(CCK-8)和流式细胞仪用于检测细胞增殖和凋亡。荧光素酶报告试验用于验证 SNHG1 的靶标:结果:T2DM 患者血清中 SNHG1 表达增加,miR-195 水平降低。SNHG1和miR-195均可作为诊断T2DM的生物标志物。空腹血浆葡萄糖(FPG)和 HbA1c 与 SNHG1 呈正相关,而与 miR-195 呈负相关。SNHG1 通过与 miR-195 结合抑制 INS-1 细胞的胰岛素分泌、细胞增殖并促进其凋亡:结论:检测 SNHG1 和 miR-195 可预测 T2DM。结论:SNHG1和miR-195的检测可预测T2DM,SNHG1可抑制INS-1细胞的增殖和胰岛素分泌,但通过与miR-195结合可促进INS-1细胞的凋亡。
{"title":"Clinical significance of circulating long non-coding RNA SNHG1 in type 2 diabetes mellitus and its association with cell proliferation of pancreatic β-cell.","authors":"Tianxiang Xu, Tuwang Shen, Song Yang, Yuan Li, Li Liu, Lili Du","doi":"10.1186/s12902-024-01755-6","DOIUrl":"10.1186/s12902-024-01755-6","url":null,"abstract":"<p><strong>Background: </strong>To explore the association of long non-coding RNA (lncRNA) SNHG1/ miR-195 axis with type 2 diabetes mellitus (T2DM) and islet function.</p><p><strong>Methods: </strong>The expression of SNHG1 and miR-195 was measured in T2DM patients and in healthy subjects. Correlation between indciators was evaluated using Pearson correlation analysis. INS-1 cells were used to perform the cell function assays. Insulin secretion by INS-1 was detected using ELISA. Cell counting kit-8 (CCK-8) and flow cytometry was used to detect cell proliferation and apoptosis. Luciferase report assay was to used to verify the target of SNHG1.</p><p><strong>Results: </strong>The expression of SNHG1 was increased and miR-195 level was decreased in the serum of T2DM patients. Both SNHG1 and miR-195 could be biomarkers for T2DM diagnosis. The fasting plasma glucose (FPG) and HbA1c were positively related to SNHG1 and negatively related to miR-195. SNHG1 inhibited insulin secretion, and cell proliferation and promoted apoptosis of INS-1 cells via binding to miR-195.</p><p><strong>Conclusions: </strong>Detection of SNHG1 and miR-195 might predict T2DM. SNHG1 could suppress proliferation and insulin secretion, but promote apoptosis of INS-1 cells via sponging miR-195.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between dietary phytochemical index and novel anthropometric indices and the severity of diabetic foot ulcers in adults with type 2 diabetes: a cross-sectional study. 膳食植物化学物指数和新型人体测量指数与 2 型糖尿病成人糖尿病足溃疡严重程度之间的关系:一项横断面研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-25 DOI: 10.1186/s12902-024-01734-x
Moharam Jalalzadeh, Ensieh Nasli-Esfahani, Mohsen Montazer, Faezeh Geravand, Parisa Nezhad Hajian, Mohammad Heidari-Seyedmahalle, Leila Azadbakht

Background: Research on the relationship between dietary phytochemical intake and the anthropometric indices as well as the diabetic foot ulcers (DFUs) remains inconsistent. We aimed to investigate the associations of dietary phytochemical index (DPI) with the novel anthropometric indices and the severity of DFUs.

Methods: This cross-sectional study was conducted on 339 adults with type 2 diabetes. Dietary intake was assessed using three 24-hour dietary recalls. To quantify the phytochemical content of the diet, the DPI estimation was done through an equation proposed by McCarty. The International Working Group on the Diabetic Foot (IWGDF) criteria and Wagner classification system were applied to assess DFUs. New anthropometric indices including a body shape index (ABSI), body roundness index (BRI) and abdominal volume index (AVI) were calculated based on formulas. We employed analysis of variance (ANOVA), analysis of covariance (ANCOVA) and logistic regression to explore associations between DPI and the anthropometric indices and DFU variables.

Results: Our results revealed no significant association between DPI and the foot ulcer indices, following adjusting for the possible covariates. Furthermore, we also examined the relationship between diabetic neuropathy, as measured by monofilament score, and the DPI. Similarly, we did not find any substantial relationship between the DPI and monofilament score (OR: 1.18; 95% CI: 0.66-2.09; Ptrend = 0.56), as well as biochemical indices. Our analysis did not reveal any significant associations between the DPI and ABSI (OR: 0.70; 95% CI: 0.35-1.38; Ptrend = 0.30), BRI (OR: 0.80; 95% CI: 0.33-1.95; Ptrend = 0.59), and AVI (OR: 1.99; 95% CI: 0.92-4.33; Ptrend = 0.08).

Conclusions: Our study revealed no significant links between the DPI and foot ulcer indices, neuropathy measures, and anthropometric indices. These findings imply that factors beyond dietary phytochemical intake may exert greater influence on the development of foot ulcers in diabetes.

背景:有关膳食植物化学物摄入量与人体测量指数以及糖尿病足溃疡(DFUs)之间关系的研究仍不一致。我们的目的是调查膳食植物化学物指数(DPI)与新的人体测量指数和糖尿病足溃疡严重程度之间的关系:这项横断面研究的对象是 339 名 2 型糖尿病成人患者。方法:这项横断面研究的对象是 339 名 2 型糖尿病成人患者,通过 3 次 24 小时饮食回顾来评估饮食摄入量。为了量化膳食中的植物化学物质含量,通过麦卡蒂提出的方程对 DPI 进行了估算。国际糖尿病足工作组(IWGDF)标准和瓦格纳分类系统被用于评估 DFU。根据公式计算了新的人体测量指数,包括体形指数(ABSI)、体圆度指数(BRI)和腹部体积指数(AVI)。我们采用方差分析(ANOVA)、协方差分析(ANCOVA)和逻辑回归来探讨 DPI 与人体测量指数和 DFU 变量之间的关系:结果:在对可能的协变量进行调整后,我们发现 DPI 与足部溃疡指数之间没有明显的关联。此外,我们还研究了以单丝评分衡量的糖尿病神经病变与 DPI 之间的关系。同样,我们也没有发现 DPI 和单丝评分(OR:1.18;95% CI:0.66-2.09;Ptrend = 0.56)以及生化指标之间有任何实质性的关系。我们的分析未发现 DPI 与 ABSI(OR:0.70;95% CI:0.35-1.38;Ptrend = 0.30)、BRI(OR:0.80;95% CI:0.33-1.95;Ptrend = 0.59)和 AVI(OR:1.99;95% CI:0.92-4.33;Ptrend = 0.08)之间有任何明显联系:我们的研究表明,DPI 与足部溃疡指数、神经病变指数和人体测量指数之间没有明显联系。这些研究结果表明,膳食植物化学物质摄入量以外的因素可能对糖尿病足溃疡的发生有更大的影响。
{"title":"The relationship between dietary phytochemical index and novel anthropometric indices and the severity of diabetic foot ulcers in adults with type 2 diabetes: a cross-sectional study.","authors":"Moharam Jalalzadeh, Ensieh Nasli-Esfahani, Mohsen Montazer, Faezeh Geravand, Parisa Nezhad Hajian, Mohammad Heidari-Seyedmahalle, Leila Azadbakht","doi":"10.1186/s12902-024-01734-x","DOIUrl":"10.1186/s12902-024-01734-x","url":null,"abstract":"<p><strong>Background: </strong>Research on the relationship between dietary phytochemical intake and the anthropometric indices as well as the diabetic foot ulcers (DFUs) remains inconsistent. We aimed to investigate the associations of dietary phytochemical index (DPI) with the novel anthropometric indices and the severity of DFUs.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 339 adults with type 2 diabetes. Dietary intake was assessed using three 24-hour dietary recalls. To quantify the phytochemical content of the diet, the DPI estimation was done through an equation proposed by McCarty. The International Working Group on the Diabetic Foot (IWGDF) criteria and Wagner classification system were applied to assess DFUs. New anthropometric indices including a body shape index (ABSI), body roundness index (BRI) and abdominal volume index (AVI) were calculated based on formulas. We employed analysis of variance (ANOVA), analysis of covariance (ANCOVA) and logistic regression to explore associations between DPI and the anthropometric indices and DFU variables.</p><p><strong>Results: </strong>Our results revealed no significant association between DPI and the foot ulcer indices, following adjusting for the possible covariates. Furthermore, we also examined the relationship between diabetic neuropathy, as measured by monofilament score, and the DPI. Similarly, we did not find any substantial relationship between the DPI and monofilament score (OR: 1.18; 95% CI: 0.66-2.09; P<sub>trend</sub> = 0.56), as well as biochemical indices. Our analysis did not reveal any significant associations between the DPI and ABSI (OR: 0.70; 95% CI: 0.35-1.38; P<sub>trend</sub> = 0.30), BRI (OR: 0.80; 95% CI: 0.33-1.95; P<sub>trend</sub> = 0.59), and AVI (OR: 1.99; 95% CI: 0.92-4.33; P<sub>trend</sub> = 0.08).</p><p><strong>Conclusions: </strong>Our study revealed no significant links between the DPI and foot ulcer indices, neuropathy measures, and anthropometric indices. These findings imply that factors beyond dietary phytochemical intake may exert greater influence on the development of foot ulcers in diabetes.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a risk model for early diagnosis of metabolic syndrome in Chinese adults aged 40 years and above based on BMI/HDL-C: a cross-sectional study. 基于 BMI/HDL-C 的中国 40 岁及以上成人代谢综合征早期诊断风险模型:一项横断面研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-24 DOI: 10.1186/s12902-024-01752-9
Yu Liu, Xixiang Wang, Jie Mu, Yiyao Gu, Shaobo Zhou, Xiaojun Ma, Jingjing Xu, Lu Liu, Xiuwen Ren, Zhi Duan, Linhong Yuan, Ying Wang

Background: This study aimed to compare the diagnostic accuracy of four indicators, including waist-to-height ratio (WHTR), vascular adiposity index (VAI), TG/HDL-C, and BMI/HDL-C for metabolic syndrome (MS) in Chinese adults aged 40 years and above. Additionally, the study aimed to develop an efficient diagnostic model displayed by a nomogram based on individual's BMI and circulating HDL-C level.

Methods: A cross-sectional study was conducted on 699 participants aged 40 years and above. Quartiles of BMI/HDL-C, TG/HDL-C, VAI, and WHTR were used as independent variables, and metabolic syndrome was used as the dependent variable. Logistic regression was conducted to explore the impact of each parameter on the risk of MS. The areas under the receiver operating characteristics were compared to determine the accuracy of the indicators in diagnosing MS in the participants. Logistic regression was run to construct the nomograms, and the performance of the nomogram was assessed by a calibration curve.

Results: MS subjects had higher levels of BMI, BFM, PBF, VFA, AMC, WC, SCR, TG, and insulin, but lower LDH and HDL-C levels than the subjects without MS. The BMI/HDL-C ratio was positively correlated with the prevalence of MS and its components. The final diagnostic model included five variables: gender, BFM, WC, TG, and BMI/HDL-C. The model showed good calibration and discrimination power with an AUC of 0.780. The cut-off value for the nomogram was 0.623 for diagnosing MS.

Conclusions: BMI/HDL-C ratio was an independent risk factor for MS in Chinese adults. BMI/HDL-C was significantly correlated with MS and its components. BMI/HDL-C was the most powerful diagnostic indicator compared to other indicators, including TG/HDL-C, VAI and WHTR for diagnosing MS. The nomogram drawn based on the diagnostic model provided a practical tool for diagnosing MS in Chinese adults.

研究背景本研究旨在比较腰围身高比(WHTR)、血管脂肪指数(VAI)、总胆固醇/高密度脂蛋白胆固醇(TG/HDL-C)和体重指数/高密度脂蛋白胆固醇(BMI/HDL-C)四项指标对40岁及以上中国成年人代谢综合征(MS)的诊断准确性。此外,该研究还旨在根据个人的体重指数和循环高密度脂蛋白胆固醇(HDL-C)水平,通过提名图建立一个有效的诊断模型:方法:对 699 名 40 岁及以上的参与者进行了横断面研究。将 BMI/HDL-C、TG/HDL-C、VAI 和 WHTR 的四分位数作为自变量,将代谢综合征作为因变量。采用逻辑回归法探讨各参数对 MS 风险的影响。比较接收者操作特征下的面积,以确定这些指标在诊断参与者多发性硬化症方面的准确性。运行逻辑回归构建提名图,并通过校准曲线评估提名图的性能:结果:与非多发性硬化症患者相比,多发性硬化症患者的 BMI、BFM、PBF、VFA、AMC、WC、SCR、TG 和胰岛素水平较高,但 LDH 和 HDL-C 水平较低。体重指数/高密度脂蛋白胆固醇比率与多发性硬化症患病率及其组成部分呈正相关。最终的诊断模型包括五个变量:性别、BFM、WC、TG 和 BMI/HDL-C。该模型显示出良好的校准和辨别能力,AUC 为 0.780。诊断 MS 的提名图临界值为 0.623:结论:BMI/HDL-C 比值是中国成人多发性硬化症的独立危险因素。结论:BMI/HDL-C 是中国成人多发性硬化症的独立危险因素。与 TG/HDL-C、VAI 和 WHTR 等其他诊断 MS 的指标相比,BMI/HDL-C 是最有力的诊断指标。根据诊断模型绘制的提名图为诊断中国成人多发性硬化症提供了实用工具。
{"title":"Developing a risk model for early diagnosis of metabolic syndrome in Chinese adults aged 40 years and above based on BMI/HDL-C: a cross-sectional study.","authors":"Yu Liu, Xixiang Wang, Jie Mu, Yiyao Gu, Shaobo Zhou, Xiaojun Ma, Jingjing Xu, Lu Liu, Xiuwen Ren, Zhi Duan, Linhong Yuan, Ying Wang","doi":"10.1186/s12902-024-01752-9","DOIUrl":"10.1186/s12902-024-01752-9","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the diagnostic accuracy of four indicators, including waist-to-height ratio (WHTR), vascular adiposity index (VAI), TG/HDL-C, and BMI/HDL-C for metabolic syndrome (MS) in Chinese adults aged 40 years and above. Additionally, the study aimed to develop an efficient diagnostic model displayed by a nomogram based on individual's BMI and circulating HDL-C level.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 699 participants aged 40 years and above. Quartiles of BMI/HDL-C, TG/HDL-C, VAI, and WHTR were used as independent variables, and metabolic syndrome was used as the dependent variable. Logistic regression was conducted to explore the impact of each parameter on the risk of MS. The areas under the receiver operating characteristics were compared to determine the accuracy of the indicators in diagnosing MS in the participants. Logistic regression was run to construct the nomograms, and the performance of the nomogram was assessed by a calibration curve.</p><p><strong>Results: </strong>MS subjects had higher levels of BMI, BFM, PBF, VFA, AMC, WC, SCR, TG, and insulin, but lower LDH and HDL-C levels than the subjects without MS. The BMI/HDL-C ratio was positively correlated with the prevalence of MS and its components. The final diagnostic model included five variables: gender, BFM, WC, TG, and BMI/HDL-C. The model showed good calibration and discrimination power with an AUC of 0.780. The cut-off value for the nomogram was 0.623 for diagnosing MS.</p><p><strong>Conclusions: </strong>BMI/HDL-C ratio was an independent risk factor for MS in Chinese adults. BMI/HDL-C was significantly correlated with MS and its components. BMI/HDL-C was the most powerful diagnostic indicator compared to other indicators, including TG/HDL-C, VAI and WHTR for diagnosing MS. The nomogram drawn based on the diagnostic model provided a practical tool for diagnosing MS in Chinese adults.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between the triglyceride-glucose index and vitamin D status: a systematic review and meta-analysis. 甘油三酯-葡萄糖指数与维生素 D 状态之间的关系:系统回顾与荟萃分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-22 DOI: 10.1186/s12902-024-01743-w
Zhitong Li, Shiwei Liu, Xingyu Li, Jinchang Liu, Xin Li, Yuxiang Zhao, Yongliang Feng

Objective: This study aims to explore the association between the triglyceride-glucose (TyG) index and vitamin D status to enhance our understanding of how vitamin D status relates to metabolic health and to provide evidence for the early diagnosis of vitamin D deficiency (VDD) using the TyG index.

Methods: We conducted a comprehensive search in various databases, including PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc, China Science and Technology Journal Database, and Wanfang Data to gather articles published from the inception of these databases until February 19, 2024. We assessed the quality of included studies using the Newcastle-Ottawa Scale (NOS) for case-control studies and the Agency for Healthcare Research and Quality (AHRQ) methodology checklist for cross-sectional studies. Statistical analyses in this study were conducted using conversion methods for non-standard data formats and consolidation techniques for combining multiple groups. The Fisher transformation method was used for correlation coefficients. We used a random-effects model considering the inherent clinical heterogeneity among the studies, and assessed statistical heterogeneity with the Cochrane Q test and I2 statistic, complemented by subgroup analyses and sensitivity analysis.

Results: Our meta-analysis selected a total of nine studies. The analysis revealed that patients with vitamin D deficiency (VDD group) exhibited a significantly higher TyG index than those without deficiency (no-VDD group), with a mean difference (MD) of 0.16 (95% CI: 0.10 to 0.23, I2 = 93%). This association was particularly pronounced among patients with type 2 diabetes (T2DM), showing an MD of 0.15 (95% CI: 0.05 to 0.26, I2 = 55%). Additionally, a negative correlation was observed between the TyG index and vitamin D levels, with a correlation coefficient (r) of -0.236 (95% CI: -0.310 to -0.159, I2 = 91%). Excluding each study sequentially in the sensitivity analyses did not significantly alter the outcomes.

Conclusions: Our findings demonstrate a significant association between the TyG index and vitamin D status across diverse populations, including those with T2DM, subclinical hypothyroidism (SCH), and metabolic associated fatty liver disease (NAFLD). Our results reveal a notable disparity in the TyG index between vitamin D deficient and non-deficient groups, suggesting that vitamin D may play a critical role in metabolic health. These findings highlight the need for further research to explore the underlying mechanisms and clinical implications of vitamin D in the context of various metabolic disorders.

研究目的本研究旨在探讨甘油三酯-葡萄糖(TyG)指数与维生素 D 状态之间的关联,以加深我们对维生素 D 状态与代谢健康关系的理解,并为利用 TyG 指数早期诊断维生素 D 缺乏症(VDD)提供证据:我们在PubMed、Web of Science、Embase、Cochrane Library、中国国家知识基础设施(CNKI)、中国生物医学文献数据库、中国科技期刊数据库和万方数据等多个数据库中进行了全面检索,收集了从这些数据库建立之初到2024年2月19日发表的文章。对于病例对照研究,我们使用纽卡斯尔-渥太华量表(Newcastle-Ottawa Scale,NOS)评估纳入研究的质量;对于横断面研究,我们使用美国医疗保健研究与质量机构(Agency for Healthcare Research and Quality,AHRQ)的方法学检查表评估纳入研究的质量。本研究中的统计分析采用了针对非标准数据格式的转换方法和合并多组数据的合并技术。相关系数采用费雪转换法。考虑到各研究之间固有的临床异质性,我们采用了随机效应模型,并用 Cochrane Q 检验和 I2 统计量评估统计异质性,同时辅以亚组分析和敏感性分析:我们的荟萃分析共选择了九项研究。分析结果显示,维生素 D 缺乏患者(VDD 组)的 TyG 指数明显高于无维生素 D 缺乏患者(无维生素 D 组),平均差(MD)为 0.16(95% CI:0.10 至 0.23,I2 = 93%)。这种关联在 2 型糖尿病 (T2DM) 患者中尤为明显,MD 值为 0.15(95% CI:0.05 至 0.26,I2 = 55%)。此外,TyG指数与维生素D水平之间呈负相关,相关系数(r)为-0.236(95% CI:-0.310 至-0.159,I2 = 91%)。在敏感性分析中依次排除每项研究并没有显著改变结果:我们的研究结果表明,TyG指数与不同人群(包括T2DM、亚临床甲状腺功能减退症(SCH)和代谢相关性脂肪肝(NAFLD)患者)的维生素D状况之间存在明显关联。我们的研究结果表明,缺乏维生素 D 的人群和不缺乏维生素 D 的人群在 TyG 指数上存在明显差异,这表明维生素 D 可能在代谢健康中发挥着关键作用。这些发现强调了进一步研究的必要性,以探索维生素 D 在各种代谢性疾病中的潜在机制和临床意义。
{"title":"The association between the triglyceride-glucose index and vitamin D status: a systematic review and meta-analysis.","authors":"Zhitong Li, Shiwei Liu, Xingyu Li, Jinchang Liu, Xin Li, Yuxiang Zhao, Yongliang Feng","doi":"10.1186/s12902-024-01743-w","DOIUrl":"10.1186/s12902-024-01743-w","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the association between the triglyceride-glucose (TyG) index and vitamin D status to enhance our understanding of how vitamin D status relates to metabolic health and to provide evidence for the early diagnosis of vitamin D deficiency (VDD) using the TyG index.</p><p><strong>Methods: </strong>We conducted a comprehensive search in various databases, including PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc, China Science and Technology Journal Database, and Wanfang Data to gather articles published from the inception of these databases until February 19, 2024. We assessed the quality of included studies using the Newcastle-Ottawa Scale (NOS) for case-control studies and the Agency for Healthcare Research and Quality (AHRQ) methodology checklist for cross-sectional studies. Statistical analyses in this study were conducted using conversion methods for non-standard data formats and consolidation techniques for combining multiple groups. The Fisher transformation method was used for correlation coefficients. We used a random-effects model considering the inherent clinical heterogeneity among the studies, and assessed statistical heterogeneity with the Cochrane Q test and I<sup>2</sup> statistic, complemented by subgroup analyses and sensitivity analysis.</p><p><strong>Results: </strong>Our meta-analysis selected a total of nine studies. The analysis revealed that patients with vitamin D deficiency (VDD group) exhibited a significantly higher TyG index than those without deficiency (no-VDD group), with a mean difference (MD) of 0.16 (95% CI: 0.10 to 0.23, I<sup>2</sup> = 93%). This association was particularly pronounced among patients with type 2 diabetes (T2DM), showing an MD of 0.15 (95% CI: 0.05 to 0.26, I<sup>2</sup> = 55%). Additionally, a negative correlation was observed between the TyG index and vitamin D levels, with a correlation coefficient (r) of -0.236 (95% CI: -0.310 to -0.159, I<sup>2</sup> = 91%). Excluding each study sequentially in the sensitivity analyses did not significantly alter the outcomes.</p><p><strong>Conclusions: </strong>Our findings demonstrate a significant association between the TyG index and vitamin D status across diverse populations, including those with T2DM, subclinical hypothyroidism (SCH), and metabolic associated fatty liver disease (NAFLD). Our results reveal a notable disparity in the TyG index between vitamin D deficient and non-deficient groups, suggesting that vitamin D may play a critical role in metabolic health. These findings highlight the need for further research to explore the underlying mechanisms and clinical implications of vitamin D in the context of various metabolic disorders.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11494808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 diabetes and susceptibility to COVID-19: a machine learning analysis. 2 型糖尿病与 COVID-19 的易感性:机器学习分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-21 DOI: 10.1186/s12902-024-01758-3
Motahare Shabestari, Reyhaneh Azizi, Akram Ghadiri-Anari

Background: Type 2 diabetes mellitus (T2DM) was one of the most prevalent comorbidities among patients with coronavirus disease 2019 (COVID-19). Interactions between different metabolic parameters contribute to the susceptibility to the virus; thereby, this study aimed to rank the importance of clinical and laboratory variables as risk factors for COVID-19 or as protective factors against it by applying machine learning methods.

Method: This study is a retrospective cohort conducted at a single center, focusing on a population with T2DM. The patients attended the Yazd Diabetes Research Center in Yazd, Iran, from February 20, 2020, to October 21, 2020. Clinical and laboratory data were collected within three months before the onset of the COVID-19 pandemic in Iran. 59 patients were infected with COVID-19, while 59 were not. The dataset was split into 70% training and 30% test sets. Principal Component Analysis (PCA) was applied to the data. The most important components were selected using a 'sequential feature selector' and scored by a Linear Discriminant Analysis model. PCA loadings were then multiplied by the PCs' scores to determine the importance of the original variables in contracting COVID-19.

Results: HDL-C, followed by eGFR, showed a strong negative correlation with the risk of contracting the virus. Higher levels of HDL-C and eGFR offer protection against COVID-19 in the T2DM population. But, the ratio of BUN to creatinine did not show any correlation. Conversely, the AIP, TyG index and TG showed the most positive correlation with susceptibility to COVID-19 in such a way that higher levels of these factors increase the risk of contracting the virus. The positive correlation of diastolic BP, TyG-BMI index, MAP, BMI, weight, TC, FPG, HbA1C, Cr, systolic BP, BUN, and LDL-C with the risk of COVID-19 decreased, respectively.

Conclusion: The atherogenic index of plasma, triglyceride glucose index, and triglyceride levels are the most significant risk factors for COVID-19 contracting in individuals with T2DM. Meanwhile, high-density lipoprotein cholesterol is the most protective factor.

背景:2型糖尿病(T2DM)是2019年冠状病毒病(COVID-19)患者最常见的合并症之一。不同代谢参数之间的相互作用导致了对病毒的易感性;因此,本研究旨在通过应用机器学习方法,对作为 COVID-19 风险因素或保护因素的临床和实验室变量的重要性进行排序:本研究是一项在单一中心进行的回顾性队列研究,主要针对 T2DM 患者。患者于 2020 年 2 月 20 日至 2020 年 10 月 21 日在伊朗亚兹德的亚兹德糖尿病研究中心就诊。临床和实验室数据是在伊朗 COVID-19 大流行开始前三个月内收集的。59 名患者感染了 COVID-19,59 名患者未感染。数据集被分成 70% 的训练集和 30% 的测试集。对数据进行了主成分分析(PCA)。使用 "序列特征选择器 "选出最重要的成分,并通过线性判别分析模型进行评分。然后将 PCA 负载乘以 PCs 分数,以确定原始变量在 COVID-19 合同中的重要性:结果:高密度脂蛋白胆固醇(HDL-C)与感染病毒的风险呈强负相关,其次是肾小球滤过率(eGFR)。在 T2DM 群体中,较高水平的 HDL-C 和 eGFR 可防止感染 COVID-19。但是,BUN 与肌酐的比值没有显示出任何相关性。相反,AIP、TyG 指数和 TG 与 COVID-19 的易感性呈现出最大的正相关性,即这些因素的水平越高,感染病毒的风险就越大。舒张压、TyG-BMI 指数、MAP、BMI、体重、TC、FPG、HbA1C、Cr、收缩压、BUN 和 LDL-C 与 COVID-19 风险的正相关性分别下降:结论:血浆致动脉粥样硬化指数、甘油三酯血糖指数和甘油三酯水平是 T2DM 患者感染 COVID-19 的最重要危险因素。同时,高密度脂蛋白胆固醇是最重要的保护因素。
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引用次数: 0
The associations of insulin resistance, obesity, and lifestyle with the risk of developing hyperuricaemia in adolescents. 胰岛素抵抗、肥胖和生活方式与青少年患高尿酸血症风险的关系。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-18 DOI: 10.1186/s12902-024-01757-4
Linyan Cheng, Jinhu Zhou, Ying Zhao, Na Wang, Minya Jin, Wen Mao, Guangjun Zhu, Donglian Wang, Junbo Liang, Bo Shen, Yufen Zheng

Background: Hyperuricaemia is common among obese children and adolescents, and is closely related to insulin resistance. The aim of this study was to explore the relationships between youth insulin resistance and hyperuricaemia, as well as their relationships with lifestyle factors in youths, to provide early guidance on the risk factors for hyperuricaemia in adolescents.

Methods: This study included 233 adolescents aged 10 to 20 years. Insulin resistance was evaluated via the homeostasis model assessment-insulin resistance (HOMA-IR) method. Binary logistic regression analysis was used to assess the associations of HOMA-IR with hyperuricaemia status and serum uric acid (UA) levels. The participants were subsequently divided into two groups, the noninsulin resistant group (HOMA-IR ≤ 3.2) and the insulin resistant group (HOMA-IR > 3.2), to further explore the factors that may affect the serum UA level. Finally, the predictive ability of different indicators of hyperuricaemia was evaluated via the ROC curve.

Results: Binary logistic regression analysis revealed a significant increase in the risk of developing hyperuricaemia for individuals with elevated HOMA-IR (p < 0.001) and insulin resistance (p < 0.01). Spearman's correlation analysis revealed a significant positive linear correlation between HOMA-IR and serum UA levels (r = 0.4652, p < 0.001). Among insulin-resistant adolescents, UA levels were positively correlated with weight ratings, frequency of staying up late, and sugary beverages intake. Notably, individuals who engaged in 1-3 h of weekly exercise had the lowest UA levels. The area under the ROC curve for HOMA-IR was 0.847 (cut-off value = 2.165, p < 0.001), and the optimal prediction model included HOMA-IR, BMI z-score, and other lifestyle factors (AUC: 0.870, p < 0.001)).

Conclusion: HOMA-IR was identified as an independent risk factor for the development of hyperuricaemia and could be used as a sensitive indicator for the prediction its development in adolescents. In insulin-resistant adolescents with hyperuricaemia, maintaining normal weight, engaging in physical exercise for 1-3 h per week, avoiding staying up late and limiting sugary beverages intake are recommended to reduce the prevalence of hyperuricaemia among adolescents.

背景:高尿酸血症是肥胖儿童和青少年的常见病,与胰岛素抵抗密切相关。本研究旨在探讨青少年胰岛素抵抗和高尿酸血症之间的关系,以及它们与青少年生活方式因素之间的关系,为青少年高尿酸血症的风险因素提供早期指导:这项研究包括 233 名 10 至 20 岁的青少年。胰岛素抵抗通过稳态模型评估-胰岛素抵抗(HOMA-IR)法进行评估。二元逻辑回归分析用于评估 HOMA-IR 与高尿酸血症状态和血清尿酸 (UA) 水平之间的关联。随后,参与者被分为两组,即非胰岛素抵抗组(HOMA-IR ≤ 3.2)和胰岛素抵抗组(HOMA-IR > 3.2),以进一步探讨可能影响血清尿酸水平的因素。最后,通过 ROC 曲线评估了不同指标对高尿酸血症的预测能力:二元逻辑回归分析表明,HOMA-IR 升高的人患高尿酸血症的风险显著增加(p 结论:HOMA-IR 是预测高尿酸血症的指标之一:HOMA-IR被认为是高尿酸血症发生的独立风险因素,可作为预测青少年高尿酸血症发生的敏感指标。建议患有高尿酸血症的胰岛素抵抗青少年保持正常体重、每周进行 1-3 小时的体育锻炼、避免熬夜和限制含糖饮料的摄入量,以降低青少年高尿酸血症的发病率。
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引用次数: 0
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