首页 > 最新文献

BMC Endocrine Disorders最新文献

英文 中文
The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007-2012. 2007-2012年美国国家健康调查(NHANES)成人血清可溶性α-Klotho与甲状腺概况之间的关联。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-28 DOI: 10.1186/s12902-024-01687-1
Jing Dong, Min Liu, Guangda Xiang, Ling Yue, Xiaoli Xu, Lin Xiang

Background: Thyroid hormone is the key endocrine regulator of growth, development, metabolism, and other bodily functions. α-Klotho has been involved in the aging process and acts as an endocrine factor involved in the regulation of various metabolic processes in humans. However, the relationship between α-Klotho and thyroid profile has not been uniformly recognize.

Objective: To determine the relationship between α-Klotho and thyroid profile in adult individuals.

Methods: Population data of 4614 adult individuals were obtained from the NHANES database during the period of 2007-2012. Weighted multivariable regression analysis was performed using a general linear model with serum α-Klotho as the independent variable and thyroid profile as the dependent variables, respectively. The generalized additive model was used for smoothing curve fitting and threshold effect analysis.

Results: α-Klotho was associated with a slightly higher FT3, TT3 and TT4 level in unadjusted and adjusted regression models. However, a higher α-Klotho level was associated with a lower TSH level. After α-Klotho was grouped as quantiles with reference (Q1), α-Klotho still showed a statistically significant positive correlation with FT3 and TT3 levels in Q2, Q3 and Q4. In addition, α-Klotho was positively corrected with TT4, but negatively associated with TSH in Q4.

Conclusions: Serum soluble α-Klotho was positively associated with FT3, TT3 and TT4, but negatively correlated with TSH. The significant effect of α-Klotho on thyroid profile suggests its potential as a predictive marker of thyroid functions, indicating its possible involvement in the regulation of thyroid hormone secretion.

背景:甲状腺激素是生长、发育、新陈代谢和其他身体机能的主要内分泌调节因子。α-Klotho参与了人体的衰老过程,并作为一种内分泌因子参与调节人体的各种代谢过程。然而,α-Klotho 与甲状腺概况之间的关系尚未得到统一认识:目的:确定成年个体中α-Klotho与甲状腺概况之间的关系:方法:从NHANES数据库中获取2007-2012年间4614名成人的人口数据。以血清α-Klotho为自变量,甲状腺特征为因变量,采用一般线性模型进行加权多变量回归分析。结果:在未调整和调整回归模型中,α-Klotho 与较高的 FT3、TT3 和 TT4 水平相关。然而,α-Klotho水平越高,TSH水平越低。将α-Klotho与参考值(Q1)进行量化分组后,在Q2、Q3和Q4中,α-Klotho仍与FT3和TT3水平呈统计学意义上的显著正相关。此外,在第四季度,α-Klotho 与 TT4 呈正相关,但与促甲状腺激素呈负相关:结论:血清可溶性α-Klotho与FT3、TT3和TT4呈正相关,但与促甲状腺激素呈负相关。α-Klotho对甲状腺概况的显着影响表明,它有可能成为甲状腺功能的预测性标志物,表明它可能参与了甲状腺激素分泌的调节。
{"title":"The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007-2012.","authors":"Jing Dong, Min Liu, Guangda Xiang, Ling Yue, Xiaoli Xu, Lin Xiang","doi":"10.1186/s12902-024-01687-1","DOIUrl":"10.1186/s12902-024-01687-1","url":null,"abstract":"<p><strong>Background: </strong>Thyroid hormone is the key endocrine regulator of growth, development, metabolism, and other bodily functions. α-Klotho has been involved in the aging process and acts as an endocrine factor involved in the regulation of various metabolic processes in humans. However, the relationship between α-Klotho and thyroid profile has not been uniformly recognize.</p><p><strong>Objective: </strong>To determine the relationship between α-Klotho and thyroid profile in adult individuals.</p><p><strong>Methods: </strong>Population data of 4614 adult individuals were obtained from the NHANES database during the period of 2007-2012. Weighted multivariable regression analysis was performed using a general linear model with serum α-Klotho as the independent variable and thyroid profile as the dependent variables, respectively. The generalized additive model was used for smoothing curve fitting and threshold effect analysis.</p><p><strong>Results: </strong>α-Klotho was associated with a slightly higher FT3, TT3 and TT4 level in unadjusted and adjusted regression models. However, a higher α-Klotho level was associated with a lower TSH level. After α-Klotho was grouped as quantiles with reference (Q1), α-Klotho still showed a statistically significant positive correlation with FT3 and TT3 levels in Q2, Q3 and Q4. In addition, α-Klotho was positively corrected with TT4, but negatively associated with TSH in Q4.</p><p><strong>Conclusions: </strong>Serum soluble α-Klotho was positively associated with FT3, TT3 and TT4, but negatively correlated with TSH. The significant effect of α-Klotho on thyroid profile suggests its potential as a predictive marker of thyroid functions, indicating its possible involvement in the regulation of thyroid hormone secretion.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"161"},"PeriodicalIF":2.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of measuring anthropometric and atherogenic indices in patients with polycystic ovary syndrome. 测量多囊卵巢综合征患者的人体测量和致动脉粥样硬化指数的意义。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-28 DOI: 10.1186/s12902-024-01701-6
Emre Uysal, Omer Tammo, Esra Soylemez, Mehmet Incebıyık, Dilber Filiz, Mesut Alci

Background: Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder affecting 5-15% of women of reproductive age, characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology. PCOS is associated with metabolic disturbances such as dyslipidemia, insulin resistance (IR), and an increased risk of type 2 diabetes (T2DM) and cardiovascular disease.

Objective: The aim of this study is to apply new anthropometric indices [body adiposity index (BAI), visceral adiposity Index (VAI), lipid accumulation product (LAP), body roundness index (BRI), a body shape index (ABSI)] and new atherogenic indices [Castelli index-I, Castelli index-II, atherogenic risk of plasma (AIP), atherogenic coefficient (AC), lipoprotein combined index (LCI), triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio, metabolic score for insulin resistance (METS-IR), triglyceride glucose (TyG) index, triglyceride glucose-dody mass (TyG-BMI) index, triglyceride glucose-waist circumference (TyG-WC) index] metabolic score of insulin resistance to patients with PCOS.

Methods: A retrospective analysis was conducted on 248 women diagnosed with PCOS based on the 2003 Rotterdam criteria. Anthropometric measurements, biochemical parameters, and atherogenic indices were collected from patient records. Statistical analyses were performed using Statistical Package for the Social Sciences software version 28.0.

Results: Significant correlations were found between fasting glucose and various anthropometric indices, such as Body mass index (BMI), waist-height ratio (WHtR), and BAI, indicating a link between adiposity and glucose metabolism in PCOS. Atherogenic indices like Castelli's risk indices, AIP, and AC showed positive correlations with glucose and insulin levels, reinforcing their role in assessing cardiovascular risk. Novel indices such as METS-IR and TyG demonstrated strong correlations with both glucose and insulin profiles, highlighting their potential as reliable markers for IR and cardiometabolic risk.

Conclusion: The study underscores the importance of using a range of anthropometric and atherogenic indices for comprehensive metabolic assessment in women with PCOS. Indices like METS-IR and TyG offer valuable insights into insulin sensitivity and cardiovascular risk, potentially aiding in better management and prognosis of PCOS.

背景:多囊卵巢综合征(PCOS)是一种常见的内分泌疾病,影响着5%-15%的育龄妇女,其特点是排卵功能障碍、高雄激素和多囊卵巢形态。多囊卵巢综合征与代谢紊乱有关,如血脂异常、胰岛素抵抗(IR)以及 2 型糖尿病(T2DM)和心血管疾病的风险增加:本研究旨在应用新的人体测量指数[体脂肪指数(BAI)、内脏脂肪指数(VAI)、脂质累积乘积(LAP)、体圆度指数(BRI)、体形指数(ABSI)]和新的致动脉粥样硬化指数[卡斯泰利指数-I、卡斯泰利指数-II、血浆致动脉粥样硬化风险(AIP)、致动脉粥样硬化系数(AC)、脂蛋白综合指数(LCI)]、胰岛素抵抗的代谢评分(METS-IR)、甘油三酯葡萄糖(TyG)指数、甘油三酯葡萄糖-体重(TyG-BMI)指数、甘油三酯葡萄糖-腰围(TyG-WC)指数]。方法:根据 2003 年鹿特丹标准,对 248 名被诊断为多囊卵巢综合征的女性进行了回顾性分析。从患者记录中收集了人体测量数据、生化参数和致动脉粥样硬化指数。使用 28.0 版社会科学统计软件包进行统计分析:结果:空腹血糖与各种人体测量指数(如体重指数(BMI)、腰高比(WHtR)和 BAI)之间存在显著相关性,表明多囊卵巢综合征患者的脂肪与糖代谢之间存在联系。卡斯泰利风险指数、AIP 和 AC 等致动脉粥样硬化指数与血糖和胰岛素水平呈正相关,加强了它们在评估心血管风险中的作用。METS-IR和TyG等新指数与血糖和胰岛素水平都有很强的相关性,突出了它们作为红外和心血管代谢风险可靠标记物的潜力:这项研究强调了使用一系列人体测量和致动脉粥样硬化指数对多囊卵巢综合征女性进行全面代谢评估的重要性。METS-IR和TyG等指标为了解胰岛素敏感性和心血管风险提供了宝贵的信息,可能有助于改善多囊卵巢综合症的管理和预后。
{"title":"Significance of measuring anthropometric and atherogenic indices in patients with polycystic ovary syndrome.","authors":"Emre Uysal, Omer Tammo, Esra Soylemez, Mehmet Incebıyık, Dilber Filiz, Mesut Alci","doi":"10.1186/s12902-024-01701-6","DOIUrl":"10.1186/s12902-024-01701-6","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder affecting 5-15% of women of reproductive age, characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology. PCOS is associated with metabolic disturbances such as dyslipidemia, insulin resistance (IR), and an increased risk of type 2 diabetes (T2DM) and cardiovascular disease.</p><p><strong>Objective: </strong>The aim of this study is to apply new anthropometric indices [body adiposity index (BAI), visceral adiposity Index (VAI), lipid accumulation product (LAP), body roundness index (BRI), a body shape index (ABSI)] and new atherogenic indices [Castelli index-I, Castelli index-II, atherogenic risk of plasma (AIP), atherogenic coefficient (AC), lipoprotein combined index (LCI), triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio, metabolic score for insulin resistance (METS-IR), triglyceride glucose (TyG) index, triglyceride glucose-dody mass (TyG-BMI) index, triglyceride glucose-waist circumference (TyG-WC) index] metabolic score of insulin resistance to patients with PCOS.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 248 women diagnosed with PCOS based on the 2003 Rotterdam criteria. Anthropometric measurements, biochemical parameters, and atherogenic indices were collected from patient records. Statistical analyses were performed using Statistical Package for the Social Sciences software version 28.0.</p><p><strong>Results: </strong>Significant correlations were found between fasting glucose and various anthropometric indices, such as Body mass index (BMI), waist-height ratio (WHtR), and BAI, indicating a link between adiposity and glucose metabolism in PCOS. Atherogenic indices like Castelli's risk indices, AIP, and AC showed positive correlations with glucose and insulin levels, reinforcing their role in assessing cardiovascular risk. Novel indices such as METS-IR and TyG demonstrated strong correlations with both glucose and insulin profiles, highlighting their potential as reliable markers for IR and cardiometabolic risk.</p><p><strong>Conclusion: </strong>The study underscores the importance of using a range of anthropometric and atherogenic indices for comprehensive metabolic assessment in women with PCOS. Indices like METS-IR and TyG offer valuable insights into insulin sensitivity and cardiovascular risk, potentially aiding in better management and prognosis of PCOS.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"160"},"PeriodicalIF":2.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between mean platelet volume and the risk of type 2 diabetes mellitus among women with history of gestational diabetes mellitus. 有妊娠糖尿病史的妇女的平均血小板体积与罹患 2 型糖尿病风险之间的关系。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-27 DOI: 10.1186/s12902-024-01693-3
Yiling Wei, Yanting Lin, Lili Huang, Caihong Wang, Ruiman Li

Aims: The present study aimed to investigate the relationship between mean platelet volume (MPV) and the risk of type 2 diabetes mellitus (T2DM), among women with and without a history of gestational diabetes mellitus (GDM).

Methods: Eight thousand one hundred eighty-one parous women of the '2007-2018 National Health and Nutrition Examination Survey (NHANES)' were classified into GDM and non-GDM groups based on self-reported GDM history. We investigated the independent association between the MPV and the risk of T2DM in these groups via multivariable regression analysis. A subgroup analysis was done for the GDM group.

Results: After comprehensive adjustment for potential covariates, a significant positive correlation was observed between MPV and the risk of T2DM in women with a history of GDM (OR = 1.50, 95% CI 1.13-2.01, P = 0.006). There was a linear relationship between MPV and T2DM among women with a history of GDM, with each unit increase in MPV increasing the risk of T2DM by 50%. Subgroup analysis and interaction tests revealed a stronger significant effect on women with GDM history who had HbA1c ≥ 7%.

Conclusions: MPV is strongly associated with the incidence of T2DM among U.S. parous women with prior GDM, indicating that MPV may be a potential biomarker of T2DM among women with a history of GDM.

目的:本研究旨在调查有妊娠糖尿病(GDM)病史和无妊娠糖尿病(GDM)病史妇女的平均血小板体积(MPV)与2型糖尿病(T2DM)风险之间的关系:在 "2007-2018 年美国国家健康与营养调查(NHANES)"中,8181 名准妊娠妇女根据自我报告的妊娠糖尿病史被分为妊娠糖尿病组和非妊娠糖尿病组。我们通过多变量回归分析研究了这些组别中 MPV 与 T2DM 风险之间的独立关联。我们还对 GDM 组进行了亚组分析:结果:在对潜在的协变量进行全面调整后,观察到有 GDM 病史的妇女的 MPV 与 T2DM 风险之间存在显著的正相关性(OR = 1.50,95% CI 1.13-2.01,P = 0.006)。在有 GDM 病史的妇女中,MPV 与 T2DM 呈线性关系,MPV 每增加一个单位,T2DM 的风险就增加 50%。亚组分析和交互检验显示,对 HbA1c ≥ 7% 的有 GDM 病史的妇女有更显著的影响:MPV与曾患过GDM的美国准女性中T2DM的发病率密切相关,表明MPV可能是曾患过GDM的女性中T2DM的潜在生物标志物。
{"title":"Association between mean platelet volume and the risk of type 2 diabetes mellitus among women with history of gestational diabetes mellitus.","authors":"Yiling Wei, Yanting Lin, Lili Huang, Caihong Wang, Ruiman Li","doi":"10.1186/s12902-024-01693-3","DOIUrl":"10.1186/s12902-024-01693-3","url":null,"abstract":"<p><strong>Aims: </strong>The present study aimed to investigate the relationship between mean platelet volume (MPV) and the risk of type 2 diabetes mellitus (T2DM), among women with and without a history of gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>Eight thousand one hundred eighty-one parous women of the '2007-2018 National Health and Nutrition Examination Survey (NHANES)' were classified into GDM and non-GDM groups based on self-reported GDM history. We investigated the independent association between the MPV and the risk of T2DM in these groups via multivariable regression analysis. A subgroup analysis was done for the GDM group.</p><p><strong>Results: </strong>After comprehensive adjustment for potential covariates, a significant positive correlation was observed between MPV and the risk of T2DM in women with a history of GDM (OR = 1.50, 95% CI 1.13-2.01, P = 0.006). There was a linear relationship between MPV and T2DM among women with a history of GDM, with each unit increase in MPV increasing the risk of T2DM by 50%. Subgroup analysis and interaction tests revealed a stronger significant effect on women with GDM history who had HbA1c ≥ 7%.</p><p><strong>Conclusions: </strong>MPV is strongly associated with the incidence of T2DM among U.S. parous women with prior GDM, indicating that MPV may be a potential biomarker of T2DM among women with a history of GDM.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"159"},"PeriodicalIF":2.8,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with disease knowledge and attitude among ambulatory patients with type 2 diabetes - a multicenter study. 与2型糖尿病流动患者的疾病知识和态度相关的因素--一项多中心研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-26 DOI: 10.1186/s12902-024-01696-0
Akinniyi A Aje, Titilayo O Fakeye

Background: Diabetes is a multifactorial disease state that requires adequate patient monitoring for improved health outcomes. Diabetes knowledge and attitude, and associated factors such as medication adherence, medication discrepancy, health literacy, and glycemic control were evaluated in this study. The selected factors were also compared with diabetes knowledge and attitude.

Methods: A cross-sectional study was carried out among ambulatory diabetes patients in three tertiary healthcare facilities in Nigeria. An interviewer-administered semi-structured questionnaire was utilized for data collection. Data was analysed using descriptive and inferential statistics with the level of significance set at p < 0.05.

Results: A total of 188 diabetes patients participated in the study; 51 (27.1%) at the Federal Medical Center, Abeokuta, 69 (36.7%) at the University College Hospital, Ibadan, and 68 (36.2%) at the University of Ilorin Teaching Hospital, Ilorin. One hundred and twelve (59.6%) female patients participated in the study and patients' average age was 58.69 ± 13.68 years. Medication discrepancy was observed among 101 (53.7%) patients. One hundred and three (54.8%), 47 (25.0%) and 38 (20.2%) had high, medium, and low medication adherence, respectively. Ninety-one (48.4%) had high health literacy. Mean diabetes knowledge score was 14.64 ± 2.55 points out of a maximum obtainable score of 18 points. Mean diabetes attitude of patients was 62.50 ± 6.86 points out of a maximum obtainable score of 70 points. Significant positive association was observed between diabetes knowledge and health literacy (Beta = 0.021, p = 0.029). Diabetes knowledge was higher in patients with higher level of formal education (p = 0.046), higher diabetes attitude (p < 0.001) and high health literacy (p = 0.002). Patients' diabetes attitude was higher in individuals older than 60 years of age (p = 0.029), and those with high health literacy (p = 0.005).

Conclusions: The diabetes patients displayed good disease knowledge, attitude and medication adherence. Average levels of health literacy and medication discrepancy was observed among the patients. Significant differences were observed between patients' diabetes knowledge and level of formal education, diabetes attitude, health literacy and age. Patients' health literacy was significantly associated with diabetes knowledge.

背景:糖尿病是一种多因素疾病,需要对患者进行充分监测以改善健康状况。本研究评估了糖尿病知识和态度以及相关因素,如用药依从性、用药差异、健康素养和血糖控制。所选因素还与糖尿病知识和态度进行了比较:在尼日利亚三家三级医疗机构的流动糖尿病患者中开展了一项横断面研究。在数据收集过程中使用了由访谈者发放的半结构化问卷。采用描述性和推论性统计方法对数据进行分析,显著性水平设定为 p 结果:共有 188 名糖尿病患者参与了研究,其中阿贝奥库塔联邦医疗中心 51 人(27.1%),伊巴丹大学学院医院 69 人(36.7%),伊洛林大学教学医院 68 人(36.2%)。112名(59.6%)女性患者参与了研究,患者的平均年龄为(58.69 ± 13.68)岁。在 101 名(53.7%)患者中观察到用药不一致现象。用药依从性分别为高、中和低的患者分别有 103 人(54.8%)、47 人(25.0%)和 38 人(20.2%)。91人(48.4%)具有较高的健康素养。糖尿病知识平均得分为 14.64±2.55 分,最高分为 18 分。患者对糖尿病的态度平均为(62.50±6.86)分,最高分为 70 分。糖尿病知识与健康素养之间呈显著正相关(Beta = 0.021,P = 0.029)。正规教育程度较高(p = 0.046)、糖尿病态度较端正(p 结论:糖尿病患者的糖尿病知识水平较高:糖尿病患者在疾病知识、态度和服药依从性方面表现良好。观察到患者的健康知识水平和用药差异处于平均水平。患者的糖尿病知识与正规教育水平、糖尿病态度、健康素养和年龄之间存在显著差异。患者的健康知识水平与糖尿病知识有明显相关性。
{"title":"Factors associated with disease knowledge and attitude among ambulatory patients with type 2 diabetes - a multicenter study.","authors":"Akinniyi A Aje, Titilayo O Fakeye","doi":"10.1186/s12902-024-01696-0","DOIUrl":"10.1186/s12902-024-01696-0","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is a multifactorial disease state that requires adequate patient monitoring for improved health outcomes. Diabetes knowledge and attitude, and associated factors such as medication adherence, medication discrepancy, health literacy, and glycemic control were evaluated in this study. The selected factors were also compared with diabetes knowledge and attitude.</p><p><strong>Methods: </strong>A cross-sectional study was carried out among ambulatory diabetes patients in three tertiary healthcare facilities in Nigeria. An interviewer-administered semi-structured questionnaire was utilized for data collection. Data was analysed using descriptive and inferential statistics with the level of significance set at p < 0.05.</p><p><strong>Results: </strong>A total of 188 diabetes patients participated in the study; 51 (27.1%) at the Federal Medical Center, Abeokuta, 69 (36.7%) at the University College Hospital, Ibadan, and 68 (36.2%) at the University of Ilorin Teaching Hospital, Ilorin. One hundred and twelve (59.6%) female patients participated in the study and patients' average age was 58.69 ± 13.68 years. Medication discrepancy was observed among 101 (53.7%) patients. One hundred and three (54.8%), 47 (25.0%) and 38 (20.2%) had high, medium, and low medication adherence, respectively. Ninety-one (48.4%) had high health literacy. Mean diabetes knowledge score was 14.64 ± 2.55 points out of a maximum obtainable score of 18 points. Mean diabetes attitude of patients was 62.50 ± 6.86 points out of a maximum obtainable score of 70 points. Significant positive association was observed between diabetes knowledge and health literacy (Beta = 0.021, p = 0.029). Diabetes knowledge was higher in patients with higher level of formal education (p = 0.046), higher diabetes attitude (p < 0.001) and high health literacy (p = 0.002). Patients' diabetes attitude was higher in individuals older than 60 years of age (p = 0.029), and those with high health literacy (p = 0.005).</p><p><strong>Conclusions: </strong>The diabetes patients displayed good disease knowledge, attitude and medication adherence. Average levels of health literacy and medication discrepancy was observed among the patients. Significant differences were observed between patients' diabetes knowledge and level of formal education, diabetes attitude, health literacy and age. Patients' health literacy was significantly associated with diabetes knowledge.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"158"},"PeriodicalIF":2.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychometrics properties of type 2 diabetes treatment adherence questionnaire (DTAQ): a study based on Pender's health promotion model. 2 型糖尿病治疗依从性问卷 (DTAQ) 的心理测量学特性:基于彭德健康促进模型的研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-26 DOI: 10.1186/s12902-024-01684-4
Nahid Shahabi, Zahra Hosseini, Teamur Aghamolaei, Amin Ghanbarnejad, Ahmad Behzad

Background: Management of type 2 diabetes (T2D) as a chronic disease requires treatment adherence such as controlling the blood glucose level and adopting a healthy lifestyle. The present study aimed to develop and psychometrically evaluate a questionnaire based on the Pender's Health Promotion Model (HPM) to measure treatment adherence and the associated factors among T2D patients.

Methods: The present study was conducted in qualitative and the quantitative phases between March 2022 and March 2023. The participants were T2D patients visiting Shahid Mohammadi hospital Diabetes Clinic in Bandar Abbas in the south of Iran. The first draft of items was extracted from the qualitative phase. The present study used interviews with T2D patients, item construction, validity and reliability evaluation of the instrument, and the relevant statistical analyses. It emphasized the significance of content, face, and construct validity, along with reliability testing using Cronbach's alpha and test-retest method. Data were analyzed using SPSS software, V16 and AMOS, V23.

Results: A 97-item questionnaire was developed through the qualitative phase and, after content validity, it was reduced to 86 items. Five items were removed in face validation, and after the test-retest method, 79 items were retained. The confirmatory factors analysis confirmed a 65-item model with appropriate fitness of data. Cronbach's alpha coefficient showed an acceptable reliability of the diabetes treatment adherence questionnaire (α = 0.92).

Conclusion: The questionnaire developed based on the HPM model provides a standard and comprehensive measurement of the degree of adherence to treatment and the associated factors among Iranian T2D patients. This is especially valuable in the Iranian healthcare context, where effective management of chronic diseases such as diabetes is of a top priority. Questionnaires can help identify barriers and facilitators of treatment adherence to inform systematic and goal-oriented interventions. The proposed questionnaire had good psychometric properties, and can be used as a valid and practical instrument to measure the factors related to treatment adherence behaviors.

背景:2 型糖尿病(T2D)是一种慢性疾病,需要坚持治疗,如控制血糖水平和采取健康的生活方式。本研究旨在根据彭德健康促进模型(HPM)编制调查问卷,并对其进行心理评估,以衡量 2 型糖尿病患者的治疗依从性及其相关因素:本研究于 2022 年 3 月至 2023 年 3 月期间分定性和定量两个阶段进行。参与者为在伊朗南部阿巴斯港沙希德-穆罕默迪医院糖尿病诊所就诊的 T2D 患者。项目初稿是从定性阶段中提取的。本研究采用了对 T2D 患者的访谈、项目构建、工具的有效性和可靠性评估以及相关的统计分析。研究强调了内容效度、表面效度和结构效度的重要性,并使用 Cronbach's alpha 和重测法进行了可靠性测试。数据使用 SPSS 软件 V16 和 AMOS 软件 V23 进行分析:通过定性阶段编制了 97 个项目的问卷,经过内容效度验证后,问卷减少到 86 个项目。在表面验证中删除了 5 个项目,经过重测法,保留了 79 个项目。确认性因素分析证实了 65 个项目的模型与数据的适当匹配性。Cronbach'sα系数显示糖尿病治疗依从性问卷的信度可以接受(α = 0.92):结论:基于 HPM 模型开发的问卷可对伊朗 T2D 患者的治疗依从性及其相关因素进行标准而全面的测量。在伊朗,有效管理糖尿病等慢性疾病是重中之重。问卷调查有助于确定坚持治疗的障碍和促进因素,为系统性和目标导向的干预措施提供依据。所建议的问卷具有良好的心理测量特性,可作为一种有效而实用的工具来测量与坚持治疗行为相关的因素。
{"title":"Psychometrics properties of type 2 diabetes treatment adherence questionnaire (DTAQ): a study based on Pender's health promotion model.","authors":"Nahid Shahabi, Zahra Hosseini, Teamur Aghamolaei, Amin Ghanbarnejad, Ahmad Behzad","doi":"10.1186/s12902-024-01684-4","DOIUrl":"10.1186/s12902-024-01684-4","url":null,"abstract":"<p><strong>Background: </strong>Management of type 2 diabetes (T2D) as a chronic disease requires treatment adherence such as controlling the blood glucose level and adopting a healthy lifestyle. The present study aimed to develop and psychometrically evaluate a questionnaire based on the Pender's Health Promotion Model (HPM) to measure treatment adherence and the associated factors among T2D patients.</p><p><strong>Methods: </strong>The present study was conducted in qualitative and the quantitative phases between March 2022 and March 2023. The participants were T2D patients visiting Shahid Mohammadi hospital Diabetes Clinic in Bandar Abbas in the south of Iran. The first draft of items was extracted from the qualitative phase. The present study used interviews with T2D patients, item construction, validity and reliability evaluation of the instrument, and the relevant statistical analyses. It emphasized the significance of content, face, and construct validity, along with reliability testing using Cronbach's alpha and test-retest method. Data were analyzed using SPSS software, V16 and AMOS, V23.</p><p><strong>Results: </strong>A 97-item questionnaire was developed through the qualitative phase and, after content validity, it was reduced to 86 items. Five items were removed in face validation, and after the test-retest method, 79 items were retained. The confirmatory factors analysis confirmed a 65-item model with appropriate fitness of data. Cronbach's alpha coefficient showed an acceptable reliability of the diabetes treatment adherence questionnaire (α = 0.92).</p><p><strong>Conclusion: </strong>The questionnaire developed based on the HPM model provides a standard and comprehensive measurement of the degree of adherence to treatment and the associated factors among Iranian T2D patients. This is especially valuable in the Iranian healthcare context, where effective management of chronic diseases such as diabetes is of a top priority. Questionnaires can help identify barriers and facilitators of treatment adherence to inform systematic and goal-oriented interventions. The proposed questionnaire had good psychometric properties, and can be used as a valid and practical instrument to measure the factors related to treatment adherence behaviors.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"157"},"PeriodicalIF":2.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and associated factors of anaemia in patients with type 2 diabetes mellitus: a cross-sectional study in a tertiary care medical unit, Sri Lanka. 斯里兰卡一家三级医疗单位的一项横断面研究:2 型糖尿病患者贫血症的患病率和相关因素。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-23 DOI: 10.1186/s12902-024-01681-7
Sawandika Rupasinghe, Inoka Kumudini Jayasinghe

Background: Anaemia is a global public health issue that impacts individuals of all ages in both developed and developing countries. Anaemia is common in patients with diabetes mellitus; however, it is often undiagnosed and untreated. The main aim of this study was to assess the prevalence and associated factors of anaemia in patients with type 2 diabetes mellitus admitting to a medical unit at National Hospital Kandy.

Methods: A descriptive, cross-sectional study was conducted in type 2 diabetes mellitus (T2DM) patients admitted to a medical ward at National Hospital Kandy (NHK). They were assessed with a pre-tested, interviewer-administered, structured questionnaire using consecutive sampling method. The data was entered and analyzed using SPSS 26.

Results: Total 252 patients with diabetes were included. The prevalence of anaemia in patients with T2DM was 31.3%. The corresponding values for males and females were 34.2% and 65.8% respectively. Independent predictors for anaemia among diabetic patients were older age, female gender, poor glycemic control, diabetes duration > 5 years, diabetic nephropathy, retinopathy, neuropathy, stage ≥ 3 chronic kidney disease (CKD), ischaemic heart disease (IHD), peripheral vascular disease (PVD), diabetic foot ulcers (DFU) and usage of aspirin. These were significantly associated with the prevalence anemia among patients with type 2 diabetes mellitus. Multivariate logistic regression analysis revealed that female gender, age ≥ 65 years, diabetic duration > 5 years, poor glycaemic control, stage ≥ 3 CKD, diabetic nephropathy and retinopathy were associated with greater odds for the presence of anaemia.

Conclusion: We found that 31.3% T2DM patients in a medical ward at NHK had previously undiagnosed anaemia. Anaemia screening during diabetes diagnosis, maintaining glycaemic control and raising patient awareness can reduce anaemia prevalence, improve patient quality of life and potentially reduce microvascular complications.

背景:贫血是一个全球性的公共卫生问题,影响着发达国家和发展中国家各个年龄段的人。贫血在糖尿病患者中很常见,但往往得不到诊断和治疗。本研究的主要目的是评估康提国立医院医疗单位收治的 2 型糖尿病患者中贫血的患病率和相关因素:对康提国立医院(NHK)内科病房收治的2型糖尿病(T2DM)患者进行了一项描述性横断面研究。采用连续抽样的方法,对他们进行了预先测试、由访谈者主持的结构化问卷调查。数据使用 SPSS 26 进行输入和分析:共纳入 252 名糖尿病患者。T2DM 患者的贫血患病率为 31.3%。男性和女性的相应数值分别为 34.2% 和 65.8%。糖尿病患者贫血的独立预测因素包括:年龄较大、女性、血糖控制不佳、糖尿病病程大于 5 年、糖尿病肾病、视网膜病变、神经病变、慢性肾病 (CKD) ≥ 3 期、缺血性心脏病 (IHD)、外周血管疾病 (PVD)、糖尿病足溃疡 (DFU) 和服用阿司匹林。这些因素与 2 型糖尿病患者贫血的发生率有很大关系。多变量逻辑回归分析显示,女性性别、年龄≥65 岁、糖尿病病程大于 5 年、血糖控制不佳、慢性肾脏病≥3 期、糖尿病肾病和视网膜病变与贫血发生的几率较大相关:结论:我们发现,NHK 内科病房中 31.3% 的 T2DM 患者之前未确诊贫血。在糖尿病诊断过程中进行贫血筛查、保持血糖控制和提高患者意识可以降低贫血患病率、改善患者生活质量并减少微血管并发症。
{"title":"Prevalence and associated factors of anaemia in patients with type 2 diabetes mellitus: a cross-sectional study in a tertiary care medical unit, Sri Lanka.","authors":"Sawandika Rupasinghe, Inoka Kumudini Jayasinghe","doi":"10.1186/s12902-024-01681-7","DOIUrl":"10.1186/s12902-024-01681-7","url":null,"abstract":"<p><strong>Background: </strong>Anaemia is a global public health issue that impacts individuals of all ages in both developed and developing countries. Anaemia is common in patients with diabetes mellitus; however, it is often undiagnosed and untreated. The main aim of this study was to assess the prevalence and associated factors of anaemia in patients with type 2 diabetes mellitus admitting to a medical unit at National Hospital Kandy.</p><p><strong>Methods: </strong>A descriptive, cross-sectional study was conducted in type 2 diabetes mellitus (T2DM) patients admitted to a medical ward at National Hospital Kandy (NHK). They were assessed with a pre-tested, interviewer-administered, structured questionnaire using consecutive sampling method. The data was entered and analyzed using SPSS 26.</p><p><strong>Results: </strong>Total 252 patients with diabetes were included. The prevalence of anaemia in patients with T2DM was 31.3%. The corresponding values for males and females were 34.2% and 65.8% respectively. Independent predictors for anaemia among diabetic patients were older age, female gender, poor glycemic control, diabetes duration > 5 years, diabetic nephropathy, retinopathy, neuropathy, stage ≥ 3 chronic kidney disease (CKD), ischaemic heart disease (IHD), peripheral vascular disease (PVD), diabetic foot ulcers (DFU) and usage of aspirin. These were significantly associated with the prevalence anemia among patients with type 2 diabetes mellitus. Multivariate logistic regression analysis revealed that female gender, age ≥ 65 years, diabetic duration > 5 years, poor glycaemic control, stage ≥ 3 CKD, diabetic nephropathy and retinopathy were associated with greater odds for the presence of anaemia.</p><p><strong>Conclusion: </strong>We found that 31.3% T2DM patients in a medical ward at NHK had previously undiagnosed anaemia. Anaemia screening during diabetes diagnosis, maintaining glycaemic control and raising patient awareness can reduce anaemia prevalence, improve patient quality of life and potentially reduce microvascular complications.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"156"},"PeriodicalIF":2.8,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive role of neutrophil-to-lymphocyte ratio in metabolic syndrome: Meta-analysis of 70,937 individuals. 中性粒细胞与淋巴细胞比率在代谢综合征中的预测作用:对 70,937 人进行的元分析。
IF 4.6 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-20 DOI: 10.1186/s12902-024-01689-z
Zhiqiang Qiu, Chahua Huang, Congcong Xu, Yan Xu

Objective: Neutrophil-to-lymphocyte ratio (NLR) has been shown to be an independent predictor for cardiovascular diseases and metabolic diseases. The role of NLR in metabolic syndrome (MS) has also been explored albeit with conflicting results. The objective of this study was to assess the predictive role of NLR in MS.

Methods: We conducted a meta-analysis of observational studies to evaluate the predictive role of NLR in MS. Cochrane library, PubMed, Medline, Embase, and Scopus were systematically searched from their inception to December 2023. The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines was followed. The statistical analysis was performed using RevMan 5.3 software. A randomeffect model was used.

Results: Twenty six studies enrolling 70,937 individuals were included in this meta-analysis. Compared with the individuals without MS, NLR value was significantly higher in the patients of MS (mean difference (MD) 0.40, 95% confidence intervals (CI): 0.27-0.52, P < 0.00001, I2 = 97%). The derived NLR value also was significantly higher in participants with MS than those without MS (MD 0.48, 95%CI: 0.13-0.84, P = 0.007, I2 = 96%). There was no statistically significant association for NLR between the patients with 4 metabolic risk factors (MRF) and those with 3 MRF, or between patients with 5 MRF and those with 4 MRF (MD 0.16, 95%CI: -0.02-0.35, P = 0.10, I2 = 84%; MD 0.12, 95%CI: -0.06-0.29, P = 0.20, I2 = 68%). However, MS patients with 5 MRF had a significantly higher mean NLR value than those with 3MRF (MD 0.37, 95%CI: 0.05-0.68, P = 0.02, I2 = 92%). Compared with the individuals with low NLR, incidence of MS was significantly higher in those with high NLR (OR 2.23, 95%CI: 1.25-3.98, P = 0.006, I2 = 97%).

Conclusion: The findings of our meta-analysis suggested that the value of NLR and derived NLR were higher in MS patients. MS patients with 5 MRF had a significantly higher mean NLR value. High NLR also demonstrated a significantly increased the incidence of MS. NLR may be a good predictive biomarker in MS.

目的中性粒细胞与淋巴细胞比率(NLR)已被证明是心血管疾病和代谢性疾病的独立预测指标。也有人探讨了 NLR 在代谢综合征(MS)中的作用,但结果相互矛盾。本研究旨在评估 NLR 在 MS 中的预测作用:我们对观察性研究进行了荟萃分析,以评估 NLR 在 MS 中的预测作用。我们系统检索了 Cochrane 图书馆、PubMed、Medline、Embase 和 Scopus 中从开始到 2023 年 12 月的所有研究。研究遵循了系统综述和荟萃分析首选报告项目(PRISMA)指南。统计分析使用 RevMan 5.3 软件进行。结果:本次荟萃分析共纳入了 26 项研究,研究对象达 70,937 人。与非多发性硬化症患者相比,多发性硬化症患者的 NLR 值明显更高(平均差(MD)0.40,95% 置信区间(CI):0.27-0.52,P 2 = 97%)。多发性硬化症患者的 NLR 值也明显高于非多发性硬化症患者(MD 0.48,95% 置信区间:0.13-0.84,P = 0.007,I2 = 96%)。有4个代谢风险因素(MRF)的患者与有3个MRF的患者之间,或有5个MRF的患者与有4个MRF的患者之间,NLR均无统计学意义(MD 0.16,95%CI:-0.02-0.35,P = 0.10,I2 = 84%;MD 0.12,95%CI:-0.06-0.29,P = 0.20,I2 = 68%)。然而,有5个MRF的多发性硬化症患者的平均NLR值明显高于有3个MRF的患者(MD 0.37,95%CI:0.05-0.68,P = 0.02,I2 = 92%)。与 NLR 值低的人相比,NLR 值高的人多发性硬化症的发病率明显更高(OR 2.23,95%CI:1.25-3.98,P = 0.006,I2 = 97%):我们的荟萃分析结果表明,多发性硬化症患者的 NLR 和衍生 NLR 值较高。有 5 个 MRF 的多发性硬化症患者的平均 NLR 值明显更高。高 NLR 也表明多发性硬化症的发病率明显增加。NLR可能是预测多发性硬化症的良好生物标志物。
{"title":"Predictive role of neutrophil-to-lymphocyte ratio in metabolic syndrome: Meta-analysis of 70,937 individuals.","authors":"Zhiqiang Qiu, Chahua Huang, Congcong Xu, Yan Xu","doi":"10.1186/s12902-024-01689-z","DOIUrl":"10.1186/s12902-024-01689-z","url":null,"abstract":"<p><strong>Objective: </strong>Neutrophil-to-lymphocyte ratio (NLR) has been shown to be an independent predictor for cardiovascular diseases and metabolic diseases. The role of NLR in metabolic syndrome (MS) has also been explored albeit with conflicting results. The objective of this study was to assess the predictive role of NLR in MS.</p><p><strong>Methods: </strong>We conducted a meta-analysis of observational studies to evaluate the predictive role of NLR in MS. Cochrane library, PubMed, Medline, Embase, and Scopus were systematically searched from their inception to December 2023. The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines was followed. The statistical analysis was performed using RevMan 5.3 software. A randomeffect model was used.</p><p><strong>Results: </strong>Twenty six studies enrolling 70,937 individuals were included in this meta-analysis. Compared with the individuals without MS, NLR value was significantly higher in the patients of MS (mean difference (MD) 0.40, 95% confidence intervals (CI): 0.27-0.52, P < 0.00001, I<sup>2</sup> = 97%). The derived NLR value also was significantly higher in participants with MS than those without MS (MD 0.48, 95%CI: 0.13-0.84, P = 0.007, I<sup>2</sup> = 96%). There was no statistically significant association for NLR between the patients with 4 metabolic risk factors (MRF) and those with 3 MRF, or between patients with 5 MRF and those with 4 MRF (MD 0.16, 95%CI: -0.02-0.35, P = 0.10, I<sup>2</sup> = 84%; MD 0.12, 95%CI: -0.06-0.29, P = 0.20, I<sup>2</sup> = 68%). However, MS patients with 5 MRF had a significantly higher mean NLR value than those with 3MRF (MD 0.37, 95%CI: 0.05-0.68, P = 0.02, I<sup>2</sup> = 92%). Compared with the individuals with low NLR, incidence of MS was significantly higher in those with high NLR (OR 2.23, 95%CI: 1.25-3.98, P = 0.006, I<sup>2</sup> = 97%).</p><p><strong>Conclusion: </strong>The findings of our meta-analysis suggested that the value of NLR and derived NLR were higher in MS patients. MS patients with 5 MRF had a significantly higher mean NLR value. High NLR also demonstrated a significantly increased the incidence of MS. NLR may be a good predictive biomarker in MS.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"155"},"PeriodicalIF":4.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of canagliflozin and teneligliptin on energy intake and body weight in Japanese patients with Type 2 diabetes: a subanalysis of the CANTABILE study. 卡格列净和替尼列汀对日本 2 型糖尿病患者能量摄入和体重的影响比较:CANTABILE 研究的子分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-19 DOI: 10.1186/s12902-024-01690-6
Masahiro Isogawa, Hisashi Makino, Cheol Son, Kunihiro Nishimura, Takumi Hirata, Shu Kasama, Yoshihiro Miyamoto, Michio Noguchi, Masato Kasahara, Kiminori Hosoda

Background: While the Sodium-glucose co-transporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP4) are widely used for the glycemic control in type 2 diabetes mellitus, the differences in the effects of SGLT2 inhibitors and DPP4 inhibitors on energy intake and diabetes-related indicators are unclear.

Methods: This was a subanalysis of the CANTABILE study which compared the effects of canagliflozin and teneligliptin on metabolic factors in Japanese patients with Type 2 diabetes. The changes at 24 weeks from the baseline of the diabetes-related indicators including Hemoglobin A1c (HbA1c), energy intake and body weight were compared between the canagliflozin and teneligliptin groups.

Results: Seventy-five patients in the canagliflozin group and 70 patients in the teneligliptin group were analyzed. A significant decrease in HbA1c was observed in both groups. In the teneligliptin group, although energy intake was significantly reduced, there was no significant change in body weight. Conversely, in the canagliflozin group, although energy intake tended to increase, body weight significantly decreased.

Conclusion: Canagliflozin and teneligliptin have different effects on the dietary status of patients with Type 2 diabetes. Our result suggests that canagliflozin can manage blood glucose without weight gain, even with increased energy intake.

背景:虽然钠-葡萄糖协同转运体2(SGLT2)抑制剂和二肽基肽酶-4(DPP4)被广泛用于2型糖尿病的血糖控制,但SGLT2抑制剂和DPP4抑制剂对能量摄入和糖尿病相关指标的影响差异尚不清楚:本研究是CANTABILE研究的一项子分析,该研究比较了卡格列净和替尼列汀对日本2型糖尿病患者代谢因素的影响。结果比较了卡格列净组和替尼列汀组在24周时糖尿病相关指标(包括血红蛋白A1c (HbA1c)、能量摄入和体重)与基线相比的变化:对 75 名卡格列净组患者和 70 名替尼格列汀组患者进行了分析。两组患者的 HbA1c 均明显下降。在替格列汀组,虽然能量摄入明显减少,但体重却没有明显变化。相反,在卡格列净组,虽然能量摄入呈上升趋势,但体重却明显下降:结论:卡那格列净和替尼列汀对 2 型糖尿病患者的饮食状况有不同的影响。我们的研究结果表明,即使能量摄入增加,卡格列净也能控制血糖而不增加体重。
{"title":"Comparison of canagliflozin and teneligliptin on energy intake and body weight in Japanese patients with Type 2 diabetes: a subanalysis of the CANTABILE study.","authors":"Masahiro Isogawa, Hisashi Makino, Cheol Son, Kunihiro Nishimura, Takumi Hirata, Shu Kasama, Yoshihiro Miyamoto, Michio Noguchi, Masato Kasahara, Kiminori Hosoda","doi":"10.1186/s12902-024-01690-6","DOIUrl":"10.1186/s12902-024-01690-6","url":null,"abstract":"<p><strong>Background: </strong>While the Sodium-glucose co-transporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP4) are widely used for the glycemic control in type 2 diabetes mellitus, the differences in the effects of SGLT2 inhibitors and DPP4 inhibitors on energy intake and diabetes-related indicators are unclear.</p><p><strong>Methods: </strong>This was a subanalysis of the CANTABILE study which compared the effects of canagliflozin and teneligliptin on metabolic factors in Japanese patients with Type 2 diabetes. The changes at 24 weeks from the baseline of the diabetes-related indicators including Hemoglobin A1c (HbA1c), energy intake and body weight were compared between the canagliflozin and teneligliptin groups.</p><p><strong>Results: </strong>Seventy-five patients in the canagliflozin group and 70 patients in the teneligliptin group were analyzed. A significant decrease in HbA1c was observed in both groups. In the teneligliptin group, although energy intake was significantly reduced, there was no significant change in body weight. Conversely, in the canagliflozin group, although energy intake tended to increase, body weight significantly decreased.</p><p><strong>Conclusion: </strong>Canagliflozin and teneligliptin have different effects on the dietary status of patients with Type 2 diabetes. Our result suggests that canagliflozin can manage blood glucose without weight gain, even with increased energy intake.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"153"},"PeriodicalIF":2.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of placental-derived mesenchymal stem cells to restore ovarian function and metabolic profile in a rat model of the polycystic ovarian syndrome. 利用胎盘间充质干细胞恢复多囊卵巢综合征大鼠模型的卵巢功能和代谢状况。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-19 DOI: 10.1186/s12902-024-01688-0
Mojtaba Sarvestani, Alireza Rajabzadeh, Tahereh Mazoochi, Mansooreh Samimi, Mohsen Navari, Faezeh Moradi

Introduction: Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disturbance that affects many women worldwide and is characterized by chronic anovulation, hyperandrogenism, and ovarian dysfunction. Placenta-derived mesenchymal stem cells (PDMSCs) are derived from the placenta and have advantages over other sources of MSCs in terms of availability, safety, and immunomodulation.

Materials and methods: In this experimental study, twenty female Wistar rats were assigned to four groups (n = 5) including control, sham, PCOS, and PCOS+PDMSCs groups. Then, PCOS was induced in the rats through administering letrozole for 21 days. PDMSCs (1 × 106 cells) were injected through the tail vein. Fourteen days after the cell infusion, evaluation was performed on the number of healthy follicles, corpus luteum, and cystic follicles as well as the levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), fasting blood glucose, fasting insulin, and insulin resistance. Moreover, the serum levels of cholesterol, triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured. Liver function was also determined by the evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels.

Results: The number of corpus luteum and primordial, primary, secondary, and antral follicles was significantly elevated in the PCOS+PDMSCs group compared to the PCOS group. However, the number of cystic follicles significantly decreased in the PCOS+PDMSCs group. The LH and testosterone levels also decreased significantly, while FSH levels increased significantly in the PCOS+PDMSCs group. The levels of fasting blood glucose, fasting insulin, and insulin resistance notably decreased in the PCOS+PDMSCs group. Moreover, the lipid profile improved in the PCOS+PDMSCs group along with a significant decrease of cholesterol, LDL, and TG and an increase in HDL. The PCOS+PDMSCs group exhibited marked decreases in the AST and ALT levels as well.

Conclusion: The results of this study suggest that PDMSCs are a potential treatment option for PCOS because they can effectively restore folliculogenesis and correct hormonal imbalances, lipid profiles and liver dysfunction in a rat model of PCOS. However, further research is needed to establish the safety and effectiveness of PDMSCs for treating PCOS.

导言多囊卵巢综合征(PCOS)是一种内分泌和代谢紊乱疾病,影响着全球许多妇女,其特征是慢性无排卵、高雄激素和卵巢功能障碍。胎盘间充质干细胞(PDMSCs)来源于胎盘,与其他来源的间充质干细胞相比,它在可用性、安全性和免疫调节方面具有优势:在这项实验研究中,20 只雌性 Wistar 大鼠被分为四组(n = 5),包括对照组、假阳性组、PCOS 组和 PCOS+PDMSCs 组。然后,通过给大鼠注射来曲唑诱导 PCOS,为期 21 天。通过尾静脉注射 PDMSCs(1 × 106 个细胞)。细胞注射 14 天后,对健康卵泡、黄体和囊性卵泡的数量以及睾酮、卵泡刺激素(FSH)、黄体生成素(LH)、空腹血糖、空腹胰岛素和胰岛素抵抗的水平进行评估。此外,还测量了血清中胆固醇、甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)的水平。此外,还通过评估天冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)水平来确定肝功能:结果:与多囊卵巢综合征组相比,多囊卵巢综合征+PDMSCs组的黄体、原始卵泡、初级卵泡、次级卵泡和前卵泡数量明显增加。然而,PCOS+PDMSCs 组的囊性卵泡数量明显减少。PCOS+PDMSCs组的LH和睾酮水平也明显下降,而FSH水平则明显上升。PCOS+PDMSCs 组的空腹血糖、空腹胰岛素和胰岛素抵抗水平明显下降。此外,PCOS+PDMSCs 组的血脂状况也有所改善,胆固醇、低密度脂蛋白和总胆固醇显著下降,高密度脂蛋白增加。PCOS+PDMSCs 组的 AST 和 ALT 水平也明显下降:本研究的结果表明,PDMSCs 是治疗多囊卵巢综合征的一种潜在方法,因为它能有效恢复多囊卵巢综合征大鼠模型的卵泡生成,纠正激素失衡、血脂异常和肝功能异常。然而,还需要进一步的研究来确定 PDMSCs 治疗多囊卵巢综合症的安全性和有效性。
{"title":"Use of placental-derived mesenchymal stem cells to restore ovarian function and metabolic profile in a rat model of the polycystic ovarian syndrome.","authors":"Mojtaba Sarvestani, Alireza Rajabzadeh, Tahereh Mazoochi, Mansooreh Samimi, Mohsen Navari, Faezeh Moradi","doi":"10.1186/s12902-024-01688-0","DOIUrl":"10.1186/s12902-024-01688-0","url":null,"abstract":"<p><strong>Introduction: </strong>Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disturbance that affects many women worldwide and is characterized by chronic anovulation, hyperandrogenism, and ovarian dysfunction. Placenta-derived mesenchymal stem cells (PDMSCs) are derived from the placenta and have advantages over other sources of MSCs in terms of availability, safety, and immunomodulation.</p><p><strong>Materials and methods: </strong>In this experimental study, twenty female Wistar rats were assigned to four groups (n = 5) including control, sham, PCOS, and PCOS+PDMSCs groups. Then, PCOS was induced in the rats through administering letrozole for 21 days. PDMSCs (1 × 10<sup>6</sup> cells) were injected through the tail vein. Fourteen days after the cell infusion, evaluation was performed on the number of healthy follicles, corpus luteum, and cystic follicles as well as the levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), fasting blood glucose, fasting insulin, and insulin resistance. Moreover, the serum levels of cholesterol, triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured. Liver function was also determined by the evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels.</p><p><strong>Results: </strong>The number of corpus luteum and primordial, primary, secondary, and antral follicles was significantly elevated in the PCOS+PDMSCs group compared to the PCOS group. However, the number of cystic follicles significantly decreased in the PCOS+PDMSCs group. The LH and testosterone levels also decreased significantly, while FSH levels increased significantly in the PCOS+PDMSCs group. The levels of fasting blood glucose, fasting insulin, and insulin resistance notably decreased in the PCOS+PDMSCs group. Moreover, the lipid profile improved in the PCOS+PDMSCs group along with a significant decrease of cholesterol, LDL, and TG and an increase in HDL. The PCOS+PDMSCs group exhibited marked decreases in the AST and ALT levels as well.</p><p><strong>Conclusion: </strong>The results of this study suggest that PDMSCs are a potential treatment option for PCOS because they can effectively restore folliculogenesis and correct hormonal imbalances, lipid profiles and liver dysfunction in a rat model of PCOS. However, further research is needed to establish the safety and effectiveness of PDMSCs for treating PCOS.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"154"},"PeriodicalIF":2.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Helicobacter pylori infection with complications of diabetes: a single-center retrospective study. 幽门螺杆菌感染与糖尿病并发症的关系:一项单中心回顾性研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-14 DOI: 10.1186/s12902-024-01678-2
Zhuoya Li, Jie Zhang, Yizhou Jiang, Kai Ma, Cheng Cui, Xiaoyong Wang

Background: Previous studies examined the association of Helicobacter pylori infection (H. pylori) with complications of diabetes, but the results have been inconsistent. The aim of this study of patients with type-2 diabetes (T2D) was to determine the association of H. pylori infection with the major complications of diabetes.

Methods: This single-center retrospective study examined patients with T2D who received H. pylori testing between January 2016 and December 2021. Logistic regression analyses were used to evaluate the association of H. pylori infection with four major complications of diabetes.

Results: We examined 960 patients with T2D, and 481 of them (50.1%) were positive for H. pylori. H. pylori infection was significantly associated with diabetic nephropathy (odds ratio [OR] = 1.462; 95% confidence interval [CI]: 1.006,2.126; P = 0.046). In addition, the co-occurrence of H. pylori positivity with hypertension (OR = 4.451; 95% CI: 2.351,8.427; P < 0.001), with glycated hemoglobin A1c (HbA1c) of at least 8% (OR = 2.925; 95% CI: 1.544,5.541; P = 0.001), and with diabetes duration of at least 9 years (OR = 3.305; 95% CI:1.823,5.993; P < 0.001) further increased the risk of diabetic nephropathy. There was no evidence of an association of H. pylori infection with retinopathy, neuropathy, or peripheral vascular disease.

Conclusions: Our study of T2D patients indicated that those with H. pylori infections had an increased risk of nephropathy, and this risk was greater in patients who also had hypertension, an HbA1c level of 8% or more, and diabetes duration of 9 years or more.

背景:以往的研究探讨了幽门螺杆菌感染与糖尿病并发症的关系,但结果并不一致。这项针对 2 型糖尿病(T2D)患者的研究旨在确定幽门螺杆菌感染与糖尿病主要并发症的关系:这项单中心回顾性研究调查了2016年1月至2021年12月期间接受幽门螺杆菌检测的T2D患者。采用逻辑回归分析评估幽门螺杆菌感染与糖尿病四种主要并发症的关系:我们对960名T2D患者进行了检查,其中481人(50.1%)幽门螺杆菌检测呈阳性。幽门螺杆菌感染与糖尿病肾病显著相关(几率比 [OR] = 1.462;95% 置信区间 [CI]:1.006,2.12%):1.006,2.126; P = 0.046).此外,幽门螺杆菌阳性与高血压同时存在(OR = 4.451;95% CI:2.351,8.427;P 结论:幽门螺杆菌阳性与高血压同时存在的可能性很高:我们对 T2D 患者的研究表明,幽门螺杆菌感染者发生肾病的风险增加,而同时患有高血压、HbA1c 水平达到或超过 8%、糖尿病病程达到或超过 9 年的患者发生肾病的风险更大。
{"title":"Association of Helicobacter pylori infection with complications of diabetes: a single-center retrospective study.","authors":"Zhuoya Li, Jie Zhang, Yizhou Jiang, Kai Ma, Cheng Cui, Xiaoyong Wang","doi":"10.1186/s12902-024-01678-2","DOIUrl":"10.1186/s12902-024-01678-2","url":null,"abstract":"<p><strong>Background: </strong>Previous studies examined the association of Helicobacter pylori infection (H. pylori) with complications of diabetes, but the results have been inconsistent. The aim of this study of patients with type-2 diabetes (T2D) was to determine the association of H. pylori infection with the major complications of diabetes.</p><p><strong>Methods: </strong>This single-center retrospective study examined patients with T2D who received H. pylori testing between January 2016 and December 2021. Logistic regression analyses were used to evaluate the association of H. pylori infection with four major complications of diabetes.</p><p><strong>Results: </strong>We examined 960 patients with T2D, and 481 of them (50.1%) were positive for H. pylori. H. pylori infection was significantly associated with diabetic nephropathy (odds ratio [OR] = 1.462; 95% confidence interval [CI]: 1.006,2.126; P = 0.046). In addition, the co-occurrence of H. pylori positivity with hypertension (OR = 4.451; 95% CI: 2.351,8.427; P < 0.001), with glycated hemoglobin A1c (HbA1c) of at least 8% (OR = 2.925; 95% CI: 1.544,5.541; P = 0.001), and with diabetes duration of at least 9 years (OR = 3.305; 95% CI:1.823,5.993; P < 0.001) further increased the risk of diabetic nephropathy. There was no evidence of an association of H. pylori infection with retinopathy, neuropathy, or peripheral vascular disease.</p><p><strong>Conclusions: </strong>Our study of T2D patients indicated that those with H. pylori infections had an increased risk of nephropathy, and this risk was greater in patients who also had hypertension, an HbA1c level of 8% or more, and diabetes duration of 9 years or more.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"152"},"PeriodicalIF":2.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
BMC Endocrine Disorders
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1