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Development and validation of a nomogram for screening patients with type 2 diabetic ketoacidosis 开发并验证用于筛查 2 型糖尿病酮症酸中毒患者的提名图
IF 2.7 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-12 DOI: 10.1186/s12902-024-01677-3
Hui Li, Bo Su, Gui Zhong Li
The early detection of diabetic ketoacidosis (DKA) in patients with type 2 diabetes (T2D) plays a crucial role in enhancing outcomes. We developed a nomogram prediction model for screening DKA in T2D patients. At the same time, the input variables were adjusted to reduce misdiagnosis. We obtained data on T2D patients from Mimic-IV V0.4 and Mimic-III V1.4 databases. A nomogram model was developed using the training data set, internally validated, subjected to sensitivity analysis, and further externally validated with data from T2D patients in Aviation General Hospital. Based on the established model, we analyzed 1885 type 2 diabetes patients, among whom 614 with DKA. We further additionally identified risk factors for DKA based on literature reports and multivariate analysis. We identified age, glucose, chloride, calcium, and urea nitrogen as predictors in our model. The logistic regression model demonstrated an area under the curve (AUC) of 0.86 (95%CI: 0.85–0.90]. To validate the model, we collected data from 91 T2D patients, including 15 with DKA, at our hospital. The external validation of the model yielded an AUC of 0.68 (95%CI: 0.67–0.70). The calibration plot confirmed that our model was adequate for predicting patients with DKA. The decision-curve analysis revealed that our model offered net benefits for clinical use. Our model offers a convenient and accurate tool for predicting whether DKA is present. Excluding input variables that may potentially hinder patient compliance increases the practical application significance of our model.
早期发现 2 型糖尿病(T2D)患者的糖尿病酮症酸中毒(DKA)对改善预后起着至关重要的作用。我们开发了一个用于筛查 T2D 患者 DKA 的提名图预测模型。同时,对输入变量进行了调整,以减少误诊。我们从 Mimic-IV V0.4 和 Mimic-III V1.4 数据库中获得了 T2D 患者的数据。我们利用训练数据集建立了一个提名图模型,进行了内部验证和敏感性分析,并利用航空总医院的 T2D 患者数据进一步进行了外部验证。根据建立的模型,我们分析了 1885 名 2 型糖尿病患者,其中 614 人患有 DKA。根据文献报道和多变量分析,我们进一步确定了 DKA 的风险因素。我们确定年龄、血糖、氯化物、钙和尿素氮为模型中的预测因素。逻辑回归模型的曲线下面积(AUC)为 0.86(95%CI:0.85-0.90]。为了验证该模型,我们收集了本医院 91 名 T2D 患者的数据,其中包括 15 名 DKA 患者。模型外部验证的 AUC 为 0.68(95%CI:0.67-0.70)。校准图证实我们的模型足以预测 DKA 患者。决策曲线分析表明,我们的模型为临床应用提供了净效益。我们的模型为预测是否存在 DKA 提供了一个方便、准确的工具。排除可能妨碍患者依从性的输入变量,提高了我们模型的实际应用意义。
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引用次数: 0
Lipid accumulation product and type 2 diabetes risk: a population-based study 脂质累积产物与 2 型糖尿病风险:一项基于人群的研究
IF 2.7 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-12 DOI: 10.1186/s12902-024-01682-6
Sepehr Sadafi, Ali Azizi, Farid Najafi, Yahya Pasdar
The Lipid Accumulation Product (LAP) is a measure that indicates excessive fat accumulation in the body. LAP has been the focus of research in epidemiological studies aimed at forecasting chronic and metabolic diseases. This study aimed to evaluate the association between LAP and type 2 diabetes mellitus (T2DM) among adults in western Iran. The study involved 9,065 adults who participated in the initial phase of the Ravansar non-communicable diseases study (RaNCD) cohort. To investigate the association between LAP and T2DM, multiple logistic regressions were employed. Additionally, the receiver operating characteristic (ROC) curve was used to evaluate LAP’s predictive ability concerning T2DM. The participants had an average age of 47.24 ± 8.27 years, comprising 49.30% men and 50.70% women. The mean LAP was 53.10 ± 36.60 for the healthy group and 75.51 ± 51.34 for the diabetic group (P < 0.001). The multiple regression analysis revealed that the odds of T2DM in the second quartile of LAP were 1.69 (95% CI: 1.25, 2.29) times greater than in the first quartile. Furthermore, the odds in the third and fourth quartiles were 2.67 (95% CI: 2.01, 3.55) and 3.73 (95% CI: 2.83, 4.92) times higher, respectively. The ROC analysis for predicting T2DM showed that the LAP index had an area under the curve (AUC) of 0.66 (95% CI: 0.64, 0.68). A strong association was identified between elevated LAP levels and T2DM in the adult population of western Iran. LAP is recommended as a potential tool for screening diabetes susceptibility.
脂质堆积产物(LAP)是一种表明体内脂肪过度堆积的指标。LAP 一直是流行病学研究的重点,旨在预测慢性和代谢性疾病。本研究旨在评估 LAP 与伊朗西部成人 2 型糖尿病(T2DM)之间的关联。这项研究涉及 9,065 名成人,他们都参加了 Ravansar 非传染性疾病研究(RaNCD)队列的初始阶段。为了研究 LAP 与 T2DM 之间的关系,研究人员采用了多重逻辑回归。此外,还使用接收者操作特征曲线(ROC)来评估 LAP 对 T2DM 的预测能力。参与者的平均年龄为(47.24 ± 8.27)岁,其中男性占 49.30%,女性占 50.70%。健康组的平均 LAP 为 53.10 ± 36.60,糖尿病组为 75.51 ± 51.34(P < 0.001)。多元回归分析显示,LAP 在第二四分位数的 T2DM 发生几率是第一四分位数的 1.69 倍(95% CI:1.25,2.29)。此外,第三和第四四分位数的几率分别是第一四分位数的 2.67 倍(95% CI:2.01,3.55)和 3.73 倍(95% CI:2.83,4.92)。预测 T2DM 的 ROC 分析显示,LAP 指数的曲线下面积 (AUC) 为 0.66(95% CI:0.64,0.68)。在伊朗西部的成年人群中,LAP 水平升高与 T2DM 之间存在密切联系。建议将 LAP 作为筛查糖尿病易感性的潜在工具。
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引用次数: 0
Incomplete ablation of thyroid cancer: Achilles' Heel? 甲状腺癌的不完全消融:致命弱点?
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-09 DOI: 10.1186/s12902-024-01659-5
Ze Yang, Xue-Hua Pan, Heng-Tong Han, Yong-Xun Zhao, Li-Bin Ma

Background: In recent years, the incidence of thyroid nodules has increased significantly. There are various ways to treat thyroid nodules, and ablation therapy is one of the important ways to treat thyroid nodules. However, there are many complications and deficiencies in the current ablation treatment of thyroid nodules, especially the incomplete ablation of thyroid cancer nodules, which limits the further application of ablation technology. In this paper, we report two cases of incomplete ablation of thyroid nodules, one of which underwent surgical treatment due to anxiety after ablation, and the postoperative pathology confirmed that there was still residual papillary thyroid carcinoma, and the other patient underwent an operation after ablation, but visited our medical institution again due to cervical lymph node metastasis in a short period of time, and after radical cervical lymph node dissection, pathology confirmed multiple cervical lymph node metastasis. Radionuclide therapy was performed after surgery, and two patients are currently receiving endocrine suppression therapy, and their condition is stable with no signs of recurrence.

Conclusion: The incomplete ablation of thyroid cancer nodules limits the development of ablation therapy, making ablation treatment a double-edged sword. Guidelines and expert consensus can guide their development, but they need to evolve with the times, and a multidisciplinary diagnostic team can help screen the most suitable patients. Only by using this technology more standardly, using the most appropriate technology, and treating the most suitable patients, can benefit more and more patients.

背景:近年来,甲状腺结节的发病率明显上升。治疗甲状腺结节的方法多种多样,消融治疗是治疗甲状腺结节的重要方法之一。但目前消融治疗甲状腺结节存在很多并发症和不足,尤其是甲状腺癌结节消融不彻底,限制了消融技术的进一步应用。本文报告了两例甲状腺结节不完全消融病例,其中一例患者消融后因焦虑接受手术治疗,术后病理证实仍有甲状腺乳头状癌残留;另一例患者消融后接受手术治疗,但短时间内因颈淋巴结转移再次就诊,行根治性颈淋巴结清扫术后,病理证实多发颈淋巴结转移。术后进行了放射性核素治疗,目前两名患者正在接受内分泌抑制治疗,病情稳定,无复发迹象:结论:甲状腺癌结节的不完全消融限制了消融治疗的发展,使消融治疗成为一把双刃剑。指南和专家共识可以指导其发展,但也需要与时俱进,多学科诊断团队可以帮助筛选出最合适的患者。只有更规范地使用这项技术,使用最合适的技术,治疗最合适的患者,才能让越来越多的患者受益。
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引用次数: 0
Association between COVID-19 and the incidence of type 1 diabetes in Portugal - a registry study. 葡萄牙 COVID-19 与 1 型糖尿病发病率之间的关系--一项登记研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-09 DOI: 10.1186/s12902-024-01667-5
Morten Bjerregaard-Andersen, Jessica Da Silva, Rui Diogo, Ana Raquel Claro, Inês Ferro, Andreia Romana, Patrícia Rocha, Beatriz Sá, Goreti Lobarinhas, Sara Rolim, Claus Bogh Juhl, Kurt Højlund, Isabel Fernandes, Sónia Antunes, Maria Manuela Félix Calha, Guida Gama, Sofia Amálio, Mariana Figueiras, Teresa Silva, Margarida Rosado, Estela Ferrão, Luísa Arez, Ana Baptista, Adriana Martins Ferreira, Diana Alba, Carlos Godinho, Ana Luísa Leite, Maria de Lurdes Afonso Lopes, Maria Lurdes Sampaio, Joana Serra-Caetano, Eugenia Carvalho

Background: Viral respiratory infections may precipitate type 1 diabetes (T1D). A possible association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, and the incidence of T1D is being determined. This study was carried out using Portuguese registries, aiming at examining temporal trends between COVID-19 and T1D.

Methods: Hospital data, comparing the incidence before and during the COVID-19 pandemic, from children and young adults diagnosed with new-onset T1D, was acquired beginning in 2017 and until the end of 2022. Data was obtained from nine different Portuguese hospital units. The impact of the COVID-19 pandemic, beginning in March 2020, was assessed comparing the annual numbers of new-onset T1D cases. The annual median levels of glucose, glycated hemoglobin (HbA1c) and fasting C-peptide at T1D diagnosis were compared. The annual number of diabetic ketoacidosis (DKA) episodes among new T1D cases was also assessed at two centers.

Results: In total, data from 574 newly diagnosed T1D patients was analyzed, including 530 (92.3%) children. The mean ages for child and adult patients were 9.1 (SD 4.4) and 32.8 (SD 13.6) years, respectively. 57.8% (331/573) were male, one patient had unknown sex. The overall median (25-75 percentiles) levels of glucose, HbA1c and fasting C-peptide at diagnosis were 454 mg/dL (356-568), 11.8% (10.1-13.4) and 0.50 µg/L (0.30-0.79), respectively. DKA at T1D diagnosis was present in 48.4% (76/157). For eight centers with complete 2018 to 2021 data (all calendar months), no overall significant increase in T1D cases was observed during the COVID-19 pandemic, i.e. 90 cases in 2018, 90 cases in 2019, 112 in 2020 and 100 in 2021 (P for trend = 0.36). Two of the centers, Faro (CHUA) and Dona Estefânia (CHULC) hospitals, did however see an increase in T1D from 2019 to 2020. No significant changes in glucose (P = 0.32), HbA1c (P = 0.68), fasting C-peptide (P = 0.20) or DKA frequency (P = 0.68) at the time of T1D diagnosis were observed over the entire study period.

Conclusion: The T1D incidence did not increase significantly, when comparing the years before and during the COVID-19 pandemic, nor did key metabolic parameters or number of DKA episodes change.

背景:病毒性呼吸道感染可能诱发 1 型糖尿病(T1D):病毒性呼吸道感染可能会诱发 1 型糖尿病(T1D)。目前正在确定严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)(COVID-19 的致病病毒)与 T1D 发病率之间可能存在的联系。方法:从 2017 年开始到 2022 年底,从被诊断为新发 T1D 的儿童和年轻成人中获取医院数据,比较 COVID-19 大流行之前和期间的发病率。数据来自葡萄牙九家不同的医院单位。通过比较每年新发 T1D 病例的数量,评估了 COVID-19 大流行(2020 年 3 月开始)的影响。比较了确诊 T1D 时的血糖、糖化血红蛋白 (HbA1c) 和空腹 C 肽的年度中位数水平。此外,还评估了两个中心的 T1D 新发病例中每年发生糖尿病酮症酸中毒(DKA)的次数:结果:共分析了 574 名新确诊 T1D 患者的数据,其中包括 530 名儿童(92.3%)。儿童和成人患者的平均年龄分别为 9.1 岁(标清 4.4 岁)和 32.8 岁(标清 13.6 岁)。57.8%(331/573)为男性,一名患者性别未知。确诊时血糖、HbA1c 和空腹 C 肽的总体中位数(25-75 百分位数)分别为 454 mg/dL (356-568)、11.8% (10.1-13.4) 和 0.50 µg/L (0.30-0.79)。48.4%(76/157)的患者在诊断 T1D 时出现 DKA。在拥有 2018 年至 2021 年完整数据(所有日历月)的八个中心中,在 COVID-19 大流行期间未观察到 T1D 病例的总体显著增加,即 2018 年 90 例、2019 年 90 例、2020 年 112 例和 2021 年 100 例(趋势 P = 0.36)。不过,其中两个中心,即法鲁(CHUA)医院和埃斯特法尼亚修女医院(CHULC),从2019年到2020年T1D病例确实有所增加。在整个研究期间,T1D诊断时的血糖(P = 0.32)、HbA1c(P = 0.68)、空腹C肽(P = 0.20)或DKA频率(P = 0.68)均未出现明显变化:结论:与 COVID-19 大流行之前和期间相比,T1D 发病率没有显著增加,主要代谢参数或 DKA 发作次数也没有变化。
{"title":"Association between COVID-19 and the incidence of type 1 diabetes in Portugal - a registry study.","authors":"Morten Bjerregaard-Andersen, Jessica Da Silva, Rui Diogo, Ana Raquel Claro, Inês Ferro, Andreia Romana, Patrícia Rocha, Beatriz Sá, Goreti Lobarinhas, Sara Rolim, Claus Bogh Juhl, Kurt Højlund, Isabel Fernandes, Sónia Antunes, Maria Manuela Félix Calha, Guida Gama, Sofia Amálio, Mariana Figueiras, Teresa Silva, Margarida Rosado, Estela Ferrão, Luísa Arez, Ana Baptista, Adriana Martins Ferreira, Diana Alba, Carlos Godinho, Ana Luísa Leite, Maria de Lurdes Afonso Lopes, Maria Lurdes Sampaio, Joana Serra-Caetano, Eugenia Carvalho","doi":"10.1186/s12902-024-01667-5","DOIUrl":"10.1186/s12902-024-01667-5","url":null,"abstract":"<p><strong>Background: </strong>Viral respiratory infections may precipitate type 1 diabetes (T1D). A possible association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, and the incidence of T1D is being determined. This study was carried out using Portuguese registries, aiming at examining temporal trends between COVID-19 and T1D.</p><p><strong>Methods: </strong>Hospital data, comparing the incidence before and during the COVID-19 pandemic, from children and young adults diagnosed with new-onset T1D, was acquired beginning in 2017 and until the end of 2022. Data was obtained from nine different Portuguese hospital units. The impact of the COVID-19 pandemic, beginning in March 2020, was assessed comparing the annual numbers of new-onset T1D cases. The annual median levels of glucose, glycated hemoglobin (HbA1c) and fasting C-peptide at T1D diagnosis were compared. The annual number of diabetic ketoacidosis (DKA) episodes among new T1D cases was also assessed at two centers.</p><p><strong>Results: </strong>In total, data from 574 newly diagnosed T1D patients was analyzed, including 530 (92.3%) children. The mean ages for child and adult patients were 9.1 (SD 4.4) and 32.8 (SD 13.6) years, respectively. 57.8% (331/573) were male, one patient had unknown sex. The overall median (25-75 percentiles) levels of glucose, HbA1c and fasting C-peptide at diagnosis were 454 mg/dL (356-568), 11.8% (10.1-13.4) and 0.50 µg/L (0.30-0.79), respectively. DKA at T1D diagnosis was present in 48.4% (76/157). For eight centers with complete 2018 to 2021 data (all calendar months), no overall significant increase in T1D cases was observed during the COVID-19 pandemic, i.e. 90 cases in 2018, 90 cases in 2019, 112 in 2020 and 100 in 2021 (P for trend = 0.36). Two of the centers, Faro (CHUA) and Dona Estefânia (CHULC) hospitals, did however see an increase in T1D from 2019 to 2020. No significant changes in glucose (P = 0.32), HbA1c (P = 0.68), fasting C-peptide (P = 0.20) or DKA frequency (P = 0.68) at the time of T1D diagnosis were observed over the entire study period.</p><p><strong>Conclusion: </strong>The T1D incidence did not increase significantly, when comparing the years before and during the COVID-19 pandemic, nor did key metabolic parameters or number of DKA episodes change.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum ferritin level and associated factors among uncontrolled adult type II diabetic follow-up patients: comparative based cross-sectional study. 未受控制的成年 II 型糖尿病随访患者的血清铁蛋白水平及相关因素:基于比较的横断面研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-07 DOI: 10.1186/s12902-024-01665-7
Andualem Bayih, Gobena Dedefo, Samuel Kinde, Mekdes Alem, Abebe Edao Negesso, Amanuel Baye, Abera Abreham, Abush Getaneh, Gizachew Taddesse Akalu, Alem Bayable, Birku Gashaw, Melaku Tsegaye, Geleta Gemechu, Mistire Wolde

Background: Uncontrolled type 2 diabetes mellitus (UT2DM) and its associated consequences nowadays have been a global health crisis, especially for adults. Iron has the property to oxidize and reduce reversibly, which is necessary for metabolic processes and excess accumulation of iron indicated by serum ferritin levels could have a significant impact on the pathophysiology of T2DM via generation of reactive oxygen species (ROS). However, no conclusive evidence existed about the association of serum ferritin with the state of glycemic control status. Therefore, this study aimed to evaluate serum ferritin levels and associated factors in uncontrolled T2DM patients and compare them with those of controlled T2DM and non-diabetic control groups.

Methods: A hospital-based comparative cross-sectional study was conducted among conveniently selected 156 study participants, who were categorized into three equal groups of uncontrolled T2DM, controlled T2DM, and non-diabetic control groups from October 2 to December 29, 2023 at St. Paul's Hospital Millennium Medical College. A pre-tested structured questionnaire was used to collect socio-demographic and diabetes-related information. The laboratory tests were done using an automated chemistry analyzer and IBM-SPSS statistical software (version-27) was utilized for data entry and analysis with a significance level of p < 0.05.

Result: The mean serum ferritin level was noticeably higher in uncontrolled T2DM patients as compared to controlled T2DM and control groups (p < 0.001). It was significantly correlated with HbA1c [r = 0.457, p < 0.001], fasting blood sugar (FBs) [r = 0.386, p < 0.001], serum iron [r = 0.430, p < 0.001], and systolic blood pressure (SBP) [r = 0.195, p = 0.047] in T2DM patients. A multivariate logistic regression model revealed that a rise in HbA1c (AOR = 3.67, 95% CI(1.50-8.98), serum iron (AOR = 1.02, 95% CI(1.01-1.04), male gender (AOR = 0.16, 95% CI(0.05-0.57) and being on oral hypoglycemic agent (OHA) monotherapy (AOR = 0.26, 95% CI(0.07-0.95) were key associated factors for the elevated serum ferritin among T2DM patients.

Conclusion: The present study demonstrated that T2DM patients had elevated serum ferritin levels which might be related to the existence of long-term hyperglycaemia and that serum ferritin had a significant positive association with HbA1c and FBs, implying that it could be used as an additional biomarker to predict uncontrolled T2DM patients.

背景:如今,不受控制的 2 型糖尿病(UT2DM)及其相关后果已成为全球性健康危机,尤其是对成年人而言。铁具有可逆氧化和还原的特性,是新陈代谢过程所必需的,血清铁蛋白水平所显示的铁的过量积累可通过产生活性氧(ROS)对 2 型糖尿病的病理生理学产生重大影响。然而,血清铁蛋白与血糖控制状况之间的关系尚无定论。因此,本研究旨在评估未控制 T2DM 患者的血清铁蛋白水平和相关因素,并将其与控制 T2DM 和非糖尿病对照组的血清铁蛋白水平和相关因素进行比较:方法:本研究于2023年10月2日至12月29日在圣保罗医院千禧医学院进行了一项以医院为基础的横断面比较研究,方便地选取了156名研究参与者,将其分为未控制T2DM组、控制T2DM组和非糖尿病对照组三个等量组。研究人员使用一份预先测试过的结构化问卷来收集社会人口学和糖尿病相关信息。使用自动化学分析仪进行实验室检测,并使用 IBM-SPSS 统计软件(27 版)进行数据录入和分析,显著性水平为 p 结果:与已控制的 T2DM 和对照组相比,未控制的 T2DM 患者的平均血清铁蛋白水平明显更高(p 结论:本研究表明,T2DM 患者血清铁蛋白水平升高可能与长期存在高血糖有关,而且血清铁蛋白与 HbA1c 和 FBs 呈显著正相关,这意味着血清铁蛋白可用作预测未控制 T2DM 患者的额外生物标志物。
{"title":"Serum ferritin level and associated factors among uncontrolled adult type II diabetic follow-up patients: comparative based cross-sectional study.","authors":"Andualem Bayih, Gobena Dedefo, Samuel Kinde, Mekdes Alem, Abebe Edao Negesso, Amanuel Baye, Abera Abreham, Abush Getaneh, Gizachew Taddesse Akalu, Alem Bayable, Birku Gashaw, Melaku Tsegaye, Geleta Gemechu, Mistire Wolde","doi":"10.1186/s12902-024-01665-7","DOIUrl":"10.1186/s12902-024-01665-7","url":null,"abstract":"<p><strong>Background: </strong>Uncontrolled type 2 diabetes mellitus (UT2DM) and its associated consequences nowadays have been a global health crisis, especially for adults. Iron has the property to oxidize and reduce reversibly, which is necessary for metabolic processes and excess accumulation of iron indicated by serum ferritin levels could have a significant impact on the pathophysiology of T2DM via generation of reactive oxygen species (ROS). However, no conclusive evidence existed about the association of serum ferritin with the state of glycemic control status. Therefore, this study aimed to evaluate serum ferritin levels and associated factors in uncontrolled T2DM patients and compare them with those of controlled T2DM and non-diabetic control groups.</p><p><strong>Methods: </strong>A hospital-based comparative cross-sectional study was conducted among conveniently selected 156 study participants, who were categorized into three equal groups of uncontrolled T2DM, controlled T2DM, and non-diabetic control groups from October 2 to December 29, 2023 at St. Paul's Hospital Millennium Medical College. A pre-tested structured questionnaire was used to collect socio-demographic and diabetes-related information. The laboratory tests were done using an automated chemistry analyzer and IBM-SPSS statistical software (version-27) was utilized for data entry and analysis with a significance level of p < 0.05.</p><p><strong>Result: </strong>The mean serum ferritin level was noticeably higher in uncontrolled T2DM patients as compared to controlled T2DM and control groups (p < 0.001). It was significantly correlated with HbA1c [r = 0.457, p < 0.001], fasting blood sugar (FBs) [r = 0.386, p < 0.001], serum iron [r = 0.430, p < 0.001], and systolic blood pressure (SBP) [r = 0.195, p = 0.047] in T2DM patients. A multivariate logistic regression model revealed that a rise in HbA1c (AOR = 3.67, 95% CI(1.50-8.98), serum iron (AOR = 1.02, 95% CI(1.01-1.04), male gender (AOR = 0.16, 95% CI(0.05-0.57) and being on oral hypoglycemic agent (OHA) monotherapy (AOR = 0.26, 95% CI(0.07-0.95) were key associated factors for the elevated serum ferritin among T2DM patients.</p><p><strong>Conclusion: </strong>The present study demonstrated that T2DM patients had elevated serum ferritin levels which might be related to the existence of long-term hyperglycaemia and that serum ferritin had a significant positive association with HbA1c and FBs, implying that it could be used as an additional biomarker to predict uncontrolled T2DM patients.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11305036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abnormal amino acid synthesis and glutathione metabolism may affect PCOS blastocyst development: an examination of in vitro mouse blastocysts model utilizing RNA-sequencing. 氨基酸合成和谷胱甘肽代谢异常可能影响多囊卵巢综合征囊胚的发育:利用 RNA 序列对体外小鼠囊胚模型进行的研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-06 DOI: 10.1186/s12902-024-01674-6
Chen Wang, Li Yu, Wei Cai, Te Liu, Miao Liu, Qi Che, Jianan Tang, Xuemei Wang, Xi Dong, Baishen Pan, Beili Wang, Suying Liu, Wei Guo

Background: Extensive research has been conducted on embryonic developmental disorders linked to Polycystic Ovary Syndrome (PCOS), a pathological condition that affects 5-10% of women and is characterized by irregularities in the menstrual cycle and infertility. By employing RNA sequencing (RNA-seq), we performed an in-depth investigation of PCOS-related changes in gene expression patterns at the mouse blastocyst stage.

Methods: The zygotes of female B6D2 mice were obtained and then differentiated into blastocysts in K + Simplex Optimised Medium (KSOM) cultures containing exo-NC (negative control for exosomes) or exo-LIPE-AS1 (a novel exosomal marker of PCOS). Subsequently, blastocysts were collected for RNA-seq. The bioinformatics was performed to analyze and compare the differences of gene expression profile between blastocysts of control and PCOS group.

Results: There were 1150 differentially expressed genes (DEGs) between the two groups of mouse blastocysts; 243 genes were upregulated and 907 downregulated in the blastocysts of the exo-LIPE-AS1 group compared to those of the exo-NC group. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the genes involved in amino acid synthesis and glutathione metabolic pathways were down-regulated in exo-LIPE-AS1 group.

Conclusion: This study has revealed that blastocyst developmental retardation may be associated with the downregulation of amino acid synthesis and glutathione metabolism, which may affect energy metabolism, biosynthesis, cellular osmotic pressure, antioxidant synthesis, ROS clearance or mitochondrial function, and ultimately cause blastocyst cell development abnormalities. Our research offers encouraging data on the mechanisms underlying aberrant embryonic development in patients with PCOS as well as potential treatment strategies.

背景:多囊卵巢综合征(PCOS)是一种影响5-10%女性的病理状况,其特征是月经周期不规律和不孕。通过使用 RNA 测序(RNA-seq),我们对小鼠囊胚期与多囊卵巢综合征相关的基因表达模式变化进行了深入研究:方法:获得雌性 B6D2 小鼠的子代,然后在含有外-NC(外泌体的阴性对照)或外-LIPE-AS1(PCOS 的新型外泌体标记物)的 K + Simplex Optimised Medium (KSOM) 培养基中分化成囊胚。随后,收集囊胚进行 RNA-seq。生物信息学分析和比较了对照组和多囊卵巢综合征组囊胚基因表达谱的差异:结果:两组小鼠囊胚中有1150个差异表达基因(DEGs);与exo-NC组相比,exo-LIPE-AS1组囊胚中有243个基因上调,907个基因下调。京都基因组百科全书(KEGG)通路分析显示,参与氨基酸合成和谷胱甘肽代谢通路的基因在外显子-LIPE-AS1 组中下调:本研究揭示了囊胚发育迟缓可能与氨基酸合成和谷胱甘肽代谢下调有关,这可能会影响能量代谢、生物合成、细胞渗透压、抗氧化剂合成、ROS 清除或线粒体功能,最终导致囊胚细胞发育异常。我们的研究为多囊卵巢综合症患者胚胎发育异常的机制以及潜在的治疗策略提供了令人鼓舞的数据。
{"title":"Abnormal amino acid synthesis and glutathione metabolism may affect PCOS blastocyst development: an examination of in vitro mouse blastocysts model utilizing RNA-sequencing.","authors":"Chen Wang, Li Yu, Wei Cai, Te Liu, Miao Liu, Qi Che, Jianan Tang, Xuemei Wang, Xi Dong, Baishen Pan, Beili Wang, Suying Liu, Wei Guo","doi":"10.1186/s12902-024-01674-6","DOIUrl":"10.1186/s12902-024-01674-6","url":null,"abstract":"<p><strong>Background: </strong>Extensive research has been conducted on embryonic developmental disorders linked to Polycystic Ovary Syndrome (PCOS), a pathological condition that affects 5-10% of women and is characterized by irregularities in the menstrual cycle and infertility. By employing RNA sequencing (RNA-seq), we performed an in-depth investigation of PCOS-related changes in gene expression patterns at the mouse blastocyst stage.</p><p><strong>Methods: </strong>The zygotes of female B6D2 mice were obtained and then differentiated into blastocysts in K + Simplex Optimised Medium (KSOM) cultures containing exo-NC (negative control for exosomes) or exo-LIPE-AS1 (a novel exosomal marker of PCOS). Subsequently, blastocysts were collected for RNA-seq. The bioinformatics was performed to analyze and compare the differences of gene expression profile between blastocysts of control and PCOS group.</p><p><strong>Results: </strong>There were 1150 differentially expressed genes (DEGs) between the two groups of mouse blastocysts; 243 genes were upregulated and 907 downregulated in the blastocysts of the exo-LIPE-AS1 group compared to those of the exo-NC group. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the genes involved in amino acid synthesis and glutathione metabolic pathways were down-regulated in exo-LIPE-AS1 group.</p><p><strong>Conclusion: </strong>This study has revealed that blastocyst developmental retardation may be associated with the downregulation of amino acid synthesis and glutathione metabolism, which may affect energy metabolism, biosynthesis, cellular osmotic pressure, antioxidant synthesis, ROS clearance or mitochondrial function, and ultimately cause blastocyst cell development abnormalities. Our research offers encouraging data on the mechanisms underlying aberrant embryonic development in patients with PCOS as well as potential treatment strategies.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arginine vasopressin deficiency onset after COVID-19 vaccination with positive anti-rabphilin-3A antibodies: a case report and literature review. 接种COVID-19疫苗后出现精氨酸加压素缺乏症,且抗虹膜睫状体-3A抗体呈阳性:病例报告和文献综述。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-06 DOI: 10.1186/s12902-024-01664-8
Hiroki Takizawa, Hiromasa Goto, Toyoyoshi Uchida, Shuhei Aoyama, Haruki Fujisawa, Naoko Iwata, Atsushi Suzuki, Yoshihisa Sugimura, Hirotaka Watada

Background: Arginine vasopressin deficiency (AVP-D) can occur due to various conditions, so clarifying its cause is important for deciding treatment strategy. Although several cases of AVP-D following coronavirus disease 2019(COVID-19) infection or COVID-19 vaccination have been reported, the diagnosis of the underlying disease has not been reported in most cases.

Case presentation: A 75-year-old woman who presented with polydipsia and polyuria 9 weeks after contracting COVID-19 and 5 weeks after receiving the SARS-CoV-2 vaccination, leading to the final diagnosis of AVP-D 8 months after the first appearance of symptoms. Interestingly, pituitary magnetic resonance imaging (MRI) still revealed stalk enlargement frequently observed in patients with SARS-CoV-2 vaccination-induced AVP-D. Although this finding could not rule out any malignancies, we additionally measured anti-rabphilin-3A antibodies, a known marker for lymphocytic infundibulo-neurohypophysitis (LINH), and found that the results were positive, strongly suggesting LINH as the cause of this disease. Thus, we avoided pituitary biopsy. At the follow-up MRI conducted 12 months after the initial consultation, enlargement of the pituitary stalk was still observed.

Conclusion: We experienced a case with LINH probably induced by SARS-CoV-2 vaccination. In SARS-CoV-2 vaccination-related LINH, unlike typical LINH, there is a possibility of persistent pituitary stalk enlargement on MRI images for an extended period, posing challenges in differential diagnosis from other conditions. Pituitary stalk enlargement and positive anti-rabphilin-3A antibodies may help in the diagnosis of AVP-D induced by SARS-CoV-2 vaccination.

背景:精氨酸加压素缺乏症(AVP-D)可由多种疾病引起,因此明确病因对于决定治疗策略非常重要。虽然已有多例因感染冠状病毒病2019(COVID-19)或接种COVID-19疫苗而导致AVP-D的病例报道,但大多数病例的基础疾病诊断尚未见报道:病例介绍:一名75岁的妇女在感染COVID-19病毒9周后和接种SARS-CoV-2疫苗5周后出现多尿多饮症状,在首次出现症状8个月后最终被诊断为AVP-D。有趣的是,垂体磁共振成像(MRI)仍然显示,SARS-CoV-2 疫苗接种诱发的 AVP-D 患者经常出现茎增大。虽然这一结果不能排除任何恶性肿瘤的可能性,但我们另外检测了抗蛛网膜-3A 抗体(一种已知的淋巴细胞性基金底-神经-肾上腺皮质炎(LINH)的标志物),结果呈阳性,强烈提示 LINH 是本病的病因。因此,我们避免了垂体活检。在初诊 12 个月后进行的磁共振随访中,仍观察到垂体柄增大:结论:我们经历了一例可能由接种 SARS-CoV-2 疫苗诱发的 LINH 病例。与典型的 LINH 不同,SARS-CoV-2 疫苗接种相关的 LINH 患者的核磁共振图像上垂体柄肿大可能会持续较长时间,这给与其他疾病的鉴别诊断带来了挑战。垂体柄增大和抗philin-3A抗体阳性可能有助于诊断SARS-CoV-2疫苗接种诱发的AVP-D。
{"title":"Arginine vasopressin deficiency onset after COVID-19 vaccination with positive anti-rabphilin-3A antibodies: a case report and literature review.","authors":"Hiroki Takizawa, Hiromasa Goto, Toyoyoshi Uchida, Shuhei Aoyama, Haruki Fujisawa, Naoko Iwata, Atsushi Suzuki, Yoshihisa Sugimura, Hirotaka Watada","doi":"10.1186/s12902-024-01664-8","DOIUrl":"10.1186/s12902-024-01664-8","url":null,"abstract":"<p><strong>Background: </strong>Arginine vasopressin deficiency (AVP-D) can occur due to various conditions, so clarifying its cause is important for deciding treatment strategy. Although several cases of AVP-D following coronavirus disease 2019(COVID-19) infection or COVID-19 vaccination have been reported, the diagnosis of the underlying disease has not been reported in most cases.</p><p><strong>Case presentation: </strong>A 75-year-old woman who presented with polydipsia and polyuria 9 weeks after contracting COVID-19 and 5 weeks after receiving the SARS-CoV-2 vaccination, leading to the final diagnosis of AVP-D 8 months after the first appearance of symptoms. Interestingly, pituitary magnetic resonance imaging (MRI) still revealed stalk enlargement frequently observed in patients with SARS-CoV-2 vaccination-induced AVP-D. Although this finding could not rule out any malignancies, we additionally measured anti-rabphilin-3A antibodies, a known marker for lymphocytic infundibulo-neurohypophysitis (LINH), and found that the results were positive, strongly suggesting LINH as the cause of this disease. Thus, we avoided pituitary biopsy. At the follow-up MRI conducted 12 months after the initial consultation, enlargement of the pituitary stalk was still observed.</p><p><strong>Conclusion: </strong>We experienced a case with LINH probably induced by SARS-CoV-2 vaccination. In SARS-CoV-2 vaccination-related LINH, unlike typical LINH, there is a possibility of persistent pituitary stalk enlargement on MRI images for an extended period, posing challenges in differential diagnosis from other conditions. Pituitary stalk enlargement and positive anti-rabphilin-3A antibodies may help in the diagnosis of AVP-D induced by SARS-CoV-2 vaccination.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary fatty acid pattern and its association with metabolic profile among overweight and obese adults. 超重和肥胖成年人的膳食脂肪酸模式及其与代谢状况的关系。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-05 DOI: 10.1186/s12902-024-01662-w
Reyhaneh Mokhtari Hemami, Mahdieh Abbasalizad Farhangi, Mohammad Dehghan Rouzi, Fatemeh Abdi

Background: Numerous studies have revealed the role of dietary fatty acids in human health. However, few studies have evaluated dietary fatty acid patterns and their association with metabolic parameters. The current study aimed to explore the association between dietary fatty acid patterns and risk factors for metabolic syndrome (MetS) among overweight and obese adults.

Methods: This cross-sectional study involved 340 participants who were overweight or obese. The study included assessments of body composition and anthropometric measurements. Dietary fatty acid consumption was evaluated using a validated Food Frequency Questionnaire (FFQ) containing 168 items. Additionally, biochemical parameters, including serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), fasting serum glucose (FSG), and insulin levels, were measured using enzymatic methods. Fatty acid patterns were determined by principal component analysis (PCA), and the association between these dietary FA patterns and risk factors related to MetS components was assessed using logistic regression.

Results: Factor analysis conducted in this study explored three dietary fatty acid patterns: saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA), and long-chain combined fatty acids (LC-CFA). Those at the highest tertile of the SFA pattern had lower diastolic blood pressure (DBP) (P = 0.03). Low-density lipoprotein cholesterol (LDL) was lower in the second and third tertiles (P ≤ 0.05). Also, higher fasting blood glucose (FBS) was observed in the second and third tertiles (P < 0.05), and the homeostatic model assessment of insulin resistance (HOMA-IR) was higher in the third tertile (P = 0.049). In the PUFA pattern, FBS was lower in the third tertile (P = 0.03). In the LC-CFA pattern, lower TC was achieved in higher tertiles (P = 0.04).

Conclusion: Our findings demonstrated that consuming high and moderate SFA patterns is associated with higher FBS and HOMA-IR. Also, increased consumption of SCFAs is related to lower DPB and LDL. Individuals who consumed more PUFA, especially linoleic acid, had lower FBS. These outcomes might be beneficial in managing MetS and leading to a new field of research.

背景:大量研究揭示了膳食脂肪酸对人体健康的作用。然而,很少有研究对膳食脂肪酸模式及其与代谢参数的关系进行评估。本研究旨在探讨超重和肥胖成年人的膳食脂肪酸模式与代谢综合征(MetS)风险因素之间的关联:这项横断面研究涉及 340 名超重或肥胖的参与者。研究包括身体成分评估和人体测量。膳食脂肪酸摄入量通过包含 168 个项目的有效食物频率问卷(FFQ)进行评估。此外,还使用酶法测量了生化参数,包括血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血清葡萄糖(FSG)和胰岛素水平。通过主成分分析(PCA)确定脂肪酸模式,并通过逻辑回归评估这些膳食脂肪酸模式与 MetS 成分相关风险因素之间的关联:本研究进行的因子分析探讨了三种膳食脂肪酸模式:饱和脂肪酸(SFA)、多不饱和脂肪酸(PUFA)和长链组合脂肪酸(LC-CFA)。饱和脂肪酸模式最高三分位数的人群舒张压(DBP)较低(P = 0.03)。低密度脂蛋白胆固醇(LDL)在第二和第三等分层中更低(P ≤ 0.05)。此外,还观察到第二和第三等分组的空腹血糖(FBS)较高(P 结语:我们的研究结果表明,摄入高、中、低脂蛋白胆固醇(LDL)的人的血糖水平较高:我们的研究结果表明,摄入大量和适量的 SFA 与较高的 FBS 和 HOMA-IR 有关。此外,摄入更多的 SCFA 与更低的 DPB 和 LDL 有关。摄入更多 PUFA(尤其是亚油酸)的人 FBS 更低。这些结果可能有益于控制 MetS,并将开辟一个新的研究领域。
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引用次数: 0
Prevalence and contributing factors of metabolic syndrome in rheumatoid arthritis patients. 类风湿性关节炎患者代谢综合征的患病率和诱因。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-05 DOI: 10.1186/s12902-024-01675-5
Zahra Bagheri-Hosseinabadi, Fatemeh Moadab, Mitra Abbasifard

Background: Promoting prevalence of metabolic syndrome (MetS) in Rheumatoid arthritis (RA) patients might occur secondary to RA therapy as well as sedentary life style. However, conflicting observations have been reported on the correlation between MetS and RA. This study aimed to determine the frequency of MetS and association of its components in RA.

Methods: In this study, 500 RA patients and 500 age- and gender-matched healthy controls were enrolled. MetS was fulfilled through the International Diabetes Federation (IDF) criteria. A multivariate regression model was used to control for variables independently associated with the risk of MetS in RA patients.

Results: The prevalence of MetS was 58.8% on IDF criteria in RA patients that was higher than controls (20.4%). Higher incidence of cardiovascular disease (CVD), the familial history of CVD, hypertension, type 2 diabetes mellitus (T2DM), smoking, dyslipidemia, and higher levels of body mass index (BMI), waist circumference (WC), total cholesterol level, fasting blood sugar (FBS), triglyceride (TG) level, low-density lipoprotein (LDL) level, while lower levels of high-density lipoprotein (HDL) were associated with an increased risk of MetS in RA patients. Multivariate regression analysis indicated that age, WC, dyslipidemia, LDL, and DAS28 were independent predictors of MetS in the RA patients.

Conclusions: The prevalence of MetS is higher in RA patients. Our findings suggest an association between cardiovascular risk factors and the increased prevalence of MetS in RA patients.

背景:类风湿性关节炎(RA)患者的代谢综合征(MetS)发病率增高可能与 RA 治疗和久坐不动的生活方式有关。然而,关于代谢综合征与 RA 之间相关性的报道却相互矛盾。本研究旨在确定MetS在RA中的发生频率及其各组成部分之间的关联:本研究共招募了 500 名 RA 患者和 500 名年龄与性别匹配的健康对照者。MetS符合国际糖尿病联盟(IDF)的标准。采用多变量回归模型控制与 RA 患者 MetS 风险独立相关的变量:根据 IDF 标准,RA 患者 MetS 患病率为 58.8%,高于对照组(20.4%)。心血管疾病(CVD)、家族性心血管疾病史、高血压、2 型糖尿病(T2DM)、吸烟、血脂异常以及体重指数(BMI)、腰围(WC)、总胆固醇水平、空腹血糖(FBS)、甘油三酯(TG)水平、低密度脂蛋白(LDL)水平较高,而高密度脂蛋白(HDL)水平较低,均与 RA 患者 MetS 风险增加有关。多变量回归分析表明,年龄、体重、血脂异常、低密度脂蛋白和 DAS28 是 RA 患者 MetS 的独立预测因素:结论:RA 患者的 MetS 患病率较高。我们的研究结果表明,心血管风险因素与 RA 患者 MetS 患病率增加之间存在关联。
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引用次数: 0
Vitamin D deficiency and the risk of diabetic retinopathy in patients with type 2 diabetes in Tibet: a cross-sectional analysis. 西藏 2 型糖尿病患者维生素 D 缺乏与糖尿病视网膜病变的风险:横断面分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-02 DOI: 10.1186/s12902-024-01668-4
Chuguang Chen, Shuyou Meng, Xiaolong Wu, Wangmu Ciren, Jing Shen, Zhuoma Zeding, Lihui Yang, Qing Tian, Xuemei Lv, Yunyi Le

Background: Diabetic retinopathy (DR) is one of the most common complications of diabetes worldwide. The aim of this study was to assess the prevalence of DR in hospitalized patients with type 2 diabetes (T2DM) in Tibet and to identify risk factors that may influence the occurrence of DR.

Methods: This was a cross-sectional study conducted in a third-class hospital in the Tibet Autonomous Region. The prevalence of DR in hospitalized patients with T2DM was measured. Univariate and multivariate logistic regression, restricted cubic spline (RCS) analysis and receiver-operating characteristic curve analysis were used to investigate the risk factors for DR.

Results: The prevalence of DR was 29.3%. The duration of diabetes; concentrations of 25-OH-VitD3, hemoglobin, fasting insulin, alanine aminotransferase, total bilirubin, and creatinine; and HOMA-IR were significantly different between DR patients and non-DR patients (all P < 0.05). Univariate and multivariate logistic regression revealed that a longer duration of diabetes and lower 25-OH-VitD3 levels were associated with increased DR risk. RCS analysis suggested overall positive associations of the duration of diabetes and 25-OH-VitD3 concentrations with DR risk (P nonlinearity < 0.05). The turning points for the duration of diabetes and 25-OH-VitD3 concentrations were 5.1 years and 10.6 ng/mL, respectively. The sensitivity, specificity, and area under the receiver-operating characteristic curve for the combination of the duration of diabetes and 25-OH-VitD3 levels were 79.4%, 69.4% and 0.764, respectively.

Conclusions: Given the high prevalence of DR in hospitalized patients with T2DM in Tibet, vitamin D supplementation seems to be important in the prevention of DR to some degree.

背景:糖尿病视网膜病变(DR)是全球最常见的并发症之一:糖尿病视网膜病变(DR)是全球最常见的糖尿病并发症之一。本研究旨在评估糖尿病视网膜病变在西藏住院的2型糖尿病(T2DM)患者中的发病率,并找出可能影响糖尿病视网膜病变发生的风险因素:这是一项在西藏自治区一家三甲医院进行的横断面研究。方法:这是一项在西藏自治区三级甲等医院进行的横断面研究,测量了T2DM住院患者中DR的患病率。采用单变量和多变量逻辑回归、限制性立方样条曲线(RCS)分析和受体运行特征曲线分析来研究DR的风险因素:DR的发病率为29.3%。糖尿病病程、25-OH-VitD3、血红蛋白、空腹胰岛素、丙氨酸氨基转移酶、总胆红素和肌酐的浓度以及 HOMA-IR 在 DR 患者和非 DR 患者之间存在显著差异(均为 P 结论:DR 的发病率为 29.3%:鉴于西藏住院的 T2DM 患者中 DR 患病率较高,补充维生素 D 似乎在一定程度上对预防 DR 有重要意义。
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引用次数: 0
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BMC Endocrine Disorders
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