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Knowledge of diabetes mellitus complication prevention among patients in the central region of Ghana. 加纳中部地区患者对糖尿病并发症预防知识的了解。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-03 DOI: 10.1186/s12902-024-01744-9
Christiana Asiedu, Evans Owusu-Berning, Isaac Aidoo Erzuah

Diabetes Mellitus (DM) is a serious worldwide health issue that has put pressure on the global economy. The study examined the knowledge of complication prevention among patients living with Diabetes Mellitus (DM) in Ghana. The research was a quantitative study which involved the use of descriptive cross-sectional survey design. In all, 301 DM patients were included in the study. Data were processed using the Statistical Package for the Social Sciences (SPSS) version 25. The study recorded 66.12% (n = 199) good knowledge level. Therefore, educational intervention programme should be organized by the health professionals at Twifo-Atti Morkwa hospital so every DM patient would have optimum knowledge about the disease that would ensure prevention of the DM complications.

糖尿病(DM)是一个严重的世界性健康问题,对全球经济造成了压力。本研究调查了加纳糖尿病(DM)患者对并发症预防知识的了解情况。研究采用描述性横断面调查设计,是一项定量研究。共有 301 名糖尿病患者参与了研究。数据使用社会科学统计软件包(SPSS)第 25 版进行处理。研究结果显示,66.12%(n = 199)的患者对糖尿病有良好的认知水平。因此,Twifo-Atti Morkwa 医院的医护人员应组织教育干预计划,使每位糖尿病患者都能获得最佳的疾病知识,从而确保预防糖尿病并发症。
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引用次数: 0
Assessments of coagulation profile among good glycemic control and poor glycemic control type 2 diabetic patient attending at Wolkite University specialized hospital, Central Ethiopia: a comparative study. 在埃塞俄比亚中部沃尔基特大学专科医院就诊的血糖控制良好和血糖控制不佳的 2 型糖尿病患者的凝血状况评估:一项比较研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01730-1
Bisrat Fikadu Habtu, Seid Abrar, Dereje Abebe, Zuber Hajikelil

Introduction: Diabetes Mellitus (DM) is a worldwide health issue that is defined by elevated blood glucose levels and impaired metabolism of fat, carbohydrates, and proteins. Atherosthrombotic events are very likely to occur in patients with diabetes mellitus. This results in the development of both microvascular and macrovascular complications.

Objective: To compare the coagulation profile parameters between patients with good glycemic control and poor glycemic control and to evaluate the association of coagulation profile and glycemic control in type 2 DM patients.

Materials and methods: This study was conducted in Wolkite university specialized hospital on 90 type 2 Diabetics patients among which 45 were with good glycemic control and 45 were with poor glycemic control. Seven ml blood samples were collected from each study participant and analyzed to assess coagulation profile including Platelet Count, activated Partial Thromboplastin Time (aPTT), and Prothrombin Time (PT). Using SPSS 21.0, an independent sample t-test was used for statistical analysis.

Results: According to the current study, when comparing Type 2 Diabetes with poor glycemic control to those with good glycemic control, there was an increase in PT and aPTT concentration (statistically significant, p < 0.05). The platelet counts of the two groups did not differ significantly.

Conclusion: People with Type 2 diabetes have altered coagulation profiles, which have demonstrated that hyperglycemia causes abnormalities in coagulation. Patients with Type 2 diabetes who have poor glycemic control are particularly vulnerable to atherothrombotic and hemorrhagic events. In order to prevent the onset of microvascular and macrovascular illness as soon as possible, physicians may find it helpful to evaluate the coagulation profile of diabetic patients.

简介糖尿病(DM)是一个世界性的健康问题,表现为血糖水平升高以及脂肪、碳水化合物和蛋白质的新陈代谢受损。糖尿病患者很容易发生动脉粥样硬化血栓事件。目的:比较糖尿病患者的凝血功能指标:比较血糖控制良好和血糖控制不佳患者的凝血谱参数,并评估 2 型糖尿病患者凝血谱与血糖控制的关联:本研究在沃尔凯特大学专科医院对 90 名 2 型糖尿病患者进行了研究,其中 45 名患者血糖控制良好,45 名患者血糖控制不佳。研究人员采集了每位患者的 7 毫升血液样本,并对其进行分析,以评估凝血情况,包括血小板计数、活化部分凝血活酶时间(aPTT)和凝血酶原时间(PT)。统计分析采用 SPSS 21.0 进行独立样本 t 检验:本次研究显示,血糖控制不佳的 2 型糖尿病患者与血糖控制良好的 2 型糖尿病患者相比,PT 和 aPTT 浓度增加(具有统计学意义,P 结论:血糖控制不佳的 2 型糖尿病患者与血糖控制良好的 2 型糖尿病患者相比,PT 和 aPTT 浓度增加(具有统计学意义,P 结论):2 型糖尿病患者的凝血功能会发生改变,这表明高血糖会导致凝血功能异常。血糖控制不佳的 2 型糖尿病患者特别容易发生动脉粥样血栓和出血事件。为了尽快预防微血管和大血管疾病的发生,医生可能会发现对糖尿病患者的凝血功能进行评估很有帮助。
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引用次数: 0
Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies. 二甲双胍治疗 2 型糖尿病患者的胃肠道不良反应:对观察性研究的系统回顾和元回归分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01727-w
Katarzyna Nabrdalik, Mirela Hendel, Krzysztof Irlik, Hanna Kwiendacz, Igor Łoniewski, Tommaso Bucci, Uazman Alam, Gregory Y H Lip, Janusz Gumprecht, Karolina Skonieczna-Żydecka

Introduction: Metformin is the most prescribed medication for type 2 diabetes mellitus (T2DM); there is a well-established link with the elevated incidence of gastrointestinal (GI) adverse events (AE) limiting its administration or intensification.

Objectives: The objective of this systematic review and meta-analysis of observational studies was to evaluate the pooled incidence of GI AE related to metformin use in patients with T2DM.

Materials and methods: PUB MED/CINAHL/Web of Science/Scopus were searched from database inception until 29.07.2024 for observational studies in English describing the frequency of GI AE in patients with T2DM treated with metformin. Random-effects meta-analyses were used to derive effect sizes: event rates.

Results: From 7019 publications, we identified 211 potentially eligible full-text articles. Ultimately, 21 observational studies were included in the meta-analysis. The prevalence of GI AE was as follows: diarrhea 6.9% (95% CI: 0.038-0.123), bloating 6,2% (95% CI: 0.020-0.177), abdominal pain 5,3% (95% CI: 0.003-0.529), vomiting 2.4% (95%: CI 0.007-0.075), constipation 1.1% (95%: CI 0.001-0.100). The incidence of bloating (coefficient -4.46; p < 0.001), diarrhea (coefficient -1.17; p = 0.0951) abdominal pain (coefficient -2.80; p = 0.001), constipation (coefficient -5.78; p = 0.0014) and vomiting (coefficient -2.47; p < 0.001) were lower for extended release (XR) metformin than metformin immediate release (IR) formulation.

Conclusions: This study highlights the prevalence of GI AE in patients receiving metformin, with a diarrhea predominance, followed by bloating, diarrhea, abdominal pain, constipation, and vomiting. The incidence is lower in patients administered with XR metformin.

Trial registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021289975 , identifier CRD42021289975.

简介二甲双胍是治疗 2 型糖尿病(T2DM)最常用的处方药;胃肠道不良事件(AE)发生率的升高限制了二甲双胍的使用或加强,这一点已得到公认:本观察性研究的系统综述和荟萃分析旨在评估与 T2DM 患者使用二甲双胍相关的胃肠道不良事件的总体发生率:从数据库建立之初到 2024 年 7 月 29 日,在 PUB MED/CINAHL/Web of Science/Scopus 上检索了描述二甲双胍治疗 T2DM 患者消化道 AE 发生率的英文观察性研究。采用随机效应荟萃分析得出效应大小:事件发生率:从 7019 篇出版物中,我们发现了 211 篇可能符合条件的全文文章。最终,21 项观察性研究被纳入荟萃分析。消化道 AE 的发生率如下:腹泻 6.9% (95% CI: 0.038-0.123)、腹胀 6.2% (95% CI: 0.020-0.177)、腹痛 5.3% (95% CI: 0.003-0.529)、呕吐 2.4% (95% CI: 0.007-0.075)、便秘 1.1% (95% CI: 0.001-0.100)。腹胀的发生率(系数-4.46;P 结论:该研究强调了胃肠道并发症的发生率:本研究强调了接受二甲双胍治疗的患者消化道 AE 的发生率,其中以腹泻为主,其次是腹胀、腹泻、腹痛、便秘和呕吐。使用XR二甲双胍的患者发病率较低。试验注册:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021289975 ,标识符为CRD42021289975。
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引用次数: 0
Postoperative pancytopenia in a patient with giant parathyroid adenoma and brown tumor: a case report. 一名患有巨大甲状旁腺腺瘤和棕色瘤的患者术后出现全血细胞减少:病例报告。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01742-x
Wen-Ting Pan, Zhi-Hong Zhao, Kun Wang, Zhi-Yuan He, Liang Ou

Background: Parathyroid adenoma is the primary cause of primary hyperparathyroidism, commonly presenting with elevated parathyroid hormone (PTH) and blood calcium levels. Chronic primary hyperparathyroidism often results in bone destruction, resulting in the formation of brown tumors. The preferred clinical treatment for parathyroid adenoma is parathyroidectomy. Postoperative pancytopenia, although rare, is a critical complication that warrants further investigation into its mechanisms and management strategies.

Case presentation: We present a case of a 59-year-old female patient who was admitted due to nausea and vomiting. Positron emission tomography-computed tomography (PET-CT) revealed a mass posterior to the left thyroid lobe and multiple areas of fibrocystic osteitis throughout the body. Hematological tests showed elevated serum calcium and parathyroid hormone (PTH) levels. The patient subsequently underwent parathyroidectomy, and pathological examination confirmed the presence of a parathyroid adenoma. Postoperatively, the patient developed pancytopenia and received symptomatic treatment such as correction of anemia and elevation of white blood. At the two-month follow-up, all indicators had returned to normal.

Conclusions: Pancytopenia is commonly seen in bone marrow diseases, infections and immune-related disorders, nutritional deficiencies, and metabolic diseases. This case confirms that pancytopenia can also occur postoperatively in patients with parathyroid adenoma. Therefore, Clinicians should be aware of the potential for postoperative pancytopenia following parathyroidectomy and the need for prompt management.

背景:甲状旁腺腺瘤是原发性甲状旁腺功能亢进症的主要病因,通常表现为甲状旁腺激素(PTH)和血钙水平升高。慢性原发性甲状旁腺功能亢进通常会导致骨质破坏,形成褐色肿瘤。甲状旁腺腺瘤的首选临床治疗方法是甲状旁腺切除术。术后全血细胞减少虽然罕见,但却是一种严重的并发症,需要进一步研究其机制和治疗策略:我们介绍了一例 59 岁的女性患者,她因恶心和呕吐入院。正电子发射计算机断层扫描(PET-CT)显示左甲状腺叶后方有肿块,全身多处有纤维囊性骨炎。血液学检查显示血清钙和甲状旁腺激素(PTH)水平升高。患者随后接受了甲状旁腺切除术,病理检查证实了甲状旁腺腺瘤的存在。术后,患者出现全血细胞减少,接受了纠正贫血和升高白细胞等对症治疗。在两个月的随访中,所有指标均恢复正常:全血细胞减少症常见于骨髓疾病、感染和免疫相关疾病、营养缺乏和代谢性疾病。本病例证实,甲状旁腺腺瘤患者术后也可能出现全血细胞减少。因此,临床医生应意识到甲状旁腺切除术后可能会出现全血细胞减少的情况,并需要及时处理。
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引用次数: 0
Insulin resistance and insulin secretory defect among Bangalee PCOS women: a case-control study. 班加罗尔多囊卵巢综合征妇女的胰岛素抵抗和胰岛素分泌缺陷:一项病例对照研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01720-3
Jannatul Nayeem, M M Towhidul Islam, Farzana Deeba, Shahjada Selim, Liaquat Ali, Yearul Kabir

Insulin resistance (IR) is a well-recognized covariate of Polycystic Ovarian Syndrome (PCOS) with varying burden and risk factors among populations. The relationship of insulin secretory defect or ISD with PCOS is less understood. The presence of IR and ISD as well as their covariates have been explored in the present case-control study among young adult to early middle-aged, normal weight to obese, Bangalee women with PCOS. A number of 158 PCOS [age 23 (15-34) years, Median (Range)] and 126 Non-PCOS [24 (19-34) years] females were recruited purposively with PCOS diagnosed following Modified Rotterdam Criteria 2003. Hormones were measured by CLIA method and lower abdominal ultrasonography was done by trained personnel. IR and ISD were assessed by homeostasis model assessment with 75th percentile values of HOMA-IR (2.4) and HOMA%B (143) in Non-PCOS group considered as the cut-off values. Hyperandrogenism (HA) was measured by calculating Fasting Androgen Index (FAI). HOMA-IR was high among 52% of PCOS and 28% of Non-PCOS women. Body Mass Index (BMI) and HA were independently associated covariates of IR (p < 0.001). HOMA%B was compromised among 48% of PCOS subjects and the deficiency showed independent association (p < 0.001) with 2 h glycemia on OGTT in Non-PCOS and HA in PCOS groups. The data suggest insulin resistance as a major risk factor for PCOS among Bangalee women with obesity and hyperandrogenemia as its major covariates. The findings also indicate that presence of impaired insulin secretion is a major determinant of hyperglycemia and, consequently, of higher T2DM risk among young women in this population.

胰岛素抵抗(IR)是多囊卵巢综合征(PCOS)的一个公认的协变量,其负担和风险因素在不同人群中各不相同。胰岛素分泌缺陷(ISD)与多囊卵巢综合征的关系还不太清楚。本病例对照研究对患有多囊卵巢综合症的年轻成人至中年早期、体重正常至肥胖的班加罗尔妇女进行了研究,探讨了 IR 和 ISD 的存在及其协变量。研究有目的性地招募了 158 名多囊卵巢综合症女性(年龄 23(15-34)岁,中位数(范围))和 126 名非多囊卵巢综合症女性(24(19-34)岁),她们都是根据 2003 年修订的鹿特丹标准诊断出的多囊卵巢综合症患者。激素采用 CLIA 方法进行测量,下腹部超声波检查由受过培训的人员进行。以非多囊卵巢综合征组的 HOMA-IR 第 75 百分位值(2.4)和 HOMA%B 第 75 百分位值(143)为临界值,通过稳态模型评估 IR 和 ISD。高雄激素症(HA)通过计算空腹雄激素指数(FAI)来衡量。52% 的多囊卵巢综合症妇女和 28% 的非多囊卵巢综合症妇女的 HOMA-IR 偏高。体重指数(BMI)和 HA 是 IR 的独立相关协变量(p
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引用次数: 0
Associations of metabolic syndrome and its components with sarcopenia, and the mediating role of insulin resistance: Findings from NHANES database. 代谢综合征及其组成部分与肌肉疏松症的关系,以及胰岛素抵抗的中介作用:来自 NHANES 数据库的研究结果。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01736-9
Minghui Li, Rong Ji, Xi Liu, Yongjian Wu

Background: To investigate the association between metabolic syndrome (MetS) and its components with sarcopenia, and to explore the extent to which insulin resistance (IR) mediates this association, using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: We analyzed cross-sectional data from 15,779 adults in the NHANES from 1999 to 2006 and 2011-2018. Multivariable logistic regression models were used to determine the odds ratios (ORs) between MetS, its components, the number of MetS components, and sarcopenia. Mediation analysis was performed to explore the role of the homeostatic model assessment of insulin resistance (HOMA-IR) in MetS and its components-induced sarcopenia.

Result: In the fully adjusted model, MetS increased the prevalence of sarcopenia by 1.96-fold (95% CI: 1.73-2.22). Among the individual components, central obesity, hypertension, and hyperglycemia were associated with an increased prevalence of sarcopenia. Sarcopenia prevalence also increased linearly with the number of MetS components, with the highest prevalence observed in the presence of all five components (OR: 3.80, 95% CI: 2.79-5.16). Sex-stratified analysis showed that the prevalence of MetS for sarcopenia was higher in males than females. The mediating effects of HOMA-IR on the association between MetS and its components (central obesity, hypertension, and hyperglycemia) with sarcopenia were significant, with mediation effects of 51.7%, 30.7%, 33.2%, and 79.1%, respectively. There was no significant direct association between hyperglycemia and sarcopenia beyond the HOMA-IR pathway.

Conclusion: MetS and its individual components, excluding hypertriglyceridemia and low high density lipoprotein cholesterol, were associated with a higher prevalence of sarcopenia, especially in males. This association was partially or fully mediated by IR.

背景:利用美国国家健康与营养调查(NHANES)的数据,研究代谢综合征(MetS)及其成分与肌肉疏松症之间的关联,并探讨胰岛素抵抗(IR)在多大程度上介导了这种关联:我们分析了1999-2006年和2011-2018年NHANES调查中15779名成年人的横断面数据。采用多变量逻辑回归模型确定 MetS、其成分、MetS 成分数量和肌少症之间的几率比(ORs)。研究人员还进行了中介分析,以探讨胰岛素抵抗的稳态模型评估(HOMA-IR)在MetS及其成分诱发的肌肉疏松症中的作用:结果:在完全调整模型中,MetS 使肌肉疏松症的患病率增加了 1.96 倍(95% CI:1.73-2.22)。在各个组成部分中,中心性肥胖、高血压和高血糖与肌肉疏松症患病率增加有关。肌肉疏松症的患病率也随着 MetS 成分的数量呈线性增长,当所有五个成分都存在时,患病率最高(OR:3.80,95% CI:2.79-5.16)。性别分层分析显示,肌肉疏松症的 MetS 患病率男性高于女性。HOMA-IR对MetS及其组成部分(中心性肥胖、高血压和高血糖)与肌肉疏松症之间的关联有显著的中介效应,中介效应分别为51.7%、30.7%、33.2%和79.1%。除 HOMA-IR 途径外,高血糖与肌肉疏松症之间没有明显的直接关联:结论:除高甘油三酯血症和低高密度脂蛋白胆固醇外,MetS 及其各个组成部分与较高的肌肉疏松症发病率有关,尤其是在男性中。这种关联部分或完全由 IR 介导。
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引用次数: 0
Risk and determinants of sarcopenia in people with diabetes: a case-control study from Qatar Biobank cohort. 糖尿病患者患肌肉疏松症的风险和决定因素:一项来自卡塔尔生物库队列的病例对照研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01722-1
Hibeh Shatila, Nour Ghazal, Ghalya Bukshaisha, Shaikha Al-Zeyara, Cosette Fakih El Khoury, Maya Bassil

Background: Diabetes is associated with impairments in muscle mass and quality increasing the risk of sarcopenia. Thus, this study aimed to investigate the odds of sarcopenia and its associated risk factors among Qatari adults (> 18 years), while exploring the modulating effects of health and lifestyle factors.

Methods: Using a case-control design, data from 767 participants (481 cases with diabetes and 286 controls without diabetes) was collected from Qatar Biobank (QBB). Sociodemographic, lifestyle factors including dietary intake, anthropometric and biochemical measures were analyzed. Handgrip strength, Dual X-ray absorptiometry (DXA), and Bio-impedance were used to assess muscle strength, muscle mass and muscle quality, respectively. The risk of sarcopenia was estimated using the European consensus on definition and diagnosis of sarcopenia.

Results: Cases with diabetes were older (55 vs. 36 years; P < 0.001), had higher BMI (31.6 vs. 28.3 kg/m2; P < 0.001), lower cardiorespiratory fitness (50.0% "Moderate" fitness for cases, 62.9% "High" fitness for controls), and consumed less total (59.0 vs. 64.0; P = 0.004) and animal protein (39.0 vs. 42.0; P = 0.001), compared to controls based on a computed score. Participants with diabetes also had lower appendicular lean mass/BMI, handgrip strength, and higher probability of sarcopenia/probable sarcopenia (P < 0.005). Adjusted multiple logistic regression revealed that elevated cardiorespiratory fitness (β = 0.299, 95%CI:0.12-0.74) and blood triglycerides (β = 1.475, 95% CI: 1.024-2.124), as well as being a female (β = 0.086, 95%CI: 0.026-0.288) and having higher BMI (β = 0.908, 95%CI: 0.852-0.967) and ALM/BMI (β = 0.000, 95% CI: 0.000-0.007) are independent predictors (p < 0.05) of sarcopenia risk.

Conclusions: This study highlights the intricate relationship between diabetes and sarcopenia, revealing modifiable risk factors. Individuals with diabetes were found to have a higher likelihood of sarcopenia, which was associated with lower fitness levels and higher blood triglycerides. Protective factors against sarcopenia included being female and having higher BMI and ALM/BMI ratios.

背景:糖尿病与肌肉质量和质量受损有关,会增加患肌肉疏松症的风险。因此,本研究旨在调查卡塔尔成年人(18 岁以上)患肌肉疏松症的几率及其相关风险因素,同时探讨健康和生活方式因素的调节作用:采用病例对照设计,从卡塔尔生物库(Qatar Biobank,QBB)中收集了 767 名参与者(481 名糖尿病患者和 286 名非糖尿病对照者)的数据。对社会人口学、生活方式因素(包括饮食摄入量)、人体测量和生化指标进行了分析。手握力、双 X 射线吸收测量(DXA)和生物阻抗分别用于评估肌肉力量、肌肉质量和肌肉质量。根据欧洲关于肌肉疏松症定义和诊断的共识,对肌肉疏松症的风险进行了估计:结果:患有糖尿病的病例年龄更大(55 岁对 36 岁;P 结论:糖尿病与肌肉疏松症之间存在着错综复杂的关系:这项研究强调了糖尿病与肌肉疏松症之间错综复杂的关系,揭示了可改变的风险因素。研究发现,糖尿病患者患肌肉疏松症的可能性较高,这与体能水平较低和血甘油三酯较高有关。防止肌肉疏松症的保护因素包括女性、较高的体重指数和ALM/BMI比率。
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引用次数: 0
Hyperandrogenism and anthropometric parameters in women with polycystic ovary syndrome. 多囊卵巢综合征妇女的高雄激素和人体测量参数。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-27 DOI: 10.1186/s12902-024-01733-y
Asieh Mansour, Maryam Noori, Monir Sadat Hakemi, Ziba Haghgooyan, Mohammad Reza Mohajeri-Tehrani, Maryam Mirahmad, Sayed Mahmoud Sajjadi-Jazi

Objective: One of the main features of polycystic ovary syndrome (PCOS) is increased adipose tissue, which can result in hormonal disturbances. In the present study, we aimed to investigate which indicator of obesity could better associate with hormonal disturbances in PCOS women.

Methods: In this cross-sectional analysis, women with PCOS were included according to the Rotterdam criteria. Fasting blood samples were analyzed for biochemical, metabolic, and hormonal parameters. Anthropometric measures comprised body composition indices (assessed by bioelectric impedance analysis [BIA]), waist circumference, body mass index (BMI), and waist-to-height ratio (WHtR). Linear regression modeling was used to assess the association between anthropometric indices and hormonal imbalance, adjusted for age, mensuration status, and the homeostasis model assessment-estimated insulin resistance (HOMA-IR). Receiver operating characteristics (ROC) curves were utilized to ascertain the sensitivity, specificity, and optimal cut-off points of various anthropometric indices in identifying hyperandrogenism.

Results: A total of 129 PCOS women with a median (interquartile range [IQR]) age of 32.0 (23.0-32.0) years and a median BMI of 26.3 (23.00-29.70) kg/m2 were enrolled. In the adjusted linear regression model, BMI (β = 0.053, P < 0.001), waist circumference (β = 0.021, P = 0.001), WHtR (β = 3.325, P = 0.002), total fat mass (β = 0.021, P = 0.002), trunk fat mass (β = 0.038, P = 0.006), and leg fat mass (β = 0.045, P = 0.004) were positively associated with free androgen index (FAI). In addition, BMI (β=-0.017, P = 0.003), waist circumference (β=-0.008, P = 0.002), WHtR (β=-1.167, P = 0.004), total fat mass (β=-0.008, P=0.003), trunk fat mass (β=-0.017, P=0.001), and leg fat mass (β=-0.018, P=0.004) were negatively associated with the serum level of sex hormone binding globulin (SHBG). WHtR showed the greatest area under the curve (AUC) value (AUC = 0.676, P = 0.001) for identifying hyperandrogenism (FAI ≥ 4.97 or total testosterone ≥ 0.7 ng/mL) in PCOS women with corresponding sensitivity of 87.30% and specificity of 39.70%.

Conclusions: WHtR is related to hyperandrogenism in PCOS better than other anthropometric measures.

目的:多囊卵巢综合征(PCOS)的主要特征之一是脂肪组织增加,这会导致激素紊乱。在本研究中,我们旨在调查哪种肥胖指标能更好地与多囊卵巢综合征妇女的激素紊乱相关联:在这项横断面分析中,根据鹿特丹标准纳入了患有多囊卵巢综合症的女性。对空腹血液样本进行了生化、代谢和激素参数分析。人体测量指标包括身体成分指数(通过生物电阻抗分析[BIA]评估)、腰围、体重指数(BMI)和腰围身高比(WHtR)。线性回归模型用于评估人体测量指数与荷尔蒙失衡之间的关系,并对年龄、体质状况和稳态模型评估-估计胰岛素抵抗(HOMA-IR)进行了调整。利用受体操作特征曲线(ROC)来确定各种人体测量指标在识别高雄激素症方面的敏感性、特异性和最佳临界点:共纳入了 129 名多囊卵巢综合征女性,中位(四分位间[IQR])年龄为 32.0(23.0-32.0)岁,中位体重指数为 26.3(23.00-29.70)kg/m2。在调整后的线性回归模型中,BMI(β = 0.053,P 结论:WHtR 与高胆固醇血症有关:与其他人体测量指标相比,WHtR 与多囊卵巢综合征的高雄激素相关性更好。
{"title":"Hyperandrogenism and anthropometric parameters in women with polycystic ovary syndrome.","authors":"Asieh Mansour, Maryam Noori, Monir Sadat Hakemi, Ziba Haghgooyan, Mohammad Reza Mohajeri-Tehrani, Maryam Mirahmad, Sayed Mahmoud Sajjadi-Jazi","doi":"10.1186/s12902-024-01733-y","DOIUrl":"https://doi.org/10.1186/s12902-024-01733-y","url":null,"abstract":"<p><strong>Objective: </strong>One of the main features of polycystic ovary syndrome (PCOS) is increased adipose tissue, which can result in hormonal disturbances. In the present study, we aimed to investigate which indicator of obesity could better associate with hormonal disturbances in PCOS women.</p><p><strong>Methods: </strong>In this cross-sectional analysis, women with PCOS were included according to the Rotterdam criteria. Fasting blood samples were analyzed for biochemical, metabolic, and hormonal parameters. Anthropometric measures comprised body composition indices (assessed by bioelectric impedance analysis [BIA]), waist circumference, body mass index (BMI), and waist-to-height ratio (WHtR). Linear regression modeling was used to assess the association between anthropometric indices and hormonal imbalance, adjusted for age, mensuration status, and the homeostasis model assessment-estimated insulin resistance (HOMA-IR). Receiver operating characteristics (ROC) curves were utilized to ascertain the sensitivity, specificity, and optimal cut-off points of various anthropometric indices in identifying hyperandrogenism.</p><p><strong>Results: </strong>A total of 129 PCOS women with a median (interquartile range [IQR]) age of 32.0 (23.0-32.0) years and a median BMI of 26.3 (23.00-29.70) kg/m<sup>2</sup> were enrolled. In the adjusted linear regression model, BMI (β = 0.053, P < 0.001), waist circumference (β = 0.021, P = 0.001), WHtR (β = 3.325, P = 0.002), total fat mass (β = 0.021, P = 0.002), trunk fat mass (β = 0.038, P = 0.006), and leg fat mass (β = 0.045, P = 0.004) were positively associated with free androgen index (FAI). In addition, BMI (β=-0.017, P = 0.003), waist circumference (β=-0.008, P = 0.002), WHtR (β=-1.167, P = 0.004), total fat mass (β=-0.008, P=0.003), trunk fat mass (β=-0.017, P=0.001), and leg fat mass (β=-0.018, P=0.004) were negatively associated with the serum level of sex hormone binding globulin (SHBG). WHtR showed the greatest area under the curve (AUC) value (AUC = 0.676, P = 0.001) for identifying hyperandrogenism (FAI ≥ 4.97 or total testosterone ≥ 0.7 ng/mL) in PCOS women with corresponding sensitivity of 87.30% and specificity of 39.70%.</p><p><strong>Conclusions: </strong>WHtR is related to hyperandrogenism in PCOS better than other anthropometric measures.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are ultrasonographic scoring systems of the salivary gland in primary Sjögren's syndrome suitable for examination of Type2 diabetes mellitus patients with sicca? 原发性 Sjögren's 综合征唾液腺超声评分系统是否适用于 2 型糖尿病患者的筛查?
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-27 DOI: 10.1186/s12902-024-01740-z
Abdulvahap Kahveci, Alper Gümüştepe, İsmihan Sunar, Şebnem Ataman

Objective: This study aimed to compare the salivary gland ultrasonography(SGUS) findings in patients with primary Sjögren's Syndrome (pSS) and diabetes mellitus(DM) patients with sicca symptoms and to examine the relationship between salivary gland ultrasonography (SGUS) findings with clinical and laboratory parameters.

Methods: In this study, 34 patients with pSS and 34 DM patients with sicca symptoms were included. In all patients, bilateral parotid, and submandibular gland ultrasonography (totally 272 glands) was performed by blinded rheumatologist, using the Hocevar and the Outcome Measures in Rheumatology (OMERACT) scoring system. Clinic and ultrasonographic variables were compared between groups. The association between SGUS score and disease duration was analyzed by correlation analysis.

Results: Patients with pSS presented significantly higher SGUS scores than patients with DM (the Hocevar score; 20.93(± 9.65) vs. 3.82(± 3.71); p < 0.05, the OMERACT score; 5.96(± 2.30) vs. 2.07(± 1.65); p < 0.05, respectively). In patients with pSS, the submandibular gland scores were significantly higher than the parotid gland scores (right; p < 0.05 vs. left; p < 0.01) while DM patients showed significantly higher parotid gland scores (right; p < 0.05 vs. left; p < 0.05). In pSS patients, the SGUS scores were associated with disease duration (r = 0.57; r = 0.50; p < 0.05), symptom duration (r = 50; r = 0.47; p < 0.05), and the European League Against Rheumatism Sjögren's Syndrome Patient Reported Index (ESSPRI)-dryness score (r = 0.35, r = 0.36; p < 0.05). However, in DM patients, the SGUS scores are highly correlated with the ESSPRI-dryness (r = 0.74, r = 0.72; p < 0.05) and HbA1C level (r = 0.91, r = 0.86; p < 0.05).

Conclusions: This study demonstrated that major salivary gland involvement was more severe and correlated with disease duration, and submandibular gland was dominantly affected in pSS. Contrarily, in DM patients, salivary gland involvement was milder, parotid dominant and related to level of dryness and HbA1C, rather than disease duration when compared to pSS.

研究目的本研究旨在比较原发性斯约格伦综合征(pSS)患者和糖尿病(DM)患者唾液腺超声检查(SGUS)结果,并探讨唾液腺超声检查(SGUS)结果与临床和实验室指标之间的关系:方法:本研究共纳入34名腮腺肿大症患者和34名有睑板腺症状的糖尿病(DM)患者。所有患者的双侧腮腺和颌下腺超声波检查(共 272 个腺体)均由风湿病学盲人医生进行,并采用 Hocevar 和风湿病学结果测量(OMERACT)评分系统。对各组的临床和超声变量进行了比较。通过相关性分析分析了SGUS评分与病程之间的关系:结果:pSS 患者的 SGUS 评分明显高于 DM 患者(Hocevar 评分:20.93(±9.65)分 vs. 3.82(±3.71)分;p 结论:该研究表明,唾液腺的主要功能是分泌唾液:本研究表明,主要唾液腺受累更严重,且与病程相关,颌下腺在 pSS 中主要受累。相反,与 pSS 相比,DM 患者的唾液腺受累程度较轻,以腮腺为主,与干燥程度和 HbA1C 相关,而与病程无关。
{"title":"Are ultrasonographic scoring systems of the salivary gland in primary Sjögren's syndrome suitable for examination of Type2 diabetes mellitus patients with sicca?","authors":"Abdulvahap Kahveci, Alper Gümüştepe, İsmihan Sunar, Şebnem Ataman","doi":"10.1186/s12902-024-01740-z","DOIUrl":"https://doi.org/10.1186/s12902-024-01740-z","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the salivary gland ultrasonography(SGUS) findings in patients with primary Sjögren's Syndrome (pSS) and diabetes mellitus(DM) patients with sicca symptoms and to examine the relationship between salivary gland ultrasonography (SGUS) findings with clinical and laboratory parameters.</p><p><strong>Methods: </strong>In this study, 34 patients with pSS and 34 DM patients with sicca symptoms were included. In all patients, bilateral parotid, and submandibular gland ultrasonography (totally 272 glands) was performed by blinded rheumatologist, using the Hocevar and the Outcome Measures in Rheumatology (OMERACT) scoring system. Clinic and ultrasonographic variables were compared between groups. The association between SGUS score and disease duration was analyzed by correlation analysis.</p><p><strong>Results: </strong>Patients with pSS presented significantly higher SGUS scores than patients with DM (the Hocevar score; 20.93(± 9.65) vs. 3.82(± 3.71); p < 0.05, the OMERACT score; 5.96(± 2.30) vs. 2.07(± 1.65); p < 0.05, respectively). In patients with pSS, the submandibular gland scores were significantly higher than the parotid gland scores (right; p < 0.05 vs. left; p < 0.01) while DM patients showed significantly higher parotid gland scores (right; p < 0.05 vs. left; p < 0.05). In pSS patients, the SGUS scores were associated with disease duration (r = 0.57; r = 0.50; p < 0.05), symptom duration (r = 50; r = 0.47; p < 0.05), and the European League Against Rheumatism Sjögren's Syndrome Patient Reported Index (ESSPRI)-dryness score (r = 0.35, r = 0.36; p < 0.05). However, in DM patients, the SGUS scores are highly correlated with the ESSPRI-dryness (r = 0.74, r = 0.72; p < 0.05) and HbA1C level (r = 0.91, r = 0.86; p < 0.05).</p><p><strong>Conclusions: </strong>This study demonstrated that major salivary gland involvement was more severe and correlated with disease duration, and submandibular gland was dominantly affected in pSS. Contrarily, in DM patients, salivary gland involvement was milder, parotid dominant and related to level of dryness and HbA1C, rather than disease duration when compared to pSS.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11430209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid functions and insulin resistance in pregnant Sudanese women. 苏丹孕妇的甲状腺功能和胰岛素抵抗。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-27 DOI: 10.1186/s12902-024-01739-6
Wisal Abbas, Abdelmageed Elmugabil, Duria A Rayis, Ishag Adam, Hamdan Z Hamdan

Background: The thyroid function test (free triiodothyronine [FT3], free thyroxine [FT4], and thyroid-stimulating hormone [TSH]) is one of the key determinant of glucose homeostasis by regulating the balance of insulin. Thyroid dysfunction alters glucose metabolism, leading to insulin resistance (IR). This study aimed to assess the association between thyroid function and IR in pregnant Sudanese women.

Method: A cross-sectional study was conducted in Saad Abuelela Hospital, Khartoum-Sudan, from January to April 2021. Obstetric/sociodemographic characteristics were gathered through questionnaires. Serum TSH, FT3, FT4, fasting plasma glucose (FPG), and fasting insulin levels were measured and evaluated, and IR was estimated using the homeostatic model assessment for insulin resistance (HOMA-IR) equation.

Results: In total, the study included 127 pregnant women with a median age of 27.0 years (interquartile range [IQR] 23.0‒31.2) and a median gestational (IQR) age of 25.0 (IQR 25.0‒27.0) weeks. The medians (IQRs) of the TSH, FT3, and FT4 were 1.600 (1.162‒2.092) IU/ml, 2.020(1.772‒2.240) nmol/l, and 10.70 (9.60‒11.90) pmol/l, respectively. The median (IQR) of the FPG and fasting blood insulin level was [69.0 (62.00‒78.00) mg/dl] and [5.68(2.99‒11.66) IU/ml], respectively. The median (IQR) of the HOMA-IR level was 0.9407 (0.4356‒2.1410). There was a positive correlation between HOMA -IR and FT3 levels (r = 0.375; P < 0.001) and a negative correlation with FT4 levels (r= -0.312; P < 0.001). Also, a significant positive correlation was found between fasting insulin levels and FT3 levels (r = 0.438; P < 0.001) and a negative correlation with FT4 levels (r= -0.305; P < 0.001).

Conclusions: This study indicated that FT3 has positive correlation with HOMA-IR, while FT4 has negative correlation among healthy pregnant women without a history of thyroid dysfunction. This may indicate screening of euthyroid pregnant women for thyroid dysfunction and IR. Further studies are needed.

背景:甲状腺功能检测(游离三碘甲状腺原氨酸[FT3]、游离甲状腺素[FT4]和促甲状腺激素[TSH])通过调节胰岛素的平衡,是决定葡萄糖平衡的关键因素之一。甲状腺功能障碍会改变葡萄糖代谢,导致胰岛素抵抗(IR)。本研究旨在评估苏丹孕妇甲状腺功能与 IR 之间的关系:一项横断面研究于 2021 年 1 月至 4 月在苏丹喀土穆的 Saad Abuelela 医院进行。通过问卷调查收集了产科/社会人口学特征。测量并评估了血清促甲状腺激素(TSH)、胰岛素转换酶3(FT3)、胰岛素转换酶4(FT4)、空腹血浆葡萄糖(FPG)和空腹胰岛素水平,并使用胰岛素抵抗稳态模型评估(HOMA-IR)方程估算了IR:研究共纳入了 127 名孕妇,中位年龄为 27.0 岁(四分位数间距 [IQR] 23.0-31.2),中位孕周(IQR)为 25.0 周(IQR 25.0-27.0)。TSH、FT3和FT4的中位数(IQR)分别为1.600(1.162-2.092)IU/ml、2.020(1.772-2.240)nmol/l和10.70(9.60-11.90)pmol/l。FPG 和空腹血胰岛素水平的中位数(IQR)分别为[69.0 (62.00-78.00) mg/dl]和[5.68(2.99-11.66) IU/ml]。HOMA-IR 水平的中位数(IQR)为 0.9407(0.4356-2.1410)。HOMA -IR与FT3水平呈正相关(r = 0.375; P 结论:HOMA -IR与FT3水平呈正相关:本研究表明,在无甲状腺功能障碍病史的健康孕妇中,FT3 与 HOMA-IR 呈正相关,而 FT4 呈负相关。这可能预示着要对甲状腺功能正常的孕妇进行甲状腺功能障碍和IR筛查。还需要进一步研究。
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引用次数: 0
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BMC Endocrine Disorders
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