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Retraction Note: Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis. 摘要:膳食多酚与代谢综合征的风险:一项系统综述和荟萃分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-12 DOI: 10.1186/s12902-024-01810-2
Pushpamala Ramaiah, Kamilya Jamel Baljon, Ahmed Hjazi, Maytham T Qasim, Omar Abdulwahid Salih Al-Ani, Shad Imad, Beneen M Hussien, Ali Alsalamy, Nazila Garousi
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引用次数: 0
Glycemic control and associated factors in patients with type 2 diabetes in Southwest Ethiopia: a prospective observational study. 埃塞俄比亚西南部2型糖尿病患者的血糖控制及相关因素:一项前瞻性观察研究
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-05 DOI: 10.1186/s12902-024-01795-y
Aster Wakjira Garedo, Gorfineh Teshome Tesfaye, Rahel Tamrat, Evelien Wynendaele

Background: Diabetes, a known syndrome marked by hyperglycemia and glucose intolerance, is increasing at an alarming rate worldwide. Over half a billion people worldwide have DM, and most live in low- and middle-income countries. Poor glycemic control is a public health concern in type 2 diabetes mellitus. Glycemic control and identifying factors associated with poor glycemic control can help healthcare providers design programs that improve glycemic control and the quality of services provided to patients.

Objectives: This study was designed to assess the level of glycemic control and associated factors in patients with type 2 diabetes in Jimma Medical Center, Southwest Ethiopia.

Methods: This institution-based prospective observational study was conducted among 420 patients with type 2 diabetes at Jimma Medical Center's diabetic clinics. A pretested structured interviewer-administered questionnaire was used to collect data, and a checklist was used to assess patient documents. The data were analyzed using SPSS version 26. The variables linked to poor glycemic control were investigated using binary logistic regression. Variables with p values less than 0.05 were considered statistically significant.

Results: Six-month follow-ups were conducted among 420 patients with type 2 diabetes, among whom 220 (52.38%) were women. The median age of the participants was 54(IQR = 40-60 years old). The proportion of respondents with uncontrolled fasting blood glucose was 58.1%. Sex (AOR = 2.576, 95% CI [2.80-11.479], P = 0.001), age(≥ 60) (AOR = 2.024, 95% CI [1.794-4.646], P = 0.002), diabetes duration > 10 years (AOR = 3.036, 95% CI [2.616-8.306], P = 0.003), type 2 diabetes mellitus on insulin + oral antidiabetic (OADs) (AOR = 2.08, 95% CI [298-3.918], P = 0.004), obesity (AOR = 2.18, 95% CI [(1.218-4.218)], P = 0.003), diabetic complications (AOR = 3.193, 95% CI [2.324-6.05], p = 0.002) and poor self-care practices (AOR = 3.034, 95% CI [5.821-7.02], P = 0.005) were found to be significantly associated with poor glycemic control.

Conclusion: At the Jimma Medical Center, the prevalence of poor glycemic control was high. Based on these findings, teaching and counseling provided by healthcare providers should focus on improving diabetes self-care activities, weight reduction, and diabetic complications to achieve good glycemic control.

Clinical trial number: Not applicable.

背景:糖尿病是一种以高血糖和葡萄糖不耐受为特征的已知综合征,在世界范围内正以惊人的速度增加。全世界有超过5亿人患有糖尿病,其中大多数生活在低收入和中等收入国家。血糖控制不良是2型糖尿病患者的一个公共健康问题。血糖控制和识别与血糖控制不良相关的因素可以帮助医疗保健提供者设计方案,改善血糖控制和为患者提供的服务质量。目的:本研究旨在评估埃塞俄比亚西南部Jimma医疗中心2型糖尿病患者的血糖控制水平及相关因素。方法:本研究以机构为基础,对吉马医疗中心糖尿病门诊的420例2型糖尿病患者进行前瞻性观察研究。使用预先测试的结构化访谈者管理的问卷来收集数据,并使用检查表来评估患者文件。数据采用SPSS 26进行分析。使用二元逻辑回归研究与血糖控制不良相关的变量。p值小于0.05的变量被认为具有统计学意义。结果:420例2型糖尿病患者随访6个月,其中女性220例(52.38%)。参与者的中位年龄为54岁(IQR = 40-60岁)。受访者空腹血糖不控制的比例为58.1%。性(AOR = 2.576, 95% CI [2.80 - -11.479], P = 0.001),年龄(≥60岁)(优势比= 2.024,95% CI [1.794 - -4.646], P = 0.002),糖尿病病程> 10年(优势比= 3.036,95% CI [2.616 - -8.306], P = 0.003), 2型糖尿病胰岛素+口服抗糖尿病的(全尺寸)(优势比= 2.08,95% CI [298 - 3.918], P = 0.004),肥胖(优势比= 2.18,95% CI [(1.218 - -4.218)], P = 0.003),糖尿病并发症(优势比= 3.193,95% CI [2.324 - -6.05], P = 0.002)和不良的自我照顾行为(优势比= 3.034,95% CI (5.821 - -7.02),P = 0.005)与血糖控制不良显著相关。结论:吉马医疗中心血糖控制不良的发生率较高。基于这些发现,医疗保健提供者提供的教学和咨询应侧重于改善糖尿病自我保健活动、减轻体重和糖尿病并发症,以实现良好的血糖控制。临床试验号:不适用。
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引用次数: 0
The potential of insulin resistance indices to predict non-alcoholic fatty liver disease in patients with type 2 diabetes. 胰岛素抵抗指标预测2型糖尿病患者非酒精性脂肪性肝病的潜力
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-04 DOI: 10.1186/s12902-024-01794-z
Jie Tian, Yutian Cao, Wenhui Zhang, Aiyao Wang, Xinyi Yang, Yinfeng Dong, Xiqiao Zhou

Background: The triglyceride-glucose (TyG) index and related parameters, as well as the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), have been developed as insulin resistance markers to identify individuals at risk for non-alcoholic fatty liver disease (NAFLD). However, its use for predicting NAFLD in patients with type 2 diabetes mellitus (T2DM) remains unclear. In this study, we aimed to observe the performance of insulin resistance indices in diagnosing NAFLD combined with T2DM and to compare their diagnostic values in clinical practice.

Patients and methods: Overall, 268 patients with T2DM from the Endocrinology Department of Jiangsu Provincial Hospital of Traditional Chinese Medicine were enrolled in this study and divided into two groups: an NAFLD group (T2DM with NAFLD) and a T2DM group (T2DM without NAFLD). General information and blood indicators of the participants were collected, and insulin resistance indices were calculated based on these data. Receiver operating characteristic (ROC) analysis was conducted to calculate the area under the curve (AUC) for insulin resistance-related indices, aiming to assess their ability to discriminate between T2DM patients with and without NAFLD.

Results: ROC analysis revealed that among the five insulin resistance-related indices, four parameters (TyG, TyG-body mass index [BMI], TyG-waist circumference [WC], and TyG- (waist-hip ratio [WHR]) exhibited high predictive performance for identifying NAFLD, except for HOMA-IR (AUCs:0.710,0.738,0.737 and 0.730, respectivly). TyG-BMI demonstrated superior predictive value, especially in males. For males, the AUC for TyG-BMI was 0.764 (95% confidence interval [CI] 0.691-0.827). The sensitivity and specificity for male NAFLD were 90.32% and 47.89%, respectively. Moreover, in the Generalized linear regression models, there were positive associations of TyG, TyG-BMI, TyG-WC, TyG-WHR, and HOMA-IR with controlled attenuation parameter (CAP), with β values of 21.30, 0.745, 0.247, and 2.549 (all P < 0.001), respectively.

Conclusion: TyG-BMI is a promising predictor of NAFLD combined with T2DM, particularly in lean male patients.

背景:甘油三酯-葡萄糖(TyG)指数和相关参数,以及胰岛素抵抗稳态模型评估(HOMA-IR),已被开发为胰岛素抵抗标志物,以识别非酒精性脂肪性肝病(NAFLD)风险个体。然而,它在预测2型糖尿病(T2DM)患者NAFLD中的应用仍不清楚。在本研究中,我们旨在观察胰岛素抵抗指标在诊断NAFLD合并T2DM中的表现,并比较其在临床中的诊断价值。患者和方法:选取江苏省中医院内分泌科收治的T2DM患者268例,分为两组:NAFLD组(T2DM合并NAFLD)和T2DM组(T2DM无NAFLD)。收集参与者的一般信息和血液指标,并根据这些数据计算胰岛素抵抗指数。进行受试者工作特征(ROC)分析,计算胰岛素抵抗相关指标的曲线下面积(AUC),评估其区分T2DM合并与不合并NAFLD患者的能力。结果:ROC分析显示,5项胰岛素抵抗相关指标中,除HOMA-IR (auc分别为0.710、0.738、0.737、0.730)外,TyG、TyG体质指数(BMI)、TyG腰围(WC)、TyG腰臀比(WHR) 4项参数对NAFLD具有较高的预测能力。TyG-BMI表现出较好的预测价值,尤其是在男性中。对于男性,TyG-BMI的AUC为0.764(95%可信区间[CI] 0.691-0.827)。男性NAFLD的敏感性和特异性分别为90.32%和47.89%。此外,在广义线性回归模型中,TyG、TyG- bmi、TyG- wc、TyG- whr和HOMA-IR与控制衰减参数(CAP)呈正相关,其β值分别为21.30、0.745、0.247和2.549(均为P)。结论:TyG- bmi是NAFLD合并T2DM的一个有希望的预测因子,特别是在瘦男性患者中。
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引用次数: 0
Safety and efficacy of different basal insulin in type 2 diabetes mellitus with chronic kidney disease in Ramadan: prospective observational study. 斋月期间不同基础胰岛素治疗2型糖尿病合并慢性肾病的安全性和有效性:前瞻性观察研究
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-02 DOI: 10.1186/s12902-024-01778-z
Nur Haziqah Baharum, Sharifah Faradila Wan Muhammad Hatta, Nur Aisyah Zainordin, Rohana Abdul Ghani

Background: Diabetic kidney disease populations are categorized as high risk for fasting in Ramadan due to various potential fasting-related complications. Insulin analogues are recommended to be used in place of human insulin during fasting, as they carry a lower risk of hypoglycaemia and stable glycaemic variability. A paucity of data exits on the safety and efficacy of different basal insulin types during fasting for this population. This study aims to evaluate the safety and efficacy of three basal insulin among patients with Type 2 Diabetes Mellitus and concomitant mild to moderate chronic kidney disease who are keen to fast during Ramadan.

Materials and methods: A single-centered, prospective observational study was conducted among 46 patients with type 2 diabetes mellitus and concomitant chronic kidney disease stage 2 and 3 who were on three different types of basal insulin (Glargine U-100, Levemir, and Insulatard), fasted in Ramadan 2022. All variables were listed as median (IQR). Hypoglycaemia events and glycemic variability obtained from Freestyle Libre continuous glucose monitoring were compared between insulin groups. Changes in glycated haemoglobin, fasting plasma glucose, renal profile, body weight, body mass index, and waist circumference pre and post-Ramadan were evaluated.

Results: The glycaemic variability was found highest in Insulatard with a median (IQR) of 37.2(33)% versus Levemir 34.4(32.4)% versus Glargine U-100 36.8(30.6)%, p = NS. Levemir had reported the lowest median time of below range of 2.5(13)% followed by Glargine 4(25)% and Insulatard 5(8)%; p = NS. The findings of this study indicated that glycated haemoglobin, fasting plasma glucose, renal profile, body weight, body mass index, and waist circumference did not alter statistically between the three groups post-Ramadan. Individually, Insulatard showed a significant reduction in weight and waist circumference (0.9kg, p = 0.026; 0.44 cm, p = 0.008) while Levemir showed a reduction in waist circumference (0.75cm, p = 0.019).

Conclusion: This study revealed that Insulatard, Levemir, and Glargine demonstrated similar levels of safety and efficacy among those with diabetic kidney disease who observed fasting during Ramadan.

背景:由于各种潜在的与禁食相关的并发症,糖尿病肾病人群被归类为斋月禁食的高风险人群。建议在禁食期间使用胰岛素类似物代替人胰岛素,因为它们低血糖的风险较低,血糖变异性稳定。缺乏关于不同基础胰岛素类型在该人群禁食期间的安全性和有效性的数据。本研究旨在评估三种基础胰岛素在2型糖尿病合并轻中度慢性肾病患者斋月期间热衷于禁食的安全性和有效性。材料和方法:对46例2型糖尿病合并慢性肾脏疾病2期和3期患者进行了一项单中心前瞻性观察研究,这些患者在2022年斋月禁食,使用三种不同类型的基础胰岛素(甘精U-100、Levemir和Insulatard)。所有变量均以中位数(IQR)列示。通过Freestyle Libre连续血糖监测获得的低血糖事件和血糖变异性在胰岛素组之间进行比较。评估斋月前后糖化血红蛋白、空腹血糖、肾功能、体重、体重指数和腰围的变化。结果:Insulatard组血糖变异性最高,中位数(IQR)为37.2(33)%,Levemir组为34.4(32.4)%,甘精U-100组为36.8(30.6)%,p = NS。Levemir报告的中位低于范围时间最低为2.5(13)%,其次是甘精4(25)%和Insulatard 5(8)%;p = NS。本研究的结果表明,在斋月后,三组之间的糖化血红蛋白、空腹血糖、肾谱、体重、体重指数和腰围在统计学上没有改变。单独来看,Insulatard显示体重和腰围显著减少(0.9kg, p = 0.026;0.44 cm, p = 0.008),而Levemir显示腰围减少(0.75cm, p = 0.019)。结论:本研究表明,在斋月期间禁食的糖尿病肾病患者中,Insulatard、Levemir和甘精显示出相似的安全性和有效性。
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引用次数: 0
Cognitive changes in people with diabetes with lower extremity complications compared to people with diabetes without lower extremity complications: a systematic review and meta-analysis. 伴有下肢并发症的糖尿病患者与无下肢并发症的糖尿病患者的认知变化:一项系统回顾和荟萃分析
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-29 DOI: 10.1186/s12902-024-01774-3
Nimantha Karunathilaka, Christina Parker, Peter A Lazzarini, Pamela Chen, Chloe Katsanos, Margaret MacAndrew, Kathleen Finlayson

Background: Recent evidence suggests that diabetes-related lower-extremity complications (DRLECs) may be associated with cognitive changes in people with diabetes. However, existing literature has produced inconsistent findings, and no systematic reviews have been conducted to investigate whether DRLECs impact the cognition of people with diabetes. This systematic review evaluated existing studies that investigated cognition in people with diabetes with DRLECs and without DRLECs.

Method: Seven databases; MEDLINE, PubMed, CINAHL, EMBASE, Cochrane, PsycINFO and Web of Science were searched from inception until 22/8/2022 for studies that compared cognition in people with diabetes with and without DRLECs. Results were independently screened for eligibility and assessed for methodological quality by two authors, with key data extracted. Studies were eligible for meta-analysis if the studies reported similar cases, controls, and outcome measures.

Results: Thirteen studies were included in the review, with eleven of medium methodological quality, one of high quality, and one of low quality. Four studies found significant differences in cognition between those with and without DRLECs, four found significant associations between diabetes-related lower-extremity complications and cognition, and five found no differences or associations. One small meta-analysis of eligible studies found that there was no statistically significant difference in cognition in people without, compared to with, peripheral neuropathy (Mean difference = -0.49; 95%CI: -1.59-0.61; N = 3; n = 215). Leave-one-out sensitivity analyses further confirmed that there was no significant difference in cognition among people with and without peripheral neuropathy (p > 0.05).

Conclusion: DRLECs may be related to cognition in people with diabetes, however, existing evidence is unclear due to variability in used methodologies that may challenge concluding the findings. Future high-quality studies investigating cognition among people with and without DRLECs are needed.

背景:最近的证据表明,糖尿病相关的下肢并发症(DRLECs)可能与糖尿病患者的认知变化有关。然而,现有文献得出了不一致的结果,并且没有进行系统的综述来调查DRLECs是否影响糖尿病患者的认知。本系统综述评估了现有的研究,这些研究调查了伴有和不伴有drlec的糖尿病患者的认知能力。方法:7个数据库;我们检索了MEDLINE、PubMed、CINAHL、EMBASE、Cochrane、PsycINFO和Web of Science从成立到2022年8月22日的研究,以比较患有和不患有DRLECs的糖尿病患者的认知能力。结果由两位作者独立筛选合格性和方法学质量评估,并提取关键数据。如果研究报告了相似的病例、对照和结果测量,则有资格进行荟萃分析。结果:本综述纳入13项研究,其中11项方法学质量中等,1项高质量,1项低质量。四项研究发现,有和没有drlec的人在认知方面存在显著差异,四项研究发现糖尿病相关下肢并发症与认知之间存在显著关联,五项研究发现没有差异或关联。一项对符合条件的研究进行的小型荟萃分析发现,与周围神经病变患者相比,没有周围神经病变患者的认知能力没有统计学上的显著差异(平均差异= -0.49;95%置信区间:-1.59—-0.61;n = 3;n = 215)。留一敏感性分析进一步证实,周围神经病变患者和非周围神经病变患者的认知能力无显著差异(p < 0.05)。结论:DRLECs可能与糖尿病患者的认知有关,然而,由于使用方法的差异,现有证据尚不清楚,这可能会对结论提出质疑。未来需要高质量的研究来调查有或没有drlec的人的认知。
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引用次数: 0
The relationship of dietary omega-3 fatty acid and omega-6 to omega-3 ratio intake and likelihood of type 2 diabetes in a cross-sectional study. 在一项横断面研究中,饮食中omega-3脂肪酸和omega-6与omega-3比值摄入与2型糖尿病可能性的关系
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-29 DOI: 10.1186/s12902-024-01787-y
Ebrahim Shakiba, Yahya Pasdar, Farzaneh Asoudeh, Farid Najafi, Amir Saber, Mohammad Hossein Shakiba, Amir Bagheri

Background: There is a belief that consuming a significant amount of omega-3 and omega-6 fatty acids can positively affect chronic diseases. However, the connection between these fatty acids and type 2 diabetes mellitus (T2DM) risk remains unclear. To explore this further, we conducted a study to investigate the relationship between dietary intake of omega-3 and omega-6 fatty acids (FA), as well as omega-6 to omega-3 ratio, and the odds of T2DM.

Methods: Our research involved a cross-sectional analysis of data from the Ravansar Non-Communicable Disease (RaNCD) cohort. We evaluated their dietary habits using a comprehensive 118-item food frequency questionnaire (FFQ). To determine the aforementioned association, we employed logistic regression analysis to calculate odds ratios (OR) and 95% confidence intervals (CIs).

Results: The prevalence of T2DM among 8744 qualified participants was 751 (8.6%). After considering all the possible factors that could affect the outcome, high dietary omega-3 intake was associated with a 58% lower likelihood of T2DM (OR: 0.42; 95% CI: 0.32, 0.56; P-trend: <0.001). In contrast, participants at the fourth quartile of the dietary omega 6 to omega 3 FA ratio had a higher odd of T2DM (OR: 1.42; 95%CI: 1.11, 1.84; P-trend: 0.01). Nevertheless, there was no significant connection between the highest and lowest quartile of dietary omega-6 intake (OR: 0.91; 95% CI: 0.71, 1.17; P-trend: 0.80).

Conclusion: According to the study, consuming omega-3 fatty acids through diet was linked with lower odds of type 2 diabetes. Conversely, an elevated omega-6 to omega-3 ratio was associated with a greater likelihood of T2DM.

背景:有一种观点认为,摄入大量的omega-3和omega-6脂肪酸对慢性疾病有积极的影响。然而,这些脂肪酸与2型糖尿病(T2DM)风险之间的关系尚不清楚。为了进一步探讨这一点,我们进行了一项研究,调查饮食中摄入omega-3和omega-6脂肪酸(FA)以及omega-6与omega-3的比例与2型糖尿病发病率之间的关系。方法:我们的研究涉及Ravansar非传染性疾病(randd)队列数据的横断面分析。我们使用一份包含118个项目的食物频率问卷(FFQ)来评估他们的饮食习惯。为了确定上述关联,我们采用逻辑回归分析来计算优势比(OR)和95%置信区间(ci)。结果:8744名合格受试者中T2DM患病率为751(8.6%)。在考虑了所有可能影响结果的因素后,高饮食摄入omega-3与T2DM的可能性降低58%相关(OR: 0.42;95% ci: 0.32, 0.56;结论:根据这项研究,通过饮食摄入omega-3脂肪酸可以降低患2型糖尿病的几率。相反,omega-6与omega-3比值升高与2型糖尿病的可能性增加有关。
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引用次数: 0
Metabolic syndrome in association with novel dietary index, metabolic parameters, nesfatin-1 and omentin-1. 代谢综合征与新型膳食指数、代谢参数、nesfatin-1 和 omentin-1 的关系。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-27 DOI: 10.1186/s12902-024-01791-2
Houshang Bavandpour Karvane, Haleh Esfandiari, Omer Qutaiba, B Allela, Morug Salih Mahdi, Ali M Ali Al-Nuaimi, Rouaida Kadhim A Al-Hussein, Mahmood Jasem Jawad, Arman Ghayourvahdat, Ali Keshavarzian

Background: Metabolic syndrome is a prevalent and common health problem and numerous studies have revealed the role of diet and lifestyle change in prevention of metabolic syndrome. However, the novel dietary index, cardioprotective index (CPI) and its association with metabolic syndrome is not investigated yet. In the current study, we evaluated the association between metabolic syndrome and its components, CPI, Nesfatin-1 and Omentin-1in a cross-sectional study.

Methods: Three hundred forty eight overweight and obese individuals with metabolic syndrome were recruited. Subjects underwent anthropometric and laboratory assays including metabolic markers, Nesfatin-1 and Omentin-1 with commercial kits.

Results: Those at the first tertile of CPI had lower high density lipoprotein concentrations (HDL) and higher low density lipoprotein concentrations (LDL), triglyceride (TG), systolic and diastolic blood pressures (SBP, DBP) levels compared with those at the highest tertiles (P < 0.05). After adjustment for the confounding effects of age, sex, body mass index, physical activity and total calorie intake, LDL lost its significance across CPI tertiles. Moreover, serum total cholesterol, insulin and insulin resistance were not significant across CPI tertiles neither in crude nor in adjusted models (P > 0.05). Additionally, being at the third tertile of CPI was accompanied with significantly higher Nesfatin-1 and Omentin-1 levels compared with lowest tertiels (P < 0.05) in crude and confounder - adjusted models.

Conclusions: To our findings, CPI was in positive relationship with metabolic parameters, blood pressure, Nesfatin-1 and Omentin-1 levels in metabolic syndrome. Further future studies will help to elaborate the causality.

Clinical trial number: Not applicable.

背景:代谢综合征是一种普遍存在的常见健康问题,许多研究揭示了饮食和生活方式的改变在预防代谢综合征中的作用。然而,新型膳食指数--心脏保护指数(CPI)及其与代谢综合征的关系尚未得到研究。在本研究中,我们在一项横断面研究中评估了代谢综合征与其成分 CPI、Nesfatin-1 和 Omentin-1 之间的关系:方法:我们招募了 348 名超重和肥胖的代谢综合征患者。受试者接受了人体测量和实验室检测,包括使用商业试剂盒检测代谢指标、Nesfatin-1 和 Omentin-1:结果:与最高三分位数的人相比,CPI 第一分位数的人高密度脂蛋白浓度(HDL)较低,低密度脂蛋白浓度(LDL)、甘油三酯(TG)、收缩压和舒张压(SBP、DBP)水平较高(P 0.05)。此外,与最低三分位数相比,CPI 第三三分位数的 Nesfatin-1 和 Omentin-1 水平明显更高(P 0.05):根据我们的研究结果,CPI 与代谢综合征患者的代谢参数、血压、Nesfatin-1 和 Omentin-1 水平呈正相关。未来的进一步研究将有助于阐明其中的因果关系:不适用。
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引用次数: 0
Systemic immune-inflammatory index predicts fragility fracture risk in postmenopausal anemic females with type 2 diabetes mellitus: evidence from a longitudinal cohort study. 全身免疫炎症指数可预测绝经后贫血女性 2 型糖尿病患者发生脆性骨折的风险:一项纵向队列研究提供的证据。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-27 DOI: 10.1186/s12902-024-01792-1
Dinggui Huang, Qi He, Jiangmei Pan, Zhenwei Zhai, Jingxia Sun, Qiu Wang, Wenxin Chu, Jianhao Huang, Jinming Yu, Xiaoqin Qiu, Wensheng Lu

Background: Chronic low-grade inflammation is related to bone metabolism in patients with type 2 diabetes mellitus (T2DM). However, credible data indicating the relationship between inflammation and fragility fracture risk in postmenopausal anemic females with T2DM are sparse. The current study sought to investigate the relationships between the systemic immune-inflammatory index (SII) and fragility fracture events, as well as the future 10-year fragility fracture probability evaluated using the fracture risk assessment tool (FRAX) in postmenopausal females with T2DM.

Methods: According to the tertiles of SII, 423 postmenopausal females with T2DM were divided into three groups: low-level (≤ 381.32, n = 141), moderate-level (381.32-629.46, n = 141), and high-level (≥ 629.46, n = 141). All participants were followed up for 7 years with a median of 46.8 months (1651 person-years). The association between SII and fragility fracture risk was assessed.

Results: Of 423 subjects, 75 experienced a fragility fracture event. Spearman partial correlation analysis revealed that SII was negatively related to bone mineral density (BMD) and was positively associated with the future 10-year probability of major osteoporotic fracture (MOF) and hip fracture (HF). Restricted cubic spline (RCS) analysis revealed a positive correlation between SII and fragility fracture risk in an approximately inverted J-shaped dose-response pattern (P for overall < 0.0001). Multivariate Cox regression analysis demonstrated that patients with a high SII presented a greater risk of fragility fractures (P = 0.011). Stratified analysis revealed that fragility fractures in the high-level SII were predominantly associated with anemia with an increase of 4.15 times (P = 0.01). Kaplan‒Meier analysis indicated a greater cumulative incidence of fragility fractures in patients with a high SII (log-rank, all P = 0.0012). Receiver operating characteristic (ROC) analysis indicated an optimal SII cut-off value of 537.34, with an area under the curve (AUC) of 0.646, a sensitivity of 60%, and a specificity of 64.1% (P < 0.001).

Conclusion: The SII revealed a significant positive association with a real-world fragility fracture event and a future 10-year fragility fracture probability in postmenopausal females with T2DM, particularly evident in individuals with anemia. Therefore, monitoring the SII and hemoglobin in postmenopausal older women with T2DM is helpful in routine clinical practice to identify individuals at high risk for fragility fractures and to promptly execute appropriate fracture intervention procedures.

背景:慢性低度炎症与 2 型糖尿病(T2DM)患者的骨代谢有关。然而,关于绝经后贫血女性 T2DM 患者炎症与脆性骨折风险之间关系的可靠数据却很少。本研究旨在探讨全身免疫炎症指数(SII)与脆性骨折事件之间的关系,以及使用骨折风险评估工具(FRAX)评估绝经后女性 T2DM 患者未来 10 年脆性骨折概率:根据SII的分层,将423名T2DM绝经后女性分为三组:低水平组(≤ 381.32,n = 141)、中水平组(381.32-629.46,n = 141)和高水平组(≥ 629.46,n = 141)。所有参与者的随访时间均为 7 年,中位数为 46.8 个月(1651 人年)。评估了 SII 与脆性骨折风险之间的关联:结果:在 423 名受试者中,75 人发生了脆性骨折。斯皮尔曼偏相关分析显示,SII与骨矿物质密度(BMD)呈负相关,与未来10年发生重大骨质疏松性骨折(MOF)和髋部骨折(HF)的概率呈正相关。受限立方样条曲线(RCS)分析显示,SII与脆性骨折风险呈近似倒 "J "形的剂量-反应模式正相关(P为总体结论):在患有 T2DM 的绝经后女性中,SII 与实际发生的脆性骨折事件和未来 10 年的脆性骨折概率呈显著正相关,这一点在贫血患者中尤为明显。因此,在常规临床实践中,对患有 T2DM 的绝经后老年女性进行 SII 和血红蛋白监测有助于识别脆性骨折高危人群,并及时采取适当的骨折干预措施。
{"title":"Systemic immune-inflammatory index predicts fragility fracture risk in postmenopausal anemic females with type 2 diabetes mellitus: evidence from a longitudinal cohort study.","authors":"Dinggui Huang, Qi He, Jiangmei Pan, Zhenwei Zhai, Jingxia Sun, Qiu Wang, Wenxin Chu, Jianhao Huang, Jinming Yu, Xiaoqin Qiu, Wensheng Lu","doi":"10.1186/s12902-024-01792-1","DOIUrl":"10.1186/s12902-024-01792-1","url":null,"abstract":"<p><strong>Background: </strong>Chronic low-grade inflammation is related to bone metabolism in patients with type 2 diabetes mellitus (T2DM). However, credible data indicating the relationship between inflammation and fragility fracture risk in postmenopausal anemic females with T2DM are sparse. The current study sought to investigate the relationships between the systemic immune-inflammatory index (SII) and fragility fracture events, as well as the future 10-year fragility fracture probability evaluated using the fracture risk assessment tool (FRAX) in postmenopausal females with T2DM.</p><p><strong>Methods: </strong>According to the tertiles of SII, 423 postmenopausal females with T2DM were divided into three groups: low-level (≤ 381.32, n = 141), moderate-level (381.32-629.46, n = 141), and high-level (≥ 629.46, n = 141). All participants were followed up for 7 years with a median of 46.8 months (1651 person-years). The association between SII and fragility fracture risk was assessed.</p><p><strong>Results: </strong>Of 423 subjects, 75 experienced a fragility fracture event. Spearman partial correlation analysis revealed that SII was negatively related to bone mineral density (BMD) and was positively associated with the future 10-year probability of major osteoporotic fracture (MOF) and hip fracture (HF). Restricted cubic spline (RCS) analysis revealed a positive correlation between SII and fragility fracture risk in an approximately inverted J-shaped dose-response pattern (P for overall < 0.0001). Multivariate Cox regression analysis demonstrated that patients with a high SII presented a greater risk of fragility fractures (P = 0.011). Stratified analysis revealed that fragility fractures in the high-level SII were predominantly associated with anemia with an increase of 4.15 times (P = 0.01). Kaplan‒Meier analysis indicated a greater cumulative incidence of fragility fractures in patients with a high SII (log-rank, all P = 0.0012). Receiver operating characteristic (ROC) analysis indicated an optimal SII cut-off value of 537.34, with an area under the curve (AUC) of 0.646, a sensitivity of 60%, and a specificity of 64.1% (P < 0.001).</p><p><strong>Conclusion: </strong>The SII revealed a significant positive association with a real-world fragility fracture event and a future 10-year fragility fracture probability in postmenopausal females with T2DM, particularly evident in individuals with anemia. Therefore, monitoring the SII and hemoglobin in postmenopausal older women with T2DM is helpful in routine clinical practice to identify individuals at high risk for fragility fractures and to promptly execute appropriate fracture intervention procedures.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"256"},"PeriodicalIF":2.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p. 更正:PIWIL2 通过与 miR-146a-3p 相互作用抑制甲状腺癌的进展。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-26 DOI: 10.1186/s12902-024-01786-z
Xiaoxiao Lu, Qingyun Zhu, Hong Du, Mingjun Gu, Xiangqi Li
{"title":"Correction: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p.","authors":"Xiaoxiao Lu, Qingyun Zhu, Hong Du, Mingjun Gu, Xiangqi Li","doi":"10.1186/s12902-024-01786-z","DOIUrl":"10.1186/s12902-024-01786-z","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"255"},"PeriodicalIF":2.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance. 肥胖与多囊卵巢综合症患者的 SHBG 水平有关,而不是与胰岛素抵抗的血脂状况有关。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-25 DOI: 10.1186/s12902-024-01789-w
Haolin Zhang, Weiyu Qiu, Ping Zhou, Li Shi, Ziting Chen, Yang Yang, Yonghao Lu, Lifei Zhou, Hua Zhang, Ming Cheng, Yang Ye, Rong Li

Objective: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present concurrently. Nevertheless, the correlation between obesity, sex hormone levels, and blood lipid profiles in PCOS patients with IR remains uncertain.

Methods: This is a cross-sectional study including a total of 206 Chinese women diagnosed with PCOS, enrolled between March 2016 and December 2021. The participants' anthropometric measurements, such as weight, height, waist circumference, and hip circumference, were recorded. Additionally, fasting blood samples were collected to measure various parameters, including fasting glucose, insulin levels, lipid profiles, and sex hormone levels.

Results: Our findings highlight that obesity exhibited a significant correlation with lower levels of sex hormone binding globulin (SHBG) and elevated levels of free androgen index (FAI), fasting insulin, and HOMA-IR in PCOS patients diagnosed with IR. However, no significant association between obesity and blood lipid profiles was observed within this particular group of women.

Conclusion: This study suggests that among PCOS patients with IR, lower levels of SHBG and higher levels of FAI are associated with obesity. These findings indicate that SHBG and FAI may have the potential to serve as a biomarker for the initial identification and prognosis of IR in PCOS patients.

Trial registration: Retrospectively registered on 25/04/2020 at ClinicalTrials.gov Identifer: NCT04264832.

目的:多囊卵巢综合征(PCOS)是一种常见的内分泌疾病,其特点是内分泌失调和胰岛素抵抗(IR)。在与多囊卵巢综合征相关的代谢异常中,肥胖往往同时存在。然而,多囊卵巢综合症患者的肥胖、性激素水平和血脂谱之间的相关性仍不确定:这是一项横断面研究,共纳入 206 名确诊为多囊卵巢综合征的中国女性,入组时间为 2016 年 3 月至 2021 年 12 月。研究记录了参与者的人体测量数据,如体重、身高、腰围和臀围。此外,还采集了空腹血样以测量各种参数,包括空腹血糖、胰岛素水平、血脂概况和性激素水平:我们的研究结果表明,肥胖与性激素结合球蛋白(SHBG)水平降低以及游离雄激素指数(FAI)、空腹胰岛素和 HOMA-IR 水平升高有显著相关性。然而,在这一特殊女性群体中,并未观察到肥胖与血脂谱之间存在明显关联:本研究表明,在患有 IR 的 PCOS 患者中,较低水平的 SHBG 和较高水平的 FAI 与肥胖有关。这些研究结果表明,SHBG 和 FAI 有可能成为 PCOS 患者 IR 的初步识别和预后的生物标志物:回顾性注册:2020年4月25日在ClinicalTrials.gov Identifer:NCT04264832注册。
{"title":"Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance.","authors":"Haolin Zhang, Weiyu Qiu, Ping Zhou, Li Shi, Ziting Chen, Yang Yang, Yonghao Lu, Lifei Zhou, Hua Zhang, Ming Cheng, Yang Ye, Rong Li","doi":"10.1186/s12902-024-01789-w","DOIUrl":"10.1186/s12902-024-01789-w","url":null,"abstract":"<p><strong>Objective: </strong>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present concurrently. Nevertheless, the correlation between obesity, sex hormone levels, and blood lipid profiles in PCOS patients with IR remains uncertain.</p><p><strong>Methods: </strong>This is a cross-sectional study including a total of 206 Chinese women diagnosed with PCOS, enrolled between March 2016 and December 2021. The participants' anthropometric measurements, such as weight, height, waist circumference, and hip circumference, were recorded. Additionally, fasting blood samples were collected to measure various parameters, including fasting glucose, insulin levels, lipid profiles, and sex hormone levels.</p><p><strong>Results: </strong>Our findings highlight that obesity exhibited a significant correlation with lower levels of sex hormone binding globulin (SHBG) and elevated levels of free androgen index (FAI), fasting insulin, and HOMA-IR in PCOS patients diagnosed with IR. However, no significant association between obesity and blood lipid profiles was observed within this particular group of women.</p><p><strong>Conclusion: </strong>This study suggests that among PCOS patients with IR, lower levels of SHBG and higher levels of FAI are associated with obesity. These findings indicate that SHBG and FAI may have the potential to serve as a biomarker for the initial identification and prognosis of IR in PCOS patients.</p><p><strong>Trial registration: </strong>Retrospectively registered on 25/04/2020 at ClinicalTrials.gov Identifer: NCT04264832.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"254"},"PeriodicalIF":2.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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BMC Endocrine Disorders
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