首页 > 最新文献

BMC Endocrine Disorders最新文献

英文 中文
The effects of supervised aerobic training on dyslipidaemia among diabetic older patients. 有监督的有氧训练对老年糖尿病患者血脂异常的影响。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-09 DOI: 10.1186/s12902-024-01745-8
Ahmad H Alghadir, Sami A Gabr, Amir Iqbal
<p><strong>Background: </strong>Higher prevalence rates of diabetes and its complications have been reported among individuals with poor physical activity and a sedentary lifestyle. This study explored the influence of six months of moderate-intensity supervised aerobic training on the serum lipid profile, hs-CRP level, and variable-related correlations in prediabetic and type 2 diabetes patients (T2DM).</p><p><strong>Design: </strong>The study was based on a two-arm parallel group pretest‒posttest comparative design.</p><p><strong>Methods: </strong>A total of 50 subjects who were diagnosed with diabetes for more than five years and aged 30-70 years were included in this study. The subjects were classified into two groups on the basis of their glycated haemoglobin (HbA1c%) values: Group 1 (patients with the prediabetes; HbA1c % ≤ 6.5, n = 25) and Group 2 (patients with the T2DM; HbA1c % ≥ 6.5, n = 25). Blood sugar, HbA1c %, insulin, lipid profile, and highly sensitive CRP (hs-CRP) were measured via colorimetric and immunoassay techniques at baseline and six months postintervention with moderate aerobic exercise.</p><p><strong>Results: </strong>The results revealed that participation in moderate aerobic training interventions for six months resulted in a significant reduction in BMI, fasting blood sugar, glycosylated haemoglobin, hs-CRP, and lipid profile parameters such as T-Cholest, TG, and LDL-C as well as significant improvement in the level of insulin with a reduction in the values of HOMA-IR towards normal values in the patients with prediabetes (P < 0.01) in group 1 and patients with diabetes in group 2 (P < 0.001). The change in VO<sub>2</sub>max with good physical fitness significantly improved with the exercise program after six months. The reduced levels of hs-CRP, HOMA-IR, and lipid profile and improved levels of insulin were significantly positively correlated with the levels of glycated haemoglobin (HbA1c%) in the patients with prediabetes (P < 0.01) and those with diabetes (P < 0.001) following six months of moderate aerobic training interventions. Moreover, hs-CRP was positively correlated with T-Cholest, TG, and LDL-C (p = 0.01) and negatively correlated with HDL-C. The data revealed improved glycemic control factors, lipid profiles, and hs-CRP levels as cardio-predictive markers in patients with both prediabetes and diabetes as well. These findings suggest that the anti-inflammatory effect of physical activity gained from moderate exercise training for six months may counteract increased cardiovascular complications associated with increased CRP levels and lipid profiles in prediabetes and T2DM patients.</p><p><strong>Conclusions: </strong>Moderate aerobic training for six months favourably affects glycemic parameters, lipid profiles, and inflammatory hs-CRP indicators and improves VO<sub>2</sub>max, an indicator of physical fitness, in prediabetic and diabetic patients. The data obtained suggest the positive effect of moderate e
背景:据报道,体力活动少和久坐不动的人患糖尿病及其并发症的比例较高。本研究探讨了为期 6 个月的中等强度有氧训练对糖尿病前期和 2 型糖尿病患者(T2DM)血清脂质概况、hs-CRP 水平和变量相关性的影响:研究采用两臂平行分组前测-后测对比设计:本研究共纳入 50 名确诊糖尿病五年以上、年龄在 30-70 岁之间的受试者。根据糖化血红蛋白(HbA1c%)值将受试者分为两组:第 1 组(糖尿病前期患者;HbA1c ≤ 6.5,n = 25)和第 2 组(T2DM 患者;HbA1c ≥ 6.5,n = 25)。通过比色法和免疫测定法对基线血糖、HbA1c %、胰岛素、血脂和高敏 CRP(hs-CRP)进行测量,并在干预后六个月进行适度有氧运动:结果表明,参加为期六个月的中等强度有氧运动训练干预后,糖尿病前期患者的体重指数、空腹血糖、糖化血红蛋白、高敏CRP、血脂指标(如胆固醇、总胆固醇和低密度脂蛋白胆固醇)均显著降低,胰岛素水平也有明显改善,HOMA-IR值也向正常值降低(P 2max)。糖尿病前期患者的 hs-CRP、HOMA-IR 和血脂水平的降低以及胰岛素水平的改善与糖化血红蛋白(HbA1c%)水平呈显著正相关(P 结论:糖尿病前期患者的 Hs-CRP、HOMA-IR 和血脂水平的降低以及胰岛素水平的改善与糖化血红蛋白(HbA1c%)水平呈显著正相关:为期六个月的适度有氧训练对糖尿病前期和糖尿病患者的血糖参数、血脂概况和炎症性 hs-CRP 指标产生了有利影响,并提高了体能指标 VO2max。获得的数据表明,适度的运动训练对糖尿病前期和 T2DM 患者的心血管疾病,包括血脂异常、血糖控制和 hs-CRP 炎症指标具有积极的保护调节作用。因此,定期锻炼具有抗炎作用,能改善心肺功能、血脂状况、血糖水平和胰岛素抵抗,有助于减轻糖尿病前期、T2DM 患者和健康对照组心血管疾病的严重程度:试验注册:已在 ClinicalTrials.gov PRS 上进行了回顾性注册,试验标识符 ID:NCT06246435:NCT06246435,日期为 2024 年 1 月 30 日。
{"title":"The effects of supervised aerobic training on dyslipidaemia among diabetic older patients.","authors":"Ahmad H Alghadir, Sami A Gabr, Amir Iqbal","doi":"10.1186/s12902-024-01745-8","DOIUrl":"10.1186/s12902-024-01745-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Higher prevalence rates of diabetes and its complications have been reported among individuals with poor physical activity and a sedentary lifestyle. This study explored the influence of six months of moderate-intensity supervised aerobic training on the serum lipid profile, hs-CRP level, and variable-related correlations in prediabetic and type 2 diabetes patients (T2DM).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;The study was based on a two-arm parallel group pretest‒posttest comparative design.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 50 subjects who were diagnosed with diabetes for more than five years and aged 30-70 years were included in this study. The subjects were classified into two groups on the basis of their glycated haemoglobin (HbA1c%) values: Group 1 (patients with the prediabetes; HbA1c % ≤ 6.5, n = 25) and Group 2 (patients with the T2DM; HbA1c % ≥ 6.5, n = 25). Blood sugar, HbA1c %, insulin, lipid profile, and highly sensitive CRP (hs-CRP) were measured via colorimetric and immunoassay techniques at baseline and six months postintervention with moderate aerobic exercise.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The results revealed that participation in moderate aerobic training interventions for six months resulted in a significant reduction in BMI, fasting blood sugar, glycosylated haemoglobin, hs-CRP, and lipid profile parameters such as T-Cholest, TG, and LDL-C as well as significant improvement in the level of insulin with a reduction in the values of HOMA-IR towards normal values in the patients with prediabetes (P &lt; 0.01) in group 1 and patients with diabetes in group 2 (P &lt; 0.001). The change in VO&lt;sub&gt;2&lt;/sub&gt;max with good physical fitness significantly improved with the exercise program after six months. The reduced levels of hs-CRP, HOMA-IR, and lipid profile and improved levels of insulin were significantly positively correlated with the levels of glycated haemoglobin (HbA1c%) in the patients with prediabetes (P &lt; 0.01) and those with diabetes (P &lt; 0.001) following six months of moderate aerobic training interventions. Moreover, hs-CRP was positively correlated with T-Cholest, TG, and LDL-C (p = 0.01) and negatively correlated with HDL-C. The data revealed improved glycemic control factors, lipid profiles, and hs-CRP levels as cardio-predictive markers in patients with both prediabetes and diabetes as well. These findings suggest that the anti-inflammatory effect of physical activity gained from moderate exercise training for six months may counteract increased cardiovascular complications associated with increased CRP levels and lipid profiles in prediabetes and T2DM patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Moderate aerobic training for six months favourably affects glycemic parameters, lipid profiles, and inflammatory hs-CRP indicators and improves VO&lt;sub&gt;2&lt;/sub&gt;max, an indicator of physical fitness, in prediabetic and diabetic patients. The data obtained suggest the positive effect of moderate e","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"212"},"PeriodicalIF":2.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arginine vasopressin deficiency (central diabetes insipidus) with partial empty sella: a case report. 精氨酸加压素缺乏症(中枢性糖尿病)伴部分蝶鞍空虚:病例报告。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-08 DOI: 10.1186/s12902-024-01741-y
Kibret Enyew Belay, Rebil H Jemal, Ayele H Kebede, Meron G Tulu, Alamirew Enyew Belay, Asteway Mulat Haile, Samuel A Demisse

Background: Arginine vasopressin deficiency (central diabetes insipidus) is defined as a reduction in the release of arginine vasopressin (AVP) resulting in a variable degree of polyuria. Partial empty sella refers to an enlarged sella turcica that is not completely filled by pituitary gland. It can be either primary or secondary and its manifestation ranges from asymptomatic cases to isolated posterior pituitary, isolated anterior pituitary or both anterior and posterior pituitary dysfunctions. Diabetes insipidus caused by a partially empty sella is rare.

Case presentation: The patient, an 18-year-old Ethiopian woman who presented with long standing headache, increased urination, increased thirst, absence of menses and weight loss. Urine and serum osmolality was done and suggested diabetes insipidus. On further workup, brain magnetic resonant imaging was done and partially empty sella was diagnosed.

Conclusion: Diabetes insipidus secondary to partially empty sella is uncommon. In patients presenting with headache and anterior or posterior pituitary dysfunction, empty sella should be considered, whether partial or complete.

背景:精氨酸加压素缺乏症(中枢性糖尿病)是指精氨酸加压素(AVP)释放减少,导致不同程度的多尿。部分空蝶鞍指的是脑垂体未完全充盈的肿大蝶鞍。它既可以是原发性的,也可以是继发性的,其表现范围从无症状病例到孤立的垂体后叶、孤立的垂体前叶或垂体前后叶功能障碍。因蝶鞍部分空虚而导致的糖尿病性尿崩症非常罕见:患者是一名 18 岁的埃塞俄比亚女性,因长期头痛、排尿增多、口渴、无月经和体重减轻而就诊。尿液和血清渗透压检查结果显示她患有糖尿病。进一步检查后,做了脑磁共振成像,诊断为部分空蝶鞍:结论:继发于部分脑脊膜空洞的糖尿病性尿崩症并不常见。结论:继发于部分脑蝶鞍空洞的糖尿病性血脂症并不常见,对于出现头痛、垂体前叶或后叶功能障碍的患者,应考虑脑蝶鞍部分或完全空洞。
{"title":"Arginine vasopressin deficiency (central diabetes insipidus) with partial empty sella: a case report.","authors":"Kibret Enyew Belay, Rebil H Jemal, Ayele H Kebede, Meron G Tulu, Alamirew Enyew Belay, Asteway Mulat Haile, Samuel A Demisse","doi":"10.1186/s12902-024-01741-y","DOIUrl":"10.1186/s12902-024-01741-y","url":null,"abstract":"<p><strong>Background: </strong>Arginine vasopressin deficiency (central diabetes insipidus) is defined as a reduction in the release of arginine vasopressin (AVP) resulting in a variable degree of polyuria. Partial empty sella refers to an enlarged sella turcica that is not completely filled by pituitary gland. It can be either primary or secondary and its manifestation ranges from asymptomatic cases to isolated posterior pituitary, isolated anterior pituitary or both anterior and posterior pituitary dysfunctions. Diabetes insipidus caused by a partially empty sella is rare.</p><p><strong>Case presentation: </strong>The patient, an 18-year-old Ethiopian woman who presented with long standing headache, increased urination, increased thirst, absence of menses and weight loss. Urine and serum osmolality was done and suggested diabetes insipidus. On further workup, brain magnetic resonant imaging was done and partially empty sella was diagnosed.</p><p><strong>Conclusion: </strong>Diabetes insipidus secondary to partially empty sella is uncommon. In patients presenting with headache and anterior or posterior pituitary dysfunction, empty sella should be considered, whether partial or complete.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"211"},"PeriodicalIF":2.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of Oleoylethanolamide supplementation on lipid profile, fasting blood sugar and dietary habits in obese people: a randomized double-blind placebo-control trial. 补充油酰乙醇酰胺对肥胖者血脂、空腹血糖和饮食习惯的影响:随机双盲安慰剂对照试验。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-08 DOI: 10.1186/s12902-024-01738-7
Alireza Ostadrahimi, Yaser Khajebishak, Fardin Moradi, Laleh Payahoo

Background: Abnormalities in biochemical parameters and changes in eating habits are considered complications of obesity. Oleoylethanolamide (OEA), an endocannabinoid-like compound, has been shown to have protective effects on many metabolic disorders. Given this evidence, the present study aimed to assess the effects of OEA on lipid profile parameters, fasting blood sugar (FBS), and dietary habits in healthy obese people.

Methods: In this randomized, double-blind, placebo-controlled clinical trial, which was carried out in 2016 in Tabriz, Iran, 60 obese people were enrolled in the study based on inclusion criteria. The intervention group consumed 125 mg of OEA capsules, and the placebo group received the same amount of starch twice for 8 weeks. Blood samples (5 mL) were taken at baseline and the end of the study in a fasting state. Serum concentrations of FBS, triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and total cholesterol (TC) were measured by enzymatic methods using commercial kits. The low-density lipoprotein cholesterol (LDL-C) concentration was obtained using the Friede-Wald formula. To assess dietary habits, a food frequency questionnaire (147 items) was used at baseline and the end of the study. A value less than < 0.05 was considered to indicate statistical significance.

Results: The TG concentration decreased significantly in the intervention group (mean (SD): 166.29 (70.01) mg/dL to 142.22 (48.05) mg/dL, p = 0.047). Changes in the placebo group were not significant (p > 0.05). After adjusting for baseline values and demographic characteristics, the difference in TG between groups remained significant (p = 0.044). Changes in other biochemical parameters were not significant. There was no significant difference between or within groups in terms of food groups.

Conclusion: OEA, as a complementary agent, plays a protective role in TG regulation. However, future studies with longer durations are needed to explore the impact of OEA on regulating dietary habits and to identify the mechanisms related to metabolic abnormalities in obese people.

Trial registration: The study was registered in the Iranian Registry of Clinical Trials (IRCT) center as IRCT201607132017N30 with URL. www.IRCT.IR in date 03/10/2016.

背景:生化指标异常和饮食习惯改变被认为是肥胖症的并发症。油酰乙醇酰胺(OEA)是一种类似于内源性大麻素的化合物,已被证明对许多代谢紊乱具有保护作用。鉴于这些证据,本研究旨在评估 OEA 对健康肥胖者的血脂谱参数、空腹血糖(FBS)和饮食习惯的影响:这项随机、双盲、安慰剂对照临床试验于 2016 年在伊朗大不里士进行,根据纳入标准,60 名肥胖者被纳入研究。干预组服用 125 毫克 OEA 胶囊,安慰剂组两次服用相同量的淀粉,为期 8 周。分别在基线和研究结束时空腹抽取血液样本(5 毫升)。血清中的 FBS、甘油三酯(TGs)、高密度脂蛋白胆固醇(HDL-C)和总胆固醇(TC)的浓度是通过酶法使用商业试剂盒测定的。低密度脂蛋白胆固醇(LDL-C)浓度采用弗里德-瓦尔德公式计算得出。为了评估饮食习惯,在基线和研究结束时使用了食物频率问卷(147 项)。结果干预组的 TG 浓度明显降低(平均值(标清):166.29 (70.01) mg/dL 降至 142.22 (48.05) mg/dL,p = 0.047)。安慰剂组的变化不显著(p > 0.05)。调整基线值和人口统计学特征后,各组之间的总胆固醇差异仍然显著(p = 0.044)。其他生化指标的变化不显著。在食物组别方面,组间和组内均无明显差异:结论:作为一种补充剂,OEA 对总胆固醇的调节具有保护作用。结论:OEA 作为一种补充剂,在调节总胆固醇方面发挥着保护作用。不过,今后还需要进行持续时间更长的研究,以探讨 OEA 对调节饮食习惯的影响,并确定与肥胖者代谢异常有关的机制:该研究已在伊朗临床试验注册中心(IRCT)注册,注册号为 IRCT201607132017N30,网址为 www.IRCT.IR,注册日期为 2016 年 10 月 3 日。
{"title":"The effect of Oleoylethanolamide supplementation on lipid profile, fasting blood sugar and dietary habits in obese people: a randomized double-blind placebo-control trial.","authors":"Alireza Ostadrahimi, Yaser Khajebishak, Fardin Moradi, Laleh Payahoo","doi":"10.1186/s12902-024-01738-7","DOIUrl":"10.1186/s12902-024-01738-7","url":null,"abstract":"<p><strong>Background: </strong>Abnormalities in biochemical parameters and changes in eating habits are considered complications of obesity. Oleoylethanolamide (OEA), an endocannabinoid-like compound, has been shown to have protective effects on many metabolic disorders. Given this evidence, the present study aimed to assess the effects of OEA on lipid profile parameters, fasting blood sugar (FBS), and dietary habits in healthy obese people.</p><p><strong>Methods: </strong>In this randomized, double-blind, placebo-controlled clinical trial, which was carried out in 2016 in Tabriz, Iran, 60 obese people were enrolled in the study based on inclusion criteria. The intervention group consumed 125 mg of OEA capsules, and the placebo group received the same amount of starch twice for 8 weeks. Blood samples (5 mL) were taken at baseline and the end of the study in a fasting state. Serum concentrations of FBS, triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and total cholesterol (TC) were measured by enzymatic methods using commercial kits. The low-density lipoprotein cholesterol (LDL-C) concentration was obtained using the Friede-Wald formula. To assess dietary habits, a food frequency questionnaire (147 items) was used at baseline and the end of the study. A value less than < 0.05 was considered to indicate statistical significance.</p><p><strong>Results: </strong>The TG concentration decreased significantly in the intervention group (mean (SD): 166.29 (70.01) mg/dL to 142.22 (48.05) mg/dL, p = 0.047). Changes in the placebo group were not significant (p > 0.05). After adjusting for baseline values and demographic characteristics, the difference in TG between groups remained significant (p = 0.044). Changes in other biochemical parameters were not significant. There was no significant difference between or within groups in terms of food groups.</p><p><strong>Conclusion: </strong>OEA, as a complementary agent, plays a protective role in TG regulation. However, future studies with longer durations are needed to explore the impact of OEA on regulating dietary habits and to identify the mechanisms related to metabolic abnormalities in obese people.</p><p><strong>Trial registration: </strong>The study was registered in the Iranian Registry of Clinical Trials (IRCT) center as IRCT201607132017N30 with URL. www.IRCT.IR in date 03/10/2016.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"210"},"PeriodicalIF":2.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge of diabetes mellitus complication prevention among patients in the central region of Ghana. 加纳中部地区患者对糖尿病并发症预防知识的了解。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-10-03 DOI: 10.1186/s12902-024-01744-9
Christiana Asiedu, Evans Owusu-Berning, Isaac Aidoo Erzuah

Diabetes Mellitus (DM) is a serious worldwide health issue that has put pressure on the global economy. The study examined the knowledge of complication prevention among patients living with Diabetes Mellitus (DM) in Ghana. The research was a quantitative study which involved the use of descriptive cross-sectional survey design. In all, 301 DM patients were included in the study. Data were processed using the Statistical Package for the Social Sciences (SPSS) version 25. The study recorded 66.12% (n = 199) good knowledge level. Therefore, educational intervention programme should be organized by the health professionals at Twifo-Atti Morkwa hospital so every DM patient would have optimum knowledge about the disease that would ensure prevention of the DM complications.

糖尿病(DM)是一个严重的世界性健康问题,对全球经济造成了压力。本研究调查了加纳糖尿病(DM)患者对并发症预防知识的了解情况。研究采用描述性横断面调查设计,是一项定量研究。共有 301 名糖尿病患者参与了研究。数据使用社会科学统计软件包(SPSS)第 25 版进行处理。研究结果显示,66.12%(n = 199)的患者对糖尿病有良好的认知水平。因此,Twifo-Atti Morkwa 医院的医护人员应组织教育干预计划,使每位糖尿病患者都能获得最佳的疾病知识,从而确保预防糖尿病并发症。
{"title":"Knowledge of diabetes mellitus complication prevention among patients in the central region of Ghana.","authors":"Christiana Asiedu, Evans Owusu-Berning, Isaac Aidoo Erzuah","doi":"10.1186/s12902-024-01744-9","DOIUrl":"10.1186/s12902-024-01744-9","url":null,"abstract":"<p><p>Diabetes Mellitus (DM) is a serious worldwide health issue that has put pressure on the global economy. The study examined the knowledge of complication prevention among patients living with Diabetes Mellitus (DM) in Ghana. The research was a quantitative study which involved the use of descriptive cross-sectional survey design. In all, 301 DM patients were included in the study. Data were processed using the Statistical Package for the Social Sciences (SPSS) version 25. The study recorded 66.12% (n = 199) good knowledge level. Therefore, educational intervention programme should be organized by the health professionals at Twifo-Atti Morkwa hospital so every DM patient would have optimum knowledge about the disease that would ensure prevention of the DM complications.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"209"},"PeriodicalIF":2.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11451242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessments of coagulation profile among good glycemic control and poor glycemic control type 2 diabetic patient attending at Wolkite University specialized hospital, Central Ethiopia: a comparative study. 在埃塞俄比亚中部沃尔基特大学专科医院就诊的血糖控制良好和血糖控制不佳的 2 型糖尿病患者的凝血状况评估:一项比较研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01730-1
Bisrat Fikadu Habtu, Seid Abrar, Dereje Abebe, Zuber Hajikelil

Introduction: Diabetes Mellitus (DM) is a worldwide health issue that is defined by elevated blood glucose levels and impaired metabolism of fat, carbohydrates, and proteins. Atherosthrombotic events are very likely to occur in patients with diabetes mellitus. This results in the development of both microvascular and macrovascular complications.

Objective: To compare the coagulation profile parameters between patients with good glycemic control and poor glycemic control and to evaluate the association of coagulation profile and glycemic control in type 2 DM patients.

Materials and methods: This study was conducted in Wolkite university specialized hospital on 90 type 2 Diabetics patients among which 45 were with good glycemic control and 45 were with poor glycemic control. Seven ml blood samples were collected from each study participant and analyzed to assess coagulation profile including Platelet Count, activated Partial Thromboplastin Time (aPTT), and Prothrombin Time (PT). Using SPSS 21.0, an independent sample t-test was used for statistical analysis.

Results: According to the current study, when comparing Type 2 Diabetes with poor glycemic control to those with good glycemic control, there was an increase in PT and aPTT concentration (statistically significant, p < 0.05). The platelet counts of the two groups did not differ significantly.

Conclusion: People with Type 2 diabetes have altered coagulation profiles, which have demonstrated that hyperglycemia causes abnormalities in coagulation. Patients with Type 2 diabetes who have poor glycemic control are particularly vulnerable to atherothrombotic and hemorrhagic events. In order to prevent the onset of microvascular and macrovascular illness as soon as possible, physicians may find it helpful to evaluate the coagulation profile of diabetic patients.

简介糖尿病(DM)是一个世界性的健康问题,表现为血糖水平升高以及脂肪、碳水化合物和蛋白质的新陈代谢受损。糖尿病患者很容易发生动脉粥样硬化血栓事件。目的:比较糖尿病患者的凝血功能指标:比较血糖控制良好和血糖控制不佳患者的凝血谱参数,并评估 2 型糖尿病患者凝血谱与血糖控制的关联:本研究在沃尔凯特大学专科医院对 90 名 2 型糖尿病患者进行了研究,其中 45 名患者血糖控制良好,45 名患者血糖控制不佳。研究人员采集了每位患者的 7 毫升血液样本,并对其进行分析,以评估凝血情况,包括血小板计数、活化部分凝血活酶时间(aPTT)和凝血酶原时间(PT)。统计分析采用 SPSS 21.0 进行独立样本 t 检验:本次研究显示,血糖控制不佳的 2 型糖尿病患者与血糖控制良好的 2 型糖尿病患者相比,PT 和 aPTT 浓度增加(具有统计学意义,P 结论:血糖控制不佳的 2 型糖尿病患者与血糖控制良好的 2 型糖尿病患者相比,PT 和 aPTT 浓度增加(具有统计学意义,P 结论):2 型糖尿病患者的凝血功能会发生改变,这表明高血糖会导致凝血功能异常。血糖控制不佳的 2 型糖尿病患者特别容易发生动脉粥样血栓和出血事件。为了尽快预防微血管和大血管疾病的发生,医生可能会发现对糖尿病患者的凝血功能进行评估很有帮助。
{"title":"Assessments of coagulation profile among good glycemic control and poor glycemic control type 2 diabetic patient attending at Wolkite University specialized hospital, Central Ethiopia: a comparative study.","authors":"Bisrat Fikadu Habtu, Seid Abrar, Dereje Abebe, Zuber Hajikelil","doi":"10.1186/s12902-024-01730-1","DOIUrl":"10.1186/s12902-024-01730-1","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes Mellitus (DM) is a worldwide health issue that is defined by elevated blood glucose levels and impaired metabolism of fat, carbohydrates, and proteins. Atherosthrombotic events are very likely to occur in patients with diabetes mellitus. This results in the development of both microvascular and macrovascular complications.</p><p><strong>Objective: </strong>To compare the coagulation profile parameters between patients with good glycemic control and poor glycemic control and to evaluate the association of coagulation profile and glycemic control in type 2 DM patients.</p><p><strong>Materials and methods: </strong>This study was conducted in Wolkite university specialized hospital on 90 type 2 Diabetics patients among which 45 were with good glycemic control and 45 were with poor glycemic control. Seven ml blood samples were collected from each study participant and analyzed to assess coagulation profile including Platelet Count, activated Partial Thromboplastin Time (aPTT), and Prothrombin Time (PT). Using SPSS 21.0, an independent sample t-test was used for statistical analysis.</p><p><strong>Results: </strong>According to the current study, when comparing Type 2 Diabetes with poor glycemic control to those with good glycemic control, there was an increase in PT and aPTT concentration (statistically significant, p < 0.05). The platelet counts of the two groups did not differ significantly.</p><p><strong>Conclusion: </strong>People with Type 2 diabetes have altered coagulation profiles, which have demonstrated that hyperglycemia causes abnormalities in coagulation. Patients with Type 2 diabetes who have poor glycemic control are particularly vulnerable to atherothrombotic and hemorrhagic events. In order to prevent the onset of microvascular and macrovascular illness as soon as possible, physicians may find it helpful to evaluate the coagulation profile of diabetic patients.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"204"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies. 二甲双胍治疗 2 型糖尿病患者的胃肠道不良反应:对观察性研究的系统回顾和元回归分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01727-w
Katarzyna Nabrdalik, Mirela Hendel, Krzysztof Irlik, Hanna Kwiendacz, Igor Łoniewski, Tommaso Bucci, Uazman Alam, Gregory Y H Lip, Janusz Gumprecht, Karolina Skonieczna-Żydecka

Introduction: Metformin is the most prescribed medication for type 2 diabetes mellitus (T2DM); there is a well-established link with the elevated incidence of gastrointestinal (GI) adverse events (AE) limiting its administration or intensification.

Objectives: The objective of this systematic review and meta-analysis of observational studies was to evaluate the pooled incidence of GI AE related to metformin use in patients with T2DM.

Materials and methods: PUB MED/CINAHL/Web of Science/Scopus were searched from database inception until 29.07.2024 for observational studies in English describing the frequency of GI AE in patients with T2DM treated with metformin. Random-effects meta-analyses were used to derive effect sizes: event rates.

Results: From 7019 publications, we identified 211 potentially eligible full-text articles. Ultimately, 21 observational studies were included in the meta-analysis. The prevalence of GI AE was as follows: diarrhea 6.9% (95% CI: 0.038-0.123), bloating 6,2% (95% CI: 0.020-0.177), abdominal pain 5,3% (95% CI: 0.003-0.529), vomiting 2.4% (95%: CI 0.007-0.075), constipation 1.1% (95%: CI 0.001-0.100). The incidence of bloating (coefficient -4.46; p < 0.001), diarrhea (coefficient -1.17; p = 0.0951) abdominal pain (coefficient -2.80; p = 0.001), constipation (coefficient -5.78; p = 0.0014) and vomiting (coefficient -2.47; p < 0.001) were lower for extended release (XR) metformin than metformin immediate release (IR) formulation.

Conclusions: This study highlights the prevalence of GI AE in patients receiving metformin, with a diarrhea predominance, followed by bloating, diarrhea, abdominal pain, constipation, and vomiting. The incidence is lower in patients administered with XR metformin.

Trial registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021289975 , identifier CRD42021289975.

简介二甲双胍是治疗 2 型糖尿病(T2DM)最常用的处方药;胃肠道不良事件(AE)发生率的升高限制了二甲双胍的使用或加强,这一点已得到公认:本观察性研究的系统综述和荟萃分析旨在评估与 T2DM 患者使用二甲双胍相关的胃肠道不良事件的总体发生率:从数据库建立之初到 2024 年 7 月 29 日,在 PUB MED/CINAHL/Web of Science/Scopus 上检索了描述二甲双胍治疗 T2DM 患者消化道 AE 发生率的英文观察性研究。采用随机效应荟萃分析得出效应大小:事件发生率:从 7019 篇出版物中,我们发现了 211 篇可能符合条件的全文文章。最终,21 项观察性研究被纳入荟萃分析。消化道 AE 的发生率如下:腹泻 6.9% (95% CI: 0.038-0.123)、腹胀 6.2% (95% CI: 0.020-0.177)、腹痛 5.3% (95% CI: 0.003-0.529)、呕吐 2.4% (95% CI: 0.007-0.075)、便秘 1.1% (95% CI: 0.001-0.100)。腹胀的发生率(系数-4.46;P 结论:该研究强调了胃肠道并发症的发生率:本研究强调了接受二甲双胍治疗的患者消化道 AE 的发生率,其中以腹泻为主,其次是腹胀、腹泻、腹痛、便秘和呕吐。使用XR二甲双胍的患者发病率较低。试验注册:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021289975 ,标识符为CRD42021289975。
{"title":"Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies.","authors":"Katarzyna Nabrdalik, Mirela Hendel, Krzysztof Irlik, Hanna Kwiendacz, Igor Łoniewski, Tommaso Bucci, Uazman Alam, Gregory Y H Lip, Janusz Gumprecht, Karolina Skonieczna-Żydecka","doi":"10.1186/s12902-024-01727-w","DOIUrl":"10.1186/s12902-024-01727-w","url":null,"abstract":"<p><strong>Introduction: </strong>Metformin is the most prescribed medication for type 2 diabetes mellitus (T2DM); there is a well-established link with the elevated incidence of gastrointestinal (GI) adverse events (AE) limiting its administration or intensification.</p><p><strong>Objectives: </strong>The objective of this systematic review and meta-analysis of observational studies was to evaluate the pooled incidence of GI AE related to metformin use in patients with T2DM.</p><p><strong>Materials and methods: </strong>PUB MED/CINAHL/Web of Science/Scopus were searched from database inception until 29.07.2024 for observational studies in English describing the frequency of GI AE in patients with T2DM treated with metformin. Random-effects meta-analyses were used to derive effect sizes: event rates.</p><p><strong>Results: </strong>From 7019 publications, we identified 211 potentially eligible full-text articles. Ultimately, 21 observational studies were included in the meta-analysis. The prevalence of GI AE was as follows: diarrhea 6.9% (95% CI: 0.038-0.123), bloating 6,2% (95% CI: 0.020-0.177), abdominal pain 5,3% (95% CI: 0.003-0.529), vomiting 2.4% (95%: CI 0.007-0.075), constipation 1.1% (95%: CI 0.001-0.100). The incidence of bloating (coefficient -4.46; p < 0.001), diarrhea (coefficient -1.17; p = 0.0951) abdominal pain (coefficient -2.80; p = 0.001), constipation (coefficient -5.78; p = 0.0014) and vomiting (coefficient -2.47; p < 0.001) were lower for extended release (XR) metformin than metformin immediate release (IR) formulation.</p><p><strong>Conclusions: </strong>This study highlights the prevalence of GI AE in patients receiving metformin, with a diarrhea predominance, followed by bloating, diarrhea, abdominal pain, constipation, and vomiting. The incidence is lower in patients administered with XR metformin.</p><p><strong>Trial registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021289975 , identifier CRD42021289975.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"206"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative pancytopenia in a patient with giant parathyroid adenoma and brown tumor: a case report. 一名患有巨大甲状旁腺腺瘤和棕色瘤的患者术后出现全血细胞减少:病例报告。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01742-x
Wen-Ting Pan, Zhi-Hong Zhao, Kun Wang, Zhi-Yuan He, Liang Ou

Background: Parathyroid adenoma is the primary cause of primary hyperparathyroidism, commonly presenting with elevated parathyroid hormone (PTH) and blood calcium levels. Chronic primary hyperparathyroidism often results in bone destruction, resulting in the formation of brown tumors. The preferred clinical treatment for parathyroid adenoma is parathyroidectomy. Postoperative pancytopenia, although rare, is a critical complication that warrants further investigation into its mechanisms and management strategies.

Case presentation: We present a case of a 59-year-old female patient who was admitted due to nausea and vomiting. Positron emission tomography-computed tomography (PET-CT) revealed a mass posterior to the left thyroid lobe and multiple areas of fibrocystic osteitis throughout the body. Hematological tests showed elevated serum calcium and parathyroid hormone (PTH) levels. The patient subsequently underwent parathyroidectomy, and pathological examination confirmed the presence of a parathyroid adenoma. Postoperatively, the patient developed pancytopenia and received symptomatic treatment such as correction of anemia and elevation of white blood. At the two-month follow-up, all indicators had returned to normal.

Conclusions: Pancytopenia is commonly seen in bone marrow diseases, infections and immune-related disorders, nutritional deficiencies, and metabolic diseases. This case confirms that pancytopenia can also occur postoperatively in patients with parathyroid adenoma. Therefore, Clinicians should be aware of the potential for postoperative pancytopenia following parathyroidectomy and the need for prompt management.

背景:甲状旁腺腺瘤是原发性甲状旁腺功能亢进症的主要病因,通常表现为甲状旁腺激素(PTH)和血钙水平升高。慢性原发性甲状旁腺功能亢进通常会导致骨质破坏,形成褐色肿瘤。甲状旁腺腺瘤的首选临床治疗方法是甲状旁腺切除术。术后全血细胞减少虽然罕见,但却是一种严重的并发症,需要进一步研究其机制和治疗策略:我们介绍了一例 59 岁的女性患者,她因恶心和呕吐入院。正电子发射计算机断层扫描(PET-CT)显示左甲状腺叶后方有肿块,全身多处有纤维囊性骨炎。血液学检查显示血清钙和甲状旁腺激素(PTH)水平升高。患者随后接受了甲状旁腺切除术,病理检查证实了甲状旁腺腺瘤的存在。术后,患者出现全血细胞减少,接受了纠正贫血和升高白细胞等对症治疗。在两个月的随访中,所有指标均恢复正常:全血细胞减少症常见于骨髓疾病、感染和免疫相关疾病、营养缺乏和代谢性疾病。本病例证实,甲状旁腺腺瘤患者术后也可能出现全血细胞减少。因此,临床医生应意识到甲状旁腺切除术后可能会出现全血细胞减少的情况,并需要及时处理。
{"title":"Postoperative pancytopenia in a patient with giant parathyroid adenoma and brown tumor: a case report.","authors":"Wen-Ting Pan, Zhi-Hong Zhao, Kun Wang, Zhi-Yuan He, Liang Ou","doi":"10.1186/s12902-024-01742-x","DOIUrl":"10.1186/s12902-024-01742-x","url":null,"abstract":"<p><strong>Background: </strong>Parathyroid adenoma is the primary cause of primary hyperparathyroidism, commonly presenting with elevated parathyroid hormone (PTH) and blood calcium levels. Chronic primary hyperparathyroidism often results in bone destruction, resulting in the formation of brown tumors. The preferred clinical treatment for parathyroid adenoma is parathyroidectomy. Postoperative pancytopenia, although rare, is a critical complication that warrants further investigation into its mechanisms and management strategies.</p><p><strong>Case presentation: </strong>We present a case of a 59-year-old female patient who was admitted due to nausea and vomiting. Positron emission tomography-computed tomography (PET-CT) revealed a mass posterior to the left thyroid lobe and multiple areas of fibrocystic osteitis throughout the body. Hematological tests showed elevated serum calcium and parathyroid hormone (PTH) levels. The patient subsequently underwent parathyroidectomy, and pathological examination confirmed the presence of a parathyroid adenoma. Postoperatively, the patient developed pancytopenia and received symptomatic treatment such as correction of anemia and elevation of white blood. At the two-month follow-up, all indicators had returned to normal.</p><p><strong>Conclusions: </strong>Pancytopenia is commonly seen in bone marrow diseases, infections and immune-related disorders, nutritional deficiencies, and metabolic diseases. This case confirms that pancytopenia can also occur postoperatively in patients with parathyroid adenoma. Therefore, Clinicians should be aware of the potential for postoperative pancytopenia following parathyroidectomy and the need for prompt management.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"208"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin resistance and insulin secretory defect among Bangalee PCOS women: a case-control study. 班加罗尔多囊卵巢综合征妇女的胰岛素抵抗和胰岛素分泌缺陷:一项病例对照研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01720-3
Jannatul Nayeem, M M Towhidul Islam, Farzana Deeba, Shahjada Selim, Liaquat Ali, Yearul Kabir

Insulin resistance (IR) is a well-recognized covariate of Polycystic Ovarian Syndrome (PCOS) with varying burden and risk factors among populations. The relationship of insulin secretory defect or ISD with PCOS is less understood. The presence of IR and ISD as well as their covariates have been explored in the present case-control study among young adult to early middle-aged, normal weight to obese, Bangalee women with PCOS. A number of 158 PCOS [age 23 (15-34) years, Median (Range)] and 126 Non-PCOS [24 (19-34) years] females were recruited purposively with PCOS diagnosed following Modified Rotterdam Criteria 2003. Hormones were measured by CLIA method and lower abdominal ultrasonography was done by trained personnel. IR and ISD were assessed by homeostasis model assessment with 75th percentile values of HOMA-IR (2.4) and HOMA%B (143) in Non-PCOS group considered as the cut-off values. Hyperandrogenism (HA) was measured by calculating Fasting Androgen Index (FAI). HOMA-IR was high among 52% of PCOS and 28% of Non-PCOS women. Body Mass Index (BMI) and HA were independently associated covariates of IR (p < 0.001). HOMA%B was compromised among 48% of PCOS subjects and the deficiency showed independent association (p < 0.001) with 2 h glycemia on OGTT in Non-PCOS and HA in PCOS groups. The data suggest insulin resistance as a major risk factor for PCOS among Bangalee women with obesity and hyperandrogenemia as its major covariates. The findings also indicate that presence of impaired insulin secretion is a major determinant of hyperglycemia and, consequently, of higher T2DM risk among young women in this population.

胰岛素抵抗(IR)是多囊卵巢综合征(PCOS)的一个公认的协变量,其负担和风险因素在不同人群中各不相同。胰岛素分泌缺陷(ISD)与多囊卵巢综合征的关系还不太清楚。本病例对照研究对患有多囊卵巢综合症的年轻成人至中年早期、体重正常至肥胖的班加罗尔妇女进行了研究,探讨了 IR 和 ISD 的存在及其协变量。研究有目的性地招募了 158 名多囊卵巢综合症女性(年龄 23(15-34)岁,中位数(范围))和 126 名非多囊卵巢综合症女性(24(19-34)岁),她们都是根据 2003 年修订的鹿特丹标准诊断出的多囊卵巢综合症患者。激素采用 CLIA 方法进行测量,下腹部超声波检查由受过培训的人员进行。以非多囊卵巢综合征组的 HOMA-IR 第 75 百分位值(2.4)和 HOMA%B 第 75 百分位值(143)为临界值,通过稳态模型评估 IR 和 ISD。高雄激素症(HA)通过计算空腹雄激素指数(FAI)来衡量。52% 的多囊卵巢综合症妇女和 28% 的非多囊卵巢综合症妇女的 HOMA-IR 偏高。体重指数(BMI)和 HA 是 IR 的独立相关协变量(p
{"title":"Insulin resistance and insulin secretory defect among Bangalee PCOS women: a case-control study.","authors":"Jannatul Nayeem, M M Towhidul Islam, Farzana Deeba, Shahjada Selim, Liaquat Ali, Yearul Kabir","doi":"10.1186/s12902-024-01720-3","DOIUrl":"10.1186/s12902-024-01720-3","url":null,"abstract":"<p><p>Insulin resistance (IR) is a well-recognized covariate of Polycystic Ovarian Syndrome (PCOS) with varying burden and risk factors among populations. The relationship of insulin secretory defect or ISD with PCOS is less understood. The presence of IR and ISD as well as their covariates have been explored in the present case-control study among young adult to early middle-aged, normal weight to obese, Bangalee women with PCOS. A number of 158 PCOS [age 23 (15-34) years, Median (Range)] and 126 Non-PCOS [24 (19-34) years] females were recruited purposively with PCOS diagnosed following Modified Rotterdam Criteria 2003. Hormones were measured by CLIA method and lower abdominal ultrasonography was done by trained personnel. IR and ISD were assessed by homeostasis model assessment with 75th percentile values of HOMA-IR (2.4) and HOMA%B (143) in Non-PCOS group considered as the cut-off values. Hyperandrogenism (HA) was measured by calculating Fasting Androgen Index (FAI). HOMA-IR was high among 52% of PCOS and 28% of Non-PCOS women. Body Mass Index (BMI) and HA were independently associated covariates of IR (p < 0.001). HOMA%B was compromised among 48% of PCOS subjects and the deficiency showed independent association (p < 0.001) with 2 h glycemia on OGTT in Non-PCOS and HA in PCOS groups. The data suggest insulin resistance as a major risk factor for PCOS among Bangalee women with obesity and hyperandrogenemia as its major covariates. The findings also indicate that presence of impaired insulin secretion is a major determinant of hyperglycemia and, consequently, of higher T2DM risk among young women in this population.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"207"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of metabolic syndrome and its components with sarcopenia, and the mediating role of insulin resistance: Findings from NHANES database. 代谢综合征及其组成部分与肌肉疏松症的关系,以及胰岛素抵抗的中介作用:来自 NHANES 数据库的研究结果。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01736-9
Minghui Li, Rong Ji, Xi Liu, Yongjian Wu

Background: To investigate the association between metabolic syndrome (MetS) and its components with sarcopenia, and to explore the extent to which insulin resistance (IR) mediates this association, using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: We analyzed cross-sectional data from 15,779 adults in the NHANES from 1999 to 2006 and 2011-2018. Multivariable logistic regression models were used to determine the odds ratios (ORs) between MetS, its components, the number of MetS components, and sarcopenia. Mediation analysis was performed to explore the role of the homeostatic model assessment of insulin resistance (HOMA-IR) in MetS and its components-induced sarcopenia.

Result: In the fully adjusted model, MetS increased the prevalence of sarcopenia by 1.96-fold (95% CI: 1.73-2.22). Among the individual components, central obesity, hypertension, and hyperglycemia were associated with an increased prevalence of sarcopenia. Sarcopenia prevalence also increased linearly with the number of MetS components, with the highest prevalence observed in the presence of all five components (OR: 3.80, 95% CI: 2.79-5.16). Sex-stratified analysis showed that the prevalence of MetS for sarcopenia was higher in males than females. The mediating effects of HOMA-IR on the association between MetS and its components (central obesity, hypertension, and hyperglycemia) with sarcopenia were significant, with mediation effects of 51.7%, 30.7%, 33.2%, and 79.1%, respectively. There was no significant direct association between hyperglycemia and sarcopenia beyond the HOMA-IR pathway.

Conclusion: MetS and its individual components, excluding hypertriglyceridemia and low high density lipoprotein cholesterol, were associated with a higher prevalence of sarcopenia, especially in males. This association was partially or fully mediated by IR.

背景:利用美国国家健康与营养调查(NHANES)的数据,研究代谢综合征(MetS)及其成分与肌肉疏松症之间的关联,并探讨胰岛素抵抗(IR)在多大程度上介导了这种关联:我们分析了1999-2006年和2011-2018年NHANES调查中15779名成年人的横断面数据。采用多变量逻辑回归模型确定 MetS、其成分、MetS 成分数量和肌少症之间的几率比(ORs)。研究人员还进行了中介分析,以探讨胰岛素抵抗的稳态模型评估(HOMA-IR)在MetS及其成分诱发的肌肉疏松症中的作用:结果:在完全调整模型中,MetS 使肌肉疏松症的患病率增加了 1.96 倍(95% CI:1.73-2.22)。在各个组成部分中,中心性肥胖、高血压和高血糖与肌肉疏松症患病率增加有关。肌肉疏松症的患病率也随着 MetS 成分的数量呈线性增长,当所有五个成分都存在时,患病率最高(OR:3.80,95% CI:2.79-5.16)。性别分层分析显示,肌肉疏松症的 MetS 患病率男性高于女性。HOMA-IR对MetS及其组成部分(中心性肥胖、高血压和高血糖)与肌肉疏松症之间的关联有显著的中介效应,中介效应分别为51.7%、30.7%、33.2%和79.1%。除 HOMA-IR 途径外,高血糖与肌肉疏松症之间没有明显的直接关联:结论:除高甘油三酯血症和低高密度脂蛋白胆固醇外,MetS 及其各个组成部分与较高的肌肉疏松症发病率有关,尤其是在男性中。这种关联部分或完全由 IR 介导。
{"title":"Associations of metabolic syndrome and its components with sarcopenia, and the mediating role of insulin resistance: Findings from NHANES database.","authors":"Minghui Li, Rong Ji, Xi Liu, Yongjian Wu","doi":"10.1186/s12902-024-01736-9","DOIUrl":"10.1186/s12902-024-01736-9","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association between metabolic syndrome (MetS) and its components with sarcopenia, and to explore the extent to which insulin resistance (IR) mediates this association, using data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>We analyzed cross-sectional data from 15,779 adults in the NHANES from 1999 to 2006 and 2011-2018. Multivariable logistic regression models were used to determine the odds ratios (ORs) between MetS, its components, the number of MetS components, and sarcopenia. Mediation analysis was performed to explore the role of the homeostatic model assessment of insulin resistance (HOMA-IR) in MetS and its components-induced sarcopenia.</p><p><strong>Result: </strong>In the fully adjusted model, MetS increased the prevalence of sarcopenia by 1.96-fold (95% CI: 1.73-2.22). Among the individual components, central obesity, hypertension, and hyperglycemia were associated with an increased prevalence of sarcopenia. Sarcopenia prevalence also increased linearly with the number of MetS components, with the highest prevalence observed in the presence of all five components (OR: 3.80, 95% CI: 2.79-5.16). Sex-stratified analysis showed that the prevalence of MetS for sarcopenia was higher in males than females. The mediating effects of HOMA-IR on the association between MetS and its components (central obesity, hypertension, and hyperglycemia) with sarcopenia were significant, with mediation effects of 51.7%, 30.7%, 33.2%, and 79.1%, respectively. There was no significant direct association between hyperglycemia and sarcopenia beyond the HOMA-IR pathway.</p><p><strong>Conclusion: </strong>MetS and its individual components, excluding hypertriglyceridemia and low high density lipoprotein cholesterol, were associated with a higher prevalence of sarcopenia, especially in males. This association was partially or fully mediated by IR.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"203"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk and determinants of sarcopenia in people with diabetes: a case-control study from Qatar Biobank cohort. 糖尿病患者患肌肉疏松症的风险和决定因素:一项来自卡塔尔生物库队列的病例对照研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-30 DOI: 10.1186/s12902-024-01722-1
Hibeh Shatila, Nour Ghazal, Ghalya Bukshaisha, Shaikha Al-Zeyara, Cosette Fakih El Khoury, Maya Bassil

Background: Diabetes is associated with impairments in muscle mass and quality increasing the risk of sarcopenia. Thus, this study aimed to investigate the odds of sarcopenia and its associated risk factors among Qatari adults (> 18 years), while exploring the modulating effects of health and lifestyle factors.

Methods: Using a case-control design, data from 767 participants (481 cases with diabetes and 286 controls without diabetes) was collected from Qatar Biobank (QBB). Sociodemographic, lifestyle factors including dietary intake, anthropometric and biochemical measures were analyzed. Handgrip strength, Dual X-ray absorptiometry (DXA), and Bio-impedance were used to assess muscle strength, muscle mass and muscle quality, respectively. The risk of sarcopenia was estimated using the European consensus on definition and diagnosis of sarcopenia.

Results: Cases with diabetes were older (55 vs. 36 years; P < 0.001), had higher BMI (31.6 vs. 28.3 kg/m2; P < 0.001), lower cardiorespiratory fitness (50.0% "Moderate" fitness for cases, 62.9% "High" fitness for controls), and consumed less total (59.0 vs. 64.0; P = 0.004) and animal protein (39.0 vs. 42.0; P = 0.001), compared to controls based on a computed score. Participants with diabetes also had lower appendicular lean mass/BMI, handgrip strength, and higher probability of sarcopenia/probable sarcopenia (P < 0.005). Adjusted multiple logistic regression revealed that elevated cardiorespiratory fitness (β = 0.299, 95%CI:0.12-0.74) and blood triglycerides (β = 1.475, 95% CI: 1.024-2.124), as well as being a female (β = 0.086, 95%CI: 0.026-0.288) and having higher BMI (β = 0.908, 95%CI: 0.852-0.967) and ALM/BMI (β = 0.000, 95% CI: 0.000-0.007) are independent predictors (p < 0.05) of sarcopenia risk.

Conclusions: This study highlights the intricate relationship between diabetes and sarcopenia, revealing modifiable risk factors. Individuals with diabetes were found to have a higher likelihood of sarcopenia, which was associated with lower fitness levels and higher blood triglycerides. Protective factors against sarcopenia included being female and having higher BMI and ALM/BMI ratios.

背景:糖尿病与肌肉质量和质量受损有关,会增加患肌肉疏松症的风险。因此,本研究旨在调查卡塔尔成年人(18 岁以上)患肌肉疏松症的几率及其相关风险因素,同时探讨健康和生活方式因素的调节作用:采用病例对照设计,从卡塔尔生物库(Qatar Biobank,QBB)中收集了 767 名参与者(481 名糖尿病患者和 286 名非糖尿病对照者)的数据。对社会人口学、生活方式因素(包括饮食摄入量)、人体测量和生化指标进行了分析。手握力、双 X 射线吸收测量(DXA)和生物阻抗分别用于评估肌肉力量、肌肉质量和肌肉质量。根据欧洲关于肌肉疏松症定义和诊断的共识,对肌肉疏松症的风险进行了估计:结果:患有糖尿病的病例年龄更大(55 岁对 36 岁;P 结论:糖尿病与肌肉疏松症之间存在着错综复杂的关系:这项研究强调了糖尿病与肌肉疏松症之间错综复杂的关系,揭示了可改变的风险因素。研究发现,糖尿病患者患肌肉疏松症的可能性较高,这与体能水平较低和血甘油三酯较高有关。防止肌肉疏松症的保护因素包括女性、较高的体重指数和ALM/BMI比率。
{"title":"Risk and determinants of sarcopenia in people with diabetes: a case-control study from Qatar Biobank cohort.","authors":"Hibeh Shatila, Nour Ghazal, Ghalya Bukshaisha, Shaikha Al-Zeyara, Cosette Fakih El Khoury, Maya Bassil","doi":"10.1186/s12902-024-01722-1","DOIUrl":"10.1186/s12902-024-01722-1","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is associated with impairments in muscle mass and quality increasing the risk of sarcopenia. Thus, this study aimed to investigate the odds of sarcopenia and its associated risk factors among Qatari adults (> 18 years), while exploring the modulating effects of health and lifestyle factors.</p><p><strong>Methods: </strong>Using a case-control design, data from 767 participants (481 cases with diabetes and 286 controls without diabetes) was collected from Qatar Biobank (QBB). Sociodemographic, lifestyle factors including dietary intake, anthropometric and biochemical measures were analyzed. Handgrip strength, Dual X-ray absorptiometry (DXA), and Bio-impedance were used to assess muscle strength, muscle mass and muscle quality, respectively. The risk of sarcopenia was estimated using the European consensus on definition and diagnosis of sarcopenia.</p><p><strong>Results: </strong>Cases with diabetes were older (55 vs. 36 years; P < 0.001), had higher BMI (31.6 vs. 28.3 kg/m2; P < 0.001), lower cardiorespiratory fitness (50.0% \"Moderate\" fitness for cases, 62.9% \"High\" fitness for controls), and consumed less total (59.0 vs. 64.0; P = 0.004) and animal protein (39.0 vs. 42.0; P = 0.001), compared to controls based on a computed score. Participants with diabetes also had lower appendicular lean mass/BMI, handgrip strength, and higher probability of sarcopenia/probable sarcopenia (P < 0.005). Adjusted multiple logistic regression revealed that elevated cardiorespiratory fitness (β = 0.299, 95%CI:0.12-0.74) and blood triglycerides (β = 1.475, 95% CI: 1.024-2.124), as well as being a female (β = 0.086, 95%CI: 0.026-0.288) and having higher BMI (β = 0.908, 95%CI: 0.852-0.967) and ALM/BMI (β = 0.000, 95% CI: 0.000-0.007) are independent predictors (p < 0.05) of sarcopenia risk.</p><p><strong>Conclusions: </strong>This study highlights the intricate relationship between diabetes and sarcopenia, revealing modifiable risk factors. Individuals with diabetes were found to have a higher likelihood of sarcopenia, which was associated with lower fitness levels and higher blood triglycerides. Protective factors against sarcopenia included being female and having higher BMI and ALM/BMI ratios.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"205"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
BMC Endocrine Disorders
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1