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BMC Endocrine Disorders最新文献

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Combining triglyceride‑glucose index and novel anthropometric measures to predict mortality risk in patients with T2DM: a prospective cohort study. 结合甘油三酯-葡萄糖指数和新型人体测量方法预测T2DM患者死亡风险：一项前瞻性队列研究
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-16 DOI: 10.1186/s12902-025-02132-7
Yining Wang, Fei Wu, Hongfei Mo, Qinghua Yan, Hongjie Chu, Mengyan Wang, Yang Zhou, Huiting Yu, Shuyue Sun, Minna Cheng, Fan Wang, Yan Shi
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引用次数: 0
Interpreting the drop: concordance and disparity between a new point-of-care assay and laboratory intraoperative parathyroid hormone testing in parathyroid surgery. 解释下降：在甲状旁腺手术中新的点护理测定和实验室术中甲状旁腺激素检测之间的一致性和差异性。
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-13 DOI: 10.1186/s12902-025-02112-x
Devanshu Kwatra, William Wakeford, Munira Ally, Julia Dowsett, Anant Patel, Ahmad Moinie, George Mochloulis, Panagiotis A Dimitriadis
{"title":"Interpreting the drop: concordance and disparity between a new point-of-care assay and laboratory intraoperative parathyroid hormone testing in parathyroid surgery.","authors":"Devanshu Kwatra, William Wakeford, Munira Ally, Julia Dowsett, Anant Patel, Ahmad Moinie, George Mochloulis, Panagiotis A Dimitriadis","doi":"10.1186/s12902-025-02112-x","DOIUrl":"https://doi.org/10.1186/s12902-025-02112-x","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the impact of phthalate exposure on endocrine function in women with polycystic ovary syndrome. 探讨邻苯二甲酸盐暴露对多囊卵巢综合征女性内分泌功能的影响。
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-12 DOI: 10.1186/s12902-026-02166-5
Jalpa Patel, Hiral Chaudhary, Sonal Panchal, Kiransinh Rajput, Rushikesh Joshi

Background: Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder influenced by genetic, hormonal, and environmental factors. In the environmental context, phthalate esters, specifically Mono-2-ethylhexyl phthalate (MEHP) and Di-2-ethylhexyl phthalate (DEHP), have emerged as potential endocrine disruptors, demanding a mysterious role in PCOS.

Objective: The study aimed to compare demographic, biochemical parameters, and levels of phthalate esters, specifically MEHP and DEHP, in women with and without PCOS. The association between these phthalate esters and different biochemical markers was also of interest for investigation.

Methods: The study included 160 participants, 90 in the PCOS group and 70 in the control group. Demographic and biochemical parameters were measured and compared for both groups. The levels of MEHP and DEHP in serum were determined using High-Performance Liquid Chromatography (HPLC).

Results: The PCOS group had a significantly higher average age and Body Mass Index (BMI) compared to the control group (p < 0.0001). Testosterone and luteinizing hormone (LH) levels were significantly elevated in the PCOS group (p < 0.05). In contrast, estradiol, follicle-stimulating hormone (FSH), prolactin, LH/FSH ratio, dehydroepiandrosterone sulfate, and thyroid-stimulating hormone (TSH) levels showed no significant difference. Notably, MEHP and DEHP levels were significantly higher in the PCOS group compared to the control group (47.33 ± 27.67 vs. 31.09 ± 18.74, p < 0.0001 and 31.03 ± 25.76 vs. 22.98 ± 19.65, p = 0.03 respectively). DEHP levels in the PCOS group demonstrated significant positive correlations with LH levels, LH/FSH ratio, and estradiol levels. In contrast, MEHP levels showed no significant correlations with the evaluated biochemical parameters. Neither MEHP nor DEHP displayed significant correlations with any examined parameters in the control group.

Conclusion: This study underscores the elevated levels of MEHP and DEHP in women with PCOS, highlighting the potential influence of these environmental toxins in PCOS pathogenesis.

Clinical trial number: Not applicable.

背景：多囊卵巢综合征（PCOS）是一种受遗传、激素和环境因素影响的复杂内分泌疾病。在环境背景下，邻苯二甲酸酯，特别是邻苯二甲酸单-2-乙基己基酯（MEHP）和邻苯二甲酸二-2-乙基己基酯（DEHP），已成为潜在的内分泌干扰物，在PCOS中扮演着神秘的角色。目的：该研究旨在比较人口统计学、生化参数和邻苯二甲酸酯水平，特别是MEHP和DEHP，在有和没有PCOS的女性中。这些邻苯二甲酸酯与不同生化标志物之间的关系也值得研究。方法：160例患者，PCOS组90例，对照组70例。测量并比较两组的人口学和生化参数。采用高效液相色谱法测定血清中MEHP和DEHP的含量。结果：PCOS组的平均年龄和体重指数（BMI）明显高于对照组(p)。结论：本研究强调了PCOS女性MEHP和DEHP水平升高，突出了这些环境毒素在PCOS发病机制中的潜在影响。临床试验号：不适用。
{"title":"Investigating the impact of phthalate exposure on endocrine function in women with polycystic ovary syndrome.","authors":"Jalpa Patel, Hiral Chaudhary, Sonal Panchal, Kiransinh Rajput, Rushikesh Joshi","doi":"10.1186/s12902-026-02166-5","DOIUrl":"https://doi.org/10.1186/s12902-026-02166-5","url":null,"abstract":"<p><strong>Background: </strong>Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder influenced by genetic, hormonal, and environmental factors. In the environmental context, phthalate esters, specifically Mono-2-ethylhexyl phthalate (MEHP) and Di-2-ethylhexyl phthalate (DEHP), have emerged as potential endocrine disruptors, demanding a mysterious role in PCOS.</p><p><strong>Objective: </strong>The study aimed to compare demographic, biochemical parameters, and levels of phthalate esters, specifically MEHP and DEHP, in women with and without PCOS. The association between these phthalate esters and different biochemical markers was also of interest for investigation.</p><p><strong>Methods: </strong>The study included 160 participants, 90 in the PCOS group and 70 in the control group. Demographic and biochemical parameters were measured and compared for both groups. The levels of MEHP and DEHP in serum were determined using High-Performance Liquid Chromatography (HPLC).</p><p><strong>Results: </strong>The PCOS group had a significantly higher average age and Body Mass Index (BMI) compared to the control group (p < 0.0001). Testosterone and luteinizing hormone (LH) levels were significantly elevated in the PCOS group (p < 0.05). In contrast, estradiol, follicle-stimulating hormone (FSH), prolactin, LH/FSH ratio, dehydroepiandrosterone sulfate, and thyroid-stimulating hormone (TSH) levels showed no significant difference. Notably, MEHP and DEHP levels were significantly higher in the PCOS group compared to the control group (47.33 ± 27.67 vs. 31.09 ± 18.74, p < 0.0001 and 31.03 ± 25.76 vs. 22.98 ± 19.65, p = 0.03 respectively). DEHP levels in the PCOS group demonstrated significant positive correlations with LH levels, LH/FSH ratio, and estradiol levels. In contrast, MEHP levels showed no significant correlations with the evaluated biochemical parameters. Neither MEHP nor DEHP displayed significant correlations with any examined parameters in the control group.</p><p><strong>Conclusion: </strong>This study underscores the elevated levels of MEHP and DEHP in women with PCOS, highlighting the potential influence of these environmental toxins in PCOS pathogenesis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating spexin and adiponectin as early biomarkers of insulin resistance in pediatric obesity. 循环spexin和脂联素作为儿童肥胖胰岛素抵抗的早期生物标志物。
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-10 DOI: 10.1186/s12902-025-02148-z
Biyao Lian, Yi Ding, Hongai Zhang, Yuesheng Liu, Yanfeng Xiao, Chunyan Yin
{"title":"Circulating spexin and adiponectin as early biomarkers of insulin resistance in pediatric obesity.","authors":"Biyao Lian, Yi Ding, Hongai Zhang, Yuesheng Liu, Yanfeng Xiao, Chunyan Yin","doi":"10.1186/s12902-025-02148-z","DOIUrl":"https://doi.org/10.1186/s12902-025-02148-z","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum β2-microglobulin, cystatin-C, and urinary KIM-1 as predictors of early renal impairment in women with diabetes in pregnancy: a prospective cohort study. 血清β2-微球蛋白、胱抑素c和尿KIM-1作为妊娠期糖尿病妇女早期肾功能损害的预测因子：一项前瞻性队列研究
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-09 DOI: 10.1186/s12902-025-02149-y
Xue Zhao, Bing Li, Zhenping Zhang, Hua Nie
{"title":"Serum β2-microglobulin, cystatin-C, and urinary KIM-1 as predictors of early renal impairment in women with diabetes in pregnancy: a prospective cohort study.","authors":"Xue Zhao, Bing Li, Zhenping Zhang, Hua Nie","doi":"10.1186/s12902-025-02149-y","DOIUrl":"https://doi.org/10.1186/s12902-025-02149-y","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mean arterial pressure is not associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis. 在日本，平均动脉压与2型糖尿病无关：一项二次回顾性分析
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-09 DOI: 10.1186/s12902-025-02154-1
Huabo Zheng, Tangmeng Guo, Yichen Xu, Xinglin Chen
{"title":"Mean arterial pressure is not associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis.","authors":"Huabo Zheng, Tangmeng Guo, Yichen Xu, Xinglin Chen","doi":"10.1186/s12902-025-02154-1","DOIUrl":"https://doi.org/10.1186/s12902-025-02154-1","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the relationship between lymphatic system damage and insulin resistance in T2DM based on vascular periadventitial tensor analysis and triglyceride-glucose index. 基于血管外膜周张量分析和甘油三酯-葡萄糖指数探讨T2DM患者淋巴系统损伤与胰岛素抵抗的关系
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-08 DOI: 10.1186/s12902-025-02151-4
Shan Xu, Xu-Yang Wang, Dong Yang, Die Zhang, Li-Na Du, Qing-Qing Chen, Yun Yang, Lin Lin, Jing Shen, Jian-Lin Wu
{"title":"Exploring the relationship between lymphatic system damage and insulin resistance in T2DM based on vascular periadventitial tensor analysis and triglyceride-glucose index.","authors":"Shan Xu, Xu-Yang Wang, Dong Yang, Die Zhang, Li-Na Du, Qing-Qing Chen, Yun Yang, Lin Lin, Jing Shen, Jian-Lin Wu","doi":"10.1186/s12902-025-02151-4","DOIUrl":"https://doi.org/10.1186/s12902-025-02151-4","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of carbohydrate-modified diets on insulin sensitivity in children and adolescents with overweight/obesity: a systematic review and meta-analysis of randomized controlled trials. 碳水化合物改良饮食对超重/肥胖儿童和青少年胰岛素敏感性的影响：随机对照试验的系统回顾和荟萃分析
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-07 DOI: 10.1186/s12902-026-02163-8
Yasaman Khorshidi, Nazanin Moslehi, Faraneh Zolfaghari, Mahdieh Golzarand, Golaleh Asghari
{"title":"Effects of carbohydrate-modified diets on insulin sensitivity in children and adolescents with overweight/obesity: a systematic review and meta-analysis of randomized controlled trials.","authors":"Yasaman Khorshidi, Nazanin Moslehi, Faraneh Zolfaghari, Mahdieh Golzarand, Golaleh Asghari","doi":"10.1186/s12902-026-02163-8","DOIUrl":"10.1186/s12902-026-02163-8","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":"35"},"PeriodicalIF":3.3,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of skeletal muscle mass and visceral fat area with hyperuricemia in male adolescents. 男性青少年骨骼肌质量和内脏脂肪面积与高尿酸血症的相关性。
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-07 DOI: 10.1186/s12902-026-02162-9
Wen Mao, Qian Li, Guangjun Zhu, Linyan Cheng, Donglian Wang, Bo Shen, Yufen Zheng
{"title":"Correlation of skeletal muscle mass and visceral fat area with hyperuricemia in male adolescents.","authors":"Wen Mao, Qian Li, Guangjun Zhu, Linyan Cheng, Donglian Wang, Bo Shen, Yufen Zheng","doi":"10.1186/s12902-026-02162-9","DOIUrl":"10.1186/s12902-026-02162-9","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":"15"},"PeriodicalIF":3.3,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of short-term metformin in regulating zinc and adipose tissue-derived biomarkers in children with obesity and insulin resistance. 短期二甲双胍在调节肥胖和胰岛素抵抗儿童锌和脂肪组织来源的生物标志物中的作用。
IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
BMC Endocrine Disorders
Pub Date : 2026-01-07 DOI: 10.1186/s12902-025-02159-w
Humeyra Acikan, Ayse Isik, Emre Sarikaya, Sabahattin Muhtaroglu, Nihal Hatipoglu
{"title":"The role of short-term metformin in regulating zinc and adipose tissue-derived biomarkers in children with obesity and insulin resistance.","authors":"Humeyra Acikan, Ayse Isik, Emre Sarikaya, Sabahattin Muhtaroglu, Nihal Hatipoglu","doi":"10.1186/s12902-025-02159-w","DOIUrl":"10.1186/s12902-025-02159-w","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":"36"},"PeriodicalIF":3.3,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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