Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.12
H. Svitlyk, U.R. Bahan, O.V. Smalіukh, V. M. Salo
The aim of the work is to determine the peculiarities of the clinical course of Wellens syndrome due to the presence of critical occlusion of the medial segment of the anterior interventricular coronary artery bifurcation.Material and Methods. Clinical manifestations of the disease, including dynamics of ECG changes; coronary angiography data; results of echocardiographic and laboratory tests.Results. This article presents the peculiarities of the clinical course of Wellens syndrome in patient L., 70, who met the currently recognized diagnostic criteria of the syndrome, but the critical occlusion of the anterior interventricular branch of the left coronary artery was localized in its medial segment. Along with this, there was hemodynamically irrelevant stenosis of the proximal coronary artery section (60%). Electrocardiographic changes were consistent with pattern B (deeply inverted T waves in V2-V6). Сonditional normalization of the T waves, indicating the absence of repeated coronary artery occlusion after spontaneous reperfusion. Stenting of the anterior interventricular coronary artery vein of the left coronary artery prevented the possible occurrence of “stuttering” pattern and the occurrence of myocardial infarction.Conclusions. Acute coronary syndrome with complete coronary artery occlusion is often accompanied by spontaneous reperfusion, which contributes to the relief of chest pain and the appearance of characteristic T waves on ECG and is the basis of the so-called Wellens syndrome. The most frequent localization of coronary artery occlusion is the proximal segment of the anterior interventricular branch of the left coronary artery, but we witnessed the occlusion in the medial segment of these coronary arteries. Immediate coronary angiography with stenting of the occluded artery will prevent the occurrence of myocardial infarction in the patient.
{"title":"Wellens Syndrome on the basis of critical occlusion of the medial segment of the anterior ventricultural branch of the left coronary artery (clinical type)","authors":"H. Svitlyk, U.R. Bahan, O.V. Smalіukh, V. M. Salo","doi":"10.24061/2413-0737.xxvi.2.102.2022.12","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.12","url":null,"abstract":"The aim of the work is to determine the peculiarities of the clinical course of Wellens syndrome due to the presence of critical occlusion of the medial segment of the anterior interventricular coronary artery bifurcation.Material and Methods. Clinical manifestations of the disease, including dynamics of ECG changes; coronary angiography data; results of echocardiographic and laboratory tests.Results. This article presents the peculiarities of the clinical course of Wellens syndrome in patient L., 70, who met the currently recognized diagnostic criteria of the syndrome, but the critical occlusion of the anterior interventricular branch of the left coronary artery was localized in its medial segment. Along with this, there was hemodynamically irrelevant stenosis of the proximal coronary artery section (60%). Electrocardiographic changes were consistent with pattern B (deeply inverted T waves in V2-V6). Сonditional normalization of the T waves, indicating the absence of repeated coronary artery occlusion after spontaneous reperfusion. Stenting of the anterior interventricular coronary artery vein of the left coronary artery prevented the possible occurrence of “stuttering” pattern and the occurrence of myocardial infarction.Conclusions. Acute coronary syndrome with complete coronary artery occlusion is often accompanied by spontaneous reperfusion, which contributes to the relief of chest pain and the appearance of characteristic T waves on ECG and is the basis of the so-called Wellens syndrome. The most frequent localization of coronary artery occlusion is the proximal segment of the anterior interventricular branch of the left coronary artery, but we witnessed the occlusion in the medial segment of these coronary arteries. Immediate coronary angiography with stenting of the occluded artery will prevent the occurrence of myocardial infarction in the patient.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89437285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.9
N.V. Давидова, N.P. Hrygorieva, D.D. Salekhi
Objective. To study the content of reduced glutathione (GSH), activities of glutathione peroxidase (GP) and glutathione-S-transferase enzymes (GST) in blood and liver of rats exposed to subacute alcohol intoxication, its combination with caffeine intake or constant light exposure, and the possibility of their correction with melatonin.Materials and methods. Experiments were performed on 42 male rats weighing 180-200 g kept under standard conditions of the vivarium and artificial equinox. Alcohol intoxication was induced by intragastric administration 40 % ethanol at a dose of 7 ml/kg of body weight for 7 days. Caffeine was administered by gavage at a dose of 30 mg/kg of body weight.Results. Ethanol poisoning and its combination with caffeine intake or exposure to constant light resulted in a decrease in GSH level and GP activity in RBCs and liver, besides the combination of ethanol+light resulted in more pronounced depletion of the parameters. The combination of ethanol with caffeine resulted in less reduction of GSH level in the blood (by 25%) but more depletion of GSH in the liver (by 45% vs. control) than in ethanol-treated rats. There was an elevation of GST activity in the liver of all groups of alcoholized animals. Administration of 5 mg/kg melatonin for 7 days limited depletion in GSH and prevented the changes in GP and GST activities in the blood and liver of all groups of animals.Conclusions. Melatonin administration prevented ethanol-induced toxicity in rats exposed to ethanol and its combination with caffeine or constant light for 7 days by limiting the depletion in GSH and preventing the changes in GP and GST activities in the blood and liver of all groups of animals.
{"title":"The glutathione system state in rats exposed to ethanol intoxication, its combination with caffeine and modified photoperiod","authors":"N.V. Давидова, N.P. Hrygorieva, D.D. Salekhi","doi":"10.24061/2413-0737.xxvi.2.102.2022.9","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.9","url":null,"abstract":"Objective. To study the content of reduced glutathione (GSH), activities of glutathione peroxidase (GP) and glutathione-S-transferase enzymes (GST) in blood and liver of rats exposed to subacute alcohol intoxication, its combination with caffeine intake or constant light exposure, and the possibility of their correction with melatonin.Materials and methods. Experiments were performed on 42 male rats weighing 180-200 g kept under standard conditions of the vivarium and artificial equinox. Alcohol intoxication was induced by intragastric administration 40 % ethanol at a dose of 7 ml/kg of body weight for 7 days. Caffeine was administered by gavage at a dose of 30 mg/kg of body weight.Results. Ethanol poisoning and its combination with caffeine intake or exposure to constant light resulted in a decrease in GSH level and GP activity in RBCs and liver, besides the combination of ethanol+light resulted in more pronounced depletion of the parameters. The combination of ethanol with caffeine resulted in less reduction of GSH level in the blood (by 25%) but more depletion of GSH in the liver (by 45% vs. control) than in ethanol-treated rats. There was an elevation of GST activity in the liver of all groups of alcoholized animals. Administration of 5 mg/kg melatonin for 7 days limited depletion in GSH and prevented the changes in GP and GST activities in the blood and liver of all groups of animals.Conclusions. Melatonin administration prevented ethanol-induced toxicity in rats exposed to ethanol and its combination with caffeine or constant light for 7 days by limiting the depletion in GSH and preventing the changes in GP and GST activities in the blood and liver of all groups of animals.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82336020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.5
I. M. Nikitina, K.V. Mуkуtуn, Yu.V. Diadiushka
Based on clinical and statistical analysis, a study of the leading etiopathogenetic factors in the development of hyperplastic processes of the endometrium in patients of reproductive age was carried out.The aim of the study: to study the risk factors for hyperplasia and endometrial polyps in women of early reproductive age.Materials and methods. Clinical and statistical analysis of 120 patients of active reproductive age with verified atypical hyperproliferative pathology of the endometrium (hyperplasia and endometrial polyps) was included in the main group. The main group was divided into subgroups: Subgroup I - 45 women with endometrial hyperplasia, Subgroup II - 45 patients with endometrial polyps and Subgroup III - 30 patients with combined endometrial pathology (hyperplasia and endometrial polyps).Results of reseаrсh. The leading risk factors for the development of hyperplastic endometrial processes in women of the examined groups have been identified: aggravated heredity, high frequency of medical abortions, miscarriages and a history of abnormal births. There is a high incidence of gynecological and extragenital diseases, surgical interventions on the uterus and appendages in the examined contingent of women, which contributes to the development of endometrial pathology. It is established that the most common clinical manifestations of endometrial hyperproliferative processes are pain and hemorrhagic syndromes.Conclusions. Risk factors for hyperproliferative pathology of the endometrium in women of reproductive age are the following: burdened heredity (60.8%), concomitant extragenital pathology (57.4%), menstrual disorders (86.7%), impaired reproductive function; burdened gynecological anamnesis: chronic inflammatory processes of the uterus and appendages (45.8%), artificial (74.2%) and spontaneous (22.5%) abortions; intrauterine surgical interventions (26.7%).
{"title":"Analysis of risk factors for the development of hyperproliferative endometrial processes in women of reproductive age","authors":"I. M. Nikitina, K.V. Mуkуtуn, Yu.V. Diadiushka","doi":"10.24061/2413-0737.xxvi.2.102.2022.5","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.5","url":null,"abstract":"Based on clinical and statistical analysis, a study of the leading etiopathogenetic factors in the development of hyperplastic processes of the endometrium in patients of reproductive age was carried out.The aim of the study: to study the risk factors for hyperplasia and endometrial polyps in women of early reproductive age.Materials and methods. Clinical and statistical analysis of 120 patients of active reproductive age with verified atypical hyperproliferative pathology of the endometrium (hyperplasia and endometrial polyps) was included in the main group. The main group was divided into subgroups: Subgroup I - 45 women with endometrial hyperplasia, Subgroup II - 45 patients with endometrial polyps and Subgroup III - 30 patients with combined endometrial pathology (hyperplasia and endometrial polyps).Results of reseаrсh. The leading risk factors for the development of hyperplastic endometrial processes in women of the examined groups have been identified: aggravated heredity, high frequency of medical abortions, miscarriages and a history of abnormal births. There is a high incidence of gynecological and extragenital diseases, surgical interventions on the uterus and appendages in the examined contingent of women, which contributes to the development of endometrial pathology. It is established that the most common clinical manifestations of endometrial hyperproliferative processes are pain and hemorrhagic syndromes.Conclusions. Risk factors for hyperproliferative pathology of the endometrium in women of reproductive age are the following: burdened heredity (60.8%), concomitant extragenital pathology (57.4%), menstrual disorders (86.7%), impaired reproductive function; burdened gynecological anamnesis: chronic inflammatory processes of the uterus and appendages (45.8%), artificial (74.2%) and spontaneous (22.5%) abortions; intrauterine surgical interventions (26.7%).","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86665520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.1
O. Holubchenko, P. Flis
The aim of our work is to improve the quality of comprehensive orthodontic treatment by searching for the most favorable conditions and terms necessary for the implementation of the adaptive capacity of the body at the stages of reconstructive manipulations in patients with occlusal disorders of the dentofacial system resulting from dental interventions.Material and methods. A prospective group clinical study was carried out. Groups were formed due to the total clinical sample of 105 patients, age range 18-45 years (mean age 29.9±6.1 years) with iatrogenic functional prosthetic disorders complicated with a primary deep bite. Three clinical groups were identified. The first included 37 patients with predominantly muscular symptoms, the second - 42 patients with dysfunction of the temporomandibular joints, and the third included 26 patients who, in addition to muscle and / or joint symptoms, had primary neurogenic disorders. In order to compare the effectiveness of treatment, each of the clinical groups was divided into 2 subgroups depending on the treatment algorithm used; namely, the first subgroup included patients who were treated according to the scheme developed by us, and the second subgroup included patients treated according to the generally accepted method.Results. There was a decrease in the amplitude of bioelectrical activity and a reduction in the time of the activity period, and, accordingly, the approximation of the activity coefficient to one in patients with vertical abnormalities, aggravated by crowding of the teeth, occurred already at the stage of splint therapy.Conclusions. Our studies allow us to predict both the duration of treatment and the amount of occlusal correction combined with the reconstruction of the position of the lower jaw and the improvement of the general somatic state of the patient's body.
{"title":"Effectiveness evaluation of the interdisciplinary approach in the treatment of patients with iatrogenic functional disorders of the maxillofacial area associated with primary deep bite according to the dynamics of changes in electromyographic studies","authors":"O. Holubchenko, P. Flis","doi":"10.24061/2413-0737.xxvi.2.102.2022.1","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.1","url":null,"abstract":"The aim of our work is to improve the quality of comprehensive orthodontic treatment by searching for the most favorable conditions and terms necessary for the implementation of the adaptive capacity of the body at the stages of reconstructive manipulations in patients with occlusal disorders of the dentofacial system resulting from dental interventions.Material and methods. A prospective group clinical study was carried out. Groups were formed due to the total clinical sample of 105 patients, age range 18-45 years (mean age 29.9±6.1 years) with iatrogenic functional prosthetic disorders complicated with a primary deep bite. Three clinical groups were identified. The first included 37 patients with predominantly muscular symptoms, the second - 42 patients with dysfunction of the temporomandibular joints, and the third included 26 patients who, in addition to muscle and / or joint symptoms, had primary neurogenic disorders. In order to compare the effectiveness of treatment, each of the clinical groups was divided into 2 subgroups depending on the treatment algorithm used; namely, the first subgroup included patients who were treated according to the scheme developed by us, and the second subgroup included patients treated according to the generally accepted method.Results. There was a decrease in the amplitude of bioelectrical activity and a reduction in the time of the activity period, and, accordingly, the approximation of the activity coefficient to one in patients with vertical abnormalities, aggravated by crowding of the teeth, occurred already at the stage of splint therapy.Conclusions. Our studies allow us to predict both the duration of treatment and the amount of occlusal correction combined with the reconstruction of the position of the lower jaw and the improvement of the general somatic state of the patient's body.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79281093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.4
V. Moskaliuk, B. V. Syrota, I. Balaniuk, N.V. Сhernetska, S. R. Melenko, T. Kolotylo
The Omicron strain was first registered by WHO in South Africa on November 24, 2021. As of early 2022, cases of Omicron had been registered in more than 60 countries and regions. The Omicron is currently the world's dominant strain of SAR-CoV-2 with a propensity to spread rapidly. Although diseases caused by Omicron are predominantly asymptomatic and mild, rapid growth or morbidity may seriously overwhelm the global health system. In addition to the above, its sources of mutations, the nature of infection transmission and its resistance to vaccines have not been fully studied yet. This insufficient knowledge leads to obstacles in the fight against a pathogen in different regions of the world. This article analyzes the results of the research on the characteristics of the pathogen, its variability, transmission characteristics and possible implementation mechanisms, epidemic status, prevention and other anti-epidemic measures to develop against the strain of SARCoV-2.
{"title":"Epidemiological characteristics SAR-CoV-2 Omicron","authors":"V. Moskaliuk, B. V. Syrota, I. Balaniuk, N.V. Сhernetska, S. R. Melenko, T. Kolotylo","doi":"10.24061/2413-0737.xxvi.2.102.2022.4","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.4","url":null,"abstract":"The Omicron strain was first registered by WHO in South Africa on November 24, 2021. As of early 2022, cases of Omicron had been registered in more than 60 countries and regions. The Omicron is currently the world's dominant strain of SAR-CoV-2 with a propensity to spread rapidly. Although diseases caused by Omicron are predominantly asymptomatic and mild, rapid growth or morbidity may seriously overwhelm the global health system. In addition to the above, its sources of mutations, the nature of infection transmission and its resistance to vaccines have not been fully studied yet. This insufficient knowledge leads to obstacles in the fight against a pathogen in different regions of the world. This article analyzes the results of the research on the characteristics of the pathogen, its variability, transmission characteristics and possible implementation mechanisms, epidemic status, prevention and other anti-epidemic measures to develop against the strain of SARCoV-2.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74564511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.6
O. Smaliukh
The pathogenesis of acute coronary syndrome is based on the processes of atherosclerosis of coronary arteries and atherothrombosis, accompanied by the destruction of non-stable atherosclerotic plaque coating and, in the future, by thrombosis. Myocardial ischemia initiates local and systemic inflammatory responses with the release of pro-inflammatory cytokines, which trigger a cascade of reactions, contributing to the more profound damage to cardiomyocytes. That is why it is extremely important to determine the activity of proinflammatory cytokines in patients with acute coronary syndrome.The aim of the work. To investigate the indices of pro-inflammatory cytokines in patients with acute coronary syndrome.Materials and Methods. 33 patients with acute coronary syndrome, namely with unstable angina pectoris, who underwent inpatient treatment in the cardiology department of the Lviv hospital for emergency medicine, were examined. The patients were 12 (36%) males and 21 (64%) females, with an average age of 68.5±2 years. The patients received treatment according to modern protocols for medical care for patients with acute coronary syndrome without ST-segment elevation and recommendations of the European Heart Association. The control group consisted of 20 practically healthy individuals of the same age and status. The patients were subjected to general clinical and instrumental examination methods, proinflammatory interleukins in serum enzyme-linked immunosorbent assay (on admission for hospital treatment).Results of the research. It was found that in patients with acute coronary syndrome, pro-inflammatory cytokines (interleukin-1β, interleukin-6, interleukin-17, tumor necrosis factor-alpha) exceed the values of almost healthy individuals by almost 2 times (p˂0.01).Conclusion. In patients with acute coronary syndrome, there is a significant (p˂0.01) increase in pro-inflammatory cytokines, which indicates the direct involvement of inflammation in the pathogenesis of the pathological process and requires appropriate correction of treatment tactics.
{"title":"Pro-inflammatory cytokines in patients with acute coronary syndrome","authors":"O. Smaliukh","doi":"10.24061/2413-0737.xxvi.2.102.2022.6","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.6","url":null,"abstract":"The pathogenesis of acute coronary syndrome is based on the processes of atherosclerosis of coronary arteries and atherothrombosis, accompanied by the destruction of non-stable atherosclerotic plaque coating and, in the future, by thrombosis. Myocardial ischemia initiates local and systemic inflammatory responses with the release of pro-inflammatory cytokines, which trigger a cascade of reactions, contributing to the more profound damage to cardiomyocytes. That is why it is extremely important to determine the activity of proinflammatory cytokines in patients with acute coronary syndrome.The aim of the work. To investigate the indices of pro-inflammatory cytokines in patients with acute coronary syndrome.Materials and Methods. 33 patients with acute coronary syndrome, namely with unstable angina pectoris, who underwent inpatient treatment in the cardiology department of the Lviv hospital for emergency medicine, were examined. The patients were 12 (36%) males and 21 (64%) females, with an average age of 68.5±2 years. The patients received treatment according to modern protocols for medical care for patients with acute coronary syndrome without ST-segment elevation and recommendations of the European Heart Association. The control group consisted of 20 practically healthy individuals of the same age and status. The patients were subjected to general clinical and instrumental examination methods, proinflammatory interleukins in serum enzyme-linked immunosorbent assay (on admission for hospital treatment).Results of the research. It was found that in patients with acute coronary syndrome, pro-inflammatory cytokines (interleukin-1β, interleukin-6, interleukin-17, tumor necrosis factor-alpha) exceed the values of almost healthy individuals by almost 2 times (p˂0.01).Conclusion. In patients with acute coronary syndrome, there is a significant (p˂0.01) increase in pro-inflammatory cytokines, which indicates the direct involvement of inflammation in the pathogenesis of the pathological process and requires appropriate correction of treatment tactics.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81489628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.13
N. Ryngach, L. Vlasyk, L. Vlasyk, T. Kolodnitska
The aim to conduct a content analysis of studies on the impacts of air pollution on the urban residents’ health in the world and Ukraine, to show the relationship between urbanization and the selected environmental risk factor, to assess its contribution to the global disease burden for Ukraine minimizing harmful effects.Material and methods: Content analysis of research on the air pollution exposure on the urban residents’ health in the world and Ukraine was used. The Data Visualizations / Institute for Health Metrics and Evaluation (IHME) hub data was used to study the contribution to the global burden of disease. GBD 2019 Cause and Risk Summary.Results: At present, changes in thinking and a synergistic approach are needed to fulfill all the goals of achieving the Sustainable Development Goals, approved, agreed and set by governments around the world, including Ukraine. Important Global Task 3.9 "Significantly reduce the number of deaths and illnesses from hazardous chemicals and air, water and soil pollution and poisoning", was not chosen by Ukraine due to a lack of reliable indicators with a proven cause-and-effect relationship with the environmental factor that caused this disorder. Reducing the level of air pollution can significantly reduce the burden of diseases, primarily those caused by heart disease and stroke, lung cancer, and chronic respiratory diseases, including asthma.Conclusions: Policies that encourage investment in cleaner transport, energyefficient homes, electricity generation, industry and better household waste management can reduce key sources of air pollution.
{"title":"Urbanization and health impacts of air pollution in Ukraine: threats and opportunities","authors":"N. Ryngach, L. Vlasyk, L. Vlasyk, T. Kolodnitska","doi":"10.24061/2413-0737.xxvi.2.102.2022.13","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.13","url":null,"abstract":"The aim to conduct a content analysis of studies on the impacts of air pollution on the urban residents’ health in the world and Ukraine, to show the relationship between urbanization and the selected environmental risk factor, to assess its contribution to the global disease burden for Ukraine minimizing harmful effects.Material and methods: Content analysis of research on the air pollution exposure on the urban residents’ health in the world and Ukraine was used. The Data Visualizations / Institute for Health Metrics and Evaluation (IHME) hub data was used to study the contribution to the global burden of disease. GBD 2019 Cause and Risk Summary.Results: At present, changes in thinking and a synergistic approach are needed to fulfill all the goals of achieving the Sustainable Development Goals, approved, agreed and set by governments around the world, including Ukraine. Important Global Task 3.9 \"Significantly reduce the number of deaths and illnesses from hazardous chemicals and air, water and soil pollution and poisoning\", was not chosen by Ukraine due to a lack of reliable indicators with a proven cause-and-effect relationship with the environmental factor that caused this disorder. Reducing the level of air pollution can significantly reduce the burden of diseases, primarily those caused by heart disease and stroke, lung cancer, and chronic respiratory diseases, including asthma.Conclusions: Policies that encourage investment in cleaner transport, energyefficient homes, electricity generation, industry and better household waste management can reduce key sources of air pollution.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89394251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.8
A. I. Shurma, F. Grynchuk
The aim to evaluate the possibility of determining the optical density of venous blood plasma (ODVBP) to identify the viability of the intestines in the experiment.Material and methods. For the study, 30 nonlinear white rats were used. In 10 animals, the loop of the middle part of the small intestine was tied with a ligature to simulate destruction, and in 10 animals, the loop of the middle part of the colon was ligated. After 12 h, a laparotomy was performed, the ligated loop of the intestine was removed for histological examination and blood was drawn from the jugular vein to measure ODVBP. The control was given to 10 healthy animals.Results. Healthy animals at a wavelength lambda = 310 nm found a specific maximum ODVBP, reaching 0.22 units (0.22 ± 0.01). After 12 h in animals with models of small bowel destruction, the ODVBP values at this wavelength were 0.38 ± 0.17 units, which was statistically significantly (p <0.01) higher than the control values. In animals with models of colon destruction, the indicators of ODVBP at this wavelength were 0.37 ± 0.13 units, which was statistically significantly (p <0.01) higher than the control values. There were no statistically significant differences between the indicators of animals with models of destruction of different parts of the intestine (p> 0.05). Necrotic changes of the intestinal wall were detected on all histological preparations.Conclusions. 1. According to experimental data, in healthy rats at a wavelength lambda = 310 nm, there is a peak ODVBP, reaching 0.22 ± 0.01 units. 2. In animals with models of destruction of the small intestine, the rate of ODVBP at this wavelength increases to 0.38 ± 0.17 units, and in animals with models of destruction of the colon - up to 0.37 ± 0.13 units, which is statistically significant (p (0.01), exceeds the control values, at the same time there are no statistically significant distinctions in different localization of intestinal destruction (p> 0.05). 3. The data obtained indicate the prospects for clinical use of such an index to assess the condition of the intestines under conditions of their destruction and the need for appropriate clinical trials.
{"title":"Experimental substantiation of estimating the optical density of venous blood plasma to determine intestinal viability","authors":"A. I. Shurma, F. Grynchuk","doi":"10.24061/2413-0737.xxvi.2.102.2022.8","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.8","url":null,"abstract":"The aim to evaluate the possibility of determining the optical density of venous blood plasma (ODVBP) to identify the viability of the intestines in the experiment.Material and methods. For the study, 30 nonlinear white rats were used. In 10 animals, the loop of the middle part of the small intestine was tied with a ligature to simulate destruction, and in 10 animals, the loop of the middle part of the colon was ligated. After 12 h, a laparotomy was performed, the ligated loop of the intestine was removed for histological examination and blood was drawn from the jugular vein to measure ODVBP. The control was given to 10 healthy animals.Results. Healthy animals at a wavelength lambda = 310 nm found a specific maximum ODVBP, reaching 0.22 units (0.22 ± 0.01). After 12 h in animals with models of small bowel destruction, the ODVBP values at this wavelength were 0.38 ± 0.17 units, which was statistically significantly (p <0.01) higher than the control values. In animals with models of colon destruction, the indicators of ODVBP at this wavelength were 0.37 ± 0.13 units, which was statistically significantly (p <0.01) higher than the control values. There were no statistically significant differences between the indicators of animals with models of destruction of different parts of the intestine (p> 0.05). Necrotic changes of the intestinal wall were detected on all histological preparations.Conclusions. 1. According to experimental data, in healthy rats at a wavelength lambda = 310 nm, there is a peak ODVBP, reaching 0.22 ± 0.01 units. 2. In animals with models of destruction of the small intestine, the rate of ODVBP at this wavelength increases to 0.38 ± 0.17 units, and in animals with models of destruction of the colon - up to 0.37 ± 0.13 units, which is statistically significant (p (0.01), exceeds the control values, at the same time there are no statistically significant distinctions in different localization of intestinal destruction (p> 0.05). 3. The data obtained indicate the prospects for clinical use of such an index to assess the condition of the intestines under conditions of their destruction and the need for appropriate clinical trials.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74162473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.14
A. Biduchak
The main specific signs and types of conflict in medicine between a doctor and patient in the system of theoretical and legal relations are analyzed and determined. The main views on the concept of "imperfect work of medical specialists", which is an infringement of standards of medical ethics and medical rights in rendering medical services are shown.Conclusions. The main specific signs and types of conflict that influence the relationship between doctor and patient are identified. The creation of a legal and information base for the adjustment and settlement of conflicts in the medical field is an urgent state need which will favour an increase in patients' confidence in the health care system.
{"title":"Doctor and patient: two parties of one conflict","authors":"A. Biduchak","doi":"10.24061/2413-0737.xxvi.2.102.2022.14","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.14","url":null,"abstract":"The main specific signs and types of conflict in medicine between a doctor and patient in the system of theoretical and legal relations are analyzed and determined. The main views on the concept of \"imperfect work of medical specialists\", which is an infringement of standards of medical ethics and medical rights in rendering medical services are shown.Conclusions. The main specific signs and types of conflict that influence the relationship between doctor and patient are identified. The creation of a legal and information base for the adjustment and settlement of conflicts in the medical field is an urgent state need which will favour an increase in patients' confidence in the health care system.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"62 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79768588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.7
V. Fik, I. Savka, R. Matkivska, Z. Z. Masna, Y. Paltov
Peculiarities of pathomorphological changes of periodontal components of rats under the long-term opioid influence during twelve weeks in the experiment have been studied.Objective – to determine the features of structural changes in the tissues of the periodontal complex of rats under conditions of long-term experimental action of opioids for twelve weeks.Methods. Adult male rats were administered the opioid analgesic nalbuphine for 12 weeks, in gradually increasing doses every 2 weeks. The initial dose was 0.212 mg / kg, 11-12 weeks - 0.3 mg / kg. Components of the dental organ of the upper and lower jaws of rats were used as material for histological examination. Sampling was performed at the end of week 12 of the experiment.Results. On histological preparations in the epithelium of the gums thinning, ulcers, desquamation, as well as the presence of areas of necrosis and inflammatory infiltrates were determined. Microscopic examinations of the epithelium of the free part of the gums in the gingival sulcus revealed foci of necrosis, accumulation of purulent bodies, damage to the epithelium of attachment and defragmentation of circular periodontal fibers, which led to the formation of periodontal pockets. Destruction of collagen fibers, purulent bodies, fibrinoid edema and fibrinoid necrosis were noted in the own plate. In the constituent components of the periodontium, the destruction of fibers with detachment from the connective tissue membrane of the dental cell, as well as signs of mucoid edema were determined. In the connective tissue of the periodontium observed thrombosis and stasis due to the coordination of blood cells, excessive proliferation of microvessels, diapedetic hemorrhage, which led to the progression of hypoxia.Conclusions. The experimental action of the opioid for 12 weeks revealed alternative changes, which were due to the deepening of dystrophy, necrosis of the soft tissues of the periodontium and severe hemomicrocirculation. Diffuse progression of the inflammatory-dystrophic process was due to insufficient activity of reparative processes, which indicated the irreversible nature of changes in the periodontium, which developed against the background of chronic opioid exposure.
{"title":"Morphological reorganization of periodontic tissues under experimental opioid influence for twelve weeks","authors":"V. Fik, I. Savka, R. Matkivska, Z. Z. Masna, Y. Paltov","doi":"10.24061/2413-0737.xxvi.2.102.2022.7","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.7","url":null,"abstract":"Peculiarities of pathomorphological changes of periodontal components of rats under the long-term opioid influence during twelve weeks in the experiment have been studied.Objective – to determine the features of structural changes in the tissues of the periodontal complex of rats under conditions of long-term experimental action of opioids for twelve weeks.Methods. Adult male rats were administered the opioid analgesic nalbuphine for 12 weeks, in gradually increasing doses every 2 weeks. The initial dose was 0.212 mg / kg, 11-12 weeks - 0.3 mg / kg. Components of the dental organ of the upper and lower jaws of rats were used as material for histological examination. Sampling was performed at the end of week 12 of the experiment.Results. On histological preparations in the epithelium of the gums thinning, ulcers, desquamation, as well as the presence of areas of necrosis and inflammatory infiltrates were determined. Microscopic examinations of the epithelium of the free part of the gums in the gingival sulcus revealed foci of necrosis, accumulation of purulent bodies, damage to the epithelium of attachment and defragmentation of circular periodontal fibers, which led to the formation of periodontal pockets. Destruction of collagen fibers, purulent bodies, fibrinoid edema and fibrinoid necrosis were noted in the own plate. In the constituent components of the periodontium, the destruction of fibers with detachment from the connective tissue membrane of the dental cell, as well as signs of mucoid edema were determined. In the connective tissue of the periodontium observed thrombosis and stasis due to the coordination of blood cells, excessive proliferation of microvessels, diapedetic hemorrhage, which led to the progression of hypoxia.Conclusions. The experimental action of the opioid for 12 weeks revealed alternative changes, which were due to the deepening of dystrophy, necrosis of the soft tissues of the periodontium and severe hemomicrocirculation. Diffuse progression of the inflammatory-dystrophic process was due to insufficient activity of reparative processes, which indicated the irreversible nature of changes in the periodontium, which developed against the background of chronic opioid exposure.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86284133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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