Pub Date : 2022-12-20DOI: 10.24061/2413-0737.xxvi.2.102.2022.2
D. Hontsariuk, K. Ferfetska, L. Pits, A. Kravchuk
Aim of the study. To investigate the features of the clinical course of chronic pancreatitis in comorbidity with ischemic heart disease.Research methods. We used a survey, anamnesis, objective examination, biochemical, radioimmune (indicators of insulin in the blood), instrumental (sonographic, ECG), statistical (computer analysis of data). The criteria for inclusion in chronic pancreatitis were exacerbations, abdominal pain and dyspeptic syndrome, sonographic changes in the pancreas, risk factors, patient consent for the study. The criteria for inclusion in ischemic heart disease were stable exertional angina FC I-II, CHF IIA-B, FC II-III (NYHA) in the absence of angina attacks within 3 months; regular treatment for 3 months, patient's consent. The exclusion criteria included oncological diseases, acute exacerbations of CP, myocardial infarction in the last 3 months, chronic kidney disease, and diabetes mellitus. The study was carried out in accordance with the Order of the Ministry of Health of Ukraine No.281 dated 1.11.2000. The study guidance and informed consent form were approved by the Commission on Biomedical Ethics of Bukovina State Medical University.Results. The aggravating nature of the course of the disease, the polymorphism of clinical symptoms, especially the pain syndrome, which did not always have a clear localization, irradiation, intensity and was absent in about 15%, was established. The atypical course in 83.3% of cases was associated with diseases of the digestive system. In 70.0% of patients, atherosclerotic changes in the vessels of the abdominal cavity were revealed, in 47.5% of them, lesions of the carotid artery at the stage of atheromatous plaque or its atherothrombosis, stenosis of the vascular lumen and hemodynamic disturbances were diagnosed. There was a tendency to a decrease in the ejection fraction, cardiac and stroke volumes against the background of an increase in the end systolic volume (ESV), end diastolic volume (EDV) with an EF of 50.4 ± 2.3%.Conclusion. The clinical course of chronic pancreatitis in comorbidity with ischemic heart disease is characterized by prolonged formation (more than 10 years), accompanied by structural and morphological changes in the pancreas of a fibrosing nature, the presence of atherosclerotic changes in the carotid arteries, atherosclerotic lesions of the aorta, mesenteric dysfunction, diastolic course, the possibility of premature fatal cardiovascular problems and the association with concomitant gastroenterological diseases.
{"title":"Features of clinical and sonographic symptoms in chronic pancreatitis with ischemic heart disease","authors":"D. Hontsariuk, K. Ferfetska, L. Pits, A. Kravchuk","doi":"10.24061/2413-0737.xxvi.2.102.2022.2","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.2.102.2022.2","url":null,"abstract":"Aim of the study. To investigate the features of the clinical course of chronic pancreatitis in comorbidity with ischemic heart disease.Research methods. We used a survey, anamnesis, objective examination, biochemical, radioimmune (indicators of insulin in the blood), instrumental (sonographic, ECG), statistical (computer analysis of data). The criteria for inclusion in chronic pancreatitis were exacerbations, abdominal pain and dyspeptic syndrome, sonographic changes in the pancreas, risk factors, patient consent for the study. The criteria for inclusion in ischemic heart disease were stable exertional angina FC I-II, CHF IIA-B, FC II-III (NYHA) in the absence of angina attacks within 3 months; regular treatment for 3 months, patient's consent. The exclusion criteria included oncological diseases, acute exacerbations of CP, myocardial infarction in the last 3 months, chronic kidney disease, and diabetes mellitus. The study was carried out in accordance with the Order of the Ministry of Health of Ukraine No.281 dated 1.11.2000. The study guidance and informed consent form were approved by the Commission on Biomedical Ethics of Bukovina State Medical University.Results. The aggravating nature of the course of the disease, the polymorphism of clinical symptoms, especially the pain syndrome, which did not always have a clear localization, irradiation, intensity and was absent in about 15%, was established. The atypical course in 83.3% of cases was associated with diseases of the digestive system. In 70.0% of patients, atherosclerotic changes in the vessels of the abdominal cavity were revealed, in 47.5% of them, lesions of the carotid artery at the stage of atheromatous plaque or its atherothrombosis, stenosis of the vascular lumen and hemodynamic disturbances were diagnosed. There was a tendency to a decrease in the ejection fraction, cardiac and stroke volumes against the background of an increase in the end systolic volume (ESV), end diastolic volume (EDV) with an EF of 50.4 ± 2.3%.Conclusion. The clinical course of chronic pancreatitis in comorbidity with ischemic heart disease is characterized by prolonged formation (more than 10 years), accompanied by structural and morphological changes in the pancreas of a fibrosing nature, the presence of atherosclerotic changes in the carotid arteries, atherosclerotic lesions of the aorta, mesenteric dysfunction, diastolic course, the possibility of premature fatal cardiovascular problems and the association with concomitant gastroenterological diseases.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84715117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.4
N. M. Kulaiets
Resume. The relevance of the problem of chronic heart failure (CHF) for doctors in many countries remains in the leading positions and is due to the prevalence of the pathology and significant economic losses - the severity of the course of the disease, the need for hospitalization and a significant level of mortality.The purpose. To study indicators of lipid and electrolyte metabolism, the level of NT-pro BNP in patients with heart failure and atrial fibrillation.Material and methods. 100 patients aged 45-65 were examined. All patients were divided into groups: Group I – patients with HF with sinus rhythm or atrial fibrillation (AF) (permanent or persistent form), (n=50). II group - patients without HF with AF, (n=50). III – control group: 36 practically healthy people. All patients underwent a clinical examination, blood lipid profile, determination of NT-proBNP level by immunoenzymatic method, ECG, echocardiography (ECHOKG).Research results. The analysis of the lipid profile of the examined patients indicates a violation of lipid metabolism, the development of dyslipidemia, which is an important risk factor and progression of coronary heart disease (CHD). The results of electrolyte exchange indicate the existence of significant differences in the levels of K+, Mg2+ Na+ in the blood serum of healthy and CHF patients. There was a probable difference in the direction of a decrease in the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF in comparison with healthy ones. In addition, the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF were probably lower than in patients with CHF with sinus rhythm. Indicators of NT-pro BNP level in patients with CHF and AF were significantly higher (p<0.05) than similar parameters in patients without CHF with AF.Conclusions. Violations of the lipid spectrum of the blood were detected, which indicates the progression of coronary heart disease and is a predictor of an unfavorable prognosis in patients with chronic heart failure. There was a probable difference in the direction of a decrease in the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF compared to healthy people. Levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF were probably lower than in patients with CHF with sinus rhythm. An increase in the level of NT-proBNP was found in patients with HF and AF compared to patients with HF and sinus rhythm.
{"title":"Features of lipid and electrolyte metabolism indicators, NT-pro BNP level in patients with heart failure and atrial fibrillation","authors":"N. M. Kulaiets","doi":"10.24061/2413-0737.xxvi.4.104.2022.4","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.4","url":null,"abstract":"Resume. The relevance of the problem of chronic heart failure (CHF) for doctors in many countries remains in the leading positions and is due to the prevalence of the pathology and significant economic losses - the severity of the course of the disease, the need for hospitalization and a significant level of mortality.The purpose. To study indicators of lipid and electrolyte metabolism, the level of NT-pro BNP in patients with heart failure and atrial fibrillation.Material and methods. 100 patients aged 45-65 were examined. All patients were divided into groups: Group I – patients with HF with sinus rhythm or atrial fibrillation (AF) (permanent or persistent form), (n=50). II group - patients without HF with AF, (n=50). III – control group: 36 practically healthy people. All patients underwent a clinical examination, blood lipid profile, determination of NT-proBNP level by immunoenzymatic method, ECG, echocardiography (ECHOKG).Research results. The analysis of the lipid profile of the examined patients indicates a violation of lipid metabolism, the development of dyslipidemia, which is an important risk factor and progression of coronary heart disease (CHD). The results of electrolyte exchange indicate the existence of significant differences in the levels of K+, Mg2+ Na+ in the blood serum of healthy and CHF patients. There was a probable difference in the direction of a decrease in the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF in comparison with healthy ones. In addition, the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF were probably lower than in patients with CHF with sinus rhythm. Indicators of NT-pro BNP level in patients with CHF and AF were significantly higher (p<0.05) than similar parameters in patients without CHF with AF.Conclusions. Violations of the lipid spectrum of the blood were detected, which indicates the progression of coronary heart disease and is a predictor of an unfavorable prognosis in patients with chronic heart failure. There was a probable difference in the direction of a decrease in the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF compared to healthy people. Levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF were probably lower than in patients with CHF with sinus rhythm. An increase in the level of NT-proBNP was found in patients with HF and AF compared to patients with HF and sinus rhythm.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"347 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84858136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.6
S. Sazhyn
The COVID-19 pandemic has been going on for 2.5 years, which is a serious challenge for the health care systems of most countries of the world. The high frequency of mutations of the SARS-CoV-2 changes the epidemiological characteristics, clinical manifestations of the disease, as well as consequences after infection.Aim of the study. To conduct an analysis of the clinical and paraclinical features of the course of COVID-19 in primary school-age children, taking into account gender, to improve the prognosis of the severity and duration of the disease, to optimize the tactics of managing patients.Materials and methods. 55 clinical cases of COVID-19 in primary school-age patients were analyzed. The gender of the patients was considered a group-forming feature. The obtained results were analyzed by methods of descriptive statistics biostatistics, and clinical epidemiology.Results. It was established that half of the male patients and 44.4% of the girls had registered complications of the main disease, mainly in the form of acute respiratory failure. The onset of the disease was characterized by general weakness and fever. Cough was more likely to be noted among boys, while in girls, there was a tendency to increase the frequency of complaints of nasal congestion. In the hospital, during the physical examination, the pathological sounds under the lungs during auscultation were registered significantly more common in male patients (75.0±8.2 versus 48.1±9.6%, Рφ < 0,05). Male gender, residence in the cities, violation in vaccination schedule, dyspnea, the level of blood oxygen saturation below 95% during hospitalization are characterized with a high predictive value of a longer hospitalization period.Conclusion. The course of COVID-19 in primary school-aged children was not dependent on gender and was multisymptomatic, however, the average duration of hospitalization was significantly higher among male patients. Incomplete vaccination status increased the attributive relative risks of more bed days in the hospital with an odds ratio of 6.7:1.
COVID-19大流行已经持续了两年半，这对世界上大多数国家的卫生保健系统构成了严重挑战。SARS-CoV-2的高突变频率改变了该病的流行病学特征、临床表现以及感染后的后果。研究的目的。分析考虑性别因素的小学学龄儿童新冠肺炎病程的临床和临床旁特征，改善病情严重程度和病程的预后，优化患者管理策略。材料和方法。分析55例小学学龄患者新冠肺炎临床病例。患者的性别被认为是群体形成的特征。采用描述统计学、生物统计学和临床流行病学方法对所得结果进行分析。经证实，一半的男性患者和44.4%的女孩患有主要疾病的并发症，主要表现为急性呼吸衰竭。发病的特点是全身虚弱和发烧。咳嗽在男孩中更容易被注意到，而在女孩中，鼻塞的抱怨频率有增加的趋势。在医院体检时，男性患者听诊时肺下病理性音较多(75.0±8.2 vs 48.1±9.6%，Рφ < 0.05)。男性、城市居住、违反疫苗接种计划、呼吸困难、住院期间血氧饱和度低于95%对延长住院时间具有较高的预测价值。小学学龄儿童的病程不依赖于性别，具有多症状性，但男性患者的平均住院时间明显高于男性患者。不完整的疫苗接种状况增加了住院天数较多的归因相对风险，优势比为6.7:1。
{"title":"Clinical and paraclinical features of the course of infection caused by SARS-CoV-2 in primary school-age children depending on gender","authors":"S. Sazhyn","doi":"10.24061/2413-0737.xxvi.4.104.2022.6","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.6","url":null,"abstract":"The COVID-19 pandemic has been going on for 2.5 years, which is a serious challenge for the health care systems of most countries of the world. The high frequency of mutations of the SARS-CoV-2 changes the epidemiological characteristics, clinical manifestations of the disease, as well as consequences after infection.Aim of the study. To conduct an analysis of the clinical and paraclinical features of the course of COVID-19 in primary school-age children, taking into account gender, to improve the prognosis of the severity and duration of the disease, to optimize the tactics of managing patients.Materials and methods. 55 clinical cases of COVID-19 in primary school-age patients were analyzed. The gender of the patients was considered a group-forming feature. The obtained results were analyzed by methods of descriptive statistics biostatistics, and clinical epidemiology.Results. It was established that half of the male patients and 44.4% of the girls had registered complications of the main disease, mainly in the form of acute respiratory failure. The onset of the disease was characterized by general weakness and fever. Cough was more likely to be noted among boys, while in girls, there was a tendency to increase the frequency of complaints of nasal congestion. In the hospital, during the physical examination, the pathological sounds under the lungs during auscultation were registered significantly more common in male patients (75.0±8.2 versus 48.1±9.6%, Рφ < 0,05). Male gender, residence in the cities, violation in vaccination schedule, dyspnea, the level of blood oxygen saturation below 95% during hospitalization are characterized with a high predictive value of a longer hospitalization period.Conclusion. The course of COVID-19 in primary school-aged children was not dependent on gender and was multisymptomatic, however, the average duration of hospitalization was significantly higher among male patients. Incomplete vaccination status increased the attributive relative risks of more bed days in the hospital with an odds ratio of 6.7:1.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90233100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.9
A. Biduchak
Medical practice confirms that in the conditions of health care reform, conflict occupies a special place in any team. This is because conflict is an integral part of life. Therefore, it is necessary to study in depth the way of formation of modern organizational conflict, the way of eliminating the conflict and the way of fighting its consequences. At the same time, the most important result of effective enterprise conflict management will be the formation of a mechanism for early warning of conflict situations and mechanisms for resolving medical conflicts.The purpose of the study was conflicts in the field of health care in the «doctor-patient» system. Materials and methods. The study of conflict in the team was conducted using medical and sociological methods using an anonymous questionnaire developed by us. The study involved 582 health workers, including 231 men and 351 women. The age composition of medical workers: from 18 and older.Results and discussion. A study was conducted aimed at identifying the socio-psychological causes of conflicts and methods of their resolution in the health care organization using the example of medical personnel. The main causes, frequency of occurrence and types of conflict situations in medical teams are analyzed. Based on the conducted sociological research, it was established that the largest number of conflicts (32.1%) occurs in the «doctor-patient relatives» system, and about 25% - in the «doctor-patient» system. The behavior of medical personnel during the conflict was analyzed using practical examples. It was found that the majority (34%) of respondents do not intervene in the conflict and take a neutral position.Conclusions. The study confirmed the hypothesis that the process of conflict management will be more effective when the situation in the organization of processes as a whole in a medical institution changes. Diagnosis and management of a medical conflict should be the key to the successful operation of a medical institution, thanks to the creation of a working atmosphere for the medical team and the patient, where everyone will feel comfortable and work for maximum results.
{"title":"Analysis of the emergence of conflicts in the doctor-patient system","authors":"A. Biduchak","doi":"10.24061/2413-0737.xxvi.4.104.2022.9","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.9","url":null,"abstract":"Medical practice confirms that in the conditions of health care reform, conflict occupies a special place in any team. This is because conflict is an integral part of life. Therefore, it is necessary to study in depth the way of formation of modern organizational conflict, the way of eliminating the conflict and the way of fighting its consequences. At the same time, the most important result of effective enterprise conflict management will be the formation of a mechanism for early warning of conflict situations and mechanisms for resolving medical conflicts.The purpose of the study was conflicts in the field of health care in the «doctor-patient» system. \u0000Materials and methods. The study of conflict in the team was conducted using medical and sociological methods using an anonymous questionnaire developed by us. The study involved 582 health workers, including 231 men and 351 women. The age composition of medical workers: from 18 and older.Results and discussion. A study was conducted aimed at identifying the socio-psychological causes of conflicts and methods of their resolution in the health care organization using the example of medical personnel. The main causes, frequency of occurrence and types of conflict situations in medical teams are analyzed. Based on the conducted sociological research, it was established that the largest number of conflicts (32.1%) occurs in the «doctor-patient relatives» system, and about 25% - in the «doctor-patient» system. The behavior of medical personnel during the conflict was analyzed using practical examples. It was found that the majority (34%) of respondents do not intervene in the conflict and take a neutral position.Conclusions. The study confirmed the hypothesis that the process of conflict management will be more effective when the situation in the organization of processes as a whole in a medical institution changes. Diagnosis and management of a medical conflict should be the key to the successful operation of a medical institution, thanks to the creation of a working atmosphere for the medical team and the patient, where everyone will feel comfortable and work for maximum results.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"42 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77308338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.12
B.V. Horban
As of January 2021, 87.6 million cases of COVID-19 have been registered in the world, of which 1.9 million cases have resulted in death. In Ukraine, at the end of 2020, the number of cases of the disease was 1,099,493, of which 19,505 resulted in death. The progressive course of COVID-19 can induce severe damage to the lungs, kidneys, heart and other organs and systems with the formation of acute respiratory distress syndrome and multiple organ failure syndrome. Kidney damage in the case of COVID-19 is still considered to be mainly secondary and associated with hypoxia, ischemia, disseminated intravascular coagulation in the case of severe and extremely severe disease. However, it is worth noting that kidney damage also occurs against the background of the massive use of medications that are sufficiently nephrotoxic.The purpose of this work is to review scientific results, which contain information about the current state of the problem of kidney damage in patients who have contracted the coronavirus disease.Patients with chronic kidney disease have an increased risk of infection with COVID-19, its severe course and mortality. Endothelial dysfunction, microangiopathy, coagulation disorders, and imbalance of the renin-angiotensin-aldosterone system are key links to kidney damage in the case of such concomitant pathology. An increase in the level of serum creatinine and blood urea nitrogen, the appearance and increase in the level of hematuria and proteinuria - these changes require careful study.Conclusions. 1. To date, scientific data on the mechanisms of kidney damage in patients with COVID-19 have been expanded. This makes it possible to develop methods of timely drug exposure to prevent the progression of renal function decline. 2. The incidence of acute kidney injury and mortality in COVID-19 patients with CKD is significantly higher than without CKD. 3. After recovery from COVID-19, patients with CKD should have dispensary observation and treatment.
{"title":"Kidney injury in patients who have contracted coronavirus disease: status of the problem today","authors":"B.V. Horban","doi":"10.24061/2413-0737.xxvi.4.104.2022.12","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.12","url":null,"abstract":"As of January 2021, 87.6 million cases of COVID-19 have been registered in the world, of which 1.9 million cases have resulted in death. In Ukraine, at the end of 2020, the number of cases of the disease was 1,099,493, of which 19,505 resulted in death. The progressive course of COVID-19 can induce severe damage to the lungs, kidneys, heart and other organs and systems with the formation of acute respiratory distress syndrome and multiple organ failure syndrome. Kidney damage in the case of COVID-19 is still considered to be mainly secondary and associated with hypoxia, ischemia, disseminated intravascular coagulation in the case of severe and extremely severe disease. However, it is worth noting that kidney damage also occurs against the background of the massive use of medications that are sufficiently nephrotoxic.The purpose of this work is to review scientific results, which contain information about the current state of the problem of kidney damage in patients who have contracted the coronavirus disease.Patients with chronic kidney disease have an increased risk of infection with COVID-19, its severe course and mortality. Endothelial dysfunction, microangiopathy, coagulation disorders, and imbalance of the renin-angiotensin-aldosterone system are key links to kidney damage in the case of such concomitant pathology. An increase in the level of serum creatinine and blood urea nitrogen, the appearance and increase in the level of hematuria and proteinuria - these changes require careful study.Conclusions. 1. To date, scientific data on the mechanisms of kidney damage in patients with COVID-19 have been expanded. This makes it possible to develop methods of timely drug exposure to prevent the progression of renal function decline. 2. The incidence of acute kidney injury and mortality in COVID-19 patients with CKD is significantly higher than without CKD. 3. After recovery from COVID-19, patients with CKD should have dispensary observation and treatment.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76153339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.5
I. Kuchyn, V. Horoshko
Considering the war situation in Ukraine, the treatment of pain in patients with mine blast injuries is of great importance in today's medical practice because, during the Anti-Terrorist Operation/Joint Forces Operation, such injuries account for more than 25%, and chronic pain after such injuries is diagnosed in 83.3% of cases. Such injuries are characterized by significant damage. Data on pain treatment at the stage of treatment in military medical clinical centers are scarce.The goal of the work. To investigate the results of pain treatment of patients with mine blast wounds at the stage of treatment in military medical clinical centers of the Armed Forces of Ukraine.Methods. Data on the treatment of 280 patients with mine blast injuries are presented. Pain intensity was diagnosed using a visual analog scale. The Shapiro-Wilk test was used to check the distribution of quantitative indicators for normality. The distribution law differed from the normal one; the median value (Me) and the interquartile range (QI-QIII) were given to represent quantitative indicators. The comparison of indicators in two groups was carried out according to the Mann-Whitney test. To analyze the dynamics of the indicators, the Friedman test for related samples was used, the posterior comparison was carried out using the Bonferroni correction. For qualitative indicators, the absolute frequency of symptom manifestation and the relative frequency (%) are presented, and for the comparison of two groups, the chi-square test was used, taking into account the correction for continuity. When conducting the analysis in all cases, the critical significance level was equal to 0.05.Results. Pain intensity according to VAS before analgesia at the stage of treatment in military medical clinical centers shows that before analgesia in group 2 it was significantly higher than in patients of group 1 (p<0.001) and is 7 points – severe pain. Patients of group 1 experienced pain of average intensity on admission - 4 points. After analgesia, the average value of the VAS indicator in the two groups was practically not different, but it was statistically significant (p=0.012), this indicator was higher in group 2. During in-patient observation for 2-6 days (p<0.001) and before discharge from in-patient treatment (p=0.013) values of the VAS indicator in group 2 were higher than in group 1. The dynamics of the intervals between analgesia indicate that in groups 1 and 2 there is a statistically significant difference during the 1 day of observation (p=0.005) and 9-14 days of observation (p<0.001).Conclusions. Taking into account the obtained data, it is clear that the effectiveness of analgesia, both in the previous stages of treatment and during the transportation of patients, was at a low level. It is also worth noting that during discharge from inpatient treatment, patients still felt mild pain. Patients with mine blast injuries have a high risk of chronic pain. The obtained results of the s
{"title":"Treatment of pain in patients with mine blast wounds during treatment in military medical clinical centers","authors":"I. Kuchyn, V. Horoshko","doi":"10.24061/2413-0737.xxvi.4.104.2022.5","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.5","url":null,"abstract":"Considering the war situation in Ukraine, the treatment of pain in patients with mine blast injuries is of great importance in today's medical practice because, during the Anti-Terrorist Operation/Joint Forces Operation, such injuries account for more than 25%, and chronic pain after such injuries is diagnosed in 83.3% of cases. Such injuries are characterized by significant damage. Data on pain treatment at the stage of treatment in military medical clinical centers are scarce.The goal of the work. To investigate the results of pain treatment of patients with mine blast wounds at the stage of treatment in military medical clinical centers of the Armed Forces of Ukraine.Methods. Data on the treatment of 280 patients with mine blast injuries are presented. Pain intensity was diagnosed using a visual analog scale. The Shapiro-Wilk test was used to check the distribution of quantitative indicators for normality. The distribution law differed from the normal one; the median value (Me) and the interquartile range (QI-QIII) were given to represent quantitative indicators. The comparison of indicators in two groups was carried out according to the Mann-Whitney test. To analyze the dynamics of the indicators, the Friedman test for related samples was used, the posterior comparison was carried out using the Bonferroni correction. For qualitative indicators, the absolute frequency of symptom manifestation and the relative frequency (%) are presented, and for the comparison of two groups, the chi-square test was used, taking into account the correction for continuity. When conducting the analysis in all cases, the critical significance level was equal to 0.05.Results. Pain intensity according to VAS before analgesia at the stage of treatment in military medical clinical centers shows that before analgesia in group 2 it was significantly higher than in patients of group 1 (p<0.001) and is 7 points – severe pain. Patients of group 1 experienced pain of average intensity on admission - 4 points. After analgesia, the average value of the VAS indicator in the two groups was practically not different, but it was statistically significant (p=0.012), this indicator was higher in group 2. During in-patient observation for 2-6 days (p<0.001) and before discharge from in-patient treatment (p=0.013) values of the VAS indicator in group 2 were higher than in group 1. The dynamics of the intervals between analgesia indicate that in groups 1 and 2 there is a statistically significant difference during the 1 day of observation (p=0.005) and 9-14 days of observation (p<0.001).Conclusions. Taking into account the obtained data, it is clear that the effectiveness of analgesia, both in the previous stages of treatment and during the transportation of patients, was at a low level. It is also worth noting that during discharge from inpatient treatment, patients still felt mild pain. Patients with mine blast injuries have a high risk of chronic pain. The obtained results of the s","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74266543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.1
A. Broniuk
The aim. To assess the functional state of the kidneys in patients with acute myocardial infarction and to determine the effect of reduced glomerular filtration rate on the course of the disease.Material and methods. A retrospective analysis of 410 medical records of patients who were treated for STEMI in the department for patients with myocardial infarction of the Vinnytsia Regional Clinical Medical and Diagnostic Center for Cardiovascular Pathology in 2019 was conducted. All patients were hospitalized within 12 hours of the onset of pain, all patients underwent urgent revascularization of the infarct-related artery. The average age of the examined was 64.8±0.4 years. There were 263 men (64.1%), average age 60.8±0.2 years and 147 women (35.9%), average age 68.8±0.5 years. Results. It was found that the average level of creatinine was 101.5±2.2 μmol/l, no significant difference between men and women was found. The level of GFR was 64.8±1.1 ml/min/1.73m2 and was significantly lower among women than men (p<0.001). GFR ≥90 ml/min/1.73m2 was diagnosed in 31 patients (7.5%), no significant difference between men and women was established. GFR 60-89 ml/min/1.73m2 was found in 206 people (50.2%), significantly more often among men than among women (p<0.001). GFR of 30-59 ml/min/1.73m2 was established in 160 patients (39.1%), significantly more often among women than men (p<0.001). 11 people (2.7%) had GFR within 15-29 ml/min/1.73m2, no difference was noted between men and women. Significantly more patients with Killip III were in the II group (p<0.001), and with Killip IV (p<0.001). Among the medical records of the deceased that we analyzed were 28 patients (6.8%). A significantly larger number of patients who died were among patients with GFR less than 60 ml/min/1.73m2, namely 24 people (13.8%), p<0.001.Conclusions. It was established that in STEMI patients who underwent urgent revascularization, the average level of GFR was 64.8±1.1 ml/min/1.73m2. 173 people (42.2%) had a decrease in GFR of less than 60 ml/min/1.73m2. A decrease in GFR was significantly more often diagnosed in women than in men (p≤0.001), women were significantly older than men (p≤0.001). In the group of patients with GFR less than 60 ml/min/1.73m2, there were significantly more patients with hypertension for more than 10 years (p≤0.001) and diabetes for more than 10 years (p=0.067), there were significantly more people with peripheral artery disease (p=0.017). In the group of patients with STEMI and GFR less than 60 ml/min/1.73m2, significantly more HF of high gradations (Killip III-IV) were detected - in 36 people (20.7%). In-hospital mortality was significantly higher in patients with reduced GFR, 2% and 13.8%, respectively, p<0.001.
{"title":"Functional state of kidneys in patients with acute myocardial infarction","authors":"A. Broniuk","doi":"10.24061/2413-0737.xxvi.4.104.2022.1","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.1","url":null,"abstract":"The aim. To assess the functional state of the kidneys in patients with acute myocardial infarction and to determine the effect of reduced glomerular filtration rate on the course of the disease.Material and methods. A retrospective analysis of 410 medical records of patients who were treated for STEMI in the department for patients with myocardial infarction of the Vinnytsia Regional Clinical Medical and Diagnostic Center for Cardiovascular Pathology in 2019 was conducted. All patients were hospitalized within 12 hours of the onset of pain, all patients underwent urgent revascularization of the infarct-related artery. The average age of the examined was 64.8±0.4 years. There were 263 men (64.1%), average age 60.8±0.2 years and 147 women (35.9%), average age 68.8±0.5 years. Results. It was found that the average level of creatinine was 101.5±2.2 μmol/l, no significant difference between men and women was found. The level of GFR was 64.8±1.1 ml/min/1.73m2 and was significantly lower among women than men (p<0.001). GFR ≥90 ml/min/1.73m2 was diagnosed in 31 patients (7.5%), no significant difference between men and women was established. GFR 60-89 ml/min/1.73m2 was found in 206 people (50.2%), significantly more often among men than among women (p<0.001). GFR of 30-59 ml/min/1.73m2 was established in 160 patients (39.1%), significantly more often among women than men (p<0.001). 11 people (2.7%) had GFR within 15-29 ml/min/1.73m2, no difference was noted between men and women. Significantly more patients with Killip III were in the II group (p<0.001), and with Killip IV (p<0.001). Among the medical records of the deceased that we analyzed were 28 patients (6.8%). A significantly larger number of patients who died were among patients with GFR less than 60 ml/min/1.73m2, namely 24 people (13.8%), p<0.001.Conclusions. It was established that in STEMI patients who underwent urgent revascularization, the average level of GFR was 64.8±1.1 ml/min/1.73m2. 173 people (42.2%) had a decrease in GFR of less than 60 ml/min/1.73m2. A decrease in GFR was significantly more often diagnosed in women than in men (p≤0.001), women were significantly older than men (p≤0.001). In the group of patients with GFR less than 60 ml/min/1.73m2, there were significantly more patients with hypertension for more than 10 years (p≤0.001) and diabetes for more than 10 years (p=0.067), there were significantly more people with peripheral artery disease (p=0.017). In the group of patients with STEMI and GFR less than 60 ml/min/1.73m2, significantly more HF of high gradations (Killip III-IV) were detected - in 36 people (20.7%). In-hospital mortality was significantly higher in patients with reduced GFR, 2% and 13.8%, respectively, p<0.001.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83860047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.11
S. Biletskyi, O. Petrynych, T. Kazantseva
Literature data on the role of the renin-angiotensin-aldosterone system in the pathogenesis of arterial hypertension and the role of angiotensin-converting enzyme inhibitors in the treatment of hypertension have been given.The renin-angiotensin-aldosterone system is the central element in controlling the body's water-salt balance and blood pressure. The main effector link of the renin-angiotensin system is angiotensin II, which causes vasospasm, activates heart contraction, inhibits the production of bradykinin, promotes proliferation, and fibrosis of blood vessels and myocardium, and promotes the synthesis of aldosterone in the glomerular zone of the adrenal cortex.Angiotensin-converting enzyme inhibitors are the mainstay of the treatment of arterial hypertension. They contribute to the correction of hypertension, hypertrophy, remodeling of the left ventricle, endothelial dysfunction, proliferation of arterial smooth muscles, and thrombotic phenomena. The 2018 ESH/ESC guidelines state that the first-line therapy in most patients with hypertension should be a fixed combination of a renin-angiotensin system blocker and a calcium channel blocker or diuretic. Blockade of the renin-angiotensin-aldosterone system is currently considered a gold standard of antihypertensive therapy.The objective is to systematize modern literature data on the role of ACE inhibitors in the treatment of arterial hypertension. Conclusion. To date, the concept of the role of the renin-angiotensin-aldosterone system (RAАS) in the pathogenesis of arterial hypertension and the role of ACE inhibitors in the treatment of hypertension has been formulated.
{"title":"Ace inhibitors in the treatment of arterial hypertension (literature review)","authors":"S. Biletskyi, O. Petrynych, T. Kazantseva","doi":"10.24061/2413-0737.xxvi.4.104.2022.11","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.11","url":null,"abstract":"Literature data on the role of the renin-angiotensin-aldosterone system in the pathogenesis of arterial hypertension and the role of angiotensin-converting enzyme inhibitors in the treatment of hypertension have been given.The renin-angiotensin-aldosterone system is the central element in controlling the body's water-salt balance and blood pressure. The main effector link of the renin-angiotensin system is angiotensin II, which causes vasospasm, activates heart contraction, inhibits the production of bradykinin, promotes proliferation, and fibrosis of blood vessels and myocardium, and promotes the synthesis of aldosterone in the glomerular zone of the adrenal cortex.Angiotensin-converting enzyme inhibitors are the mainstay of the treatment of arterial hypertension. They contribute to the correction of hypertension, hypertrophy, remodeling of the left ventricle, endothelial dysfunction, proliferation of arterial smooth muscles, and thrombotic phenomena. The 2018 ESH/ESC guidelines state that the first-line therapy in most patients with hypertension should be a fixed combination of a renin-angiotensin system blocker and a calcium channel blocker or diuretic. Blockade of the renin-angiotensin-aldosterone system is currently considered a gold standard of antihypertensive therapy.The objective is to systematize modern literature data on the role of ACE inhibitors in the treatment of arterial hypertension. Conclusion. To date, the concept of the role of the renin-angiotensin-aldosterone system (RAАS) in the pathogenesis of arterial hypertension and the role of ACE inhibitors in the treatment of hypertension has been formulated.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89567982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.14
I. Savka, S. Savka, M. Garas
Introduction. The image of any education institution is formed by its graduates. The prestige of the higher education institution (HEI) itself depends on the success of young people who have graduated from it, on how far they can exercise the academic rights granted by the educational documents of their institutions, and whether they can get appropriate jobs.During the 6-year stage of undergraduate education foreign students studying at medical HEI of Ukraine, along with their Ukrainian fellow students, must take a series of unified state qualification exams that prove the level of their theoretical (USQE 1) and practical (USQE 2) training.But no less important for foreigners are examinations for verification of diplomas obtained from the Ukrainian HEI on their returning to the home country, the successful passing of which gives them the right to apply for postgraduate study and to start their own medical practice in their countries.Aim of the research. The aim of our research was to study the effectiveness of such type of educational and methodological work at the university as the training of foreign citizens for taking exams needed for verification of diplomas in the graduates’ home country (Republic of India).Methods and material. The study includes 1046 graduates of the Medical Faculty No. 3 of the Bukovinian State Medical University, natives of India, who successfully completed their studies during the years 2012-2021 and obtained diplomas in "General Medicine", with the educational and qualification level of "Specialist" (starting from the graduation year 2022 the programme subject area 222 "Medicine", degree of higher education - "Master’s Degree"). The subject of the study was the 1st attempt results of the above mentioned cohort of graduates on their returning to the home country and taking the state exam for the verification of the diplomas. The obtained results were processed by standard methods of variation statistics.Results. Starting from the academic year 2012-2013, the training course for the verification of diplomas by graduates from India was successfully launched on the university's distance learning server, and from the academic year 2013-2014 the control mode of the course was implemented; its passing was considered successful when the student solved more than 50% of the test tasks from the total of 300 test questions. Currently, this training course has about 25,000 test tasks from the main fields of theoretical and practical medicine. According to the received and processed data, when in 2011 only 12% of the graduates passed the MCI screening test on the first attempt, in 2015 this rate increased to 53%, and in 2018 reached 64.1%. This is one of the best results for the verification of diplomas of foreign medical graduates in India after their return to their home country from different countries of the world. Conclusions. Student-centred training courses significantly increase the effectiveness of the educational process
{"title":"Training foreign citizens for taking exams needed for verification of diplomas in the graduates' home countries – as one of the types of educational and methodological work and a component of the educational process at BSMU","authors":"I. Savka, S. Savka, M. Garas","doi":"10.24061/2413-0737.xxvi.4.104.2022.14","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.14","url":null,"abstract":"Introduction. The image of any education institution is formed by its graduates. The prestige of the higher education institution (HEI) itself depends on the success of young people who have graduated from it, on how far they can exercise the academic rights granted by the educational documents of their institutions, and whether they can get appropriate jobs.During the 6-year stage of undergraduate education foreign students studying at medical HEI of Ukraine, along with their Ukrainian fellow students, must take a series of unified state qualification exams that prove the level of their theoretical (USQE 1) and practical (USQE 2) training.But no less important for foreigners are examinations for verification of diplomas obtained from the Ukrainian HEI on their returning to the home country, the successful passing of which gives them the right to apply for postgraduate study and to start their own medical practice in their countries.Aim of the research. The aim of our research was to study the effectiveness of such type of educational and methodological work at the university as the training of foreign citizens for taking exams needed for verification of diplomas in the graduates’ home country (Republic of India).Methods and material. The study includes 1046 graduates of the Medical Faculty No. 3 of the Bukovinian State Medical University, natives of India, who successfully completed their studies during the years 2012-2021 and obtained diplomas in \"General Medicine\", with the educational and qualification level of \"Specialist\" (starting from the graduation year 2022 the programme subject area 222 \"Medicine\", degree of higher education - \"Master’s Degree\"). The subject of the study was the 1st attempt results of the above mentioned cohort of graduates on their returning to the home country and taking the state exam for the verification of the diplomas. The obtained results were processed by standard methods of variation statistics.Results. Starting from the academic year 2012-2013, the training course for the verification of diplomas by graduates from India was successfully launched on the university's distance learning server, and from the academic year 2013-2014 the control mode of the course was implemented; its passing was considered successful when the student solved more than 50% of the test tasks from the total of 300 test questions. Currently, this training course has about 25,000 test tasks from the main fields of theoretical and practical medicine. According to the received and processed data, when in 2011 only 12% of the graduates passed the MCI screening test on the first attempt, in 2015 this rate increased to 53%, and in 2018 reached 64.1%. This is one of the best results for the verification of diplomas of foreign medical graduates in India after their return to their home country from different countries of the world. Conclusions. Student-centred training courses significantly increase the effectiveness of the educational process ","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73967964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.24061/2413-0737.xxvi.4.104.2022.16
Д.В. Проняєв, В.В. Кривецький, Т.В. Процак, Б.Ю. Банул, Н.Р. Ємєльяненко, В.Л. Волошин, D. Proniaiev, V. Kryvetskyi, T. Protsak, B. Banul, N. Yemelianenko, V. Voloshyn
The eighteenth century can rightly be considered the time of the most remarkable inventions in studying the lymphatic system. The Swiss Johann Conrad Peyer (1653–1712), in his "Exercitatio anatomico-medica de glandulis intestinorum earumque usu et affectionibus" (1677) described the presence of organized lymphatic vessels in the mucous membrane of the small intestine, which are named Peyer's plaques in his honor. Alexander Monro from the University of Edinburgh Medical School was the first to describe the function of the lymphatic system in detail. In 1701, Dutch botanist and anatomist Frederick Ruysch (1638-1731), a student of Van Horn, described the morphology and function of lymphatic valves. Another Dutch anatomist, Anton Nyuck (1650-1692), used the mercury injection technique to demonstrate the lymphatic system. The French anatomist Raymond Vuyssens (1641-1715), a pioneer in cardiac and nervous system anatomy, published his groundbreaking work in Nouvelles Découvertes sur le Coeur (1706) detailing the lymphatic system of the heart. The Italian histologist and microscopist Marcello Malpighi (1628–1689) gave a great impetus to the development of microanatomy with his pioneering microscope. New progress in the knowledge of the lymphatic system was provided by the English Hunter brothers. William Hunter (1718-1783) clearly suggested that lymphatic and milk vessels have two different properties that contribute to the formation of a single network of vessels endowed with an absorbing function. In 1731, Antonio Leprotti published a dissertation on the roots of the human lymphatic system. The Italian anatomist Paolo Mascagni (1755-1815) developed a special instrument with glass tubes for slowly introducing mercury into the lymphatic vessels. In the same year, 1787, Paolo Assalini published an essay on the lymphatic system, where the author tried to demonstrate the existence of "air-conducting" vessels. Like Nyuck and Mascagna, Vincenzo Foman (1794-1837) used mercury to inject the smallest lymphatic vessels. Another contribution to understanding the anatomy of the lymphatic system made the French anatomist Marie Philibert Constant Sappey (1810-1896), who was able to count the valves in the lymphatic vessels. The Polish pathologist Alfred Besiadecki (1839-1889) made a great contribution to the study of the lymphatic system of the skin. Thanks to his research, he refuted the prevailing hypothesis that the blood capillaries in the skin are located inside the lymphatic vessels. For the first time in history, he described the contiguous connection between lymphatic and blood vessels. In 1858, Carl Friedrich Wilhelm Ludwig (1816-1895) proposed the hypothesis that lymph is a filtrate of blood that is released from the capillary wall under the influence of intracapillary pressure. After that, the British doctor William Handley significantly contributed to the development of surgery for lymphatic disorders. In 1908, he introduced his technique of "lymphangiop
十八世纪完全可以被认为是研究淋巴系统的最杰出发明的时代。瑞士的约翰·康拉德·佩耶尔(1653-1712)在他的《肠粘膜的解剖-医学练习》(1677)中描述了小肠粘膜中有组织的淋巴管的存在，这些淋巴管被命名为佩耶尔斑块，以纪念他。爱丁堡大学医学院的亚历山大·门罗是第一个详细描述淋巴系统功能的人。1701年，荷兰植物学家和解剖学家弗雷德里克·鲁伊什(Frederick Ruysch, 1638-1731)，范霍恩的学生，描述了淋巴管的形态和功能。另一位荷兰解剖学家安东·纽克(Anton Nyuck, 1650-1692)使用水银注射技术来展示淋巴系统。法国解剖学家Raymond Vuyssens(1641-1715)是心脏和神经系统解剖学的先驱，他在《Nouvelles dsamouvertes sur le Coeur》(1706)中发表了他开创性的工作，详细介绍了心脏的淋巴系统。意大利组织学家和显微镜学家马尔皮吉(1628-1689)发明了显微镜，极大地推动了显微解剖学的发展。英国亨特兄弟在淋巴系统知识方面取得了新的进展。威廉·亨特(William Hunter, 1718-1783)明确提出淋巴管和乳管具有两种不同的特性，这两种特性有助于形成具有吸收功能的单一血管网络。1731年，安东尼奥·麻风蒂发表了一篇关于人类淋巴系统起源的论文。意大利解剖学家保罗·马斯卡尼(1755-1815)发明了一种特殊的仪器，用玻璃管慢慢地将汞引入淋巴管。同年，1787年，保罗·阿萨里尼发表了一篇关于淋巴系统的文章，作者试图证明“空气传导”血管的存在。和纽克和马斯cagna一样，Vincenzo Foman(1794-1837)使用水银注射最小的淋巴管。另一个对理解淋巴系统解剖学的贡献是法国解剖学家玛丽·菲利伯特·康斯坦斯·萨皮(Marie Philibert Constant Sappey, 1810-1896)，他能够计算淋巴管中的瓣膜。波兰病理学家Alfred Besiadecki(1839-1889)对皮肤淋巴系统的研究做出了巨大贡献。由于他的研究，他反驳了流行的假设，即皮肤中的毛细血管位于淋巴管内部。他在历史上第一次描述了淋巴管和血管之间的连续联系。1858年，卡尔·弗里德里希·威廉·路德维希(Carl Friedrich Wilhelm Ludwig, 1816-1895)提出假说，认为淋巴是在毛细血管内压力的影响下从毛细血管壁上释放出来的血液滤液。在那之后，英国医生威廉·汉德利(William Handley)为淋巴疾病手术的发展做出了重大贡献。1908年，他介绍了他的“淋巴管成形术”技术。这场淋巴革命和“复兴”的关键人物之一无疑是芬兰研究员Kari Kustaa Alitalo (1952-present)，他和他的团队以及与其他国际团队合作，在控制淋巴管发育和肿瘤淋巴转移的生长因子/受体系统方面做出了最重要的发现。
{"title":"History of the development of the lymphatic system (part two)","authors":"Д.В. Проняєв, В.В. Кривецький, Т.В. Процак, Б.Ю. Банул, Н.Р. Ємєльяненко, В.Л. Волошин, D. Proniaiev, V. Kryvetskyi, T. Protsak, B. Banul, N. Yemelianenko, V. Voloshyn","doi":"10.24061/2413-0737.xxvi.4.104.2022.16","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.4.104.2022.16","url":null,"abstract":"The eighteenth century can rightly be considered the time of the most remarkable inventions in studying the lymphatic system. The Swiss Johann Conrad Peyer (1653–1712), in his \"Exercitatio anatomico-medica de glandulis intestinorum earumque usu et affectionibus\" (1677) described the presence of organized lymphatic vessels in the mucous membrane of the small intestine, which are named Peyer's plaques in his honor. Alexander Monro from the University of Edinburgh Medical School was the first to describe the function of the lymphatic system in detail. In 1701, Dutch botanist and anatomist Frederick Ruysch (1638-1731), a student of Van Horn, described the morphology and function of lymphatic valves. Another Dutch anatomist, Anton Nyuck (1650-1692), used the mercury injection technique to demonstrate the lymphatic system. The French anatomist Raymond Vuyssens (1641-1715), a pioneer in cardiac and nervous system anatomy, published his groundbreaking work in Nouvelles Découvertes sur le Coeur (1706) detailing the lymphatic system of the heart. The Italian histologist and microscopist Marcello Malpighi (1628–1689) gave a great impetus to the development of microanatomy with his pioneering microscope. New progress in the knowledge of the lymphatic system was provided by the English Hunter brothers. William Hunter (1718-1783) clearly suggested that lymphatic and milk vessels have two different properties that contribute to the formation of a single network of vessels endowed with an absorbing function. In 1731, Antonio Leprotti published a dissertation on the roots of the human lymphatic system. The Italian anatomist Paolo Mascagni (1755-1815) developed a special instrument with glass tubes for slowly introducing mercury into the lymphatic vessels. In the same year, 1787, Paolo Assalini published an essay on the lymphatic system, where the author tried to demonstrate the existence of \"air-conducting\" vessels. Like Nyuck and Mascagna, Vincenzo Foman (1794-1837) used mercury to inject the smallest lymphatic vessels. Another contribution to understanding the anatomy of the lymphatic system made the French anatomist Marie Philibert Constant Sappey (1810-1896), who was able to count the valves in the lymphatic vessels. The Polish pathologist Alfred Besiadecki (1839-1889) made a great contribution to the study of the lymphatic system of the skin. Thanks to his research, he refuted the prevailing hypothesis that the blood capillaries in the skin are located inside the lymphatic vessels. For the first time in history, he described the contiguous connection between lymphatic and blood vessels. In 1858, Carl Friedrich Wilhelm Ludwig (1816-1895) proposed the hypothesis that lymph is a filtrate of blood that is released from the capillary wall under the influence of intracapillary pressure. After that, the British doctor William Handley significantly contributed to the development of surgery for lymphatic disorders. In 1908, he introduced his technique of \"lymphangiop","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80770294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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