Bukovinian Medical Herald最新文献

{"title":"The role of polymorphism of AGT genes (rs4762) and GNB3 (rs5443) in the development of essential hypertension","authors":"K. Voroniuk, L. Sydorchuk","doi":"10.24061/2413-0737.xxvi.3.103.2022.4","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.4","url":null,"abstract":"Assess the role of the polymorphism of AGT genes (rs4762) and GNB3 genes (rs5443) in the development of the essential arterial hypertension separately and by combining their polymorphic variants.Material and methods. The case-control study involved 100 patients with EAH stage II, 1-3 degrees of blood pressure (BP), high and very high cardiovascular risk. Among the patients, 21% (21) constituted men, and 79%(79) were women. The mean age of patients was 59.86±6.22 y.o. The control group comprised 60 almost healthy individuals, relevant in age (49.13±6.28y.o.) and gender distribution (63% - women, 37% - men). To study of polymorphism of AGT (rs4762) and GNB3 (rs5443) genes, we performed a qualitative polymerase chain reaction (PCR) in real time.Results. In patients with EAG residents of Northern Bukovyna mutated T-allele of AGT gene (rs4762) is found in 15,97% of cases, which is more frequent than in practically healthy by 9,72% (p=0,023); mutations of AGT gene in homozygous species in the control group have not met at all. Binary logistic regression confirmed an increase in the risk of inheriting EAH according to dominant and additive models in carriers of the minor T-allele of the AGT gene (rs4762) almost 3 times higher than in homozygotes for the major C-allele (р=0,04 і р=0,03). Inheritance of EAH is not associated with polymorphic variants of the GNB3 gene (rs5443). \u0000Conclusions. Тhe T-allele of the AGT gene (rs4762) increases the risk of development of EAH almost 3 times, while the polymorphic variants of the GNB3 gene (rs5443) are not the predictors of the emergence of EAH in the population.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"16 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78019319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibilities of differential diagnostics of livores mortis and bruises at different stages of the time since death using laser polarization methods","authors":"V. Voronov","doi":"10.24061/2413-0737.xxvi.3.103.2022.3","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.3","url":null,"abstract":"One of the urgent problems of forensic medicine remains the detection of hemorrhages in soft tissues during examinations of decayed corpses, because late cadaveric phenomena significantly distort the primary morphological picture, thereby complicating the examination. A change in the color of the skin after a few days or later after death most often makes the macroscopic diagnosis of hemorrhages impossible, in particular, their differentiation with livores mortis.The aim of work. To investigate the possibilities of detecting and differentiating bruises in areas of livores mortis at different stages of the time since death by the Muller matrix analysis of polarization images of optically anisotropic polycrystalline networks of human soft tissues. \u0000Material and methods. Skin sections with subcutaneous fatty tissue were collected from corpses of persons who died from mechanical injuries. The obtained samples were divided into two groups: intact samples of livores mortis at the stages of hypostasis and imbibition and with existing hemorrhages with a known time since death. Tissue research was carried out using a laser polarimeter of a standard scheme.Results. According to the results of the study, it was established that the values of the statistical moments of the 3rd and 4th orders (S3, S4) of the intensity distributions of laser images of the skin show a statistically significant (р1<0,001) difference between intact areas and when bruises and livores mortis are combined. The values of asymmetry and excess (S3 from 1,23±0,032 to 1,56±0,038; S4 from 1,49±0,024 to 1,94±0,021) for intact samples of livores mortis changed with increasing interval of time since death. Similar changes in S3 and S4 (S3 from 1,54±0,031 to 1,83±0,037; S3from 1,82±0,026 to 2,11±0,023) for skin samples in the areas of localization of livores mortis with existing bruises.Conclusions. Thus, it can be stated that the application of the Mueller matrix analysis method of polarization images of optically anisotropic polycrystalline networks of soft human tissues is effective in detecting and differentiating bruises in the areas of cadaveric spots at different stages of the postmortem interval by conducting a statistical analysis of the values of the statistical moments of 3rd and 4th order.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"147 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79958337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of time management on the efficiency of the teacher's work","authors":"O. Mykhaloiko, V. Gryb, M. Kupnovytska-Sabadosh, I. Mykhaloiko, I. Mykhaloiko","doi":"10.24061/2413-0737.xxvi.1.101.2022.12","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.1.101.2022.12","url":null,"abstract":"Objective. The problem of rational use of time in the teacher's work is quite relevant because the pace of life in modern realities is associated with overload, high demands, and a constant shortage of time, which negatively affects the productivity and quality of the work process.The aim: to analyze the literature on methods and laws of time management, which will help optimize the work of the teacher.Research methods: monitoring of scientific literature related to the rational distribution of time. \u0000Results. The principles of saving time are generalized, the importance of goal setting is specified; correctness of priority determination of tasks; emphasis is placed on detecting and eliminating \"time thieves\"; the importance of monitoring the implementation of the tasks has been proved.Conclusions. The main thing in the practical organization of the teacher's time is the sequence of planning stages, goal setting, decision making, implementation of plans, and control over their performance. Acquisition of time management skills leads to the formation of conscious self-control, concentration, determination, discipline, which increase efficiency.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83752178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure of cardiac pathology and some comorbidities, clinical, anamnestic, laboratory and functional characteristics of patients with СOVID-19 (own experience)","authors":"V. Shumakov, I. Malynovska, N. Tereshchenko, L. Babiy, O. Pogurelska, O. Voloshyna, Y. Kovalchuk, A. Abatiu, Y. Kuzmenko, L. Kisilevich, T. Simagina","doi":"10.24061/2413-0737.xxvi.1.101.2022.8","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.1.101.2022.8","url":null,"abstract":"Objective. Ɍo study clinical, anamnestic, laboratory and functional indices of patients (pts) with COVID-19 who hospitalized in the transformed unit on the basis of the department of myocardial infarction (MI) and cardiac rehabilitation (CR). Materials and methods. The study included 36 pts with COVID-19: the 1 st group (n = 19) consisted of pts ≤ 65 (57.8 ± 7.8) years, the 2nd group (n = 16) -> 65 (72.5 ± 7.0) years. 4 pts were transferred to the intensive care (2 of them died). Biochemical data, blood samples, indices of ECG, EchoCG, blood oxygen saturation were analyzed. 25 pts underwent computed tomography (ɋɌ). Ferritin, procalcitonin and troponin levels were determined according to indications. In addition to cardiac drugs, medications to treat COVID-19 were prescribed. All pts received pronoposition, oxygen support, exercise therapy, apparatus breathing exercises with resistance on inhalation and exhalation as CR. Results. Arterial hypertension (AH) was diagnosed in 15 (78.9%) pts in the 1st group and in 14 (87.5%) pts in the 2nd group, diabetes mellitus (DM) - in 3 (15.8%) and 5 ( 31.3%) pts, atrial fibrillation (AF) - in 10 (52.6%) and 14 (87.5%) (ɪ=0.03), heart failure (HF) above stage I - in 7 (36.8 %) and in 13 (81.2%) pts (ɪ=0.01), respectively. There was a slight increase in erythrocyte sedimentation rate, growth of stab leukocytes and platelets up to (277,8±102,3 and 182,0±55,8)·109/l (ɪ=0,002) in 1st and 2nd group with decrease of lymphocytes. The CRP level increased almost in two times (9.2 ± 6.1 mg / ml) in 1st group and up to (15,6±7,6 mg / ml) in 2nd group (ɪ=0.01) with values of D-dimer 0,29 ± 0.13 and 0,85±0,23 ng / ml (ɪ=0.09), respectively. At the CT scan lung lesions was 27% and 41% (ɪ=0.06), respectively, without clear relationship with blood oxygen saturation: SpO2 at admission was 92% in both groups with an increase of more than 95% at discharge in patients of 1st group and in the majority of patients in 2nd group (ɪ=0,07). The patients were treated in accordance to the current protocols. The stay in clinic was 11.4 and 15.4 days in 1st in 2nd group. Conclusions1. At admission 30.6% of patients were in a serious condition, while a prehospital diagnosis of COVID-19 was established in 57.7%. 2. In the structure of cardiac pathology and comorbidity, acute infection with SARS COV-2 occurred on the background of AH in 82.9% of patients, AF - in 25.7%, heart failure stage IIA - in 57.1%, diabetes - 22.9%. Except of AH, these conditions were significantly more frequent in the group of older patients and were accompanied with higher levels of CRP (3 times higher than normal) and D-dimer, as well as the area of lung lesions according to CT (41% compared to 27% in the first group) in the absence of a relationship with the index of blood oxygen saturation, which increased from ≤92.0% to 94.9% in the older group and up to 97.6% in the group of patients ≤ 65 years of age at discharged.3. COVID-19 therapy was carried out due to curr","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74010654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibilities of driver and passenger identification as a result of a comprehensive analysis of injuries inside the interior of a class J car in a head-on collision","authors":"V. Zozulia","doi":"10.24061/2413-0737.xxv.4.100.2021.5","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.5","url":null,"abstract":"Objective. To establish the possibility of identification of the driver and passenger as a result of a comprehensive analysis of injuries inside the interior of a class J car in a head-on collision.Materials and methods. 179 fatal traffic accidents were analyzed, of which the injuries of the driver and passenger in a frontal collision in the cabin of a class J car in accordance with the European Economic Classification were considered. Visual inspection and forensic examination were used. The detected damage was entered into the Microsoft Access database. Statistical analysis was performed in Microsoft Excel.Results. The analysis of the received damages by the driver and the passenger showed that in practice in salon of the modern car of a class J, specific signs of identification very seldom meet. Characteristic for the driver are ruptures of the lungs resulting from interaction with the steering column respectively, fractures of the ribs on the right and left, fractures of the sternum. The distribution of limb injuries was marked by a predominance of right-hand orientation - due to contact with the center console: soft tissue injuries of the right arm and right leg. Passengers are characterized by injuries of the left side - the result of interaction with the center console, respectively, were observed: head injury on the left, ruptures of the spleen, damage to soft tissues and bones on the left.Conclusions. Identification of the driver and passenger requires a comprehensive recording and analysis of the damage. Characteristic for the driver are ruptures of the lungs as a result of interaction with the steering column, respectively, fractures of the ribs on the right and left, fractures of the sternum. The distribution of driver limb injuries was marked by a predominance of right-hand orientation due to contact with the center console: soft tissue injuries of the right arm and right leg. Passengers are characterized by injuries of the left side - the result of interaction with the center console, respectively, were observed as follows: head injury on the left, ruptures of the spleen, damage to soft tissues and bones on the left.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82785927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of eosinophil-mediated inflammation in the formation of respiratory remodeling in patients with bronchial asthma of school age children","authors":"T. Dubetska, O. Koloskova, G. Bilyk","doi":"10.24061/2413-0737.xxv.4.100.2021.3","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.3","url":null,"abstract":"Objective. To investigate the features of inflammatory changes in the airways, taking into account remodeling markers, determined directly in the sputum of school age children with bronchial asthma, and to optimize the management of this disease.Material and methods. To study the features of the formation of airway remodeling 75 children with persistent bronchial asthma were comprehensively examined on the basis of the Regional Communal Non-Commercial Enterprise \"Chernivtsi Regional Children's Clinical Hospital\". The children were divided into 2 clinical groups depending on the level of vasoendothelial growth factor (VEGF) and matrix metalloproteinase 9 (MMP-9) in the sputum supernatant. The first (I) group included 37 schoolchildren whose VEGF concentration exceeded 80.0 ng / ml, and MMP-9 was more than 5.2 ng / ml. The second (II) comparison group was formed by 38 children in whom BA was not accompanied by accumulation of airway remodeling markers in the sputum supernatant above the indicated distribution point.Research results. The features of the formation of airway remodeling based on the accumulation of sputum markers such as VEGF> 80.0 ng / ml, MMP-9> 5.2 ng / ml were established. It was shown that bronchial remodeling is associated with a decrease in the group of patients with mild persistent asthma, loss of control over its symptoms, prevalence of family allergic history burdens according to both parental pedigrees and the negative effect of maternity smoking. The most sensitive marker in the verification of bronchial remodeling turned out to be a high marginal content of total IgE (> 750 IU / ml) in blood serum (test sensitivity - 95.8% (95% CI 89.7-98.8), which is advisable to combine in the diagnostic algorithm with more specific tests to optimize airway remodeling verification and develop personalized treatment strategies.Conclusion. The formation of bronchial remodeling in bronchial asthma in school age children is associated with the eosinophilic nature of bronchial inflammation, which is accompanied by an increase in the level of blood eosinophilia (> 10%) and sputum (on average 10.5 ± 1.0%) with an increase in myeloperoxidase activity and signs of degranulation of acidophilic granulocytes in sputum, as well as a high marginal concentration of total IgE (> 750 IU / ml) in blood serum in 95.8% of patients.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79564215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rrelationship between endothelial function, thickness of \"intima media\" with some clinical and metabolic parameters in hypertensive patients depending on genetic predictors","authors":"A. Sydorchuk","doi":"10.24061/2413-0737.xxv.4.100.2021.16","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.16","url":null,"abstract":"Objective. Тo study the relationship between endothelial function, \"intima-media\" thickness (IMT) of carotid arteries, some anthropometric, clinical and metabolic parameters in patients with essential arterial hypertension (EAH) depending on the genes polymorphism NOS3 (rs2070744) and GNB3 (rs5443).Material and methods. 100 patients with EAH and 48 practically healthy subjects (control group) participated in the study. All participants underwent clinical and laboratory examinations. The correlation values of Endothelium-Dependent Flow-Mediated Dilation of the Brachial Artery (FMD BA), total nitric oxide metabolites (NO), Soluble Vascular Cell Adhesion Molecule (sVCAM-1), the transcriptional activity of NOS3 gene, and carotid IMT were studied. GNB3 (rs5443) and NOS3 (rs2070744) genotyping were performed by Real-Time PCR. Results. In EAH patients with dominant T-allele carriers of the NOS3 gene (rs2070744) and/or C-allele of the GNB3 gene (rs5443) FMD BA inversely correlates with the triglycerides level (r =-0.45; p=0.042) and carotid IMT (r=-0.88-/-0.44/; P≤0.006-0.001). In the carriers of mutation C-allele of the NOS3 gene and TT-genotype of the GNB3 gene – with sVCAM-1 (r=-0.41; p=0.009), atherogenic index (r=-0.69; p=0.013) and diastolic arterial pressure (r=-0.84; p=0.036).Conclusion. Matrix correlations of endothelial function, IMT with clinical and metabolic parameters in EAH patients showed the dependence of connections on the allelic state of the genes NOS3 (rs2070744) and GNB3 (rs5443).","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82886512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variant anatomy of the muscles of the anterior compartment of the leg in human fetuses at 4-6 months","authors":"T. Komar","doi":"10.24061/2413-0737.xxv.4.100.2021.6","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.6","url":null,"abstract":"The objective is to find out the variant anatomy of the muscles of the anterior compartment of the leg in human fetuses at 4-6 months.Material and methods. The study was performed on 28 preparations of human fetuses of 81.0-230.0 mm parietal-coccygeal length (PCL) using macro-microscopic preparation, morphometry and statistical analysis.Results. The study of the structure and topography of the muscles of the anterior compartment of the leg in 26 human fetuses at 4-6 months revealed the classic sites of origin and attachment, the typical shape, and the number of muscles. Rare variants of the muscles of the anterior compartment of the leg have been found in two fetuses.Conclusions. The individual characteristics of the muscles of the anterior compartment of the lower leg in human fetuses are variations in their structure, shape, number, place of origin, and attachment. In most of the fetuses studied, the muscles of the anterior compartment of the lower leg had a classical origin, but the length and area of attachment varied with a tendency to lengthen and expand. The fetus of 105.0 mm PCL lateral and medial heads of the tibialis anterior muscle were detected, and an additional lower head of the long extensor muscle of the fingers was observed in the fetus of 175.0 mm PCL.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76051024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the daily profile of blood pressure and features of hemodynamics in patients with hypertension and osteoarthritis","authors":"D. Sobko, T. Ilashchuk, I. Okipniak","doi":"10.24061/2413-0737.xxv.4.100.2021.17","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.17","url":null,"abstract":"The objective is to assess the severity and features of arterial hypertension (AH) in patients who suffer from osteoarthritis (OA) using indicators of daily blood pressure monitoring (DBPM) and echocardiography (echoCG).Material and methods. According to the purpose and objectives of our dissertation research, a total of 130 people of different ages and genders with hypertension and OA were examined. Of these, group I included 60 patients with hypertension combined with OA. Group II consisted of 30 patients with hypertension without concomitant OA. Group III included 30 people with OA without concomitant hypertension. The control group consisted of 10 healthy people.Results. The results of the study show a burdened course of hypertension in the case of its combination with OA compared with patients with hypertension not combined with OA. The percentage of blood pressure in the subjects of group I is higher due to a slight decrease at night compared with patients of group II, in which there was a steady increase in blood pressure at night. Interventricular septal thickness rates in group I are 8% (p < 0,05) higher than in group II. Indicators of LА size in patients with combined pathology (group II) by 12,5% (p < 0,05) are higher than similar in patients with hypertension without concomitant OA (group I). The LV wall is moderately thickened in the subjects of group I, which is 9% (p < 0,05) higher than the same indicator in patients of group II, in whom the LV wall is slightly thickened. In the subjects of group III indicators corresponded to the norm or the upper limit of the norm. In addition, in patients of group I there is in inverse correlation (r = -0.31, p < 0.05) between the mean daily average daily blood pressure and ghrelin. An inverse correlation was also found between serum melatonin concentrations and average DBP data (r = -0.49, p < 0.05).Conclusions. The results of DBPM and echocardiography in patients with hypertension combined with OA indicate a mutually burdened course of these diseases, which increases the risk of complications from the cardiovascular system. Therefore, these non-invasive research methods can be used for early diagnosis of hypertension progression and selection of appropriate drug correction.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81482139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of an applied use of stem cells","authors":"D. Proniaiev, V. Voloshyn, V. Melnyk, N. Yemelianenko, M. Kavun, M. Perepeliuk, K. Yakovets","doi":"10.24061/2413-0737.xxv.4.100.2021.21","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.21","url":null,"abstract":"The literary review deals with analyzing the information found in the scientific literature concerning the practical use of stem cells for the treatment of different diseases. The most essential and promising source of stem cells is umbilical blood. Practical use of stem cells is of particular difficulty. An important effect of stem cells that must be kept in mind is a specific aberration of their properties in the experiments carried out \"in vivo\" and \"in vitro\". Induced pluripotential stem cells have become mainly spread to be introduced into practice. It is associated with the fact that, as a rule, this type of cells is genetically compatible with a certain organism. This literary review presents both the major historical landmarks in the development of science concerning the applied use of stem cells and the latest data of the scientific literature. Joseph Altman’s discovery of adult neurogenesis, who confirmed the existence of stem cells of the brain, has become sensational. One of the most investigated issues is the process of differentiation of the human pluripotential stem cells into neurons and astrocytes. This differentiation was first described in 2001. In this respect, the liver is of special interest to cellular biologists who deal with stem cells. Two types of cells in the liver of an adult claim to be stem cells: hepatocytes under extreme conditions (partial hepatectomy) acquire properties of unipotential stem cells able to form only one type of differential cells of a lower level; poorly differentiated oval cells possessing biopotential properties, that is, able to form both hepatocytes and cholangiocytes. In dentistry and oral surgery, transplantation of mesenchymal stem cells can be used for the restoration of bone tissue or regeneration of the dental tissue. During transplantation, stem cells isolated from the bone marrow can provide restoration of the damaged osseous tissue of the face, and cells isolated from the tooth pulp restore dentin. Our review of scientific literature concerning the questions of investigation of stem cells is indicative of considerable interest of scientists in this issue. It should be noted that foreign scientific literature on the issue prevails considerably. It is reasonable to indicate that amount of scientific research carried out by our domestic scientists is not adequate. Thus, considering the above, the subject of our study is rather relevant.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72739918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}