Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.16
V. Prysyazhnyuk, B. Senyuk, O. Glubochenko, P. Prysyazhnyuk, O. Bukach
Scientific review covers current data regarding the role of quercetin in the therapeutic corrections of various liver diseases, in particular non-alcoholic fatty liver disease, chronic hepatitis, drug-induced liver disease. The aim of the review was to sum up current scientific data regarding quercetin properties, its mechanism of action and possibilities of this flavonoid in the treatment of various liver diseases.Conclusions. Quercetin is found to possess antioxidant, anti-inflammatory, hypolipidemic, antisteatotic and antifibrotic properties. The abovementioned makes this flavonoid potentially useful in the treatment of various liver disease, in particular non-alcoholic fatty liver disease, chronic hepatitis of different etiologies, and drug induced liver disease.
{"title":"The role of quercetin in the treatment of liver diseases: the review based on experimental and clinical investigations","authors":"V. Prysyazhnyuk, B. Senyuk, O. Glubochenko, P. Prysyazhnyuk, O. Bukach","doi":"10.24061/2413-0737.xxvi.3.103.2022.16","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.16","url":null,"abstract":"Scientific review covers current data regarding the role of quercetin in the therapeutic corrections of various liver diseases, in particular non-alcoholic fatty liver disease, chronic hepatitis, drug-induced liver disease. The aim of the review was to sum up current scientific data regarding quercetin properties, its mechanism of action and possibilities of this flavonoid in the treatment of various liver diseases.Conclusions. Quercetin is found to possess antioxidant, anti-inflammatory, hypolipidemic, antisteatotic and antifibrotic properties. The abovementioned makes this flavonoid potentially useful in the treatment of various liver disease, in particular non-alcoholic fatty liver disease, chronic hepatitis of different etiologies, and drug induced liver disease.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73422624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.9
O. Lytvynenko, O. Vanchulyak
Purpose of work. Development of a technique for determining the time of formation of damage to human internal organs by digital histological methods of polarization reconstruction of circular birefringence of molecular complexes.Materials and methods. The object of the study was the histology of samples of human internal organs (brain, kidney and liver) with different duration of damage from 1 to 120 hours. For control, we used biological tissue samples of those who died from coronary heart disease with different duration of damage from 1 to 120 hours. The studies were carried out using the technique of polarization reconstruction of circular birefringence of molecular complexes.Results. A set of diagnostically relevant relationships between temporal changes in the statistical structure of topographic maps of circular birefringence of optically active molecular complexes of histological sections of human internal organs with different duration of damage and variations in the mean value, dispersion, asymmetry and excess, characterizing the distribution of the value of this parameter of anisotropy, has been determined.Conclusions. A new original method has been developed for tomography of the optical activity of molecular complexes of tissues of human internal organs in a digital histological study of the age of damage to the tissues of the brain, liver and kidney, as well as the myocardium and lung tissue at a time interval of 1 up to 120 hours.
{"title":"Forensic determination of the time of formation of damage to internal human organs using the method of reconstructing the optical activity of histological sections","authors":"O. Lytvynenko, O. Vanchulyak","doi":"10.24061/2413-0737.xxvi.3.103.2022.9","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.9","url":null,"abstract":"Purpose of work. Development of a technique for determining the time of formation of damage to human internal organs by digital histological methods of polarization reconstruction of circular birefringence of molecular complexes.Materials and methods. The object of the study was the histology of samples of human internal organs (brain, kidney and liver) with different duration of damage from 1 to 120 hours. For control, we used biological tissue samples of those who died from coronary heart disease with different duration of damage from 1 to 120 hours. The studies were carried out using the technique of polarization reconstruction of circular birefringence of molecular complexes.Results. A set of diagnostically relevant relationships between temporal changes in the statistical structure of topographic maps of circular birefringence of optically active molecular complexes of histological sections of human internal organs with different duration of damage and variations in the mean value, dispersion, asymmetry and excess, characterizing the distribution of the value of this parameter of anisotropy, has been determined.Conclusions. A new original method has been developed for tomography of the optical activity of molecular complexes of tissues of human internal organs in a digital histological study of the age of damage to the tissues of the brain, liver and kidney, as well as the myocardium and lung tissue at a time interval of 1 up to 120 hours.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78112873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.2
O. Adamovych, M. Vasyliv, Z. Z. Masna
The relevance of the problem of early diagnosis of pathological changes in the mammary glands (MG) of women of different ages is due to the fact that in the world rankings of neoplasms localization, both benign and malignant, the MG occupies a leading position today. According to multiple information sources, more than 80% of women of reproductive age are diagnosed with various MG diseases. For the purpose of early detection of pathological changes developing in MG today, mammography is widely used, which allows easy visualization of calcifications, MG and obtaining their complete characteristics.The purpose of our study was to determine the frequency of detection and to study the age-related dynamics of different types of calcifications in the mammary glands of mature and elderly women according to the mammography results.Material and methods. In the course of the research, a randomized sample of archival anonymized mammograms of 100 women (50 mature and 50 elderly) who underwent screening or preventive examination was processed. Examinations were performed on the Fujifilm Amulet Innovality device (Japan) in direct (SS) and medial-lateral oblique (MLO) projections. Calcifications were assessed by shape, number, and size.Research results. It was determined that in a randomized sample of examined women, only 34% of adults and 28% of elderly people did not have calcifications in the mammary glands. In 24% of adults and 48% of elderly people, calcifications were detected in the mammary glands bilaterally, in another 42% of adults and 24% of elderly people - in only one of the the mammary glands. Among women of mature age, the largest specific share in the examined sample belongs to persons without calcifications in the mammary glands; among the elderly, the largest share is women with calcifications in both mammary glands. According to the results of the conducted research in a randomized sample of mature and elderly women, the following was found: isolated scattered punctate calcifications (35% of the examined); single punctate/round calcifications (23% of the examined); annular calcifications (11% of the examined); multiple calcifications (19% of the examined); calcifications larger than 1 mm (14% of the examined); calcified vessels (4% of the examined).Conclusions. Digital mammography is a highly informative method of examining the mammary glands, which allows us to visualize calcifications and differentiate them by size, shape and number. According to the results of the analysis of a randomized examination sample of 100 mature and elderly women, various variants of calcifications were found as single, diffuse, punctate; single punctate/round; annular; multiple; greater than 1 mm; as well as calcified vessels. With age, the frequency of mammary gland calcifications increases.
{"title":"Analysis of the manifestation frequency of different variants of calcifications in the mammary glands in women of mature and old age according to screening mammography data","authors":"O. Adamovych, M. Vasyliv, Z. Z. Masna","doi":"10.24061/2413-0737.xxvi.3.103.2022.2","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.2","url":null,"abstract":"The relevance of the problem of early diagnosis of pathological changes in the mammary glands (MG) of women of different ages is due to the fact that in the world rankings of neoplasms localization, both benign and malignant, the MG occupies a leading position today. According to multiple information sources, more than 80% of women of reproductive age are diagnosed with various MG diseases. For the purpose of early detection of pathological changes developing in MG today, mammography is widely used, which allows easy visualization of calcifications, MG and obtaining their complete characteristics.The purpose of our study was to determine the frequency of detection and to study the age-related dynamics of different types of calcifications in the mammary glands of mature and elderly women according to the mammography results.Material and methods. In the course of the research, a randomized sample of archival anonymized mammograms of 100 women (50 mature and 50 elderly) who underwent screening or preventive examination was processed. Examinations were performed on the Fujifilm Amulet Innovality device (Japan) in direct (SS) and medial-lateral oblique (MLO) projections. Calcifications were assessed by shape, number, and size.Research results. It was determined that in a randomized sample of examined women, only 34% of adults and 28% of elderly people did not have calcifications in the mammary glands. In 24% of adults and 48% of elderly people, calcifications were detected in the mammary glands bilaterally, in another 42% of adults and 24% of elderly people - in only one of the the mammary glands. Among women of mature age, the largest specific share in the examined sample belongs to persons without calcifications in the mammary glands; among the elderly, the largest share is women with calcifications in both mammary glands. According to the results of the conducted research in a randomized sample of mature and elderly women, the following was found: isolated scattered punctate calcifications (35% of the examined); single punctate/round calcifications (23% of the examined); annular calcifications (11% of the examined); multiple calcifications (19% of the examined); calcifications larger than 1 mm (14% of the examined); calcified vessels (4% of the examined).Conclusions. Digital mammography is a highly informative method of examining the mammary glands, which allows us to visualize calcifications and differentiate them by size, shape and number. According to the results of the analysis of a randomized examination sample of 100 mature and elderly women, various variants of calcifications were found as single, diffuse, punctate; single punctate/round; annular; multiple; greater than 1 mm; as well as calcified vessels. With age, the frequency of mammary gland calcifications increases.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"33 7-8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77665758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.7
N. Kobryn, V. Hereliuk
Objective – to determine the effectiveness of root canal treatment while using different groups of sealers based on a long-term result of radiological examination.Materials and methods. An analysis of the data of various types of X-ray examination (computed tomography, digital orthopantomography, and focused digital X-ray) of teeth where root canal treatment had been done using sealers based on zinc-oxide-eugenol or resorcinol-formalin (active sealers), or sealers based on epoxy resins (passive sealers) was performed. The radiological picture of 579 teeth, and 1120 roots, in particular, was evaluated based on radiological images of patients aged 18 to 68 years. Computer programs based on Microsoft Excel 2019 were used for the statistical processing of the research material.The results. Changes in periapical tissues were observed significantly less often when using sealers based on epoxy resins, on average at 27.42%. X-ray changes were absent for 21.92% more often when active sealers were used, which is probably due to a higher frequency of their use in the examined group of patients. It was found that in (62.67±3.95)% of cases, periapical changes were present when the level of obturation was more than 3 mm to the apex of the root and with the use of active sealers, while when using passive, periapical changes occurred significantly more often - in (82.43±4.42)%. It was determined that with preserved sealing of the orifice part, periapical changes were noticed in (55.71±3.43)% when using active sealers, while with broken sealing, these changes occurred more often - in (69.16±2.63)%. However, when using passive sealers and coronal leakage, periapical changes were only (30.84±2.63)%, which may indicate the high sealing properties of sealers based on epoxy resins.Conclusions. Periapical changes occurred significantly less often in the root canals of patients whose filling was performed with epoxy-based sealers, the absence of periapical changes was determined 27.42% more often than when using active sealers. At the obturation level of 3 mm and >3 mm to the apex of the root canal, filling with active sealers gave better efficiency due to a significantly lower number of complications in the form of periapical changes. Periapical changes occur much more often when there is coronal leakage, mainly when active sealers are used and constitute (69.16±2.63)% of cases.
{"title":"The effectiveness of root canal treatment depending on used sealer","authors":"N. Kobryn, V. Hereliuk","doi":"10.24061/2413-0737.xxvi.3.103.2022.7","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.7","url":null,"abstract":"Objective – to determine the effectiveness of root canal treatment while using different groups of sealers based on a long-term result of radiological examination.Materials and methods. An analysis of the data of various types of X-ray examination (computed tomography, digital orthopantomography, and focused digital X-ray) of teeth where root canal treatment had been done using sealers based on zinc-oxide-eugenol or resorcinol-formalin (active sealers), or sealers based on epoxy resins (passive sealers) was performed. The radiological picture of 579 teeth, and 1120 roots, in particular, was evaluated based on radiological images of patients aged 18 to 68 years. Computer programs based on Microsoft Excel 2019 were used for the statistical processing of the research material.The results. Changes in periapical tissues were observed significantly less often when using sealers based on epoxy resins, on average at 27.42%. X-ray changes were absent for 21.92% more often when active sealers were used, which is probably due to a higher frequency of their use in the examined group of patients. It was found that in (62.67±3.95)% of cases, periapical changes were present when the level of obturation was more than 3 mm to the apex of the root and with the use of active sealers, while when using passive, periapical changes occurred significantly more often - in (82.43±4.42)%. It was determined that with preserved sealing of the orifice part, periapical changes were noticed in (55.71±3.43)% when using active sealers, while with broken sealing, these changes occurred more often - in (69.16±2.63)%. However, when using passive sealers and coronal leakage, periapical changes were only (30.84±2.63)%, which may indicate the high sealing properties of sealers based on epoxy resins.Conclusions. Periapical changes occurred significantly less often in the root canals of patients whose filling was performed with epoxy-based sealers, the absence of periapical changes was determined 27.42% more often than when using active sealers. At the obturation level of 3 mm and >3 mm to the apex of the root canal, filling with active sealers gave better efficiency due to a significantly lower number of complications in the form of periapical changes. Periapical changes occur much more often when there is coronal leakage, mainly when active sealers are used and constitute (69.16±2.63)% of cases.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91518063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.6
O. Huivaniuk, H. Stupnytska
The Aim. The current study evaluates the possibility of using the C646G polymorphic variant of the NR3C1 gene (rs41423247) for the personalized administration of combination therapy with inhaled glucocorticosteroids (iGCs) and long-acting β2-agonists in patients with asthma/COPD overlap (ACO) with and without obesity.Material and methods. Forty patients with ACO were included (17 patients with BMI < 30 and 23 with obesity (BMI ≥ 30) to received combined treatment with the use of prolonged β 2 -agonists and ICS. The CAT test, the asthma control questionnaire (Asthma Control Questionnaire-5 - ACQ-5) and the BODE index were used to analyze treatment outcomes, with genetic markers being considered one month after the study began. To assess the distribution of genotypes and alleles between groups, we used the two-tailed Pearson chi-square test (χ2) and the odds ratio (OR) in the 95% confidence interval (CI). Mathematical processing of the obtained data was performed using the SPSS (Statistical Package for Social Science Statistics) 16,0 programs.Results. The analysis of the obtained results revealed that a significant frequency of the GG genotype (80,00%) was observed in the group of patients who noted progressive deterioration of the symptom according to the CAT test, which significantly differed [χ²=17,293; p˂0,001] from that in the group of patients with positive CAT dynamics, in whom the GG genotype did not occur at all. In patients with no improvement on the CAT scale, the rate of the G allele was 0,96, and the rate of the C allele was 0,44; in patients with positive dynamics on the CAT scale, these numbers were 0,4 and 1, respectively [χ²=7,721; p=0,006; BP=5,000; 95% CI: 1,547-16,163]. The results of analyzing the dynamics of the number of points obtained for the ACQ-5 were comparable to those obtained when the CAT test was evaluated. The GG genotype was found in 50,00% of patients with negative or complete absence dynamics of the BODE index, compared with 12,5% of patients with positive dynamics [χ2=5,943, р=0,015; ВР=7,000 (95 % ДІ: 1,300-37,705)]. In the group of ACO patients with obesity, 94,44% of patients with negative or absent BODE index dynamics were carriers of the G allele [χ2=8,074, р=0,005], whereas in the group of ACO patients with normal/overweight body weight, all patients with the GG genotype had negative BODE index dynamics [χ2=6,679; р=0,016]. The GG genotype was found in 59,1% of patients with negative and absent dynamics of the BODE index, but not in any patient with positive dynamics of the BODE index [χ2=12,472, р˂0,001; ВР=24,556 (95 % ДІ: 2,752-219,100)]. Among the ACO patients studied, we identified 14 people with the GG genotype for the NR3C1 gene (rs41423247), 13 of whom (92,85%) had zero or negative dynamics of the condition in combined therapy with ICS and long-acting 2 agonists, according to the BODE index estimate. When the changes in the BODE index in non-obese patients (BMI˂30) were studied when the long-acting
{"title":"Evaluation of treatment effectiveness of asthma/COPD overlap in patients with and without obesity considering the polymorphic variant C646G of the NR3C1 gene (rs41423247)","authors":"O. Huivaniuk, H. Stupnytska","doi":"10.24061/2413-0737.xxvi.3.103.2022.6","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.6","url":null,"abstract":"The Aim. The current study evaluates the possibility of using the C646G polymorphic variant of the NR3C1 gene (rs41423247) for the personalized administration of combination therapy with inhaled glucocorticosteroids (iGCs) and long-acting β2-agonists in patients with asthma/COPD overlap (ACO) with and without obesity.Material and methods. Forty patients with ACO were included (17 patients with BMI < 30 and 23 with obesity (BMI ≥ 30) to received combined treatment with the use of prolonged β 2 -agonists and ICS. The CAT test, the asthma control questionnaire (Asthma Control Questionnaire-5 - ACQ-5) and the BODE index were used to analyze treatment outcomes, with genetic markers being considered one month after the study began. To assess the distribution of genotypes and alleles between groups, we used the two-tailed Pearson chi-square test (χ2) and the odds ratio (OR) in the 95% confidence interval (CI). Mathematical processing of the obtained data was performed using the SPSS (Statistical Package for Social Science Statistics) 16,0 programs.Results. The analysis of the obtained results revealed that a significant frequency of the GG genotype (80,00%) was observed in the group of patients who noted progressive deterioration of the symptom according to the CAT test, which significantly differed [χ²=17,293; p˂0,001] from that in the group of patients with positive CAT dynamics, in whom the GG genotype did not occur at all. In patients with no improvement on the CAT scale, the rate of the G allele was 0,96, and the rate of the C allele was 0,44; in patients with positive dynamics on the CAT scale, these numbers were 0,4 and 1, respectively [χ²=7,721; p=0,006; BP=5,000; 95% CI: 1,547-16,163]. The results of analyzing the dynamics of the number of points obtained for the ACQ-5 were comparable to those obtained when the CAT test was evaluated. The GG genotype was found in 50,00% of patients with negative or complete absence dynamics of the BODE index, compared with 12,5% of patients with positive dynamics [χ2=5,943, р=0,015; ВР=7,000 (95 % ДІ: 1,300-37,705)]. In the group of ACO patients with obesity, 94,44% of patients with negative or absent BODE index dynamics were carriers of the G allele [χ2=8,074, р=0,005], whereas in the group of ACO patients with normal/overweight body weight, all patients with the GG genotype had negative BODE index dynamics [χ2=6,679; р=0,016]. The GG genotype was found in 59,1% of patients with negative and absent dynamics of the BODE index, but not in any patient with positive dynamics of the BODE index [χ2=12,472, р˂0,001; ВР=24,556 (95 % ДІ: 2,752-219,100)]. Among the ACO patients studied, we identified 14 people with the GG genotype for the NR3C1 gene (rs41423247), 13 of whom (92,85%) had zero or negative dynamics of the condition in combined therapy with ICS and long-acting 2 agonists, according to the BODE index estimate. When the changes in the BODE index in non-obese patients (BMI˂30) were studied when the long-acting","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89342256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.8
V.Y. Kryvonosov, S. Pavlov, O. Dudko, D. Yakymyuk, O. G. Shaiko-Shaikovsky
During the rehabilitation of the patient, accidental and shock loads are the main cause of aseptic loosening and damage to the elements of the fixing structure (FC). The lack of control over the formation of cartilaginous callus in the fracture zone causes an increase in the period of incapacity for work and an increase in material costs associated with the patient's stay in the hospital.The partial load on the bone is simulated, which is 25% of the calculated value and is equal to the average body weight of the patient. On the basis of the obtained data, a new method and device were developed for non-invasive detection of the initial moment of weakening or fracture of the fixing structure, detection of improper fracture fusion, diagnosis of the formation and control of cartilage callus growth, detection of the appearance of the initial moment of the inflammatory process in the patient's body and diagnosis of the causes of this process. The requirements for a possible method of non-invasive diagnosis of the condition of a tubular bone fracture are formulated. Criterion dependencies of the controlled parameters were established. The effect of random loads, which are the cause of failures of the fixing structure, has been proven. Wireless transmission of electricity and information made it possible to develop a method of non-invasive control and diagnosis of fracture of tubular bones and to establish criterion dependencies between controlled parameters. For a comprehensive diagnosis of the patient's recovery, it is sufficient to monitor the pressure at three points, the bending moment at the site of the bone fracture, the temperature of the periosteum and the temperature of any other point of the body.
{"title":"Radioelectronic wireless systems for non-invasive diagnostics of tubular bone fractures during body osteosynthesis","authors":"V.Y. Kryvonosov, S. Pavlov, O. Dudko, D. Yakymyuk, O. G. Shaiko-Shaikovsky","doi":"10.24061/2413-0737.xxvi.3.103.2022.8","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.8","url":null,"abstract":"During the rehabilitation of the patient, accidental and shock loads are the main cause of aseptic loosening and damage to the elements of the fixing structure (FC). The lack of control over the formation of cartilaginous callus in the fracture zone causes an increase in the period of incapacity for work and an increase in material costs associated with the patient's stay in the hospital.The partial load on the bone is simulated, which is 25% of the calculated value and is equal to the average body weight of the patient. On the basis of the obtained data, a new method and device were developed for non-invasive detection of the initial moment of weakening or fracture of the fixing structure, detection of improper fracture fusion, diagnosis of the formation and control of cartilage callus growth, detection of the appearance of the initial moment of the inflammatory process in the patient's body and diagnosis of the causes of this process. The requirements for a possible method of non-invasive diagnosis of the condition of a tubular bone fracture are formulated. Criterion dependencies of the controlled parameters were established. The effect of random loads, which are the cause of failures of the fixing structure, has been proven. Wireless transmission of electricity and information made it possible to develop a method of non-invasive control and diagnosis of fracture of tubular bones and to establish criterion dependencies between controlled parameters. For a comprehensive diagnosis of the patient's recovery, it is sufficient to monitor the pressure at three points, the bending moment at the site of the bone fracture, the temperature of the periosteum and the temperature of any other point of the body.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74565988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.1
V. Abdullaiev, A. Hryhorenko
The paper examines the treatment results of women with non-atypical hyperplastic endometrial processes with the use of anti-inflammatory drugs for a long time. The purpose of our study was to evaluate the effectiveness of the proposed treatment regimen depending on the type of hyperplastic processes and their connection with chronic inflammatory processes in the endometrium. Material and methods. We examined 101 women, of which 29 women with hyperplastic processes without accompanying chronic endometritis were included in experimental group №1, 49 women with a combination of hyperplastic processes and chronic endometritis were included in experimental group №2, the control group included 23 women with hyperplastic processes without chronic endometritis. The control group received only hormonal therapy, the experimental group №1 received long-term anti-inflammatory nonsteroidal drugs in addition to hormonal correction, the experimental group №2 received a course of broad-spectrum antibiotics in addition to anti-inflammatory drugs. Treatment effectiveness was evaluated 6, 12 and 24 months after hysteroscopy.Results of the study. 24 months after hysteroscopy in the control group, we observed 43.5% recurrence of hyperplastic endometrial processes, while at the same time when using anti-inflammatory therapy with non-steroidal drugs (experimental group No. 1), after 24 months we observed 20.7% recurrence ( p<0.05) and in women with a combination of GE and HE (experimental group No. 2) with the use of anti-inflammatory nonsteroidal drugs and antibiotics, the relapse rate was 22.4% (p<0.05). The results of additional studies and the use of statistical methods have proven that the effectiveness of treatment is related to the applied methods and is not accidental.Conclusions. The use of non-steroidal anti-inflammatory drugs increases the effectiveness of anti-recurrence conservative treatment of women with hyperplastic processes after hysteroscopy.
{"title":"Results of treatment of endometrial hyperplasia with the use of non-steroidal anti-inflammatory agents against the background of chronic endometritis and without accompanying inflammatory process","authors":"V. Abdullaiev, A. Hryhorenko","doi":"10.24061/2413-0737.xxvi.3.103.2022.1","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.1","url":null,"abstract":"The paper examines the treatment results of women with non-atypical hyperplastic endometrial processes with the use of anti-inflammatory drugs for a long time. The purpose of our study was to evaluate the effectiveness of the proposed treatment regimen depending on the type of hyperplastic processes and their connection with chronic inflammatory processes in the endometrium. Material and methods. We examined 101 women, of which 29 women with hyperplastic processes without accompanying chronic endometritis were included in experimental group №1, 49 women with a combination of hyperplastic processes and chronic endometritis were included in experimental group №2, the control group included 23 women with hyperplastic processes without chronic endometritis. The control group received only hormonal therapy, the experimental group №1 received long-term anti-inflammatory nonsteroidal drugs in addition to hormonal correction, the experimental group №2 received a course of broad-spectrum antibiotics in addition to anti-inflammatory drugs. Treatment effectiveness was evaluated 6, 12 and 24 months after hysteroscopy.Results of the study. 24 months after hysteroscopy in the control group, we observed 43.5% recurrence of hyperplastic endometrial processes, while at the same time when using anti-inflammatory therapy with non-steroidal drugs (experimental group No. 1), after 24 months we observed 20.7% recurrence ( p<0.05) and in women with a combination of GE and HE (experimental group No. 2) with the use of anti-inflammatory nonsteroidal drugs and antibiotics, the relapse rate was 22.4% (p<0.05). The results of additional studies and the use of statistical methods have proven that the effectiveness of treatment is related to the applied methods and is not accidental.Conclusions. The use of non-steroidal anti-inflammatory drugs increases the effectiveness of anti-recurrence conservative treatment of women with hyperplastic processes after hysteroscopy.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87319625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.5
M. Gubin, V. Sokol, P. Leontiev, P. A. Kaplunovskyi
The Aim. the forensic determination of the severity of closed chest injuries with intact ribs in victims hospitalized in a specialized surgical hospital to establish diagnostic expert criteria for expert assessment of such dmages.Materials and methods. 52 case histories of patients hospitalized hospitalized at the Kharkiv institute of general and emergency surgery named after V.T. Zaitseva were analyzed. Patients were divided into 4 groups based on the dynamics of morpho-functional pathological changes of the injured organs, the final results of the injury, and the presence of life-threatening phenomena.Results. The analysis of observations showed that the main traumatic factor in the emergence of the studied cases is the impact mechanism of blunt solid objects on the chest. Patients with closed blunt chest trauma were divided into observation groups depending on the morphology of the injuries received. The following main variants of the received injury are distinguished: without a contusion and bruised chest and the presence of intrapleural injuries and complications, a chest contusion without complications. Severe injuries were estimated in 15.4% of cases of acute respiratory failure and cases of trauma of partial or complete lung loss. Injuries of medium severity were established in 26.9% of cases of trauma in the absence of danger to life. Minor injuries were established in 57.7% of cases of trauma in the presence of intrapleural injuries and complications or minor injuries without any complications.Conclusions. When forensically determining the degree of severity of closed injuries of the chest, it is necessary to evaluate the morphology of the injury and clinic functional manifestations of life-threatening phenomena. At the same time, diagnostic signs which must be used when determining the severity of physical injuries are the following: the presence of clinical and functional signs of acute respiratory failure, loss of part or all of the respiratory organ (lungs), dynamics and duration of recovery of post-traumatic morpho-functional changes injured organs.
{"title":"Сlosed chest injury with preservation of the integrity of the ribs in the forensic medical assessment of its severity","authors":"M. Gubin, V. Sokol, P. Leontiev, P. A. Kaplunovskyi","doi":"10.24061/2413-0737.xxvi.3.103.2022.5","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.5","url":null,"abstract":"The Aim. the forensic determination of the severity of closed chest injuries with intact ribs in victims hospitalized in a specialized surgical hospital to establish diagnostic expert criteria for expert assessment of such dmages.Materials and methods. 52 case histories of patients hospitalized hospitalized at the Kharkiv institute of general and emergency surgery named after V.T. Zaitseva were analyzed. Patients were divided into 4 groups based on the dynamics of morpho-functional pathological changes of the injured organs, the final results of the injury, and the presence of life-threatening phenomena.Results. The analysis of observations showed that the main traumatic factor in the emergence of the studied cases is the impact mechanism of blunt solid objects on the chest. Patients with closed blunt chest trauma were divided into observation groups depending on the morphology of the injuries received. The following main variants of the received injury are distinguished: without a contusion and bruised chest and the presence of intrapleural injuries and complications, a chest contusion without complications. Severe injuries were estimated in 15.4% of cases of acute respiratory failure and cases of trauma of partial or complete lung loss. Injuries of medium severity were established in 26.9% of cases of trauma in the absence of danger to life. Minor injuries were established in 57.7% of cases of trauma in the presence of intrapleural injuries and complications or minor injuries without any complications.Conclusions. When forensically determining the degree of severity of closed injuries of the chest, it is necessary to evaluate the morphology of the injury and clinic functional manifestations of life-threatening phenomena. At the same time, diagnostic signs which must be used when determining the severity of physical injuries are the following: the presence of clinical and functional signs of acute respiratory failure, loss of part or all of the respiratory organ (lungs), dynamics and duration of recovery of post-traumatic morpho-functional changes injured organs.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"9 13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83549709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.11
P. Moldovan, T. Sorokman
Introduction. Duodenal ulcer in children is characterized by a significant prevalence, frequent development of serious complications and the need for large financial allocations for the implementation of treatment programs. Antimicrobial peptides have an immunomodulatory function and can be used as markers of the severity of the inflammatory process.Aim. To investigate the concentration of HNPs 1-3 and LL-37 in children with duodenal ulcer.Methods. A study of 47 children with duodenal ulcer, aged 7–18 years, was conducted with the determination of the CagA HR antigen in feces by enzyme-linked immunosorbent assay, the levels of HNPs 1-3 and LL-37 in blood plasma by enzyme-linked immunosorbent assay on the "PrisMatic" IN013 model 4301 analyzer test systems "MyBioSource, Inc.", USA. All children underwent a complex clinical and instrumental laboratory examination (topographic intragastric pH-metry, endoscopic examination with targeted biopsy for morphological examination and determination of HP). Results. 76.6% of people with DU were infected with HP. 80% had a toxigenic CagA strain of HP. In the vast majority of children with DU, small ulcerative defects were diagnosed. II and III degrees of inflammatory activity occurred with almost the same frequency (44.6% and 34% of people), while I degree occurred only in 21.3% of cases. The average level of HNP1-3 in children with DU was 46.56 ± 8.52 ng/ml, LL-37 - 269.9 ± 26.53 ng/ml. Direct probable connections between the levels of HNP1-3 and LL-37 and the severity of the course and the activity of the inflammatory process were established.Conclusion. Elevated levels of LL-37 and HNPs 1-3 were found in the blood plasma of children with duodenal ulcers associated with CagA strains of Helicobacter pylori. Significantly higher levels of LL-37 and HNPs 1-3 were registered with a severe course of the disease and an active inflammatory process, which indicates a direct influence of antimicrobial peptides on the course of the pathological process.
{"title":"The effect of endogenous antimicrobial peptides (HNPs1-3 and LL-37) on the course of duodenal ulcer in children","authors":"P. Moldovan, T. Sorokman","doi":"10.24061/2413-0737.xxvi.3.103.2022.11","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.11","url":null,"abstract":"Introduction. Duodenal ulcer in children is characterized by a significant prevalence, frequent development of serious complications and the need for large financial allocations for the implementation of treatment programs. Antimicrobial peptides have an immunomodulatory function and can be used as markers of the severity of the inflammatory process.Aim. To investigate the concentration of HNPs 1-3 and LL-37 in children with duodenal ulcer.Methods. A study of 47 children with duodenal ulcer, aged 7–18 years, was conducted with the determination of the CagA HR antigen in feces by enzyme-linked immunosorbent assay, the levels of HNPs 1-3 and LL-37 in blood plasma by enzyme-linked immunosorbent assay on the \"PrisMatic\" IN013 model 4301 analyzer test systems \"MyBioSource, Inc.\", USA. All children underwent a complex clinical and instrumental laboratory examination (topographic intragastric pH-metry, endoscopic examination with targeted biopsy for morphological examination and determination of HP). Results. 76.6% of people with DU were infected with HP. 80% had a toxigenic CagA strain of HP. In the vast majority of children with DU, small ulcerative defects were diagnosed. II and III degrees of inflammatory activity occurred with almost the same frequency (44.6% and 34% of people), while I degree occurred only in 21.3% of cases. The average level of HNP1-3 in children with DU was 46.56 ± 8.52 ng/ml, LL-37 - 269.9 ± 26.53 ng/ml. Direct probable connections between the levels of HNP1-3 and LL-37 and the severity of the course and the activity of the inflammatory process were established.Conclusion. Elevated levels of LL-37 and HNPs 1-3 were found in the blood plasma of children with duodenal ulcers associated with CagA strains of Helicobacter pylori. Significantly higher levels of LL-37 and HNPs 1-3 were registered with a severe course of the disease and an active inflammatory process, which indicates a direct influence of antimicrobial peptides on the course of the pathological process.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81617850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-27DOI: 10.24061/2413-0737.xxvi.3.103.2022.15
V. Sokol
Determining the time since death is a key issue for forensic authorities when working with a corpse at the scene of death. After all, it is precisely the accurate data provided by the forensic medical expert that makes it possible to answer important questions during the investigation of a crime. Despite the enormous amount of fundamental research conducted over many decades and devoted to the exact establishment of the time since death, this problem has not been solved yet. Despite the obtained promising results, most of the proposed methods were characterized as unreliable due to sensitivity to the influence of many external and internal modifying factors. In our opinion, it is promising to combine different methods of postmortem interval diagnostics for the simultaneous analysis of several components, which will allow taking into account various causes of death, pathological conditions and other factors that can influence the obtained result.
{"title":"Current state of the problem of forensic medical determination of the time since death (literature review)","authors":"V. Sokol","doi":"10.24061/2413-0737.xxvi.3.103.2022.15","DOIUrl":"https://doi.org/10.24061/2413-0737.xxvi.3.103.2022.15","url":null,"abstract":"Determining the time since death is a key issue for forensic authorities when working with a corpse at the scene of death. After all, it is precisely the accurate data provided by the forensic medical expert that makes it possible to answer important questions during the investigation of a crime. Despite the enormous amount of fundamental research conducted over many decades and devoted to the exact establishment of the time since death, this problem has not been solved yet. Despite the obtained promising results, most of the proposed methods were characterized as unreliable due to sensitivity to the influence of many external and internal modifying factors. In our opinion, it is promising to combine different methods of postmortem interval diagnostics for the simultaneous analysis of several components, which will allow taking into account various causes of death, pathological conditions and other factors that can influence the obtained result.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83469822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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