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Effect of adrenalectomy and glycemic status on caloric efficiency and adiposity in the congenic LA/Ntul//-cp (corpulent) rat 肾上腺切除术和血糖状态对先天性LA/Ntul/ -cp(肥胖)大鼠热效率和肥胖的影响
Pub Date : 2021-11-03 DOI: 10.15406/aowmc.2021.11.00352
O. Tulp, A. Awan, George P Einstein
Obesity develops in the obese phenotype of the congenic LA/Ntul//-cp (corpulent) rat strain by 6 weeks of age.1 To gain insight into the contributors to the expression of obesity in the obese phenotype of this strain, groups [n=12-20 rats/phenotype] of congenic male lean and obese LA/Ntul//-cp (corpulent) rats were fed an ad libitum standardized Purina chow diet (CHOW) from 6 to 12 weeks or age, and subgroups (n=6 rats / subgroup) were overfed with a highly palatable cafeteria diet (CAFÉ) from 9 to 12 weeks of age (WOA). A subgroup of obese rats (n=6) were subjected to bilateral adrenalectomy (ADX) at 6 WOA and followed the same dietary regimen and treatment schedule. BW of lean and obese animals were similar at 6 WOA and increased by 88% in lean phenotype and 281% in obese phenotype during the 6 weeks study, while in ADX obese rats, BW were similar at 6 and 9 WOA but BW increased to 2.5-fold above starting weights and 1.8-fold above 9-week weights between 9 and 12 WOA. The CAFE supplement was without significant effect on final body weights in the lean phenotypes, but was associated with significantly greater body weights at ages 9 and 12 WOA in the obese phenotype (p=<0.05) and in the obese-ADX at 12 WOA. CE (kcal/gram gain of BW per day) remained relatively constant in lean and obese-ADX rats throughout the study, but CE was more efficient in the obese phenotype at all ages studied and was more efficient with the CAFE supplement feeding regimen. Fasting I:G ratios at 12 weeks of age were 4.2-fold greater in obese than lean and were partially normalized in obese-ADX to 1.7-fold increase at 12 WOA. Relative adiposity of obese rats was 3.8-fold greater in obese than lean phenotype, with the greatest increase in the SQ depot. Resting VO2 (RMR) was lower in obese than lean rats at each age studied and was increased by ADX. Thermogenic interscapular brown adipose tissue (IBAT) mass was greater in obese and obese-ADX than lean rats. The results of this study indicate that CE is associated with the predisposition for the expression and development of adiposity in the obese phenotype of this strain and is associated with an increased I:G ratio and IBAT mass that is consistent with insulin resistance and an impaired capacity for energy expenditure and became normalized on the Chow but not the CAFE diet following ADX. These observations implicate likely multiple metabolic factors that contribute to a greater efficiency of energy storage, utilization and or energy conservation in the obese than in the lean phenotype of this strain and which is partially corrected in the obese phenotype by ADX. The metabolic impact of added caloric intake was associated with an additive impact on the CE of weight gain and adiposity in the obese phenotype of this congenic rodent strain and was partially corrected via ADX
基因LA/Ntul//-cp(肥胖)大鼠在6周龄时出现肥胖表型为了深入了解该品系肥胖表型中肥胖表达的因素,在6 - 12周龄(WOA)期间,将遗传雄性瘦肉和肥胖LA/Ntul//-cp(肥胖)大鼠[n=12-20只大鼠/表型]随意喂食标准化普瑞纳饲料(chow),亚组(n=6只大鼠/亚组)在9 - 12周龄(WOA)期间过量喂食高度美味的自助饮食(CAFÉ)。肥胖大鼠亚组(n=6)在6 WOA时接受双侧肾上腺切除术(ADX),并遵循相同的饮食方案和治疗计划。瘦肉和肥胖动物的体重在6 WOA时相似,在6周的研究期间,瘦肉表型和肥胖表型的体重分别增加了88%和281%,而ADX肥胖大鼠的体重在6和9 WOA时相似,但在9和12 WOA期间,体重增加到初始体重的2.5倍和9周体重的1.8倍。在瘦表型中,补充CAFE对最终体重没有显著影响,但在肥胖表型中,9岁和12 WOA时体重显著增加(p=<0.05),在肥胖- adx中,12 WOA时体重显著增加。在整个研究过程中,瘦肉大鼠和肥胖- adx大鼠的CE (kcal/g gain of BW / day)保持相对恒定,但CE在所有年龄的肥胖表型中都更有效,并且在CAFE补充喂养方案中更有效。12周龄时,肥胖的空腹I:G比值比瘦的高4.2倍,肥胖的空腹I:G比值在12 WOA时部分正常化至1.7倍。肥胖大鼠的相对肥胖表型比瘦型大3.8倍,SQ库增加最多。在研究的每个年龄,肥胖大鼠的静息VO2 (RMR)低于瘦大鼠,ADX使其升高。肥胖大鼠和肥胖- adx大鼠的产热性肩胛间棕色脂肪组织(IBAT)质量大于瘦大鼠。本研究的结果表明,CE与该品系肥胖表型中肥胖的表达和发展倾向有关,并与I:G比和IBAT质量的增加有关,这与胰岛素抵抗和能量消耗能力受损一致,并在ADX后在Chow饮食中恢复正常,而在CAFE饮食中则没有。这些观察结果表明,可能存在多种代谢因素,这些因素导致肥胖菌株的能量储存、利用和/或能量节约效率高于瘦型菌株,而ADX在肥胖表型中部分纠正了这一点。增加热量摄入的代谢影响与肥胖表型中体重增加和肥胖的累加性影响相关,并通过ADX部分纠正
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引用次数: 0
Concordance between body fat percentage stablished by bio impedance and estimation formulas based in anthropometric measurements 由生物阻抗建立的体脂百分比与基于人体测量的估算公式之间的一致性
Pub Date : 2021-10-11 DOI: 10.15406/aowmc.2021.11.00351
Llamosas-Senties Regina, Martinez Borja Livia, Ayala San Pedro J Alejandro
Obesity is one of the most important health issues worldwide. According to the Mexican National Survey of Health and Nutrition 2018 “ENSANUT”, 76.8% of women and 73% of men who are 18 years or older are overweight or obese, and the majority are not well diagnosed. One of the greatest difficulties in order to diagnose this disease is the poor correlation between the BMI and the real fat percentage. There are different ways to estimate the fat percentage. Some of them are the formulas based on anthropometric measures. We conducted a retrolective, descriptive, transversal trial to analyze the correlation between the fat percentage measured by bioelectrical impedance with In Body 230 and the one calculated with the Deurenberg, Lean, and CUN BAE formulas in Mexican adults. We analyzed 319 people, 111 men, and 208 women. The average age was 43.8, and 44.13 years, respectively. The average BMI for each gender was 36.5 kg/m2 and 33.8 kg/m2, and the average fat percentage was 38.23 and 45.53 respectively. We calculated de Pearson correlation index between fat percentage mesure by bioelectrical impedance and the one calculated by the formulas enlisted before. We also calculated the W/H and the average between the three formulas. The Pearson correlation index for Deurenberg’s formula was 0.71, for men and 0.816 for women. For Lean’s formula was 0.622 for men and 0.701 for women, and for CUN BAE’s formula 0.77for men, and 0.856 for women. All of them with estatistical significance (p<0.001). For the W/H was 0.702 (p<0.001) for men and 0.681 (p<0.001) for women, and for the average of the three formulas was 0.73 (p<0.001) for men and 0.828 (p<0.001) for women. In conclusion CUN BAE´s and Deurenberg’s formulas have a higher correlation with the fat percentage in both genders, and CUN BAE’s formula is the one with more correlation in women.
肥胖是全世界最重要的健康问题之一。根据2018年墨西哥全国健康与营养调查“ENSANUT”,76.8%的女性和73%的18岁及以上男性超重或肥胖,而且大多数人没有得到很好的诊断。为了诊断这种疾病,最大的困难之一是BMI和实际脂肪百分比之间的相关性很差。有不同的方法来估算脂肪百分比。其中一些是基于人体测量的公式。我们进行了一项回顾性、描述性、横向试验,以分析用In Body 230测量的生物电阻抗与用Deurenberg、Lean和CUN BAE公式计算的墨西哥成年人脂肪百分比之间的相关性。我们分析了319人,111名男性和208名女性。平均年龄分别为43.8岁和44.13岁。男女平均BMI分别为36.5 kg/m2和33.8 kg/m2,平均脂肪率分别为38.23和45.53。我们计算了生物电阻抗法测定脂肪百分比与之前公式计算脂肪百分比之间的de Pearson相关指数。我们还计算了三个公式之间的W/H和平均值。Deurenberg公式的Pearson相关指数男性为0.71,女性为0.816。Lean的公式中男性为0.622,女性为0.701,而CUN BAE的公式中男性为0.77,女性为0.856。差异均有统计学意义(p<0.001)。男性的W/H为0.702 (p<0.001),女性为0.681 (p<0.001),三种公式的平均值为0.73 (p<0.001),女性为0.828 (p<0.001)。综上所述,在两性中,CUN BAE公式和Deurenberg公式与脂肪率的相关性较高,其中在女性中,CUN BAE公式的相关性更强。
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引用次数: 0
Obesity in postmenopausal women: causes, prevalence and specific risks: role of decreased 绝经后妇女肥胖:原因、流行和具体风险:减少的作用
Pub Date : 2021-10-05 DOI: 10.15406/aowmc.2021.11.00350
C. Vázquez, B. Luca, J. Cardenas, Álvaro Sánchez, T. Montoya, Paula Labeira, Belén Gutiérrez, Y. Fernández, Roberto Sierra, D. Meneses
Obesity is one of the most important health issues worldwide. According to the Mexican National Survey of Health and Nutrition 2018 “ENSANUT”, 76.8% of women and 73% of men who are 18 years or older are overweight or obese, and the majority are not well diagnosed. One of the greatest difficulties in order to diagnose this disease is the poor correlation between the BMI and the real fat percentage. There are different ways to estimate the fat percentage. Some of them are the formulas based on anthropometric measures. We conducted a retrolective, descriptive, transversal trial to analyze the correlation between the fat percentage measured by bioelectrical impedance with In Body 230 and the one calculated with the Deurenberg, Lean, and CUN BAE formulas in Mexican adults. We analyzed 319 people, 111 men, and 208 women. The average age was 43.8, and 44.13 years, respectively. The average BMI for each gender was 36.5 kg/m2 and 33.8 kg/m2, and the average fat percentage was 38.23 and 45.53 respectively. We calculated de Pearson correlation index between fat percentage mesure by bioelectrical impedance and the one calculated by the formulas enlisted before. We also calculated the W/H and the average between the three formulas. The Pearson correlation index for Deurenberg’s formula was 0.71, for men and 0.816 for women. For Lean’s formula was 0.622 for men and 0.701 for women, and for CUN BAE’s formula 0.77for men, and 0.856 for women. All of them with estatistical significance (p<0.001). For the W/H was 0.702 (p<0.001) for men and 0.681 (p<0.001) for women, and for the average of the three formulas was 0.73 (p<0.001) for men and 0.828 (p<0.001) for women. In conclusion CUN BAE´s and Deurenberg’s formulas have a higher correlation with the fat percentage in both genders, and CUN BAE’s formula is the one with more correlation in women.
肥胖是全世界最重要的健康问题之一。根据2018年墨西哥全国健康与营养调查“ENSANUT”,76.8%的女性和73%的18岁及以上男性超重或肥胖,而且大多数人没有得到很好的诊断。为了诊断这种疾病,最大的困难之一是BMI和实际脂肪百分比之间的相关性很差。有不同的方法来估算脂肪百分比。其中一些是基于人体测量的公式。我们进行了一项回顾性、描述性、横向试验,以分析用In Body 230测量的生物电阻抗与用Deurenberg、Lean和CUN BAE公式计算的墨西哥成年人脂肪百分比之间的相关性。我们分析了319人,111名男性和208名女性。平均年龄分别为43.8岁和44.13岁。男女平均BMI分别为36.5 kg/m2和33.8 kg/m2,平均脂肪率分别为38.23和45.53。我们计算了生物电阻抗法测定脂肪百分比与之前公式计算脂肪百分比之间的de Pearson相关指数。我们还计算了三个公式之间的W/H和平均值。Deurenberg公式的Pearson相关指数男性为0.71,女性为0.816。Lean的公式中男性为0.622,女性为0.701,而CUN BAE的公式中男性为0.77,女性为0.856。差异均有统计学意义(p<0.001)。男性的W/H为0.702 (p<0.001),女性为0.681 (p<0.001),三种公式的平均值为0.73 (p<0.001),女性为0.828 (p<0.001)。综上所述,在两性中,CUN BAE公式和Deurenberg公式与脂肪率的相关性较高,其中在女性中,CUN BAE公式的相关性更强。
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引用次数: 2
Pre-operative direct and inverse clinical characteristic variations by age do not resolve up to 24 months following open roux-en-y gastric bypass 术前直接和逆临床特征变化的年龄不解决后24个月开放胃旁路
Pub Date : 2021-10-04 DOI: 10.15406/aowmc.2021.11.00349
A. Menon, David T. Kelter, Gus J Slotman
Background: Today open Roux-en-Y gastric bypass (ORYGB) is reserved for abdomens too complex or obesity too severe for laparoscopic surgery. However, outcomes by age in ORYGB are unknown. Objective: Identify variation by age in ORYGB patients. Setting: Independent database. Methods: 5389 ORYGB BOLD patients was analyzed retrospectively by age: <30 (591), 30-40 (1252), 40-50 (1527), 50-60 (1388), 60-70 (592) and >70 (39). Statistics: ANOVA/general linear model. Results: Baseline female/male (p<0.01), weight, BMI, African-American, Hispanic, Medicaid, Private insurance, self-pay (p<0.0001), PCOS, PTC (n=10) varied inversely with age. Medicare, CHF, HTN, angina, LEE, PVD, IHD, dyslipidemia, OHS, diabetes, gout, IFS, and unemployment varied directly. Caucasian, Asian, Other race, DVT/PE, hernia, cholelithiasis, GERD, panniculitis, liver disease, SUI, MSP, fibromyalgia, alcohol and tobacco abuse, depression, PI, MHD (n=17) vary non-linearly. At 12 months, in spite of equal BMI by age, CHF, HTN, angina, PVD, dyslipidemia, cholelithiasis, SUI, diabetes, gout, IFS (n=10) varied directly. PCOS and PTC varied inversely, and LEE, OSA, hernia, MSP, tobacco abuse, depression, MHD varied non-linearly. 24 months CHF, HTN, angina, dyslipidemia, diabetes, IFS, and MSP vary directly. PTC and tobacco abuse varied inversely. LEE, OSA, PHTN, hernia, PCOS, and tobacco abuse varied non-linearly. Conclusions: ORYGB patients vary dramatically by decade of age. Pre-operatively 10 co-morbidities varied inversely, 13 directly, and 17 non-linearly by age. In spite of equal BMI by age at 24 months, important co-morbidities CHF, HTN, angina, dyslipidemia, diabetes varied directly, tobacco inversely, and OSA non-linearly. This advance clinical knowledge of age variation can aid ORYGB management
背景:目前开放式Roux-en-Y胃旁路术(ORYGB)是为腹腔过于复杂或肥胖过于严重而不适合腹腔镜手术而保留的。然而,不同年龄的ORYGB的结果是未知的。目的:探讨ORYGB患者的年龄差异。设置:独立数据库。方法:回顾性分析5389例ORYGB BOLD患者,年龄70岁(39岁)。统计学:方差分析/一般线性模型。结果:基线女性/男性(p<0.01)、体重、BMI、非裔美国人、西班牙裔、医疗补助、私人保险、自付(p<0.0001)、PCOS、PTC (n=10)与年龄呈负相关。医疗保险、CHF、HTN、心绞痛、LEE、PVD、IHD、血脂异常、OHS、糖尿病、痛风、IFS和失业率直接不同。白种人、亚洲人、其他种族、DVT/PE、疝气、胆石症、胃食管反流、泛膜炎、肝病、SUI、MSP、纤维肌痛、酗酒和吸烟、抑郁症、PI、MHD (n=17)呈非线性变化。在12个月时,尽管按年龄BMI相等,但CHF、HTN、心绞痛、PVD、血脂异常、胆石症、SUI、糖尿病、痛风、IFS (n=10)直接变化。PCOS与PTC呈负相关,LEE、OSA、疝、MSP、吸烟、抑郁、MHD呈非线性变化。24个月CHF、HTN、心绞痛、血脂异常、糖尿病、IFS和MSP直接变化。PTC与烟草滥用呈负相关。LEE、OSA、PHTN、疝气、PCOS和烟草滥用呈非线性变化。结论:ORYGB患者在不同年龄阶段差异显著。术前10例合并症呈负相关,13例呈正相关,17例随年龄呈非线性变化。尽管24月龄时BMI相等,但重要的合并症CHF、HTN、心绞痛、血脂异常、糖尿病直接变化,烟草呈负相关,OSA呈非线性变化。这种年龄变化的先进临床知识可以帮助ORYGB的管理
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引用次数: 0
Short-chain fatty acids: nutritional strategies to modulate intestinal microbiota 短链脂肪酸:调节肠道微生物群的营养策略
Pub Date : 2021-09-29 DOI: 10.15406/aowmc.2021.11.00348
Marcos Porto Arrais de Souza, Morgana Andrade Freitas, Carla Braga Campelo de Oliveira, Lorena Almeida Brito, J. C. C. Nunes Filho, Marilia Porto Oliveira Nunes, Juliana Magalhaes da Cunha Rego, Richele J. A. Machado
Introduction: The intestinal microbiota has been the subject of research due to its association in physiological and pathological conditions. The production of short chain fatty acids obtained by fermentation of the intestinal microbiota has shown important effects on the gastrointestinal tract, adipose tissue, immune system and nervous system. Objective: This literature review aims to present different nutritional strategies with the potential to modulate the intestinal microbiota by increasing the production of short chain fatty acids. Methods: The research was considered a review work, through a bibliographic survey carried out from the collection of articles in English, published in the PubMed database, in the period from 2013 to 2020. The articles were selected from the descriptors: gut microbiota, soluble fiber, resistent starch, pectin, dietary fiber, short chain fatty acids (SCFA) with the combinations of the Boolean operators “and” and “or”. Studies considered as gray literature were excluded, as well as studies in which the titles were not related to the theme of the proposed research. Results: There are many benefits to consuming foods that may favor the increase of short chain fatty acids. This increase in the gastrointestinal tract is of fundamental importance for the maintenance of intestinal microbiota and prevention of diseases. Some nutritional strategies can be used in clinical therapy, such as increased consumption of fruits, vegetables and whole grains that are plant foods and important sources of fiber. The type of food must be observed, since each one can contain fibers of diverse types. Soluble fiber is the basis for the metabolization of short chain fatty acids and is found in various foods that can be inserted into the food plan, such as: bananas, apples, oats, barley, cooked and cooled potatoes, partially ground seeds, corn, morning cereal, agave, artichoke, asparagus, chicory root, garlic, onion, leeks and wheat. Conclusion: Scientific evidence of the relationship between nutrition, intestinal microbiota and short-chain fatty acid production demonstrates the importance of implementing simple nutritional strategies by health professionals, which can contribute to the modulation of the intestinal microbiota and the development of new perspectives in the development of therapies for prevention and treatment of diseases.
肠道微生物群因其与生理和病理状况的关联而成为研究的主题。肠道菌群发酵产生的短链脂肪酸对胃肠道、脂肪组织、免疫系统和神经系统都有重要作用。目的:本文献综述旨在提出不同的营养策略,通过增加短链脂肪酸的产生来调节肠道微生物群。方法:本研究是一项综述性工作,通过对PubMed数据库2013年至2020年期间发表的英文文章进行书目调查。从肠道菌群、可溶性纤维、抗性淀粉、果胶、膳食纤维、短链脂肪酸(SCFA)等描述词中选择文章,并使用布尔运算符“and”和“or”组合。被认为是灰色文献的研究被排除在外,以及标题与拟议研究主题无关的研究。结果:食用可能有利于增加短链脂肪酸的食物有许多好处。这种胃肠道的增加对于维持肠道微生物群和预防疾病至关重要。一些营养策略可用于临床治疗,如增加水果、蔬菜和全谷物的消费,这些都是植物性食物和重要的纤维来源。必须注意食物的种类,因为每一种食物都可能含有不同种类的纤维。可溶性纤维是短链脂肪酸代谢的基础,存在于各种食物中,可以插入到食物计划中,例如:香蕉、苹果、燕麦、大麦、煮熟和冷却的土豆、部分磨碎的种子、玉米、早餐麦片、龙舌兰、朝鲜蓟、芦笋、菊苣根、大蒜、洋葱、韭菜和小麦。结论:营养、肠道菌群和短链脂肪酸生成之间关系的科学证据表明,卫生专业人员实施简单的营养策略非常重要,这有助于调节肠道菌群,并为疾病预防和治疗的疗法开发提供新的视角。
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引用次数: 0
Photobiomodulation: a potential adjunctive obesity intervention a review 光生物调节:潜在的辅助性肥胖干预综述
Pub Date : 2021-09-07 DOI: 10.15406/aowmc.2021.11.00347
R. Marks
Obesity, a largely intractable health condition with incalculable health and financial and social costs and ramifications remains an immense challenge to mitigate effectively. Multiple interventions to offset obesity, while studied and implemented for many years, have generally failed to eliminate this growing global epidemic. Alternately, interventions that can offer hope, especially to those who are physically as well as emotionally challenged, with negative outcome expectations, would appear of high significance. Studied for over 40 years, various forms of light therapy are proving to be of possible adjunctive benefit in efforts to reduce excess weight. This mini review discusses some findings regarding photobiomodulation or light therapy and whether more intense study and evaluation will improve the overall obesity burden and outlook. Extracted from current literature, it is concluded that this is a field of significant promise
肥胖是一种非常棘手的健康状况,其健康、经济和社会成本和后果难以估量,仍然是有效缓解的巨大挑战。针对肥胖的多种干预措施虽然研究和实施了多年,但总体上未能消除这一日益严重的全球流行病。另外,能够提供希望的干预措施,特别是对那些身体和情感上都有挑战、对结果有负面预期的人来说,将显得非常重要。经过40多年的研究,各种形式的光疗被证明在减轻体重方面可能具有辅助作用。这篇综述讨论了一些关于光生物调节或光疗法的发现,以及更深入的研究和评估是否会改善整体肥胖负担和前景。从目前的文献中可以得出结论,这是一个具有重大前景的领域
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引用次数: 4
Association between type of cooking fuel and body mass index among women in Cambodia 柬埔寨妇女烹饪燃料类型与体重指数之间的关系
Pub Date : 2021-08-31 DOI: 10.15406/aowmc.2021.11.00346
H. Rowles
Introduction: Solid cooking fuel is the primary source of energy for almost half of the world’s population. Studies have examined the association between solid cooking fuel and respiratory and cardiovascular disease, negative pregnancy outcomes, and shortened life expectancy. However, no study has examined the association between solid cooking fuel and Body Mass Index (BMI) among women in Cambodia. Methods: Data was taken from the 2014 Cambodia Demographic and Health Survey (N=3249), women aged 15-49 years. Multivariable logistic regression analysis was used to determine the association between type of cooking fuel and BMI, controlling for age, education, marital status, parity, employment status, kitchen being a separate room, location of cooking food, and household wealth index. Results: Compared to younger women, older women were more likely to be overweight/obese shown by multivariable adjusted odds ratio (95% confidence interval) for women aged 25-34 years 2.64 (1.80, 3.86), and for women aged 35-49 years 4.97 (3.20, 7.72). Compared to women who reside in poor households, the odds of being overweight/obese were higher for women residing in a middle household wealth index 2.62 (1.52, 4.52), and women residing in rich household wealth index 2.78 (1.83, 4.24). When adjusting for potential confounding variables, the association between type of cooking fuel and BMI observed in the unadjusted model disappeared (p = 0.103). Conclusion: These findings indicate that type of cooking fuel is not significantly associated with BMI in a nationally representative sample of women in Cambodia.
导言:固体烹饪燃料是世界上近一半人口的主要能源。研究调查了固体烹饪燃料与呼吸系统和心血管疾病、不良妊娠结局以及预期寿命缩短之间的关系。然而,没有研究调查了柬埔寨妇女的固体烹饪燃料与体重指数(BMI)之间的关系。方法:数据来自2014年柬埔寨人口与健康调查(N=3249),年龄在15-49岁之间。采用多变量logistic回归分析确定烹饪燃料类型与BMI之间的关系,控制了年龄、教育程度、婚姻状况、性别、就业状况、厨房是否为独立房间、烹饪食物的位置和家庭财富指数。结果:与年轻女性相比,年龄较大的女性更容易超重/肥胖,25-34岁女性的多变量校正比值比(95%置信区间)为2.64(1.80,3.86),35-49岁女性的比值比为4.97(3.20,7.72)。与贫困家庭的女性相比,中等家庭财富指数为2.62(1.52,4.52),富裕家庭财富指数为2.78(1.83,4.24)的女性超重/肥胖的几率更高。当调整潜在的混杂变量时,未调整模型中观察到的烹饪燃料类型与BMI之间的关联消失(p = 0.103)。结论:这些发现表明,在柬埔寨具有全国代表性的妇女样本中,烹饪燃料的类型与BMI没有显著关联。
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引用次数: 0
Residual thermic effects of diet induced thermogenesis (RDIT) in aging lean and obese LA/Ntu1//-cp (corpulent) rats LA/Ntu1//-cp(肥胖)大鼠的残热效应
Pub Date : 2021-08-23 DOI: 10.15406/aowmc.2021.11.00345
O. Tulp, S. DeBolt, A. Awan, G. Einstein
Diet induced thermogenesis has been proposed to account for up to 15% of the caloric content of an ingested meal and to become decreased with aging and in obesity. Genetically obese rodents have been shown to exhibit impairments in the thermic responses to diet and environment, which may partially account for an improved caloric efficiency and to contribute to their increased propensity to become obese. In the present study we sought to determine the thermic responses to diet and environment in aging obese rats when young, middle aged, and aged. Resting oxygen consumption tended to decrease with advancing age and the thermic responses were lower than predicted in obese than in lean rats. This study provides important new insights regarding the thermogenic effects of diet and diet induced thermogenesis and their potential contributions to mechanisms of energy balance across the spectrum of aging in lean and obese LA/Ntul//-cp rats
饮食引起的产热已被认为占摄入膳食热量含量的15%,并随着年龄和肥胖而减少。基因肥胖的啮齿动物在对饮食和环境的热反应中表现出损伤,这可能部分解释了热量效率的提高,并有助于它们增加肥胖的倾向。在本研究中,我们试图确定衰老肥胖大鼠在年轻、中年和老年时对饮食和环境的热反应。静息耗氧量随着年龄的增长而下降,肥胖大鼠的热反应比瘦大鼠低。本研究为LA/Ntul//-cp大鼠饮食和饮食诱导的产热作用及其在衰老过程中能量平衡机制的潜在贡献提供了重要的新见解
{"title":"Residual thermic effects of diet induced thermogenesis (RDIT) in aging lean and obese LA/Ntu1//-cp (corpulent) rats","authors":"O. Tulp, S. DeBolt, A. Awan, G. Einstein","doi":"10.15406/aowmc.2021.11.00345","DOIUrl":"https://doi.org/10.15406/aowmc.2021.11.00345","url":null,"abstract":"Diet induced thermogenesis has been proposed to account for up to 15% of the caloric content of an ingested meal and to become decreased with aging and in obesity. Genetically obese rodents have been shown to exhibit impairments in the thermic responses to diet and environment, which may partially account for an improved caloric efficiency and to contribute to their increased propensity to become obese. In the present study we sought to determine the thermic responses to diet and environment in aging obese rats when young, middle aged, and aged. Resting oxygen consumption tended to decrease with advancing age and the thermic responses were lower than predicted in obese than in lean rats. This study provides important new insights regarding the thermogenic effects of diet and diet induced thermogenesis and their potential contributions to mechanisms of energy balance across the spectrum of aging in lean and obese LA/Ntul//-cp rats","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85712636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity years: clinical variation by age pre/post biliopancreatic diversion/duodenal switch (BPD/DS) 肥胖年:不同年龄的临床变化胆管分流/十二指肠转换(BPD/DS)前/后
Pub Date : 2021-07-26 DOI: 10.15406/aowmc.2021.11.00343
ML Gott, PR Osterdahl, LD Perry, GJ Slotman
Objective: To identify clinical variation by age, pre/post BPD/DS. Methods: 1673 BPD/DS patients from the Surgical Review Corporation’s BOLD database were analyzed retrospectively by age: <30(177), 30-40(456), 40-50(486), 50-60(407), 60-70(138), >70(9). Data: Demographics, BMI and 33 obesity co-morbidities. Statistics: ANOVA and General Linear Models including pre- and post-operative data modified for binomial distribution of dichotomous variables. Results: Pre-op BMI varied inversely by age and continued through to 12 months post operatively. Gout varied directly and tobacco abuse inversely by age at baseline. The incidence of 12 of the 33 obesity-co-morbidities increased directly with age up to 12 months post operatively. In >60 patients, angina, MS pain, LEE and SUI increased from baseline after undergoing BPD/DS. Conclusion: Despite lower pre-operative and 12-month BMI in older BPD/DS patients, baseline co-morbidities varied directly with age, and post-operative resolution of 12 weight-related problems was inversely proportional to age. Only diabetes resolved better among older patients. These findings suggest the concept of “obesity years”, wherein patients carrying obesity the longest accumulate more co-morbidities and resolve them less.
目的:确定不同年龄、BPD/DS前后的临床差异。方法:回顾性分析来自Surgical Review Corporation的BOLD数据库的1673例BPD/DS患者,年龄为70岁(9)。数据:人口统计学、BMI和33例肥胖合并症。统计学:方差分析和一般线性模型,包括术前和术后的数据修改二项分布的变量。结果:术前BMI随年龄呈负相关,并持续至术后12个月。痛风与烟草滥用在基线年龄成正比。33例肥胖合并症中有12例的发病率随着年龄的增长而直接增加,直至术后12个月。在>60例患者中,BPD/DS术后心绞痛、MS疼痛、LEE和SUI较基线增加。结论:尽管老年BPD/DS患者术前和12个月BMI较低,但基线合并症与年龄直接相关,术后12个体重相关问题的解决与年龄成反比。只有糖尿病在老年患者中得到较好的解决。这些发现提出了“肥胖年”的概念,即肥胖时间最长的患者积累了更多的合并症,而解决这些合并症的时间却更少。
{"title":"Obesity years: clinical variation by age pre/post biliopancreatic diversion/duodenal switch (BPD/DS)","authors":"ML Gott, PR Osterdahl, LD Perry, GJ Slotman","doi":"10.15406/aowmc.2021.11.00343","DOIUrl":"https://doi.org/10.15406/aowmc.2021.11.00343","url":null,"abstract":"Objective: To identify clinical variation by age, pre/post BPD/DS. Methods: 1673 BPD/DS patients from the Surgical Review Corporation’s BOLD database were analyzed retrospectively by age: <30(177), 30-40(456), 40-50(486), 50-60(407), 60-70(138), >70(9). Data: Demographics, BMI and 33 obesity co-morbidities. Statistics: ANOVA and General Linear Models including pre- and post-operative data modified for binomial distribution of dichotomous variables. Results: Pre-op BMI varied inversely by age and continued through to 12 months post operatively. Gout varied directly and tobacco abuse inversely by age at baseline. The incidence of 12 of the 33 obesity-co-morbidities increased directly with age up to 12 months post operatively. In >60 patients, angina, MS pain, LEE and SUI increased from baseline after undergoing BPD/DS. Conclusion: Despite lower pre-operative and 12-month BMI in older BPD/DS patients, baseline co-morbidities varied directly with age, and post-operative resolution of 12 weight-related problems was inversely proportional to age. Only diabetes resolved better among older patients. These findings suggest the concept of “obesity years”, wherein patients carrying obesity the longest accumulate more co-morbidities and resolve them less.","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84854077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can epigenetic expression contribute to the development of an obese phenotype? 表观遗传表达是否有助于肥胖表型的发展?
Pub Date : 2021-07-22 DOI: 10.15406/aowmc.2021.11.00342
Orien L Tulp, Aftab Awan, Nasheria Lewis, George P Einstein
Human obesity results from prolonged caloric imbalance, where energy intake exceeds energy expenditure over a period of months to years. It is presumed to occur as a consequence of complex interactions between environmental and heritable factors, although the search for which specific metabolic factors or genes persist has been challenging and remains incomplete. Despite a relatively high heritability of common forms of obesity which represents between 40 to 70 % of the obese population, the identification and conformation of definitive genetic or epigenetic obesogenic variants that when activated may contribute to a susceptibility for excess weight gain have been difficult to confirm. The incidence of obesity, overweight conditions, and their close association with hypertension in the US is increasing at alarming if not epidemic proportions throughout much of Western culture and society in recent history. Despite marked advances in nutrition knowledge and practice, pharmacotherapeutic management, and life-style modifications, approximately one third of the US population is now overweight, and the resulting predicted increases in the cost of medical management of overweight and obese conditions and their commonly associated pathophysiologic sequalae are becoming burdensome to public health and to the medical community. The development of obesity in most humans typically develops gradually over a duration of months to years but occurs more rapidly in onset in most commonly studied genetic models of obesity, where it usually follows the expression of an autosomal recessive genetic trait. In humans garden variety obesity is typically attributed to a combination of incompletely defined genetically linked traits and environmental factors.
人类肥胖是由于长期的热量不平衡造成的,在几个月到几年的时间里,能量摄入超过了能量消耗。据推测,这是环境因素和遗传因素之间复杂相互作用的结果,尽管寻找哪些特定的代谢因素或基因持续存在一直具有挑战性,而且仍然不完整。尽管常见形式的肥胖具有相对较高的遗传性,占肥胖人群的40%至70%,但确定的遗传或表观遗传致肥变异的识别和构象在激活时可能导致体重增加的易感性,这一点很难得到证实。在美国,肥胖、超重的发病率及其与高血压的密切关系,在近代西方文化和社会中,即使不是流行病,也正在以惊人的比例增加。尽管在营养知识和实践、药物治疗管理和生活方式改变方面取得了显著进步,但现在约有三分之一的美国人口超重,由此导致的超重和肥胖状况的医疗管理成本的预测增加及其通常相关的病理生理后遗症正在成为公共卫生和医学界的负担。大多数人的肥胖通常在几个月到几年的时间内逐渐发展,但在最常见的肥胖遗传模型中,肥胖的发病速度更快,通常伴随着常染色体隐性遗传特征的表达。在人类中,普通肥胖通常归因于不完全定义的遗传相关特征和环境因素的结合。
{"title":"Can epigenetic expression contribute to the development of an obese phenotype?","authors":"Orien L Tulp, Aftab Awan, Nasheria Lewis, George P Einstein","doi":"10.15406/aowmc.2021.11.00342","DOIUrl":"https://doi.org/10.15406/aowmc.2021.11.00342","url":null,"abstract":"Human obesity results from prolonged caloric imbalance, where energy intake exceeds energy expenditure over a period of months to years. It is presumed to occur as a consequence of complex interactions between environmental and heritable factors, although the search for which specific metabolic factors or genes persist has been challenging and remains incomplete. Despite a relatively high heritability of common forms of obesity which represents between 40 to 70 % of the obese population, the identification and conformation of definitive genetic or epigenetic obesogenic variants that when activated may contribute to a susceptibility for excess weight gain have been difficult to confirm. The incidence of obesity, overweight conditions, and their close association with hypertension in the US is increasing at alarming if not epidemic proportions throughout much of Western culture and society in recent history. Despite marked advances in nutrition knowledge and practice, pharmacotherapeutic management, and life-style modifications, approximately one third of the US population is now overweight, and the resulting predicted increases in the cost of medical management of overweight and obese conditions and their commonly associated pathophysiologic sequalae are becoming burdensome to public health and to the medical community. The development of obesity in most humans typically develops gradually over a duration of months to years but occurs more rapidly in onset in most commonly studied genetic models of obesity, where it usually follows the expression of an autosomal recessive genetic trait. In humans garden variety obesity is typically attributed to a combination of incompletely defined genetically linked traits and environmental factors.","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"218 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85543976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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Advances in obesity, weight management & control
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