首页 > 最新文献

Advances in obesity, weight management & control最新文献

英文 中文
Successful management with GLP-1 agonists in postprandial hyperinsulinemic hypoglycemia after roux-en-y gastric bypass: clinical case descriptionand review of the literature GLP-1激动剂成功治疗胃旁路术后餐后高胰岛素性低血糖:临床病例描述和文献回顾
Pub Date : 2019-06-04 DOI: 10.15406/aowmc.2019.09.00278
Evelyn Dorado, G. Guzman, O. Jimenez
Introduction: Obesity is a global pandemic, in Colombia 49% of the adult population is morbidly overweight or obese. Bariatric surgery has proved to be the most effective long-term treatment for the management of morbid obesity and resolution of comorbidities metabolic and mechanical. Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is related to postprandial hyperinsulinemic hypoglycemia (PPH). This condition can occur up to 70% of patients with gastric resections and generate much morbidity to the patient. Main : To describe the use of GLP-1 analogs in the management of patients with PPH secondary to bariatric surgery Methods : To describe a case of a patient with severe dumping referred for surgical reversion due to refractoriness to the extrainstitutional medical management. Results: patient with severe hypoglycemia post LRYGB with 17 Sigstad score, 2 years of evolution with impairment of quality of life, is referred for interdisciplinary management in the obesity clinic of our institution. We starts with Anatomical and physiological studies of their surgery, nutritional assessment, and endocrinology initiates liraglutide with improvement of 80% of the symptoms. Conclusion : In LRYGB patients with hypoglycemia, HHP, nesidioblastosis and insulinoma should be ruled out as a diagnosis. The presence of wide anastomoses that allow fast gastric emptying, high carbohydrate foods favor the symptoms. The use of GLP-1 analogs together with dietary measures have shown that they improve symptoms and quality of life in the long term, apparently these results are due to the stabilization of insulin peaks and delayed gastric emptying.
肥胖症是一种全球性的流行病,在哥伦比亚,49%的成年人超重或肥胖。减肥手术已被证明是治疗病态肥胖和解决代谢和机械合并症最有效的长期治疗方法。腹腔镜Roux-en-Y胃旁路术(LRYGB)与餐后高胰岛素性低血糖(PPH)有关。这种情况可在胃切除术患者中发生高达70%,并对患者产生很大的发病率。主要:描述GLP-1类似物在减肥手术继发PPH患者管理中的应用方法:描述一例因机构外医疗管理难治性而转诊的严重倾倒患者的手术逆转。结果:LRYGB术后严重低血糖患者,Sigstad评分17分,病情发展2年,生活质量受损,转介至我院肥胖门诊进行跨学科管理。我们从解剖和生理研究他们的手术,营养评估和内分泌学开始利拉鲁肽改善80%的症状。结论:在LRYGB患者中,应排除低血糖、HHP、肾母细胞病和胰岛素瘤。吻合口宽,胃排空快,高碳水化合物食物有利于症状。GLP-1类似物与饮食措施一起使用表明,它们可以长期改善症状和生活质量,显然这些结果是由于胰岛素峰值的稳定和胃排空的延迟。
{"title":"Successful management with GLP-1 agonists in postprandial hyperinsulinemic hypoglycemia after roux-en-y gastric bypass: clinical case descriptionand review of the literature","authors":"Evelyn Dorado, G. Guzman, O. Jimenez","doi":"10.15406/aowmc.2019.09.00278","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00278","url":null,"abstract":"Introduction: Obesity is a global pandemic, in Colombia 49% of the adult population is morbidly overweight or obese. Bariatric surgery has proved to be the most effective long-term treatment for the management of morbid obesity and resolution of comorbidities metabolic and mechanical. Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is related to postprandial hyperinsulinemic hypoglycemia (PPH). This condition can occur up to 70% of patients with gastric resections and generate much morbidity to the patient. Main : To describe the use of GLP-1 analogs in the management of patients with PPH secondary to bariatric surgery Methods : To describe a case of a patient with severe dumping referred for surgical reversion due to refractoriness to the extrainstitutional medical management. Results: patient with severe hypoglycemia post LRYGB with 17 Sigstad score, 2 years of evolution with impairment of quality of life, is referred for interdisciplinary management in the obesity clinic of our institution. We starts with Anatomical and physiological studies of their surgery, nutritional assessment, and endocrinology initiates liraglutide with improvement of 80% of the symptoms. Conclusion : In LRYGB patients with hypoglycemia, HHP, nesidioblastosis and insulinoma should be ruled out as a diagnosis. The presence of wide anastomoses that allow fast gastric emptying, high carbohydrate foods favor the symptoms. The use of GLP-1 analogs together with dietary measures have shown that they improve symptoms and quality of life in the long term, apparently these results are due to the stabilization of insulin peaks and delayed gastric emptying.","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"431 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77509591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity and sleep apnea 肥胖和睡眠呼吸暂停
Pub Date : 2019-05-27 DOI: 10.15406/aowmc.2019.09.00277
Saman Zaman
People who are obese also suffer in their sleep, usually they have shorter sleep duration as compared to people of non-obese category. The quality as well as quantity both are affected. Obesity becomes a major risk factor for development of a type of sleep disorder called Obstructive Sleep Apnea (OSA) and progression. OSA is defined as intermittent or complete upper airway collapse while a person is in sleep, which leads to fragmentation in sleep, decreased levels of bloody oxygen (also known as hypoxemia), increased levels of carbon dioxide (CO2 hypercapnia), intrathoracic pressure oscillations and increased sympathetic activity. The diagnosis and severity of this disease is based on Apnea Hypoapnea Index (AHI). AHI between 5 and 15 is termed as mild OSA, between 15 and 30 is called as moderate OSA and >30 is known as severe OSA. Since the awareness of this sleep disorder is less amongst the population, 80% of the OSA cases go undiagnosed.1–4
肥胖者的睡眠也会受到影响,通常他们的睡眠时间比非肥胖者短。质量和数量都受到影响。肥胖成为一种被称为阻塞性睡眠呼吸暂停(OSA)的睡眠障碍发展和发展的主要风险因素。OSA被定义为人在睡眠中间歇性或完全性上呼吸道塌陷,导致睡眠中断、血氧水平降低(也称为低氧血症)、二氧化碳水平升高(二氧化碳高碳酸血症)、胸内压力振荡和交感神经活动增加。这种疾病的诊断和严重程度是基于呼吸暂停低呼吸指数(AHI)。AHI在5到15之间被称为轻度OSA,在15到30之间被称为中度OSA, >30被称为重度OSA。由于对这种睡眠障碍的认识在人群中较少,80%的阻塞性睡眠呼吸暂停病例未被诊断
{"title":"Obesity and sleep apnea","authors":"Saman Zaman","doi":"10.15406/aowmc.2019.09.00277","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00277","url":null,"abstract":"People who are obese also suffer in their sleep, usually they have shorter sleep duration as compared to people of non-obese category. The quality as well as quantity both are affected. Obesity becomes a major risk factor for development of a type of sleep disorder called Obstructive Sleep Apnea (OSA) and progression. OSA is defined as intermittent or complete upper airway collapse while a person is in sleep, which leads to fragmentation in sleep, decreased levels of bloody oxygen (also known as hypoxemia), increased levels of carbon dioxide (CO2 hypercapnia), intrathoracic pressure oscillations and increased sympathetic activity. The diagnosis and severity of this disease is based on Apnea Hypoapnea Index (AHI). AHI between 5 and 15 is termed as mild OSA, between 15 and 30 is called as moderate OSA and >30 is known as severe OSA. Since the awareness of this sleep disorder is less amongst the population, 80% of the OSA cases go undiagnosed.1–4","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80665678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of vitamin D status and thyroid function among type 2 diabetic mellitus patients 2型糖尿病患者维生素D水平与甲状腺功能的关系
Pub Date : 2019-05-24 DOI: 10.15406/aowmc.2019.09.00276
K. Aljabri
Vitamin D is an important element for skeletal health and it may also affect extra-skeletal health such as association with autoimmune diseases.1–5 Inclusive studies in have reported an association between thyroid autoimmunity and 25-hydroxyvitamin D (25-OHD).6–8 Type 2 diabetes mellitus (T2DM) prevalence in Saudi Arabia is high, reaching up to 30%.9 Vitamin D deficiency (VDD) remains a major health problem.10 VDD has received special attention lately because of its high incidence and its implication in the genesis of multiple chronic illnesses. The high prevalence of VDD in general population underlines the fact that VDD is more common in chronic diseases like diabetes mellitus.
维生素D是骨骼健康的重要元素,它也可能影响骨骼外的健康,比如与自身免疫性疾病的关联。1-5项综合研究报道了甲状腺自身免疫与25-羟基维生素D (25-OHD)之间的关系。2型糖尿病(T2DM)在沙特阿拉伯的患病率很高,高达30%维生素D缺乏(VDD)仍然是一个主要的健康问题近年来,VDD因其高发病率及其与多种慢性疾病发生的关系而受到特别关注。VDD在普通人群中的高患病率表明,VDD在糖尿病等慢性疾病中更为常见。
{"title":"Association of vitamin D status and thyroid function among type 2 diabetic mellitus patients","authors":"K. Aljabri","doi":"10.15406/aowmc.2019.09.00276","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00276","url":null,"abstract":"Vitamin D is an important element for skeletal health and it may also affect extra-skeletal health such as association with autoimmune diseases.1–5 Inclusive studies in have reported an association between thyroid autoimmunity and 25-hydroxyvitamin D (25-OHD).6–8 Type 2 diabetes mellitus (T2DM) prevalence in Saudi Arabia is high, reaching up to 30%.9 Vitamin D deficiency (VDD) remains a major health problem.10 VDD has received special attention lately because of its high incidence and its implication in the genesis of multiple chronic illnesses. The high prevalence of VDD in general population underlines the fact that VDD is more common in chronic diseases like diabetes mellitus.","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85787191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mentholated cigarettes or weight problems, which came first 薄荷烟或体重问题,是最先出现的
Pub Date : 2019-05-09 DOI: 10.15406/aowmc.2019.09.00275
M. Míguez, Calonie M. K. Gray, C. Stanton, Diego Bueno, C. Kahler
Obesity, defined as a body mass index (BMI ≥30), has reached epidemic proportions in the United States and it is one of the nation’s leading public health challenges. Obesity rates for males and females in the U.S. had been similar, however,1–3 more recently just over 40 percent of women are obese, compared to 35 percent of men. These rates are of high concern when compared to the 15 percent of women worldwide. Aggressive tobacco industry advertising have resulted in over 20 million female smokers in the United States.4 For years, the tobacco industry has exploited the belief that smoking is helpful in controlling weight, to influence commencement and continuation of smoking.1-3 Adults do not only use smoking as a method for weight control; adolescents who have dieted or are constantly concerned with weight are also more likely to start smoking.5–7 Notably, these observations were gender and specific, significant among females, but not among males.5–7
肥胖,定义为身体质量指数(BMI≥30),在美国已经达到流行病的程度,它是美国主要的公共卫生挑战之一。在美国,男性和女性的肥胖率一直是相似的,然而,最近女性的肥胖率刚刚超过40%,而男性的肥胖率为35%。与全球15%的女性相比,这些比率令人高度关注。烟草业咄咄逼人的广告使美国有2000多万女性吸烟者。多年来,烟草业利用吸烟有助于控制体重的信念来影响吸烟的开始和继续。1-3成年人不要仅仅把吸烟作为控制体重的方法;节食或经常担心体重的青少年也更有可能开始吸烟。值得注意的是,这些观察结果是性别和特异性的,在女性中很重要,但在男性中没有
{"title":"Mentholated cigarettes or weight problems, which came first","authors":"M. Míguez, Calonie M. K. Gray, C. Stanton, Diego Bueno, C. Kahler","doi":"10.15406/aowmc.2019.09.00275","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00275","url":null,"abstract":"Obesity, defined as a body mass index (BMI ≥30), has reached epidemic proportions in the United States and it is one of the nation’s leading public health challenges. Obesity rates for males and females in the U.S. had been similar, however,1–3 more recently just over 40 percent of women are obese, compared to 35 percent of men. These rates are of high concern when compared to the 15 percent of women worldwide. Aggressive tobacco industry advertising have resulted in over 20 million female smokers in the United States.4 For years, the tobacco industry has exploited the belief that smoking is helpful in controlling weight, to influence commencement and continuation of smoking.1-3 Adults do not only use smoking as a method for weight control; adolescents who have dieted or are constantly concerned with weight are also more likely to start smoking.5–7 Notably, these observations were gender and specific, significant among females, but not among males.5–7","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84244761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of telmisartan and enalapril in patients with diabetic nephropathy 替米沙坦联合依那普利治疗糖尿病肾病疗效观察
Pub Date : 2019-04-16 DOI: 10.15406/aowmc.2019.09.00274
Sharvana Bhava Bs, B SivaSubrahmanyam, Ashrith Reddy Ch, D. Akhil, K. Haripriya, K. Suresh, E. Venkateshwarlu
Diabetes mellitus is a metabolic complex disorder characterised by hyperglycaemia and glucose intolerance as their hallmark due to insulin deficiency or impaired effectiveness of insulin action.1 Diabetic nephropathy is one of the potential micro vascular complications in diabetic patients. It is the leading cause of End stage renal disease (ESRD). Diabetic kidney disease refers to chronic kidney disease (CKD) presumed to be caused by diabetes.2 Diabetic nephropathy is screened for persistent abnormal urine albumin excretion and by decreased glomerular filtration rate (GFR). Albuminuria has been divided into micro albuminuria (urine albumin creatinine ratio (UACR) 30-300 mg/dl) and macro albuminuria (UACR more than 300mg/dl). Serum creatinine derives estimates of GRF and diabetic kidney disease.3
糖尿病是一种代谢复杂疾病,以高血糖和葡萄糖不耐受为特征,是由于胰岛素缺乏或胰岛素作用有效性受损所致糖尿病肾病是糖尿病患者潜在的微血管并发症之一。它是终末期肾病(ESRD)的主要原因。1 .糖尿病肾病是指推定由糖尿病引起的慢性肾脏疾病(CKD)糖尿病肾病筛查持续异常尿白蛋白排泄和降低肾小球滤过率(GFR)。蛋白尿分为微量蛋白尿(尿白蛋白肌酐比值(UACR) 30- 300mg/dl)和巨量蛋白尿(UACR大于300mg/dl)。血清肌酐可用于评估GRF和糖尿病肾病
{"title":"Efficacy of telmisartan and enalapril in patients with diabetic nephropathy","authors":"Sharvana Bhava Bs, B SivaSubrahmanyam, Ashrith Reddy Ch, D. Akhil, K. Haripriya, K. Suresh, E. Venkateshwarlu","doi":"10.15406/aowmc.2019.09.00274","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00274","url":null,"abstract":"Diabetes mellitus is a metabolic complex disorder characterised by hyperglycaemia and glucose intolerance as their hallmark due to insulin deficiency or impaired effectiveness of insulin action.1 Diabetic nephropathy is one of the potential micro vascular complications in diabetic patients. It is the leading cause of End stage renal disease (ESRD). Diabetic kidney disease refers to chronic kidney disease (CKD) presumed to be caused by diabetes.2 Diabetic nephropathy is screened for persistent abnormal urine albumin excretion and by decreased glomerular filtration rate (GFR). Albuminuria has been divided into micro albuminuria (urine albumin creatinine ratio (UACR) 30-300 mg/dl) and macro albuminuria (UACR more than 300mg/dl). Serum creatinine derives estimates of GRF and diabetic kidney disease.3","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73218545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Relationship between dietary intake and prevalence of obesity in children with down’s syndrome 饮食摄入与唐氏综合症儿童肥胖患病率的关系
Pub Date : 2019-04-01 DOI: 10.15406/aowmc.2019.09.00271
Angbeen Chaudhary
Down’s syndrome is a condition that is characterized by mental and growth retardation associated with genetic anomalies, it affects approximately one in 800 live births globally by Aitken & Spencer, whereas the incidence of Down’s syndrome in Pakistan is one in 700 live births by Jamil. There are three types of Down syndrome called Trisomy 21, Translocation and Mosaicism all of which differ in the person’s mental ability but have the same characteristics i.e. short stature, broad facial profile, hyper-flexibility, enlarged tongue and obesity. Children with Down’s syndrome are more likely to suffer from obesity and overweight. According to a study, 50% children suffering from Down’s syndrome are obese or at a risk of developing obesity in the later years of their life by O’Brien. This alarming rate of obesity development in these children is due to a number of causes like genetics, environmental, social and most importantly dietary.1–6
唐氏综合症是一种以与基因异常相关的智力和生长发育迟缓为特征的疾病,根据艾特肯和斯宾塞公司的数据,全球大约每800名活产婴儿中就有1人患有唐氏综合症,而根据贾米尔的数据,巴基斯坦的唐氏综合症发病率为每700名活产婴儿中就有1人患有唐氏综合症。唐氏综合症有三种类型,分别是21三体、易位型和镶嵌型,它们在人的智力上有所不同,但具有相同的特征,即身材矮小、面部轮廓宽阔、高度柔韧性、舌头肥大和肥胖。患有唐氏综合症的儿童更容易肥胖和超重。根据奥布莱恩的一项研究,50%患有唐氏综合症的儿童肥胖或在晚年有肥胖的风险。这些儿童肥胖发展的惊人速度是由许多原因造成的,比如遗传、环境、社会,最重要的是饮食
{"title":"Relationship between dietary intake and prevalence of obesity in children with down’s syndrome","authors":"Angbeen Chaudhary","doi":"10.15406/aowmc.2019.09.00271","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00271","url":null,"abstract":"Down’s syndrome is a condition that is characterized by mental and growth retardation associated with genetic anomalies, it affects approximately one in 800 live births globally by Aitken & Spencer, whereas the incidence of Down’s syndrome in Pakistan is one in 700 live births by Jamil. There are three types of Down syndrome called Trisomy 21, Translocation and Mosaicism all of which differ in the person’s mental ability but have the same characteristics i.e. short stature, broad facial profile, hyper-flexibility, enlarged tongue and obesity. Children with Down’s syndrome are more likely to suffer from obesity and overweight. According to a study, 50% children suffering from Down’s syndrome are obese or at a risk of developing obesity in the later years of their life by O’Brien. This alarming rate of obesity development in these children is due to a number of causes like genetics, environmental, social and most importantly dietary.1–6","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87788986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Obesity: a chronic disease 肥胖是一种慢性疾病
Pub Date : 2019-03-02 DOI: 10.15406/aowmc.2019.09.00272
Katerina A Chremou
The average European has about 5 hours of sedentary work / day. The amount of calories that an employee spends a day in his work has been reduced (since 1960) by 15% due to sedentary work. 60% of Europeans use the car for their daily transport. It is estimated that in 2050 80% of Europeans will live in urban areas. Larger portions: the portion in soft drinks with sugar and snacks has increased up to +100% (1960). We consume an average of 500kcal / day since 1960. 42% of Europeans do no exercise.
欧洲人平均每天坐着工作约5小时。自1960年以来,由于久坐不动,员工每天在工作中消耗的卡路里量减少了15%。60%的欧洲人使用汽车作为日常交通工具。据估计,到2050年,80%的欧洲人将生活在城市地区。更大的份量:含糖软饮料和零食的份量增加到100%(1960年)。自1960年以来,我们平均每天消耗500千卡。42%的欧洲人不锻炼。
{"title":"Obesity: a chronic disease","authors":"Katerina A Chremou","doi":"10.15406/aowmc.2019.09.00272","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00272","url":null,"abstract":"The average European has about 5 hours of sedentary work / day. The amount of calories that an employee spends a day in his work has been reduced (since 1960) by 15% due to sedentary work. 60% of Europeans use the car for their daily transport. It is estimated that in 2050 80% of Europeans will live in urban areas. Larger portions: the portion in soft drinks with sugar and snacks has increased up to +100% (1960). We consume an average of 500kcal / day since 1960. 42% of Europeans do no exercise.","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74625556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Have Probiotics and Synbiotics passed the test of time to be implemented in management of obesity and related metabolic disorders-a comprehensive review 益生菌和合成菌是否通过了时间的考验,可以应用于肥胖和相关代谢紊乱的治疗
Pub Date : 2019-02-28 DOI: 10.15406/aowmc.2019.09.00269
K. Kaur, G. Allahbadia, M. Singh
Obesity continues to be a big public health problem, with its prevalence increasing continuously. As per the WHO it has been estimate that In last 40 years, obesity prevalence almost tripled and in 2016, over 650million people around the world, which included various million infants and children became obese.1 Increased body weight is associated with development of several severe chronic conditions like type 2 diabetes mellitus, (T2DM), cardiovascular disease (CVD), musculoskeletal disorders and different cancers.2 Every year because of overweight/obesity, there are 28million deaths worldwide.2 Further obesity leads to a big medical, social and economic burden.3 We have been trying to find simple answers for treating obesity, medically, the problem remains that gradually most of the previous approved medications for obesity have got removed from the market, in view of different side effects, along with their inability to maintain long term weight loss.4–8 Although interventions like bariatric surgery are the most effective till date for reducing increased weight in people with morbid obesity, it is a very invasive procedure, having risks of unforeseen complications along with needing marked effort in adopting a new lifestyle [reviewed in ref.9 Thus need for looking simpler approaches is there. Symbiosis has been described in nonalcoholic steatohepatitis (NASH),10,11 T2DM, metabolic syndrome,12–15 and obesity,16,17 As far as overweight/obesity, is concerned various studies have demonstrated that the gut micro bio decomposition may be significantly different from lean individuals, the faecal bacteria may exert a key role in modulating energy metabolism with modifications of gut microbiotacomposition might be associated with decreases In body mass index (BMI)16,17 Reviewed in ref. 5,18,19 In view of this manipulation of gut microbiota composition using probiotics has been considered a possible way for preventing and treating obesity. The word probiotic comes from the Greek word, which means ‘’for life’. Despite ’lot of change in definitions, currently the definition recognized by Food and Agricultural Organization of the United Nations (FAO) and world health organization (WHO) working group experts is that probiotics are live strains of strictly selected microorganisms, which once administered in adequate amounts, give a health benefit to the host.20 This definition was accepted by the International Scientific Association of Probiotics and Probiotics (ISAPP) in 2013.21 Though dead bacteria and their components can also show probiotic properties. Most commonly used bacterial strains are Bifidobacteria and Lactobacillus that exhibit probiotic properties and get included in many functional foods and dietary supplements.22 Main mechanisms of actions of probiotics are improvement of the gut barrier function ,increasing competitive adherence to the mucosa and epithelium, modification of gut microbiota, along with regulation of the gut associated lymphoid
肥胖仍然是一个重大的公共卫生问题,其患病率不断上升。据世界卫生组织估计,在过去的40年里,肥胖患病率几乎增加了两倍,2016年,全球有超过6.5亿人肥胖,其中包括数百万婴儿和儿童体重增加与几种严重慢性疾病的发展有关,如2型糖尿病(T2DM)、心血管疾病(CVD)、肌肉骨骼疾病和不同癌症由于超重/肥胖,全世界每年有2800万人死亡进一步的肥胖会导致巨大的医疗、社会和经济负担我们一直在试图找到治疗肥胖的简单答案,但从医学上讲,问题仍然存在,因为有不同的副作用,而且它们无法保持长期的减肥效果,大多数以前批准的治疗肥胖的药物已经逐渐退出了市场。尽管像减肥手术这样的干预措施是迄今为止最有效的减轻病态肥胖患者体重的方法,但这是一个非常具有侵入性的过程,有不可预见的并发症的风险,而且需要付出很大的努力来适应新的生活方式[参考文献9],因此需要寻找更简单的方法。非酒精性脂肪性肝炎(NASH)、2型糖尿病(T2DM)、代谢综合征(metabolic syndrome)、12-15和肥胖(obesity)中都有共生现象,就超重/肥胖而言,各种研究表明,肠道微生物分解可能与瘦人有显著不同。粪便细菌可能在调节能量代谢中发挥关键作用,肠道微生物组成的改变可能与体重指数(BMI)的降低有关16,17。鉴于此,使用益生菌控制肠道微生物组成已被认为是预防和治疗肥胖的可能途径。益生菌这个词来自希腊语,意思是“生命”。尽管定义有很多变化,但目前联合国粮食及农业组织(FAO)和世界卫生组织(WHO)工作组专家认可的定义是,益生菌是严格挑选的微生物的活菌株,一旦给予足够的量,就会对宿主的健康有益这一定义在2013年被国际益生菌和益生菌科学协会(ISAPP)所接受。21尽管死菌及其成分也可以表现出益生菌的特性。22 .最常用的菌株是双歧杆菌和乳杆菌,它们具有益生菌的特性,被包括在许多功能性食品和膳食补充剂中益生菌的作用机制主要有:改善肠道屏障功能,增加对粘膜和上皮的竞争性粘附,改变肠道菌群,因此,益生菌通过肠道细胞模式识别受体(如toll样受体和核苷酸结合寡聚结构域含蛋白样受体)与宿主进行交流,这些受体调节重要的生命信号通路,如核因子κB (NFκB)和丝裂原活化蛋白激酶,以增加或抑制下游通路的激活或影响。21,23 - 26益生菌是一种非活的食物成分,它对宿主的健康有益,与微生物群的调节有关,这可能是一种纤维,但并非所有的纤维都是益生菌。益生菌和益生菌一起使用通常被称为合成菌,如果净健康效益是协同的27益生菌和合成菌以多种多样的形式服用,如酸奶和其他发酵牛奶,奶酪和各种发酵食品,除了预防和治疗不同的胃肠道功能障碍和其他疾病,如过敏然而,益生菌如何改变肠道生态的实际影响仍然存在争议,考虑到各种混淆因素,如微生物菌株的差异,活细胞的浓度和产品配方。Yao和Kim表明,益生菌和益生菌通过改变肠道菌群、调节胰岛素信号以及降低胆固醇来影响2型糖尿病(T2DM)和心血管疾病(CVD)因此,
{"title":"Have Probiotics and Synbiotics passed the test of time to be implemented in management of obesity and related metabolic disorders-a comprehensive review","authors":"K. Kaur, G. Allahbadia, M. Singh","doi":"10.15406/aowmc.2019.09.00269","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00269","url":null,"abstract":"Obesity continues to be a big public health problem, with its prevalence increasing continuously. As per the WHO it has been estimate that In last 40 years, obesity prevalence almost tripled and in 2016, over 650million people around the world, which included various million infants and children became obese.1 Increased body weight is associated with development of several severe chronic conditions like type 2 diabetes mellitus, (T2DM), cardiovascular disease (CVD), musculoskeletal disorders and different cancers.2 Every year because of overweight/obesity, there are 28million deaths worldwide.2 Further obesity leads to a big medical, social and economic burden.3 We have been trying to find simple answers for treating obesity, medically, the problem remains that gradually most of the previous approved medications for obesity have got removed from the market, in view of different side effects, along with their inability to maintain long term weight loss.4–8 Although interventions like bariatric surgery are the most effective till date for reducing increased weight in people with morbid obesity, it is a very invasive procedure, having risks of unforeseen complications along with needing marked effort in adopting a new lifestyle [reviewed in ref.9 Thus need for looking simpler approaches is there. Symbiosis has been described in nonalcoholic steatohepatitis (NASH),10,11 T2DM, metabolic syndrome,12–15 and obesity,16,17 As far as overweight/obesity, is concerned various studies have demonstrated that the gut micro bio decomposition may be significantly different from lean individuals, the faecal bacteria may exert a key role in modulating energy metabolism with modifications of gut microbiotacomposition might be associated with decreases In body mass index (BMI)16,17 Reviewed in ref. 5,18,19 In view of this manipulation of gut microbiota composition using probiotics has been considered a possible way for preventing and treating obesity. The word probiotic comes from the Greek word, which means ‘’for life’. Despite ’lot of change in definitions, currently the definition recognized by Food and Agricultural Organization of the United Nations (FAO) and world health organization (WHO) working group experts is that probiotics are live strains of strictly selected microorganisms, which once administered in adequate amounts, give a health benefit to the host.20 This definition was accepted by the International Scientific Association of Probiotics and Probiotics (ISAPP) in 2013.21 Though dead bacteria and their components can also show probiotic properties. Most commonly used bacterial strains are Bifidobacteria and Lactobacillus that exhibit probiotic properties and get included in many functional foods and dietary supplements.22 Main mechanisms of actions of probiotics are improvement of the gut barrier function ,increasing competitive adherence to the mucosa and epithelium, modification of gut microbiota, along with regulation of the gut associated lymphoid ","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75889851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Weight reduction program with continuous psychological support in obese patients 肥胖患者持续心理支持的减重计划
Pub Date : 2019-02-28 DOI: 10.15406/aowmc.2019.09.00268
H. Bando, Toshimi Nakamura, A. Narita, M. Dobashi, T. Kawashima
Obesity has been recently one of the important public health problems, with the increasing tendency of Body Mass Index (BMI) in the world.1 The prevalence of obesity or overweight has been twice of that of 1980 and about one third of population in the world is supposed to be obese or overweight.2 The cause of the obesity has been multi-factorials, and the prevention of the obesity includes environmental interventions and various lifestyle changes. For the medical management of obesity and overweight, there was a standard guideline. It was the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines and The Obesity Society (AHA/ACC/TOS) in 2013, and it showed various available evidence to medical practice.3 It has been often found that obese people had succeeded weight reduction, but could not maintain the weight easily. From previous reports, the important factors have been the correlations among lifestyle, dietary and psychosocial situations.4 Then, further research would be expected concerning the behavioral and clinical characteristics of maintaining satisfactory weight reduction. On the other hand, there was an ‘adult disease’ a few decades ago in Japan. After that, it was changed to ‘life style related disease’ because their geneses are probably due to inadequate lifestyle situation.5 It was proposed by Dr. Shigeaki Hinohara who was the President Emeritus of St. Luke International Hospital in Tokyo associated with the philosophy ‘Hinohara-ism’.6 Consecutively, the medical term ‘metabolic syndrome’ has been prevalent including obesity, diabetes mellitus, hypertension and hyperlipidemia. There is a possibility that hyperuricemia and gout has been also added as another factors in the future.7 As to the treatment of metabolic syndrome, the basic therapy would be the control of the body weight. Consequently, the weight reduction should be tried at first for the treatment of metabolic syndrome and obesity prior to starting various medicine.8 The actual method for weight reduction includes both diet therapy and exercise therapy. For diet therapy, there was a standard method, which was calorie restriction (CR). After that, low carbohydrate diet (LCD) has been introduced in Western countries. In succession, authors and colleagues had started LCD in Japan9 and developed LCD through medical practice, medical society, workshop and textbooks.10 We have proposed three patterns of LCD meal including super-LCD, standard-LCD and petite-LCD, which can be applied in various clinical situation.11 Among our clinical research, we have treated lots of patients with obesity in weight reduction program. During the program, they were given medical, nutritional and psychological supports by medical staffs including registered dietitian nutritionists (RDNs). Their managements and advises were based on several medical and psychological supports.12 The detail of the program was described and discussed in this report.
近年来,随着世界各国身体质量指数(BMI)呈上升趋势,肥胖已成为重要的公共卫生问题之一肥胖或超重的流行率是1980年的两倍,世界上大约三分之一的人口被认为是肥胖或超重肥胖的成因是多方面的,肥胖的预防包括环境干预和各种生活方式的改变。对于肥胖和超重的医疗管理,有一个标准的指导方针。它是2013年美国心脏病学会/美国心脏协会实践指南工作组和肥胖协会(AHA/ACC/TOS),它展示了各种现有的医学实践证据人们经常发现,肥胖的人减肥成功,但不能轻易保持体重。从以前的报告来看,重要的因素是生活方式、饮食和社会心理状况之间的相关性在此基础上,进一步研究维持满意减肥效果的行为和临床特征。另一方面,几十年前在日本有一种“成人病”。之后,它被改为“生活方式相关疾病”,因为他们的基因可能是由于不适当的生活方式造成的它是由东京圣路加国际医院名誉院长日原茂明博士提出的,他的理念是“日原主义”随后,医学术语“代谢综合征”也开始流行,包括肥胖、糖尿病、高血压和高脂血症。高尿酸血症和痛风也有可能成为未来的另一个因素对于代谢综合征的治疗,基本的治疗方法是控制体重。因此,在开始使用各种药物之前,应先尝试减肥以治疗代谢综合征和肥胖实际的减肥方法包括饮食疗法和运动疗法。对于饮食疗法,有一个标准的方法,即卡路里限制(CR)。此后,低碳水化合物饮食(LCD)被引入西方国家。随后,作者和同事们在日本启动了LCD,并通过医疗实践、医学协会、研讨会和教科书发展了LCD我们提出了超液晶、标准液晶和小液晶三种液晶模式,可应用于各种临床情况在我们的临床研究中,我们在减肥项目中治疗了许多肥胖患者。在项目期间,他们得到了包括注册营养师(rdn)在内的医务人员的医疗、营养和心理支持。他们的管理和咨询以若干医疗和心理支持为基础本报告对该计划的细节进行了描述和讨论。
{"title":"Weight reduction program with continuous psychological support in obese patients","authors":"H. Bando, Toshimi Nakamura, A. Narita, M. Dobashi, T. Kawashima","doi":"10.15406/aowmc.2019.09.00268","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00268","url":null,"abstract":"Obesity has been recently one of the important public health problems, with the increasing tendency of Body Mass Index (BMI) in the world.1 The prevalence of obesity or overweight has been twice of that of 1980 and about one third of population in the world is supposed to be obese or overweight.2 The cause of the obesity has been multi-factorials, and the prevention of the obesity includes environmental interventions and various lifestyle changes. For the medical management of obesity and overweight, there was a standard guideline. It was the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines and The Obesity Society (AHA/ACC/TOS) in 2013, and it showed various available evidence to medical practice.3 It has been often found that obese people had succeeded weight reduction, but could not maintain the weight easily. From previous reports, the important factors have been the correlations among lifestyle, dietary and psychosocial situations.4 Then, further research would be expected concerning the behavioral and clinical characteristics of maintaining satisfactory weight reduction. On the other hand, there was an ‘adult disease’ a few decades ago in Japan. After that, it was changed to ‘life style related disease’ because their geneses are probably due to inadequate lifestyle situation.5 It was proposed by Dr. Shigeaki Hinohara who was the President Emeritus of St. Luke International Hospital in Tokyo associated with the philosophy ‘Hinohara-ism’.6 Consecutively, the medical term ‘metabolic syndrome’ has been prevalent including obesity, diabetes mellitus, hypertension and hyperlipidemia. There is a possibility that hyperuricemia and gout has been also added as another factors in the future.7 As to the treatment of metabolic syndrome, the basic therapy would be the control of the body weight. Consequently, the weight reduction should be tried at first for the treatment of metabolic syndrome and obesity prior to starting various medicine.8 The actual method for weight reduction includes both diet therapy and exercise therapy. For diet therapy, there was a standard method, which was calorie restriction (CR). After that, low carbohydrate diet (LCD) has been introduced in Western countries. In succession, authors and colleagues had started LCD in Japan9 and developed LCD through medical practice, medical society, workshop and textbooks.10 We have proposed three patterns of LCD meal including super-LCD, standard-LCD and petite-LCD, which can be applied in various clinical situation.11 Among our clinical research, we have treated lots of patients with obesity in weight reduction program. During the program, they were given medical, nutritional and psychological supports by medical staffs including registered dietitian nutritionists (RDNs). Their managements and advises were based on several medical and psychological supports.12 The detail of the program was described and discussed in this report.","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84077197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consistent weight loss linked to higher meal frequency 持续的减肥与更高的进餐频率有关
Pub Date : 2019-02-26 DOI: 10.15406/aowmc.2019.09.00267
Peregrin-Alvarez Jm
Obesity has been a global topic of concern for a long time as it is directly linked to human disease, causing more than 3.4 million deaths all around the word.1–3 To avoid this serious health issue, successful weight management programs should consider the required timing for feedback signals originating in adipose tissue to influence the brain centres that control eating behavior and activity (metabolic and motor),the fundamental of the “Lipostat theory”,4 which has been demonstrated for the very first time in humans in our previous study.5 This theory refers to the control of long term appetite, responsible for the control of body weight. As fat deposits accumulate, satiety signals are sent to the hypothalamus in response in an attempt to suppress the feeling of hunger and maintain a constant body weight. The study showed that HA was more efficient than simple BMI measurements, and the subject under study, originally obese, able to successfully reach and maintain an HA category (IW) over the years. New concepts and ideas were raised by that study, setting up the bases for further experimental validations. Thus, continuing with that study, the purpose of this case report is to present and discuss our selfexperimental research on meal frequency over a long period of time with respect to changes in body weight.
长期以来,肥胖一直是一个全球关注的话题,因为它与人类疾病直接相关,导致全球340多万人死亡。1-3为了避免这种严重的健康问题,成功的体重管理计划应该考虑到产生于脂肪组织的反馈信号所需的时间,以影响控制饮食行为和活动(代谢和运动)的大脑中心,这是“脂肪理论”的基础,4在我们之前的研究中首次在人类身上得到证实这个理论指的是长期控制食欲,负责控制体重。随着脂肪堆积,饱腹感信号被发送到下丘脑,试图抑制饥饿感并保持恒定的体重。研究表明,HA比简单的BMI测量更有效,研究对象,原本肥胖,能够成功地达到并保持HA类别(IW)多年。该研究提出了新的概念和想法,为进一步的实验验证奠定了基础。因此,继续这项研究,本病例报告的目的是展示和讨论我们长期以来进餐频率与体重变化之间的自我实验研究。
{"title":"Consistent weight loss linked to higher meal frequency","authors":"Peregrin-Alvarez Jm","doi":"10.15406/aowmc.2019.09.00267","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00267","url":null,"abstract":"Obesity has been a global topic of concern for a long time as it is directly linked to human disease, causing more than 3.4 million deaths all around the word.1–3 To avoid this serious health issue, successful weight management programs should consider the required timing for feedback signals originating in adipose tissue to influence the brain centres that control eating behavior and activity (metabolic and motor),the fundamental of the “Lipostat theory”,4 which has been demonstrated for the very first time in humans in our previous study.5 This theory refers to the control of long term appetite, responsible for the control of body weight. As fat deposits accumulate, satiety signals are sent to the hypothalamus in response in an attempt to suppress the feeling of hunger and maintain a constant body weight. The study showed that HA was more efficient than simple BMI measurements, and the subject under study, originally obese, able to successfully reach and maintain an HA category (IW) over the years. New concepts and ideas were raised by that study, setting up the bases for further experimental validations. Thus, continuing with that study, the purpose of this case report is to present and discuss our selfexperimental research on meal frequency over a long period of time with respect to changes in body weight.","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85571350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Advances in obesity, weight management & control
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1