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Effects of aging, phenotype and carbohydrate feeding on caloric efficiency and adiposity in the LA/Ntul//-cp (corpulent) rat 衰老、表型和碳水化合物饲喂对LA/Ntul//-cp(肥胖)大鼠热效率和肥胖的影响
Pub Date : 2021-02-09 DOI: 10.15406/AOWMC.2021.11.00329
O. Tulp
Obesity develops in the obese phenotype of the LA/Ntul//-cp (corpulent) specific pathogen-free rat strain by 5 to 6 weeks of age. Groups [n=12 -20 rats/phenotype] of female congenic lean and obese LA/Ntul//-cp (corpulent) rats were fed ad libitum standardized Purina diets for 4, 14, or 24 months or the same diet plus a 16% (w/v) sucrose solution supplement from 12 weeks of age, and measures of body weight, caloric intake, and caloric efficiency (CE) determined at each age group. Body weights of lean animals remained similar at all ages studied, while body weights of obese phenotype were significantly greater than their lean littermates at each age studied. The sucrose supplement was without significant effect on final body weights in the lean phenotypes at all ages studied (p=n.s.) but were associated with greater body weights at ages 4, 14 and 24 months of age in the obese phenotype (p=<0.05). CE was determined as the ratio of kcal/gram of body weight per day remained relatively constant in lean animals throughout the age range, but CE was more efficient in the obese phenotype at all ages studied and became progressively more efficient with the sucrose supplement feeding with increasing age. The results of this study indicate that CE is associated with the predisposition for the development of obesity in the obese phenotype of this strain and likely implicates multiple metabolic factors that contribute to a greater efficiency of energy utilization and or energy conservation in the obese than in the lean phenotype of this strain, and the metabolic impact of added sucrose was associated with an additive impact on the CE of weight gain and adiposity in the obese phenotype of this congenic rodent strain
LA/Ntul//-cp(肥胖)特异性无病原体大鼠品系在5至6周龄时出现肥胖表型。雌性先天性瘦肉和肥胖LA/Ntul//-cp(肥胖)大鼠组[n=12 -20只大鼠/表型]在4、14或24个月时随意饲喂标准Purina日粮,或从12周龄开始饲喂同样的日粮加16% (w/v)蔗糖溶液,并测定每个年龄组的体重、热量摄入和热量效率(CE)。瘦仔鼠的体重在所有研究年龄都保持相似,而肥胖表型的体重在每个研究年龄都明显大于瘦仔鼠。在所有年龄的研究中,蔗糖补充对瘦型的最终体重没有显著影响(p= 0.05),但与肥胖型的4、14和24月龄的较大体重相关(p=<0.05)。在整个年龄范围内,瘦肉动物每天卡路里/克体重的比率保持相对恒定,因此确定了CE,但CE在所有年龄的肥胖表型中都更有效,并且随着年龄的增长,补充蔗糖的效率逐渐提高。本研究结果表明,CE与该菌株肥胖表型中肥胖发展的易感性相关,并且可能涉及多种代谢因素,这些代谢因素有助于该菌株中肥胖的能量利用和/或能量节约效率高于瘦表型。添加蔗糖的代谢影响与这种遗传啮齿类动物肥胖表型中体重增加和肥胖的附加影响相关
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引用次数: 6
Insulin as a predictor of diabetes type 2: a new medical hypothesis 胰岛素作为2型糖尿病的预测因子:一个新的医学假设
Pub Date : 2021-01-05 DOI: 10.15406/AOWMC.2021.11.00328
Ahed J. Alkhatib, A. Sindiani, E. Alshdaifat
Since the discovery of diabetes, it is about insulin production, or function. In this study, we may introduce a controversial concept. Insulin as a predictor of diabetes, in other words, insulin can cause diabetes type 2. We think that this could serve as a new medical hypothesis. To examine this hypothesis, we analyzed dataset posted in Kaggle from India. The dataset included 763 female patients of whom 497 had no diabetes, and 266 with type 2 diabetes. We used routine statistical analysis and neural network analysis. The results showed that insulin level increases as the diabetes is progressed, and its relative contribution to diabetes was estimated as 28.4%. Taken together, insulin measurement is recommended to be considered in the management of diabetes.
自从发现糖尿病以来,它就是关于胰岛素的产生,或者说是功能。在本研究中,我们可能会引入一个有争议的概念。胰岛素是糖尿病的预测因子,换句话说,胰岛素会导致2型糖尿病。我们认为这可以作为一种新的医学假设。为了检验这一假设,我们分析了印度Kaggle上发布的数据集。该数据集包括763名女性患者,其中497名没有糖尿病,266名患有2型糖尿病。我们使用常规统计分析和神经网络分析。结果表明,胰岛素水平随着糖尿病的进展而升高,其对糖尿病的相对贡献估计为28.4%。综上所述,建议在糖尿病管理中考虑胰岛素测量。
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引用次数: 0
The impact of a 6 week walking intervention on an obese population in relation to walking distance, waist to height ratio and body mass index 6周步行干预对肥胖人群步行距离、腰高比和体重指数的影响
Pub Date : 2020-12-11 DOI: 10.15406/AOWMC.2020.10.00326
Claire Mills, Harry Wellington
Obesity is a health condition, often resulting from an imbalance between physical activity and calorie intake and while invasive and intense interventions may be necessary for some obese individuals (OI), changes in activity and lifestyle over long periods of time are arguably the safest, most sustainable solution. High Intensity Interval Training (HIIT) has been widely observed to increase rapid fat oxidation in obese populations (OPs), it conversely increases health risks for OIs who often have limited cardiovascular fitness, increased joint loading and high blood pressure. However, submaximal aerobic exercise, such as walking, can be used as an initial intervention for OI who lead sedentary lifestyles, to reduce weight and increase aerobic capacity in an arguably safer way. Therefore, the aim of this study was to investigate the effect that a submaximal walking intervention has on anthropometric measures in an OP
肥胖是一种健康状况,通常是由身体活动和卡路里摄入之间的不平衡造成的,虽然对一些肥胖者(OI)可能需要侵入性和高强度的干预,但长期改变活动和生活方式可以说是最安全、最可持续的解决方案。高强度间歇训练(HIIT)已被广泛观察到可以增加肥胖人群(OPs)的快速脂肪氧化,相反,它会增加心血管健康有限、关节负荷增加和高血压的oi的健康风险。然而,对于久坐不动的成骨不全患者,步行等次最大有氧运动可作为初始干预措施,以更安全的方式减轻体重并增加有氧能力。因此,本研究的目的是研究亚最大步行干预对OP患者人体测量的影响
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引用次数: 0
A rare complication of laparoscopic adjustable gastric band: acute large bowel obstruction 腹腔镜可调节胃束带的罕见并发症:急性大肠阻塞
Pub Date : 2020-12-09 DOI: 10.15406/aowmc.2020.10.00325
A. Menon, Lisa Pedevillano, Melissa L Gott, Timothy S Pilla, G. Slotman
With many thousands patients carrying laparoscopic adjustable gastric band (LAGB), long-term complications can appear emergently to any surgeon. We present a 64 year-old male who underwent placement of a laparoscopic adjustable gastric band (LAGB) years prior presented to the emergency department with concerning signs of an acute abdomen. Upon imaging review a large bowel obstruction at the level of the sigmoid colon, with ischemic changes, was discovered, caused by the patient’s LAGB catheter. The patient was taken emergently for an exploratory laparotomy during which the LAGB catheter was removed, resulting in restored bowel perfusion. Bowel obstructions are infrequent complications of LAGB. However most commonly they are limited to the small bowel. LAGB catheters resulting in large bowel obstructions are an extremely rare finding. Our review of the literature indicates that this is the first reported cause of a sigmoid obstruction caused by a LAGB. This case brings into view potential complications LAGB that can confront not only bariatric surgeons, but general and acute care surgeons as well. This report illustrates LAGB danger to the colon, and suggests how to manage, perhaps leading to early, life-saving intervention
成千上万的患者携带腹腔镜可调节胃束带(LAGB),任何外科医生都可能出现长期并发症。我们提出一个64岁的男性谁接受放置腹腔镜可调节胃带(LAGB)几年前提出了急诊科有关急腹症的迹象。影像学检查发现乙状结肠水平大肠梗阻,伴缺血性改变,由患者的LAGB导管引起。患者被紧急送往剖腹探查术,在探查术中取出了LAGB导管,恢复了肠道灌注。肠梗阻是LAGB的罕见并发症。然而,最常见的是它们仅限于小肠。LAGB导管导致大肠阻塞是一种极其罕见的发现。我们对文献的回顾表明,这是首次报道的由LAGB引起的乙状结肠梗阻的原因。这个病例让我们看到了潜在的LAGB并发症,它不仅可以面对减肥外科医生,也可以面对普通和急性护理外科医生。该报告说明了LAGB对结肠的危险,并建议如何管理,可能导致早期的挽救生命的干预
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引用次数: 0
Association between obesity, dyslipidemia and insulin resistance with suspected fatty liver disease in Greek children with excess weight 希腊超重儿童肥胖、血脂异常和胰岛素抵抗与疑似脂肪肝的关系
Pub Date : 2020-11-25 DOI: 10.15406/aowmc.2020.10.00324
E. Dikaiakou, E. Vlachopapadopoulou, A. Fotiadou, F. Athanasouli, M. Kafetzi, A. Fotinou, S. Michalacos
Objective: This study investigates the association between dyslipidemia and fatty liver disease with body mass index (BMI), waist-to-height ratio (WHtR), waist circumference (WC) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in children and adolescents with overweight or obesity. Methods: Data from 299 children with overweight or obesity (48% boys) with mean age 9.23±2.5 years were analyzed. Alanine aminotransferase (ALT) >25.8 U/L (boys) and >22.1 U/L (girls), was defined as abnormal. Student’s t-tests were computed for the comparison of mean values. Chi-square tests were used for the comparison of proportions. Results: Proportions of children with dyslipidemia and suspected nonalcoholic fatty liver disease (NAFLD) were 23.4% and 31.4% respectively. The percentage of children with NAFLD was 28.3% in those without dyslipidemia and 45% in those with dyslipidemia (p=0.015). BMI, WC and WHtR were not different between children with and without dyslipidemia. BMI was significantly higher in those with NAFLD (p=0.019). A stratified by gender analysis, showed that BMI, WC and WHtR were significantly higher in boys with NAFLD (p=0.009, 0.037, 0.049 respectively). WHtR≥0.5 and ΗΟΜΑ-IR≥3 were not significantly associated with the presence of dyslipidemia (p>0.999, 0.549 respectively), however ΗΟΜΑ-IR ≥3 was more frequent in children with NAFLD (p=0.011). A stratified by gender analysis, showed that the aforementioned association was evident only in boys (p=0.027). Conclusion: The severity of obesity and male gender are clinical indicators of increased risk of dyslipidemia and NAFLD among obese children and adolescents.
目的:探讨超重或肥胖儿童和青少年体重指数(BMI)、腰高比(WHtR)、腰围(WC)和胰岛素抵抗稳态模型评估(HOMA-IR)与血脂异常和脂肪肝的关系。方法:分析299例超重或肥胖儿童的资料,其中男孩占48%,平均年龄9.23±2.5岁。丙氨酸转氨酶(ALT) >25.8 U/L(男生)、>22.1 U/L(女生)为异常。计算学生t检验来比较平均值。比例比较采用卡方检验。结果:血脂异常和疑似非酒精性脂肪肝(NAFLD)患儿比例分别为23.4%和31.4%。无血脂异常组NAFLD患儿占28.3%,有血脂异常组占45% (p=0.015)。血脂异常患儿BMI、WC、WHtR差异无统计学意义。NAFLD组BMI显著增高(p=0.019)。性别分层分析显示,NAFLD男性患者BMI、WC、WHtR均显著增高(p分别为0.009、0.037、0.049)。WHtR≥0.5和ΗΟΜΑ-IR≥3与血脂异常的存在无显著相关性(p分别>0.999和0.549),而ΗΟΜΑ-IR≥3在NAFLD患儿中更为常见(p=0.011)。性别分层分析显示,上述关联仅在男孩中明显(p=0.027)。结论:肥胖严重程度和男性性别是肥胖儿童青少年血脂异常和NAFLD风险增加的临床指标。
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引用次数: 0
The use of Ammi visnaga in the treatment of prediabetes and weight loss: the antioxidant impacts in diabetes treatment as a new medical hypothesis 在糖尿病前期治疗和减肥中的应用:作为一种新的医学假说的抗氧化作用
Pub Date : 2020-11-09 DOI: 10.15406/aowmc.2020.10.00323
Ahed J. Alkhatib
Introduction: Prediabetes status is considered as an important feature in either controlling the development or progression of diabetes. It may pass unnoticed because the symptoms of diabetes are usually not well established. Study objectives: The main objectives of the present study were to explore the efficacy of using Ammi visnagain treating pre-diabetic cases and weight losing. Methods and subjects: A prospective study was conducted to investigate the impact of using Ammi visnaga treatment of pre-diabetes and weight control. The study included 5 patients with pre-diabetes (glucose level was 128±32mg/dl). The age of patients was 42±18.5years. The study included 3 males and 2 females. In general, patients were overweight according to body mass index level was 28±7.8kg/m2. The patients used the aqueous extract of Ammi visnaga for two months (200 ml daily). Results: At the end of the experiment, the glucose level was significantly reduced (p<0.05)to the level of 88±12.5mg/dl. There was also a significant reduction in the level of BMI from 28±7.8kg/m2 to 22±6.4kg/m2(p<0.05). Conclusion: The results of the present study showed that Ammi visnaga has the therapeutic potential to control the progression of complete episodes of diabetes by controlling the pre-diabetic status
前驱糖尿病状态被认为是控制糖尿病发生或进展的重要特征。它可能被忽视,因为糖尿病的症状通常不太明确。研究目的:本研究的主要目的是探讨阿米维尼复治疗糖尿病前期患者和减肥的疗效。方法与对象:采用前瞻性研究方法,探讨阿米果治疗糖尿病前期及体重控制的影响。本研究纳入5例糖尿病前期患者(血糖水平为128±32mg/dl)。患者年龄42±18.5岁。该研究包括3名男性和2名女性。总体而言,患者体重指数为28±7.8kg/m2。患者连续用药2个月(每日200毫升)。结果:实验结束时,血糖水平显著降低(p<0.05),降至88±12.5mg/dl。BMI由28±7.8kg/m2降至22±6.4kg/m2(p<0.05)。结论:本研究结果表明,蜜果具有通过控制糖尿病前期状态来控制糖尿病完全发作的治疗潜力
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引用次数: 0
Reversing type 2 diabetes: journal review and a case study 逆转2型糖尿病:期刊综述和案例研究
Pub Date : 2020-10-30 DOI: 10.15406/AOWMC.2020.10.00322
Ruchika Singh
Type 2 diabetes (T2D) has for quite some time been recognized as a serious interminable malady dependent on conventional methods for treatment. Exploration currently exists that proposes reversal is conceivable through different implies that have as of late been grasped in the rules. This account audit looks at the proof for T2D reversal utilizing every one of the three strategies, including points of interest and constraints for each. Techniques: A research was performed, and an aggregate of unique articles containing data relating to diabetes reversal or abatement were incorporated. Results: Evidence exists that T2D reversal is attainable utilizing bariatric medical procedure, low-calorie nutrient dense and moderate protein diet (LCNP), or starch limitation (LC). Bariatric medical procedure has been suggested for the therapy of T2D since 2016 by a global diabetes agreement gathering. Both the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) presently suggest a LC eating example and backing the momentary utilization of LCNP for weight reduction. Nonetheless, just T2D treatment, not reversal, is talked about in their rules. End: Given the condition of proof for T2D reversal, medical services suppliers should be taught on reversal choices so they can effectively take part in guiding patients who may want this way to deal with their sickness
2型糖尿病(T2D)很长一段时间以来一直被认为是一种依赖于传统治疗方法的严重的慢性疾病。目前存在的探索表明,通过最近在规则中掌握的不同暗示,可以想象反转。此帐户审计使用三种策略中的每一种来查看T2D反转的证明,包括每个策略的兴趣点和约束。技术:进行了一项研究,并纳入了包含与糖尿病逆转或减轻相关数据的独特文章的集合。结果:有证据表明,通过减肥医疗程序、低热量营养密集和中等蛋白质饮食(LCNP)或淀粉限制(LC)可以实现T2D逆转。自2016年以来,全球糖尿病协议会议已建议将减肥医疗程序用于治疗T2D。美国糖尿病协会(ADA)和欧洲糖尿病研究协会(EASD)目前都提出了一个LC饮食的例子,并支持LCNP的短暂使用来减轻体重。尽管如此,在他们的规则中只讨论T2D治疗,而不是逆转。结束:鉴于T2D逆转的证明条件,应向医疗服务提供者传授逆转选择,以便他们能够有效地参与指导可能希望以这种方式处理疾病的患者
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引用次数: 0
Energy imbalance: obesity, associated comorbidities, prevention, management and public health implications 能量失衡:肥胖、相关合并症、预防、管理和公共卫生影响
Pub Date : 2020-10-29 DOI: 10.15406/AOWMC.2020.10.00321
S. Jehan, F. Zizi, S. Pandi‑Perumal, Samy I McFarlane, G. Jean-Louis, Alyson K. Myers
The prevalence of obesity has been continually increasing, as have its associated comorbidities and health care costs. Effective management of obesity and early intervention measures are necessary to overcome this global issue. The responsibility for preventing and managing this global epidemic does not lie solely on an individual, but also on the entire health care system. Policy makers—nationally and globally—must play their roles to solve the issue. In this review article, we examine methods of controlling and managing obesity through interventions, such as a low caloric diet, physical exercise, pharmacological guidance, and bariatric surgical procedures. While health care professionals should educate patients about all available treatment options for severe obesity, bariatric surgical procedures have increased in popularity and are considered very beneficial with outcomes fruitful in managing severe obesity.
肥胖的患病率一直在持续上升,其相关的合并症和医疗保健费用也在不断增加。有效的肥胖管理和早期干预措施是克服这一全球性问题的必要条件。预防和管理这一全球流行病的责任不仅在于个人,还在于整个卫生保健系统。国家和全球的政策制定者必须发挥他们的作用来解决这个问题。在这篇综述文章中,我们研究了通过干预来控制和管理肥胖的方法,如低热量饮食、体育锻炼、药物指导和减肥外科手术。虽然卫生保健专业人员应该教育患者关于严重肥胖的所有可用的治疗选择,但减肥外科手术已经越来越受欢迎,并且被认为对治疗严重肥胖非常有益,结果也很有成效。
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引用次数: 15
Coronavirus & diet: all about boosting immunity 冠状病毒和饮食:都是为了提高免疫力
Pub Date : 2020-10-21 DOI: 10.15406/AOWMC.2020.10.00320
M. Khan
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引用次数: 0
An evaluation of basic food science and main food biotechnology processes products from point of nutrition and obesity 从营养和肥胖的角度评价基础食品科学和主要食品生物技术加工产品
Pub Date : 2020-09-03 DOI: 10.15406/AOWMC.2020.10.00318
Necla Cagarirmak
Food biotechnology comprise sorts of scientific disciplines including food chemistry, biochemistry, molecular biology, microbiology, bioreactors, fermentation process, nutrition and food quality assurance. In the Daily diet, fermented food and drinks have and special importance because of their functional properties and biochemical compounds. Food biotechnology products have great importance from point of nutrition and obesity. Alcohol consumption must be reduced because of high calorie intake and harmful effect to some organs such as brain, liver and also cause social problems when consumed excessive amount.In Turkish traditional fermented foods such as yogurt, kefir and kımız, boza, ty and tarhana and special pickles etc., have various functional properties and biochemical compounds that have beneficial effect to organism. They contain lactic acid bacteria, probiotics, B complex vitamins, nutritive minerals, and some specific compounds which can prevent to development of cancer and tumors, cardiovascular diseases and cholesterol reducing effect. Food biotechnology also includes Genetically Modified Organism (GMO). Studies are evaluated in food biotechnology too. On the other hand, the another significant and common fermented product types are beer, wine, wine agar, even distilled alcohol drinks those produced ethyl alcohol from carbohydrates sources e.g. gape fig, barley, wheat, rice or any carbohydrate sources. Food biotechnology can be evaluated in basic food science and food biotechnology process. The mentioned topics were reviewed in detail.
食品生物技术包括食品化学、生物化学、分子生物学、微生物学、生物反应器、发酵工艺、营养学和食品质量保证等学科。在日常饮食中,发酵食品和饮料因其功能特性和生化成分而具有特殊的重要性。从营养和肥胖的角度来看,食品生物技术产品具有重要意义。酒精摄入热量高,对大脑、肝脏等器官有害,过量饮酒还会引起社会问题,因此必须减少饮酒。在土耳其传统的发酵食品中,如酸奶、开菲尔和kımız、boza、ty和tarhana以及特种泡菜等,具有各种功能特性和对生物体有益的生化化合物。它们含有乳酸菌、益生菌、复合维生素B、营养矿物质和一些特定的化合物,具有预防癌症和肿瘤的发展、心血管疾病和降低胆固醇的作用。食品生物技术还包括转基因生物(GMO)。对食品生物技术的研究也进行了评价。另一方面,另一种重要和常见的发酵产品类型是啤酒,葡萄酒,葡萄酒琼脂,甚至是从碳水化合物来源(如无花果,大麦,小麦,大米或任何碳水化合物来源)产生乙醇的蒸馏酒精饮料。食品生物技术可从食品基础科学和食品生物技术工艺两方面进行评价。对上述主题进行了详细的综述。
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引用次数: 0
期刊
Advances in obesity, weight management & control
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