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Microbiota mitochondrial metabolism 微生物群线粒体代谢
Pub Date : 2018-08-07 DOI: 10.15406/aowmc.2018.08.00251
R. Haddad
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引用次数: 0
From weight management via diabetes control to cardiovascular risk reduction 从通过控制糖尿病控制体重到降低心血管风险
Pub Date : 2018-08-02 DOI: 10.15406/AOWMC.2018.08.00249
Gerald C. Hsu
Since 1997, the author has been diagnosed with three chronic diseases such as type 2 diabetes (T2D), hypertension, and hyperlipidemia. As shown in Figure 1, his health reached to a “near collapsed” condition by 2010; therefore, he launched his type 2 diabetes (T2D) research in order to save his own life. From 2012 to 2018, he has collected and processed approximately 1.5M data regarding his own health and body conditions. During 2010–2013, he studied six chronic diseases and food nutrition in depth. In 2014, using mathematics and various engineering modeling, he developed a mathematical model of the human metabolism system, which contains 11 categories and ~500 elements. Currently, as shown in Figure 1, his chronic disease conditions are now under control. This paper described his effort for 8-years in terms of annualized segments with different working methods utilized at different stages. It specifically discusses the relationship and results from weight management via diabetes control to lowering his risk probabilities of having heart attack or stroke. Figure 1 Comparison of Medical Conditions (2010 vs. 2017).
自1997年以来,作者被诊断患有2型糖尿病(T2D)、高血压、高脂血症等三种慢性疾病。如图1所示,到2010年,他的健康状况达到了“近乎崩溃”的状态;因此,为了挽救自己的生命,他开始了对2型糖尿病(T2D)的研究。从2012年到2018年,他收集并处理了大约150万份关于自己健康和身体状况的数据。2010-2013年,深入研究六种慢性病及食物营养。2014年,他利用数学和各种工程建模,建立了人体代谢系统的数学模型,该模型包含11大类~500个元素。目前,如图1所示,他的慢性疾病已经得到控制。本文以年化分段的形式描述了他8年来的努力,并在不同阶段采用了不同的工作方法。它特别讨论了通过控制糖尿病来控制体重与降低心脏病发作或中风的风险概率之间的关系和结果。图1医疗条件比较(2010年与2017年)。
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引用次数: 2
Gout, obesity and bariatric surgery 痛风,肥胖和减肥手术
Pub Date : 2018-08-01 DOI: 10.15406/AOWMC.2018.08.00248
A. Raziel
Gout is a common arthritis disease, characterized by high serum levels of uric acid. Many risk factors were found to contribute to the development of the disease. Accumulated evidence has pointed out that gout is highly associated with obesity and metabolic syndrome. Moreover, it has been demonstrated by various clinical studies that upon major weight loss, the risk for the development of gout, as well as the frequency of attacks are reduced in correlation with a reduction in the serum uric acid levels.
痛风是一种常见的关节炎疾病,其特点是血清尿酸水平高。人们发现许多危险因素会导致这种疾病的发展。越来越多的证据表明,痛风与肥胖和代谢综合征密切相关。此外,各种临床研究表明,在体重大幅减轻后,患痛风的风险以及发作的频率与血清尿酸水平的降低有关。
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引用次数: 2
The effect of 6–week recreational futsal training on body composition of non–athletic obese girls 6周娱乐性五人制足球训练对非运动性肥胖女生身体成分的影响
Pub Date : 2018-07-26 DOI: 10.15406/aowmc.2018.08.00247
M. Abbaszadegan
Many large observational studies have shown that physical activity and good fitness decrease the risk of coronary heart disease, cardiovascular disease, type 2 diabetes and mortality. Thus, it seems clear that an increase in leisure-time physical activity level and enhancement in cardiorespiratory fitness are ways to reduce the risk of death.1,2 Inactivity is nowadays one of the main causes of cardiovascular disease.3 It was found that a six-month-long inactivity in the Studies resulted in metabolic abnormalities such as an increase in fat mass and visceral fat, and an increase in fasting insulin level, fasting glucose level and small low-density lipoprotein particle number.4 The diverse range of activities carried out by humans for example sitting, standing, walking and talking and by undertaking voluntary physical activity contribute to the overall energy balance. However, physical activity is the only component of energy expenditure that can be modified behaviorally in a significant manner.5 Exercise interventions targeting a broad health response are highly relevant for women of all ages. Given that much of the world’s population is inactive, the association with non-communicable diseases presents a major public health issue. Thus, it is a worldwide challenge to provide initiatives that will get inactive people to become active and increase life healthy in sedentary peoples. Therefore one of the basic items for program training plan is choosing fun activities to create sport situations and competitions that both obviates people’s requirements and leads to the optimum utility and health.6 During the last decades, there has been an increasing interest in the physiological demands of football (soccer) match play and training. Numerous studies have investigated different aspects of the game.7 Researchers have studied the effects of recreational football training as a health-promoting activity for participants across the lifespan. This has important public health implications as over400 million people play football annually.8 Results from the first randomized controlled trial, showed that football increased maximal oxygen uptake and muscle and bone mass, and lowered fat percentage and blood pressure, in untrained men.9 In recent years, the physical loading during small-sided games has also been examined it was found that football training organized as small-sided drills aerobic fitness and intermittent endurance performance were elevated.10 The effect of a period of recreational football has also been examined in middleaged untrained male and female subjects and compared with a similar period of running. they were found that recreational football training stimulated both the aerobic and anaerobic energy turnover during the training of untrained players was shown to be effective leading to significant cardiovascular and muscular adaptations as well as performance enhancements throughout a 12-week training period.8,10,11 In fact, recreation is the l
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引用次数: 0
Epidemiological analysis regarding a BHU (basic health unit) in the region of Maringa–Parana–Brazil 关于马林加-巴拉那-巴西地区一个基本保健单位的流行病学分析
Pub Date : 2018-07-25 DOI: 10.15406/aowmc.2018.08.00246
Anselmo Alexandre Mendes
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引用次数: 0
Overweight/obesity: it is only food and physical activity? 超重/肥胖:仅仅是食物和体育活动?
Pub Date : 2018-07-06 DOI: 10.15406/AOWMC.2018.08.00245
Evangelia Strongilou
a. The speed of eating: In a study in New Zealand the results showed that higher speed of eating is related with higher BMI3 while in a study in Japan the decreases in eating speeds can lead to reduction in BMI.4 This is something that may be related with the fact that when someone is eating fast may lead to the consumption of more food that is needed as he/she does not realize the time he/ she satiates.
a.进食速度:新西兰的一项研究结果表明,进食速度越快,bmi越高,而日本的一项研究结果表明,进食速度越慢,bmi越低。这可能与这样一个事实有关:当一个人吃得快时,他/她可能会摄入更多的食物,因为他/她没有意识到他/她吃饱的时间。
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引用次数: 0
Comparison of micronutrient consumption in women with central obesity in the C/D/E versus A/B socioeconomic classes C/D/E与A/B社会经济阶层中枢性肥胖妇女微量营养素摄入量的比较
Pub Date : 2018-07-03 DOI: 10.15406/AOWMC.2018.08.00250
I. Ferraz, Manuela Pereira Lima Monteiro, Izabela Gelisk, M. L. Lima, Ana Marlee Ladela, Armento Costa Guirnades
The current nutritional issue with the greatest ascent is obesity, taking a hold of individuals of different ages, genders or social classes.1 The prevalence of obesity began to increase in the eighties, being gradual in developed countries with high income and subsequently, a sharp increase reached low income countries, which is the case of Brazil, occupying the third place in absolute numbers of obese people in the last thirty years ( 20 million), behind China (42 million) and the U.S.A. ( 56 million).1 Furthermore, in relation to obesity, we emphasize the increase of central obesity, characterized by an increase in waist circumference due to the preferential storage of body fat in the abdomen is associated to an increase in the risk of developing hypertension, dyslipidemia and diabetes, resulting in an increase in morbidity and mortality from metabolic and cardiovascular diseases.1,2
目前上升最快的营养问题是肥胖,它占据了不同年龄、性别和社会阶层的个体肥胖的流行在80年代开始增加,在高收入的发达国家逐渐增加,随后在低收入国家急剧增加,巴西的情况是,在过去三十年中,肥胖人口的绝对数量排名第三(2000万),仅次于中国(4200万)和美国(5600万)此外,关于肥胖,我们强调中心性肥胖的增加,其特征是由于身体脂肪优先储存在腹部而导致腰围增加,这与患高血压、血脂异常和糖尿病的风险增加有关,从而导致代谢和心血管疾病的发病率和死亡率增加1,2
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引用次数: 0
A study to evaluate chalcurb® a standardized powder derived from the sap of the Angelica keiskei (Ashitaba) on markers of health in adults with metabolic syndrome 一项评估chalcurb®的研究,chalcurb®是一种从白芷(Ashitaba)的汁液中提取的标准化粉末,对代谢综合征成人健康标志物的影响
Pub Date : 2018-07-03 DOI: 10.15406/aowmc.2018.08.00244
D. Kalman, S. Hewlings, V. Hackel
There is a growing trend for the use of medicinal plants for a variety of health concerns. One prevalent health concern is obesity. This is perhaps for good reason; in the United States from 2011 to 2012, nearly two-thirds of adults were obese or overweight.1 Both pharmaceutical and behavioral interventions have had a limited success rate, suggesting that prevention may be the ideal approach. Ashitaba, also known as Angelica keiski, is a plant found to contain a class of physiologically active flavonoids known as chalcones, which are abundantly found in the sap and to a lesser extent in the leaf and roots.2–7 Of the more than 20 chalcones that are found in ashitaba sap, two are 4-hydroxyderricin (4-HD) and xanthoangelol (XA).2–5 Specifically, in vitro and in vivo studies have demonstrated the antiobesity and anti-diabetic actions of ashitaba and its associated active chalcones.3 In a recent study, it was found that administration of isolated 4-HD from ashitaba in hyperglycemic KK-Ay mice resulted in modest suppression of elevated blood glucose levels without adverse side effects.5 Compared to the complete suppression of the development of diabetes via pioglitazone administration, daily consumption of ashitaba has been considered beneficial to hyperglycemic individuals not undergoing drug treatment for diabetes.5
利用药用植物治疗各种健康问题的趋势日益增长。一个普遍的健康问题是肥胖。这也许是有充分理由的;在美国,从2011年到2012年,近三分之二的成年人肥胖或超重药物和行为干预都有有限的成功率,这表明预防可能是理想的方法。白芷,也被称为当归,是一种被发现含有一类被称为查尔酮的生理活性类黄酮的植物,它在汁液中含量丰富,在叶子和根中含量较少。在木叶树液中发现的20多种查尔酮中,有两种是4-羟基蓖麻素(4-HD)和黄原angelol (XA)。2-5具体来说,体外和体内研究已经证明了明日叶及其相关活性查尔酮的抗肥胖和抗糖尿病作用在最近的一项研究中,研究人员发现,在高血糖的KK-Ay小鼠中施用从木叶中分离的4-HD可适度抑制血糖水平升高,且无不良副作用与通过吡格列酮完全抑制糖尿病的发展相比,每日食用明日叶被认为对未接受糖尿病药物治疗的高血糖患者有益
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引用次数: 1
Dietary omega-3 polyunsaturated fatty acids and treatment of cancer 饮食中的omega-3多不饱和脂肪酸和癌症的治疗
Pub Date : 2018-06-26 DOI: 10.15406/AOWMC.2018.08.00243
B. Abiri, M. Vafa
Global cancer incidence and mortality rates are high and elevating. Worldwide, it is estimated that the annual number of cancer diagnoses will promote to 22 million by 2032.1 In spite of progress made in cancer chemotherapy, advanced solid tumors consisting of advanced carcinomas, sarcomas, melanoma, and glioblastoms, yet show wide problems in their treatment and traditional therapeutic agents alone have not produced satisfactory long-term clinical outcomes.2,3 Also, in those cases which the tumor has seemingly been eliminated fully, micro-metastases of inactive tumor cells often result to relapse and to therapeutic failing. Hence, considering the problems of scape and survival to cancer progress, most oncologists have concluded that no unique therapy is enough to treatment of cancer.4,5
全球癌症发病率和死亡率很高,而且还在上升。在世界范围内,预计到2032年,每年的癌症诊断数量将增加到2200万例。尽管癌症化疗取得了进展,但晚期实体瘤包括晚期癌、肉瘤、黑色素瘤和胶质母细胞瘤,但在治疗上存在广泛的问题,仅靠传统的治疗药物并不能产生令人满意的长期临床效果。2,3此外,在那些肿瘤似乎已经完全消除的病例中,无活性肿瘤细胞的微转移往往导致复发和治疗失败。因此,考虑到癌症进展的逃逸和生存问题,大多数肿瘤学家得出结论,没有一种独特的治疗方法足以治疗癌症
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引用次数: 0
Role of prebiotics on the microbiote 益生元对微生物的作用
Pub Date : 2018-06-25 DOI: 10.15406/AOWMC.2018.08.00242
R. Haddad
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引用次数: 0
期刊
Advances in obesity, weight management & control
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