{"title":"Fipronil Induced Hepatotoxicity, Genotoxicity, Oxidative Stress and the Possible Ameliorative Effect of Ginseng","authors":"M. Al-harbi","doi":"10.9734/BJPR/2016/23660","DOIUrl":"https://doi.org/10.9734/BJPR/2016/23660","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"43 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82573512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. El-Mahdy, T. El-Masry, K. El-Desouky, Sahar M. M. Ghanem
{"title":"The Renal and Cardio Protective Effects of Aliskiren and Pentoxifylline Alone and in Combination on Streptozotocin Induced Diabetic Rats","authors":"N. El-Mahdy, T. El-Masry, K. El-Desouky, Sahar M. M. Ghanem","doi":"10.9734/BJPR/2016/26248","DOIUrl":"https://doi.org/10.9734/BJPR/2016/26248","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"55 7 Suppl 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80957528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Saif, Waddaah Al-Asbahy, A. Al-Fakih, A. Albadani
{"title":"Serum CA19–9 Levels and Pancreatic Beta Cell Destruction in Type 2 Diabetes Mellitus Patients","authors":"M. Saif, Waddaah Al-Asbahy, A. Al-Fakih, A. Albadani","doi":"10.9734/BJPR/2016/30808","DOIUrl":"https://doi.org/10.9734/BJPR/2016/30808","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"13 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82794661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Samarakoon, N. Fernando, M. Ediriweera, A. Adhikari, Lakshan Wijayabandara, E. D. D. Silva, K. Tennekoon
Aims: The present study was aimed to isolate active anti proliferative compound/s from the hexane extract of leaves of the mangrove plant Scyphiphora hydrophyllacea C.F.Gaertn. and evaluate their cytotoxic properties. Place and Duration of the Study: At the Institute of Biochemistry, Molecular Biology and Biotechnology and HEJ Research Institute of Chemistry, between January 2015 to November 2015. Methodology: The hexane extract of the leaves of S. hydrophyllacea which was found to be cytotoxic was fractionated using normal phase column chromatography and fractions obtained from Original Research Article Samarakkon et al.; BJPR, 10(1): 1-6, 2016; Article no.BJPR.23317 2 column chromatography were tested for anti proliferative effects. Active fractions obtained were further fractionated using normal phase column chromatography to obtain compound 1. Structure of the isolated compound was elucidated with combination of Hand C-NMR spectroscopy, and mass spectrometry techniques. Anti proliferative properties of compound 1 in three cancer cell lines {MCF-7 (estrogen receptor positive breast cancer), HepG2 (hepatocellular carcinoma) and AN3CA (endometrial cancer)} was evaluated by MTT assay after 24 and 48 h incubations. Results: Isolated compound was found to be hopenone-I, a triterpenoid and this is a novel finding for the presence this compound in the mangrove plant S. hydrophyllacea. Hopenone-I showed some promising anti proliferative effects in all the cancer cells in a time and dose dependent manner after 24 and 48 h incubations {MCF-7: 14.98 μM (24 h) and 7.76 μM (48 h), HepG2: 29.24 μM (24 h) and 11.60 μM (48 h), AN3CA: 12.15 μM (24 h) and 4.99 μM (48 h)}. Conclusion: Based on the overall results of the present study, we conclude that hopenone-I isolated for the first time from S. hydrophyllacea leaves possess prominent anti proliferative effects in MCF-7, AN3CA and HepG2 cell lines.
{"title":"Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties","authors":"S. Samarakoon, N. Fernando, M. Ediriweera, A. Adhikari, Lakshan Wijayabandara, E. D. D. Silva, K. Tennekoon","doi":"10.9734/bjpr/2016/23317","DOIUrl":"https://doi.org/10.9734/bjpr/2016/23317","url":null,"abstract":"Aims: The present study was aimed to isolate active anti proliferative compound/s from the hexane extract of leaves of the mangrove plant Scyphiphora hydrophyllacea C.F.Gaertn. and evaluate their cytotoxic properties. Place and Duration of the Study: At the Institute of Biochemistry, Molecular Biology and Biotechnology and HEJ Research Institute of Chemistry, between January 2015 to November 2015. Methodology: The hexane extract of the leaves of S. hydrophyllacea which was found to be cytotoxic was fractionated using normal phase column chromatography and fractions obtained from Original Research Article Samarakkon et al.; BJPR, 10(1): 1-6, 2016; Article no.BJPR.23317 2 column chromatography were tested for anti proliferative effects. Active fractions obtained were further fractionated using normal phase column chromatography to obtain compound 1. Structure of the isolated compound was elucidated with combination of Hand C-NMR spectroscopy, and mass spectrometry techniques. Anti proliferative properties of compound 1 in three cancer cell lines {MCF-7 (estrogen receptor positive breast cancer), HepG2 (hepatocellular carcinoma) and AN3CA (endometrial cancer)} was evaluated by MTT assay after 24 and 48 h incubations. Results: Isolated compound was found to be hopenone-I, a triterpenoid and this is a novel finding for the presence this compound in the mangrove plant S. hydrophyllacea. Hopenone-I showed some promising anti proliferative effects in all the cancer cells in a time and dose dependent manner after 24 and 48 h incubations {MCF-7: 14.98 μM (24 h) and 7.76 μM (48 h), HepG2: 29.24 μM (24 h) and 11.60 μM (48 h), AN3CA: 12.15 μM (24 h) and 4.99 μM (48 h)}. Conclusion: Based on the overall results of the present study, we conclude that hopenone-I isolated for the first time from S. hydrophyllacea leaves possess prominent anti proliferative effects in MCF-7, AN3CA and HepG2 cell lines.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"3 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90202638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antimicrobial Activity of Bridelia micrantha and Grewia plagiophylla Leaf Extracts","authors":"K. Douglas, Alex Gitonga","doi":"10.9734/BJPR/2016/27270","DOIUrl":"https://doi.org/10.9734/BJPR/2016/27270","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"56 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86555153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thesium viride Hill (Santalaceae) is a sub-shrub hemiparasite that grows up to 45 cm tall and widely distributed in Europe, Asia and Africa. It is used ethno medicinally in ulcer, jaundice and splenomegally. Phytochemical screening was carried out on the aqueous ethanol extract of the whole plant by using standard phytochemical methods. Antibacterial studies were also carried out on the aqueous ethanol extract by using diffusion method and broth dilution methods. The aqueous ethanol extract of the plant was found to contain alkaloids, flavonoids, anthraquinones, saponins and cardiac glycosides. The aqueous extract was found to be active against Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Helicobacter pylori and Shigella dysenteriae and had minimum inhibitory concentrations (MIC) of 10, 5, 5, 5, and 5 mg/ml and also minimum bactericidal concentration (MBC) of 20, 20, 20, 10, and 10 mg/ml respectively. The extract was also found to be inactive against Corynbacterium ulcerans and Salmonella typhii. Zones of inhibition produced by aqueous ethanol extract of plant were less than those produced by Original Research Article Shehu et al.; BJPR, 11(2): 1-6, 2016; Article no.BJPR.23046 2 ciprofloxacin (5 μg/ml). The aqueous ethanol extract of the plant could serve as an antibacterial agent on the sensitive bacteria based on the study.
{"title":"Phytochemical and Antibacterial Studies on Aqueous Ethanol Extract of Thesium viride (Santalaceae)","authors":"S. Shehu, M. Abubakar, G. Ibrahim, U. Iliyasu","doi":"10.9734/BJPR/2016/23046","DOIUrl":"https://doi.org/10.9734/BJPR/2016/23046","url":null,"abstract":"Thesium viride Hill (Santalaceae) is a sub-shrub hemiparasite that grows up to 45 cm tall and widely distributed in Europe, Asia and Africa. It is used ethno medicinally in ulcer, jaundice and splenomegally. Phytochemical screening was carried out on the aqueous ethanol extract of the whole plant by using standard phytochemical methods. Antibacterial studies were also carried out on the aqueous ethanol extract by using diffusion method and broth dilution methods. The aqueous ethanol extract of the plant was found to contain alkaloids, flavonoids, anthraquinones, saponins and cardiac glycosides. The aqueous extract was found to be active against Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Helicobacter pylori and Shigella dysenteriae and had minimum inhibitory concentrations (MIC) of 10, 5, 5, 5, and 5 mg/ml and also minimum bactericidal concentration (MBC) of 20, 20, 20, 10, and 10 mg/ml respectively. The extract was also found to be inactive against Corynbacterium ulcerans and Salmonella typhii. Zones of inhibition produced by aqueous ethanol extract of plant were less than those produced by Original Research Article Shehu et al.; BJPR, 11(2): 1-6, 2016; Article no.BJPR.23046 2 ciprofloxacin (5 μg/ml). The aqueous ethanol extract of the plant could serve as an antibacterial agent on the sensitive bacteria based on the study.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"11 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85794081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HPLC, Densitometric and Visible-Spectrophotometric Determination of Triclabendazole and Ivermectin","authors":"S. Razeq, A. El-Demerdash, Hoda El-Sanabary","doi":"10.9734/BJPR/2016/29196","DOIUrl":"https://doi.org/10.9734/BJPR/2016/29196","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"8 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88670048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In the present time use of pesticides has become very common by the farmers for the better yield of crops. Endosulfan, a chlorinated cyclodiene insecticide, is widely and very liberally used in agricultural sector. But it has created deleterious effects on human health. Objective: In the present study amelioration effect of Emblica officinalis (E. officinalis) extract on ovary in Endosulfan induced Swiss albino mice was studied. Materials and Methods: Three groups were formed, each with six mice. The control group of mice received distilled water as drinking water. The second group was exposed to Endosulfan @ 3 mg/kg body weight daily for 6 weeks by Gavage method. The third group was exposed to Endosulfan @ 3 mg/kg body weight daily for 6 weeks followed by 6 weeks exposed to E. officinalis (100 mg/kg body weight) extract. Animals were sacrificed after the schedule treatment. Results and Discussion: Light microscopic observations showed various histopathological deformities in sections of treated ovary and improper development of follicle such as detached ova Original Research Article Sinha and Kumari; BJPR, 11(2): 1-9, 2016; Article no.BJPR.17669 2 and degeneration of follicular cells due to Endosulfan exposure were also found. The present studies also indicate that alterations were found to be significantly ameliorated in E. officinalis extract treated group. Conclusion: It may be concluded from this study that E. officinalis have a potent capacity to control Endosulfan induced toxicity.
{"title":"Amelioration Effect of Emblica officinalis Extract on Ovary in Endosulfan Induced Swiss Albino Mice","authors":"P. Sinha, A. Kumari","doi":"10.9734/BJPR/2016/17669","DOIUrl":"https://doi.org/10.9734/BJPR/2016/17669","url":null,"abstract":"Background: In the present time use of pesticides has become very common by the farmers for the better yield of crops. Endosulfan, a chlorinated cyclodiene insecticide, is widely and very liberally used in agricultural sector. But it has created deleterious effects on human health. Objective: In the present study amelioration effect of Emblica officinalis (E. officinalis) extract on ovary in Endosulfan induced Swiss albino mice was studied. Materials and Methods: Three groups were formed, each with six mice. The control group of mice received distilled water as drinking water. The second group was exposed to Endosulfan @ 3 mg/kg body weight daily for 6 weeks by Gavage method. The third group was exposed to Endosulfan @ 3 mg/kg body weight daily for 6 weeks followed by 6 weeks exposed to E. officinalis (100 mg/kg body weight) extract. Animals were sacrificed after the schedule treatment. Results and Discussion: Light microscopic observations showed various histopathological deformities in sections of treated ovary and improper development of follicle such as detached ova Original Research Article Sinha and Kumari; BJPR, 11(2): 1-9, 2016; Article no.BJPR.17669 2 and degeneration of follicular cells due to Endosulfan exposure were also found. The present studies also indicate that alterations were found to be significantly ameliorated in E. officinalis extract treated group. Conclusion: It may be concluded from this study that E. officinalis have a potent capacity to control Endosulfan induced toxicity.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"88 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77151719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-inflammatory and Antioxidant Activities of Mimusops elengi L.","authors":"H. Zahid, G. Rizwani, Madiha Khan, S. Khalid","doi":"10.9734/bjpr/2016/18865","DOIUrl":"https://doi.org/10.9734/bjpr/2016/18865","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"1 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77583294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The focus of this research work was to develop a melt granulation technique to enhance solubility, dissolution rate and associated flowability concerns of Ibuprofen. Hydrophilic excipients like xylitol and lactose anhydrous were added to the binary mixture of conventional low melting surfactant Poloxamer 407 and Ibuprofen. Physical mixtures of Ibuprofen and Poloxamer 407 were prepared in ratios of 1:0.25, 1:0.5 and 1:0.75 using a water-jacketed high shear mixer. For each ratio of Ibuprofen and Poloxamer 407, xylitol and lactose anhydrous were added separately at two levels (75 mg and 150 mg) per unit dose containing 200 mg drug. Phase solubility studies revealed linearity in drug solubility enhancement with Poloxamer 407 concentration. In vitro dissolution studies were carried out for drug, physical mixtures (PM) and melt granules (MG) for all ratios in de-ionized water and 0.1 N HCl (pH=1.2). Solid state characterization was performed using Fourier transform infrared spectroscopy (FTIR), modulated differential scanning calorimetry (mDSC) and Original Research Article Gajera et al.; BJPR, 13(6): 1-19, 2016; Article no.BJPR.29048 2 powder X-ray diffraction (PXRD) methodologies. Powder rheology studies were performed conventionally by measuring Carr’s index and Hausner’s ratio. Basic flowability energy values were calculated using a powder rheometer to corroborate flowability data measured by conventional methods. Particle morphological studies were done by Scanning electron microscope (SEM) and Fluid imaging technologies. In-vitro dissolution studies showed approximately 7 fold drug release in water and 19 fold drug release in acidic media for MG 1:0.75 at hydrophilic excipient level of 150 mg compared to that of neat Ibuprofen in respective dissolution media. mDSC and PXRD data confirms crystalline nature of drug in the formulations. FTIR data confirms no interactions between drug and excipients used during processing. Particle morphology analysis confirms absence of rhombic Ibuprofen crystals in formulations. Dissolution rate and solubility enhancement was seen due to synergistic effects of Poloxamer 407 and hydrophilic excipients incorporated in formulations.
本研究的重点是开发一种熔体造粒技术，以提高布洛芬的溶解度、溶出率和相关的流动性问题。在传统低熔点表面活性剂poloxam407和布洛芬二元混合物中加入木糖醇和无水乳糖等亲水性辅料。采用水套式高剪切混合器，按1:0.25、1:0.5和1:0.75的比例配制布洛芬和波洛沙姆407的物理混合物。在布洛芬和波洛沙姆407的每一比例中，木糖醇和无水乳糖分别以两种水平(75 mg和150 mg)添加，每单位剂量含有200 mg药物。相溶解度研究表明，药物溶解度随波洛沙姆407浓度的增加呈线性关系。对药物、物理混合物(PM)和熔融颗粒(MG)在去离子水和0.1 N HCl (pH=1.2)中以各种比例进行体外溶出研究。采用傅里叶变换红外光谱(FTIR)、调制差示扫描量热法(mDSC)和原始研究文章Gajera等进行固态表征;生物工程学报，13(6):1-19,2016;文章no.BJPR。29048粉末x射线衍射(PXRD)方法。粉末流变学研究通常是通过测量卡尔指数和豪斯纳比来进行的。用粉末流变仪计算了基本流动能值，以证实传统方法测量的流动能值。通过扫描电子显微镜(SEM)和流体成像技术对颗粒形态进行了研究。体外溶出度研究表明，当亲水性赋形剂浓度为150 MG时，与纯布洛芬在各自溶出介质中的药物释放量相比，在水中的药物释放量约为7倍，在酸性介质中的药物释放量为19倍。mDSC和PXRD数据证实了制剂中药物的结晶性。FTIR数据证实在加工过程中使用的药物和辅料之间没有相互作用。颗粒形态分析证实配方中不含菱形布洛芬晶体。溶解速率和溶解度的提高是由于poloxam407和亲水性赋形剂的协同作用。
{"title":"Formulation Development and Optimization of Ibuprofen Poloxamer Melt Granules Using Hydrophilic Excipients","authors":"B. Gajera, R. Dugar, R. Dave","doi":"10.9734/BJPR/2016/29048","DOIUrl":"https://doi.org/10.9734/BJPR/2016/29048","url":null,"abstract":"The focus of this research work was to develop a melt granulation technique to enhance solubility, dissolution rate and associated flowability concerns of Ibuprofen. Hydrophilic excipients like xylitol and lactose anhydrous were added to the binary mixture of conventional low melting surfactant Poloxamer 407 and Ibuprofen. Physical mixtures of Ibuprofen and Poloxamer 407 were prepared in ratios of 1:0.25, 1:0.5 and 1:0.75 using a water-jacketed high shear mixer. For each ratio of Ibuprofen and Poloxamer 407, xylitol and lactose anhydrous were added separately at two levels (75 mg and 150 mg) per unit dose containing 200 mg drug. Phase solubility studies revealed linearity in drug solubility enhancement with Poloxamer 407 concentration. In vitro dissolution studies were carried out for drug, physical mixtures (PM) and melt granules (MG) for all ratios in de-ionized water and 0.1 N HCl (pH=1.2). Solid state characterization was performed using Fourier transform infrared spectroscopy (FTIR), modulated differential scanning calorimetry (mDSC) and Original Research Article Gajera et al.; BJPR, 13(6): 1-19, 2016; Article no.BJPR.29048 2 powder X-ray diffraction (PXRD) methodologies. Powder rheology studies were performed conventionally by measuring Carr’s index and Hausner’s ratio. Basic flowability energy values were calculated using a powder rheometer to corroborate flowability data measured by conventional methods. Particle morphological studies were done by Scanning electron microscope (SEM) and Fluid imaging technologies. In-vitro dissolution studies showed approximately 7 fold drug release in water and 19 fold drug release in acidic media for MG 1:0.75 at hydrophilic excipient level of 150 mg compared to that of neat Ibuprofen in respective dissolution media. mDSC and PXRD data confirms crystalline nature of drug in the formulations. FTIR data confirms no interactions between drug and excipients used during processing. Particle morphology analysis confirms absence of rhombic Ibuprofen crystals in formulations. Dissolution rate and solubility enhancement was seen due to synergistic effects of Poloxamer 407 and hydrophilic excipients incorporated in formulations.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"5 1","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90320769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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