{"title":"Bersama abyssinica Fresen. (Melianthaceae): Antifungal Activity on Aflatoxin B1-producing Mold","authors":"K. Bene, A. Kra, K. Konan, G. Zirihi","doi":"10.9734/BJPR/2017/31695","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31695","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"9 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76352355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Singh, Dhiraj Kumar, A. Mishra, S. Arora, Durgesh Kumar, Sagar Pamu, H. B. Samal, Velupula Nishanth
{"title":"Development of Validated RP-HPLC Method for Simultanious Estimation of Cefadroxil and Ambroxol in Pure and Pharmaceutical Dosage Form","authors":"T. Singh, Dhiraj Kumar, A. Mishra, S. Arora, Durgesh Kumar, Sagar Pamu, H. B. Samal, Velupula Nishanth","doi":"10.9734/bjpr/2017/32225","DOIUrl":"https://doi.org/10.9734/bjpr/2017/32225","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"24 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79291919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. M. Jamil, Mahamudul Haque, M. W. Rahman, T. Emran, R. Chowdhury, F. Nasrin, Chowdhoury Hasan
{"title":"Monitoring of Pesticide Poisoning in Different Occupational Groups by the Estimation of Serum Cholinesterase (PChE), ALT, AST & Bilirubin","authors":"H. M. Jamil, Mahamudul Haque, M. W. Rahman, T. Emran, R. Chowdhury, F. Nasrin, Chowdhoury Hasan","doi":"10.9734/bjpr/2017/33468","DOIUrl":"https://doi.org/10.9734/bjpr/2017/33468","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"35 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89801855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The well-being and satisfaction with life are two indicators of mental health. The aim of this study was to evaluate the relationship between mindfulness and psychological well-being, and coping strategies with stress in female basketball athletes in Tehran. Methods and Materials: Among all women basketball athletes in Tehran in 2016, two-hundred and fifty women were randomly selected. All samples completed Lazarus and Folkman coping strategies questionnaire, Ryff Psychological well-being Questionnaire and Freiburg Mindfulness Inventory. Data were analyzed using Pearson correlation and multiple regression inSpss-22. Original Research Article Fazli and Ghahari; BJPR, 17(2): 1-8, 2017; Article no.BJPR.34105 2 Results: The results confirmed the hypothesis of this study and suggested a significant positive relationship between the components of mindfulness and psychological well-being, and coping with stress strategies (p<0.01). Conclusion: There was a significant positive relationship between components of mindfulness and psychological well-being, and coping strategies with stress.
{"title":"The Relationship between Mindfulness and Psychological Well-being and Coping Strategies with Stress among Female Basketball Athletes in Tehran","authors":"Z. Fazli, S. Ghahari","doi":"10.9734/BJPR/2017/34105","DOIUrl":"https://doi.org/10.9734/BJPR/2017/34105","url":null,"abstract":"Introduction: The well-being and satisfaction with life are two indicators of mental health. The aim of this study was to evaluate the relationship between mindfulness and psychological well-being, and coping strategies with stress in female basketball athletes in Tehran. Methods and Materials: Among all women basketball athletes in Tehran in 2016, two-hundred and fifty women were randomly selected. All samples completed Lazarus and Folkman coping strategies questionnaire, Ryff Psychological well-being Questionnaire and Freiburg Mindfulness Inventory. Data were analyzed using Pearson correlation and multiple regression inSpss-22. Original Research Article Fazli and Ghahari; BJPR, 17(2): 1-8, 2017; Article no.BJPR.34105 2 Results: The results confirmed the hypothesis of this study and suggested a significant positive relationship between the components of mindfulness and psychological well-being, and coping with stress strategies (p<0.01). Conclusion: There was a significant positive relationship between components of mindfulness and psychological well-being, and coping strategies with stress.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"1 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89685453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The present study investigates the capability of preparing metronidazole loaded microspheres employing a natural chitosan extracted from oyster shells of Egeria radiata. Methods: Microspheres were prepared by external gelation technique using tripolyphosphate (TPP) as the cross-linker. The drug to polymer ratio was selected at various levels of polymer-drug quantities with varying amount of TPP. The prepared microspheres were characterized for % yield, drug entrapment efficiency, surface morphology and drug release profile. Results: Almost spherical, rough and porous microspheres were obtained. % yield and drug entrapment efficiency were found to be in the range of 63.5 – 70.8% and 63.4 – 77.5% respectively; and about 80% of the drug was released in about 6 hours. Conclusion: The results revealed that formulation of metronidazole loaded microspheres in natural chitosan from an oyster shell can be used as a potential oral drug delivery system. Original Research Article Majekodunmi and Akpan; BJPR, 17(1): 1-11, 2017; Article no.BJPR.33247 2
{"title":"Comparative Study for In-vitro Evaluation of Metronidazole Prepared Using Natural Chitosan from Oyster Shells of Egeria radiata","authors":"S. Majekodunmi, Ekefre-Abasi Akpan","doi":"10.9734/BJPR/2017/33247","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33247","url":null,"abstract":"Objective: The present study investigates the capability of preparing metronidazole loaded microspheres employing a natural chitosan extracted from oyster shells of Egeria radiata. Methods: Microspheres were prepared by external gelation technique using tripolyphosphate (TPP) as the cross-linker. The drug to polymer ratio was selected at various levels of polymer-drug quantities with varying amount of TPP. The prepared microspheres were characterized for % yield, drug entrapment efficiency, surface morphology and drug release profile. Results: Almost spherical, rough and porous microspheres were obtained. % yield and drug entrapment efficiency were found to be in the range of 63.5 – 70.8% and 63.4 – 77.5% respectively; and about 80% of the drug was released in about 6 hours. Conclusion: The results revealed that formulation of metronidazole loaded microspheres in natural chitosan from an oyster shell can be used as a potential oral drug delivery system. Original Research Article Majekodunmi and Akpan; BJPR, 17(1): 1-11, 2017; Article no.BJPR.33247 2","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"26 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78213451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-Cancerous Efficacy of Alcoholic and Aqueous Extracts from an Endemic Plant Thermopsis turcica on Liver Carcinoma","authors":"M. Ali, İ. Ciğerci","doi":"10.9734/BJPR/2017/32413","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32413","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"26 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84995330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical investigation of the marine sponge Ircinia fusca leads to isolation of a new pyrrole derivative (1) and two known compounds namely, 3 methyl decanoic acid (2) and Benzenedicarboxylic acid (3). The structures of compounds were established by 1D and 2D NMR and MS data. Compound 1 exhibited strong antibacterial activity against Mycobacterium smegmatis at MIC 116 μM. Compounds 1-3 showed neither antifungal nor cytotoxic activity.
{"title":"Anti-Mycobacterium Metabolite from Marine Sponge Iricinia fusca","authors":"S. Meesala, Ruby Singh, M. Watve","doi":"10.9734/bjpr/2017/32881","DOIUrl":"https://doi.org/10.9734/bjpr/2017/32881","url":null,"abstract":"Chemical investigation of the marine sponge Ircinia fusca leads to isolation of a new pyrrole derivative (1) and two known compounds namely, 3 methyl decanoic acid (2) and Benzenedicarboxylic acid (3). The structures of compounds were established by 1D and 2D NMR and MS data. Compound 1 exhibited strong antibacterial activity against Mycobacterium smegmatis at MIC 116 μM. Compounds 1-3 showed neither antifungal nor cytotoxic activity.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"12 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75444865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacokinetic Characterization of Piperaquine in Nigerian Healthy Volunteers after Co-administration with a Commercial Brand of Moringa Tea","authors":"Alero Iseh, A. Adegbola, B. Adeagbo","doi":"10.9734/BJPR/2017/32723","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32723","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"63 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74828275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Liman, F. Çoban, İ. Ciğerci, I. Bulduk, Ş. Bozkurt
Oleuropein is a fundamental polyphenol contained in olive fruit, oil, and leaf, with a bitter taste. A decrease in its level is observed as the fruit ripens. Leaves of oil tree were used in this study as a possible origin of oleuropein. In this study, cytotoxic, genotoxic, apoptotic and antiangiogenic impacts of isolated oleuropein (0.5xIC50, IC50 and 2xIC50) on MCF-7 human breast adenocarcinoma cells were examined by means of 3-[4,5Dimethylthiazol-2-yl] 1-2,5diphenyltetrazolium bromide (XTT) kit, Comet assay, Poly (ADP-Ribose) Polymerase (PARP) cleavage ELISA Kit and Vascular Endothelial Growth Factor (VEGF) Human ELISA Kit for 24, 48 and 72 h, respectively. The IC50 value of oleuropein on MCF-7 cells was found to be 11.02±0.52, 9.43±0.41 and 6.81±0.18 μg/mL for 24, 48 and 72 h, respectively. The time and concentrationrelated cytotoxic impacts of oleuropein were determined to be significant. Cleaved PARP level was Original Research Article Liman et al.; BJPR, 16(4): 1-10, 2017; Article no.BJPR.33403 2 significantly increased especially with an increase in the concentration of oleuropein. However, a significant decrease in VEGF level was observed (p<0.05). Furthermore, oleuropein increased damage on DNA for 48 and 72 h. Findings showed oleuropein as a potential antiangiogenic, apoptotic and genotoxic agent for the breast cancer cells.
{"title":"Antiangiogenic and Apoptotic Effects of Oleuropein on Breast Cancer Cells","authors":"R. Liman, F. Çoban, İ. Ciğerci, I. Bulduk, Ş. Bozkurt","doi":"10.9734/BJPR/2017/33403","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33403","url":null,"abstract":"Oleuropein is a fundamental polyphenol contained in olive fruit, oil, and leaf, with a bitter taste. A decrease in its level is observed as the fruit ripens. Leaves of oil tree were used in this study as a possible origin of oleuropein. In this study, cytotoxic, genotoxic, apoptotic and antiangiogenic impacts of isolated oleuropein (0.5xIC50, IC50 and 2xIC50) on MCF-7 human breast adenocarcinoma cells were examined by means of 3-[4,5Dimethylthiazol-2-yl] 1-2,5diphenyltetrazolium bromide (XTT) kit, Comet assay, Poly (ADP-Ribose) Polymerase (PARP) cleavage ELISA Kit and Vascular Endothelial Growth Factor (VEGF) Human ELISA Kit for 24, 48 and 72 h, respectively. The IC50 value of oleuropein on MCF-7 cells was found to be 11.02±0.52, 9.43±0.41 and 6.81±0.18 μg/mL for 24, 48 and 72 h, respectively. The time and concentrationrelated cytotoxic impacts of oleuropein were determined to be significant. Cleaved PARP level was Original Research Article Liman et al.; BJPR, 16(4): 1-10, 2017; Article no.BJPR.33403 2 significantly increased especially with an increase in the concentration of oleuropein. However, a significant decrease in VEGF level was observed (p<0.05). Furthermore, oleuropein increased damage on DNA for 48 and 72 h. Findings showed oleuropein as a potential antiangiogenic, apoptotic and genotoxic agent for the breast cancer cells.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"72 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75675729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Nurten, Dalaklioğlu Selvinaz, Bigat Zekiye, Karsli Bilge, Tasatargil Arda
{"title":"Comparison of the Effects of Ropivacaine and Bupivacaine on Human Umblical Artery Vasoreactivity","authors":"K. Nurten, Dalaklioğlu Selvinaz, Bigat Zekiye, Karsli Bilge, Tasatargil Arda","doi":"10.9734/BJPR/2017/32591","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32591","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"13 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79395826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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