Background: Macrotyloma uniflorum (Horse gram) seeds are used in Ayurvedic medicine for treating numerous health disorders including rheumatism, worm, conjunctivitis and piles. The seeds were boiled with water and used as a folklore medicine for treatment of jaundice in Andhra Pradesh, India. Aim: The present study was aimed to find out the therapeutic potentials of M. uniflorum seeds Original Research Article Mohgana et al.; BJPR, 15(5): 1-9, 2017; Article no.BJPR.32457 2 extract against paracetamolinduced hepatotoxicity and also to scientifically prove its traditional claim. Methodology: Hepatotoxicity was induced in wistar albino rats by the oral administration of paracetamol (400 mg/kg b.wt.) for 10 days. The ethanolic extract and water extract (400 mg/kg b.wt.) were orally administered to the respective group once daily for 10 days. Silymarin (20 mg/kg b.wt.) was used as standard. Biochemical parameters such as ASAT, ALAT, ALP, TP, albumin, globulin, total bilirubin and GGT were determined to assess the hepatoprotective effect. Results: The oral administration of both ethanolic and water extracts significantly (P<0.001) restored the biochemical parameters in the hepatotoxicated rats which were well compared with standard drug silymarin. The hepatoprotective activity of ethanolic extract provides therapeutically better efficacy which was further supported by histopathological examination. The phytochemical screening reveals the presence of phytoconstituents such as phenolic compounds, flavonoids and alkaloids which might be responsible for the hepatoprotective activity. Conclusion: The scientific establishment of the M. uniflorum was traditionally claimed by folklore medicine was validated.
{"title":"Hepatoprotective Activity of Macrotyloma uniflorum (Lam.) Verdc. Seeds Extracts Against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats","authors":"Mohgana Ramasamy, Anbu Jeba Sunilson John Samuel, Anandarajagopal Kalusalingam, Krupavaram Bethala","doi":"10.9734/BJPR/2017/32457","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32457","url":null,"abstract":"Background: Macrotyloma uniflorum (Horse gram) seeds are used in Ayurvedic medicine for treating numerous health disorders including rheumatism, worm, conjunctivitis and piles. The seeds were boiled with water and used as a folklore medicine for treatment of jaundice in Andhra Pradesh, India. Aim: The present study was aimed to find out the therapeutic potentials of M. uniflorum seeds Original Research Article Mohgana et al.; BJPR, 15(5): 1-9, 2017; Article no.BJPR.32457 2 extract against paracetamolinduced hepatotoxicity and also to scientifically prove its traditional claim. Methodology: Hepatotoxicity was induced in wistar albino rats by the oral administration of paracetamol (400 mg/kg b.wt.) for 10 days. The ethanolic extract and water extract (400 mg/kg b.wt.) were orally administered to the respective group once daily for 10 days. Silymarin (20 mg/kg b.wt.) was used as standard. Biochemical parameters such as ASAT, ALAT, ALP, TP, albumin, globulin, total bilirubin and GGT were determined to assess the hepatoprotective effect. Results: The oral administration of both ethanolic and water extracts significantly (P<0.001) restored the biochemical parameters in the hepatotoxicated rats which were well compared with standard drug silymarin. The hepatoprotective activity of ethanolic extract provides therapeutically better efficacy which was further supported by histopathological examination. The phytochemical screening reveals the presence of phytoconstituents such as phenolic compounds, flavonoids and alkaloids which might be responsible for the hepatoprotective activity. Conclusion: The scientific establishment of the M. uniflorum was traditionally claimed by folklore medicine was validated.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"23 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74699250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vandana Chaudhary, S. Hussain, V. Jain, V. Prakash, R. Khar, Sushruti Sharma
{"title":"Formulation and Characterization of Solid Lipid Nanoparticles Containing Artemether and Lumefantrine for Treatment of P. falciparum","authors":"Vandana Chaudhary, S. Hussain, V. Jain, V. Prakash, R. Khar, Sushruti Sharma","doi":"10.9734/BJPR/2017/26483","DOIUrl":"https://doi.org/10.9734/BJPR/2017/26483","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"35 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82234072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Said, Y. Tamimi, Akhtar, A. M. Weli, Suleiman Al-Khanjari, Qassim Al-Riyami
This paper reports in vitro anticancer activity of hexane, chloroform, ethyl acetate, butanol and water extracts obtained from twelve (12) medicinal plants including Aloe dhufarensis, Calotropis procera, Juniperus servaschanica, Lawsonia inermis, Maytenus dhofarensis, Moringa peregrina, Polygala senensis, Punica granatum, Rhazya stricta, Solanum incanum, Teucrium mascatense. and Zataria multiflora collected from Oman. Crude ethanol extracts prepared by maceration of plant materials in ethanol were Kupchan partitioned to give hexane, chloroform, ethyl acetate, butanol and aqueous fractions. Cytotoxicities of the prepared fractions were measured by Alamar blue assay against ovarian cancer cell line (MCAS) and breast cancer cell line (MDA MB231). Thirteen extracts from five plants C. procera, J. servaschanica, M. dhofarensis, S. incanum and Original Research Article Said et al.; BJPR, 15(5): 1-8, 2017; Article no.BJPR.32459 2 T. mascatense were found active against MCAS; hexane extract from J. servaschanica was the most active followed by chloroform extract from leaves of S. incanum (IC50 = 8.50 and 10.90 μg/ml, respectively). Furthermore, nine extracts from these plants except C. procera inhibited the growth of MDA MB321; hexane extract from J. servaschanica was again the most active followed by butanol extract of S. incanum. (IC50 = 11.4 and 19.44 μg/ml, respectively). Ethnobotanical and ethnopharmacological information on flora growing in this intemperate, hot climate region could provide new chemical entities for development of new and more potent cancer chemotherapeutics.
{"title":"In vitro Anticancer Activity of Selected Medicinal Plants from Oman","authors":"S. Said, Y. Tamimi, Akhtar, A. M. Weli, Suleiman Al-Khanjari, Qassim Al-Riyami","doi":"10.9734/BJPR/2017/32459","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32459","url":null,"abstract":"This paper reports in vitro anticancer activity of hexane, chloroform, ethyl acetate, butanol and water extracts obtained from twelve (12) medicinal plants including Aloe dhufarensis, Calotropis procera, Juniperus servaschanica, Lawsonia inermis, Maytenus dhofarensis, Moringa peregrina, Polygala senensis, Punica granatum, Rhazya stricta, Solanum incanum, Teucrium mascatense. and Zataria multiflora collected from Oman. Crude ethanol extracts prepared by maceration of plant materials in ethanol were Kupchan partitioned to give hexane, chloroform, ethyl acetate, butanol and aqueous fractions. Cytotoxicities of the prepared fractions were measured by Alamar blue assay against ovarian cancer cell line (MCAS) and breast cancer cell line (MDA MB231). Thirteen extracts from five plants C. procera, J. servaschanica, M. dhofarensis, S. incanum and Original Research Article Said et al.; BJPR, 15(5): 1-8, 2017; Article no.BJPR.32459 2 T. mascatense were found active against MCAS; hexane extract from J. servaschanica was the most active followed by chloroform extract from leaves of S. incanum (IC50 = 8.50 and 10.90 μg/ml, respectively). Furthermore, nine extracts from these plants except C. procera inhibited the growth of MDA MB321; hexane extract from J. servaschanica was again the most active followed by butanol extract of S. incanum. (IC50 = 11.4 and 19.44 μg/ml, respectively). Ethnobotanical and ethnopharmacological information on flora growing in this intemperate, hot climate region could provide new chemical entities for development of new and more potent cancer chemotherapeutics.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"89 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84223155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Venkatachalam, M. Harsha, M. Pooja, M. Paranjothy, R. Kumar
{"title":"Enhanced bio-adhesion and sustained delivery of Clotrimazole encapsulated solid lipid nanoparticles loaded in hyaluronic acid gel as anti-fungal therapy","authors":"S. Venkatachalam, M. Harsha, M. Pooja, M. Paranjothy, R. Kumar","doi":"10.9734/BJPR/2017/34063","DOIUrl":"https://doi.org/10.9734/BJPR/2017/34063","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"3 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89800178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Karaveli, N. Ozturk, A. S. Kavakli, G. Çakmak, A. A. Onuk, K. İnanoğlu, B. Karsli
Osteogenesis imperfecta is a rare genetic disorder and a collagen tissue disease for which preoperative preparation and intra-operative anesthesia management must be performed with great care on patients. An operation was planned for a 5-year old female patient with Type I osteogenesis imperfecta due to a right femoral fracture. Her medical history showed that she had been operated due to a left femoral fracture 5 months ago under sevoflurane inhalation anesthesia without any complications. On her physical examination, she was observed to be a short child with growth deficiency, kyphoscoliosis, and bone and shape deformities on her extremities. Her modified Mallampati score was III and neck extension was limited. Preoperative echocardiography, complete blood cell count, coagulation profile, and biochemical values were found in normal limits. She was taken into the Case Study Karaveli et al.; BJPR, 15(5): 1-5, 2017; Article no.BJPR.31703 2 operation theatre and monitorized. Pressure points were supported by silicon peds. Vascular access could not be established at first because of her agitation, and then it was achieved after the patient’s anesthesia induction was performed with sevoflurane. Her neck was kept stable and laryngeal mask was placed in the mouth in the first intervention. Anesthesia was provided through 50% O2 + 50% air and 2% sevoflurane. At the end of the operation that took 90 min, the patient was extubated unevenBtfully, and taken to the recovery room. Main anesthetic problems in patients with osteogenesis imperfecta are the difficulties in maintaining the airway management and malign hyperthermia. We used sevoflurane both at the induction and at the maintenance of anaesthesia due to the difficult vascular access of the patient, and we did not encounter any problems. Inhalation anesthesia such as sevoflurane as well as TIVA could be used for the anesthesia for the patients with osteogenesis imperfecta. Great care must be given because of difficult airway in such patients, and necessary precautions must be taken. Laryngeal mask airway could be preferred in order to secure the airway and avoid traumatic complications.
{"title":"Anesthesia Management in Rare Case: Osteogenesis Imperfecta","authors":"A. Karaveli, N. Ozturk, A. S. Kavakli, G. Çakmak, A. A. Onuk, K. İnanoğlu, B. Karsli","doi":"10.9734/BJPR/2017/31703","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31703","url":null,"abstract":"Osteogenesis imperfecta is a rare genetic disorder and a collagen tissue disease for which preoperative preparation and intra-operative anesthesia management must be performed with great care on patients. An operation was planned for a 5-year old female patient with Type I osteogenesis imperfecta due to a right femoral fracture. Her medical history showed that she had been operated due to a left femoral fracture 5 months ago under sevoflurane inhalation anesthesia without any complications. On her physical examination, she was observed to be a short child with growth deficiency, kyphoscoliosis, and bone and shape deformities on her extremities. Her modified Mallampati score was III and neck extension was limited. Preoperative echocardiography, complete blood cell count, coagulation profile, and biochemical values were found in normal limits. She was taken into the Case Study Karaveli et al.; BJPR, 15(5): 1-5, 2017; Article no.BJPR.31703 2 operation theatre and monitorized. Pressure points were supported by silicon peds. Vascular access could not be established at first because of her agitation, and then it was achieved after the patient’s anesthesia induction was performed with sevoflurane. Her neck was kept stable and laryngeal mask was placed in the mouth in the first intervention. Anesthesia was provided through 50% O2 + 50% air and 2% sevoflurane. At the end of the operation that took 90 min, the patient was extubated unevenBtfully, and taken to the recovery room. Main anesthetic problems in patients with osteogenesis imperfecta are the difficulties in maintaining the airway management and malign hyperthermia. We used sevoflurane both at the induction and at the maintenance of anaesthesia due to the difficult vascular access of the patient, and we did not encounter any problems. Inhalation anesthesia such as sevoflurane as well as TIVA could be used for the anesthesia for the patients with osteogenesis imperfecta. Great care must be given because of difficult airway in such patients, and necessary precautions must be taken. Laryngeal mask airway could be preferred in order to secure the airway and avoid traumatic complications.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"56 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89826201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Gholami, S. Khabnadideh, Y. Ghasemi, B. Mirjalili, Roozbeh Shahmoradi, L. Zamani
{"title":"TiCl4/nano-sawdust as an Efficient Biocatalyst for the Synthesis of Highly Substituted Dihydro- 2-oxopyrroles as Antimicrobial Agents","authors":"A. Gholami, S. Khabnadideh, Y. Ghasemi, B. Mirjalili, Roozbeh Shahmoradi, L. Zamani","doi":"10.9734/BJPR/2017/33030","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33030","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"3 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91053767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Study of Antioxidant and Anticancer Activity of Thuja orientalis Growing in Egypt and Saudi Arabia","authors":"Eman Ramadan Elsharkawy, H. Al-Johar, A. Donia","doi":"10.9734/BJPR/2017/32387","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32387","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"40 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88894316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient Controlled-epidural Analgesia with or without a Background Infusion for Labour Analgesia","authors":"Figen Önder, N. Kayacan, B. Karsli, Z. Bigat","doi":"10.9734/BJPR/2017/31717","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31717","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"78 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89044336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bersama abyssinica Fresen. (Melianthaceae): Antifungal Activity on Aflatoxin B1-producing Mold","authors":"K. Bene, A. Kra, K. Konan, G. Zirihi","doi":"10.9734/BJPR/2017/31695","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31695","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"9 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76352355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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