Sajjad Ali, S. Raza, H. Riaz, Mobasher Butt, H. Saeed, Z. Saleem, T. Khan, M. Ahmad
{"title":"A Demographical Assessment of Different Insulin Regimens in Non-insulin Dependent Diabetics","authors":"Sajjad Ali, S. Raza, H. Riaz, Mobasher Butt, H. Saeed, Z. Saleem, T. Khan, M. Ahmad","doi":"10.9734/BJPR/2017/33437","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33437","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"8 6","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91514727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammadreza Amirsadri, Farimah Rahimi, S. Sharifnia, Niloofar Zehtab
{"title":"Evaluation of Effect of Insurance Coverage on Sale Volume and Price of Entered Drugs in Insurance List in 2012 in Iran","authors":"Mohammadreza Amirsadri, Farimah Rahimi, S. Sharifnia, Niloofar Zehtab","doi":"10.9734/BJPR/2017/31882","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31882","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"48 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88049289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saiqa Ishtiaq, T. Ali, B. Ahmad, Fareeha Anwar, Muhammad S K Afridi, Humera Shaheen
Amaranthus graecizans subsp. silvestris (AMGRS) has traditionally been used a folk medicine in the treatment of inflammation, gonorrhea and piles without scientific evidence. Therefore, methanolic (MeOH) extract of AMGRS was studied for anti-nociceptive, anti-inflammatory and enzymatic inhibition activities in addition to phytochemical screening to ascertain the realism of the folk claims. Anti-nociceptive activity was screened by hot plate test, tail immersion test and acetic acid-induced abdominal writhing in mice with different doses of MeOH extract of AMGRS i.e. 100, 300 and 600 mg/kg. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema model in rats with different doses of MeOH extract of AMGRS i.e. 100, 300 and 600 mg/kg. While, anticholinesterase and protease inhibition was carried to screen MeOH extract for its relevant therapeutic uses. Hot plate technique and tail immersion method demonstrated dose related antinociceptive response starting from 300 mg/kg to maximum effect seen at 600 mg/kg Original Research Article Ishtiaq et al.; BJPR, 15(3): 1-11, 2017; Article no.BJPR.31698 2 dose. Acetic acid induced writing produced 47% pain protection during 1 phase (0-15 minutes) at 600 mg/kg dose. Likewise, carrageenan induced rat paw edema test showed 42% reduction in edema at 4 h after oral administration of dose (600 mg/kg). The MeOH extract showed mild anticholinesterase inhibition (24.29±0.57) while exhibited significant protease inhibition activity (60.52±0.18). The present investigation suggests that this plant possesses substantial antinociceptive, anti-inflammatory and protease inhibition activities.
{"title":"Phytochemical and Biological Evaluations of Methanolic Extract of Amaranthus graecizans subsp. silvestris (Vill.) Brenan","authors":"Saiqa Ishtiaq, T. Ali, B. Ahmad, Fareeha Anwar, Muhammad S K Afridi, Humera Shaheen","doi":"10.9734/BJPR/2017/31698","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31698","url":null,"abstract":"Amaranthus graecizans subsp. silvestris (AMGRS) has traditionally been used a folk medicine in the treatment of inflammation, gonorrhea and piles without scientific evidence. Therefore, methanolic (MeOH) extract of AMGRS was studied for anti-nociceptive, anti-inflammatory and enzymatic inhibition activities in addition to phytochemical screening to ascertain the realism of the folk claims. Anti-nociceptive activity was screened by hot plate test, tail immersion test and acetic acid-induced abdominal writhing in mice with different doses of MeOH extract of AMGRS i.e. 100, 300 and 600 mg/kg. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema model in rats with different doses of MeOH extract of AMGRS i.e. 100, 300 and 600 mg/kg. While, anticholinesterase and protease inhibition was carried to screen MeOH extract for its relevant therapeutic uses. Hot plate technique and tail immersion method demonstrated dose related antinociceptive response starting from 300 mg/kg to maximum effect seen at 600 mg/kg Original Research Article Ishtiaq et al.; BJPR, 15(3): 1-11, 2017; Article no.BJPR.31698 2 dose. Acetic acid induced writing produced 47% pain protection during 1 phase (0-15 minutes) at 600 mg/kg dose. Likewise, carrageenan induced rat paw edema test showed 42% reduction in edema at 4 h after oral administration of dose (600 mg/kg). The MeOH extract showed mild anticholinesterase inhibition (24.29±0.57) while exhibited significant protease inhibition activity (60.52±0.18). The present investigation suggests that this plant possesses substantial antinociceptive, anti-inflammatory and protease inhibition activities.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"8 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82505934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chanhyun Park, Min Sung, S. Kim, Denise I. Pinal, R. Balkrishnan, Jongwha Chang
{"title":"Healthcare Costs of Pediatric Acne in the Medicaid Population: A Retrospective Analysis","authors":"Chanhyun Park, Min Sung, S. Kim, Denise I. Pinal, R. Balkrishnan, Jongwha Chang","doi":"10.9734/BJPR/2017/33274","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33274","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"11 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83636078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thermodynamic Analysis for Adsorption of Amoxicillin onto Magnetic Carbon Nanotubes","authors":"D. Balarak, F. Mostafapour, Ali Joghtaei","doi":"10.9734/BJPR/2017/33212","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33212","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"59 25 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83660586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Mushtaq, Shehla Rehmat, M. Jamil, A. Bashir, Qurat Ul-ain, H. Anwar, Sarah Rashid
{"title":"Evaluation of Hepatoprotective and Hepatotoxic Activities of Root Extracts of Cyperus pertenuis in Rats","authors":"A. Mushtaq, Shehla Rehmat, M. Jamil, A. Bashir, Qurat Ul-ain, H. Anwar, Sarah Rashid","doi":"10.9734/bjpr/2017/32270","DOIUrl":"https://doi.org/10.9734/bjpr/2017/32270","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"47 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88988077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. C. Garms, F. Borges, R. E. Santos, K. Nigoghossian, M. C. R. Miranda, I. Miranda, P. Daltro, S. Scarpari, R. J. Giagio, N. Barros, K. M. Alarcón, Bruno de Camargo Drago, J. L. P. Gemeinder, Bruno Oliveira, Valéria M. G. Nascimento, A. Loffredo, R. Herculano
{"title":"Characterization and Microbiological Application of Ciprofloxacin Loaded in Natural Rubber Latex Membranes","authors":"B. C. Garms, F. Borges, R. E. Santos, K. Nigoghossian, M. C. R. Miranda, I. Miranda, P. Daltro, S. Scarpari, R. J. Giagio, N. Barros, K. M. Alarcón, Bruno de Camargo Drago, J. L. P. Gemeinder, Bruno Oliveira, Valéria M. G. Nascimento, A. Loffredo, R. Herculano","doi":"10.9734/BJPR/2017/31614","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31614","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"2 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89380666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plants in Respiratory Disorders I- Anti-asthmatics, A Review","authors":"S. Adesina, I. Johnny, G. Olayiwola","doi":"10.9734/BJPR/2017/32973","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32973","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"30 1","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87828291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Q. Alabi, R. Akomolafe, O. Olukiran, A. Nafiu, Joseph G Omole, Adebukola Adefisayo, A. Oladele
This study determined the effects of kolaviron on the hematological and biochemical parameters of rats. The aim was to ascertain if its consumption has deleterious effects on these parameters. Forty adult male Wistar rats divided into four groups of ten animals each were used. The control group received 2 ml/kg propylene glycol only. Kolaviron (KV) was administered at 100, 200 and 400 mg/kg body weight respectively to the experimental groups via oral route for 28 days. At the end of the study period, five rats were sacrificed under ketamine hydrochloride and the other 5 rats Original Research Article Alabi et al.; BJPR, 16(3): 1-14, 2017; Article no.BJPR.33517 2 were allowed to recover for 2 weeks. Hematological analysis was carried out, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin and glucose were assayed from the plasma while the liver tissue was used for histopathological examination. Compared with the control group, white blood cell (WBC) and lymphocyte, red blood cells (RBCs) counts, hematocrit (HCT) and hemoglobin (Hb) concentrations were significantly higher in groups treated with 100 and 200 mg/kg b.w of KV. However, plasma AST, ALT, ALP activities and bilirubin in 100 and 200 mg/kg KV were not significant different from that of the control. There was a significantly lower plasma glucose level in all KV treated groups when compared with the control. However, KV at 400 mg/kg had a significantly higher RBCs count with a significantly lower Hb, mean corpuscular hemoglobin concentration (MCHC) and platelet count. The plasma AST, ALT activities and bilirubin level were also higher in 400 mg/kg b.w KV when compared with the control, but plasma ALP remain unchanged. At 400 mg/kg b.w KV, histological examination of the liver tissue showed sign of portal cellular infiltration, periportal congestion and hydropic degeneration of hepatocytes in the liver, but restored toward normal after 2 weeks recovery period. This study confirmed that KV at 100 and 200 mg/kg b.w improve hematological indices with hypoglycemic and immune boosting effects in rats. However, KV at higher dosage (400 mg/kg b.w) has tendency to have deleterious effects on the liver and blood.
{"title":"Assessment of Haematological and Biochemical Effects of Kolaviron in Male Wistar Rats","authors":"Q. Alabi, R. Akomolafe, O. Olukiran, A. Nafiu, Joseph G Omole, Adebukola Adefisayo, A. Oladele","doi":"10.9734/BJPR/2017/33517","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33517","url":null,"abstract":"This study determined the effects of kolaviron on the hematological and biochemical parameters of rats. The aim was to ascertain if its consumption has deleterious effects on these parameters. Forty adult male Wistar rats divided into four groups of ten animals each were used. The control group received 2 ml/kg propylene glycol only. Kolaviron (KV) was administered at 100, 200 and 400 mg/kg body weight respectively to the experimental groups via oral route for 28 days. At the end of the study period, five rats were sacrificed under ketamine hydrochloride and the other 5 rats Original Research Article Alabi et al.; BJPR, 16(3): 1-14, 2017; Article no.BJPR.33517 2 were allowed to recover for 2 weeks. Hematological analysis was carried out, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin and glucose were assayed from the plasma while the liver tissue was used for histopathological examination. Compared with the control group, white blood cell (WBC) and lymphocyte, red blood cells (RBCs) counts, hematocrit (HCT) and hemoglobin (Hb) concentrations were significantly higher in groups treated with 100 and 200 mg/kg b.w of KV. However, plasma AST, ALT, ALP activities and bilirubin in 100 and 200 mg/kg KV were not significant different from that of the control. There was a significantly lower plasma glucose level in all KV treated groups when compared with the control. However, KV at 400 mg/kg had a significantly higher RBCs count with a significantly lower Hb, mean corpuscular hemoglobin concentration (MCHC) and platelet count. The plasma AST, ALT activities and bilirubin level were also higher in 400 mg/kg b.w KV when compared with the control, but plasma ALP remain unchanged. At 400 mg/kg b.w KV, histological examination of the liver tissue showed sign of portal cellular infiltration, periportal congestion and hydropic degeneration of hepatocytes in the liver, but restored toward normal after 2 weeks recovery period. This study confirmed that KV at 100 and 200 mg/kg b.w improve hematological indices with hypoglycemic and immune boosting effects in rats. However, KV at higher dosage (400 mg/kg b.w) has tendency to have deleterious effects on the liver and blood.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"102 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79409168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Barari, Z. Abedian, A. Asadi, F. Elmi, M. M. Elmi
{"title":"Anti-proliferative Effect of Chickpea Extract on Hela, MCF-7, Saos and Fibroblast Cell Lines","authors":"L. Barari, Z. Abedian, A. Asadi, F. Elmi, M. M. Elmi","doi":"10.9734/BJPR/2017/30637","DOIUrl":"https://doi.org/10.9734/BJPR/2017/30637","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"44 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79960473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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