Journal of hazardous materials letters最新文献_第3页

Reusable thiophene-based fluorescent sensor for detection of toxic Au³ ⁺ in real samples: Integrated spectroscopic and computational insight 用于检测真实样品中有毒Au³ ⁺的可重复使用的噻吩基荧光传感器：集成光谱和计算洞察力

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-04-23 DOI: 10.1016/j.hazl.2025.100152

Hasher Irshad, Katrine Qvortrup

Gold exhibits fascinating photophysical and photochemical properties, making it valuable in various applications, including catalysis, fluorescent porous materials, fluorophores and medicine. However, high concentrations (0.075 and 0.006 mg/L) in fresh water are toxic, posing a threat to human health. Therefore, convenient chemical sensors are required for Au³⁺ monitoring. In this study, we present a novel carbazole-extended thiophene-containing electron rich organic compound (CT) and studied its interaction with Au³⁺ along with a range of sulphur containing small organic molecules through fluorescence, UV Vis. and NMR spectroscopy. Strong interaction between CT and Au³⁺ was further evaluated via SEM and DFT studies. Mechanism of interaction between CT and Au³⁺ was proposed to be chelation enhancement quenching effect (CHEQ) and the strong interaction explained based on the hard and soft acid and base (HSAB) theory. Interference studies showed highly selective interaction of CT with Au³⁺ in diverse conditions which makes CT a very promising fluorescent sensor. Therefore, real samples were also analyzed for the trace detection of Au³⁺ and ultra-fast, reversible and quantitative detection of Au³⁺ was achieved.

金表现出迷人的光物理和光化学性质，使其在各种应用中具有价值，包括催化，荧光多孔材料，荧光团和医学。然而，淡水中的高浓度（0.075和0.006 毫克/升）是有毒的，对人类健康构成威胁。因此，需要方便的化学传感器来监测Au3+。在这项研究中，我们提出了一种新的含咔唑扩展噻吩的富电子有机化合物（CT），并通过荧光，紫外可见和核磁共振光谱研究了它与Au3+以及一系列含硫小有机分子的相互作用。CT与Au3+之间的强相互作用通过SEM和DFT进一步评估。提出了CT与Au3+相互作用的机理为螯合增强猝灭效应（CHEQ），并根据软硬酸碱（HSAB）理论解释了强相互作用。干扰研究表明，CT与Au3+在不同条件下具有高度选择性的相互作用，使CT成为一种非常有前途的荧光传感器。因此，还对真实样品进行了Au3+的痕量检测，实现了Au3+的超快速、可逆、定量检测。

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引用次数: 0

Aftermath of a major firefighting foam spill in Brunswick, Maine: Spatiotemporal dynamics of per- and polyfluoroalkyl substances in the downstream surface waters 缅因州不伦瑞克一次重大消防泡沫泄漏的后果：下游地表水中全氟烷基和多氟烷基物质的时空动态

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-04-08 DOI: 10.1016/j.hazl.2025.100150

Macy Hannan , Fatih Evrendilek , Daniel Leclair , Manisha Choudhary , Kenneth Mensah , Christoph Aeppli , Arjun K. Venkatesan , Onur G. Apul

On August 19, 2024, 5,500 L of per- and polyfluoroalkyl substances (PFAS)-based aqueous film-forming foam (AFFF) spilled into the watershed near Brunswick Executive Airport in Maine, USA. This study investigates the immediate impact of the largest PFAS spill in the state's history on nearby aquatic ecosystems. Over 11 days, PFAS were sampled from nine surface waters, detecting 18 PFAS, predominantly perfluorooctanesulfonic acid (PFOS). A significant reduction in PFAS levels occurred within days due to clean-up efforts and natural attenuation (e.g., dilution, adsorption, and aerosolization), in addition to downstream transport. Kruskal-Wallis and Steel-Dwass tests revealed significant spatial variability in PFAS, with PFOS, perfluorohexanesulfonic acid, and perfluoroalkyloctanoic acid remaining elevated near the spill but declined by 99.9 % at the Harpswell Cove estuary 3.2 km south of the spill. The rapid PFAS spread poses risks to the downstream environments. This study provides insights into post-spill PFAS dynamics and highlights the urgency of minimizing PFAS-based AFFF use and spills, and further research into long-term ecosystem and human health risks associated with PFAS contamination.

Synopsis

The aftermath of a major AFFF spill was analyzed to provide insights into immediate spatiotemporal distribution of PFAS.

2024年8月19日，5,500 L基于全氟烷基和多氟烷基物质（PFAS）的水性成膜泡沫（AFFF）泄漏到美国缅因州不伦瑞克行政机场附近的分水岭。这项研究调查了该州历史上最大的PFAS泄漏对附近水生生态系统的直接影响。在11天的时间里，从9个地表水中取样了全氟辛烷磺酸，检测到18种全氟辛烷磺酸，主要是全氟辛烷磺酸。由于清理工作和自然衰减（如稀释、吸附和雾化）以及下游运输，PFAS水平在几天内显著降低。Kruskal-Wallis和钢- dwass试验显示，全氟辛烷磺酸、全氟六磺酸和全氟烷基辛酸在泄漏点附近仍处于升高状态，但在泄漏点以南3.2 公里的Harpswell湾河口下降了99.9% %。PFAS的快速扩散给下游环境带来了风险。该研究提供了对泄漏后PFAS动态的见解，并强调了减少PFAS的AFFF使用和泄漏的紧迫性，以及对PFAS污染相关的长期生态系统和人类健康风险的进一步研究。摘要分析了AFFF重大泄漏的后果，以提供对PFAS即时时空分布的见解。

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引用次数: 0

Rational design of CYP120A1 variants and eco-friendly alternatives for enhanced bioremediation of sulfonamide antibiotics 合理设计CYP120A1变异体及生态友好型替代物以增强磺胺类抗生素的生物修复

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-03-26 DOI: 10.1016/j.hazl.2025.100151

Miaomiao Li , Xu Guan , Xiaoxia Yu , Ledong Zhu , Ruiming Zhang , Qingzhu Zhang , Wenxing Wang , Qiao Wang

Bioremediation mediated by cytochrome P450 enzymes represents an effective strategy for the removal of Sulfonamides (SAs). However, the inherent limitations in the thermostability and catalytic activity of wild-type enzymes result in suboptimal remediation efficiency. Therefore, the development of highly efficient degradative enzymes is crucial for mitigating SAs pollution. Additionally, identifying environmentally friendly alternatives with lower toxicity is beneficial for source control of SAs. This work adopts an integrated strategy that combines bioremediation and source control. Utilizing multiple computational strategies, we rationally designed and screened novel high-efficiency enzyme variants of CYP120A1 specifically targeting SAs degradation, and concurrently evaluated the molecular properties of pollutants to design new green alternatives. This study successfully identified 18 single-mutation enzyme candidates with enhanced thermostability and catalytic activity. Furthermore, we designed three green alternatives, SDZ-13, SDZ-19, and SDZ-27, which exhibit lower toxicity and significantly improved binding affinity with the degradative enzymes. However, accurate and rapid identification of mutation sites and practical application of eco-friendly molecular design remain significant challenges for future research. This work provides theoretical support for the development of efficient degradative enzymes and the design of sustainable alternative compounds, contributing to the advancement of emerging pollutants pollution control strategies.

细胞色素P450酶介导的生物修复是去除磺胺类化合物的有效方法。然而，野生型酶在热稳定性和催化活性方面的固有局限性导致修复效率不理想。因此，开发高效的降解酶是缓解砷污染的关键。此外，寻找毒性较低的环境友好型替代品有助于控制砷的来源。这项工作采用了结合生物修复和源头控制的综合策略。利用多种计算策略，合理设计和筛选针对SAs降解的CYP120A1新型高效酶变体，同时评估污染物的分子特性，设计新的绿色替代品。本研究成功鉴定出18种具有较强热稳定性和催化活性的单突变候选酶。此外，我们设计了三种绿色替代品SDZ-13、SDZ-19和SDZ-27，它们具有较低的毒性，并显著提高了与降解酶的结合亲和力。然而，准确、快速地识别突变位点和生态分子设计的实际应用仍然是未来研究的重大挑战。这项工作为高效降解酶的开发和可持续替代化合物的设计提供了理论支持，有助于推进新兴污染物的污染控制策略。

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引用次数: 0

Atmospheric microplastics emission from municipal solid waste incineration power plant: Field evidence and characterizations 城市固体垃圾焚烧发电厂的大气微塑料排放：现场证据和特征

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-03-14 DOI: 10.1016/j.hazl.2025.100149

Ting Su , Huasheng Wang , Xiangyu Gu , Shuo Liu , Yusu Xiong , Shuang Deng , Songgeng Li

Microplastics have been discovered in the solid residuals from municipal solid waste (MSW) incineration plant, posing potential risks to the surrounding environments. However, there exists a lack of evidence on the presence and characterizations of atmospheric microplastic emission from MSW incineration, which is considered more hazardous due to size reduction. Hence, we collected particles from flue gas emitted by a circulating fluidized bed incinerator, to investigate the morphology, chemical structure, and emission abundance of microplastics. Further, particles from different stream locations were collected to identify the effects of air pollution control devices on the microplastic abundance and chemical structures. Results indicate the predominant length of the microplastics in the flue gas ranged from 10 to 40 μm at different locations. The major polymer types of microplastics were polyvinyl chloride and polyacrylamide, resulting from inherent Cl elements and selective non-catalytic reduction in MSW, respectively. Based on the field data, the atmospheric microplastic emission was estimated at 2.1 × 10¹² pieces/yr, turned out to be a pivotal contributor to the atmospheric microplastics. Notably, the unique microplastic chemical properties pose a higher threat to human health than conventional plastics. Our work prioritizes an alternative source of microplastic emissions and calls for further research endeavors.

在城市固体垃圾焚烧厂的固体残余物中发现了微塑料，对周围环境构成潜在威胁。然而，关于城市生活垃圾焚烧产生的大气微塑料的存在和特征缺乏证据，由于尺寸减小，人们认为微塑料的危害更大。因此，我们从循环流化床焚烧炉排放的烟气中收集颗粒，研究微塑料的形态、化学结构和排放丰度。此外，收集了来自不同河流位置的颗粒，以确定空气污染控制装置对微塑料丰度和化学结构的影响。结果表明，烟气中微塑料在不同位置的优势长度在10 ~ 40 μm之间。微塑料的主要聚合物类型是聚氯乙烯和聚丙烯酰胺，它们分别是由城市生活垃圾中固有的Cl元素和选择性非催化还原产生的。根据现场数据估算，大气微塑料排放量为2.1 × 1012片/年，是大气微塑料的关键贡献者。值得注意的是，微塑料独特的化学性质对人类健康的威胁比传统塑料更大。我们的工作优先考虑微塑料排放的替代来源，并呼吁进一步的研究努力。

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引用次数: 0

Recovery of nitrate and fluoride salts from stainless steel pickling wastewater with flow-electrode capacitive deionization 流动电极电容去离子法回收不锈钢酸洗废水中的硝酸盐和氟化物

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-02-20 DOI: 10.1016/j.hazl.2025.100148

Niklas Köller , Dustin Roedder , Christian J. Linnartz , Mark Enders , Florian Morell , Patrick Altmeier , Matthias Wessling

Flow-electrode Capacitive Deionization (FCDI) is an innovative method for practical salt removal and recycling applications. Here, we report that FCDI facilitates the recovery of nitrate and fluoride salts from brines produced during the wastewater treatment process in a stainless steel pickling line. Laboratory-scale experiments with synthetic wastewaters were used to evaluate the influence of (a) the membrane thickness, (b) feed flow rates, and (c) applied voltage on the outlet concentrations and the average salt transfer rate. In continuous single-pass experiments, the flow rates of diluate and concentrate have the greatest influence on the resulting outlet concentrations in the FCDI process as they directly influence the residence time. The operating voltage of the FCDI process can be varied to increase the ratio of fluoride over nitrate for recycling.

流动电极电容去离子（FCDI）是一种创新的实际脱盐和回收应用方法。在这里，我们报道FCDI有助于从不锈钢酸洗线废水处理过程中产生的盐水中回收硝酸盐和氟化物盐。采用实验室规模的合成废水实验来评估(a)膜厚度、(b)进料流量和(c)施加电压对出口浓度和平均盐转移速率的影响。在连续的单道次实验中，稀释和浓缩的流量对FCDI过程的出口浓度影响最大，因为它们直接影响停留时间。可以改变FCDI工艺的工作电压，以提高氟化物与硝酸盐的比率，以便回收利用。

引用次数: 0

First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio) 四种常见有机紫外线过滤器对斑马鱼幼鱼和成年斑马鱼肾毒性电位的初步比较

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-02-19 DOI: 10.1016/j.hazl.2025.100143

Ba Reum Kwon , Gowoon Lee , Inae Lee , Ah-Reum Jo , Jeonghwan Lee , Na-Youn Park , Younglim Kho , Jung Pyo Lee , Kyungho Choi

To protect against UV light, organic UV filters (UVFs) are widely used in sunscreen and various consumer products. Concerns regarding the potential health impacts of UVFs have been raised, however, information is mostly limited to their endocrine disruptions. The present study aims to investigate nephrotoxic potentials of four major organic UVFs, i.e., avobenzone (AVB), benzophenone-3 (BP-3), octocrylene (OC), and octyl methoxycinnamate (OMC), using a zebrafish model at different life stages. Test UVFs were applied during early (0–30 days post-fertilization (dpf)), and adult life stage (> 6 months old, 21 d exposure), and investigated for alterations in gene expression and/or kidney function. In juvenile fish (30 dpf), early life stage exposure to BP-3 and OMC caused significant induction of proteinuria. Moreover, regardless of life stage, key genes (wt1a, podocin, nephrin, cdh17, sim1a, and kim-1) responsible for kidney structure and function showed transcriptional alterations that support nephrotoxic potentials of the test UVFs. Our results demonstrate that exposure to widely used organic UVFs could impair normal biological processes for maintaining kidney health during both life stages. Considering the widespread use of organic UVFs among the general human population, the implication of this nephrotoxic potential warrants further investigation.

为了防止紫外线，有机紫外线过滤器（UVFs）广泛用于防晒霜和各种消费产品。人们对紫外线辐射可能对健康造成的影响表示关注，然而，信息大多局限于其对内分泌的干扰。本研究旨在研究四种主要有机紫外线，即阿伏苯酮（AVB）、二苯甲酮-3 （BP-3）、八烯丙烯（OC）和甲氧基肉桂酸辛酯（OMC），在不同生命阶段的斑马鱼模型中的肾毒性。试验UVFs应用于早期（受精后0-30天（dpf））和成年期(>；6个月大，暴露21天)，并研究基因表达和/或肾功能的改变。在幼鱼（30 dpf）中，生命早期暴露于BP-3和OMC可显著诱导蛋白尿。此外，无论生命阶段如何，负责肾脏结构和功能的关键基因（wt1a、podocin、nephrin、cdh17、sim1a和kim-1）显示出转录改变，这支持了测试UVFs的肾毒性潜力。我们的研究结果表明，暴露于广泛使用的有机紫外线可能会损害在生命的两个阶段维持肾脏健康的正常生物过程。考虑到有机紫外线在普通人群中的广泛使用，这种潜在的肾毒性值得进一步研究。

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引用次数: 0

Exploring the impact of copper oxide nanoparticles on the biocontrol activity and plant growth promotion of Trichoderma asperellum 探讨氧化铜纳米颗粒对曲霉木霉生防活性及促进植株生长的影响

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-02-19 DOI: 10.1016/j.hazl.2025.100147

Claudia A. Ramírez-Valdespino , Marlyn Morales-García , Guillermo Herrera-Pérez , Yordan J. Romero-Contreras , Enrique García-Mireles , Joan Salas-Leiva , Susana González-Chávez , Socorro Tarango-Rivero , Erasmo Orrantia-Borunda

Agriculture is constantly in the search for new alternatives to control phytopathogens and improvement of plant growth. One of its main strategies is the use of biocontrollers, among them, Trichoderma genus stand out for their versatility and broad spectrum phytopatogenic fungi attacked. On the other hand, nanotechnology is positioning itself as an alternative to the use of agrochemicals, especially metal oxide nanoparticles, including ZnO, TiO₂ and CuO. Recently, it has been seen that when Trichoderma is put in contact with nanoparticles, it increases its biocontrol and biostimulant activity. Therefore, in this work we performed the characterization of a T. asperellum strain, which was capable to grow in different concentrations of CuO nanoparticles, obtaining that, at 200 ppm, Trichoderma showed no changes in growth and no apparent stress. Moreover, the strain developed a higher biocontrol activity against two Fusarium oxysporum strains, but decreases with F. fujikuroi, as well as changes in the expression of genes associated to biocontrol. Finally, an enhance in alfalfa growth is reported. These results suggest that, at the tested concentrations, CuO-NPs do not interfere with the biocontrol activity of T. asperellum, providing the basis for the development of a bionanoformulation to control F. oxysporum and promotes alfalfa growth.

农业一直在不断寻找新的替代方法来控制植物病原体和改善植物生长。其主要策略之一是使用生物防治剂，其中木霉属以其多功能性和广谱的植物性真菌攻击而突出。另一方面，纳米技术将自己定位为农用化学品的替代品，特别是金属氧化物纳米粒子，包括ZnO、TiO2和CuO。最近，人们发现当木霉与纳米颗粒接触时，它的生物防治和生物刺激素活性增加。因此，在这项工作中，我们对一株能够在不同浓度的CuO纳米颗粒中生长的曲霉菌株进行了表征，结果表明，在200 ppm的浓度下，木霉的生长没有变化，也没有明显的胁迫。此外，该菌株对两种尖孢镰刀菌均有较高的生物防治活性，但对fujikuroi和生物防治相关基因表达的变化均有抑制作用。最后，报道了苜蓿生长的增强。这些结果表明，在测试浓度下，CuO-NPs不会干扰曲霉的生物防治活性，为开发防治尖孢镰刀菌和促进苜蓿生长的生物纳米制剂提供了基础。

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引用次数: 0

Parental BPA exposure disrupts offspring transcriptomic profiles and impairs embryonic lineage specification during zygotic genome activation 父母双酚a暴露破坏后代转录组谱和损害胚胎谱系规范在合子基因组激活

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-02-18 DOI: 10.1016/j.hazl.2025.100146

Yuequn Chen , Kusheng Wu , Wenlong Huang

Bisphenol A (BPA) is an endocrine-disrupting chemical known for its developmental toxicity. However, the impact of BPA on early embryonic development, particularly during zygotic genome activation (ZGA), remains underexplored. In this study, zebrafish embryos at 3.5 and 4.5 hours post-fertilization (hpf) were collected after 7-day parental exposure to 1.0 µM BPA for transcriptome sequencing. Transcriptomic data underwent differential gene expression functional enrichment and gene set enrichment analyses. Public single-cell transcriptome atlases of zebrafish embryos at different developmental stages (3.3, 4, and 4.8 hpf) were obtained to build signature matrices for digital cell type sorting of the bulk transcriptome using the CIBERSORTx algorithm. Results indicated that parental BPA exposure resulted in muted gene expression response, disturbed energy metabolism profile, and increased pro-inflammatory signatures during ZGA. Digital cell type deconvolution revealed altered cell composition, including deeper multilayer and enveloping layer cells and fewer margin cells. Furthermore, reductions in neural progenitor and heart primordium lineages, alongside expansions in primordial germ and mesendodermal lineages, potentially contribute to later-stage developmental abnormalities. This study elucidates the embryotoxic effects of BPA during the ZGA period, shedding light on the developmental perturbations from early-life exposure to this ubiquitous environmental contaminant.

双酚A （BPA）是一种内分泌干扰化学物质，以其发育毒性而闻名。然而，BPA对早期胚胎发育的影响，特别是在合子基因组激活（ZGA）期间，仍未得到充分研究。在本研究中，父母暴露于1.0 µM BPA 7天后，采集受精后3.5和4.5 小时（hpf）的斑马鱼胚胎进行转录组测序。转录组学数据进行了差异基因表达、功能富集和基因集富集分析。获取不同发育阶段（3.3、4和4.8 hpf）的斑马鱼胚胎的公开单细胞转录组图谱，利用CIBERSORTx算法构建标记矩阵，用于批量转录组的数字细胞类型分选。结果表明，父母双酚a暴露导致ZGA期间基因表达反应减弱，能量代谢谱紊乱，促炎特征增加。数字细胞类型反褶积显示细胞组成改变，包括多层和包络层细胞变深，边缘细胞变少。此外，神经祖细胞和心脏原基谱系的减少，以及原始生殖细胞和中胚层谱系的扩张，可能导致后期发育异常。本研究阐明了双酚a在ZGA时期的胚胎毒性作用，揭示了早期暴露于这种普遍存在的环境污染物对发育的干扰。

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引用次数: 0

Pyrethroids have become a barrier to the daily existence of molluscs (Review) 拟除虫菊酯已成为软体动物日常生存的障碍（回顾）

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-02-16 DOI: 10.1016/j.hazl.2025.100144

Raja Saha , Sangita Maiti Dutta

Molluscs are significant aquatic organisms, which serve as bioindicator species. They are crucial for maintaining ecological balance as secondary consumers. Molluscs are threatened by pesticides such as pyrethroid insecticides. Pyrethroids are increasingly utilized to control insects in agriculture and gardening. It contaminates aquatic bodies through rainwater runoff and drainage-sewage systems. The current review will focus on the issue of increasing pyrethroid use and its biological effects on molluscs. Due to their highly lipophilic nature, pyrethroids pose a significant risk to these organisms by affecting their metabolites, producing reactive oxygen species, and influencing neurotransmitter actions. The threats to the molluscs and eventually to the concerned aquatic ecosystem warrant significant discussion and attention.

软体动物是重要的水生生物，是生物指示物种。他们作为次级消费者对维持生态平衡至关重要。软体动物受到杀虫剂的威胁，例如拟除虫菊酯杀虫剂。拟除虫菊酯类杀虫剂越来越多地用于农业和园艺中的昆虫防治。它通过雨水径流和排水污水系统污染水体。目前的审查将侧重于增加使用拟除虫菊酯类杀虫剂的问题及其对软体动物的生物学影响。由于其高度亲脂性，拟除虫菊酯通过影响这些生物的代谢物、产生活性氧和影响神经递质作用，对这些生物构成重大风险。对软体动物和水生生态系统的威胁值得讨论和关注。

引用次数: 0

Toxicological assessment & risk evaluation of pesticides and their mixtures through C. elegans & RISK21: A risk-based approach for sustainable agriculture 通过秀丽隐杆线虫进行农药及其混合物的毒理学评估和风险评估& RISK21：可持续农业的基于风险的方法

IF 6.6 Q1 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials letters

Pub Date : 2025-02-12 DOI: 10.1016/j.hazl.2025.100145

Mariana I. Manetti , M. Laura Migliori , M. Florencia Kronberg , Rosana Rota , Aldana Moya , Eduardo A. Pagano , Daniel H. Calvo , Sandrine Deglin , Michelle Embry , Diego A. Golombek , Eliana R. Munarriz

Pesticides are extensively used in agriculture to protect crops, but their environmental release, particularly as mixtures, raises concerns about effects on non-target organisms and ecosystem health. This study aimed to evaluate the toxicity of five pesticides used extensively on soybean crops - glyphosate, 2,4-D, paraquat, chlorpyrifos, and lambda-cyhalothrin- and their binary mixtures on the nematode Caenorhabditis elegans, a model organism in toxicology. Locomotion and growth assays were conducted to assess acute and chronic effects, and the RISK21 matrix framework was used to convey environmental risks based on the bioassay results combined with surface water monitoring data and modeled exposure estimates. Our results demonstrate significant reductions in locomotion and body length for all tested pesticides, with synergistic effects observed in binary mixtures. However, the risk-based analysis suggests that the estimated environmental concentrations of these pesticides pose minimal ecological risks. In conclusion, our work highlights the novelty of combining C. elegans-based toxicity assays in a risk-based approach to evaluate pesticide mixtures, offering a practical approach for predicting environmental impacts and promoting sustainable agriculture.

农药在农业中广泛用于保护作物，但它们的环境释放，特别是作为混合物，引起了对非目标生物和生态系统健康影响的担忧。本研究旨在评价大豆作物上广泛使用的草甘膦、2,4- d、百草枯、毒死蜱和高效氯氟氰菊酯五种农药及其二元混合物对毒理学模式生物秀丽隐杆线虫的毒性。通过运动和生长试验来评估急性和慢性影响，并使用RISK21矩阵框架来传达基于生物测定结果、地表水监测数据和建模暴露估计的环境风险。我们的研究结果表明，所有被测农药的运动和体长都显著减少，在二元混合物中观察到协同效应。然而，基于风险的分析表明，这些农药的估计环境浓度构成最小的生态风险。总之，我们的工作突出了将基于秀丽隐杆线虫的毒性试验与基于风险的方法相结合来评估农药混合物的新颖性，为预测环境影响和促进可持续农业提供了一种实用的方法。

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引用次数: 0