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Fluorescent Chemosensors for Ion and Molecule Recognition: The Next Chapter 用于离子和分子识别的荧光化学传感器:下一章
Pub Date : 2021-09-16 DOI: 10.3389/fsens.2021.731928
Kai-Cheng Yan, Axel Steinbrueck, A. Sedgwick, T. James
Over the past 30 years fluorescent chemosensors have evolved to incorporate many optical-based modalities and strategies. In this perspective we seek to highlight the current state of the art as well as provide our viewpoint on the most significant future challenges remaining in the area. To underscore current trends in the field and to facilitate understanding of the area, we provide the reader with appropriate contemporary examples. We then conclude with our thoughts on the most probable directions that chemosensor development will take in the not-too-distant future.
在过去的30年里,荧光化学传感器已经发展到包含许多基于光学的模式和策略。从这个角度来看,我们试图强调当前的技术状态,并就该领域未来最重大的挑战提供我们的观点。为了强调该领域的当前趋势并促进对该领域的理解,我们为读者提供了适当的当代例子。然后,我们总结了在不久的将来化学传感器发展的最可能方向。
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引用次数: 7
Nanoparticle-Based FM-MCF LSPR Biosensor With Open Air-Hole 基于纳米颗粒的开放气孔FM-MCF LSPR生物传感器
Pub Date : 2021-09-13 DOI: 10.3389/fsens.2021.751952
Chuanhao Yang, Shiyan Xiao, Qi Wang, Hongxia Zhang, Hui Yu, Dagong Jia
A nanoparticle-based few-mode multi-core fiber (FM-MCF) localized surface plasmon resonance (LSPR) biosensor is proposed and analyzed using the finite element method (FEM). It’s critical to narrow the loss spectrum and improve the coupling efficiency, which makes it have high resolution and high sensitivity. With the aid of open air holes, the gold nanoparticles are easily assembled on the surface of this FM-MCF LSPR biosensor. Through multiple investigations, the performance of the sensor can be improved by properly setting gold nanoparticle configurations, such as radius, positions, shapes, and nanoparticle arrays. The simulation results show that when three circular gold nanoparticles with a radius of 150 nm are placed symmetrically in the open air hole and the angle between adjacent nanoparticles is 5°, the maximum sensitivity of 7,351.6 nm/RIU (LP02y mode na = 1.38) can be obtained in the sensing range of 1.33–1.38, which covers the refractive index (RI) of biological fluids, such as bovine serum albumin (BSA) solution and human Immunoglobulin G.
提出了一种基于纳米粒子的少模多芯光纤(FM-MCF)局域表面等离子体共振(LSPR)生物传感器,并用有限元方法对其进行了分析。缩小损耗谱、提高耦合效率是实现高分辨率、高灵敏度的关键。在开放气孔的帮助下,金纳米颗粒很容易组装在这种FM-MCF LSPR生物传感器的表面。通过多次研究,可以通过适当设置金纳米粒子的配置,如半径、位置、形状和纳米粒子阵列,来提高传感器的性能。仿真结果表明,当3个半径为150 nm的圆形金纳米颗粒对称放置在开放的空气孔中,相邻纳米颗粒之间的夹角为5°时,在1.33 ~ 1.38的传感范围内,可获得最大灵敏度为7351.6 nm/RIU (LP02y模式na = 1.38),该传感范围涵盖了牛血清白蛋白(BSA)溶液和人免疫球蛋白G等生物液体的折射率(RI)。
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引用次数: 0
Antilope, A Portable Low-Cost Sensor System for the Assessment of Indoor and Outdoor Air Pollution Exposure 用于室内和室外空气污染暴露评估的便携式低成本传感器系统Antilope
Pub Date : 2021-09-08 DOI: 10.3389/fsens.2021.679908
F. Lenartz, Marie Dury, B. Bergmans, V. Hutsemekers, V. Broun, Christophe Brose, S. Guichaux
The increasing availability of low-cost sensors and open source projects make it easier than ever for a maker to build his own air quality node. Nonetheless, depending on one’s goal and its related data quality objective, to customize an existing project or to build a specific printed circuit board may still be very useful. In the framework of the Outdoor and Indoor Exposure project, a portable mini-station has been developed, tested and then used in two experiments: exposure assessment and complementary network measurement. The present paper focuses on the description of the equipment that was designed and prototyped, as well as on the tests that were made in the lab and in the field to evaluate its overall performance and that of its different sensors. Finally, we present what we consider to be its main drawbacks and our perspectives for further development and tests.
越来越多的低成本传感器和开源项目使得制造商比以往任何时候都更容易建立自己的空气质量节点。尽管如此,根据一个人的目标及其相关的数据质量目标,定制一个现有的项目或构建一个特定的印刷电路板可能仍然非常有用。在室外和室内暴露项目的框架下,开发了一个便携式迷你站,测试并随后用于两个实验:暴露评估和互补网络测量。本论文着重介绍了所设计和制造的设备,以及在实验室和实地进行的测试,以评估其总体性能及其不同传感器的性能。最后,我们提出了我们认为它的主要缺点,以及我们对进一步开发和测试的看法。
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引用次数: 0
Nutrient Analysis in Arctic Waters Using a Portable Sensing Platform 使用便携式传感平台对北极水域的营养物质进行分析
Pub Date : 2021-09-02 DOI: 10.3389/fsens.2021.711592
Margaret McCaul, P. Magni, S. Jordan, E. McNamara, A. Satta, D. Diamond, A. Ribotti
A portable sensing platform for the detection of nutrients (PO4 3−, NO2 −, NO3 −) in natural waters has been realized through the use of rapid prototyping techniques, colorimetric chemistries, electronics, and LED-based optical detection. The sensing platform is modular in design incorporating interchangeable optical detection units, with a component cost per unit of ca. €300, and small form factor (20 cm × 6 cm x 3.5 cm). Laboratory testing and validation of the platform was performed prior to deployment at the CNR Dirigibile Italia Arctic Research Station, Ny-Aselund (79°N, 12°E). Results obtained showed excellent linear response, with a limit of detection of 0.05 μM (NO2 −, NO3 −), and 0.03 μM (PO4 3−). On the June 22, 2016 a field campaign took place within Kongsfjorden, Ny-Aselund (78.5–79°N, 11.6–12.6°E), during which 55 water samples were acquired using 10 L Niskin bottles on board the MS Teisten research vessel. 23 hydrological casts were also performed using a Seabird 19plus V2 SeaCAT Profiler CTD probe with turbidity and dissolved oxygen sensors. Water samples were subsequently analyzed for PO4 3−, NO2 −, NO3 − at the CNR Dirigibile Italia Arctic Research Station Laboratory using the adaptive sensing platform. Nutrient concentrations were compared to hydrological data to assess the processes that influence the nutrient concentrations within the Fjord. This research highlights the potential use of the adaptive sensing platform in remote locations as a stand-alone platform and/or for the validation of deployable environmental sensor networks.
通过使用快速原型技术、比色化学、电子和基于LED的光学检测,实现了一种用于检测天然水中营养物质(PO4 3−、NO2−、NO3−)的便携式传感平台。传感平台在设计上是模块化的,包括可互换的光学检测单元,每个单元的组件成本约为300欧元,并且外形尺寸较小(20厘米×6厘米×3.5厘米)。该平台的实验室测试和验证在部署前在位于Ny Aselond(79°N,12°E)的CNR Dirigibile Italia北极研究站进行。所获得的结果显示出极好的线性响应,检测限为0.05μM(NO2−、NO3−)和0.03μM(PO4 3−)。2016年6月22日,在Ny Aselond的Kongsfjorden(78.5–79°N,11.6–12.6°E)进行了一次实地考察,期间使用MS Teisten研究船上的10 L Niskin瓶采集了55个水样。还使用带有浊度和溶解氧传感器的Seabird 19plus V2 SeaCAT Profiler CTD探针进行了23次水文模拟。随后,在CNR Dirigibile Italia北极研究站实验室使用自适应传感平台对水样进行了PO4 3−、NO2−和NO3−分析。将营养物浓度与水文数据进行比较,以评估影响峡湾内营养物浓度的过程。这项研究强调了自适应传感平台在偏远地区作为独立平台和/或用于可部署环境传感器网络验证的潜在用途。
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引用次数: 2
Reduced Graphene Oxide Carbon Yarn Electrodes for Drug Sensing 用于药物传感的还原氧化石墨烯碳丝电极
Pub Date : 2021-08-10 DOI: 10.3389/fsens.2021.719161
S. Sriprasertsuk, Shuai Zhang, G. Wallace, Jun Chen, J. Varcoe, C. Crean
A modified carbon fibre yarn sensor was developed for the voltammetric determination of paracetamol and its interferents (dopamine and ascorbic acid). Reduced graphene oxide (rGO) was electrochemically deposited onto a carbon fibre yarn. Further modification was achieved using polypyrrole (PPy) coated onto the rGO carbon fibre yarn via electropolymerisation of pyrrole with cyclic voltammetry (CV). The surface of the rGO and PPy-rGO carbon fibre electrodes were characterised using Raman spectroscopy and scanning electron microscopy. The rGO and PPy-rGO carbon fibres had a 3.5-fold and 7-fold larger electrochemical surface area compared to bare carbon fibre (calculated using the Randles-Sevcik equation). Two clearly distinguished oxidation peaks at 0.49 and 0.25 V (vs. Ag/AgCl) were observed at the rGO fibre electrode during the simultaneous detection of paracetamol and dopamine, respectively, by CV. The detection limit (3σ S/N) of the rGO carbon fibre electrode for differential pulse voltammetry (DPV) determination of paracetamol was at 21.1 and 6.0 µM for dopamine. In comparison, the simultaneous determination of paracetamol and dopamine by CV at the PPy-rGO fibre electrode gave oxidation peaks of paracetamol and dopamine at 0.55 and 0.25 V (vs. Ag/AgCl), respectively. The detection limit (3σ S/N) for paracetamol was notably improved to 3.7 µM and maintained at 6.0 µM for dopamine at the PPy-rGO carbon fibre electrode during DPV.
研制了一种改进的碳纤维纱线传感器,用于对乙酰氨基酚及其干扰物质(多巴胺和抗坏血酸)的伏安测定。将还原氧化石墨烯(rGO)电化学沉积在碳纤维纱线上。通过用循环伏安法(CV)对吡咯进行电聚合,使用涂覆在rGO碳纤维纱线上的聚吡咯(PPy)实现了进一步的改性。使用拉曼光谱和扫描电子显微镜对rGO和PPy-rGO碳纤维电极的表面进行了表征。与裸碳纤维相比(使用Randles-Sevcik方程计算),rGO和PPy-rGO碳纤维的电化学表面积分别大3.5倍和7倍。在用CV同时检测对乙酰氨基酚和多巴胺的过程中,在rGO纤维电极上分别观察到0.49和0.25V(相对于Ag/AgCl)处的两个明显区分的氧化峰。rGO碳纤维电极用于差示脉冲伏安法(DPV)测定对乙酰氨基痛的检测限(3σS/N)为21.1和6.0µM。相比之下,在PPy-rGO纤维电极上通过CV同时测定对乙酰氨基酚和多巴胺,分别在0.55和0.25V(相对于Ag/AgCl)处产生对乙酰氨基苯酚和多巴胺的氧化峰。DPV期间,在PPy-rGO碳纤维电极上,对乙酰氨基酚的检测限(3σS/N)显著提高至3.7µM,多巴胺的检测限保持在6.0µM。
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引用次数: 1
Using Deep Learning Neural Network in Artificial Intelligence Technology to Classify Beef Cuts 利用人工智能技术中的深度学习神经网络对牛肉切块进行分类
Pub Date : 2021-06-15 DOI: 10.3389/fsens.2021.654357
Sunil Gc, Borhan Saidul Md, Yu Zhang, D. Reed, M. Ahsan, E. Berg, Xin Sun
The objective of this research was to evaluate the deep learning neural network in artificial intelligence (AI) technologies to rapidly classify seven different beef cuts (bone in rib eye steak, boneless rib eye steak, chuck steak, flank steak, New York strip, short rib, and tenderloin). Color images of beef samples were acquired from a laboratory-based computer vision system and collected from the Internet (Google Images) platforms. A total of 1,113 beef cut images were used as training, validation, and testing data subsets for this project. The model developed from the deep learning neural network algorithm was able to classify certain beef cuts (flank steak and tenderloin) up to 100% accuracy. Two pretrained convolution neutral network (CNN) models Visual Geometry Group (VGG16) and Inception ResNet V2 were used to train, validate, and test these models in classifying beef cut images. An image augmentation technique was incorporated in the convolution neutral network models for avoiding the overfitting problems, which demonstrated an improvement in the performance of the image classifier model. The VGG16 model outperformed the Inception ResNet V2 model. The VGG16 model coupled with data augmentation technique was able to achieve the highest accuracy of 98.6% on 116 test images, whereas Inception ResNet V2 accomplished a maximum accuracy of 95.7% on the same test images. Based on the performance metrics of both models, deep learning technology evidently showed a promising effort for beef cuts recognition in the meat science industry.
本研究的目的是评估人工智能(AI)技术中的深度学习神经网络,以快速分类七种不同的牛肉(带骨肋眼牛排、无骨肋眼牛肉、查克牛排、侧翼牛排、纽约条、短肋排和里脊肉)。牛肉样本的彩色图像是从基于实验室的计算机视觉系统获取的,并从互联网(谷歌图像)平台收集。共有1113张牛肉切片图像被用作该项目的训练、验证和测试数据子集。由深度学习神经网络算法开发的模型能够对某些牛肉切片(侧翼牛排和里脊肉)进行高达100%的准确度分类。使用两个预训练的卷积神经网络(CNN)模型Visual Geometry Group(VGG16)和Inception ResNet V2对这些模型进行训练、验证和测试,以对牛肉切片图像进行分类。在卷积神经网络模型中引入了图像增强技术,以避免过拟合问题,这表明图像分类器模型的性能有所提高。VGG16模型的性能优于Inception ResNet V2模型。VGG16模型与数据增强技术相结合,能够在116张测试图像上实现98.6%的最高精度,而Inception ResNet V2在相同的测试图像上达到95.7%的最高精度。基于这两个模型的性能指标,深度学习技术显然在肉类科学行业的牛肉切片识别方面显示出了很有希望的努力。
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引用次数: 10
Improved Stability and Performance of Surface Acoustic Wave Nanosensors Using a Digital Temperature Compensation 采用数字温度补偿提高声表面波纳米传感器的稳定性和性能
Pub Date : 2021-06-14 DOI: 10.3389/fsens.2021.617484
S. Balashov, J. Rocha, M. R. F. Hurtado, J. A. L. Prestes, A. F. M. de Campos, S. Moshkalev
Surface Acoustic Waves (SAW) sensors are known to be an excellent choice for the measurement of a small concentration of analytes in gas mixtures. The use of this type of sensor has been limited until now in the industrial environment due to the sensitivity of its response to temperature variations. To overcome this problem, thermal stabilization of equipment is normally used. We propose here a simple procedure of compensation of thermal drift in SAW sensors, allowing the measurements to be performed in temperature intervals of up to 20 degrees without any thermal stabilization of the sensitive element of a sensor. By monitoring the temperature of the key points of the sensor and applying the proposed polynomial compensation, it is possible to reduce the influence of thermal instabilities of the ambient temperature to the response more than four times. The method is illustrated by a temperature compensated SAW humidity sensor with a graphene oxide nanofilm as water molecules’ sensitive element. The results show enhanced performance of the sensor over a large temperature interval.
表面声波(SAW)传感器被认为是测量气体混合物中小浓度分析物的绝佳选择。由于其对温度变化的响应灵敏度高,这种类型的传感器的使用到目前为止在工业环境中一直受到限制。为了克服这个问题,通常使用设备的热稳定。我们在这里提出了一种简单的SAW传感器热漂移补偿程序,允许在高达20度的温度间隔内进行测量,而无需传感器敏感元件的任何热稳定。通过监测传感器关键点的温度并应用所提出的多项式补偿,可以将环境温度的热不稳定性对响应的影响降低四倍以上。以氧化石墨烯纳米膜作为水分子敏感元件的温度补偿SAW湿度传感器为例说明了该方法。结果表明,在较大的温度区间内,传感器的性能得到了提高。
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引用次数: 2
Specialty Grand Challenge: Sensor Networks 专业大挑战:传感器网络
Pub Date : 2021-06-01 DOI: 10.3389/fsens.2021.700967
Guangjie Han
Nowadays, Sensors have been deployed all over the daily living environment, integrated into smart phones, smart watches, and other wireless terminal devices, and become the necessities in modern daily life. With the progress of IoT (Internet of Things) and AI (artificial intelligence), more wireless sensing devices will be used to extend human senses for providing accurate and comprehensive sensory data of life activities via networking. The International Data Corporation (IDC) reports that both the number of online devices and total generated data will reach unprecedented magnitudes in 2025. Their exponential increase heralds the advent of a new era named “Internet of Everything (IoE)”. Obviously, mass data is an opportunity to develop data-driven technologies, but also a challenge for computational loading capacity. Given the transmission cost, information security, and system scalability, Sensor Network based schemes may be the current optimal solution (Akyildiz et al., 2002). The field of Sensor Networks has gone through three major reforms ranging from version 1.0 (isolated static systems) to 3.0 (invisible adaptive, self-managing systems), each of which has witnessed the revolution of IoT technology. In stage 1.0, i.e., Sensor Networks 1.0, the topics under continuous discussion are about sensor localization, intelligent management, interconnection, etc., on which most of current research products still concentrate. In other words, how to connect our physical world to the Internet through sensor networks is an everlasting hotspot. In moving forward, the fusion of sensors and networks must confront the following challenges:
如今,传感器已经部署在日常生活环境的各个角落,融入到智能手机、智能手表等无线终端设备中,成为现代人日常生活中的必需品。随着物联网(IoT)和人工智能(AI)的发展,更多的无线传感设备将用于扩展人类的感官,通过联网提供准确、全面的生命活动感官数据。国际数据公司(IDC)报告称,到2025年,在线设备的数量和生成的数据总量都将达到前所未有的规模。它们的指数级增长预示着一个名为“万物互联(IoE)”的新时代的到来。显然,海量数据为开发数据驱动技术提供了机遇,但同时也对计算负载能力提出了挑战。考虑到传输成本、信息安全和系统可扩展性,基于传感器网络的方案可能是当前的最佳解决方案(Akyildiz et al., 2002)。传感器网络领域经历了从1.0(孤立的静态系统)到3.0(无形的自适应、自我管理系统)的三次重大变革,每一次都见证了物联网技术的革命。在1.0阶段,即传感器网络1.0,持续讨论的主题是传感器本地化、智能管理、互联互通等,目前的研究成果大多集中在这方面。换句话说,如何通过传感器网络将我们的物理世界连接到互联网是一个永恒的热点。在向前发展的过程中,传感器和网络的融合必须面对以下挑战:
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引用次数: 0
Nitrogen Dioxide Selective Sensor for Humid Environments Based on Octahedral Indium Oxide 基于八面体氧化铟的潮湿环境二氧化氮选择性传感器
Pub Date : 2021-04-26 DOI: 10.3389/fsens.2021.672516
G. Domènech-Gil, I. Gràcia, C. Cané, A. Romano-Rodríguez
We report the growth of micrometer-sized In2O3 octahedral structures, which are next aligned in chains using dielectrophoresis on top of microhotplates with prepatterned electrodes and integrated heater to work as chemoresistive gas sensors. The devices are relatively fast (180 s), highly sensitive (response up to ~256%), and selective toward NO2 in humid environments, showing little response to O2 and ethanol, and being completely insensitive to CO and CH4. The here-presented fabrication method can be easily extended as a cost-effective post-process in CMOS-compatible microhotplate fabrication and, thus, represents a promising candidate for indoor and outdoor air quality monitoring devices.
我们报道了微米大小的In2O3八面体结构的生长,下一步在具有预图案化电极和集成加热器的微热板上使用介电泳将其排列成链,以用作化学电阻式气体传感器。该装置相对快速(180 s),高度灵敏(响应高达~256%),在潮湿环境中对NO2具有选择性,对O2和乙醇的响应很小,对CO和CH4完全不敏感。本文提出的制造方法可以很容易地扩展为CMOS兼容微热板制造中的一种具有成本效益的后工艺,因此,它是室内和室外空气质量监测设备的一个有前途的候选者。
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引用次数: 2
Review: Influences of Semiconductor Metal Oxide Properties on Gas Sensing Characteristics 综述:半导体金属氧化物性质对气敏特性的影响
Pub Date : 2021-04-20 DOI: 10.3389/fsens.2021.657931
B. Saruhan, Roussin Lontio Fomekong, S. Nahirniak
Semiconductor metal oxides (SMOxs) are widely used in gas sensors due to their excellent sensing properties, abundance, and ease of manufacture. The best examples of these sensing materials are SnO2 and TiO2 that have wide band gap and offer unique set of functional properties; the most important of which are electrical conductivity and high surface reactivity. There has been a constant development of SMOx sensor materials in the literature that has been accompanied by the improvement of their gas-sensitive properties for the gas detection. This review is dedicated to compiling of these efforts in order to mark the achievements in this area. The main material-specific aspects that strongly affect the gas sensing properties and can be controlled by the synthesis method are morphology/nanostructuring and dopants to vary crystallographic structure of MOx sensing material.
半导体金属氧化物(SMOxs)由于其优异的传感性能、丰度和易于制造而广泛应用于气体传感器中。这些传感材料的最佳例子是SnO2和TiO2,它们具有宽带隙并提供独特的功能特性;其中最重要的是导电性和高表面反应性。在文献中,SMOx传感器材料一直在不断发展,伴随着气体检测的气敏性能的提高。本次审查致力于汇编这些努力,以表明在这一领域取得的成就。影响MOx气体感测性能的主要因素是材料的形貌/纳米结构和掺杂剂改变MOx感测材料的晶体结构。
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引用次数: 86
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Frontiers in sensors
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