Acta otorrinolaringologica espanola最新文献

{"title":"Management of orbital complications of acute rhinosinusitis: A 13-year experience","authors":"Monica Rueda Vega ,&nbsp;M Montserrat Asensi Diaz ,&nbsp;María C Scola Torres ,&nbsp;Carolina López Granados ,&nbsp;Mónica Hernando ,&nbsp;Juan Antonio Pasamontes","doi":"10.1016/j.otoeng.2025.512262","DOIUrl":"10.1016/j.otoeng.2025.512262","url":null,"abstract":"<div><h3>Introduction</h3><div>After the development of antibiotics and early diagnostic methods, the complications of acute rhinosinusitis (ARS) have reduced in recent years. However, in clinical practice, we still observe both orbital and intracranial complications.</div><div>The aim of this study is to describe a series of patients with complications of ARS and to define what clinical and radiological characteristics may indicate the need of surgical treatment.</div></div><div><h3>Materials</h3><div>Retrospective observational study of patients diagnosed with orbital complications secondary to ARS who were hospitalized at a tertiary hospital between 2010 and 2023. Demographic, clinical, radiological, microbiological data, therapeutic strategy and hospitalization time were studied.</div></div><div><h3>Results</h3><div><span><span>Fifty-six patients were included (59% male), with a mean age of 11.5 years (37 under 18 years old). The most frequent symptoms were eyelid edema (98%) and erythema (89%), </span>proptosis (46%) and fever (50%). According to Chandler’s classification, the most frequent complications were subperiosteal abscesses (46%) and </span>orbital cellulitis<span> (23%). There were six cases of orbital abscesses and one cavernous sinus thrombosis. The most frequently used antibiotic was amoxicillin + clavulanic acid (54%). Surgical intervention was necessary in 26 patients (46%).</span></div></div><div><h3>Conclusion</h3><div>Orbital complications of ARS are rare, but they can have potentially vision-threatening and life-threatening complications. Therefore, it is essential to consider them in the differential diagnosis, and in case of suspicion, initiate antibiotic treatment as soon as possible, with or without surgical drainage<span>. Endoscopic surgery is the preferred approach, but it may be necessary to combine it with external drainage, especially in lateral locations or on the orbital roof.</span></div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 5","pages":"Article 512262"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otorhinolaryngological manifestations in patients with eosinophilic granulomatosis with polyangiitis in a single university center","authors":"Julia Fernández-Enseñat ,&nbsp;Fabricio Benavides-Villanueva ,&nbsp;Andrea Martínez-Camerano ,&nbsp;Vanesa Calvo-Rio ,&nbsp;Ricardo Blanco ,&nbsp;Carmelo Morales-Angulo","doi":"10.1016/j.otoeng.2025.512263","DOIUrl":"10.1016/j.otoeng.2025.512263","url":null,"abstract":"<div><h3>Objectives</h3><div><span><span><span>Eosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis affecting multiple systems, with common ear, nose and throat (ENT) manifestations. This study aimed to evaluate the most frequent ENT manifestations in EGPA patients and the relationship between </span>nasal polyps and other clinical findings such as </span>ANCA tests and </span>eosinophilia.</div></div><div><h3>Materials and methods</h3><div><span>A retrospective observational study was conducted on EGPA patients diagnosed between 2000 and 2024 at a tertiary hospital using the 2022 ACR/EULAR criteria. Head and neck examinations, including audiometry, and their imaging and histopathological studies were reviewed. Patients were classified based on the presence or absence of nasal polyps, and the relationship between </span>ANCA positivity and eosinophilia was assessed.</div></div><div><h3>Results</h3><div>Of 173 patients with ANCA vasculitis, 22 met EGPA criteria, with a prevalence of 3.6 per 100,000 in Cantabria. Head and neck manifestations were observed in 90.5% of patients (19/21). Sinonasal involvement was the most frequent (82%), with otological manifestations in 31.8% (7/21). Nasal polyps were the most common manifestation (7/21). Head and neck biopsies were performed in 7 cases (32%), which showed no evidence of vasculitis. There was no statistically significant association between nasal polyps, ANCA positivity, and eosinophilia.</div></div><div><h3>Conclusions</h3><div>Sinonasal involvement is prevalent in EGPA, often presenting as chronic rhinitis<span><span> or rhinosinusitis with or without polyps. Otological issues, such as eustachian tube dysfunction and sensorineural hearing loss, are also common. No laryngeal, oral, or </span>salivary gland lesions were observed. There was no significant correlation between the presence of polyps and ANCA positivity or eosinophilia.</span></div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 5","pages":"Article 512263"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant intratympanic internal carotid artery","authors":"Saúl Astray-Gómez ,&nbsp;Celia Montón-Gómez ,&nbsp;Carlos de Paula-Vernetta","doi":"10.1016/j.otoeng.2025.512268","DOIUrl":"10.1016/j.otoeng.2025.512268","url":null,"abstract":"","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 5","pages":"Article 512268"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease control in unresectable laryngeal carcinoma cuniculatum using pembrolizumab and chemotherapy: A case report","authors":"Natalia Arango Cabezas ,&nbsp;Rosa Delia Ramirez-Ruiz ,&nbsp;Nuria Cuesta ,&nbsp;Isabel Vilaseca","doi":"10.1016/j.otoeng.2025.512270","DOIUrl":"10.1016/j.otoeng.2025.512270","url":null,"abstract":"","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 5","pages":"Article 512270"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the EPOS 2020 and POLINA 2.0 guidelines for indicating biologic treatment in adults with chronic rhinosinusitis and nasal polyps","authors":"Mireia Golet ,&nbsp;Núria Padullés-Zamora ,&nbsp;Alejandro Portillo ,&nbsp;José María Caballero ,&nbsp;Mariana Muñoz Esquerre ,&nbsp;Joaquín Sastre ,&nbsp;Isam Alobid ,&nbsp;Xavier González-Compta","doi":"10.1016/j.otoeng.2025.512224","DOIUrl":"10.1016/j.otoeng.2025.512224","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the volume of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) to whom biologics would be prescribed based on the European and Spanish clinical practice guidelines, and to evaluate the impact that an increase of 1 required prior surgery (from 1 to 2) may have on the number of indications.</div></div><div><h3>Methods</h3><div>Cross-sectional analysis evaluating the application of the European Position Paper on CRSwNP Guidelines (EPOS 2020) and the Spanish Consensus on the Management of CRSwNP Guidelines (POLINA 2.0) on an on-going prospective cohort study of consecutive patients with severe CRSwNP in a tertiary hospital.</div></div><div><h3>Results</h3><div>For a total of 103 patients with severe CRSwNP, 57.3% met EPOS 2020 criteria for biological treatment, whereas only 32% met POLINA 2.0 criteria. However, if the number of surgeries required to prescribe a biological therapy is increased to 2, only 31.1% of the patients would have indication of biological treatment, in any of the two guidelines.</div></div><div><h3>Conclusions</h3><div>The differences among the POLINA 2.0 and the EPOS 2020 guidelines appear to have an impact in the proportion of patients eligible for biological therapies, with the former being stricter. Increasing the number of prior surgeries required, reduces the proportion of patients eligible for monoclonal antibodies prescription.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 4","pages":"Article 512224"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical variations of sphenoid sinus on cone beam computed tomography","authors":"Patrícia Fernandes Lopes ,&nbsp;Tatiana Carvalho ,&nbsp;Miguel Furtado","doi":"10.1016/j.otoeng.2025.512229","DOIUrl":"10.1016/j.otoeng.2025.512229","url":null,"abstract":"<div><h3>Introduction</h3><div>The surgical approach to the sphenoid sinus (SS) is one of the most challenging aspects of endoscopic surgery due to its proximity to critical structures. To minimize risks, computed tomography (CT) aids in navigational guidance. Although cone beam computed tomography (CBCT) has lower contrast resolution, it offers improved precision, reduced radiation exposure, and faster imaging, making it a viability as a preoperative tool.</div></div><div><h3>Methods</h3><div>We randomly selected 75 patients from 707 who underwent CBCT between January and December 2023. Two observers evaluated SS anatomy with consensus. Statistical analyses were conducted using Excel® and Jamovi®.</div></div><div><h3>Results</h3><div>Anatomical variations were documented, with prevalence rates as follows: sphenoethmoidal cell (15%); optic nerve (ON) protrusion (21%) and dehiscence (4%); internal carotid artery (ICA) protrusion (31%) and dehiscence (0%); vidian canal (VC) protrusion (39%) and dehiscence (6%); foramen rotundum (FR) protrusion (23%) and dehiscence (5%); anterior clinoid process (ACP) pneumatization (20%); pterygoid process (PP) pneumatization (33%); conchal (1%), presellar (7%), sellar (36%) and postsellar type (56%) SS; and intersphenoidal septum (47%). Statistically significant correlations were observed between ACP pneumatization and ON protrusion (<em>p</em> &lt; 0.001) and dehiscence (<em>p</em> = 0.018), and ICA protrusion (<em>p</em> = 0.001). PP pneumatization was significantly correlated with VC protrusion (<em>p</em> &lt; 0.001) and dehiscence (<em>p</em> = 0.011), and foramen rotundum protrusion (<em>p</em> &lt; 0.001).</div></div><div><h3>Discussion/Conclusion</h3><div>Our CBCT findings largely aligned with CT data in existing literature. Due to its faster acquisition and lower radiation exposure, CBCT shows potential as a preoperative evaluation method for assessing the SS.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 4","pages":"Article 512229"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory complications in patients undergoing surgery for oral cavity, pharyngeal, and laryngeal cancer in a tertiary hospital","authors":"Marta Zabaleta López ,&nbsp;Belén Clemente Cuartero ,&nbsp;Pedro Díaz de Cerio Canduela ,&nbsp;Nisa Boukichou Abdelkader ,&nbsp;Javier Ugedo Urruela","doi":"10.1016/j.otoeng.2025.512236","DOIUrl":"10.1016/j.otoeng.2025.512236","url":null,"abstract":"<div><h3>Background and objective</h3><div>The incidence of head and neck cancer (HNC) is directly related to tobacco and alcohol consumption, which explains why patients with HNC often present comorbidities, with chronic obstructive pulmonary disease (COPD) being an example. This condition is underdiagnosed, and various authors have demonstrated how its presence increases the incidence of respiratory complications in patients undergoing surgery for HNC.</div><div>We conducted a study aimed at evaluating respiratory complications in patients undergoing surgery for HNC at the San Pedro University Hospital (HUSP).</div></div><div><h3>Materials and methods</h3><div>A retrospective and descriptive study was conducted, including all adult patients diagnosed with oral cavity, pharyngeal, or laryngeal carcinoma who underwent surgery at the San Pedro University Hospital (HUSP) in Logroño between 2018 and 2021. Sociodemographic variables, medical history, previous pulmonary evaluation, and respiratory complications were recorded. A two-year follow-up was carried out.</div></div><div><h3>Results</h3><div>A total of 160 patients were included. 74.4% of the patients were men, and the mean age was 72 years. 69.4% had a smoking habit, and 41.2% consumed alcohol. Comorbidities were documented in 82.5% of patients, with hypertension being the most prevalent, while COPD ranked fifth at 8.1%. Prior to surgery, only 16% of patients underwent spirometry, and fewer than 2% were evaluated in the pulmonary clinic.</div><div>Ten patients (6.25%) developed respiratory complications. Of these, 80% were smokers, and 30% had COPD, yet none had been evaluated in the pulmonary clinic prior to surgery. Diabetes mellitus and non-epidermoid cancer types were significantly associated with complications (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>6.25% of patients who underwent surgery for HNC experienced respiratory complications. Although this rate is lower than those reported in other studies, it is noteworthy. This is especially relevant considering that, despite 30% of these patients having a prior diagnosis of COPD, none were evaluated before surgery to optimise treatment for this condition. These findings underscore the importance of identifying and managing COPD in patients with HNC and the need for further research in this area.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 4","pages":"Article 512236"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where are we heading with sleep medicine? A study of multidisciplinary units in Spain","authors":"Laura Rodriguez Alcala ,&nbsp;Carlos O’Connor-Reina ,&nbsp;Carlos Egea ,&nbsp;F. Javier Puertas ,&nbsp;Milagros Merino ,&nbsp;Marina Carrasco ,&nbsp;Jose Maria Ignacio ,&nbsp;Peter Baptista ,&nbsp;Guillermo Plaza","doi":"10.1016/j.otoeng.2025.512234","DOIUrl":"10.1016/j.otoeng.2025.512234","url":null,"abstract":"","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 4","pages":"Article 512234"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A look at DFNB16 markers and their application in the genetic study of hearing loss in Iranian deaf families","authors":"Reihane Fazeli-Jezei ,&nbsp;Elham Davoudi-Dehaghani","doi":"10.1016/j.otoeng.2025.512230","DOIUrl":"10.1016/j.otoeng.2025.512230","url":null,"abstract":"<div><h3>Introduction</h3><div>The study of the gene encoding stereocilin (<em>STRC</em>) is complicated by the presence of a pseudogene (<em>STRCP1</em>) with over 98.8% similarity. We analysed the linkage between hearing loss and the DFNB16 locus in consanguineous Iranian deaf families.</div></div><div><h3>Materials and methods</h3><div>A review of previous studies on the DFNB16 locus was conducted to find the smallest regions linked to the <em>STRC</em> gene with no reported crossing-overs, as well as an investigation of short tandem repeat (STR) and single nucleotide polymorphism (SNP) markers of the DFNB16 locus using the UCSC, NCBI, and Iranome databases. A total of 36 consanguineous families with at least two individuals affected by autosomal recessive non-syndromic hearing loss (ARNSHL) were selected for the study. Autozygosity mapping was performed using tag SNP markers linked to the DFNB16 locus.</div></div><div><h3>Results</h3><div>The investigation showed that SNPs are more appropriate for linkage studies in these families than STR markers. In this study, 12 distinct haplotypes were identified, with frequencies ranging from 3.1% to 21.8%. Based on the haplotype analysis results and the autozygosity mapping, no linkage was found in any families analysed.</div></div><div><h3>Discussion</h3><div>In genetic studies of deafness in multi-affected consanguineous families, preliminary screening by autozygosity mapping can be helpful, especially for complicated genes like <em>STRC</em>. If the distance between STRs and the gene under study is significant, SNPs can provide a more effective solution. This study can potentially help to develop a more cost-effective method for genetic testing of <em>STRC</em>-related deafness.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 4","pages":"Article 512230"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of chronic rhinosinusitis with nasal polyps on Eustachian tube dysfunction","authors":"Francisco Javier García-Callejo ,&nbsp;Miguel Juantegui-Azpilicueta ,&nbsp;María Díaz-Ferrer ,&nbsp;Pablo Tiziano Guastella Almeida ,&nbsp;John Deiver Cardona Henao","doi":"10.1016/j.otoeng.2025.512235","DOIUrl":"10.1016/j.otoeng.2025.512235","url":null,"abstract":"<div><h3>Introduction</h3><div>Adequate nasal patency has been classically considered a crucial factor in middle ear ventilation. We valued the influence of nasosinusal polyposis on Eustachian tube (ET) function.</div></div><div><h3>Material and methods</h3><div>A prospective follow-up with all cases of chronic rhinosinusitis with nasal polyps (CRSwNP) assisted between January 2019 and October 2024 was carried out. Their endoscopic, radiological and clinical characteristics were noted, as well as the presence of a type 2 inflammation context (T2I) and the incidence of middle ear pathology. Polypoid involvement and tubal dysfunction were studied using several scores: Lidholdt’s scale, Lund-McKay nasal polyp grading, Lund-Kennedy endoscopic scoring system, SNOT-22 and Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7) score.</div></div><div><h3>Results</h3><div>Information was collected from 155 patients, with an incidence of 15,1 cases/100,000 inhabitants. 70,9% showed an T2I profile. This group showed a higher average of cases with acute otitis media and effusion (18,1% vs. 4,4%; <em>P</em> &lt; .001), tympanometric alterations (12,7% vs. 4,4%; <em>P</em> &lt; 0.01), conductive hearing loss (17,2%. vs 4,4%; <em>P</em> &lt; 0.001) and needing for transtympanic drains (9,1% vs. 2,2%; <em>P</em> &lt; .01) than the group without an eosinophilic profile or elevated IgE. The ETDQ-7 score correlated well with the SNOT-22 and Lund-Kennedy scales.</div></div><div><h3>Conclusions</h3><div>Regression analysis revealed that an T2I profile might play a more important role in tubal patency than nasal obstruction. Polyposis may alter ET function, but more likely due to its inflammatory-allergic aetiopathogenesis than to its obstructive nature.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 4","pages":"Article 512235"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}