Pub Date : 2024-05-14DOI: 10.1097/hm9.0000000000000111
Bo Zhang
{"title":"Traditional Chinese Medicine in the Upcoming Radiation Era","authors":"Bo Zhang","doi":"10.1097/hm9.0000000000000111","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000111","url":null,"abstract":"","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-09DOI: 10.1097/hm9.0000000000000109
Yao Nie, Mingyue Huang, Tingyu Yang, Yu Mei, Huiting Zhang, Xue Wei, Yue Gao, Zengchun Ma
A model of inflammatory damage was induced by radiation to investigate whether ferulic acid (FA) can reduce the inflammatory response through the Sirt1-NLRP3 inflammatory pathway. This will help discover radiation-protective drugs and elucidate the molecular mechanisms related to radiation-induced inflammatory damage. A mouse model of radiation-induced immunoinflammatory injury was established to verify the anti-inflammatory effects of FA in vivo. C57BL/6J mice were randomly divided into six groups, and 5 Gy whole body irradiation was used for modeling. Mice were administered a gastric solvent, amifostine, or 25, 50, or 100 mg/kg FA daily for 12 d, consecutively, before irradiation. The serum of mice was collected 24 h after irradiation to observe the content of inflammatory factors interleukin (IL)-1β, IL-18, IL-6, and tumor necrosis factor (TNF)-α. The spleen and thymus tissues of mice were weighed and the organ index was calculated for pathological testing and immunofluorescence detection. FA reduced the radiation-induced decrease in the spleen and thymus indices. FA significantly reduced the secretion of inflammatory factors in the serum and reversed the radiation-induced reduction in lymphocytes in the spleen and thymus of mice. FA activated Sirt1 and inhibited the expression of the NLRP3 inflammasome to alleviate the inflammatory response. FA reduced radiation-induced inflammation in animals, possibly by activating Sirt1 and reducing nucleotide oligomerization domain (NOD)-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome expression, thereby reducing the secretion of inflammatory factors.
{"title":"Ferulic Acid Reduces Inflammatory Response Induced by Radiation through Sirt1-NLRP3 Pathway","authors":"Yao Nie, Mingyue Huang, Tingyu Yang, Yu Mei, Huiting Zhang, Xue Wei, Yue Gao, Zengchun Ma","doi":"10.1097/hm9.0000000000000109","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000109","url":null,"abstract":"\u0000 \u0000 A model of inflammatory damage was induced by radiation to investigate whether ferulic acid (FA) can reduce the inflammatory response through the Sirt1-NLRP3 inflammatory pathway. This will help discover radiation-protective drugs and elucidate the molecular mechanisms related to radiation-induced inflammatory damage.\u0000 \u0000 \u0000 \u0000 A mouse model of radiation-induced immunoinflammatory injury was established to verify the anti-inflammatory effects of FA in vivo. C57BL/6J mice were randomly divided into six groups, and 5 Gy whole body irradiation was used for modeling. Mice were administered a gastric solvent, amifostine, or 25, 50, or 100 mg/kg FA daily for 12 d, consecutively, before irradiation. The serum of mice was collected 24 h after irradiation to observe the content of inflammatory factors interleukin (IL)-1β, IL-18, IL-6, and tumor necrosis factor (TNF)-α. The spleen and thymus tissues of mice were weighed and the organ index was calculated for pathological testing and immunofluorescence detection.\u0000 \u0000 \u0000 \u0000 FA reduced the radiation-induced decrease in the spleen and thymus indices. FA significantly reduced the secretion of inflammatory factors in the serum and reversed the radiation-induced reduction in lymphocytes in the spleen and thymus of mice. FA activated Sirt1 and inhibited the expression of the NLRP3 inflammasome to alleviate the inflammatory response.\u0000 \u0000 \u0000 \u0000 FA reduced radiation-induced inflammation in animals, possibly by activating Sirt1 and reducing nucleotide oligomerization domain (NOD)-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome expression, thereby reducing the secretion of inflammatory factors.\u0000","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1097/hm9.0000000000000104
Huan Zhong, Zhi-Qing Tang, Yi-Fang Li, Mei Wang, Wan-Yang Sun, Rong-Rong He
{"title":"The Evolution and Significance of Medicine and Food Homology","authors":"Huan Zhong, Zhi-Qing Tang, Yi-Fang Li, Mei Wang, Wan-Yang Sun, Rong-Rong He","doi":"10.1097/hm9.0000000000000104","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000104","url":null,"abstract":"","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"108 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140079399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1097/hm9.0000000000000105
Xuechun Chen, Lu Li, Mingxu Zhang, Jian Yang, ChunMing Lyu, Yizhou Xu, Yang Yang, Yi Wang
High-content screening (HCS) technology combines automated high-speed imaging hardware and single-cell quantitative analysis. It can greatly accelerate data acquisition in cellular fluorescence imaging and is a powerful research technique in traditional Chinese medicine (TCM). An increasing number of laboratories and platforms, including TCM laboratories, have begun utilizing HCS systems. However, this technology is still in its infancy in TCM research and there is a lack of sufficient experience with the associated concepts, instrument configurations, and analysis methods. To improve the understanding of HCS among researchers in the field of TCM, this paper summarizes the concept of HCS, software and hardware configuration, the overall research process, as well as common problems and related solutions of HCS in TCM research based on our team’s previous research experience, providing several research examples and an outlook on future perspectives, aiming to provide a technical guide for HCS in TCM research.
{"title":"Guidelines for Application of High-Content Screening in Traditional Chinese Medicine: Concept, Equipment, and Troubleshooting","authors":"Xuechun Chen, Lu Li, Mingxu Zhang, Jian Yang, ChunMing Lyu, Yizhou Xu, Yang Yang, Yi Wang","doi":"10.1097/hm9.0000000000000105","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000105","url":null,"abstract":"High-content screening (HCS) technology combines automated high-speed imaging hardware and single-cell quantitative analysis. It can greatly accelerate data acquisition in cellular fluorescence imaging and is a powerful research technique in traditional Chinese medicine (TCM). An increasing number of laboratories and platforms, including TCM laboratories, have begun utilizing HCS systems. However, this technology is still in its infancy in TCM research and there is a lack of sufficient experience with the associated concepts, instrument configurations, and analysis methods. To improve the understanding of HCS among researchers in the field of TCM, this paper summarizes the concept of HCS, software and hardware configuration, the overall research process, as well as common problems and related solutions of HCS in TCM research based on our team’s previous research experience, providing several research examples and an outlook on future perspectives, aiming to provide a technical guide for HCS in TCM research.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"122 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140078715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1097/hm9.0000000000000106
Zi Guo, Naixuan Wei, Ru Ye, Tiancheng Sun, Shuang Qiu, Xiaomei Shao, Xiaochang Ge, Lu Guan, Junfang Fang, Jianqiao Fang, Junying Du
Electroacupuncture (EA) is an alternative treatment option for pain. Different frequencies of EA have different pain-relieving effects; however, the central mechanism is still not well understood. The FosTRAP:Ai9 mice were divided into three groups (sham, 2 Hz, and 100 Hz). The mice were intraperitoneally injected with 4-hydroxytamoxifen (4-OHT) immediately after EA at Zusanli (ST36) for 30 min to record the activated neurons. One week later, the mice were sacrificed, and the number of TRAP-treated neurons activated by EA in the thalamus, amygdala, cortex, and hypothalamus was determined. In the cortex, 2 Hz EA activated more TRAP-treated neurons than 100 Hz EA did in the cingulate cortex area 1 (Cg1) and primary somatosensory cortex (S1), and 2 Hz and 100 Hz EAs did not differ from sham EA. TRAP-treated neurons activated by 2 Hz EA were upregulated in the insular cortex (IC) and secondary somatosensory cortex (S2) compared with those activated by 100 Hz and sham EA. In the thalamus, the number of TRAP-treated neurons activated by 2 Hz EA was elevated in the paraventricular thalamic nucleus (PV) compared with those activated by sham EA. In the ventrolateral thalamic nucleus (VL), the number of TRAP-treated neurons activated by 2 Hz EA was significantly upregulated compared with those activated by 100 Hz EA, and sham EA showed no difference compared to 2 Hz EA or 100 Hz EA. TRAP-treated neurons were more frequently activated in the ventral posterolateral thalamic nucleus (VPL) by 2 Hz EA than by 100 Hz or sham EA. Low-frequency EA ST36 effectively activates neurons in the Cg1, S1, S2, IC, VPL, PV, and VL. The enhanced excitability of the aforementioned nuclei induced by low-frequency EA may be related to its superior efficacy in the treatment of neuropathological pain.
电针（EA）是治疗疼痛的一种替代疗法。不同频率的电针具有不同的止痛效果，但其中心机制仍不甚明了。 FosTRAP:Ai9 小鼠被分为三组（假、2 Hz 和 100 Hz）。小鼠在祖山里（ST36）EA 30 分钟后立即腹腔注射 4-羟基他莫昔芬（4-OHT），记录激活的神经元。一周后，小鼠被处死，测定丘脑、杏仁核、皮层和下丘脑中被EA激活的TRAP处理神经元数量。 在大脑皮层，在扣带回皮层 1 区（Cg1）和初级躯体感觉皮层（S1），2 赫兹 EA 比 100 赫兹 EA 激活的 TRAP 处理神经元更多，2 赫兹和 100 赫兹 EA 与假 EA 没有区别。在岛叶皮层（IC）和次级躯体感觉皮层（S2），2赫兹EA激活的TRAP处理神经元与100赫兹和假EA激活的神经元相比上调。在丘脑中，与假 EA 激活的神经元相比，2 Hz EA 激活的丘脑室旁核（PV）中 TRAP 处理的神经元数量增加。在丘脑腹外侧核（VL），与 100 Hz EA 相比，2 Hz EA 激活的 TRAP 处理神经元数量显著增加，而假 EA 与 2 Hz EA 或 100 Hz EA 相比没有差异。与 100 Hz 或假 EA 相比，2 Hz EA 更频繁地激活丘脑腹后外侧核（VPL）中的 TRAP 处理神经元。 低频 EA ST36 能有效激活 Cg1、S1、S2、IC、VPL、PV 和 VL 中的神经元。低频 EA 所诱导的上述神经核的兴奋性增强可能与其在治疗神经病理性疼痛方面的卓越疗效有关。
{"title":"Map activation of various brain regions using different frequencies of electroacupuncture ST36, utilizing the Fos-CreER strategy","authors":"Zi Guo, Naixuan Wei, Ru Ye, Tiancheng Sun, Shuang Qiu, Xiaomei Shao, Xiaochang Ge, Lu Guan, Junfang Fang, Jianqiao Fang, Junying Du","doi":"10.1097/hm9.0000000000000106","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000106","url":null,"abstract":"\u0000 \u0000 Electroacupuncture (EA) is an alternative treatment option for pain. Different frequencies of EA have different pain-relieving effects; however, the central mechanism is still not well understood.\u0000 \u0000 \u0000 \u0000 The FosTRAP:Ai9 mice were divided into three groups (sham, 2 Hz, and 100 Hz). The mice were intraperitoneally injected with 4-hydroxytamoxifen (4-OHT) immediately after EA at Zusanli (ST36) for 30 min to record the activated neurons. One week later, the mice were sacrificed, and the number of TRAP-treated neurons activated by EA in the thalamus, amygdala, cortex, and hypothalamus was determined.\u0000 \u0000 \u0000 \u0000 In the cortex, 2 Hz EA activated more TRAP-treated neurons than 100 Hz EA did in the cingulate cortex area 1 (Cg1) and primary somatosensory cortex (S1), and 2 Hz and 100 Hz EAs did not differ from sham EA. TRAP-treated neurons activated by 2 Hz EA were upregulated in the insular cortex (IC) and secondary somatosensory cortex (S2) compared with those activated by 100 Hz and sham EA. In the thalamus, the number of TRAP-treated neurons activated by 2 Hz EA was elevated in the paraventricular thalamic nucleus (PV) compared with those activated by sham EA. In the ventrolateral thalamic nucleus (VL), the number of TRAP-treated neurons activated by 2 Hz EA was significantly upregulated compared with those activated by 100 Hz EA, and sham EA showed no difference compared to 2 Hz EA or 100 Hz EA. TRAP-treated neurons were more frequently activated in the ventral posterolateral thalamic nucleus (VPL) by 2 Hz EA than by 100 Hz or sham EA.\u0000 \u0000 \u0000 \u0000 Low-frequency EA ST36 effectively activates neurons in the Cg1, S1, S2, IC, VPL, PV, and VL. The enhanced excitability of the aforementioned nuclei induced by low-frequency EA may be related to its superior efficacy in the treatment of neuropathological pain.\u0000","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140263489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-10DOI: 10.1097/hm9.0000000000000087
Lina Pang, Xiaomei Chen, Yanyan Lan, Qiuling Huang, Xiangmei Yu, Lu Qi, Zhifu Wang
The autonomic nervous system (ANS) includes the sympathetic, parasympathetic, and enteric nervous systems, and its senior regulatory center includes the brainstem, cingulate gyrus, and hypothalamus. Acupuncture can affect visceral, vascular, and glandular functions via the autonomic nervous regulatory pathway. In this paper, the relationship between pain and autonomic nervous function, the application of acupuncture guided by the autonomic nervous system, and the basis and clinical research on acupuncture analgesia are reviewed.
{"title":"Research Progress of Acupuncture Analgesia Based on Autonomic Nerve Regulation Pathway","authors":"Lina Pang, Xiaomei Chen, Yanyan Lan, Qiuling Huang, Xiangmei Yu, Lu Qi, Zhifu Wang","doi":"10.1097/hm9.0000000000000087","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000087","url":null,"abstract":"The autonomic nervous system (ANS) includes the sympathetic, parasympathetic, and enteric nervous systems, and its senior regulatory center includes the brainstem, cingulate gyrus, and hypothalamus. Acupuncture can affect visceral, vascular, and glandular functions via the autonomic nervous regulatory pathway. In this paper, the relationship between pain and autonomic nervous function, the application of acupuncture guided by the autonomic nervous system, and the basis and clinical research on acupuncture analgesia are reviewed.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135093245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.1097/hm9.0000000000000085
Xiao Li, Dong Xu, Jianfeng Tu, Bo Pang, Xiaohui Yan, Yuanlu Cui, Yuefei Wang, Cunzhi Liu, Yi Wang, Junhua Zhang
In recent years, significant progress has been achieved in both basic and clinical research within the field of traditional medicine, garnering increasing attention worldwide. To further promote a high-quality and international development of traditional medicine, the editorial board of Acupuncture and Herbal Medicine provided a collection of the “Top 50 High-impact Researches of Traditional Medicine” published in 2021 through objective indicators and a strict selection process. The findings of the selected articles have a significant academic influence and possess considerable academic value both nationally and internationally. The selected articles cover a wide range of topics, including clinical research, acupuncture, pharmacology, chemistry, biosynthesis, medicinal plant resources, and new formulation and drug delivery system research on traditional medicine. Therefore, this article outlines the selection process of the top 50 high-impact research articles, analyzes their research characteristics, and provides a brief summary of their new findings and perspectives in the field of traditional medicine.
{"title":"The “Top 50 High Impact Researches of Traditional Medicine” published in 2021","authors":"Xiao Li, Dong Xu, Jianfeng Tu, Bo Pang, Xiaohui Yan, Yuanlu Cui, Yuefei Wang, Cunzhi Liu, Yi Wang, Junhua Zhang","doi":"10.1097/hm9.0000000000000085","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000085","url":null,"abstract":"In recent years, significant progress has been achieved in both basic and clinical research within the field of traditional medicine, garnering increasing attention worldwide. To further promote a high-quality and international development of traditional medicine, the editorial board of Acupuncture and Herbal Medicine provided a collection of the “Top 50 High-impact Researches of Traditional Medicine” published in 2021 through objective indicators and a strict selection process. The findings of the selected articles have a significant academic influence and possess considerable academic value both nationally and internationally. The selected articles cover a wide range of topics, including clinical research, acupuncture, pharmacology, chemistry, biosynthesis, medicinal plant resources, and new formulation and drug delivery system research on traditional medicine. Therefore, this article outlines the selection process of the top 50 high-impact research articles, analyzes their research characteristics, and provides a brief summary of their new findings and perspectives in the field of traditional medicine.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":" 25","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-24DOI: 10.1097/hm9.0000000000000084
Xiaopeng Chen, Mei Wang
1State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China 2 Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, China 3 Naturalis Biodiversity Center Darwinweg 2, 2333 CR Leiden Postbus 9517, 2300 RA Leiden, Netherlands 4 SU BioMedicine, Galileiweg 8, 2333 BD Leiden, Netherlands Conflict of interest: The authors declare no conflicts of interest. Funding: This study was supported by Haihe Laboratory of Modern Chinese Medicine (22HHZYSS00001). Author contributions: Mei Wang and Xiaopeng Chen conceived the idea for this study, Xiaopeng Chen drafted the manuscript, and Mei Wang and Xiaopeng Chen modified the manuscript. Ethical approval of studies and informed consent: Not applicable. Acknowledgments: None. Data availability: All data used to support the findings of this study have been included in this article. *Corresponding author: Mei Wang Naturalis Biodiversity Center Darwinweg 2 2333 CR Leiden Postbus 9517 2300 RA Leiden E-mail: [email protected] or [email protected] Contributing author’s e-mail address: Xiaopeng Chen: [email protected] This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
{"title":"Traditional Chinese medicine during the COVID-19 pandemic: Recent successes and future perspectives","authors":"Xiaopeng Chen, Mei Wang","doi":"10.1097/hm9.0000000000000084","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000084","url":null,"abstract":"1State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China 2 Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, China 3 Naturalis Biodiversity Center Darwinweg 2, 2333 CR Leiden Postbus 9517, 2300 RA Leiden, Netherlands 4 SU BioMedicine, Galileiweg 8, 2333 BD Leiden, Netherlands Conflict of interest: The authors declare no conflicts of interest. Funding: This study was supported by Haihe Laboratory of Modern Chinese Medicine (22HHZYSS00001). Author contributions: Mei Wang and Xiaopeng Chen conceived the idea for this study, Xiaopeng Chen drafted the manuscript, and Mei Wang and Xiaopeng Chen modified the manuscript. Ethical approval of studies and informed consent: Not applicable. Acknowledgments: None. Data availability: All data used to support the findings of this study have been included in this article. *Corresponding author: Mei Wang Naturalis Biodiversity Center Darwinweg 2 2333 CR Leiden Postbus 9517 2300 RA Leiden E-mail: [email protected] or [email protected] Contributing author’s e-mail address: Xiaopeng Chen: [email protected] This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"476 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-24DOI: 10.1097/hm9.0000000000000083
Lei Wang, Sandugash Myrzagali, Yingqiu Xie, Weiling Pu, Erwei Liu
Malignant tumor has become a major affecting human health, and is one of the main causes of human death. Recent studies have shown that many Traditional Chinese Medicines (TCM) have good antitumor activity, which may improve the therapeutic effect of routine treatment and quality of life with lower toxicity. However, the efficacy of TCM alone for the treatment of tumors is limited. Metal ions are essential substances for maintaining normal physiological activities. This paper summarized the multiple mechanisms that metal ions are involved in the prevention and treatment of tumors in TCM.
{"title":"Metal Ions in Cancer Prevention and Treatment with Traditional Chinese Medicine","authors":"Lei Wang, Sandugash Myrzagali, Yingqiu Xie, Weiling Pu, Erwei Liu","doi":"10.1097/hm9.0000000000000083","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000083","url":null,"abstract":"Malignant tumor has become a major affecting human health, and is one of the main causes of human death. Recent studies have shown that many Traditional Chinese Medicines (TCM) have good antitumor activity, which may improve the therapeutic effect of routine treatment and quality of life with lower toxicity. However, the efficacy of TCM alone for the treatment of tumors is limited. Metal ions are essential substances for maintaining normal physiological activities. This paper summarized the multiple mechanisms that metal ions are involved in the prevention and treatment of tumors in TCM.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"47 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.1097/hm9.0000000000000082
Ming Lyu, Guangxu Xiao, Simeng Wang, Ruijiao Wang, Li Tan, Shibo Ma, Shuang He, Guanwei Fan, Yan Zhu
Chinese guideline has been proven effective in the fight against Coronavirus disease 2019 (COVID-19) during the epidemic spread globally. Traditional Chinese medicine (TCM) has been widely recognized for its effectiveness in alleviating symptoms, inhibiting disease deterioration, reducing mortality, and improving cure rate of COVID-19 patients. During the pandemic, “three medicines and three formulas” stood out from hundreds of registered clinical studies and became the highly recommended TCM for COVID-19 treatment. The “three medicines and three formulas” not only effectively relieve the clinical symptoms of fever, cough, fatigue, and phlegm, but also significantly shorten the time of nucleic acid negative conversion, improve lung computed tomography imaging feature and inflammation, ameliorate clinical biochemical indicators, and reduce sequelae. The potential pharmacological mechanisms of them are mainly relevant with the crosstalk of viral toxicity, endothelial damage, cytokine storm, immune response, and microthrombus. In brief, the clinical effects as well as the potential mechanisms of “three medicines and three formulas” on COVID-19 were systematically analyzed and summarized covering the whole stages of disease development, including virus invasion and replication, immune response and cytokine storm, and acute respiratory distress syndrome and multiple organ dysfunction syndrome. We hope that this review could provide theoretical basis and reference for in-depth understanding the positive role of “three medicines and three formulas” for COVID-19 treatment.
{"title":"“Three medicines and three formulas” in COVID-19: From bench to bedside","authors":"Ming Lyu, Guangxu Xiao, Simeng Wang, Ruijiao Wang, Li Tan, Shibo Ma, Shuang He, Guanwei Fan, Yan Zhu","doi":"10.1097/hm9.0000000000000082","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000082","url":null,"abstract":"Chinese guideline has been proven effective in the fight against Coronavirus disease 2019 (COVID-19) during the epidemic spread globally. Traditional Chinese medicine (TCM) has been widely recognized for its effectiveness in alleviating symptoms, inhibiting disease deterioration, reducing mortality, and improving cure rate of COVID-19 patients. During the pandemic, “three medicines and three formulas” stood out from hundreds of registered clinical studies and became the highly recommended TCM for COVID-19 treatment. The “three medicines and three formulas” not only effectively relieve the clinical symptoms of fever, cough, fatigue, and phlegm, but also significantly shorten the time of nucleic acid negative conversion, improve lung computed tomography imaging feature and inflammation, ameliorate clinical biochemical indicators, and reduce sequelae. The potential pharmacological mechanisms of them are mainly relevant with the crosstalk of viral toxicity, endothelial damage, cytokine storm, immune response, and microthrombus. In brief, the clinical effects as well as the potential mechanisms of “three medicines and three formulas” on COVID-19 were systematically analyzed and summarized covering the whole stages of disease development, including virus invasion and replication, immune response and cytokine storm, and acute respiratory distress syndrome and multiple organ dysfunction syndrome. We hope that this review could provide theoretical basis and reference for in-depth understanding the positive role of “three medicines and three formulas” for COVID-19 treatment.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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