Pub Date : 2023-10-16DOI: 10.1097/hm9.0000000000000081
Chunhui Bao, Jinrong Zhang, Huangan Wu
{"title":"Acupuncture for Crohn’s disease: current status and future perspectives","authors":"Chunhui Bao, Jinrong Zhang, Huangan Wu","doi":"10.1097/hm9.0000000000000081","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000081","url":null,"abstract":"<jats:sec>\u0000 <jats:title />\u0000 </jats:sec>","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.1097/hm9.0000000000000080
Yang Can, Chen Tao, Ma Mengjiao, Li Qiang, Liang Zhichao, Xu Hao, Wang Youhua, Li Ning, Liang Qianqian
Objective: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by multiple joint lesions and systemic complications. Danggui Niantong Decoction (DGNTT) has been clinically used for RA treatment; however, its beneficial effect on cardiopulmonary complications has not been reported. Methods: Female tumor necrosis factor-transgenic (TNF-Tg) mice were used to evaluate the therapeutic effects of DGNTT on arthritis and cardiopulmonary complications. Methotrexate (MTX) served as a positive control. Histopathological assessment of the joint sections was performed using hematoxylin and eosin (H&E), Alcian Blue/Orange G (ABOG), and tartrate-resistant acid phosphatase (TRAP) staining. Bone mass was assessed by micro-computed tomography (CT), inflammatory infiltrates in the heart and lungs were evaluated by H&E staining, cardiopulmonary fibrotic injury was identified by Masson’s trichrome staining, and hypertrophy of mouse cardiomyocytes was measured by wheat germ agglutinin (WGA) staining. Results: DGNTT mitigated the inflammation of the ankle joint synovium, decreased the number of osteoclasts, and increased the area of cartilage and bone mass in TNF-Tg mice. In addition, DGNTT decreased the infiltration of inflammatory cells into the lung and heart tissues, accompanied by a reduction in cardiopulmonary fibrosis and myocardial cell hypertrophy in TNF-Tg mice. As a positive control drug, MTX attenuated the pathological changes in joints, but had no beneficial effect on cardiopulmonary inflammation and fibrosis in TNF-Tg mice. Conclusion: DGNTT improved joint lesions and alleviated cardiopulmonary complications in TNF-Tg mice.
{"title":"Danggui Niantong Decoction ameliorates joint inflammation and cardiopulmonary injury in TNF-Tg mice","authors":"Yang Can, Chen Tao, Ma Mengjiao, Li Qiang, Liang Zhichao, Xu Hao, Wang Youhua, Li Ning, Liang Qianqian","doi":"10.1097/hm9.0000000000000080","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000080","url":null,"abstract":"Objective: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by multiple joint lesions and systemic complications. Danggui Niantong Decoction (DGNTT) has been clinically used for RA treatment; however, its beneficial effect on cardiopulmonary complications has not been reported. Methods: Female tumor necrosis factor-transgenic (TNF-Tg) mice were used to evaluate the therapeutic effects of DGNTT on arthritis and cardiopulmonary complications. Methotrexate (MTX) served as a positive control. Histopathological assessment of the joint sections was performed using hematoxylin and eosin (H&E), Alcian Blue/Orange G (ABOG), and tartrate-resistant acid phosphatase (TRAP) staining. Bone mass was assessed by micro-computed tomography (CT), inflammatory infiltrates in the heart and lungs were evaluated by H&E staining, cardiopulmonary fibrotic injury was identified by Masson’s trichrome staining, and hypertrophy of mouse cardiomyocytes was measured by wheat germ agglutinin (WGA) staining. Results: DGNTT mitigated the inflammation of the ankle joint synovium, decreased the number of osteoclasts, and increased the area of cartilage and bone mass in TNF-Tg mice. In addition, DGNTT decreased the infiltration of inflammatory cells into the lung and heart tissues, accompanied by a reduction in cardiopulmonary fibrosis and myocardial cell hypertrophy in TNF-Tg mice. As a positive control drug, MTX attenuated the pathological changes in joints, but had no beneficial effect on cardiopulmonary inflammation and fibrosis in TNF-Tg mice. Conclusion: DGNTT improved joint lesions and alleviated cardiopulmonary complications in TNF-Tg mice.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136059810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-28DOI: 10.1097/hm9.0000000000000078
Longlong Gao, Lijun Hao, Wenjie Xu, Tianyi Xin, Chi Song, Yulin Lin, Lingping Zhu, Jingyuan Song
Objective: This work aimed to report the first complete mitochondrial genome (mitogenome) of Rheum palmatum , summarize the features of Caryophyllales mitogenomes and to reveal the potential of utilizing the mitogenomes of R. palmatum and other Caryophyllales species for inferring phylogenetic relationships and species identification. Methods: Both Illumina short reads and PacBio HiFi reads were utilized to obtain a complete mitogenome of R. palmatum . A variety of bioinformatics tools were employed to characterize the R. palmatum mitogenome, compare the reported mitogenomes in Caryophyllales and conduct phylogenetic analysis. Results: The mitogenome of R. palmatum was assembled into a single master circle of 302,993 bp, encoding 35 known protein-coding genes, 18 tRNA genes and 3 rRNA genes. A total of 249 long repeats and 49 SSRs were identified in this mitogenome. The sizes of mitogenomes in Caryophyllales varied from 253 kb to 11.3 Mb. Among them, twenty-three mitogenomes were circular molecules, one was linear, and one consisted of relaxed circles, linear molecules, and supercoiled DNA. Out of the total mitogenomes, eleven were single-chromosome structure, while the remaining fourteen were multi-chromosomal organizations. The phylogenetic analysis is consistent with both the Engler system (1964) and the Angiosperm Phylogeny Group III (APG III) system. Conclusions: We obtained the first mitogenome of R. palmatum , which consists of a master circle. Mitogenomes in Caryophyllales have variable genome sizes and structures even within the same species. Circular molecules are still the dominant pattern in Caryophyllales. Single-chromosome mitogenomes account for nearly a half of all the mitogenomes in Caryophyllales, in contrast to previous studies. It is feasible to utilize mitochondrial genomes for inferring phylogenetic relationships and conducting species identification.
目的:报道掌叶大黄(Rheum掌叶大黄)首个线粒体全基因组(有丝分裂基因组)，总结掌叶大黄有丝分裂基因组的特征，揭示掌叶大黄与其他石竹属植物有丝分裂基因组在推测系统发育关系和物种鉴定方面的潜力。方法:利用Illumina short reads和PacBio HiFi reads获得掌叶切蝇的完整有丝分裂基因组。利用多种生物信息学工具对棕榈有丝分裂基因组进行了表征，比较了已报道的石竹科植物有丝分裂基因组，并进行了系统发育分析。结果:掌叶裂丝基因组组装成一个302993 bp的主环，编码35个已知蛋白编码基因、18个tRNA基因和3个rRNA基因。在该有丝分裂基因组中共鉴定出249个长重复序列和49个SSRs。石香树有丝分裂基因组的大小从253 kb到11.3 Mb不等，其中23个有丝分裂基因组为圆形分子，1个为线性分子，1个由松弛圆、线性分子和超卷曲DNA组成。有丝分裂基因组中有11个为单染色体结构，其余14个为多染色体结构。系统发育分析与Engler系统(1964)和被子植物系统发育类群III (APG III)系统一致。结论:获得了掌叶鼠的第一个有丝分裂基因组，该基因组由一个主环组成。石竹属植物的有丝分裂基因组即使在同一物种中也具有不同的基因组大小和结构。圆形分子仍是石竹属植物的主要结构。与以往的研究相比，单染色体有丝分裂基因组占石蕊类所有有丝分裂基因组的近一半。利用线粒体基因组推断系统发育关系和进行物种鉴定是可行的。
{"title":"Characterization of Rheum palmatum mitochondrial genome and comparative analysis among Caryophyllales species","authors":"Longlong Gao, Lijun Hao, Wenjie Xu, Tianyi Xin, Chi Song, Yulin Lin, Lingping Zhu, Jingyuan Song","doi":"10.1097/hm9.0000000000000078","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000078","url":null,"abstract":"Objective: This work aimed to report the first complete mitochondrial genome (mitogenome) of Rheum palmatum , summarize the features of Caryophyllales mitogenomes and to reveal the potential of utilizing the mitogenomes of R. palmatum and other Caryophyllales species for inferring phylogenetic relationships and species identification. Methods: Both Illumina short reads and PacBio HiFi reads were utilized to obtain a complete mitogenome of R. palmatum . A variety of bioinformatics tools were employed to characterize the R. palmatum mitogenome, compare the reported mitogenomes in Caryophyllales and conduct phylogenetic analysis. Results: The mitogenome of R. palmatum was assembled into a single master circle of 302,993 bp, encoding 35 known protein-coding genes, 18 tRNA genes and 3 rRNA genes. A total of 249 long repeats and 49 SSRs were identified in this mitogenome. The sizes of mitogenomes in Caryophyllales varied from 253 kb to 11.3 Mb. Among them, twenty-three mitogenomes were circular molecules, one was linear, and one consisted of relaxed circles, linear molecules, and supercoiled DNA. Out of the total mitogenomes, eleven were single-chromosome structure, while the remaining fourteen were multi-chromosomal organizations. The phylogenetic analysis is consistent with both the Engler system (1964) and the Angiosperm Phylogeny Group III (APG III) system. Conclusions: We obtained the first mitogenome of R. palmatum , which consists of a master circle. Mitogenomes in Caryophyllales have variable genome sizes and structures even within the same species. Circular molecules are still the dominant pattern in Caryophyllales. Single-chromosome mitogenomes account for nearly a half of all the mitogenomes in Caryophyllales, in contrast to previous studies. It is feasible to utilize mitochondrial genomes for inferring phylogenetic relationships and conducting species identification.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135343198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Inhibition of tumor angiogenesis has become a new targeted tumor therapy. In this study, we established a micellar carrier with a tumor neovascularization-targeting effect modified by the neovascularization-targeting peptide NGR. Methods: The targeted polymer NGR-PEG-PLGA was prepared and characterized by 1 H nuclear magnetic resonance and Fourier-transform infrared spectrometry. NGR-PEG-PLGA was used to construct curcumin-loaded micelles by the solvent-evaporation method. The physicochemical properties of the micelles were also investigated. Additionally, we evaluated the antitumor efficacy of the polymer micelles using in vitro cytology experiments and in vivo animal studies. Results: The particle size of Cur-NGR-PM was 139.70±2.51 nm, and the drug-loading capacity was 14.37±0.06%. In vitro cytological evaluation showed that NGR-modified micelles showed higher cellular uptake through receptor-mediated endocytosis pathways than did unmodified micelles, leading to the apoptosis of tumor cells. Then, in vivo antitumor experiments showed that the modified micelles significantly inhibited tumor growth and were safe. Conclusions: NGR-modified micelles significantly optimized the therapeutic efficacy of curcumin. This strategy offers a viable avenue for cancer treatment.
{"title":"Construction of curcumin-loaded micelles and evaluation of the antitumor effect based on angiogenesis","authors":"Rui Liu, Zhongyan Liu, Changxiang Yu, Ying Zhang, Xiaojiao Feng, Qingqing Zhang, Wenli Dang, Xintao Jia, Bei Jia, Jiachen He, Bin Xing, Ziwei Li, Huihui Li, Xueli Guo, Dereje Kebebe, Jiaxin Pi, Pan Guo","doi":"10.1097/hm9.0000000000000079","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000079","url":null,"abstract":"Objective: Inhibition of tumor angiogenesis has become a new targeted tumor therapy. In this study, we established a micellar carrier with a tumor neovascularization-targeting effect modified by the neovascularization-targeting peptide NGR. Methods: The targeted polymer NGR-PEG-PLGA was prepared and characterized by 1 H nuclear magnetic resonance and Fourier-transform infrared spectrometry. NGR-PEG-PLGA was used to construct curcumin-loaded micelles by the solvent-evaporation method. The physicochemical properties of the micelles were also investigated. Additionally, we evaluated the antitumor efficacy of the polymer micelles using in vitro cytology experiments and in vivo animal studies. Results: The particle size of Cur-NGR-PM was 139.70±2.51 nm, and the drug-loading capacity was 14.37±0.06%. In vitro cytological evaluation showed that NGR-modified micelles showed higher cellular uptake through receptor-mediated endocytosis pathways than did unmodified micelles, leading to the apoptosis of tumor cells. Then, in vivo antitumor experiments showed that the modified micelles significantly inhibited tumor growth and were safe. Conclusions: NGR-modified micelles significantly optimized the therapeutic efficacy of curcumin. This strategy offers a viable avenue for cancer treatment.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136011704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acupuncture, a form of traditional Chinese medicine with a history of 2000 years in China, has gained wider acceptance worldwide as a complementary therapy. Studies have examined its effectiveness in various health conditions and it is commonly used alongside conventional medical treatments. With the development of artificial intelligence (AI) technology, new possibilities for improving the efficacy and precision of acupuncture have emerged. This study explored the combination of traditional acupuncture and AI technology from three perspectives: acupuncture diagnosis, prescription, and treatment evaluation. The study aimed to provide cutting-edge direction and theoretical assistance for the development of an acupuncture robot.
{"title":"Intelligent Acupuncture: Data-driven Revolution of Traditional Chinese Medicine","authors":"Yunfan Bao, Haokang Ding, Zhihan Zhang, Kunhuan Yang, Queena Tran, Qi Sun, Tiancheng Xu","doi":"10.1097/hm9.0000000000000077","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000077","url":null,"abstract":"Acupuncture, a form of traditional Chinese medicine with a history of 2000 years in China, has gained wider acceptance worldwide as a complementary therapy. Studies have examined its effectiveness in various health conditions and it is commonly used alongside conventional medical treatments. With the development of artificial intelligence (AI) technology, new possibilities for improving the efficacy and precision of acupuncture have emerged. This study explored the combination of traditional acupuncture and AI technology from three perspectives: acupuncture diagnosis, prescription, and treatment evaluation. The study aimed to provide cutting-edge direction and theoretical assistance for the development of an acupuncture robot.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135885589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1097/hm9.0000000000000072
{"title":"Effects of acupuncture on angiogenesis associated factor expression in ischemic brain tissue following cerebral infarction in rats: Erratum","authors":"","doi":"10.1097/hm9.0000000000000072","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000072","url":null,"abstract":"","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2023-09-29DOI: 10.1097/HM9.0000000000000073
[This corrects the article DOI: 10.1097/HM9.0000000000000030.].
[这更正了文章DOI:10.1097/HM9.0000000000000030.]。
{"title":"Erratum: Analysis on the medication rule of traditional Chinese medicine in the treatment of COVID-19 patients: Erratum.","authors":"","doi":"10.1097/HM9.0000000000000073","DOIUrl":"10.1097/HM9.0000000000000073","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/HM9.0000000000000030.].</p>","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/0d/hm9-3-227.PMC10563385.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicinal plants are renowned for their abundant production of secondary metabolites, which exhibit notable pharmacological activities and great potential for drug development. The biosynthesis of secondary metabolites is highly intricate and influenced by various intrinsic and extrinsic factors, resulting in substantial species diversity and content variation. Consequently, precise regulation of secondary metabolite synthesis is of utmost importance. In recent years, genome sequencing has emerged as a valuable tool for investigating the synthesis and regulation of secondary metabolites in medicinal plants, facilitated by the widespread use of high-throughput sequencing technologies. This review highlights the latest advancements in genome sequencing within this field and presents several strategies for studying secondary metabolites. Specifically, the article elucidates how genome sequencing can unravel the pathways for secondary-metabolite synthesis in medicinal plants, offering insights into the functions and regulatory mechanisms of participating enzymes. Comparative analyses of plant genomes allow identification of shared pathways of metabolite synthesis among species, thereby providing novel avenues for obtaining cost-effective biosynthetic intermediates. By examining individual genomic variations, genes or gene clusters associated with the synthesis of specific compounds can be discovered, indicating potential targets and directions for drug development and the exploration of alternative compound sources. Moreover, the advent of gene-editing technology has enabled the precise modifications of medicinal plant genomes. Optimization of specific secondary metabolite synthesis pathways becomes thus feasible, enabling the precise editing of target genes to regulate secondary metabolite production within cells. These findings serve as valuable references and lessons for future drug development endeavors, conservation of rare resources, and the exploration of new resources.
{"title":"Genome sequencing provides potential strategies for drug discovery and synthesis","authors":"Chunsheng Zhao, Ziwei Zhang, Linlin Sun, Rong Bai, Lizhi Wang, Shilin Chen","doi":"10.1097/hm9.0000000000000076","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000076","url":null,"abstract":"Medicinal plants are renowned for their abundant production of secondary metabolites, which exhibit notable pharmacological activities and great potential for drug development. The biosynthesis of secondary metabolites is highly intricate and influenced by various intrinsic and extrinsic factors, resulting in substantial species diversity and content variation. Consequently, precise regulation of secondary metabolite synthesis is of utmost importance. In recent years, genome sequencing has emerged as a valuable tool for investigating the synthesis and regulation of secondary metabolites in medicinal plants, facilitated by the widespread use of high-throughput sequencing technologies. This review highlights the latest advancements in genome sequencing within this field and presents several strategies for studying secondary metabolites. Specifically, the article elucidates how genome sequencing can unravel the pathways for secondary-metabolite synthesis in medicinal plants, offering insights into the functions and regulatory mechanisms of participating enzymes. Comparative analyses of plant genomes allow identification of shared pathways of metabolite synthesis among species, thereby providing novel avenues for obtaining cost-effective biosynthetic intermediates. By examining individual genomic variations, genes or gene clusters associated with the synthesis of specific compounds can be discovered, indicating potential targets and directions for drug development and the exploration of alternative compound sources. Moreover, the advent of gene-editing technology has enabled the precise modifications of medicinal plant genomes. Optimization of specific secondary metabolite synthesis pathways becomes thus feasible, enabling the precise editing of target genes to regulate secondary metabolite production within cells. These findings serve as valuable references and lessons for future drug development endeavors, conservation of rare resources, and the exploration of new resources.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88464294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.1097/HM9.0000000000000075
Qingquan Li, J. Wan, Lu Zhao
Senkyunolides are a group of phthalide molecules that exist in Umbelliferae plants, with the highest abundance in Ligusticum chuanxiong Hort, a medicinal herb with therapeutic applications in various diseases such as coronary heart disease, migraine, and rheumatism. Modern research has highlighted the anti-inflammatory, analgesic, and cardiovascular-protective properties of senkyunolides. Recently, some novel effects, such as antibacterial, anti-osteoporosis, and anti-fibrosis, have been reported for senkyunolides, indicating their diverse biological activities. In addition, because of its high bioavailability and ability to cross the blood-brain barrier (BBB), particularly exemplified by senkyunolide I (SEI), holds promise for the treatment of brain diseases. Multiple signaling pathways have been related to the pharmacological activities of senkyunolides, such as the toll-like receptor 4/nuclear factor-kappa B (NF-κB) signaling, extracellular signal–regulated kinase (ERK) pathway, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase (JNK) pathways. Here, we review the research progress on the pharmacokinetics and pharmacological effects of senkyunolides, which are promising candidates for future drug development and have significant clinical value in the treatment of various diseases. Graphical abstract: http://links.lww.com/AHM/A66.
Senkyunolides是一类存在于伞科植物中的苯酞类分子，在川芎中含量最高，是一种治疗冠心病、偏头痛、风湿病等多种疾病的中药。现代研究强调了神仙内酯的抗炎、镇痛和心血管保护特性。近年来，一些新的药理作用如抗菌、抗骨质疏松、抗纤维化等被报道，表明其具有丰富的生物学活性。此外，由于其高生物利用度和穿越血脑屏障(BBB)的能力，特别是senkyunolide I (SEI)，有望用于脑部疾病的治疗。多种信号通路与仙球内酯的药理活性有关，如toll样受体4/核因子κB (NF-κB)信号通路、细胞外信号调节激酶(ERK)通路、p38丝裂原活化蛋白激酶和c-Jun n-末端激酶(JNK)通路。本文就仙球内酯类药物的药代动力学和药理作用的研究进展进行综述，认为仙球内酯类药物是未来药物开发的重要候选药物，在治疗多种疾病方面具有重要的临床价值。图形摘要:http://links.lww.com/AHM/A66。
{"title":"Research progress on the pharmacological activities of senkyunolides","authors":"Qingquan Li, J. Wan, Lu Zhao","doi":"10.1097/HM9.0000000000000075","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000075","url":null,"abstract":"Senkyunolides are a group of phthalide molecules that exist in Umbelliferae plants, with the highest abundance in Ligusticum chuanxiong Hort, a medicinal herb with therapeutic applications in various diseases such as coronary heart disease, migraine, and rheumatism. Modern research has highlighted the anti-inflammatory, analgesic, and cardiovascular-protective properties of senkyunolides. Recently, some novel effects, such as antibacterial, anti-osteoporosis, and anti-fibrosis, have been reported for senkyunolides, indicating their diverse biological activities. In addition, because of its high bioavailability and ability to cross the blood-brain barrier (BBB), particularly exemplified by senkyunolide I (SEI), holds promise for the treatment of brain diseases. Multiple signaling pathways have been related to the pharmacological activities of senkyunolides, such as the toll-like receptor 4/nuclear factor-kappa B (NF-κB) signaling, extracellular signal–regulated kinase (ERK) pathway, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase (JNK) pathways. Here, we review the research progress on the pharmacokinetics and pharmacological effects of senkyunolides, which are promising candidates for future drug development and have significant clinical value in the treatment of various diseases. Graphical abstract: http://links.lww.com/AHM/A66.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90776522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-10DOI: 10.1097/hm9.0000000000000074
Yingying Shao, Ranran Su, Yu Wang, Shuangshuang Yin, Wei-Ling Pu, S. Koo, Haiyang Yu
The etiology and exact molecular mechanisms of primary hepatocellular carcinoma (HCC) remain unclear, and its incidence has continued to increase in recent years. Despite tremendous advances in systemic therapies such as molecularly targeted drugs, HCC has some of the worst prognoses owing to drug resistance, frequent recurrence, and metastasis. Hepatocellular carcinoma is a widespread disease and its progression is regulated by the immune system. Traditional Chinese medicine (TCM) has been gradually theorized and systematized to have a holistic regulatory role for use in the prevention and treatment of tumors. Although half of the patients with HCC receive systemic therapy, traditionally Sorafenib or Lenvatinib are used as first-line treatment modalities. Traditional Chinese Medicine is also widely used in the treatment of HCC, the same immune checkpoint inhibitors (ICIs) such as PD-L1 have also received much focus in the field of continuously changing cancer treatment. Owing to the high probability of resistance to specific drugs and unsatisfactory efficacy due to administration of chemotherapy in single doses, the combination of drugs is the newest therapeutic option for patients with tumors and has become increasingly prominent for treatment. In this paper, the research progress on combination therapy in the immunology of HCC is reviewed and the unique advantages of synergistic antitumor therapy with combination drugs are highlighted to provide new solutions for the clinical treatment of tumors.
{"title":"Drug co-administration in the HCC tumor immune microenvironment","authors":"Yingying Shao, Ranran Su, Yu Wang, Shuangshuang Yin, Wei-Ling Pu, S. Koo, Haiyang Yu","doi":"10.1097/hm9.0000000000000074","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000074","url":null,"abstract":"The etiology and exact molecular mechanisms of primary hepatocellular carcinoma (HCC) remain unclear, and its incidence has continued to increase in recent years. Despite tremendous advances in systemic therapies such as molecularly targeted drugs, HCC has some of the worst prognoses owing to drug resistance, frequent recurrence, and metastasis. Hepatocellular carcinoma is a widespread disease and its progression is regulated by the immune system. Traditional Chinese medicine (TCM) has been gradually theorized and systematized to have a holistic regulatory role for use in the prevention and treatment of tumors. Although half of the patients with HCC receive systemic therapy, traditionally Sorafenib or Lenvatinib are used as first-line treatment modalities. Traditional Chinese Medicine is also widely used in the treatment of HCC, the same immune checkpoint inhibitors (ICIs) such as PD-L1 have also received much focus in the field of continuously changing cancer treatment. Owing to the high probability of resistance to specific drugs and unsatisfactory efficacy due to administration of chemotherapy in single doses, the combination of drugs is the newest therapeutic option for patients with tumors and has become increasingly prominent for treatment. In this paper, the research progress on combination therapy in the immunology of HCC is reviewed and the unique advantages of synergistic antitumor therapy with combination drugs are highlighted to provide new solutions for the clinical treatment of tumors.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74241102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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