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Does the Superior Septal Approach Increase the Incidence of Postoperative Junctional Rhythm Compared to the Right-Sided Left Atriotomy?: A Comparison in Minimally Invasive Mitral Valve Surgery via Right Mini-Thoracotomy. 与右侧左心房切开术相比,上间隔入路是否会增加术后连接节律的发生率?右小开胸微创二尖瓣手术的比较。
Masataka Yamazaki, Yorihiko Matsumoto, Tatsuo Takahashi, Hirofumi Haida, Naritaka Kimura, Kenichi Hashizume, Hideyuki Shimizu

Purpose: The superior septal approach offers improved mitral valve exposure compared to the right-sided left atriotomy or transseptal approach. However, the risk of postoperative sinus node dysfunction remains controversial, with limited data in the context of right mini-thoracotomy.

Methods: This retrospective study included 155 patients (64 women; mean age, 60.8 ± 13.4 years) who underwent mitral valve surgery via right mini-thoracotomy between November 2016 and August 2023. Indications included degenerative mitral regurgitation (94.8%) and mitral stenosis (5.2%). Patients were divided into 2 groups: the conventional minimally invasive mitral valve surgery (CM) group (n = 47), using the right-sided left atriotomy, and the drawer-case technique (DCT) group (n = 108), using the superior septal approach. Demographic, intraoperative, and outcome data were analyzed.

Results: Baseline characteristics were similar between groups. There were no significant differences in valve repair techniques or postoperative echocardiographic findings. Postoperative junctional rhythm occurred in 6 patients (CM group) and 21 patients (DCT group); all patients with preoperative sinus rhythm returned to sinus rhythm postoperatively.

Conclusion: The superior septal approach does not increase the risk of persistent junctional rhythm in right mini-thoracotomy and is a safe and effective option for mitral valve surgery.

目的:与右侧左心房切开或经间隔入路相比,上间隔入路可改善二尖瓣暴露。然而,术后窦结功能障碍的风险仍然存在争议,在右侧小开胸手术的背景下,数据有限。方法:本回顾性研究纳入155例患者(女性64例;平均年龄60.8±13.4岁),于2016年11月至2023年8月期间接受了右小开胸二尖瓣手术。适应症包括退行性二尖瓣返流(94.8%)和二尖瓣狭窄(5.2%)。将患者分为两组:常规微创二尖瓣手术(CM)组(n = 47),采用右侧左心房切开术;抽屉盒技术(DCT)组(n = 108),采用上间隔入路。对人口学、术中和结局数据进行分析。结果:两组间基线特征相似。两组在瓣膜修复技术和术后超声心动图表现上无显著差异。CM组6例,DCT组21例;术前有窦性心律的患者术后均恢复窦性心律。结论:上间隔入路不会增加右小开胸术持续结节律的风险,是二尖瓣手术安全有效的选择。
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引用次数: 0
No-Touch Saphenous Vein Graft for Coronary Artery Bypass Grafting. 无接触隐静脉移植在冠状动脉旁路移植术中的应用。
Min-Seok Kim, Seong Wook Hwang, Ki-Bong Kim

Compared with the conventionally harvested saphenous vein graft, the no-touch saphenous vein graft, in which manipulation and tension are minimized and intraluminal dilatation is avoided during vein harvest, has shown better-preserved luminal endothelium and improved patency rates after coronary artery bypass grafting. This review article will detail and summarize the relevant literature on the no-touch saphenous vein in coronary artery bypass grafting.

与常规隐静脉移植相比,非接触式隐静脉移植在静脉采集过程中减少了操作和张力,避免了腔内扩张,可以更好地保存腔内内皮,提高冠状动脉旁路移植术后的通畅率。本文将对冠状动脉旁路移植术中无接触隐静脉的相关文献作一综述。
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引用次数: 0
Left Atrial Mitral Valve Chordae Which Disturbed the Mitral Leaflet Motion and Induced Mitral Regurgitation. 左心房二尖瓣索,干扰二尖瓣小叶运动,诱发二尖瓣返流。
Toru Kameda, Tomohiro Mizuno, Kota Kawada, Tsubasa Yoshikawa, Koichi Sugiyama, Yuzo Katayama, Takeshiro Fujii

Left atrial mitral valve chorda (LAMVC) is a rare congenital cardiac anomaly. The abnormal tissue band, like a mitral valve chorda, is attached to the left atrial wall on one side and mostly to the mitral valve leaflet on the other side and the band sometimes disturbs the mitral leaflet motion, followed by mitral regurgitation (MR). We encountered a case with a LAMVC which originated from a papillary muscle and attached to the posterior mitral annulus over the posterior leaflet and caused MR due to restricted mitral leaflet motion.

左心房二尖瓣腱索(LAMVC)是一种罕见的先天性心脏畸形。异常组织带就像二尖瓣腱索一样,一侧附着在左心房壁上,另一侧主要附着在二尖瓣瓣叶上,有时会干扰二尖瓣瓣叶运动,继而导致二尖瓣反流(MR)。我们曾遇到过一例 LAMVC 病例,其源于乳头肌,附着在二尖瓣环后叶上方,由于二尖瓣叶运动受限而导致二尖瓣反流。
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引用次数: 0
Perioperative Treatment of Metachronous Multiple Lung Cancer with Organizing Pneumonia: A Case Report. 异时性多发性肺癌伴组织性肺炎围手术期治疗1例。
Hiroshi Takehara, Ken Kodama, Toru Momozane, Kansuke Kido

We report a rare case of the independent coexistence of lung cancer and organizing pneumonia (OP) in different lobes of the right lung in a 67-year-old man with a history of left upper lobectomy. Computed tomography revealed a lesion consistent with OP in the right upper lobe and a suspicious shadow in the right lower lobe, which was diagnosed as squamous cell carcinoma via bronchoscopic biopsy. The patient underwent right lower lobectomy and partial resection of the right upper lobe under left one-lung ventilation. Empirical corticosteroids were administered preoperatively, followed by a brief postoperative course for 3 days after pathological confirmation of OP to reduce complications such as bronchial fistula, then transitioned to macrolide therapy for 3 months. Fourteen months postoperatively, OP had not recurred, although bone metastases developed and responded well to chemoradiotherapy. This case highlights the need for individualized perioperative management in patients with complex pulmonary pathology.

我们报告一个罕见的病例独立共存肺癌和组织性肺炎(OP)在不同的肺叶右肺67岁的男性与左上肺叶切除术的历史。ct示右上肺叶病变符合OP,右下肺叶可疑影,支气管镜活检诊断为鳞状细胞癌。患者在左单肺通气下行右下肺叶切除术和部分右上肺叶切除术。术前给予经年性皮质类固醇,术后病理确认OP后短暂疗程3天,以减少支气管瘘等并发症,然后过渡到大环内酯治疗3个月。术后14个月,OP没有复发,尽管出现骨转移并且对放化疗反应良好。本病例强调了对复杂肺部病理患者进行个体化围手术期管理的必要性。
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引用次数: 0
Usefulness of Artificial Pneumothorax during Totally Endoscopic Off-Pump Left Atrial Appendage Closure and Surgical Ablation. 人工气胸在全内镜下无泵左心耳闭合和手术消融中的应用。
Shunsuke Sato, Takashi Azami, Jun Fujisue, Kyozo Inoue, Kenji Okada

Purpose: In totally endoscopic off-pump left atrial appendage (LAA) closure and surgical ablation, securing the operative field is sometimes difficult in some patients because of a narrow working space caused by an elevated diaphragm or ventricles. In this study, we aimed to investigate the effectiveness of a method that facilitates securing the operative field using an artificial pneumothorax.

Methods: We analyzed 71 consecutive patients who underwent totally endoscopic off-pump LAA closure and bilateral pulmonary vein isolation. The factors contributing to the reduction in operative time were examined. The patients were divided into the following 2 groups according to whether or not an artificial pneumothorax was used: Group C comprised 24 patients without an artificial pneumothorax and Group A comprised 47 patients with an artificial pneumothorax.

Results: There were no hospital deaths or major complications. The operative time was significantly shorter in Group A (108 ± 26 minutes) than in Group C (198 ± 77 minutes) (p <0.0001).

Conclusions: In totally endoscopic off-pump LAA closure and surgical ablation, an artificial pneumothorax may be useful in reducing the operative time.

目的:在全内镜下无泵左心耳(LAA)关闭和手术消融中,由于膈或心室升高导致的工作空间狭窄,某些患者有时难以固定手术野。在本研究中,我们旨在探讨一种使用人工气胸保护手术野的方法的有效性。方法:我们分析了71例连续接受全内窥镜下泵外LAA闭合和双侧肺静脉隔离的患者。研究了减少手术时间的因素。根据是否使用人工气胸分为两组:C组无人工气胸24例,A组有人工气胸47例。结果:无院内死亡及重大并发症。A组的手术时间(108±26分钟)明显短于C组(198±77分钟)。(p)结论:在完全内镜下关闭LAA并手术消融的情况下,人工气胸可能有助于缩短手术时间。
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引用次数: 0
Delayed Diagnosis of Primary Pulmonary Sarcoma Arising from a Pulmonary Cyst in an Adult: A Case Report. 成人肺囊肿引起的原发性肺肉瘤的延迟诊断1例报告。
Yoshito Imamura, Taketo Kato, Satoko Shimada, Harushi Ueno, Shota Nakamura, Tetsuya Mizuno, Toyofumi Fengshi Chen-Yoshikawa

Primary pulmonary sarcoma is a rare disease and is much less common than lung cancer among tumors arising from pulmonary cysts. We report the case of a female patient who showed multifocal cysts in the left S9-10. Follow-up computed tomography (CT) revealed that the cyst tended to regress, but the solid component of the cyst wall continued to thicken, growing to a 10-cm-diameter tumor. Thoracoscopic left lower lobectomy was performed to diagnose and treat the cystic lung lesions. For the pathology of the pulmonary cystic lesion, it was marked by solid tumors composed of proliferative atypical spindle cells, with some trapped bronchial tissue. Based on the imaging and pathological findings, the diagnosis was primary pulmonary sarcoma arising from the pulmonary cyst. The present case highlights that, even when a pulmonary cyst appears to shrink, careful follow-up and timely surgical consideration are warranted if cyst wall thickening is observed.

原发性肺肉瘤是一种罕见的疾病,在由肺囊肿引起的肿瘤中,其发病率远低于肺癌。我们报告一例女性患者在左侧S9-10表现出多灶性囊肿。随访CT显示囊肿有消退的趋势,但囊肿壁实性成分继续增厚,长成直径10 cm的肿瘤。行胸腔镜下左下肺叶切除术诊断和治疗肺囊性病变。肺囊性病变病理表现为非典型梭形细胞增生组成的实体瘤,伴支气管组织被困。根据影像学和病理表现,诊断为原发性肺肉瘤,起源于肺囊肿。本病例强调,即使出现肺囊肿缩小,如果观察到囊肿壁增厚,也应仔细随访并及时进行手术治疗。
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引用次数: 0
Eight-Year Clinical Outcomes of Transcatheter Aortic Valve Replacement with J-Valve System. j -瓣膜系统经导管主动脉瓣置换术8年临床疗效观察
Fei Li, Yuetang Wang, Donghui Xu, Xu Wang, Wei Wang

Purpose: This study aimed to summarize 8-year clinical outcomes for patients who underwent transcatheter aortic valve replacement (TAVR) with the J-Valve system and evaluate the long-term durability and hemodynamic performance of the valve.

Methods: Between July 2014 and June 2015, 21 patients underwent transapical TAVR with the J-Valve system. Systematic clinical and echocardiographic follow-up was conducted on 18 patients for up to 8 years.

Results: Eight years post-TAVR with the J-Valve system, the all-cause mortality rate was 16.7%, with no prosthesis failures or thrombosis. Moderate to severe valve deterioration was observed in 50% of patients with aortic stenosis (AS), whereas no such deterioration was noted in patients with pure aortic regurgitation (PAR). At 8 years following TAVR, the effective orifice area measured 2.27 ± 0.50 cm2 in patients with PAR and 1.35 ± 0.38 cm2 in those with AS. Additionally, patients with AS exhibited a mean pressure gradient of 17.90 ± 10.61 mmHg. Over 8 years, PAR patients experienced a significant reduction in left ventricular end-diastolic diameter from 61.50 ± 2.08 mm to 48.67 ± 7.23 mm (p < 0.001), whereas AS patients showed no significant change.

Conclusion: The J-Valve system demonstrates favorable long-term outcomes in TAVR, with excellent durability and hemodynamic performance in PAR patients.

目的:本研究旨在总结经导管J-Valve系统主动脉瓣置换术(TAVR)患者8年的临床结果,并评估瓣膜的长期耐久性和血流动力学性能。方法:2014年7月至2015年6月,21例患者行J-Valve系统经根尖TAVR。对18例患者进行了系统的临床和超声心动图随访,随访时间长达8年。结果:J-Valve系统tavr术后8年全因死亡率为16.7%,无假体失效或血栓形成。50%的主动脉瓣狭窄(AS)患者出现中度至重度瓣膜恶化,而单纯主动脉瓣返流(PAR)患者没有出现这种恶化。在TAVR后8年,PAR患者的有效孔面积为2.27±0.50 cm2, AS患者的有效孔面积为1.35±0.38 cm2。此外,AS患者的平均压力梯度为17.90±10.61 mmHg。8年后,PAR患者左室舒张末期直径从61.50±2.08 mm显著降低至48.67±7.23 mm (p < 0.001),而AS患者无显著变化。结论:J-Valve系统在TAVR患者中具有良好的长期疗效,在PAR患者中具有良好的耐久性和血流动力学性能。
{"title":"Eight-Year Clinical Outcomes of Transcatheter Aortic Valve Replacement with J-Valve System.","authors":"Fei Li, Yuetang Wang, Donghui Xu, Xu Wang, Wei Wang","doi":"10.5761/atcs.oa.24-00152","DOIUrl":"https://doi.org/10.5761/atcs.oa.24-00152","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to summarize 8-year clinical outcomes for patients who underwent transcatheter aortic valve replacement (TAVR) with the J-Valve system and evaluate the long-term durability and hemodynamic performance of the valve.</p><p><strong>Methods: </strong>Between July 2014 and June 2015, 21 patients underwent transapical TAVR with the J-Valve system. Systematic clinical and echocardiographic follow-up was conducted on 18 patients for up to 8 years.</p><p><strong>Results: </strong>Eight years post-TAVR with the J-Valve system, the all-cause mortality rate was 16.7%, with no prosthesis failures or thrombosis. Moderate to severe valve deterioration was observed in 50% of patients with aortic stenosis (AS), whereas no such deterioration was noted in patients with pure aortic regurgitation (PAR). At 8 years following TAVR, the effective orifice area measured 2.27 ± 0.50 cm<sup>2</sup> in patients with PAR and 1.35 ± 0.38 cm<sup>2</sup> in those with AS. Additionally, patients with AS exhibited a mean pressure gradient of 17.90 ± 10.61 mmHg. Over 8 years, PAR patients experienced a significant reduction in left ventricular end-diastolic diameter from 61.50 ± 2.08 mm to 48.67 ± 7.23 mm (p < 0.001), whereas AS patients showed no significant change.</p><p><strong>Conclusion: </strong>The J-Valve system demonstrates favorable long-term outcomes in TAVR, with excellent durability and hemodynamic performance in PAR patients.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterior Leaflet Overlay Patch Reinforcement for Mitral Valve Posterior Tethering: The Elbow Patch Repair. 后侧小叶覆盖补片加固二尖瓣后栓:肘关节补片修复。
Hyeon A Kim, Jae Suk Yoo

The scarcity of leaflet tissue and restricted systolic motion remain challenges in mitral valve repair. In addition to functional or secondary mitral regurgitation, atrial functional mitral regurgitation, characterized by chronic atrial fibrillation, preserved left ventricular function, and atriogenic leaflet tethering, exacerbates leaflet scarcity, complicating mitral valve repair. To address this, we introduce the "elbow patch repair," a novel technique using an autologous pericardium overlay patch to reinforce the posterior mitral valve leaflet. A 65-year-old male patient with chronic atrial fibrillation and severe mitral regurgitation consistent with atrial functional mitral regurgitation underwent the "elbow patch repair" combined with annuloplasty and neochordae placement. This approach effectively managed posterior mitral valve leaflet deficiency and restored the coaptation surface. The "elbow patch repair" offers a straightforward and effective solution for leaflet shortage in atrial functional mitral regurgitation and select cases of Carpentier Class IIIb. Further studies are needed to assess its long-term durability.

小叶组织的缺乏和收缩运动受限仍然是二尖瓣修复的挑战。除了功能性或继发性二尖瓣反流外,心房功能性二尖瓣反流以慢性心房颤动、左心室功能保留和房源性小叶栓系为特征,加剧了小叶稀缺,使二尖瓣修复复杂化。为了解决这个问题,我们介绍了“肘关节补片修复”,这是一种使用自体心包覆盖补片加强二尖瓣后叶的新技术。一例65岁男性慢性心房纤颤合并严重二尖瓣反流,符合心房功能性二尖瓣反流的患者行“肘关节补片修复”联合环成形术和新脊索置入术。该入路有效地处理了后二尖瓣小叶缺损,恢复了配合面。“肘部补片”是解决心房功能性二尖瓣反流和部分卡彭迪埃ⅲ类病例小叶不足的一种简单有效的方法。需要进一步的研究来评估其长期耐久性。
{"title":"Posterior Leaflet Overlay Patch Reinforcement for Mitral Valve Posterior Tethering: The Elbow Patch Repair.","authors":"Hyeon A Kim, Jae Suk Yoo","doi":"10.5761/atcs.nm.25-00068","DOIUrl":"10.5761/atcs.nm.25-00068","url":null,"abstract":"<p><p>The scarcity of leaflet tissue and restricted systolic motion remain challenges in mitral valve repair. In addition to functional or secondary mitral regurgitation, atrial functional mitral regurgitation, characterized by chronic atrial fibrillation, preserved left ventricular function, and atriogenic leaflet tethering, exacerbates leaflet scarcity, complicating mitral valve repair. To address this, we introduce the \"elbow patch repair,\" a novel technique using an autologous pericardium overlay patch to reinforce the posterior mitral valve leaflet. A 65-year-old male patient with chronic atrial fibrillation and severe mitral regurgitation consistent with atrial functional mitral regurgitation underwent the \"elbow patch repair\" combined with annuloplasty and neochordae placement. This approach effectively managed posterior mitral valve leaflet deficiency and restored the coaptation surface. The \"elbow patch repair\" offers a straightforward and effective solution for leaflet shortage in atrial functional mitral regurgitation and select cases of Carpentier Class IIIb. Further studies are needed to assess its long-term durability.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Series of Blowhole Creation with or without Negative Pressure Wound Therapy for Severe Subcutaneous Emphysema. 造气孔加或不加负压创面治疗严重皮下肺气肿的病例系列。
Toshiko Kamata, Shigetoshi Yoshida, Yuki Hirai, Ryo Karita, Yuki Onozato, Hironobu Wada, Takashi Anayama

Severe subcutaneous emphysema that is refractory to chest tube drainage can result in significant patient discomfort, airway compromise, and hemodynamic instability. Various interventional approaches, including subcutaneous drain insertion and the blowhole technique, with or without negative pressure wound therapy (NPWT), have been proposed to manage this condition. In this case series, we describe 10 patients who developed severe subcutaneous emphysema following surgery or pneumothorax and were treated using the blowhole technique, with or without NPWT. A Wound Protector/Retractor XXS or LapProtector was used to maintain the patency of the blowhole, facilitating continuous decompression. In cases with more extensive emphysema, the application of NPWT led to rapid respiratory improvement, thereby enabling additional invasive interventions to address the underlying pulmonary air leak. These findings highlight the potential utility of a structured approach incorporating NPWT for the management of severe subcutaneous emphysema, particularly in cases refractory to conventional chest tube drainage.

严重的皮下肺气肿对胸管引流有难治性,可导致患者明显不适、气道受损和血流动力学不稳定。各种介入方法,包括皮下引流插入和通气孔技术,有或没有负压伤口治疗(NPWT),已被提出来处理这种情况。在这个病例系列中,我们描述了10例在手术或气胸后出现严重皮下肺气肿的患者,并使用通气孔技术治疗,有或没有NPWT。使用伤口保护器/牵开器XXS或LapProtector保持通气孔通畅,促进持续减压。在更广泛的肺气肿病例中,NPWT的应用导致呼吸系统的快速改善,从而使额外的侵入性干预能够解决潜在的肺漏气。这些发现强调了结合NPWT的结构化方法治疗严重皮下肺气肿的潜在效用,特别是在传统胸管引流难治的病例中。
{"title":"Case Series of Blowhole Creation with or without Negative Pressure Wound Therapy for Severe Subcutaneous Emphysema.","authors":"Toshiko Kamata, Shigetoshi Yoshida, Yuki Hirai, Ryo Karita, Yuki Onozato, Hironobu Wada, Takashi Anayama","doi":"10.5761/atcs.cr.25-00034","DOIUrl":"10.5761/atcs.cr.25-00034","url":null,"abstract":"<p><p>Severe subcutaneous emphysema that is refractory to chest tube drainage can result in significant patient discomfort, airway compromise, and hemodynamic instability. Various interventional approaches, including subcutaneous drain insertion and the blowhole technique, with or without negative pressure wound therapy (NPWT), have been proposed to manage this condition. In this case series, we describe 10 patients who developed severe subcutaneous emphysema following surgery or pneumothorax and were treated using the blowhole technique, with or without NPWT. A Wound Protector/Retractor XXS or LapProtector was used to maintain the patency of the blowhole, facilitating continuous decompression. In cases with more extensive emphysema, the application of NPWT led to rapid respiratory improvement, thereby enabling additional invasive interventions to address the underlying pulmonary air leak. These findings highlight the potential utility of a structured approach incorporating NPWT for the management of severe subcutaneous emphysema, particularly in cases refractory to conventional chest tube drainage.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of In-House Cryoprecipitate Use on Transfusion Volume for Cardiopulmonary Bypass Surgery. 体外循环手术中使用低温沉淀对输血量的影响。
Wakana Niwa, Yoshiyuki Takami, Atsuo Maekawa, Koji Yamana, Kiyotoshi Akita, Kentaro Amano, Kazuki Matsuhashi, Yasushi Takagi, Tomonobu Abe

Purpose: Cryoprecipitate has been covered by Japanese national health insurance since 2020 for cardiopulmonary bypass (CPB)-induced hypofibrinogenemia. This study evaluated the clinical efficacy of in-house cryoprecipitate use in patients undergoing CPB.

Methods: A total of 1357 patients were divided into 2 groups before and after cryoprecipitate introduction in February 2020 (Group A, n = 685; Group B, n = 672). Propensity score matching also compared 205 pairs between transfused patients in Group A (Group A', n = 597) and those receiving cryoprecipitate in Group B (Group B', n = 222).

Results: Cryoprecipitate was used in 222 patients (37%) in Group B. While overall transfusion rates did not differ significantly, postoperative red blood cell (20% vs 13%, p <0.01) and platelet concentrate (PC) (35% vs 12%, p <0.01) use were significantly lower in Group B. In the matched cohorts, including ~70% undergoing aortic surgery, postoperative PC use was significantly reduced in Group B' (26% vs 18%, p = 0.04).

Conclusions: In-house cryoprecipitate use was associated with reduced postoperative PC transfusion, particularly in aortic surgery involving prolonged CPB and deep hypothermic circulatory arrest. A cryoprecipitate-centered hemostatic strategy, supplementing multiple coagulation factors beyond fibrinogen, may be effective in complex CPB procedures.

目的:自2020年以来,冷冻沉淀已被日本国民健康保险覆盖,用于体外循环(CPB)诱导的低纤维蛋白原血症。本研究评估体外冷冻沉淀在体外循环患者中的临床疗效。方法:于2020年2月将1357例患者分为引入低温沉淀前后两组(A组,n = 685; B组,n = 672)。倾向评分匹配还比较了A组(A‘组,n = 597)和B组(B’组,n = 222)输血患者的205对。结果:b组222例患者(37%)使用了cryop沉淀物,而总体输血率没有显著差异,术后红细胞(20% vs 13%) p结论:内部使用cryop沉淀物与术后PC输血减少有关,特别是在主动脉手术中涉及延长CPB和深度低温循环骤停。以低温沉淀为中心的止血策略,在纤维蛋白原之外补充多种凝血因子,可能对复杂的CPB手术有效。
{"title":"Effects of In-House Cryoprecipitate Use on Transfusion Volume for Cardiopulmonary Bypass Surgery.","authors":"Wakana Niwa, Yoshiyuki Takami, Atsuo Maekawa, Koji Yamana, Kiyotoshi Akita, Kentaro Amano, Kazuki Matsuhashi, Yasushi Takagi, Tomonobu Abe","doi":"10.5761/atcs.oa.25-00166","DOIUrl":"10.5761/atcs.oa.25-00166","url":null,"abstract":"<p><strong>Purpose: </strong>Cryoprecipitate has been covered by Japanese national health insurance since 2020 for cardiopulmonary bypass (CPB)-induced hypofibrinogenemia. This study evaluated the clinical efficacy of in-house cryoprecipitate use in patients undergoing CPB.</p><p><strong>Methods: </strong>A total of 1357 patients were divided into 2 groups before and after cryoprecipitate introduction in February 2020 (Group A, n = 685; Group B, n = 672). Propensity score matching also compared 205 pairs between transfused patients in Group A (Group A', n = 597) and those receiving cryoprecipitate in Group B (Group B', n = 222).</p><p><strong>Results: </strong>Cryoprecipitate was used in 222 patients (37%) in Group B. While overall transfusion rates did not differ significantly, postoperative red blood cell (20% vs 13%, p <0.01) and platelet concentrate (PC) (35% vs 12%, p <0.01) use were significantly lower in Group B. In the matched cohorts, including ~70% undergoing aortic surgery, postoperative PC use was significantly reduced in Group B' (26% vs 18%, p = 0.04).</p><p><strong>Conclusions: </strong>In-house cryoprecipitate use was associated with reduced postoperative PC transfusion, particularly in aortic surgery involving prolonged CPB and deep hypothermic circulatory arrest. A cryoprecipitate-centered hemostatic strategy, supplementing multiple coagulation factors beyond fibrinogen, may be effective in complex CPB procedures.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":"31 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
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