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Total Arterial Revascularization: Evaluating the Length of the Radial Artery in a Composite Graft Configuration. 全动脉血运重建:评估复合移植物配置中桡动脉的长度。
Jasmin H Shahinian, Harry Lappiere, Juan Grau, David Glineur

Purpose: Reimplanting the radial artery in the left internal thoracic artery as a composite graft allows total arterial revascularization (TAR) without aortic manipulation. The limitation of this strategy is the length of the radial artery required to reach distal right coronary artery (RCA) branches. Our analysis focuses on the feasibility of this strategy.

Methods: A total of 169 patients underwent TAR using the radial artery in a composite grafting configuration. Length of the radial artery, number of sequential anastomoses, heart size, target location, length of the arm, patient height, body surface area, and flow in the composite graft were prospectively collected.

Results: The mean length of the radial artery was 18.02 cm. Patients with a mean length of the radial artery of 15.9 cm needed an extension of the radial artery with another conduit to reach the RCA distal branches. When T-configuration is used, the length of the radial artery should be 0.53 cm per sequential anastomosis to reach the RCA distal branches.

Conclusions: Our study shows that an average length of 18.02 cm of radial artery is needed to reach targets on the RCA distal branches in composite grafting. In T-configuration, we need 0.53 cm more length per anastomosis to achieve TAR.

目的:将左胸内动脉的桡动脉作为复合移植物重新植入,可以在没有主动脉操作的情况下进行全动脉血运重建(TAR)。这种策略的局限性在于到达右冠状动脉(RCA)远端分支所需的桡动脉的长度。我们的分析重点是这一战略的可行性。方法:共有169名患者采用复合移植配置的桡动脉进行TAR。前瞻性收集桡动脉长度、顺序吻合次数、心脏大小、目标位置、手臂长度、患者身高、体表面积和复合移植物中的流量。结果:桡动脉的平均长度为18.02cm。桡动脉平均长度为15.9cm的患者需要用另一根导管延长桡动脉以到达RCA远端分支。当使用T-配置时,每次顺序吻合的桡动脉长度应为0.53cm,以到达RCA远端分支。结论:我们的研究表明,在复合移植中,平均需要18.02cm的桡动脉长度才能到达RCA远端分支上的目标。在T-构型中,我们需要每次吻合增加0.53cm的长度才能实现TAR。
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引用次数: 0
Long-Term Outcomes of Simple Endovascular Aneurysm Repair Based on the Initial Aortic Diameter. 基于初始主动脉直径的简单血管内动脉瘤修复的长期结果。
Yuki Orimoto, Hiroyuki Ishibashi, Takahiro Arima, Yusuke Imaeda, Yuki Maruyama, Hiroki Mitsuoka, Akio Kodama

Purpose: We aimed to investigate the effects of initial abdominal aortic aneurysm (AAA) diameter on aneurysmal sac expansion/shrinkage, endoleaks, and reintervention postelective simple endovascular aneurysm repair (EVAR).

Methods: Overall, 228 patients monitored for >1 year after EVAR were analyzed. Male and female participants with initial AAA diameters <55 mm and <50 mm, respectively, composed the small group (group S), while those with initial AAA diameters ≥55 mm (men) and ≥50 mm (women) composed the large group (group L). Aneurysmal sac expansion of 10 mm and/or reintervention during follow-up (composite event) and its related factors were evaluated.

Results: The 5-year freedom from composite event rate was significantly higher in group S (92.4 ± 2.8%) than that in group L (79.1 ± 4.9%; P <0.01). Multivariate analysis revealed AAA diameters before EVAR in group S (hazard ratio, 0.38; 95% confidence interval, 0.18-0.81; P = 0.01) and type II endoleak (T2EL) at discharge (hazard ratio, 2.83; 95% confidence interval, 1.29-6.20; P <0.01) as factors associated with the composite event. The freedom from composite event rate decreased to 51 ± 13% at 5 years in group L with T2EL.

Conclusions: Group S had high freedom from composite event rate; in group L, the rate decreased to 51% at 5 years with T2EL at discharge.

目的:我们旨在研究初始腹主动脉瘤(AAA)直径对动脉瘤囊扩张/收缩、内漏和选择性后单纯血管内动脉瘤修复(EVAR)再干预的影响。方法:对228例EVAR后监测时间>1年的患者进行分析。结果:S组5年无复合事件发生率(92.4±2.8%)显著高于L组(79.1±4.9%)。
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引用次数: 0
Lateral Dorsal Basal Lung Resection Based on Functional Preserving Sublobectomy Method: Single-Center Experience. 基于保留功能的肺叶切除术的背侧基底肺切除术:单中心经验。
Bing Han, Zheng Qin, Peirui Chen, Liqiang Yuan, Mingqiang Diao

Purpose: Functional preserving sublobectomy (FPSL), a novel balancing strategy for segmentectomy and wedge resection, allows rapid and accurate removal of invisible nodules without the use of any preoperative localization markers. This study aimed to share single-center experience of lateral dorsal basal lung resection based on FPSL, so as to provide new surgical options for thoracic surgeons.

Methods: A retrospective analysis was performed on 13 patients who underwent thoracoscopic basal lung resection after FPSL at XX hospital from January 2021 to August 2022.

Results: The operation was successfully performed in 13 patients by using FPSL, including 12 patients with malignant tumors. The mean operating time was 107.5 ± 25.6 min. The mean postoperative hospital stay was 3.7 ± 2.4 days. None of the patients needed extended excision, such as an entire basal or inferior lobectomy.

Conclusion: Our single-center experience showed that the FPSL method only dealt with the target vessels, which greatly reduced the technical difficulty of surgery. In addition, both arteries and veins could be used as target vessels, and in particular cases such as undeveloped interlobar fissure, the operation could still be completed successfully. Lateral dorsal basal lung resection based on FPSL may be a new surgical option for surgeons.

目的:保留功能的肺叶切除术(FPSL)是一种新的节段切除术和楔形切除术的平衡策略,可以在不使用任何术前定位标记的情况下快速准确地切除不可见的结节。本研究旨在分享基于FPSL的单中心背侧基底肺切除术的经验,为胸外科医生提供新的手术选择。方法:对2021年1月至2022年8月在XX医院行FPSL胸腔镜下基底肺切除术的13例患者进行回顾性分析。平均手术时间为107.5±25.6分钟。平均术后住院时间为3.7±2.4天。没有一个病人需要延长切除时间,例如整个基底叶或下叶切除术。结论:我们的单中心经验表明,FPSL方法只处理目标血管,大大降低了手术的技术难度。此外,动脉和静脉都可以作为靶血管,特别是在叶间裂不发育的情况下,手术仍然可以成功完成。基于FPSL的背侧基底肺切除术可能是外科医生的一种新的手术选择。
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引用次数: 0
Can Open Distal Repair Be Safely Used in All Patients with Type A Acute Aortic Dissection? 开放性远端修复术能安全地用于所有A型急性主动脉夹层患者吗?
Georgi Manchev, Vassil Gegouskov, Vladimir Kornovski, Georgi Yankov, Valya Goranovska, Vicktoria Ilieva, Vicktoria Petrova

Purpose: The distal suture line during aortic dissection repair can be performed by a closed technique or by an open technique. This study presents a retrospective comparison of both methods regarding their postoperative outcomes.

Patients and methods: 120 patients who underwent surgery for acute aortic dissection type A were divided into two groups. In group A (n = 81), open distal anastomosis was performed under hypothermic circulatory arrest and selective cerebral perfusion. In group B (n = 39), distal anastomosis was performed with the aorta cross-clamped under mildly hypothermic cardiopulmonary bypass. Primary outcomes were operative mortality, neurologic morbidity, and long-term survival.

Results: Hospital mortality (17.3% for the open group vs. 12.8% for the closed group, p = 0.53), permanent neurologic dysfunction (8.7% vs. 8.3%, p = 1.0), and temporary neurologic dysfunction (31.9% vs. 22.2%, p = 0.298) were not significantly different between groups. No significant difference in actuarial 5- and 10-year survival was observed (88% vs. 86% and 53 vs. 73%, respectively, p = 0.396). After propensity-score adjustment, the technique of distal aortic repair was not found to be a predictor of the primary outcomes.

Conclusion: We conclude that the open repair can be used in most if not all cases of surgical repair of type A acute aortic dissection.

目的:主动脉夹层修复过程中的远端缝合线可以通过闭合技术或开放技术进行。本研究对两种方法的术后结果进行了回顾性比较。患者和方法:将120例接受A型急性主动脉夹层手术的患者分为两组。A组(n=81)在低温停循环和选择性脑灌注下进行开放式远端吻合。B组(n=39)在轻度低温体外循环下进行远端吻合,主动脉交叉夹紧。主要结果是手术死亡率、神经系统发病率和长期生存率。结果:住院死亡率(开放组17.3%,封闭组12.8%,p=0.053)、永久性神经功能障碍(8.7%,8.3%,p=0.0)和暂时性神经功能障碍的发生率(31.9%,22.2%,p=0.0298)在各组之间没有显著差异。在5年和10年的精算生存率方面没有观察到显著差异(分别为88%对86%和53%对73%,p=0.396)。在倾向评分调整后,未发现远端主动脉修复技术是主要结果的预测因素。结论:开放式修补术可用于大多数(如果不是全部的话)A型急性主动脉夹层的外科修复。
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引用次数: 0
An Off-Pump Repair Technique for Postinfarction Apical Left Ventricular Aneurysm. 梗死后左室尖动脉瘤的非泵血修复技术。
Liangwan Chen, Zhihuang Qiu, Yunnan Hu, Yue Shen, Guanhua Fang, Heng Lu, Qingsong Wu

Purpose: The conventional surgical treatment for postinfarction left ventricular aneurysm (LVA) is open-heart repair with cardiopulmonary bypass. However, the risk of the open-heart surgery under cardiopulmonary bypass may result in an unacceptable risk for many patients with multiple comorbidities. Here, we reported a new off-pump repair technique for postinfarction apical LVA.

Methods: A new off-pump repair technique, circular banding and occlusion technique, was applied to repair the postinfarction apical LVA in 12 patients. Clinical data of all those 12 patients were retrospectively reviewed. Patients were followed up prospectively by direct interviews and echocardiographic examination.

Results: The new repair technique was successfully performed in all these 12 patients. Acute reduction of the LVA mouth diameter, the left ventricular (LV) end-diastolic volume and end-systolic volume, and an increase in the LV ejection fraction (EF) were immediately obtained after the repair. Patients had an uneventful postoperative course. They were in New York Heart Association class 1-2, and the LV volume and EF detected by echocardiography remained unchanged during an average 28.4 ± 9.9 months (range 13 to 45 months) follow-up.

Conclusions: Circular banding and occlusion is a simple, safe, and effective off-pump repair technique for postinfarction apical LVA. It can allow effective LV remodeling and improve heart function.

目的:梗死后左室动脉瘤的常规手术治疗是体外循环心内直视修复。然而,体外循环下的心内直视手术的风险可能会导致许多患有多种合并症的患者无法接受的风险。在这里,我们报道了一种新的非泵式修复技术用于梗死后根尖LVA。方法:对12例脑梗死后根尖LVA采用非泵血修复技术——圆带闭塞技术进行修复。回顾性分析12例患者的临床资料。采用直接访谈和超声心动图检查对患者进行前瞻性随访。结果:12例患者均成功完成修复。修复后,左室口径、左室舒张末容积和收缩末容积均明显降低,左室射血分数(EF)明显升高。患者术后过程平稳。纽约心脏协会分级1-2级,超声心动图检测的左室容积和左室EF在平均28.4±9.9个月(13 ~ 45个月)随访期间保持不变。结论:圆带闭塞术是一种简单、安全、有效的治疗梗死后根尖LVA的无泵修复技术。它能使左室有效重构,改善心功能。
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引用次数: 0
Aortic Annular Enlargement with Modified Y-Incision Technique Devised from Preoperative Three-Dimensional Computed Tomography. 与术前三维计算机断层扫描不同的改良Y切口主动脉瓣环扩大术。
Goki Inno, Yosuke Takahashi, Kenta Nishiya, Munehide Nagao, Takumi Kawase, Akimasa Morisaki, Toshihiko Shibata

The Y-incision technique introduced by Dr. Bo Yang in 2021 is a very innovative technique that can enlarge the aortic annulus by two or more sizes without violating the left atrium or mitral valve. However, we encountered a case in which the left coronary artery ostium was located close to the left-non commissure. Therefore, we considered it would be dangerous to expand the incision to the left coronary annulus. We therefore devised a new technique that enlarges only the noncoronary annulus in an "L" fashion instead of a "Y" fashion. In performing this surgery, preoperative three-dimensional images were useful for understanding the anatomy when planning the aortic annular enlargement procedure. The L-incision technique can be a useful alternative method of aortic annulus enlargement.

Bo博士在2021年推出的Y形切口技术是一种非常创新的技术,可以在不侵犯左心房或二尖瓣的情况下将主动脉瓣环扩大两个或两个以上的尺寸。然而,我们遇到了一个病例,其中左冠状动脉口位于左侧非连合附近。因此,我们认为将切口扩大到左冠状动脉环是危险的。因此,我们设计了一种新技术,只以“L”方式而不是“Y”方式放大非冠状环。在进行该手术时,术前三维图像有助于在计划主动脉环扩大手术时了解解剖结构。L形切口技术可能是主动脉瓣环扩大的一种有用的替代方法。
{"title":"Aortic Annular Enlargement with Modified Y-Incision Technique Devised from Preoperative Three-Dimensional Computed Tomography.","authors":"Goki Inno, Yosuke Takahashi, Kenta Nishiya, Munehide Nagao, Takumi Kawase, Akimasa Morisaki, Toshihiko Shibata","doi":"10.5761/atcs.nm.23-00153","DOIUrl":"10.5761/atcs.nm.23-00153","url":null,"abstract":"<p><p>The Y-incision technique introduced by Dr. Bo Yang in 2021 is a very innovative technique that can enlarge the aortic annulus by two or more sizes without violating the left atrium or mitral valve. However, we encountered a case in which the left coronary artery ostium was located close to the left-non commissure. Therefore, we considered it would be dangerous to expand the incision to the left coronary annulus. We therefore devised a new technique that enlarges only the noncoronary annulus in an \"L\" fashion instead of a \"Y\" fashion. In performing this surgery, preoperative three-dimensional images were useful for understanding the anatomy when planning the aortic annular enlargement procedure. The L-incision technique can be a useful alternative method of aortic annulus enlargement.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10902667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Method of Real-Time Assessment for Coronary Artery Anastomosis Skill. 一种新的冠状动脉吻合技术实时评估方法。
Kohei Abe, Hiroyuki Nishi, Kazuma Okamoto, Hitoshi Yokoyama, Hirokuni Arai, Hitoshi Yaku, Shuichiro Takanashi, Hirofumi Takemura, Tohru Asai, Young-Kwang Park

Purpose: Coronary anastomosis is the most key factor to accomplish coronary artery bypass grafting, which is one of the largest areas in cardiovascular surgery. Although we have organized on-site simulator training courses of coronary anastomosis using BEAT YOUCAN, it became difficult to continue it because of COVID-19. Therefore, we established a real-time evaluation sheet instead of an Objective Structured Assessment of Technical Skills (OSATS) evaluation sheet. The purposes of this study was to develop the real-time assessment system and to prove the correlation between the score obtained by the OSATS and the score obtained by the real-time evaluation system.

Subjects and methods: A total of 22 videos from the qualifying round of real-time coronary anastomosis competition evaluated by both the modified OSATS and the real-time evaluation system were utilized in this study. The global rating score of OSATS was compared with the global rating score of real-time evaluation system.

Results: When examined the relationship between the OSATS total score and the real-time total score, there was a significant correlation (R = 0.752, p <0.001). The OSATS general definition score and the real-time total score also showed a strong correlation (R = 0.733, p <0.001).

Conclusions: We developed a real-time assessment sheet to evaluate coronary anastomosis. This assessment sheet had a good correlation with the OSATS evaluation sheet.

目的:冠状动脉吻合是完成冠状动脉搭桥术的最关键因素,而冠状动脉搭桥是心血管外科最大的领域之一。尽管我们使用BEAT YOUCAN组织了冠状动脉吻合的现场模拟训练课程,但由于新冠肺炎,很难继续进行。因此,我们建立了一个实时评估表,而不是目标结构化技术技能评估(OSATS)评估表。本研究的目的是开发实时评估系统,并证明OSATS获得的分数与实时评估系统获得的分数之间的相关性。受试者和方法:本研究共使用了22段来自实时冠状动脉吻合比赛资格赛的视频,这些视频通过改进的OSATS和实时评估系统进行了评估。将OSATS的全球评分与实时评估系统的全球评分进行比较。结果:OSATS总分与实时总分之间存在显著相关性(R=0.752,p)。结论:我们开发了一个实时评估表来评估冠状动脉吻合,该评估表与OSATS评估表具有良好的相关性。
{"title":"A Novel Method of Real-Time Assessment for Coronary Artery Anastomosis Skill.","authors":"Kohei Abe, Hiroyuki Nishi, Kazuma Okamoto, Hitoshi Yokoyama, Hirokuni Arai, Hitoshi Yaku, Shuichiro Takanashi, Hirofumi Takemura, Tohru Asai, Young-Kwang Park","doi":"10.5761/atcs.oa.23-00089","DOIUrl":"10.5761/atcs.oa.23-00089","url":null,"abstract":"<p><strong>Purpose: </strong>Coronary anastomosis is the most key factor to accomplish coronary artery bypass grafting, which is one of the largest areas in cardiovascular surgery. Although we have organized on-site simulator training courses of coronary anastomosis using BEAT YOUCAN, it became difficult to continue it because of COVID-19. Therefore, we established a real-time evaluation sheet instead of an Objective Structured Assessment of Technical Skills (OSATS) evaluation sheet. The purposes of this study was to develop the real-time assessment system and to prove the correlation between the score obtained by the OSATS and the score obtained by the real-time evaluation system.</p><p><strong>Subjects and methods: </strong>A total of 22 videos from the qualifying round of real-time coronary anastomosis competition evaluated by both the modified OSATS and the real-time evaluation system were utilized in this study. The global rating score of OSATS was compared with the global rating score of real-time evaluation system.</p><p><strong>Results: </strong>When examined the relationship between the OSATS total score and the real-time total score, there was a significant correlation (R = 0.752, p <0.001). The OSATS general definition score and the real-time total score also showed a strong correlation (R = 0.733, p <0.001).</p><p><strong>Conclusions: </strong>We developed a real-time assessment sheet to evaluate coronary anastomosis. This assessment sheet had a good correlation with the OSATS evaluation sheet.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10902660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in Robotic Lung Lobectomy through the Anterior Approach. 机器人肺叶前路切除术的挑战。
Atsushi Osoegawa, Miyuki Abe, Michiyo Miyawaki, Takashi Karashima, Yohei Takumi, Shinkichi Takamori, Kenji Sugio

Purpose: Robot-assisted thoracic surgery (RATS) has become popular because of its minimally invasive nature and reduced burden on surgeons. The anterior approach (AA) is beneficial because it utilizes the same field of view and procedures as thoracotomy and video-assisted thoracic surgery, although the disadvantages are less well-known.

Methods: We retrospectively examined 35 consecutive patients who underwent RATS lobectomy via the AA, focusing on clinical factors and postoperative complications.

Results: The study included 12 males and 23 females with a median console time of 177 (120-346) min, median blood loss of 0 (0-100) mL, and median stapler usage of 5 (2-10) units. Postoperative complications, classified as Clavien-Dindo grade ≥III, included three cases of grade IIIa (prolonged air leakage) and one case each of grade IIIb and grade IVa (middle lobe torsion and ventricular arrhythmia). The influence of stapling device operation cannot be ruled out in prolonged air leakage and middle lobe torsion. A moderate correlation (correlation coefficient = 0.492, p = 0.003) was observed between console time and the number of staplers used.

Conclusion: Although no severe incidence of vascular injury was observed with the AA, complications related to the use of stapling devices were noted.

目的:机器人辅助胸外科手术(RATS)因其微创性和减轻外科医生负担而受到欢迎。前路入路(AA)是有益的,因为它与开胸手术和视频辅助胸外科手术使用相同的视野和程序,尽管缺点不太为人所知。方法:我们回顾性分析35例经AA行大鼠肺叶切除术的患者,重点分析临床因素和术后并发症。结果:该研究包括12名男性和23名女性,中位控制时间为177 (120-346)min,中位失血量为0 (0-100)mL,中位订书机使用量为5(2-10)个单位。术后并发症Clavien-Dindo分级≥III, IIIa级(长时间漏气)3例,IIIb级和IVa级(中肺叶扭转和室性心律失常)各1例。在长时间的漏气和中间瓣扭扭中,不能排除吻合器操作的影响。控制台时间与订书机使用次数有中等相关性(相关系数= 0.492,p = 0.003)。结论:虽然没有观察到严重的血管损伤,但注意到与吻合器使用相关的并发症。
{"title":"Challenges in Robotic Lung Lobectomy through the Anterior Approach.","authors":"Atsushi Osoegawa, Miyuki Abe, Michiyo Miyawaki, Takashi Karashima, Yohei Takumi, Shinkichi Takamori, Kenji Sugio","doi":"10.5761/atcs.oa.23-00146","DOIUrl":"10.5761/atcs.oa.23-00146","url":null,"abstract":"<p><strong>Purpose: </strong>Robot-assisted thoracic surgery (RATS) has become popular because of its minimally invasive nature and reduced burden on surgeons. The anterior approach (AA) is beneficial because it utilizes the same field of view and procedures as thoracotomy and video-assisted thoracic surgery, although the disadvantages are less well-known.</p><p><strong>Methods: </strong>We retrospectively examined 35 consecutive patients who underwent RATS lobectomy via the AA, focusing on clinical factors and postoperative complications.</p><p><strong>Results: </strong>The study included 12 males and 23 females with a median console time of 177 (120-346) min, median blood loss of 0 (0-100) mL, and median stapler usage of 5 (2-10) units. Postoperative complications, classified as Clavien-Dindo grade ≥III, included three cases of grade IIIa (prolonged air leakage) and one case each of grade IIIb and grade IVa (middle lobe torsion and ventricular arrhythmia). The influence of stapling device operation cannot be ruled out in prolonged air leakage and middle lobe torsion. A moderate correlation (correlation coefficient = 0.492, p = 0.003) was observed between console time and the number of staplers used.</p><p><strong>Conclusion: </strong>Although no severe incidence of vascular injury was observed with the AA, complications related to the use of stapling devices were noted.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10902646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Tegafur-Uracil in Resected Stage IB Lung Adenocarcinoma According to Presence or Absence of Epidermal Growth Factor Receptor Gene Mutation: A Retrospective Cohort Study. 根据表皮生长因子受体基因突变的有无对已切除的 IB 期肺癌 Tegafur-Uracil 的影响:一项回顾性队列研究。
Masaya Aoki, Ryo Miyata, Go Kamimura, Aya Harada Takeda, Takayuki Suetsugu, Keiko Mizuno, Kazuhiro Ueda

Purpose: Tegafur-uracil (UFT) is the standard postoperative adjuvant therapy for stage IB lung adenocarcinoma (LUAD) in Japan. This study aimed to determine whether UFT is effective in stage IB LUAD with and without epidermal growth factor receptor (EGFR) mutations.

Methods: This retrospective study included 169 patients with stage IB LUAD who underwent complete resection at our department between 2010 and 2021. We investigated the clinicopathological and prognostic impact of EGFR mutations as well as the postoperative use of UFT.

Results: EGFR mutation-positive cases tended to show a higher cumulative recurrence rate than EGFR mutation-negative cases (p = 0.081), while overall survival was comparable between the groups (p = 0.238). In the entire cohort, UFT administration was not an independent prognostic factor in the multivariate regression analysis (p = 0.112). According to a stratification analysis, UFT administration was independently associated with favorable overall survival (p = 0.031) in EGFR mutation-negative cases, while it was not associated with recurrence-free survival (p = 0.991) or overall survival (p = 0.398) in EGFR mutation-positive cases.

Conclusion: UFT administration can improve the prognosis of EGFR mutation-negative LUAD but not EGFR mutation-positive LUAD. Thus, clinical trials of adjuvant-targeted therapy for EGFR mutation-positive stage IB LUAD should also be conducted in Japan.

目的:替加氟-脲嘧啶(UFT)是日本治疗IB期肺腺癌(LUAD)的标准术后辅助疗法。本研究旨在确定 UFT 对表皮生长因子受体(EGFR)突变和未发生突变的 IB 期 LUAD 是否有效:这项回顾性研究纳入了 2010 年至 2021 年期间在我院接受完全切除术的 169 例 IB 期 LUAD 患者。我们研究了表皮生长因子受体(EGFR)突变对临床病理学和预后的影响,以及术后使用 UFT 的情况:表皮生长因子受体突变阳性病例的累积复发率往往高于表皮生长因子受体突变阴性病例(p = 0.081),而两组患者的总生存率相当(p = 0.238)。在整个队列中,服用 UFT 并不是多变量回归分析中的独立预后因素(p = 0.112)。根据分层分析,在表皮生长因子受体突变阴性病例中,服用UFT与良好的总生存期(p = 0.031)独立相关,而在表皮生长因子受体突变阳性病例中,服用UFT与无复发生存期(p = 0.991)或总生存期(p = 0.398)无关:结论:服用 UFT 可改善表皮生长因子受体突变阴性 LUAD 的预后,但不能改善表皮生长因子受体突变阳性 LUAD 的预后。因此,日本也应开展针对表皮生长因子受体突变阳性 IB 期 LUAD 的辅助靶向治疗临床试验。
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引用次数: 0
Scattered Media Elastic Fibers from the Aortic Root to the Ascending Aorta in a 30-Year-Old Marfan Syndrome Patient. 一名 30 岁马凡氏综合征患者主动脉根部至升主动脉的散在介质弹性纤维
Tomohiro Nakajima, Yutaka Iba, Syuichi Naraoka, Tsuyoshi Shibata, Shintaro Sugita, Nobuyoshi Kawaharada

We present a case report of a 30-year-old Marfan syndrome patient who underwent a David procedure for severe aortic valve insufficiency and Valsalva aneurysm. Harvested aortic walls were examined by pathologists. Although the tunica media of the ascending aorta contained aligned elastic fibers, the aortic root media lacked aligned elastic fibers.

我们报告了一例 30 岁马凡氏综合征患者的病例,该患者因严重主动脉瓣关闭不全和 Valsalva 动脉瘤接受了大卫手术。病理学家对采集的主动脉壁进行了检查。虽然升主动脉内膜含有排列整齐的弹性纤维,但主动脉根部内膜却缺乏排列整齐的弹性纤维。
{"title":"Scattered Media Elastic Fibers from the Aortic Root to the Ascending Aorta in a 30-Year-Old Marfan Syndrome Patient.","authors":"Tomohiro Nakajima, Yutaka Iba, Syuichi Naraoka, Tsuyoshi Shibata, Shintaro Sugita, Nobuyoshi Kawaharada","doi":"10.5761/atcs.cr.22-00044","DOIUrl":"10.5761/atcs.cr.22-00044","url":null,"abstract":"<p><p>We present a case report of a 30-year-old Marfan syndrome patient who underwent a David procedure for severe aortic valve insufficiency and Valsalva aneurysm. Harvested aortic walls were examined by pathologists. Although the tunica media of the ascending aorta contained aligned elastic fibers, the aortic root media lacked aligned elastic fibers.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10851445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86038132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
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