Biological research for nursing最新文献

Purpose: To evaluate the associations between composite dietary antioxidant index (CDAI) and common non-communicable diseases (NCDs) and explore the potential effects of inflammatory indices in these associations. Methods: We included 20,097 adults from the National Health and Nutrition Examination Survey 2003-2018. Multivariable logistic regressions were applied to evaluate the associations between CDAI and common NCDs. Mediation analysis was used to explore the role of inflammatory indices in the associations. Results: Higher CDAI was associated with a downward trend in the incidence of obesity, cardiovascular disease (CVD), chronic respiratory diseases, and chronic kidney disease (CKD) (p for trend < 0.05). The association between CDAI and CVD was influenced by C-reactive protein (CRP), red blood cell width (RDW), and neutrophil to lymphocyte ratio (NLR), with mediated proportions of 3.490%, 5.173%, and 2.351%, respectively. NLR partially contributed to the link between CDAI and CKD, with a mediating ratio of 2.746%. Additionally, we observed additive interactions between CDAI and CRP (RERI (95% CI): 0.282 (0.070, 0.494), AP (95% CI): 0.539 (0.088, 0.991), as well as RDW on CVD (RERI (95% CI): 0.318 (0.124, 0.511), AP (95% CI): 0.717 (0.217, 1.218)). There also appeared to be a weak multiplicative interaction between CDAI and RDW on CVD (p-int = 0.049). Conclusion: Our investigation ascertained that CDAI was related to common NCDs. Moreover, inflammatory indices played an important role in the associations between CDAI and NCDs.

This cross-sectional study compared plasma brain-derived neurotrophic factor (BDNF) levels among chronic primary musculoskeletal pain patients, chronic widespread pain patients, and asymptomatic controls. The study included 126 participants aged 18-65, divided into three groups of 42 each. Pain intensity was assessed using a Numeric Rating Scale (NRS), and plasma BDNF levels were measured via ELISA. Differences between groups were evaluated using ANOVA with 2000 bootstrap resamples and a bias-corrected and accelerated method. Results showed significantly higher plasma BDNF levels in chronic widespread pain patients (mean difference [MD] = 0.44; 95% CI = 0.28, 0.62; p < .001) compared to controls, and higher than in chronic primary musculoskeletal pain patients (MD = 0.83; 95% CI = 0.64, 1.02; p < .001). Chronic primary musculoskeletal pain patients had lower plasma BDNF levels compared to controls (MD = -0.39; 95% CI = -0.54, -0.24; p < .001). No significant correlations were observed between plasma BDNF levels and clinical variables. These findings suggest the potential of BDNF as a biomarker to differentiate chronic primary pain conditions.

Background: Epidural analgesia is a widely employed method in obstetric care for labor pain management. Postpartum urinary retention is a common complication that can arise during the postnatal period. This study aimed to evaluate the current status and influencing factors of postpartum urinary retention in parturients who received epidural anesthesia. Methods: We retrospectively included parturients who underwent vaginal delivery at our institution from June 2022 to October 2024. The characteristics of parturients with and without postpartum urinary retention were analyzed and compared. Logistic regression analyses were conducted to evaluate the influencing factors of postpartum urinary retention. Results: This study enrolled a cohort consisting of 520 parturients who underwent epidural anesthesia, resulting in a total of 520 instances of childbirth. Among this population, 56 parturients were identified as experiencing postpartum urinary retention. The incidence of postpartum urinary retention in parturients with epidural anesthesia was 10.77%. Correlation analysis results showed that the parity (r = 0.582), duration of analgesia (r = 0.554), degree of perineal laceration (r = 0.656) and use of oxytocin (r = 0.580) were correlated with the occurrence of postpartum urinary retention among parturients with epidural anesthesia (all p < .05). Logistic regression analysis indicated that parity (OR = 2.587, 95% CI: 1.890∼3.225), duration of analgesia (OR = 2.778, 95% CI: 2.104∼3.467), degree of perineal laceration (OR = 3.265, 95% CI: 2.620∼3.815) and use of oxytocin (OR = 2.436, 95% CI: 1.909∼3.875) were the independent influencing factors of postpartum urinary retention (all p < .05). Conclusion: It is imperative that clinical healthcare providers implement targeted preventative and management strategies to reduce postpartum urinary retention.

Objective: This study was conducted to examine the effects of massage and foot reflexology on the sleep of premature infants. Materials and Methods: The research was designed as a randomized controlled experimental study. The study population consisted of premature infants born at 30-37 weeks of gestation who were admitted to the Neonatal Intensive Care Unit of a hospital in the Central Anatolia Region. The sample included 108 premature infants divided into three groups: Massage group (n = 36), Foot reflexology group (n = 36), and Control group (n = 36). Data were collected using a neonatal follow-up form and actigraphy. Massage and foot reflexology interventions were administered to the respective groups twice daily (Morning: 07:00-09:00 and Evening: 19:00-21:00) for 15 minutes each session over two consecutive days, making up a total of four sessions. The control group received routine nursing care without any additional intervention. Pre-test (once) and post-test (once) measurements of 24-h sleep durations were assessed using actigraphy for all groups. Results: Sleep duration in the massage group increased compared to pre-intervention (251 minutes) and the control group (272 minutes), while the sleep duration in the foot reflexology group similarly increased compared to pre-intervention (268 minutes) and the control group (266 minutes) (p < .001). Sleep efficiency also showed a significant increase post-intervention, rising to 73% in the massage group and 71.8% in the foot reflexology group compared to the control group (p < .001). Furthermore, the number of awakenings and wakefulness duration significantly decreased in the massage and foot reflexology groups compared to the control group (p < .05). Conclusion: The findings indicate that massage and foot reflexology are effective non-pharmacological methods for improving sleep duration and sleep efficiency while reducing wakefulness duration and the number of awakenings in premature infants.

Maternal mental health conditions significantly contribute to pregnancy-related mortality in the United States. Approximately 20-25% of postnatal women exhibit symptoms of depressive and anxiety disorders. Mental health is influenced by stress, which affects mood, cognition, and behavior. Heart rate variability (HRV), the time interval between consecutive heartbeats, is a physiological marker for assessing stress levels, providing critical insights into the body's autonomic responses. Wearable devices measuring HRV offer a non-invasive method to monitor stress and mental health, enabling early detection of maternal stress dynamics to facilitate timely interventions. In this scoping review, we aimed to capture the current state of science on two areas of focus: (1) utilization of wearable technology for HRV monitoring in pregnant and postpartum women, (2) findings from these perinatal HRV studies, including observed HRV trends throughout pregnancy and postpartum, as well as the association between HRV, perinatal stress, and mental health. The six included perinatal HRV studies employed five fitness tracking wearables, utilizing either periodic or continuous 24-h monitoring. Findings include evidence that HRV declines during pregnancy, with a return to normal levels postpartum. Associations between HRV and stress were inconsistent across studies, with some demonstrating correlations and others reporting no relationship. Postpartum HRV measurements effectively differentiated between women with postpartum depression (PPD) versus those with adjustment disorder (AJD), demonstrating high diagnostic accuracy. In this scoping review, HRV shows promise as a stress biomarker among pregnant/postpartum people, although more work is needed to standardize optimal methods of wearable HRV measurement in this population.

Background: Overweight and obesity are associated with adverse psychological outcomes, compromised body composition, and reduced quality of life (QoL). While exercise training has been proposed as an effective intervention, its impact on these outcomes remains unclear. Objective: This systematic review and meta-analysis evaluated the effects of exercise training on psychological outcomes, body composition, and QoL in overweight or obese adults. Methods: A systematic review and meta-analysis were performed through July 2024, utilizing multiple databases. Random-effects models were used to calculate standardized mean differences (SMDs) or mean differences (MDs), with corresponding 95% confidence intervals (CIs). Results: Thirty-one trials involving 2779 participants were included. Exercise training significantly improved mental health (SMD: 0.25, 95% CI: 0.11, 0.39, p = .0003), depression (SMD: -0.52, 95% CI: -0.86, -0.18, p = .003), mood (SMD: 7.55, 95% CI: 10.78, 4.31, p < .00001), waist circumference (MD: -2.77 cm, 95% CI: -4.60, -0.94, p = .003), and lean body mass (MD: 1.16 kg, 95% CI: 0.62, 1.69, p < .0001). Improvements were also observed in various QoL domains, including social functioning (p = .004), physical functioning (p < .00001), vitality (p = .003), general health (p = .001), and environmental quality (p < .00001). However, some psychological, body composition, and QoL variables did not show significant effects. Conclusion: Exercise training positively impacts psychological outcomes, body composition, and multiple QoL domains in overweight and obese adults. These findings highlight the importance of exercise in lifestyle interventions. Further research is needed to determine long-term and consistent effects.

Background: Inflammation has been linked to an increased risk of depression, but there is limited and conflicting research on the role of inflammatory markers in adolescent depression. The purpose of this study was to examine associations between cytokines TNF-α, IL-1β, IL-6, and IL-8 and depression among a community-based sample of adolescents (13-19 years of age). Methods: Salivary samples were self-collected by adolescents for assay of cytokines. The Patient Health Questionnaire-9 (PHQ-9) was used to measure depressive symptoms and clinical depression, where a score ≥11 indicated the threshold for experiencing clinical depression. Multiple linear and logistic regression models were used to examine the relationships between cytokines and depression, adjusting for age, sex, ethnicity, income, and body mass index. Results: The mean age of the 83 participants was 15.86 years. Eight participants screened positive for depression; the mean depressive symptom score was 5.11. Higher levels of IL-6 (Coef = 1.33, p < .001) and IL-8 (Coef = 0.69, p = .025) were associated with more frequent depressive symptoms while higher levels of TNF-α (OR = 2.50, p = .002), IL-1β (OR = 1.98, p = .001), and IL-8 (OR = 2.44, p = .008) were associated with greater odds of meeting criteria for clinical depression. Conclusions: Future research should focus on factors that induce higher cytokine levels and the mechanisms underlying their effects on depression. Cytokines assessed in this study may ultimately have implications as methods for depression screening or targets for biologic interventions to prevent and treat adolescent depression.

Purpose: Obese women with breast cancer experience high symptom burden, poor quality of life, and increased mortality compared to non-obese women with breast cancer. Obesity-related changes to the bacteria of the gut, the GI microbiome, may be one such mechanism for these differences in outcomes. The purpose of this work is to report symptom burden and GI microbiome composition between obese and non-obese women with breast cancer to identify potential microbial influences for symptom severity. Methods: 59 women with breast cancer (26 obese, 33 non-obese) provided symptom reports using the Memorial Symptom Assessment Scale and stool samples for 16S analysis one week after receiving chemotherapy. Symptom reports were summarized and examined for differences based on obesity. Fecal microbiome analysis was compared between groups using alpha-diversity (Shannon index), beta-diversity (Principal Coordinate Analysis with weighted UniFrac distances), and LASSO analysis of abundance of bacterial species. Results: While symptom burden was high, it did not differ based on obesity status. Alpha- and beta-diversity did not find significant differences based on obesity, but LASSO analysis identified eight bacteria to be significantly enriched in obese participants: Collinsella aerofacien, Prevotella 7, Coprobacillus cateniformis, Ruminococcus torques group, Agathobacter, Frisingicoccus, Roseburia inulinivorans, and Monoglobus pectinilyticus. Conclusions: Identifying biologic mechanisms driving symptoms is necessary for the development of therapies to reduce cancer-related symptom burden. While obesity may alter the GI microbiome and influence symptom burden in women with breast cancer, these effects may be outweighed by the effects of chemotherapy on the gut.

Background: In the clinical setting, individuals with neurogenic bladder dysfunction commonly utilize indwelling urinary catheters for urinary management. The comparative efficacy of catheter clamping versus continuous free drainage in this patient population is yet to be established. This meta-analysis aims to explore the efficacy and safety of catheter clamping versus natural drainage in patients with neurogenic bladder, to provide evidence to support the treatment and nursing care of these patients. Methods: Two researchers conducted a literature search in Clinicaltrials et al. databases for Randomized Controlled Trials (RCTs) comparing clamping of the catheter to free drainage in patients with neurogenic bladder who have indwelling urinary catheters. The RCT bias risk assessment tool recommended by the Cochrane Handbook was used for quality assessment. RevMan 5.3 software were used for meta-analysis. Results: A total of 8 RCTs involving 772 patients with neurogenic bladder were enrolled. Catheter clamping significantly increased the volume of first urination in patients [MD = 52.86, 95%CI (42.30, 63.41), p < .001]. The difference in time to first urination [SMD = 0.10, 95%CI (-0.68, 0.89), p = .80], residual urine volume [MD = -5.18, 95%CI (-17.27, 6.90), p = .40], incidence of urinary retention [MD = 1.07, 95%CI (0.30, 3.87), p = .92], the incidence of urinary tract infection [RR = 1.38, 95%CI (0.64, 2.97), p = .42] between the catheter clamping group and the natural drainage group were not statistically significant. The results of Egger's regression analysis indicated no evidence of statistical publication bias. Conclusion: In light of the existing body of evidence, the routine practice of catheter clamping in catheterized patients with neurogenic bladder is not recommended.