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Impact of sarcopenic obesity on surgical complications and oncologic outcomes of upper gastrointestinal tumors: A systematic review and meta-analysis. 肌肉松弛性肥胖对上消化道肿瘤手术并发症和肿瘤治疗效果的影响:系统回顾和荟萃分析。
Pub Date : 2024-09-27 DOI: 10.1016/j.cireng.2024.09.005
Luz Divina Juez, Ana Del Carmen Ortega, Pablo Priego, Juan Carlos García Pérez, José María Fernández-Cebrián, Jose I Botella-Carretero

Sarcopenic obesity (SO) is a new entity whose definition encompasses the diagnosis of overweight in malnourished patients. The aim of the review was to assess the impact of body composition in patients with esophago-gastric tumors (EGT) on perioperative and oncological outcomes. This systematic review was conducted under the PRISMA guidelines. MEDLINE (PubMed), Embase, Web of Science and SCOPUS databases were searched until January 2024. Sixteen articles were identified for analysis analyzing 5,378 patients. The prevalence of SO was 10% (95%CI: 6-16; I2 = 94%). Preoperative diagnosis of SO was associated with a twofold increased risk of severe postoperative complications (OR 2.32 [95%CI 1.41-3.82] I2 = 70%). Meta-analysis of overall survival outcomes identified that SO was associated with worse overall survival (HR 2.30; 95%CI 1.46-3.61).

肌营养不良性肥胖(Sarcopenic obesity,SO)是一种新的疾病,其定义包括营养不良患者的超重诊断。本综述旨在评估食管胃肿瘤(EGT)患者的身体成分对围手术期和肿瘤治疗效果的影响。本系统性综述根据 PRISMA 指南进行。检索了MEDLINE(PubMed)、Embase、Web of Science和SCOPUS数据库,检索期至2024年1月。最终确定了 16 篇文章,对 5378 名患者进行了分析。SO的患病率为10%(95%CI:6-16;I2 = 94%)。术前诊断出 SO 与严重术后并发症风险增加两倍有关(OR 2.32 [95%CI 1.41-3.82] I2 = 70%)。总体生存结果的 Meta 分析表明,SO 与总体生存率降低有关(HR 2.30;95%CI 1.46-3.61)。
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引用次数: 0
Robotic Approach for Remnant Cholelithiasis and CBD Exploration for Gallstones Removal. 机器人方法治疗残余胆石症,CBD探查术取出胆结石。
Pub Date : 2024-09-27 DOI: 10.1016/j.cireng.2024.08.004
Aram Rojas, Pierce Paterakos, Sarah B Hays, Melissa E Hogg
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引用次数: 0
Indocyanine green in laparoscopic cholecystectomy: utility and correlation with a preoperative risk score. 腹腔镜胆囊切除术中的吲哚菁绿:实用性以及与术前风险评分的相关性。
Pub Date : 2024-09-19 DOI: 10.1016/j.cireng.2024.09.004
Maria Luisa Galaviz-Sosa, Eric Herrero Fonollosa, María Isabel García-Domingo, Judith Camps Lasa, María Galofré Recasens, Melissa Arias Aviles, Esteban Cugat Andorrà

Background: This study aims to compare the visualization of the cystic duct-common bile duct junction with indocyanine green (ICG) among 3 groups of patients divided according to the difficulty of elective laparoscopic cholecystectomy.

Methods: Conducted at a single center, this non-randomized, prospective, observational study encompassed 168 patients who underwent elective laparoscopic cholecystectomy and were assessed with a preoperative risk score to predict difficult cholecystectomies, including clinical factors and radiological findings. Three groups were identified: low, moderate, and high risk. A dose of 0.25 mg of IV ICG was administered during anesthesia induction and the different objectives were evaluated.

Results: The visualization of the cystic duct-common bile duct junction was achieved in 28 (100%), 113 (91.1%), and 10 (63%) patients in the low, moderate, and high-risk groups, respectively. The high-risk group had longer total operative time, higher conversion, more complications and longer hospital stay. In the surgeon's subjective assessment, ICG was considered useful in 36% of the low-risk group, 58% in the moderate-risk group, and 69% in the high-risk group. Additionally, there were no cases where ICG modified the surgeon's surgical approach in the low-risk group, compared to 11% in the moderate-risk group and 25% in the high-risk group (p < 0.01).

Conclusions: The results of this study confirm that in the case of difficult cholecystectomies, the visualization of the cystic duct-common bile duct junction is achieved in 63% of cases and prompts a modification of the surgical procedure in one out of four patients.

研究背景本研究旨在比较根据择期腹腔镜胆囊切除术难度划分的三组患者使用吲哚菁绿(ICG)观察胆囊管-胆总管交界处的情况:这项非随机、前瞻性、观察性研究在单个中心进行,涵盖了 168 名接受择期腹腔镜胆囊切除术的患者,并通过术前风险评分进行评估,以预测胆囊切除术的难度,包括临床因素和放射学检查结果。结果分为三组:低风险组、中度风险组和高度风险组。在麻醉诱导过程中静脉注射0.25毫克ICG,并对不同目标进行评估:结果:低、中、高风险组分别有 28 例(100%)、113 例(91.1%)和 10 例(63%)患者实现了胆囊管-胆总管交界处的可视化。高风险组的总手术时间更长,转化率更高,并发症更多,住院时间更长。根据外科医生的主观评估,低风险组中有 36% 的患者认为 ICG 有用,中度风险组中有 58% 的患者认为 ICG 有用,高风险组中有 69% 的患者认为 ICG 有用。此外,ICG 在低风险组中没有改变外科医生手术方法的病例,而在中度风险组和高风险组中分别为 11% 和 25%(P 结论:ICG 在低风险组和中度风险组中都是有用的:本研究结果证实,在疑难胆囊切除术中,63% 的病例能看到胆囊管-胆总管交界处,每四名患者中就有一人需要修改手术方法。
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引用次数: 0
Need for a targeted perioperative antibiotic treatment protocol for patients with preoperative biliary drainage undergoing pancreaticoduodenectomy. 需要为接受胰十二指肠切除术的术前胆道引流患者制定有针对性的围手术期抗生素治疗方案。
Pub Date : 2024-09-19 DOI: 10.1016/j.cireng.2024.09.003
Judith Camps-Lasa, María Isabel García-Domingo, Eric Herrero Fonollosa, María Luisa Galaviz Sosa, María Galofré Recasens, Aurora Rodríguez Campos, Xavier Serra-Aracil, Esteban Cugat Andorrá

Purpose: To evaluate the bacterobilia in patients undergoing pancreaticoduodenectomy (PD) based on whether they carry a preoperative biliary drainage or not and to analyse if a targeted perioperative antibiotic treatment based on the expected microbiology leads in no differences in Surgical Site Infections (SSI) between the groups.

Methods: Retrospective observational single-center study of patients undergoing pancreaticoduodenectomy with preoperative biliary stent (group P, Prosthesis) and without stent (group NP, No Prosthesis). Postoperative complications including SSI and its subtypes were analyzed after applying a targeted perioperative antibiotic treatment protocol with cefotaxime and metronidazole (group NP) and piperacillin-tazobactam (group P).

Results: Between January 2014 and December 2021, 127 patients were treated (84 in group NP and 43 in group P). Intraoperative cultures were positive in 16.7% (group NP) vs 76.7% (group P, p < 0.01). Microorganisms isolated in group NP included Enterobacterales (10.7%) and Enterococcus spp. (7.1%) with no Candida detected. In group P: Enterobacterales (51.2%), Enterococcus spp. (48.8%), and Candida (16.3%) were higher (p < 0.01%). No differences in morbidity and mortality were observed between the groups. SSI rate was 17.8% in group NP and 23.2% in group P (ns).

Conclusion: Bacterobilia differs in patients with biliary drainage, showing a higher presence of Enterobacterales, Enterococcus spp., and Candida. There were no differences in SSI incidence after applying perioperative antibiotic treatment tailored to the expected microorganisms in each group. This raises the need to reconsider conventional surgical prophylaxis in patients with biliary stent.

目的:根据接受胰十二指肠切除术(PD)的患者是否在术前进行胆道引流,评估患者的细菌嗜好,并分析根据预期的微生物学情况进行有针对性的围手术期抗生素治疗是否会导致两组患者的手术部位感染(SSI)无差异:单中心回顾性观察研究:对接受胰十二指肠切除术的患者进行术前胆道支架(P组,支架)和无支架(NP组,无支架)手术。在采用头孢他啶和甲硝唑(NP组)和哌拉西林-他唑巴坦(P组)的围手术期针对性抗生素治疗方案后,对包括SSI及其亚型在内的术后并发症进行了分析:2014年1月至2021年12月,127名患者接受了治疗(NP组84人,P组43人)。16.7%(NP 组)与 76.7%(P 组)的术中培养结果呈阳性,P 组为阴性:胆道引流患者的细菌嗜好不同,肠杆菌、肠球菌属和念珠菌的嗜好更高。针对各组预期微生物采用围手术期抗生素治疗后,SSI 发生率并无差异。因此,有必要重新考虑胆道支架患者的常规手术预防措施。
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引用次数: 0
Embolize, supercharge, resect: Embolization to enhance hepatic vascularization prior to en-bloc pancreas and arterial resection. 栓塞、增压、切除: 在胰腺全层和动脉切除术之前,通过栓塞增强肝脏血管。
Pub Date : 2024-09-18 DOI: 10.1016/j.cireng.2024.08.001
Juli Busquets, Luis Secanella, Thiago Carnaval, Maria Sorribas, Mónica Serrano-Navidad, Esther Alba, Elena Escalante, Sandra Ruiz-Osuna, Núria Peláez, Juan Fabregat

Introduction: Embolization could increase the resectability of pancreatic tumors by supercharging visceral arterial perfusion prior to pancreatic surgery with arterial en-bloc resection. Its indications, however, are controversial.

Methods: We retrospectively analyzed the results of a single-center database of patients undergoing pancreatic surgery with arterial resection (AR) after preoperative arterial embolization (PAE) to increase hepatic vascular flow and spare arterial reconstruction.

Results: PAE was planned in 15 patients with arterial involvement due to pancreatic tumors. Three patients were excluded due to the finding of irresectable disease during surgery. Twelve cases were resected because of pancreatic cancer (10), distal cholangiocarcinoma (1), and pancreatic neuroendocrine tumor (1). Arterial involvement in these cases required embolization of the substitute right hepatic artery (RHA) (5), left hepatic artery (1), and common hepatic artery (CHA) (6) to enhance liver vascularization. Two patients presented migration of the vascular plug after PAE. Six pancreatoduodenectomies and 6 distal pancreatectomies were performed, the latter associated with en-bloc celiac trunk and CHA resection. R0 was achieved in 7 out of 12 patients, and pathological vascular involvement was confirmed in 8. Postoperative complications included one patient who developed gastric ischemia and underwent gastrectomy, and one patient who underwent reoperation for acute cholecystitis with liver abscesses.

Conclusion: Preoperative arterial embolization before pancreatic surgery with hepatic arterial resection enables surgeons to precondition hepatic vascularization and prevent hepatic ischemia. In addition, this avoids having to perform arterial anastomosis in the presence of pancreatic suture.

导言:栓塞术可在胰腺手术前通过动脉全切增加内脏动脉灌注,从而提高胰腺肿瘤的可切除性。然而,其适应症还存在争议:我们回顾性分析了单中心数据库中接受动脉切除术(AR)的胰腺手术患者术前动脉栓塞(PAE)以增加肝脏血管流量和备用动脉重建的结果:15例因胰腺肿瘤导致动脉受累的患者计划进行PAE。结果:15 例因胰腺肿瘤导致动脉受累的患者计划进行 PAE,其中 3 例患者因手术中发现无法切除的疾病而被排除。12例患者因胰腺癌(10例)、远端胆管癌(1例)和胰腺神经内分泌肿瘤(1例)而被切除。这些病例的动脉受累需要栓塞替代的右肝动脉(RHA)(5 例)、左肝动脉(1 例)和肝总动脉(CHA)(6 例),以增强肝脏血管。两名患者在 PAE 术后出现血管栓塞移位。共进行了6例胰十二指肠切除术和6例远端胰腺切除术,后者与腹腔干和CHA全切术相关。12例患者中有7例实现了R0,8例患者的病理血管受累得到证实。术后并发症包括一名患者出现胃缺血而接受胃切除术,一名患者因急性胆囊炎合并肝脓肿而再次手术:结论:在进行胰腺手术和肝动脉切除术之前进行术前动脉栓塞,可使外科医生对肝脏血管进行预处理,防止肝脏缺血。此外,这还避免了在胰腺缝合时进行动脉吻合。
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引用次数: 0
Diathermy Versus Scalpel in Midline Abdominal Incision: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 腹部中线切开术中的热疗与手术刀:随机对照试验的系统回顾和元分析》。
Pub Date : 2024-09-18 DOI: 10.1016/j.cireng.2024.09.002
Nicole Dos Santos Pimenta, Ana Clara Felix de Farias Santos, João Pedro Costa Esteves Almuinha Salles, Juliana Millani de Oliveira, Pedro Henrique Costa Matos da Silva, Renan Carlo Colombari

Introduction: Our study aimed to compare the midline abdominal incision with scalpel and diathermy.

Methods: PubMed, EMBASE, and Cochrane were searched through January 2024 following PRISMA guidelines (PROSPERO, ID: CRD42024516771), and only randomized controlled trials were included. Heterogeneity was assessed using Cochran's Q test and the I2 heterogeneity index. Statistical analysis was performed using Review Manager 5.4 software.

Results: Six randomized controlled trials were included, from which 469 patients (51.5%) received diathermy incision and 442 patients (48.5%) underwent the scalpel technique. Patients treated with the electrocautery approach had less incision blood loss (MD -17.57 mL; P < .01). No statistically significant differences were found between groups regarding wound infection incidence, incision time, incision area or first-day postoperative pain.

Conclusion: Diathermy use in midline abdominal incision may be advocated as it demonstrated a significant reduction in incision-related blood loss, with no differences in wound infection or early postoperative pain incidences compared to the scalpel.

简介我们的研究旨在比较腹部中线切口与手术刀和电热疗法:按照 PRISMA 指南(PROSPERO,ID:CRD42024516771)检索了 PubMed、EMBASE 和 Cochrane,检索期至 2024 年 1 月,仅纳入了随机对照试验。异质性采用 Cochran's Q 检验和 I2 异质性指数进行评估。使用Review Manager 5.4软件进行统计分析:共纳入了 6 项随机对照试验,其中 469 名患者(51.5%)接受了电热切口术,442 名患者(48.5%)接受了手术刀技术。采用电灼法治疗的患者切口失血量较少(MD -17.57 mL; P 结论:电灼法在中线腹腔镜手术中的应用可减少切口失血量:腹部中线切开术中使用电热疗法可显著减少切口相关失血量,与手术刀相比,伤口感染或术后早期疼痛发生率没有差异,因此值得提倡。
{"title":"Diathermy Versus Scalpel in Midline Abdominal Incision: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Nicole Dos Santos Pimenta, Ana Clara Felix de Farias Santos, João Pedro Costa Esteves Almuinha Salles, Juliana Millani de Oliveira, Pedro Henrique Costa Matos da Silva, Renan Carlo Colombari","doi":"10.1016/j.cireng.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.cireng.2024.09.002","url":null,"abstract":"<p><strong>Introduction: </strong>Our study aimed to compare the midline abdominal incision with scalpel and diathermy.</p><p><strong>Methods: </strong>PubMed, EMBASE, and Cochrane were searched through January 2024 following PRISMA guidelines (PROSPERO, ID: CRD42024516771), and only randomized controlled trials were included. Heterogeneity was assessed using Cochran's Q test and the I<sup>2</sup> heterogeneity index. Statistical analysis was performed using Review Manager 5.4 software.</p><p><strong>Results: </strong>Six randomized controlled trials were included, from which 469 patients (51.5%) received diathermy incision and 442 patients (48.5%) underwent the scalpel technique. Patients treated with the electrocautery approach had less incision blood loss (MD -17.57 mL; P < .01). No statistically significant differences were found between groups regarding wound infection incidence, incision time, incision area or first-day postoperative pain.</p><p><strong>Conclusion: </strong>Diathermy use in midline abdominal incision may be advocated as it demonstrated a significant reduction in incision-related blood loss, with no differences in wound infection or early postoperative pain incidences compared to the scalpel.</p>","PeriodicalId":93935,"journal":{"name":"Cirugia espanola","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the efficacy and concordance of indocianine color green angiography in oncoplastic and reconstructive breast surgery. Preliminary results of the gBREAST-22 prospective study. 评估吲哚倩宁色绿血管造影在乳房肿瘤整形和再造手术中的疗效和一致性。gBREAST-22前瞻性研究的初步结果。
Pub Date : 2024-09-18 DOI: 10.1016/j.cireng.2024.08.002
Benigno Acea-Nebril, Alejandra García-Novoa, Sergio Rodríguez-Rojo, Carlota Díaz-Carballada, Alberto Bouzón-Alejandro

Introduction: During oncoplastic procedures, the vascularization and perfusion of the skin flaps is modified, thus increasing the possibility of skin necrosis. The objective of this study is to evaluate the effectiveness of indocyanine color green angiography (ICG-A) to determine intraoperative skin necrosis after oncoplastic surgery or skin-sparing or nipple-skin sparing mastectomy (NSSM).

Patients and method: Prospective observational study to evaluate the sensitivity, specificity and positive and negative predictive values ​​of the ICG-A in women with high-risk breast cancer.

Results: 98 women and 156 breasts were included in the study. A total of 20 women (20.4%) presented an image of ischemia in the ICG-A. 21 women (21.4%) presented ischemic events in the postoperative period, 71.4% of these events had been detected in the third ICG-A. Three of these patients (3.1%) presented a serious complication that required reintervention. The sensitivity and specificity of the ICG-A was 71.4% and 93.5%, respectively.

Conclusions: ICG-A has high specificity and negative predictive value for detecting areas of low perfusion. In breast units with highly complex surgery, it can be useful to plan extreme surgeries and identify skin areas of low perfusion.

介绍:在肿瘤整形手术中,皮瓣的血管和灌注会发生改变,从而增加皮肤坏死的可能性。本研究旨在评估吲哚菁绿血管造影术(ICG-A)对确定肿瘤整形手术或保皮或乳头保皮乳房切除术(NSSM)术中皮肤坏死的有效性:前瞻性观察研究,评估 ICG-A 在高危乳腺癌女性患者中的敏感性、特异性以及阳性和阴性预测值:研究共纳入 98 名女性和 156 个乳房。共有 20 名妇女(20.4%)在 ICG-A 中显示出缺血图像。21名妇女(21.4%)在术后出现缺血症状,其中71.4%的缺血症状是在第三次ICG-A检查中发现的。其中有三名患者(3.1%)出现了严重的并发症,需要重新进行干预。A-VIC的敏感性和特异性分别为71.4%和93.5%:ICG-A在检测低灌注区域方面具有很高的特异性和阴性预测价值。在进行高度复杂手术的乳腺科室,ICG-A 可用于计划极端手术和识别皮肤低灌注区域。
{"title":"Evaluation of the efficacy and concordance of indocianine color green angiography in oncoplastic and reconstructive breast surgery. Preliminary results of the gBREAST-22 prospective study.","authors":"Benigno Acea-Nebril, Alejandra García-Novoa, Sergio Rodríguez-Rojo, Carlota Díaz-Carballada, Alberto Bouzón-Alejandro","doi":"10.1016/j.cireng.2024.08.002","DOIUrl":"10.1016/j.cireng.2024.08.002","url":null,"abstract":"<p><strong>Introduction: </strong>During oncoplastic procedures, the vascularization and perfusion of the skin flaps is modified, thus increasing the possibility of skin necrosis. The objective of this study is to evaluate the effectiveness of indocyanine color green angiography (ICG-A) to determine intraoperative skin necrosis after oncoplastic surgery or skin-sparing or nipple-skin sparing mastectomy (NSSM).</p><p><strong>Patients and method: </strong>Prospective observational study to evaluate the sensitivity, specificity and positive and negative predictive values ​​of the ICG-A in women with high-risk breast cancer.</p><p><strong>Results: </strong>98 women and 156 breasts were included in the study. A total of 20 women (20.4%) presented an image of ischemia in the ICG-A. 21 women (21.4%) presented ischemic events in the postoperative period, 71.4% of these events had been detected in the third ICG-A. Three of these patients (3.1%) presented a serious complication that required reintervention. The sensitivity and specificity of the ICG-A was 71.4% and 93.5%, respectively.</p><p><strong>Conclusions: </strong>ICG-A has high specificity and negative predictive value for detecting areas of low perfusion. In breast units with highly complex surgery, it can be useful to plan extreme surgeries and identify skin areas of low perfusion.</p>","PeriodicalId":93935,"journal":{"name":"Cirugia espanola","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemoglobinuria following reabsorbed hemoperitoneum. 重吸收性腹腔积血后出现血红蛋白尿。
Pub Date : 2024-09-18 DOI: 10.1016/j.cireng.2024.08.003
Owen Korn, Álvaro Morales, Sebastián Sapiain, María Jesús Vial
{"title":"Hemoglobinuria following reabsorbed hemoperitoneum.","authors":"Owen Korn, Álvaro Morales, Sebastián Sapiain, María Jesús Vial","doi":"10.1016/j.cireng.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.cireng.2024.08.003","url":null,"abstract":"","PeriodicalId":93935,"journal":{"name":"Cirugia espanola","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncommon anatomical variation of the origin of the right upper pulmonary vein detected by 3D reconstruction prior to robotic segmentectomy. 机器人分段切除术前通过三维重建发现的右上肺静脉起源的罕见解剖变异。
Pub Date : 2024-09-04 DOI: 10.1016/j.cireng.2024.07.009
Francisco J Gómez Valle, Cristina Rivas Duarte, Oscar Colmenares Mendoza, María Teresa Gómez Hernández
{"title":"Uncommon anatomical variation of the origin of the right upper pulmonary vein detected by 3D reconstruction prior to robotic segmentectomy.","authors":"Francisco J Gómez Valle, Cristina Rivas Duarte, Oscar Colmenares Mendoza, María Teresa Gómez Hernández","doi":"10.1016/j.cireng.2024.07.009","DOIUrl":"10.1016/j.cireng.2024.07.009","url":null,"abstract":"","PeriodicalId":93935,"journal":{"name":"Cirugia espanola","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Male breast cancer: A multicenter study in Aragon over 27 years. 男性乳腺癌:阿拉贡 27 年来的一项多中心研究。
Pub Date : 2024-09-04 DOI: 10.1016/j.cireng.2024.09.001
Olga Dobato Portoles, Daniel Aparicio Lopez, Reyes Ibañez Carreras, Elena Aguirre Ortega, Beatriz Eizaguirre Zarza, Carmen García Mur, Aurora Carrasquer Puyal, María Pilar Cebollero Benito, Laura Isabel Comín Novella, Marta Allue Cabañuz, Fernando Martinez Ubieto, Ramón Sousa Domínguez, Javier Torcal Aznar, Carmen Casamayor Franco

Introduction: Male breast cancer accounts for 1% of all breast cancers. Its low frequency leads to a lack of awareness, resulting in significant diagnostic delays. Additionally, this limits the available evidence, which primarily uses diagnostic-therapeutic algorithms based on women.

Objectives: To analyze the prevalence, clinical presentation, anatomical and pathological characteristics, and prognosis of male breast cancer using one of the largest series available. Secondarily, to compare our data with studies conducted in women.

Materials and methods: A multicenter, observational, descriptive, retrospective study was conducted in the autonomous community of Aragon, Spain, from 1995 to 2022 including men with a pathological diagnosis of breast cancer.

Results: A total of 148 patients were included, with a prevalence of 1%. The most common clinical presentation was a palpable retroareolar mass. Invasive ductal carcinoma was the most frequent type (88.89%), and luminal B was the predominant subtype (47.76%). Surgery was the most utilized treatment; mastectomy was performed in 90.34% and AL in 46.89%. At diagnosis, 52.46% had extramammary involvement. The recurrence rate was 24.1%, and the mortality attributed to the disease was 14.6%.

Conclusions: There is a high rate of metastatic involvement at diagnosis, a high percentage of mutilating surgeries, and a high number of recurrences compared to available studies on males. Additionally, a worse prognosis is observed compared to breast cancer in women, despite these tumors having a less aggressive molecular subtype. These findings highlight the importance of conducting studies focused on men to develop specific protocols.

导言男性乳腺癌占所有乳腺癌的 1%。由于发病率低,人们对其缺乏认识,导致诊断严重延误。此外,这也限制了现有的证据,因为现有证据主要使用基于女性的诊断治疗算法:目的:利用现有最大规模的系列研究之一,分析男性乳腺癌的发病率、临床表现、解剖和病理特征以及预后。其次,将我们的数据与针对女性的研究进行比较:从 1995 年到 2022 年,我们在西班牙阿拉贡自治区开展了一项多中心、观察性、描述性和回顾性研究,研究对象包括病理诊断为乳腺癌的男性患者:共纳入 148 名患者,发病率为 1%。最常见的临床表现是可扪及乳晕后肿块。浸润性导管癌是最常见的类型(88.89%),管腔 B 是最主要的亚型(47.76%)。手术是最常用的治疗方法;90.34%的患者接受了乳房切除术,46.89%的患者接受了AL术。确诊时,52.46%的患者有乳腺外受累。复发率为 24.1%,死亡率为 14.6%:结论:与现有的男性研究相比,乳腺癌的诊断转移率高,切除手术比例高,复发率高。此外,与女性乳腺癌相比,尽管这些肿瘤的分子亚型侵袭性较低,但预后较差。这些发现凸显了开展以男性为重点的研究以制定特定方案的重要性。
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引用次数: 0
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Cirugia espanola
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