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Non-inferiority clinical trial. Features and practical considerations 非劣效性临床试验。特点和实际考虑因素。
Pub Date : 2025-01-01 DOI: 10.1016/j.cireng.2024.07.008
Xavier Serra-Aracil , Marc Fradera
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引用次数: 0
Wandering spleen as a cause of acute abdomen 游走脾是急腹症的病因之一。
Pub Date : 2025-01-01 DOI: 10.1016/j.cireng.2024.05.019
María Abellán López , Luis Carrasco González , Benito Manuel Flores Pastor , Victoriano Soria Aledo
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引用次数: 0
Decision making: How do I make good decisions? 决策:我如何做出好的决策?
Pub Date : 2024-12-20 DOI: 10.1016/j.cireng.2024.12.006
Rocío Franco Herrera, María Dolores Pérez Díaz
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引用次数: 0
Radioguided parathyroidectomy: How does it contribute to surgery? 放射引导甲状旁腺切除术:对手术有何帮助?
Pub Date : 2024-12-20 DOI: 10.1016/j.cireng.2024.12.005
Pilar Salvador Egea, Isabel Blanco Saiz, Emma Anda Apiñániz, Aitor Redondo Expósito, Cristina Erce García, Irati Pérez Otermin, Naomi Cruz Vásquez

Objective: To evaluate whether a radioguided approach allows a higher intraoperative detection rate of adenoma and a minimally invasive parathyroidectomy (MIP), with the same or better cure rate of hyperparathyroidism secondary to parathyroid adenoma.

Methods: This was an observational, prospective, single-center study involving 254 consecutive patients with primary hyperparathyroidism, between 2017 and 2022. A total of 258 procedures were performed: 129 non radioguided (NRS) and 129 radioguided (RS) (112 with intravenous 99mTc- MIBI and 17 with ultrasound-guided intralesional 99mTc-MAA injection) with an intraoperative gamma probe and gamma camera. Follow-up was performed for at least one year.

Results: There were no differences between the groups in terms of age, sex, preoperative calcium or parathyroid hormone levels, adenoma localization with 99mTc-MIBI-gammagraphy and ultrasound, and surgical morbidity. Intraoperative surgical localization was 97.7% in both groups. Statistically significant differences supported RS: It allowed to perform MIP (RS: 96.9%, NRS 88.4%; p = 0.015), also in patients with previous neck surgery (RS: 75%, NRS: 28%; p = 0.019) and with ectopic adenomas (RS: 93.3%, NRS: 71.4%; p = 0.012). The operative time was significantly shorter (RS: 51 min, NRS: 59.79 min; p = 0.005). There were no significant differences in the postoperative complications between the groups. Biochemical cure at six months was achieved in RS: 97.7% and NRS: 93.8% (p = 0.12).

Conclusions: Radioguided MIP is useful in ectopic adenomas and in patients with previous cervical surgery and allows a minimally invasive approach more frequently. It is a safe surgery, easily reproducible by an endocrine surgeon and requires usual equipment found in operating rooms.

目的:评价放射引导入路对腺瘤和微创甲状旁腺切除术(MIP)的术中检出率是否更高,对甲状旁腺瘤继发性甲状旁腺功能亢进的治愈率相同或更好。方法:这是一项观察性、前瞻性、单中心研究,在2017年至2022年期间,连续纳入254例原发性甲状旁腺功能亢进患者。共进行258例手术:129例非放射引导(NRS)和129例放射引导(RS)(112例静脉注射99mtc - MIBI, 17例超声引导下病灶内注射99mtc - maa),术中使用伽马探针和伽马照相机。随访至少一年。结果:两组患者在年龄、性别、术前钙或甲状旁腺激素水平、99mtc - mibi - x线和超声诊断的腺瘤定位、手术发病率等方面均无差异。两组术中手术定位率均为97.7%。支持RS的统计学差异:允许执行MIP (RS: 96.9%, NRS: 88.4%;p = 0.015),既往颈部手术患者亦如此(RS: 75%, NRS: 28%;p = 0.019)和异位腺瘤(RS: 93.3%, NRS: 71.4%;p = 0.012)。手术时间明显缩短(RS: 51 min)。,平均用时59.79分钟;p = 0.005)。两组术后并发症发生率无明显差异。6个月生化治愈率为97.7%,NRS为93.8% (p = 0.12)。结论:放射引导下的MIP在异位腺瘤和既往宫颈手术患者中是有用的,并且更频繁地允许微创入路。这是一种安全的手术,容易被内分泌外科医生复制,只需要手术室里常见的设备。
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引用次数: 0
Current obesity treatment: A story about beliefs, devotion and confrontation. 当前的肥胖治疗:一个关于信仰、奉献和对抗的故事。
Pub Date : 2024-12-19 DOI: 10.1016/j.cireng.2024.11.012
José María Balibrea, María Recarte-Rico, María Dolores Frutos
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引用次数: 0
Preoperative management of patients with oesophageal cancer: Expert recommendations. 食管癌患者的术前管理:专家建议。
Pub Date : 2024-12-18 DOI: 10.1016/j.cireng.2024.12.003
Marcos Bruna Esteban, Rocío Pérez Quintero, M Asunción Acosta Mérida, Aitana García Tejero

The aim of this work is to establish recommendations for the preoperative evaluation and selection of patients with malignant oesophageal neoplasms, who are candidates for surgical resection with curative intent, based on the consensus established by a group of experts. Using the Delphi methodology and after 2 rounds of evaluation, responses were obtained from 37 experts to 47 questions about the preoperative management of oesophageal cancer, considering consensus if there was a mean score greater than 8 (range between 0-10). Of the respondents, 54% were women, with a mean age of 50.2 years, with more than 15 years of average experience in oesophageal surgery. In the preoperative evaluation, agreement was obtained on most of the recommendations, with the indication of a staging laparoscopy being the only one where it was not reached. In the preoperative optimisation, agreement was reached on nutritional, anaemia, physical status, respiratory and comorbidities evaluation, but no agreement was reached on recommending immunonutrition or echocardiography routinely. In the inoperability criteria were included ECOG greater than 1, impaired lung function, and/or Child B or C liver cirrhosis. Agreement was reached on considering unresectable tumours with invasion of the tracheobronchial tract, large vessels, and spinal column, multivisceral metastases, and/or peritoneal carcinomatosis. Therefore, the recommendations established in this manuscript may be useful to support decision-making in daily clinical practice, with a high degree of consensus that decisions regarding the management of these patients should be made on an individual basis and within a multidisciplinary committee of experts.

这项工作的目的是建立建议的术前评估和选择恶性食管肿瘤患者,谁是候选人的手术切除的治愈意图,基于专家组建立的共识。采用德尔菲法,经过2轮评估,获得37位专家对47个关于食管癌术前管理的问题的回答,如果平均得分大于8分(范围0 ~ 10分),则考虑一致。受访者中,54%为女性,平均年龄50.2岁,平均有15年以上的食道手术经验。在术前评估中,大多数建议是一致的,只有分期腹腔镜检查的指征是唯一没有达到的。在术前优化中,对营养、贫血、身体状况、呼吸和合并症的评估达成一致,但在推荐免疫营养或常规超声心动图方面未达成一致。不可操作性标准包括ECOG大于1,肺功能受损,和/或儿童乙型或丙型肝硬化。对于不能切除的肿瘤,如侵犯气管支气管、大血管和脊柱、多脏器转移和/或腹膜癌,我们达成了一致意见。因此,本文中建立的建议可能有助于支持日常临床实践中的决策,关于这些患者的管理决策应在个人基础上并在多学科专家委员会内做出的高度共识。
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引用次数: 0
Response Letter to the Article: "Expanding horizons of indocyanine green in breast surgery". 对文章“拓展吲哚菁绿在乳房手术中的应用”的回复函。
Pub Date : 2024-12-17 DOI: 10.1016/j.cireng.2024.12.002
Eugenio Licardie, Salvador Morales-Conde
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引用次数: 0
Patient safety, why is it important? 患者安全,为什么很重要?
Pub Date : 2024-12-17 DOI: 10.1016/j.cireng.2024.11.010
Javier García Septiem, Alba Correa Bonito
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引用次数: 0
Results at one year of the TROPIS technique in the treatment of complex anal fistula. 结果:TROPIS技术治疗复杂性肛瘘1年。
Pub Date : 2024-12-17 DOI: 10.1016/j.cireng.2024.12.001
María Luisa Reyes Díaz, Fatima Hinojosa-Ramirez, Irene María Ramallo Solís, Rosa María Jiménez Rodríguez, Jose Pintor Tortolero, Ana María García Cabrera, Jorge M Vázquez Monchul, Fernando de la Portilla de Juan

Introduction: It is a priority to find surgical techniques that guarantee acceptable healing rates without sequelae in the treatment of complex anal fistula. The concept of the deep intersphincteric space as the origin of perianal sepsis has provided a new perspective, allowing the emergence of techniques such as TROPIS (Transanal Opening of Intersphincteric Space), with few published series to date. The aim of this study is to evaluate the healing rate and complications one year after the TROPIS technique as a treatment for complex anal fistula without hospitalization.

Method: Prospective, observational study from January 2021 to January 2023. Patients with complex anal fistulas who met the inclusion criteria were treated using the TROPIS technique. A one-year follow up review was conducted, assessing healing rates, recurrence, continence, and complications.

Results: A total of 23 patients with cryptoglandular complex perianal fistula were included (87% male, mean age 54.7 ± 9.6 years). 78.3% were treated for recurrent fistulas with an average of 3.3 ± 3.2 previous interventions. At one month, 82.6% of the patients had complete healing. At three, six, and twelve months, complete healing occurred in 63.6%, 61.9%, and 55.6%, respectively. One patient developed an abscess at one month. Continence was altered in 8.7%.

Conclusions: The treatment of cryptoglandular complex anal fistula with this procedure was safe and showed acceptable healing rates.

导言:在治疗复杂性肛瘘时,当务之急是找到能保证可接受愈合率且不留后遗症的手术技术。括约肌间隙深部是肛周败血症的起源这一概念提供了一个新的视角,使 TROPIS(经肛门括约肌间隙开放)等技术得以出现,但迄今为止发表的系列文章很少。本研究旨在评估 TROPIS 技术治疗复杂性肛瘘一年后的愈合率和并发症,无需住院。符合纳入标准的复杂性肛瘘患者接受 TROPIS 技术治疗。结果:共纳入 23 名隐腺体复杂性肛周瘘患者(87% 为男性,平均年龄(54.7 ± 9.6)岁)。78.3%的患者因复发性肛瘘接受过治疗,平均治疗次数为(3.3 ± 3.2)次。一个月后,82.6%的患者完全愈合。三个月、六个月和十二个月后,分别有 63.6%、61.9% 和 55.6% 的患者完全愈合。一名患者在一个月时出现脓肿。结论:用这种方法治疗隐腺体复杂性肛瘘是安全的,愈合率也是可以接受的。[引言:在治疗复杂性肛瘘时,当务之急是找到能保证可接受愈合率且不留后遗症的手术技术。括约肌间隙深部是肛周败血症的起源,这一概念提供了一个新的视角,使 TROPIS(经肛门打开括约肌间隙)等技术得以出现,但迄今为止发表的系列文章很少。本研究旨在评估 TROPIS 技术治疗复杂性肛瘘一年后的治愈率和并发症。方法:2021 年 1 月至 2023 年 1 月的前瞻性观察研究。对符合纳入标准的复杂性肛瘘患者采用 TROPIS 技术进行治疗。结果:共纳入 23 名隐腺体复杂性肛瘘患者(87% 为男性,平均年龄为 54.7 +/- 9.6 岁)。78.3%的患者为复发性肛瘘,之前平均接受过 3.3+/- 3.2 次治疗。一个月后,82.6%的患者完全治愈。三个月、六个月和十二个月后,分别有 63.6%、61.9% 和 55.6% 的患者完全治愈。一名患者在一个月时出现脓肿。8.7%的患者恢复了连续性:采用这种方法治疗隐腺体复杂性肛瘘是安全的,治愈率也是可以接受的。
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引用次数: 0
Failure to rescue in intrahepatic cholangiocarcinoma. SPAIC project. 肝内胆管癌抢救失败。SPAIC项目。
Pub Date : 2024-12-16 DOI: 10.1016/j.cireng.2024.11.006
Jose M Ramia, Celia Villodre, Beatriz Villota-Tamayo, Cándido Alcazar, Mariano Franco
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Cirugia espanola
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