Ibrain最新文献

Sun Y-F, Huang M, Qin H-Y, et al. Protective effect of isoflurane preconditioning on neurological function in rats with HIE. ibrain. 2022;8:500-515. doi:10.1002/ibra.12081

In ETHICS STATEMENT section, “This study was approved by the Ethics Committee of Kunming Medical University (reference number: kmmu 20220748). The experimental protocol was established according to the ethical guidelines of the Declaration of Helsinki, in accordance with the ARRIVE guidelines in terms of ethical approval and consent to participate, and all methods were performed in accordance with relevant guidelines and regulations.” was inaccurate.

This statement should be corrected as “This study was approved by the Ethics Committee of Kunming Medical University (reference number: kmmu 20220748).”

We apologize for this error.

Neuroinflammation induced by engulfment of synapses by phagocytic microglia plays a crucial role in neuropathic pain. Stauntonia chinensis is extracted from Stauntonia chinensis DC, which has been used as a traditional Chinese medicine to control trigeminal neuralgia or sciatica. However, the specific anti-neuralgia mechanism of Stauntonia chinensis is unknown. In this study, the analgesic effect of Stauntonia chinensis injection (SCI) in mice with neuropathic pain and the possible mechanisms are explored. We find that a local injection of 0.1 mL Stauntonia chinensis for 14 days can considerably relieve mechanical hyperalgesia and thermal hyperalgesia in mice with sciatic chronic constriction injury (CCI). Immunofluorescence staining shows that SCI reduces neuroinflammation in the spinal cord of CCI mice. RNA sequencing reveals that the expression of postsynaptic density protein 95 (PSD-95), a postsynaptic scaffold protein, is downregulated in the spinal cord of CCI mice, but upregulated after SCI administration. Immunofluorescence experiments also demonstrate that SCI administration reverses microglia proliferation and PSD-95 downregulation in CCI mice. These data suggest that SCI relieves neuropathic pain by increasing the expression of PSD-95 and reducing the proliferation of phagocytic microglia.

Tan D-D, Gu J, Li J, et al. The effective doses of remimazolam besylate in the procedural sedation of endoscopic retrograde cholangiopancreatography. ibrain. 2023;9:290-297. doi:10.1002/ibra.12072

In “CONFLICT OF INTEREST” section, the text “Jin Tian is a member of Ibrain's editorial board, but is not involved in the peer-review process of this article. The remaining authors declare no conflict of interest.” was inaccurate.

The correct statement in the CONFLICT OF INTEREST section should be presented as “Jin Tian is a member of Ibrain's editorial board, but is not involved in the peer-review process of this article. Guo-Hua Zhu is affiliated with Yichang Humanwell Pharmaceutical Co., Ltd, Yichang, Hubei, China. He confirms that he has no commercial and other conflicting interests that could be produced from this manuscript. The remaining authors declare no conflict of interest.”

We apologize for this error.

Cerebral organoids have emerged as a powerful tool for mirroring the brain developmental processes and replicating its unique physiology. This bibliometric analysis aims to delineate the burgeoning trends in the application of cerebral organoids in disease research and offer insights for future investigations. We screened all relevant literature from the Web of Science on cerebral organoids in disease research during the period 2013–2022 and analyzed the research trends in the field using VOSviewer, CiteSpace, and Scimago Graphica software. According to the search strategy, 592 articles were screened out. The United States of America (USA) was the most productive, followed by China and Germany. The top nine institutions in terms of the number of publications include Canada and the United States, with the University of California, San Diego (USA), having the highest number of publications. The International Journal of Molecular Sciences was the most productive journal. Knoblich, Juergen A., and Lancaster, Madeline A. published the highest number of articles. Keyword cluster analysis showed that current research trends focused more on induced pluripotent stem cells to construct organoid models of cerebral diseases and the exploration of their mechanisms and therapeutic modalities. This study provides a comprehensive summary and analysis of global research trends in the field of cerebral organoids in diseases. In the past decade, the number of high-quality papers in this field has increased significantly, and cerebral organoids provide hope for simulating nervous system diseases (such as Alzheimer's disease).

Numerous modalities exist through which the central nervous system (CNS) may sustain injury or impairment, encompassing traumatic incidents, stroke occurrences, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Presently available pharmacological and therapeutic interventions are incapable of restoring or regenerating damaged CNS tissue, leading to substantial unmet clinical needs among patients with CNS ailments or injuries. To address and facilitate the recovery of the impaired CNS, cell-based repair strategies encompass multiple mechanisms, such as neuronal replacement, therapeutic factor secretion, and the promotion of host brain plasticity. Despite the progression of cell-based CNS reparation as a therapeutic strategy throughout the years, substantial barriers have impeded its widespread implementation in clinical settings. The integration of cell technologies with advancements in regenerative medicine utilizing biomaterials and tissue engineering has recently facilitated the surmounting of several of these impediments. This comprehensive review presents an overview of distinct CNS conditions necessitating cell reparation, in addition to exploring potential biomaterial methodologies that enhance the efficacy of treating brain injuries.

Perioperative neurocognitive disorder (PND) is a common complication in the perioperative period, which not only prolongs the hospitalization of patients, increases the cost of treatment, but even increases the postoperative mortality of patients, bringing a heavy burden to families and society. Mechanism exploration involves anesthesia and surgery that lead to microglial activation, promote the synthesis and secretion of inflammatory factors, cause an inflammatory cascade, aggravate nerve cell damage, and lead to cognitive dysfunction. It is believed that microglia-mediated neuroinflammatory responses play a vital role in the formation of PND. Microglia surface receptors are essential mediators for microglia to receive external stimuli, regulate microglial functional status, and carry out intercellular signal transmission. Various microglial surface receptors trigger neuroinflammation, damage neurons, and participate in the development and progression of PND by activating microglia. In this study, the roles of immunoglobulin receptors, chemokine receptors, purinergic receptors, and pattern recognition receptors in microglia surface receptors in PND were reviewed, to provide a reference for the mechanism research, prevention, and treatment of PND.

Li, T.-T., Zhang, L.-C., Xiong, L.-L. and Yu, C.-Y. (2019), Bone marrow mesenchymal stem cells in brain ischemia enhaces axonal regeneration associated with IGF-1. Ibrain, 5: 50-59. https://doi.org/10.1002/j.2769-2795.2019.tb00041.x

The Affiliation of authors (Ting-Ting Li^1#, Lan-Chun Zhang^1#, Liu-Lin Xiong², Chang-Yin Yu^3*; 1. Animal center, Kunming Medical University, Kunming, Yunnan, China.2. Clinical and Health Sciences, University of South Australia, Adelaide 5000, South Australia, Australia.3. Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.#*These authors contributed equally) was incorrect.

The correct Affiliation information of authors is presented as follows:

We apologize for this error.

Li, T.-T. and Yuan, H. (2019), Recent advances in bone marrow stromal cell trans-plantation to animals with spinal cord injury. Ibrain, 5: 9-15. https://doi.org/10.1002/j.2769-2795.2019.tb00033.x

The Affiliation of authors (Ting-Ting Li¹, Hao Yuan^1*; 1. Department of Spinal Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China) was incorrect.

The correct Affiliation information of authors is presented as follows:

Ting-Ting Li^1,2, Hao Yuan^2*

1. Institute of Neurological Disease and Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; 2. Department of Spinal Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China

We apologize for this error.

This study aimed to examine the mediating role of anxiety and depression in the relationship between coping styles and life satisfaction among frontline medical workers during the COVID-19 pandemic. Five hundred and fourteen frontline medical workers from Zunyi were recruited to complete questionnaires, including the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Satisfaction with Life Scale (SWLS), and Simplified Coping Style Questionnaire (SCSQ). SPSS 24.0 was used to measure the characteristics of anxiety, depression, life satisfaction, and coping styles. We found that the prevalence rates of anxiety and depression among study participants were 22.57% and 18.29%, respectively. Besides, anxiety was positively correlated with depression; anxiety and depression were positively correlated with passive coping style but negatively correlated with life satisfaction and active coping style; life satisfaction was positively correlated with active coping style and negatively correlated with passive coping style (all p < 0.001). Moreover, anxiety and depression mediated the relationship between coping styles and life satisfaction. Anxiety accounted for 18.6% of the effect of active coping style and 35.48% of the effect of passive coping style on life satisfaction. Depression accounted for 48.84% of the effect of active coping style and 67.74% of the effect of passive coping style on life satisfaction. The present study provides novel insights into the effect of subclinical anxiety and depression on frontline medical workers in the pandemic area. Anxiety and depression yielded a mediating effect on the relationship between coping styles and life satisfaction.