For the first time, the article presents the Quantum Theory of Gravity, covering not only the microcosm of elementary particles, but also the macrocosm of planets, stars and black holes. This relational approach to gravity was consistently presented in Arthur Eddington's monograph “Fundamental Theory”. In the theory of quantum gravity proposes to consider instead of gravity holes in the curved space-time of Einstein's general relativity, gravitational funnels formed by the rotation of planets, stars and galaxies in a dark matter halo. The change in the gravitational potential in the funnels occurs instantly in all areas of the gravitational funnel space in accordance with the pressure gradient described by the Euler-Bernoulli equation for superfluid continuous media. The new cosmological theory represents the evolution of the universe and dark holes without a singularity. The disordered alternation of the processes of contraction and expansion of individual regions of the infinite Universe realizes the circulation of baryonic and dark matter, which allows it to exist indefinitely, bypassing the state of equilibrium. Numerical modeling allows us to assert that the theory of quantum gravity is the most reliable of the three generally accepted theories of gravity.
{"title":"Quantum Theory of Gravity and Arthur Eddingtons Fundamental Theory","authors":"K. Si","doi":"10.37871/jbres1353","DOIUrl":"https://doi.org/10.37871/jbres1353","url":null,"abstract":"For the first time, the article presents the Quantum Theory of Gravity, covering not only the microcosm of elementary particles, but also the macrocosm of planets, stars and black holes. This relational approach to gravity was consistently presented in Arthur Eddington's monograph “Fundamental Theory”. In the theory of quantum gravity proposes to consider instead of gravity holes in the curved space-time of Einstein's general relativity, gravitational funnels formed by the rotation of planets, stars and galaxies in a dark matter halo. The change in the gravitational potential in the funnels occurs instantly in all areas of the gravitational funnel space in accordance with the pressure gradient described by the Euler-Bernoulli equation for superfluid continuous media. The new cosmological theory represents the evolution of the universe and dark holes without a singularity. The disordered alternation of the processes of contraction and expansion of individual regions of the infinite Universe realizes the circulation of baryonic and dark matter, which allows it to exist indefinitely, bypassing the state of equilibrium. Numerical modeling allows us to assert that the theory of quantum gravity is the most reliable of the three generally accepted theories of gravity.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91250951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In dark days of Europe, which was a barren science, you saw the world through superstitions of alchemy and methods based on ignorance and speculation. A current of science emerged in medieval world that provided a new definition of science. In modern definition of science, it is knowledge of fixed truths of nature, man and society, which you have acquired with the tools of empirical intellect and by observation and induction, and which have been useful for ensuring the welfare and security of human beings. The background of this scientific current is call to reason, realism and philosophy. The intellect is source of knowledge of world, and the dimensions of the universe are based on principles of philosophy and method of realism. Sarton, leader of historiography of science in middle Ages, introduced Muslims as leaders of science in middle Ages. A collection of health, food, medicine and theoretical treatments is attributed to Muhammad, which has been published under the title of Prophetic Medicine. Ibn Khaldu criticized medicine of Prophet eight hundred years ago. he writes that Prophet was not a physician and a specialist in worldly affairs, and that use of Prophet's medicine does not require observance of status of prophethood The hypothesis of the present study is that despite Ibn Khaldun's criticism, the realism of the Prophet's medical works shows that Prophet's medicine needs new reflection and study, and a special type of medicine is based on trust in divine wisdom in creating an intelligent system between disease and medicine in nature. The present study has analyzed and explained realism in Prophet's medical words about fenugreek and has shown and proved it according to modern medical data. The Prophet issued a general decree regarding fenugreek and said; Hundreds of new laboratory and clinical research in medicine, veterinary medicine, agriculture, biology show general effectiveness of fenugreek in maintaining human health, livestock, nature and environment, and fenugreek is at heart of biology research, which Proves realism of comprehensive speech of Prophet.
{"title":"Medieval Scientific Policy in Medicine, Measuring Realism in Prophet Medicine","authors":"Mohammadreza Shahidipak","doi":"10.37871/jbres1390","DOIUrl":"https://doi.org/10.37871/jbres1390","url":null,"abstract":"In dark days of Europe, which was a barren science, you saw the world through superstitions of alchemy and methods based on ignorance and speculation. A current of science emerged in medieval world that provided a new definition of science. In modern definition of science, it is knowledge of fixed truths of nature, man and society, which you have acquired with the tools of empirical intellect and by observation and induction, and which have been useful for ensuring the welfare and security of human beings. The background of this scientific current is call to reason, realism and philosophy. The intellect is source of knowledge of world, and the dimensions of the universe are based on principles of philosophy and method of realism. Sarton, leader of historiography of science in middle Ages, introduced Muslims as leaders of science in middle Ages. A collection of health, food, medicine and theoretical treatments is attributed to Muhammad, which has been published under the title of Prophetic Medicine. Ibn Khaldu criticized medicine of Prophet eight hundred years ago. he writes that Prophet was not a physician and a specialist in worldly affairs, and that use of Prophet's medicine does not require observance of status of prophethood The hypothesis of the present study is that despite Ibn Khaldun's criticism, the realism of the Prophet's medical works shows that Prophet's medicine needs new reflection and study, and a special type of medicine is based on trust in divine wisdom in creating an intelligent system between disease and medicine in nature. The present study has analyzed and explained realism in Prophet's medical words about fenugreek and has shown and proved it according to modern medical data. The Prophet issued a general decree regarding fenugreek and said; Hundreds of new laboratory and clinical research in medicine, veterinary medicine, agriculture, biology show general effectiveness of fenugreek in maintaining human health, livestock, nature and environment, and fenugreek is at heart of biology research, which Proves realism of comprehensive speech of Prophet.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74298835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Haider, A. Haider, Bushra Bano, R. Khan, Nausheen Bukhari, A. Alrahlah
In implant and trauma surgery, implant-related infections are a significant problem. Implant-related infections are becoming more common with the increase in implant procedures. Implantation of implants has become a common and life-saving surgery. The number of hip surgeries performed worldwide is one million per year, and the number of knee surgeries exceeds 250000. More than 30% of hospital patients have one or more vascular catheters that need repair. More than 10% of hospital patients have a fixed urinary catheter. Approximately 2 million nosocomial infections cost over $11 billion each year in the United States. One of the most important risk factors is exposure to intrusive medical devices. Current treatment approaches have serious consequences for individuals and often fail to eradicate the disease. The increased likelihood of infections becoming chronic is due to effective bacterial evasion tactics, with biofilm formation being an important factor in bacterial persistence. The presence of foreign material promotes biofilm formation, contributing to the persistence of infection. Therefore, there is great interest in eradicating the disease in the planktonic phase (free-swimming bacteria) before biofilm transformation occurs and avoiding reinfection after antibiotic or surgical therapy. This mini-review reviews the literature on the implant, associated infections, their mechanism, and strategies used to prevent these infections.
{"title":"Microbial Biofilm Infections in Tissue Implant: A Review","authors":"S. Haider, A. Haider, Bushra Bano, R. Khan, Nausheen Bukhari, A. Alrahlah","doi":"10.37871/jbres1365","DOIUrl":"https://doi.org/10.37871/jbres1365","url":null,"abstract":"In implant and trauma surgery, implant-related infections are a significant problem. Implant-related infections are becoming more common with the increase in implant procedures. Implantation of implants has become a common and life-saving surgery. The number of hip surgeries performed worldwide is one million per year, and the number of knee surgeries exceeds 250000. More than 30% of hospital patients have one or more vascular catheters that need repair. More than 10% of hospital patients have a fixed urinary catheter. Approximately 2 million nosocomial infections cost over $11 billion each year in the United States. One of the most important risk factors is exposure to intrusive medical devices. Current treatment approaches have serious consequences for individuals and often fail to eradicate the disease. The increased likelihood of infections becoming chronic is due to effective bacterial evasion tactics, with biofilm formation being an important factor in bacterial persistence. The presence of foreign material promotes biofilm formation, contributing to the persistence of infection. Therefore, there is great interest in eradicating the disease in the planktonic phase (free-swimming bacteria) before biofilm transformation occurs and avoiding reinfection after antibiotic or surgical therapy. This mini-review reviews the literature on the implant, associated infections, their mechanism, and strategies used to prevent these infections.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"251 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76343598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Employers increasingly focus on absence benefits and connections with employee health. United States absence benefits include Sick Leave (SL), Short- and Long-Term Disability (STD and LTD, respectively) for non-work-related injuries/illnesses, and Workers’ Compensation (WC) for work-related injuries/illnesses. This research explores all-cause absence (SL, STD, LTD, and WC) utilization and changes from baseline for eligible employees with rheumatoid arthritis to determine if the use a constant payment factor is appropriate for models. Study Design: Retrospective multi-year database analysis. Methods: The Workpartners database (1/1/2001-12/31/2019) was used to identify employees with rheumatoid arthritis with adjudicated medical claims. Annual prevalence, benefit utilization, mean days of leave, and median payments (as % of salary) were analyzed. Annual outcomes were calculated as a percent of baseline (2001). Results: Rheumatoid arthritis prevalence averaged 0.5% between 2001 and 2019. At baseline, the percent of eligible employees using STD = 15.5%, LTD = 0.7%, WC = 1.7%, SL = 61.7%. Mean absence days were 48.5, 367.5, 43.8 for STD, LTD, WC, respectively and median payments were 70.5%, 22.2%, 65.7% of salary for STD, LTD, WC, respectively. From 2002-2019: 11.7%-16.9% of eligible employees filed STD claims for 82.1%-995.9% of baseline days and 80.4%-125.9% median payments; 0.6%-2.9% of eligible employees filed LTD claims for 66.6%-114.7% of baseline days and 63.2%-254.8% median payments; 0.3%-1.6% of eligible employees filed WC claims for 44.0%-472.8% of baseline days and 70.4%-271.5% median payments. Median payments were highest in 2012, 2019, 2003 for STD, LTD, WC, respectively and the most absence days were used in 2017 for SL and LTD, 2008 for STD, and 2005 WC. Conclusion: Employees with rheumatoid arthritis used absence benefits at differing rates over time with varying leave-lengths and payments. Using a constant cost or salary replacement factor for absence costs over time and across benefits is not accurate.
{"title":"Rheumatoid Arthritis Disability and Absence Trends in the United States","authors":"R. Brook, N. Kleinman, I. Beren","doi":"10.37871/jbres1378","DOIUrl":"https://doi.org/10.37871/jbres1378","url":null,"abstract":"Objectives: Employers increasingly focus on absence benefits and connections with employee health. United States absence benefits include Sick Leave (SL), Short- and Long-Term Disability (STD and LTD, respectively) for non-work-related injuries/illnesses, and Workers’ Compensation (WC) for work-related injuries/illnesses. This research explores all-cause absence (SL, STD, LTD, and WC) utilization and changes from baseline for eligible employees with rheumatoid arthritis to determine if the use a constant payment factor is appropriate for models. Study Design: Retrospective multi-year database analysis. Methods: The Workpartners database (1/1/2001-12/31/2019) was used to identify employees with rheumatoid arthritis with adjudicated medical claims. Annual prevalence, benefit utilization, mean days of leave, and median payments (as % of salary) were analyzed. Annual outcomes were calculated as a percent of baseline (2001). Results: Rheumatoid arthritis prevalence averaged 0.5% between 2001 and 2019. At baseline, the percent of eligible employees using STD = 15.5%, LTD = 0.7%, WC = 1.7%, SL = 61.7%. Mean absence days were 48.5, 367.5, 43.8 for STD, LTD, WC, respectively and median payments were 70.5%, 22.2%, 65.7% of salary for STD, LTD, WC, respectively. From 2002-2019: 11.7%-16.9% of eligible employees filed STD claims for 82.1%-995.9% of baseline days and 80.4%-125.9% median payments; 0.6%-2.9% of eligible employees filed LTD claims for 66.6%-114.7% of baseline days and 63.2%-254.8% median payments; 0.3%-1.6% of eligible employees filed WC claims for 44.0%-472.8% of baseline days and 70.4%-271.5% median payments. Median payments were highest in 2012, 2019, 2003 for STD, LTD, WC, respectively and the most absence days were used in 2017 for SL and LTD, 2008 for STD, and 2005 WC. Conclusion: Employees with rheumatoid arthritis used absence benefits at differing rates over time with varying leave-lengths and payments. Using a constant cost or salary replacement factor for absence costs over time and across benefits is not accurate.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75904543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulmageed B Abdullah, Abdulbaki Al-zaemey, Rasheed Hasan Mudhesh Al-Husami, Mofeed Al-Nowihi
The antimicrobial activity about water extract of Acacia etbaica was examined by using agar well diffusion methods against five gram-positive and negative bacteria[Staphylococcus aureus (ATCC653-8), Pseudomonas aeruginosa MTCC2453, Bacillus cereus (ATCC6633), Escherichia coli MTCC739, and one local isolate (Staphylococcus epidermides)] in addition to Candida albicans (ATCC2019). this results designated that the water extract of Acacia etbaica possess antimicrobial efficacy against all tested microorganisms either (gram-positive and negative bacteria) or fungi (Candida albicans).Whereas the gram-positive bacteria (S. aureus, S. epidermides and B. cereus) with inhibition zones (21, 19.5 and 16.5) respectively was more sensitive than gram-negative bacteria (P. aeruginosa and E. coli) and C. albicans with inhibition zones 16 and 14.5 respectively. The antimicrobial effect was directly proportional with concentration of water extract where the highest inhibition zone at higher concentration 30% equal 21mm against S.aureus and the lower inhibition zone at lower concentration 5% equal 10mm against C. albicans...
{"title":"Evaluation of Antimicrobial Activity of Acacia etbaica Water Extract Leafs against Some Pathogenic Microorganisms","authors":"Abdulmageed B Abdullah, Abdulbaki Al-zaemey, Rasheed Hasan Mudhesh Al-Husami, Mofeed Al-Nowihi","doi":"10.37871/jbres1358","DOIUrl":"https://doi.org/10.37871/jbres1358","url":null,"abstract":"The antimicrobial activity about water extract of Acacia etbaica was examined by using agar well diffusion methods against five gram-positive and negative bacteria[Staphylococcus aureus (ATCC653-8), Pseudomonas aeruginosa MTCC2453, Bacillus cereus (ATCC6633), Escherichia coli MTCC739, and one local isolate (Staphylococcus epidermides)] in addition to Candida albicans (ATCC2019). this results designated that the water extract of Acacia etbaica possess antimicrobial efficacy against all tested microorganisms either (gram-positive and negative bacteria) or fungi (Candida albicans).Whereas the gram-positive bacteria (S. aureus, S. epidermides and B. cereus) with inhibition zones (21, 19.5 and 16.5) respectively was more sensitive than gram-negative bacteria (P. aeruginosa and E. coli) and C. albicans with inhibition zones 16 and 14.5 respectively. The antimicrobial effect was directly proportional with concentration of water extract where the highest inhibition zone at higher concentration 30% equal 21mm against S.aureus and the lower inhibition zone at lower concentration 5% equal 10mm against C. albicans...","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80757192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Three-Dimensional Quantitative Structure-Activity Relationship (3D QSAR) models now have a wide range of applications; however, new methodologies are required due to the complexity in understanding their results. This research presents a generalized version of quantum similarity field and chemical reactivity descriptors within the density functional theory framework. By taking reference compounds, this generalized methodology can be used to understand the biological activity of a molecular set. In this sense, this methodology allows to study of the CoMFA in quantum similarity and chemical reactivity. It is feasible to investigate steric and electrostatic effects on local substitutions using this method. They were considering that how these methodologies could be used when the receptor is known or unknown.
{"title":"New Insights to Understand the CoMFA Analysis within the Density Functional Theory Framework","authors":"Roya Momen, A. Morales‐Bayuelo","doi":"10.37871/jbres1349","DOIUrl":"https://doi.org/10.37871/jbres1349","url":null,"abstract":"The Three-Dimensional Quantitative Structure-Activity Relationship (3D QSAR) models now have a wide range of applications; however, new methodologies are required due to the complexity in understanding their results. This research presents a generalized version of quantum similarity field and chemical reactivity descriptors within the density functional theory framework. By taking reference compounds, this generalized methodology can be used to understand the biological activity of a molecular set. In this sense, this methodology allows to study of the CoMFA in quantum similarity and chemical reactivity. It is feasible to investigate steric and electrostatic effects on local substitutions using this method. They were considering that how these methodologies could be used when the receptor is known or unknown.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82232383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The anthropic pressure on natural systems is the main cause for the present process of biodiversity loss in terrestrial biosphere [1]. Really, the human disturbance on Earth affects the 74.1% of terrestrial and marine habitats, including 22.4% completely modified, 51.7% partially disturbed and just the 25.9% in natural and pristine conditions [2]. At the beginning of third millenium, in the middle of a post-industrial era, named “Anthropocene” [3], mankind is causing the greatest mass extinction of wildlife in terrestrial biosphere [4-6].
{"title":"Ecological Networks and Fluvial Corridors in Calabria (Southern Italy)","authors":"N. Cantasano","doi":"10.37871/jbres1385","DOIUrl":"https://doi.org/10.37871/jbres1385","url":null,"abstract":"The anthropic pressure on natural systems is the main cause for the present process of biodiversity loss in terrestrial biosphere [1]. Really, the human disturbance on Earth affects the 74.1% of terrestrial and marine habitats, including 22.4% completely modified, 51.7% partially disturbed and just the 25.9% in natural and pristine conditions [2]. At the beginning of third millenium, in the middle of a post-industrial era, named “Anthropocene” [3], mankind is causing the greatest mass extinction of wildlife in terrestrial biosphere [4-6].","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78380032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Lung cancer is the most common cancer with 2,206,771 new cases in 2020 in worldwide. MMP9 is a member of matrix metalloproteinase family that is also known as gelatinase B or IV type collagenase (92KD). MMP9 through degrading of Extracellular Matrix (ECM) and releasing of growth factors has fundamental role in the tumorigenesis process. The C -1562 T SNP in the MMP9 promoter increases MMP9 expression and susceptibility to lung cancer. Then, the aim of this present case-control study was to investigate whether genetic variations of the MMP9 gene may constitute markers for lung cancer risk in males and in positive family history people in Iran. Methods: This is a case-control study including 120 lung cancer patients and 100 healthy controls. Polymorphism in the C -1562 T region was genotyped by PCR-RFLP assay. Odds Ratio (ORs) and 95% Confidence Intervals (CIs) were estimated by chi-square test from comparison of genotypes between lung cancer patients and healthy controls, using SPSS version 26.0. T-test and Image J software was also used. Results: The distribution of C-1562T genotype was significantly associated with the risk of lung cancer (Odds Ratio [OR] = 2.56, 95% Confidence Interval [CI] = 0.06-23.82). The further stratification analyses shown that males and patients with positive family history may increase risk of lung cancer. Conclusion: Our results indicated that the MMP9 C -1562 T polymorphism affects risk of lung cancer. In addition, men with T allele (OR = 3.94, CI = 1.47-10`.55) and patients with TT genotype and family history (OR = 2.18, CI = 1.03-4.59) exposure to higher risk of lung cancer.
背景:肺癌是最常见的癌症，2020年全球新发病例为2206771例。MMP9是基质金属蛋白酶家族的成员，也被称为明胶酶B或IV型胶原酶(92KD)。MMP9通过降解细胞外基质(Extracellular Matrix, ECM)和释放生长因子在肿瘤发生过程中起着重要作用。MMP9启动子中的C -1562 T SNP增加MMP9的表达和对肺癌的易感性。因此，本病例对照研究的目的是调查MMP9基因的遗传变异是否可能构成伊朗男性和阳性家族史人群肺癌风险的标志物。方法:本研究为病例对照研究，包括120例肺癌患者和100例健康对照。采用PCR-RFLP法对C -1562 T区多态性进行基因分型。肺癌患者与健康对照组基因型比较的优势比(ORs)和95%置信区间(CIs)采用卡方检验，使用SPSS 26.0版本。采用t检验和Image J软件。结果:C-1562T基因型分布与肺癌发生风险显著相关(优势比[OR] = 2.56, 95%可信区间[CI] = 0.06 ~ 23.82)。进一步的分层分析表明，男性和有阳性家族史的患者可能增加肺癌的风险。结论:MMP9 C -1562 T多态性影响肺癌的发生。此外，携带T等位基因的男性(OR = 3.94, CI = 1.47-10’.55)和有TT基因型和家族史的患者(OR = 2.18, CI = 1.03-4.59)暴露于肺癌的风险较高。
{"title":"A Single Nucleotide Polymorphism in the MMP9 Promoter Affects Lung Cancer and Clinicopathological Properties in Iranian Population","authors":"Somayeh Taghvaei, L. Saremi, M. Motovali-bashi","doi":"10.37871/jbres1382","DOIUrl":"https://doi.org/10.37871/jbres1382","url":null,"abstract":"Background: Lung cancer is the most common cancer with 2,206,771 new cases in 2020 in worldwide. MMP9 is a member of matrix metalloproteinase family that is also known as gelatinase B or IV type collagenase (92KD). MMP9 through degrading of Extracellular Matrix (ECM) and releasing of growth factors has fundamental role in the tumorigenesis process. The C -1562 T SNP in the MMP9 promoter increases MMP9 expression and susceptibility to lung cancer. Then, the aim of this present case-control study was to investigate whether genetic variations of the MMP9 gene may constitute markers for lung cancer risk in males and in positive family history people in Iran. Methods: This is a case-control study including 120 lung cancer patients and 100 healthy controls. Polymorphism in the C -1562 T region was genotyped by PCR-RFLP assay. Odds Ratio (ORs) and 95% Confidence Intervals (CIs) were estimated by chi-square test from comparison of genotypes between lung cancer patients and healthy controls, using SPSS version 26.0. T-test and Image J software was also used. Results: The distribution of C-1562T genotype was significantly associated with the risk of lung cancer (Odds Ratio [OR] = 2.56, 95% Confidence Interval [CI] = 0.06-23.82). The further stratification analyses shown that males and patients with positive family history may increase risk of lung cancer. Conclusion: Our results indicated that the MMP9 C -1562 T polymorphism affects risk of lung cancer. In addition, men with T allele (OR = 3.94, CI = 1.47-10`.55) and patients with TT genotype and family history (OR = 2.18, CI = 1.03-4.59) exposure to higher risk of lung cancer.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89036424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Pantaleon, A. Fukushima, L. R. de Paula, G. Ribeiro, Beatriz do Prado Pacca, Juliana Weckx Peña Muñoz, H. de Souza Spinosa, E. Ricci
Herbicides represent the largest portion of pesticides used both worldwide and in Brazil. Many of these compounds are applied on a large scale in native forests and in urban and industrial water environments, including atrazine. Due to its low cost, ability to remain active in the soil for long periods and potential effect on weed removal, atrazine ranks 5th in the ranking of most used pesticide in Brazil. Although the use of pesticides increases agricultural production, their intensive use can often cause negative effects on fauna and flora. Studies have shown that exposure to atrazine can cause various harmful effects in mammals, of both sexes, such as structural, neuroendocrine and/or behavioral changes. Considering the seriousness of the situation and the possible toxicological and pathological implications that atrazine can generate in the animal organism, the objective of this work was to carry out an integrative literature review in order to verify the scientific panorama on issues related to atrazine exposure and its impacts, mainly with regard to its toxicity on the central nervous system. To carry out this article, a bibliographic survey of scientific material obtained in the following databases was carried out: US National Library of Medicine - National Institutes of Health (PubMed), Virtual Health Library (Latin American and Caribbean Literature in Health Sciences - LILACS), Science Direct and Google® Academic, in the last 25 years. The MeSH Terms used in the search were: “Parkinson's disease”, “atrazine”, “herbicide” and “endocrine disruptor”. The following were found in the Science Direct indexers: 115 records, PubMed 52 records, in LILACS no articles were found, and 1330 records were found in Google® Academic.
{"title":"Integrative Review Verification of the Influence of Atrazine Exposure on Behavioral, Neurochemical and Parkinsons Disease Disorders","authors":"L. Pantaleon, A. Fukushima, L. R. de Paula, G. Ribeiro, Beatriz do Prado Pacca, Juliana Weckx Peña Muñoz, H. de Souza Spinosa, E. Ricci","doi":"10.37871/jbres1347","DOIUrl":"https://doi.org/10.37871/jbres1347","url":null,"abstract":"Herbicides represent the largest portion of pesticides used both worldwide and in Brazil. Many of these compounds are applied on a large scale in native forests and in urban and industrial water environments, including atrazine. Due to its low cost, ability to remain active in the soil for long periods and potential effect on weed removal, atrazine ranks 5th in the ranking of most used pesticide in Brazil. Although the use of pesticides increases agricultural production, their intensive use can often cause negative effects on fauna and flora. Studies have shown that exposure to atrazine can cause various harmful effects in mammals, of both sexes, such as structural, neuroendocrine and/or behavioral changes. Considering the seriousness of the situation and the possible toxicological and pathological implications that atrazine can generate in the animal organism, the objective of this work was to carry out an integrative literature review in order to verify the scientific panorama on issues related to atrazine exposure and its impacts, mainly with regard to its toxicity on the central nervous system. To carry out this article, a bibliographic survey of scientific material obtained in the following databases was carried out: US National Library of Medicine - National Institutes of Health (PubMed), Virtual Health Library (Latin American and Caribbean Literature in Health Sciences - LILACS), Science Direct and Google® Academic, in the last 25 years. The MeSH Terms used in the search were: “Parkinson's disease”, “atrazine”, “herbicide” and “endocrine disruptor”. The following were found in the Science Direct indexers: 115 records, PubMed 52 records, in LILACS no articles were found, and 1330 records were found in Google® Academic.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"344 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74103005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. K. Drokow, C. Effah, Clement Agboyibor, G. Akpabla, Kai Sun
Cervical cancer if not detected and treated promptly can be lethal to females. In several advanced nations, the relevance of coordinated screening services has been implemented. Nevertheless, most developing nations have not implemented a nationwide screening and vaccination programme accessible to all women owing to inadequate screening and vaccination services coupled with vaccine scepticism, misconception concerning vaccination, and lack of awareness are causing an upsurge in Africa's cervical cancer cases. Cervical cancer could be greatly reduced if comprehensive screening services and HPV vaccination are implemented. In this review, we discussed the cervical cancer incidence in Africa, factors influencing the high rate of cervical cancer in Africa, screening and HPV vaccination programs and the potential intervention and recommendations to reduce the incident and mortality rates of cervical cancer in Africa. Also, we highlighted the disadvantages and advantages of widely accessible screening tests in Africa.
{"title":"The State of Cervical Cancer Screening and HPV Vaccination in Africa: In the Advent of Advanced Health Care","authors":"E. K. Drokow, C. Effah, Clement Agboyibor, G. Akpabla, Kai Sun","doi":"10.37871/jbres1341","DOIUrl":"https://doi.org/10.37871/jbres1341","url":null,"abstract":"Cervical cancer if not detected and treated promptly can be lethal to females. In several advanced nations, the relevance of coordinated screening services has been implemented. Nevertheless, most developing nations have not implemented a nationwide screening and vaccination programme accessible to all women owing to inadequate screening and vaccination services coupled with vaccine scepticism, misconception concerning vaccination, and lack of awareness are causing an upsurge in Africa's cervical cancer cases. Cervical cancer could be greatly reduced if comprehensive screening services and HPV vaccination are implemented. In this review, we discussed the cervical cancer incidence in Africa, factors influencing the high rate of cervical cancer in Africa, screening and HPV vaccination programs and the potential intervention and recommendations to reduce the incident and mortality rates of cervical cancer in Africa. Also, we highlighted the disadvantages and advantages of widely accessible screening tests in Africa.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87368261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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