Alessandro Scarano, Roberto Luongo, Mario Rampino, E. Pedullá, C. Bugea
Despite validated surgical techniques and the development of biomaterials, the procedures aimed at increasing the maxillary bone volume by sinus floor elevation have complications with various degrees of relevance. The perforation of the Schneiderian membrane is one of the most frequent events while performing the detachment of the membrane and it can increase the risk of iatrogenic sinusitis, impairment of functional homeostasis, dispersion of the graft material in the antral cavity as well as its bacterial colonization with a subsequential failure of the procedure. This report presents a case where transcrestal sinus lift was performed using Flusilift (Sweden & Martina, Due Carrare PD), a new instrument that allows fluid dynamic elevation of the sinus floor using saline solution to detach the Schneider’s membrane in an atraumatic way without using a sinus elevator and obtain an adequate alveolar ridge regeneration using hyaluronic acid in gel formulation to support an implant placement. Hyaluronic acid seems to play a key role in wound healing and contributes to a faster bone neoformation in bone regeneration procedures.
尽管经过验证的外科技术和生物材料的发展，旨在通过窦底提升增加上颌骨体积的手术有不同程度的相关并发症。施耐德膜穿孔是进行膜剥离时最常见的事件之一，它可以增加医源性鼻窦炎的风险，损害功能稳态，移植物在窦腔中的分散以及随后手术失败的细菌定植。本报告介绍了一个使用Flusilift(瑞典和Martina, Due Carrare PD)进行跨瓣窦提升的病例，这是一种新型器械，可以使用生理盐水溶液以无创伤的方式将窦底流体动力提升，以分离施耐德膜，而无需使用窦提升器，并使用透明质酸凝胶配方获得足够的牙槽嵴再生，以支持植入物的放置。透明质酸似乎在伤口愈合中起关键作用，并有助于骨再生过程中更快的骨新生。
{"title":"Fluid Dynamic Transcrestal Sinus Floor Elevation Using a New Surgical Instrument, Flusilift and Hyaluronic Acid as Only Biomaterial: A Case Report","authors":"Alessandro Scarano, Roberto Luongo, Mario Rampino, E. Pedullá, C. Bugea","doi":"10.37871/jbres1381","DOIUrl":"https://doi.org/10.37871/jbres1381","url":null,"abstract":"Despite validated surgical techniques and the development of biomaterials, the procedures aimed at increasing the maxillary bone volume by sinus floor elevation have complications with various degrees of relevance. The perforation of the Schneiderian membrane is one of the most frequent events while performing the detachment of the membrane and it can increase the risk of iatrogenic sinusitis, impairment of functional homeostasis, dispersion of the graft material in the antral cavity as well as its bacterial colonization with a subsequential failure of the procedure. This report presents a case where transcrestal sinus lift was performed using Flusilift (Sweden & Martina, Due Carrare PD), a new instrument that allows fluid dynamic elevation of the sinus floor using saline solution to detach the Schneider’s membrane in an atraumatic way without using a sinus elevator and obtain an adequate alveolar ridge regeneration using hyaluronic acid in gel formulation to support an implant placement. Hyaluronic acid seems to play a key role in wound healing and contributes to a faster bone neoformation in bone regeneration procedures.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81255550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The joint interest of clinicians and the laboratory test industry during the recent pandemic of the Coronavirus Disease 2019 (COVID-19) resulted in an explosion of accessible assays for COVID-19 serological testing. Content: The need of properly evaluated laboratory tests is more apparent today than ever before. Clinical application of the assay, analytical specifications, and performance convenience are the key criteria that must be followed while selecting an analytical method. An analytical evaluation is always performed before deciding to apply a procedure in the laboratory routine practice. Summary: Only after the evaluation, data collection, and analysis of the results in accordance with the established eligibility criteria can be concluded that the new assay is suitable for laboratory use.
{"title":"The Importance of Expertly Evaluated Tests Underlined by COVID-19 Pandemic: A Mini Review","authors":"D. Šegulja","doi":"10.37871/jbres1369","DOIUrl":"https://doi.org/10.37871/jbres1369","url":null,"abstract":"Background: The joint interest of clinicians and the laboratory test industry during the recent pandemic of the Coronavirus Disease 2019 (COVID-19) resulted in an explosion of accessible assays for COVID-19 serological testing. Content: The need of properly evaluated laboratory tests is more apparent today than ever before. Clinical application of the assay, analytical specifications, and performance convenience are the key criteria that must be followed while selecting an analytical method. An analytical evaluation is always performed before deciding to apply a procedure in the laboratory routine practice. Summary: Only after the evaluation, data collection, and analysis of the results in accordance with the established eligibility criteria can be concluded that the new assay is suitable for laboratory use.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73239269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Akram, Waqas Ahmed, Abolfazl Jafari-Sales, NilgünKu, çulu, Mounir Bekhit, Prakash Ramakrishnan, El Hadji, S. Mbaye, F. Khan, O. Kilic, M. Amjad, Chishti, A. Sharif, M. Muddasar, Saeed, W. Elkhateeb, G. Daba
Background: As the world witnessed the outbreak of coronavirus illness 2019 (COVID-19), a disorder developed as a result of a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), increasing genetics with healthcare evidence suggest a corresponding leadership to SARS as well as the Middle East Respiratory Syndrome (MERS). Aim: The aim of this review is to highlight Immune response of human body toward COVID-19. Materials and methods: This was a narrative review. A comprehensive literature search was done using PubMed, Google Scholar, Scopus, and EMBASE using the keywords, Immune Response; COVID-19; Vaccination; SARS-Cov-2; ACE2; Coronavirus; MERS. Results: A flow of viral components passes to the body by means of nostrils, mouth and eyes. SARS-CoV-2 is in a position to continue to become unnoticed extended than numerous influenza or coronaviruses. Its proteins can accomplish entry by unlocking the Angiotensin-Converting Enzyme 2 (ACE2) protein in the lung cells; viruses also possess antigens furthermore recognize that these are what cries the immunity into movement via making antibodies. Investigators demonstrate an extensive variety of immune cells respond to COVID-19 along with valuable source retrieval, discovering that might want to notify the manufacturing of a viable vaccination. Conclusion: The body's natural response to a viral infection is a non-invasive intrinsic response in which macrophages, neutrophils, and dendritic cells limit the virus's progression and may even prevent it by multiplying symptoms. This non-invasive solution is accompanied by an elastic response in which the body produces radicals that primarily adjust to the herpes virus.
{"title":"Immune Response towards COVID-19","authors":"Muhammad Akram, Waqas Ahmed, Abolfazl Jafari-Sales, NilgünKu, çulu, Mounir Bekhit, Prakash Ramakrishnan, El Hadji, S. Mbaye, F. Khan, O. Kilic, M. Amjad, Chishti, A. Sharif, M. Muddasar, Saeed, W. Elkhateeb, G. Daba","doi":"10.37871/jbres1372","DOIUrl":"https://doi.org/10.37871/jbres1372","url":null,"abstract":"Background: As the world witnessed the outbreak of coronavirus illness 2019 (COVID-19), a disorder developed as a result of a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), increasing genetics with healthcare evidence suggest a corresponding leadership to SARS as well as the Middle East Respiratory Syndrome (MERS). Aim: The aim of this review is to highlight Immune response of human body toward COVID-19. Materials and methods: This was a narrative review. A comprehensive literature search was done using PubMed, Google Scholar, Scopus, and EMBASE using the keywords, Immune Response; COVID-19; Vaccination; SARS-Cov-2; ACE2; Coronavirus; MERS. Results: A flow of viral components passes to the body by means of nostrils, mouth and eyes. SARS-CoV-2 is in a position to continue to become unnoticed extended than numerous influenza or coronaviruses. Its proteins can accomplish entry by unlocking the Angiotensin-Converting Enzyme 2 (ACE2) protein in the lung cells; viruses also possess antigens furthermore recognize that these are what cries the immunity into movement via making antibodies. Investigators demonstrate an extensive variety of immune cells respond to COVID-19 along with valuable source retrieval, discovering that might want to notify the manufacturing of a viable vaccination. Conclusion: The body's natural response to a viral infection is a non-invasive intrinsic response in which macrophages, neutrophils, and dendritic cells limit the virus's progression and may even prevent it by multiplying symptoms. This non-invasive solution is accompanied by an elastic response in which the body produces radicals that primarily adjust to the herpes virus.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87012403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wangjing Ma, Xiao Tc, Liu Bn, Xu Zc, Jin Zq, Gong Qt
The accelerated UV visible photocatalytic carbon-carbon double bond isomerization of Linear Alpha Olefins (LAO) with 12-Tungstophosphate Acids (12-TPA) as an efficient, environmentally-friendly and recyclable catalyst was described, which produced the corresponding Linear Internal Olefins (LIO) in general high selectivity and high yields.
{"title":"12-Tungstophosphate Acids: An Efficient, Green and Recyclable Photocatalyst in Carbon-Carbon Double Bond Isomerization on Linear Alpha Olefins","authors":"Wangjing Ma, Xiao Tc, Liu Bn, Xu Zc, Jin Zq, Gong Qt","doi":"10.37871/jbres1367","DOIUrl":"https://doi.org/10.37871/jbres1367","url":null,"abstract":"The accelerated UV visible photocatalytic carbon-carbon double bond isomerization of Linear Alpha Olefins (LAO) with 12-Tungstophosphate Acids (12-TPA) as an efficient, environmentally-friendly and recyclable catalyst was described, which produced the corresponding Linear Internal Olefins (LIO) in general high selectivity and high yields.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85959574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Research and publication are relevant from perspectives in the management of local and global health because disease is perspicuously a geopolitical issue ostensibly linked to gain-of-function research where health diplomacy undergirds present and future global functionalities regarding the emergence and reemergence of infectious diseases. These have generated vehement reactions with propensity for extreme geopolitics and gain-of-function natural and anthropogenic activities. Geopolitical parameters and gain-of-function issues impact on the social determinants of health and vice versa. The convening and convergence of countries for unprecedented epidemic or pandemic treaty settings or other formulations to confront emerging and reemerging infectious diseases will afford considerable opportunities concerning challenges in action, preparedness and response. Provisions are pertinent for legal instruments, effective and efficient systems to curb future threats and outbreaks of infectious diseases.
{"title":"Environmental Health Perspectives on the Emergence and Re-Emergence of Infectious Diseases, Geopolitics and Gain of Function Research","authors":"C. Sr","doi":"10.37871/jbres1386","DOIUrl":"https://doi.org/10.37871/jbres1386","url":null,"abstract":"Research and publication are relevant from perspectives in the management of local and global health because disease is perspicuously a geopolitical issue ostensibly linked to gain-of-function research where health diplomacy undergirds present and future global functionalities regarding the emergence and reemergence of infectious diseases. These have generated vehement reactions with propensity for extreme geopolitics and gain-of-function natural and anthropogenic activities. Geopolitical parameters and gain-of-function issues impact on the social determinants of health and vice versa. The convening and convergence of countries for unprecedented epidemic or pandemic treaty settings or other formulations to confront emerging and reemerging infectious diseases will afford considerable opportunities concerning challenges in action, preparedness and response. Provisions are pertinent for legal instruments, effective and efficient systems to curb future threats and outbreaks of infectious diseases.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83652409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Bashir, Nordiana MOHD MUZTAZA, N. Ismail, Ismail Ahmad Abir, A. A. Bery, N. Siddiqui
Seismic data acquired in the field show the subsurface reflectors or horizon among the geological strata, while the seismic inversion converts this reflector information into the acoustic impedance section which shows the layer properties based on lithology. The research aims to predict the porosity to identify the reservoir which is in between the tight layer. So, the output of the seismic inversion is much more batter than the seismic as it is closer to reality such as geology. Seismic inversion is frequently used to determine rock physics properties, for example, acoustic impedance and porosity.
{"title":"Seismic Interpretation and Inversion Leading to an Accurate Reservoir Characterization in a Carbonate Environment","authors":"Y. Bashir, Nordiana MOHD MUZTAZA, N. Ismail, Ismail Ahmad Abir, A. A. Bery, N. Siddiqui","doi":"10.37871/jbres1376","DOIUrl":"https://doi.org/10.37871/jbres1376","url":null,"abstract":"Seismic data acquired in the field show the subsurface reflectors or horizon among the geological strata, while the seismic inversion converts this reflector information into the acoustic impedance section which shows the layer properties based on lithology. The research aims to predict the porosity to identify the reservoir which is in between the tight layer. So, the output of the seismic inversion is much more batter than the seismic as it is closer to reality such as geology. Seismic inversion is frequently used to determine rock physics properties, for example, acoustic impedance and porosity.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83010800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilse Lizeth Villegas-Velasquez, L. Pascual-Mathey, O. Valenzuela-Limón, Patricia Elisa Molina-Prior, Jose Locia-Espinoza, Ezri Cruz Perez, Magda Olivia Perez-Vasquez
Neonatal Sepsis (NS) is a systemic infection caused by bacteria, fungi, or viruses during the first month of life. Although various studies have identified the factors associated with NS, it is a public health problem due to its high morbidity and mortality. The study aimed to identify the risk factors associated with neonatal sepsis in the Neonatal Intensive Care Unit (NICU) of a tertiary hospital in Mexico. A case-control study was carried out using records of neonates (with sepsis 39 and without sepsis 39) from January to December 2017. The risk factors studied were the sociodemographic and clinical characteristics of the mother and clinics of the neonate. The data were analyzed using the Chi2 test, Fisher's exact test, Student's t-test, and the Odds Ratio (OR). The risk factors associated with NS were gestational age (OR 0.77, CI 95% = 0.64-0.91, p = 0.004), newborn weight (OR 0.45, CI95% = 0.23-0.86, p = 0.017) and days of hospital stay (OR 1.06, CI95% = 1.02-1.10, p = 0.0014). The mother's sociodemographic and clinical factors were not associated with NS. Risk factors associated with NS were gestational age, newborn weight, and days of hospital stay.
新生儿败血症(NS)是一种由细菌、真菌或病毒引起的全身性感染，发生在出生后的第一个月。虽然各种研究已经确定了与NS相关的因素，但由于其发病率和死亡率高，它是一个公共卫生问题。该研究旨在确定与墨西哥一家三级医院新生儿重症监护病房(NICU)新生儿败血症相关的危险因素。使用2017年1月至12月的新生儿(脓毒症39和非脓毒症39)记录进行病例对照研究。研究的危险因素是社会人口学和临床特征的母亲和诊所的新生儿。采用Chi2检验、Fisher精确检验、学生t检验和比值比(OR)对数据进行分析。与NS相关的危险因素为胎龄(OR 0.77, CI95% = 0.64-0.91, p = 0.004)、新生儿体重(OR 0.45, CI95% = 0.23-0.86, p = 0.017)和住院天数(OR 1.06, CI95% = 1.02-1.10, p = 0.0014)。母亲的社会人口学和临床因素与NS无关。与NS相关的危险因素有胎龄、新生儿体重和住院天数。
{"title":"Risk Factors for Sepsis in the Neonatal Intensive Care Unit of a Tertiary Hospital in Mexico","authors":"Ilse Lizeth Villegas-Velasquez, L. Pascual-Mathey, O. Valenzuela-Limón, Patricia Elisa Molina-Prior, Jose Locia-Espinoza, Ezri Cruz Perez, Magda Olivia Perez-Vasquez","doi":"10.37871/jbres1370","DOIUrl":"https://doi.org/10.37871/jbres1370","url":null,"abstract":"Neonatal Sepsis (NS) is a systemic infection caused by bacteria, fungi, or viruses during the first month of life. Although various studies have identified the factors associated with NS, it is a public health problem due to its high morbidity and mortality. The study aimed to identify the risk factors associated with neonatal sepsis in the Neonatal Intensive Care Unit (NICU) of a tertiary hospital in Mexico. A case-control study was carried out using records of neonates (with sepsis 39 and without sepsis 39) from January to December 2017. The risk factors studied were the sociodemographic and clinical characteristics of the mother and clinics of the neonate. The data were analyzed using the Chi2 test, Fisher's exact test, Student's t-test, and the Odds Ratio (OR). The risk factors associated with NS were gestational age (OR 0.77, CI 95% = 0.64-0.91, p = 0.004), newborn weight (OR 0.45, CI95% = 0.23-0.86, p = 0.017) and days of hospital stay (OR 1.06, CI95% = 1.02-1.10, p = 0.0014). The mother's sociodemographic and clinical factors were not associated with NS. Risk factors associated with NS were gestational age, newborn weight, and days of hospital stay.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89296896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an emerging virus responsible for the ongoing Coronavirus Disease 19 (COVID-19) pandemic. Despite the advent of COVID-19 vaccines, pandemic fatigue is still escalating as new SARS-CoV-2 variants emerge and vaccine shortages hit globally. Hence, drug repurposing remains an alternative strategy to combat SARS-CoV-2. For centuries, plants have served as natural reservoirs of pharmacologically active compounds with minimal cytotoxicity and promising antimicrobial and antiviral activities. In this light, the present study was undertaken to virtually screen 33 phytochemicals across various cultivars against the main protease (Mpro) and Spike (S) protein of SARS-CoV-2 using ADME analysis. 31 phytochemicals obeying Lipinski’s rules were subjected to molecular docking using AutoDock Vina. Docking scores were determined by selecting the best conformation of the protein-ligand complex that exhibited the highest affinity. The study identified withanone, licoflavone A, and silibinin to interact with the S protein at the hACE2-binding site with high binding energies. Similarly, myricitrin, withanone, naringenin, licoflavone A, and silibinin exhibited high binding affinities with the substrate-binding pocket of Mpro between the domains I and II. Interestingly, licoflavone A, silibinin, and withanone interacted with both Mpro and S proteins in silico. Further, drug-likeness studies indicated withanone to be the most readily bioavailable phytochemicals among the three shortlisted ligands. Therefore, phytochemicals can be regarded as potential leads for developing inhibitors against this mysterious virus. In vitro investigations are further warranted to prove their antiviral efficacy.
{"title":"Virtual Screening of Phytochemicals Targeting the Main Protease and Spike Protein of SARS-CoV-2: An In silico Approach","authors":"P. Gulati, Aarti Yadav, Jatin Chadha, S. Singh","doi":"10.37871/jbres1357","DOIUrl":"https://doi.org/10.37871/jbres1357","url":null,"abstract":"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an emerging virus responsible for the ongoing Coronavirus Disease 19 (COVID-19) pandemic. Despite the advent of COVID-19 vaccines, pandemic fatigue is still escalating as new SARS-CoV-2 variants emerge and vaccine shortages hit globally. Hence, drug repurposing remains an alternative strategy to combat SARS-CoV-2. For centuries, plants have served as natural reservoirs of pharmacologically active compounds with minimal cytotoxicity and promising antimicrobial and antiviral activities. In this light, the present study was undertaken to virtually screen 33 phytochemicals across various cultivars against the main protease (Mpro) and Spike (S) protein of SARS-CoV-2 using ADME analysis. 31 phytochemicals obeying Lipinski’s rules were subjected to molecular docking using AutoDock Vina. Docking scores were determined by selecting the best conformation of the protein-ligand complex that exhibited the highest affinity. The study identified withanone, licoflavone A, and silibinin to interact with the S protein at the hACE2-binding site with high binding energies. Similarly, myricitrin, withanone, naringenin, licoflavone A, and silibinin exhibited high binding affinities with the substrate-binding pocket of Mpro between the domains I and II. Interestingly, licoflavone A, silibinin, and withanone interacted with both Mpro and S proteins in silico. Further, drug-likeness studies indicated withanone to be the most readily bioavailable phytochemicals among the three shortlisted ligands. Therefore, phytochemicals can be regarded as potential leads for developing inhibitors against this mysterious virus. In vitro investigations are further warranted to prove their antiviral efficacy.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85143071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rajasthan, situated at the north-western part of India is the biggest state in the country of India and has total of 33 districts. By merging eight tribal dominating districts namely, Banswara, Chittourgarh, Dungarpur, Pali, Pratapgarh, Rajasamand, Sirohi, and Udaipur of these, the government has created a special area called the ‘schedule area” in which >70% of the people are tribal. This area is mostly backward and underdeveloped where malaria is also hyperendemic. In this area, Bhil, Damor, Meena, Garasiya, Kathudia and Sahariya are the most dominating and major endogamous tribes. Besides the several communicable and non-communicable diseases in this area, certain erythrocyte genetic disorders, Sickle-Cell Haemoglobin (Hb-S), β-thalassaemia and G-6-PD deficiency (Gd) are also deteriorating the tribal health and causing morbidity and mortality in them. Genes of these red cell genetic disorders are more prevalent and widely distributed among tribal people. The maximum prevalence of these blood genetic disorders in tribes was found as 31.14%, 9.00% and 22.00%, respectively. Since the groundwater of this tribal area contains a high amount of Fluoride (F), drinking it poses a high risk of premature death of tribal people who already have homozygous state of sickle-cell and β-thalassaemic genes. In present communication, besides the focus on tribal health, the status of genes of sickle-cell haemoglobin, β-thalassaemia and G-6-PD deficiency in different tribal ethnic groups of scheduled area, the correlation of these blood genetic disorders with malaria, impact of F intoxication in tribal subjects possessing red cell genetic disorders and the prevention and control of these erythrocyte genetic disorders in tribal people have been critically reviewed. The results of this review are significant and advantageous in making and execution of prevention and control programme of these blood genetic disorders in tribals of scheduled area of Rajasthan, India. Moreover, in this review, research gaps are also highlighted for further research work.
{"title":"A Brief Review of Sickle-Cell Haemoglobin, β-Thalassaemia and G-6-PD Deficiency Genes among Tribals of Scheduled Area of Rajasthan, India: Focus on Tribal Health","authors":"S. L. Choubisa, Anurag Choubisa","doi":"10.37871/jbres1371","DOIUrl":"https://doi.org/10.37871/jbres1371","url":null,"abstract":"Rajasthan, situated at the north-western part of India is the biggest state in the country of India and has total of 33 districts. By merging eight tribal dominating districts namely, Banswara, Chittourgarh, Dungarpur, Pali, Pratapgarh, Rajasamand, Sirohi, and Udaipur of these, the government has created a special area called the ‘schedule area” in which >70% of the people are tribal. This area is mostly backward and underdeveloped where malaria is also hyperendemic. In this area, Bhil, Damor, Meena, Garasiya, Kathudia and Sahariya are the most dominating and major endogamous tribes. Besides the several communicable and non-communicable diseases in this area, certain erythrocyte genetic disorders, Sickle-Cell Haemoglobin (Hb-S), β-thalassaemia and G-6-PD deficiency (Gd) are also deteriorating the tribal health and causing morbidity and mortality in them. Genes of these red cell genetic disorders are more prevalent and widely distributed among tribal people. The maximum prevalence of these blood genetic disorders in tribes was found as 31.14%, 9.00% and 22.00%, respectively. Since the groundwater of this tribal area contains a high amount of Fluoride (F), drinking it poses a high risk of premature death of tribal people who already have homozygous state of sickle-cell and β-thalassaemic genes. In present communication, besides the focus on tribal health, the status of genes of sickle-cell haemoglobin, β-thalassaemia and G-6-PD deficiency in different tribal ethnic groups of scheduled area, the correlation of these blood genetic disorders with malaria, impact of F intoxication in tribal subjects possessing red cell genetic disorders and the prevention and control of these erythrocyte genetic disorders in tribal people have been critically reviewed. The results of this review are significant and advantageous in making and execution of prevention and control programme of these blood genetic disorders in tribals of scheduled area of Rajasthan, India. Moreover, in this review, research gaps are also highlighted for further research work.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82563409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Parveen, Hanfa Ashfaq, M. Shahid, Ambreen Kanwal, A. Tayyeb
Within a tumor, Cancer Stem Cells (CSCs) exists and own similar characteristics of a normal stem cell thus contributing towards aggressiveness of cancer by playing crucial role in tumor recurrence and metastasis capability. Various studies have been conducted to therapeutically target CSCs. One of the approaches include is to inhibit cell cycle progression in CSCs. Within last two decades cell cycle and role of various components in its regulation is firmly established. Cell cycle is regulated by Cyclin Dependent Kinases (CDK) bound to cyclin. CDK activity can be blocked by Cyclin-Dependent Kinase Inhibitors (CKIs) which can either bind cyclin/CDK complex or CDK alone and thus stops cell cycle. In this review various studies are discussed that have investigated the therapeutic role of CKIs in eradicating CSCs by inhibiting cell cycle. Overall, the analysis suggests that CKIs could be a potential therapeutic option in controlling CSCs populating in a tumor.
{"title":"Emerging Therapeutic Role of CDK Inhibitors in Targeting Cancer Stem Cells","authors":"S. Parveen, Hanfa Ashfaq, M. Shahid, Ambreen Kanwal, A. Tayyeb","doi":"10.37871/jbres1355","DOIUrl":"https://doi.org/10.37871/jbres1355","url":null,"abstract":"Within a tumor, Cancer Stem Cells (CSCs) exists and own similar characteristics of a normal stem cell thus contributing towards aggressiveness of cancer by playing crucial role in tumor recurrence and metastasis capability. Various studies have been conducted to therapeutically target CSCs. One of the approaches include is to inhibit cell cycle progression in CSCs. Within last two decades cell cycle and role of various components in its regulation is firmly established. Cell cycle is regulated by Cyclin Dependent Kinases (CDK) bound to cyclin. CDK activity can be blocked by Cyclin-Dependent Kinase Inhibitors (CKIs) which can either bind cyclin/CDK complex or CDK alone and thus stops cell cycle. In this review various studies are discussed that have investigated the therapeutic role of CKIs in eradicating CSCs by inhibiting cell cycle. Overall, the analysis suggests that CKIs could be a potential therapeutic option in controlling CSCs populating in a tumor.","PeriodicalId":94067,"journal":{"name":"Journal of biomedical research & environmental sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89696280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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